HELRO|EnsemblGenome=HelroG78854|UniProtKB=T1G3G3 T1G3G3 20215611 PTHR23092:SF15 POLY(A) RNA POLYMERASE INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED adenylyltransferase activity#GO:0070566;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;transferase activity#GO:0016740;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772;mRNA binding#GO:0003729 cellular aromatic compound metabolic process#GO:0006725;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;modification-dependent macromolecule catabolic process#GO:0043632;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;organic substance catabolic process#GO:1901575;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;macromolecule biosynthetic process#GO:0009059;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;polyadenylation-dependent ncRNA catabolic process#GO:0043634 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG107948|UniProtKB=T1EEE3 T1EEE3 20194945 PTHR45625:SF4 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1 peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein peptidyl-prolyl isomerization#GO:0000413;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 chaperone#PC00072 HELRO|EnsemblGenome=HelroG172327|UniProtKB=T1F574 T1F574 20203973 PTHR23359:SF70 NUCLEOTIDE KINASE ADENYLATE KINASE 1, ISOFORM B transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, phosphate group as acceptor#GO:0016776;catalytic activity#GO:0003824;kinase activity#GO:0016301 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 nucleotide kinase#PC00172;kinase#PC00137 De novo purine biosynthesis#P02738>Adenylate kinase#P02896 HELRO|EnsemblGenome=HelroG109107|UniProtKB=T1EEQ4 T1EEQ4 20195056 PTHR46237:SF1 CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER CYTOCHROME B5 REDUCTASE 4 binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor#GO:0016653;tetrapyrrole binding#GO:0046906;oxidoreductase activity, acting on NAD(P)H#GO:0016651;oxidoreductase activity#GO:0016491;heme binding#GO:0020037 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 reductase#PC00198;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG189200|UniProtKB=T1FQS1 T1FQS1 20211168 PTHR10082:SF60 INTEGRIN BETA SUBUNIT INTEGRIN BETA-PS cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;integrin binding#GO:0005178;binding#GO:0005488;signaling receptor binding#GO:0005102 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;cell adhesion mediated by integrin#GO:0033627;cell-cell adhesion#GO:0098609;cell motility#GO:0048870;cell adhesion#GO:0007155;cell communication#GO:0007154;cell-substrate adhesion#GO:0031589;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cell-matrix adhesion#GO:0007160;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;integrin-mediated signaling pathway#GO:0007229;cell migration#GO:0016477;signaling#GO:0023052 receptor complex#GO:0043235;membrane protein complex#GO:0098796;cell surface#GO:0009986;protein-containing complex#GO:0032991;plasma membrane signaling receptor complex#GO:0098802;anchoring junction#GO:0070161;plasma membrane protein complex#GO:0098797;focal adhesion#GO:0005925;cell junction#GO:0030054;cell-substrate junction#GO:0030055;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;integrin#PC00126 Integrin signalling pathway#P00034>Integrin beta#P00931 HELRO|EnsemblGenome=HelroG108094|UniProtKB=T1EEF3 T1EEF3 20194955 PTHR11699:SF190 ALDEHYDE DEHYDROGENASE-RELATED 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 dehydrogenase#PC00092;oxidoreductase#PC00176 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HELRO|EnsemblGenome=HelroG160072|UniProtKB=T1EPQ9 T1EPQ9 20198559 PTHR11913:SF12 COFILIN-RELATED COFILIN_ACTIN-DEPOLYMERIZING FACTOR HOMOLOG-RELATED cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;cellular component disassembly#GO:0022411;actin filament-based process#GO:0030029;protein-containing complex disassembly#GO:0032984;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;actin polymerization or depolymerization#GO:0008154;cellular component organization#GO:0016043;protein depolymerization#GO:0051261;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;actin filament depolymerization#GO:0030042 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 Cytoskeletal regulation by Rho GTPase#P00016>Cofilin#P00508 HELRO|EnsemblGenome=HelroG110871|UniProtKB=T1EF59 T1EF59 20195211 PTHR24390:SF244 ZINC FINGER PROTEIN LD33778P-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG182128|UniProtKB=T1FHT1 T1FHT1 20208380 PTHR33332:SF48 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183406|UniProtKB=T1FJK9 T1FJK9 20209008 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG177237|UniProtKB=T1FBE1 T1FBE1 20206140 PTHR46273:SF4 MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED AT19640P signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG65942|UniProtKB=T1FYE7 T1FYE7 20213845 PTHR11849:SF302 ETS ETS DOMAIN-CONTAINING PROTEIN-RELATED transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG160206|UniProtKB=T1EPZ1 T1EPZ1 20198641 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG95192|UniProtKB=T1G949 T1G949 20217596 PTHR16515:SF66 PR DOMAIN ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG92232|UniProtKB=T1G8D3 T1G8D3 20217330 PTHR44666:SF1 WD REPEAT-CONTAINING PROTEIN 53 WD REPEAT-CONTAINING PROTEIN 53 HELRO|EnsemblGenome=HelroG175001|UniProtKB=T1F8Q0 T1F8Q0 20205199 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG189560|UniProtKB=T1FR56 T1FR56 20211303 PTHR47705:SF1 AGAP000321-PA PNP_UDP_1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171303|UniProtKB=T1F424 T1F424 20203573 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177642|UniProtKB=T1FBZ8 T1FBZ8 20206347 PTHR45798:SF97 RING-H2 FINGER PROTEIN ATL61-RELATED-RELATED ALCOHOL-SENSITIVE RING FINGER PROTEIN 1 HELRO|EnsemblGenome=HelroG179272|UniProtKB=T1FEG6 T1FEG6 20207215 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG167827|UniProtKB=T1EZU6 T1EZU6 20202096 PTHR43591:SF24 METHYLTRANSFERASE 2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL methyltransferase activity#GO:0008168;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824 methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG190258|UniProtKB=T1FRT7 T1FRT7 20211534 PTHR13091:SF0 AMPLIFIED IN BREAST CANCER 2-RELATED NONSENSE-MEDIATED MRNA DECAY FACTOR SMG8 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;mRNA catabolic process#GO:0006402;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;organic substance catabolic process#GO:1901575;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;nuclear-transcribed mRNA catabolic process#GO:0000956;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 HELRO|EnsemblGenome=HelroG114692|UniProtKB=T1EG41 T1EG41 20195543 PTHR23273:SF172 REPLICATION FACTOR A 1, RFA1 REPLICATION PROTEIN A 70 KDA DNA-BINDING SUBUNIT sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;single-stranded telomeric DNA binding#GO:0043047;single-stranded DNA binding#GO:0003697;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;damaged DNA binding#GO:0003684;telomeric DNA binding#GO:0042162 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;telomere maintenance via telomere lengthening#GO:0010833;double-strand break repair#GO:0006302;telomere organization#GO:0032200;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;telomere maintenance#GO:0000723;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;recombinational repair#GO:0000725;reproductive process#GO:0022414;telomere maintenance via telomerase#GO:0007004;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;nucleotide-excision repair#GO:0006289;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;meiotic cell cycle#GO:0051321;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;organic cyclic compound biosynthetic process#GO:1901362;double-strand break repair via homologous recombination#GO:0000724;cellular process#GO:0009987;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;response to stress#GO:0006950;reproduction#GO:0000003;organelle organization#GO:0006996;chromosome organization#GO:0051276;DNA biosynthetic process#GO:0071897;sexual reproduction#GO:0019953;cell cycle#GO:0007049;aromatic compound biosynthetic process#GO:0019438;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;replisome#GO:0030894;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nuclear replication fork#GO:0043596;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513;replication fork#GO:0005657 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG119463|UniProtKB=T1EGN2 T1EGN2 20195732 PTHR24238:SF57 G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTOR 83 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;neuropeptide signaling pathway#GO:0007218;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG85149|UniProtKB=T1G5T4 T1G5T4 20216431 PTHR12644:SF0 ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 5 cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;Arp2/3 complex-mediated actin nucleation#GO:0034314;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;Arp2/3 protein complex#GO:0005885;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Integrin signalling pathway#P00034>Arp2/3#P00912;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Arp2/3#P00876;Cytoskeletal regulation by Rho GTPase#P00016>ARP2/3#P00511 HELRO|EnsemblGenome=HelroG172690|UniProtKB=T1F5S7 T1F5S7 20204176 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192798|UniProtKB=T1FUB1 T1FUB1 20212407 PTHR19375:SF395 HEAT SHOCK PROTEIN 70KDA HEAT SHOCK 70 KDA PROTEIN ISOFORM X1-RELATED cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 Hsp70 family chaperone#PC00027 Parkinson disease#P00049>Hsp70#P01208;Apoptosis signaling pathway#P00006>HSP70#P00321 HELRO|EnsemblGenome=HelroG70875|UniProtKB=T1G0D3 T1G0D3 20214531 PTHR10484:SF207 HISTONE H4 HISTONE H4 nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;nucleosome organization#GO:0034728;nucleosome assembly#GO:0006334;protein-containing complex organization#GO:0043933;protein-containing complex assembly#GO:0065003;chromatin organization#GO:0006325;cellular component organization#GO:0016043;cellular process#GO:0009987;chromatin remodeling#GO:0006338;protein-DNA complex assembly#GO:0065004 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG165578|UniProtKB=T1EX11 T1EX11 20201111 PTHR10917:SF0 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3 catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;RNA polymerase activity#GO:0097747;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;RNA polymerase III activity#GO:0001056;RNA polymerase II activity#GO:0001055;RNA polymerase I activity#GO:0001054 membrane-enclosed lumen#GO:0031974;RNA polymerase II, core complex#GO:0005665;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase II, holoenzyme#GO:0016591;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;RNA polymerase III complex#GO:0005666;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;RNA polymerase I complex#GO:0005736;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388;General transcription regulation#P00023>RNA Polymerase II#P00660 HELRO|EnsemblGenome=HelroG79322|UniProtKB=T1G3M7 T1G3M7 20215675 PTHR14167:SF76 SH3 DOMAIN-CONTAINING ENDOPHILIN B, ISOFORM A cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cellular process#GO:0009987;membrane organization#GO:0061024 cellular anatomical entity#GO:0110165;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG193731|UniProtKB=T1FVA9 T1FVA9 20212755 PTHR13471:SF0 TETRATRICOPEPTIDE-LIKE HELICAL NUCLEAR EXOSOME REGULATOR NRDE2 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;protein-DNA complex organization#GO:0071824;negative regulation of biological process#GO:0048519;regulation of catabolic process#GO:0009894;negative regulation of RNA metabolic process#GO:0051253;regulation of nitrogen compound metabolic process#GO:0051171;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular catabolic process#GO:0031330;cellular component organization#GO:0016043;negative regulation of metabolic process#GO:0009892;regulation of cellular catabolic process#GO:0031329;negative regulation of gene expression, epigenetic#GO:0045814;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;epigenetic regulation of gene expression#GO:0040029;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of catabolic process#GO:0009895;regulation of cellular biosynthetic process#GO:0031326;heterochromatin organization#GO:0070828;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;protein-containing complex organization#GO:0043933;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;chromatin organization#GO:0006325;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;chromatin remodeling#GO:0006338;negative regulation of RNA catabolic process#GO:1902369;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 ribonucleoprotein complex#GO:1990904;catalytic step 2 spliceosome#GO:0071013;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG76714|UniProtKB=T1G2N2 T1G2N2 20215330 PTHR12772:SF0 DNA REPLICATION COMPLEX GINS PROTEIN PSF2 DNA REPLICATION COMPLEX GINS PROTEIN PSF2 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;double-strand break repair via homologous recombination#GO:0000724;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;response to stress#GO:0006950;double-strand break repair via break-induced replication#GO:0000727;nitrogen compound metabolic process#GO:0006807;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;DNA replication preinitiation complex#GO:0031261;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;GINS complex#GO:0000811;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG166741|UniProtKB=T1EYG6 T1EYG6 20201616 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180571|UniProtKB=T1FG21 T1FG21 20207770 PTHR31516:SF17 STABILIZER OF AXONEMAL MICROTUBULES 2 STABILIZER OF AXONEMAL MICROTUBULES 2 cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;microtubule binding#GO:0008017;tubulin binding#GO:0015631;binding#GO:0005488 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG99199|UniProtKB=T1G9R4 T1G9R4 20217810 PTHR48030:SF3 SPLICING FACTOR 3B SUBUNIT 4 SPLICING FACTOR 3B SUBUNIT 4 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 positive regulation of gene expression#GO:0010628;positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of mRNA metabolic process#GO:1903313;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of mRNA processing#GO:0050684;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;regulation of mRNA splicing, via spliceosome#GO:0048024;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;precatalytic spliceosome#GO:0071011;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG185387|UniProtKB=T1FMR2 T1FMR2 20210111 PTHR15497:SF1 3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE 3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG130721|UniProtKB=T1EHU5 T1EHU5 20196145 PTHR45646:SF2 SERINE/THREONINE-PROTEIN KINASE DOA-RELATED PROTEIN KINASE DOMAIN-CONTAINING PROTEIN non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG123209|UniProtKB=T1EGX3 T1EGX3 20195823 PTHR11003:SF348 POTASSIUM CHANNEL, SUBFAMILY K POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG180324|UniProtKB=T1FFR0 T1FFR0 20207659 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192435|UniProtKB=T1FTY6 T1FTY6 20212283 PTHR12618:SF20 PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1 PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG177823|UniProtKB=T1FCB8 T1FCB8 20206467 PTHR46927:SF3 AGAP005574-PA THAP-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG115758|UniProtKB=T1EGA2 T1EGA2 20195604 PTHR11226:SF0 UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE UDP-glucosyltransferase activity#GO:0035251;transferase activity#GO:0016740;unfolded protein binding#GO:0051082;glycosyltransferase activity#GO:0016757;binding#GO:0005488;catalytic activity#GO:0003824;UDP-glycosyltransferase activity#GO:0008194;protein binding#GO:0005515;glucosyltransferase activity#GO:0046527;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule modification#GO:0043412;protein catabolic process#GO:0030163;organonitrogen compound catabolic process#GO:1901565;protein modification process#GO:0036211;biosynthetic process#GO:0009058;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein N-linked glycosylation via asparagine#GO:0018279;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;response to organic substance#GO:0010033;macromolecule catabolic process#GO:0009057;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein glycosylation#GO:0006486;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;ERAD pathway#GO:0036503;response to organonitrogen compound#GO:0010243;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;protein N-linked glycosylation#GO:0006487;cellular response to stress#GO:0033554;glycosylation#GO:0070085 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG170307|UniProtKB=T1F2W7 T1F2W7 20203166 PTHR42884:SF3 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED FURIN-LIKE PROTEASE 1, ISOFORMS 1_1-X_2 hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 bounding membrane of organelle#GO:0098588;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791;Golgi membrane#GO:0000139 serine protease#PC00203;protein modifying enzyme#PC00260 Activin beta signaling pathway#P06210>FUR1#P06238;Endothelin signaling pathway#P00019>furin#P00575;GBB signaling pathway#P06214>FUR1#P06298;SCW signaling pathway#P06216>FUR1#P06333;DPP-SCW signaling pathway#P06212>FUR1#P06263;DPP signaling pathway#P06213>FUR1#P06290;ALP23B signaling pathway#P06209>FUR1#P06227;Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105;BMP/activin signaling pathway-drosophila#P06211>Furin#P06244;Alzheimer disease-presenilin pathway#P00004>Furin#P00157;MYO signaling pathway#P06215>FUR1#P06318 HELRO|EnsemblGenome=HelroG190617|UniProtKB=T1FS52 T1FS52 20211649 PTHR24161:SF124 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED TRANSIENT RECEPTOR POTENTIAL CHANNEL PYREXIA protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG189697|UniProtKB=T1FR97 T1FR97 20211344 PTHR46641:SF25 FMRFAMIDE RECEPTOR-RELATED CNMAMIDE RECEPTOR-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG174805|UniProtKB=T1F8I0 T1F8I0 20205129 PTHR12479:SF10 LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN bounding membrane of organelle#GO:0098588;lytic vacuole membrane#GO:0098852;intracellular membrane-bounded organelle#GO:0043231;vacuolar membrane#GO:0005774;vacuole#GO:0005773;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;lytic vacuole#GO:0000323;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;lysosomal membrane#GO:0005765;lysosome#GO:0005764;membrane-bounded organelle#GO:0043227 transporter#PC00227 HELRO|EnsemblGenome=HelroG162998|UniProtKB=T1ETJ0 T1ETJ0 20199890 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG115201|UniProtKB=T1EG72 T1EG72 20195574 PTHR18034:SF3 CELL CYCLE CONTROL PROTEIN CWF22-RELATED PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;catalytic step 2 spliceosome#GO:0071013;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG189761|UniProtKB=T1FRC6 T1FRC6 20211373 PTHR11670:SF54 ACONITASE/IRON-RESPONSIVE ELEMENT FAMILY MEMBER IRON REGULATORY PROTEIN 1A-RELATED carbon-oxygen lyase activity#GO:0016835;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;small molecule binding#GO:0036094;binding#GO:0005488;iron-sulfur cluster binding#GO:0051536;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;hydro-lyase activity#GO:0016836;lyase activity#GO:0016829;mRNA binding#GO:0003729 oxoacid metabolic process#GO:0043436;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;carboxylic acid metabolic process#GO:0019752;energy derivation by oxidation of organic compounds#GO:0015980;tricarboxylic acid cycle#GO:0006099;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 Methylcitrate cycle#P02754>Aconitase#P03028 HELRO|EnsemblGenome=HelroG167002|UniProtKB=T1EYV6 T1EYV6 20201756 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG66811|UniProtKB=T1FYR2 T1FYR2 20213960 PTHR12895:SF9 DYMECLIN DYMECLIN endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cellular process#GO:0009987;Golgi organization#GO:0007030;organelle organization#GO:0006996 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG179070|UniProtKB=T1FE51 T1FE51 20207100 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG172110|UniProtKB=T1F515 T1F515 20203914 PTHR48209:SF2 AGL056WP FI24008P1 HELRO|EnsemblGenome=HelroG192587|UniProtKB=T1FU38 T1FU38 20212334 PTHR16083:SF85 LEUCINE RICH REPEAT CONTAINING PROTEIN FI16115P1 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG159330|UniProtKB=T1ENW1 T1ENW1 20198261 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG156800|UniProtKB=T1EM13 T1EM13 20197613 PTHR13110:SF0 U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3 LSM3 HOMOLOG, U6 SMALL NUCLEAR RNA AND MRNA DEGRADATION ASSOCIATED RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;organic cyclic compound metabolic process#GO:1901360;mRNA metabolic process#GO:0016071;nitrogen compound metabolic process#GO:0006807;P-body assembly#GO:0033962;non-membrane-bounded organelle assembly#GO:0140694;mRNA splicing, via spliceosome#GO:0000398;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular component assembly#GO:0022607;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;organelle organization#GO:0006996;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375 supramolecular complex#GO:0099080;catalytic step 2 spliceosome#GO:0071013;U6 snRNP#GO:0005688;nucleus#GO:0005634;P-body#GO:0000932;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;U4/U6 x U5 tri-snRNP complex#GO:0046540;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein complex#GO:1990904;ribonucleoprotein granule#GO:0035770;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;spliceosomal tri-snRNP complex#GO:0097526;membrane-bounded organelle#GO:0043227;precatalytic spliceosome#GO:0071011;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG181053|UniProtKB=T1FGK2 T1FGK2 20207951 PTHR14098:SF14 SH2 DOMAIN CONTAINING PROTEIN SH2 DOMAIN-CONTAINING PROTEIN regulation of biological process#GO:0050789;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG156254|UniProtKB=T1ELT5 T1ELT5 20197535 PTHR10663:SF402 GUANYL-NUCLEOTIDE EXCHANGE FACTOR MIP16918P guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG190292|UniProtKB=T1FRV3 T1FRV3 20211550 PTHR22770:SF47 UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED E3 UBIQUITIN-PROTEIN LIGASE RNF216 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG94333|UniProtKB=T1G902 T1G902 20217549 PTHR11406:SF0 PHOSPHOGLYCERATE KINASE PHOSPHOGLYCERATE KINASE carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;transferase activity#GO:0016740;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;transferase activity, transferring phosphorus-containing groups#GO:0016772;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168;kinase activity#GO:0016301;ATP binding#GO:0005524 ribonucleoside triphosphate metabolic process#GO:0009199;nucleoside triphosphate metabolic process#GO:0009141;heterocycle catabolic process#GO:0046700;ribonucleotide catabolic process#GO:0009261;pyridine nucleotide metabolic process#GO:0019362;nucleobase-containing compound metabolic process#GO:0006139;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;purine ribonucleotide catabolic process#GO:0009154;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;oxoacid metabolic process#GO:0043436;nucleoside phosphate catabolic process#GO:1901292;carbohydrate derivative catabolic process#GO:1901136;purine ribonucleoside triphosphate metabolic process#GO:0009205;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;nucleotide catabolic process#GO:0009166;cellular nitrogen compound metabolic process#GO:0034641;nicotinamide nucleotide metabolic process#GO:0046496;nucleoside diphosphate catabolic process#GO:0009134;organic acid metabolic process#GO:0006082;ribonucleotide metabolic process#GO:0009259;monocarboxylic acid metabolic process#GO:0032787;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;organophosphate catabolic process#GO:0046434;hexose biosynthetic process#GO:0019319;glycolytic process#GO:0006096;organophosphate metabolic process#GO:0019637;small molecule biosynthetic process#GO:0044283;nucleobase-containing compound catabolic process#GO:0034655;nucleotide metabolic process#GO:0009117;small molecule metabolic process#GO:0044281;cellular aromatic compound metabolic process#GO:0006725;monosaccharide metabolic process#GO:0005996;carbohydrate derivative metabolic process#GO:1901135;organonitrogen compound catabolic process#GO:1901565;biosynthetic process#GO:0009058;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;purine-containing compound catabolic process#GO:0072523;cellular nitrogen compound catabolic process#GO:0044270;purine nucleotide catabolic process#GO:0006195;organic cyclic compound metabolic process#GO:1901360;carbohydrate catabolic process#GO:0016052;catabolic process#GO:0009056;nucleoside diphosphate metabolic process#GO:0009132;organic substance catabolic process#GO:1901575;carbohydrate metabolic process#GO:0005975;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;carbohydrate biosynthetic process#GO:0016051;heterocycle metabolic process#GO:0046483;organonitrogen compound metabolic process#GO:1901564;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;glucose metabolic process#GO:0006006;aromatic compound catabolic process#GO:0019439;organic cyclic compound catabolic process#GO:1901361;purine nucleoside triphosphate metabolic process#GO:0009144;hexose metabolic process#GO:0019318;carboxylic acid metabolic process#GO:0019752;nucleobase-containing small molecule metabolic process#GO:0055086 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 carbohydrate kinase#PC00065 Glycolysis#P00024>Phosphoglycerate kinase#P00671 HELRO|EnsemblGenome=HelroG115827|UniProtKB=T1EGB0 T1EGB0 20195612 PTHR11462:SF35 JUN TRANSCRIPTION FACTOR-RELATED TRANSCRIPTION FACTOR JRA sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667 DNA-binding transcription factor#PC00218;basic leucine zipper transcription factor#PC00056 TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>AP-1#P00838 HELRO|EnsemblGenome=HelroG187003|UniProtKB=T1FP54 T1FP54 20210601 PTHR10257:SF5 SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B WIDERBORST, ISOFORM H phosphatase regulator activity#GO:0019208;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888 macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;dephosphorylation#GO:0016311;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;protein metabolic process#GO:0019538;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 Wnt signaling pathway#P00057>PP2A#P01438;FGF signaling pathway#P00021>PP2A#P00629;EGF receptor signaling pathway#P00018>PP2A#P00547 HELRO|EnsemblGenome=HelroG194142|UniProtKB=T1FVR3 T1FVR3 20212909 PTHR23326:SF1 CCR4 NOT-RELATED CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 3 negative regulation of gene expression#GO:0010629;regulation of catabolic process#GO:0009894;heterocycle catabolic process#GO:0046700;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;nucleobase-containing compound metabolic process#GO:0006139;RNA destabilization#GO:0050779;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;regulation of biological quality#GO:0065008;nitrogen compound metabolic process#GO:0006807;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;positive regulation of mRNA catabolic process#GO:0061014;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of catabolic process#GO:0009896;mRNA destabilization#GO:0061157;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323;positive regulation of nitrogen compound metabolic process#GO:0051173;cellular aromatic compound metabolic process#GO:0006725;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;RNA metabolic process#GO:0016070;positive regulation of cellular catabolic process#GO:0031331;cellular nitrogen compound catabolic process#GO:0044270;organic cyclic compound metabolic process#GO:1901360;positive regulation of metabolic process#GO:0009893;mRNA catabolic process#GO:0006402;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;positive regulation of mRNA metabolic process#GO:1903313;heterocycle metabolic process#GO:0046483;negative regulation of biosynthetic process#GO:0009890;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of cellular catabolic process#GO:0031329;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;positive regulation of RNA metabolic process#GO:0051254 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;protein-containing complex#GO:0032991;P-body#GO:0000932;CCR4-NOT complex#GO:0030014;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular anatomical structure#GO:0005622 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG157641|UniProtKB=T1EME3 T1EME3 20197743 PTHR24379:SF121 KRAB AND ZINC FINGER DOMAIN-CONTAINING C2H2-TYPE DOMAIN-CONTAINING PROTEIN C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG184743|UniProtKB=T1FLW9 T1FLW9 20209818 PTHR24228:SF74 B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG110482|UniProtKB=T1EF27 T1EF27 20195179 PTHR24223:SF447 ATP-BINDING CASSETTE SUB-FAMILY C MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 5 transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG186621|UniProtKB=T1FP18 T1FP18 20210565 PTHR43389:SF4 V-TYPE PROTON ATPASE SUBUNIT B V-TYPE PROTON ATPASE SUBUNIT B ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG185060|UniProtKB=T1FMC2 T1FMC2 20209971 PTHR12832:SF11 TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11 LD23868P regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG183720|UniProtKB=T1FK38 T1FK38 20209187 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188705|UniProtKB=T1FQA0 T1FQA0 20210997 PTHR14234:SF19 RIM BINDING PROTEIN-RELATED RIM-BINDING PROTEIN, ISOFORM F regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;anterograde trans-synaptic signaling#GO:0098916;biological regulation#GO:0065007;synaptic signaling#GO:0099536;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;neuromuscular synaptic transmission#GO:0007274;cellular process#GO:0009987;signaling#GO:0023052;cell-cell signaling#GO:0007267 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG160884|UniProtKB=T1F2I8 T1F2I8 20203038 PTHR46601:SF1 ULP_PROTEASE DOMAIN-CONTAINING PROTEIN ADF-H DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG115063|UniProtKB=T1EG61 T1EG61 20195563 PTHR48067:SF1 GPI-ANCHOR TRANSAMIDASE GPI-ANCHOR TRANSAMIDASE hydrolase activity#GO:0016787;cysteine-type peptidase activity#GO:0008234;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197 lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;phospholipid biosynthetic process#GO:0008654;macromolecule modification#GO:0043412;phosphatidylinositol biosynthetic process#GO:0006661;organophosphate biosynthetic process#GO:0090407;glycolipid metabolic process#GO:0006664;protein modification process#GO:0036211;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;glycerolipid biosynthetic process#GO:0045017;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;organic substance biosynthetic process#GO:1901576;liposaccharide metabolic process#GO:1903509;cellular process#GO:0009987;membrane lipid biosynthetic process#GO:0046467;GPI anchor metabolic process#GO:0006505;lipoprotein biosynthetic process#GO:0042158;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;GPI anchor biosynthetic process#GO:0006506;membrane lipid metabolic process#GO:0006643;glycerophospholipid biosynthetic process#GO:0046474;glycolipid biosynthetic process#GO:0009247;organophosphate metabolic process#GO:0019637;lipoprotein metabolic process#GO:0042157;cellular lipid metabolic process#GO:0044255 membrane protein complex#GO:0098796;peptidase complex#GO:1905368;endoplasmic reticulum protein-containing complex#GO:0140534;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endopeptidase complex#GO:1905369;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG111197|UniProtKB=T1EF95 T1EF95 20195247 PTHR44156:SF5 SUPERNUMERARY LIMBS, ISOFORM B-RELATED WD REPEAT-CONTAINING PROTEIN 55 HELRO|EnsemblGenome=HelroG83339|UniProtKB=T1G544 T1G544 20216192 PTHR12013:SF0 SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN localization#GO:0051179;cellular localization#GO:0051641;protein localization to endoplasmic reticulum#GO:0070972;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;protein targeting#GO:0006605;establishment of protein localization to organelle#GO:0072594;protein targeting to ER#GO:0045047;protein localization to organelle#GO:0033365;cellular process#GO:0009987;establishment of protein localization to endoplasmic reticulum#GO:0072599;establishment of protein localization#GO:0045184;protein localization#GO:0008104 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG99776|UniProtKB=T1G9V2 T1G9V2 20217848 PTHR10502:SF239 ANNEXIN ANNEXIN A7 lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488;phosphatidylserine binding#GO:0001786 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;vesicle membrane#GO:0012506;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG161577|UniProtKB=T1ERN0 T1ERN0 20199230 PTHR10199:SF119 THROMBOSPONDIN RE20510P external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;cellular anatomical entity#GO:0110165 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG171705|UniProtKB=T1F4K6 T1F4K6 20203755 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED FMRFAMIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG191861|UniProtKB=T1FTD2 T1FTD2 20212079 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG174268|UniProtKB=T1F7W9 T1F7W9 20204918 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN SI:DKEY-17M8.2 HELRO|EnsemblGenome=HelroG190058|UniProtKB=T1FRM8 T1FRM8 20211475 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG191484|UniProtKB=T1FT10 T1FT10 20211957 PTHR15126:SF4 SH3-BINDING SH3 DOMAIN-BINDING PROTEIN 2 HELRO|EnsemblGenome=HelroG113590|UniProtKB=T1EFU1 T1EFU1 20195443 PTHR10762:SF1 DIPHTHAMIDE BIOSYNTHESIS PROTEIN 2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;primary metabolic process#GO:0044238 HELRO|EnsemblGenome=HelroG159553|UniProtKB=T1EP56 T1EP56 20198356 PTHR22655:SF2 ATP-DEPENDENT RNA HELICASE TDRD12-RELATED ATP-DEPENDENT RNA HELICASE TDRD12-RELATED germ cell development#GO:0007281;cellular developmental process#GO:0048869;cell division#GO:0051301;gamete generation#GO:0007276;cellular process involved in reproduction in multicellular organism#GO:0022412;multicellular organism reproduction#GO:0032504;developmental process#GO:0032502;cellular process#GO:0009987;developmental process involved in reproduction#GO:0003006;cell development#GO:0048468;cell differentiation#GO:0030154;reproduction#GO:0000003;anatomical structure development#GO:0048856;sexual reproduction#GO:0019953;reproductive process#GO:0022414;multicellular organismal process#GO:0032501;multicellular organismal reproductive process#GO:0048609 HELRO|EnsemblGenome=HelroG124289|UniProtKB=T1EH07 T1EH07 20195857 PTHR24390:SF237 ZINC FINGER PROTEIN FI23536P1-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG186126|UniProtKB=T1FNP6 T1FNP6 20210443 PTHR13718:SF4 RIBOSOMAL S SUBUNIT 40S RIBOSOMAL PROTEIN S2 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;cytosol#GO:0005829;small ribosomal subunit#GO:0015935;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG91316|UniProtKB=T1G825 T1G825 20217222 PTHR10857:SF106 COPINE C2 DOMAIN-CONTAINING PROTEIN lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;cellular process#GO:0009987;response to chemical#GO:0042221 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG67787|UniProtKB=T1FZ53 T1FZ53 20214101 PTHR13342:SF2 RAGULATOR COMPLEX PROTEIN LAMTOR5 RAGULATOR COMPLEX PROTEIN LAMTOR5 nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 positive regulation of signal transduction#GO:0009967;regulation of signaling#GO:0023051;cellular response to nitrogen compound#GO:1901699;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;positive regulation of response to stimulus#GO:0048584;cellular response to oxygen-containing compound#GO:1901701;response to endogenous stimulus#GO:0009719;positive regulation of TOR signaling#GO:0032008;regulation of signal transduction#GO:0009966;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;response to organic substance#GO:0010033;regulation of cell communication#GO:0010646;positive regulation of TORC1 signaling#GO:1904263;cellular response to stimulus#GO:0051716;regulation of TORC1 signaling#GO:1903432;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;cellular response to organic substance#GO:0071310;response to organonitrogen compound#GO:0010243;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;cellular response to organonitrogen compound#GO:0071417;positive regulation of cell communication#GO:0010647;biological regulation#GO:0065007 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;vacuolar membrane#GO:0005774;vacuole#GO:0005773;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;lytic vacuole#GO:0000323;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;lysosome#GO:0005764;membrane-bounded organelle#GO:0043227;guanyl-nucleotide exchange factor complex#GO:0032045 HELRO|EnsemblGenome=HelroG112347|UniProtKB=T1EFJ0 T1EFJ0 20195342 PTHR10288:SF339 KH DOMAIN CONTAINING RNA BINDING PROTEIN RNA-BINDING PROTEIN PASILLA nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG193504|UniProtKB=T1FV24 T1FV24 20212670 PTHR12984:SF15 SCY1-RELATED S/T PROTEIN KINASE-LIKE PROTEIN-ASSOCIATING WITH THE CARBOXYL-TERMINAL DOMAIN OF EZRIN non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG172640|UniProtKB=T1F5P5 T1F5P5 20204144 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176320|UniProtKB=T1FAE0 T1FAE0 20205789 PTHR24238:SF75 G-PROTEIN COUPLED RECEPTOR CHOLECYSTOKININ-LIKE RECEPTOR AT 17D1-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;neuropeptide signaling pathway#GO:0007218;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG180151|UniProtKB=T1FFJ0 T1FFJ0 20207589 PTHR16056:SF2 REGULATOR OF MICROTUBULE DYNAMICS PROTEIN TESTIS-EXPRESSED PROTEIN 10 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG189703|UniProtKB=T1FRA1 T1FRA1 20211348 PTHR46641:SF25 FMRFAMIDE RECEPTOR-RELATED CNMAMIDE RECEPTOR-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG159677|UniProtKB=T1EPA8 T1EPA8 20198408 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166552|UniProtKB=T1EY86 T1EY86 20201536 PTHR11106:SF111 GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED MACRO DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG109569|UniProtKB=T1EEV0 T1EEV0 20195102 PTHR24031:SF2 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX55 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG161992|UniProtKB=T1ES46 T1ES46 20199396 PTHR11588:SF6 TUBULIN TUBULIN_FTSZ GTPASE DOMAIN-CONTAINING PROTEIN carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;structural molecule activity#GO:0005198;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;structural constituent of cytoskeleton#GO:0005200 cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;microtubule-based process#GO:0007017;organelle organization#GO:0006996;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;cell cycle#GO:0007049;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 tubulin#PC00228;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG173611|UniProtKB=T1F717 T1F717 20204616 PTHR34009:SF2 PROTEIN STAR PROTEIN STAR localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;endosomal transport#GO:0016197;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987 bounding membrane of organelle#GO:0098588;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;late endosome membrane#GO:0031902;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;endosome membrane#GO:0010008;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle membrane#GO:0030659;endoplasmic reticulum#GO:0005783;late endosome#GO:0005770;plasma membrane#GO:0005886;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG93092|UniProtKB=T1G8T2 T1G8T2 20217479 PTHR36181:SF1 INTRON-ENCODED ENDONUCLEASE AI3-RELATED LAGLIDADG ENDONUCLEASE HELRO|EnsemblGenome=HelroG168863|UniProtKB=T1F124 T1F124 20202524 PTHR11905:SF159 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG80835|UniProtKB=T1G462 T1G462 20215860 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG164579|UniProtKB=T1EVL6 T1EVL6 20200616 PTHR23164:SF29 EARLY ENDOSOME ANTIGEN 1 E3 UBIQUITIN-PROTEIN LIGASE PIB1 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG189170|UniProtKB=T1FQQ9 T1FQQ9 20211156 PTHR23202:SF124 WASP INTERACTING PROTEIN-RELATED C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG165287|UniProtKB=T1EWJ5 T1EWJ5 20200945 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG180225|UniProtKB=T1FFL3 T1FFL3 20207612 PTHR23511:SF34 SYNAPTIC VESICLE GLYCOPROTEIN 2 SYNAPTIC VESICLE GLYCOPROTEIN 2 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG159762|UniProtKB=T1EPD6 T1EPD6 20198436 PTHR46004:SF3 CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 Transcription regulation by bZIP transcription factor#P00055>CREB#P01383;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CREB#P00713 HELRO|EnsemblGenome=HelroG108462|UniProtKB=T1EEJ2 T1EEJ2 20194994 PTHR14149:SF14 RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN nucleoside-triphosphatase regulator activity#GO:0060589;cytoskeletal protein binding#GO:0008092;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;binding#GO:0005488;molecular function regulator activity#GO:0098772;actin filament binding#GO:0051015;protein binding#GO:0005515;calmodulin binding#GO:0005516;protein-containing complex binding#GO:0044877;enzyme activator activity#GO:0008047;actin binding#GO:0003779;enzyme regulator activity#GO:0030234 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cell division#GO:0051301;actomyosin contractile ring assembly#GO:0000915;mitotic cytokinetic process#GO:1902410;cell cycle process#GO:0022402;actomyosin structure organization#GO:0031032;cellular component organization#GO:0016043;cellular process#GO:0009987;cytokinetic process#GO:0032506;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;mitotic cytokinesis#GO:0000281;mitotic cell cycle#GO:0000278;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;cortical cytoskeleton organization#GO:0030865;cytoskeleton-dependent cytokinesis#GO:0061640;actin filament organization#GO:0007015;cell cycle#GO:0007049;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cytokinesis#GO:0000910;cortical actin cytoskeleton organization#GO:0030866 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;cell cortex#GO:0005938;intracellular anatomical structure#GO:0005622 G-protein modulator#PC00022;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG74273|UniProtKB=T1G1P2 T1G1P2 20214990 PTHR21392:SF0 TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 2 TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 2 HELRO|EnsemblGenome=HelroG67701|UniProtKB=T1FZ42 T1FZ42 20214090 PTHR13929:SF0 1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE UBIA PRENYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1 prenyltransferase activity#GO:0004659;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824 cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;small molecule biosynthetic process#GO:0044283;ubiquinone biosynthetic process#GO:0006744;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG106068|UniProtKB=T1EE00 T1EE00 20194802 PTHR11893:SF36 INNEXIN INNEXIN-5 cell junction protein#PC00070;gap junction#PC00105 HELRO|EnsemblGenome=HelroG103179|UniProtKB=T1EDE8 T1EDE8 20194600 PTHR31873:SF6 L-ASPARTATE DEHYDROGENASE-RELATED ASPARTATE DEHYDROGENASE DOMAIN-CONTAINING PROTEIN dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG187316|UniProtKB=T1FP88 T1FP88 20210635 PTHR10352:SF25 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G FOUND IN NEURONS, ISOFORM A-RELATED translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG155947|UniProtKB=T1ELP5 T1ELP5 20197495 PTHR32179:SF3 NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING] NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING] transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;pentosyltransferase activity#GO:0016763;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;dicarboxylic acid metabolic process#GO:0043648;heterocycle catabolic process#GO:0046700;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;organonitrogen compound catabolic process#GO:1901565;purine-containing compound biosynthetic process#GO:0072522;pyridine nucleotide metabolic process#GO:0019362;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;cellular nitrogen compound catabolic process#GO:0044270;phosphate-containing compound metabolic process#GO:0006796;nucleotide biosynthetic process#GO:0009165;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;purine nucleotide metabolic process#GO:0006163;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;nicotinamide nucleotide metabolic process#GO:0046496;cellular nitrogen compound metabolic process#GO:0034641;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;nucleobase-containing compound biosynthetic process#GO:0034654;small molecule catabolic process#GO:0044282;organic cyclic compound catabolic process#GO:1901361;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;carboxylic acid metabolic process#GO:0019752;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185872|UniProtKB=T1FND7 T1FND7 20210334 PTHR46260:SF3 RING-TYPE DOMAIN-CONTAINING PROTEIN RING-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG73105|UniProtKB=T1G1A2 T1G1A2 20214850 PTHR11831:SF1 30S 40S RIBOSOMAL PROTEIN U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3 snoRNA binding#GO:0030515;structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159;rRNA binding#GO:0019843 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;preribosome#GO:0030684;small ribosomal subunit#GO:0015935;ribosome#GO:0005840;90S preribosome#GO:0030686;nuclear protein-containing complex#GO:0140513 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG185018|UniProtKB=T1FMA3 T1FMA3 20209952 PTHR13493:SF3 ZINC FINGER CCHC DOMAIN-CONTAINING RRNA N6-ADENOSINE-METHYLTRANSFERASE ZCCHC4 catalytic activity, acting on RNA#GO:0140098;N-methyltransferase activity#GO:0008170;transferase activity#GO:0016740;rRNA (adenine) methyltransferase activity#GO:0016433;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on a rRNA#GO:0140102;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;rRNA methyltransferase activity#GO:0008649;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;RNA methyltransferase activity#GO:0008173 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA modification#GO:0009451;rRNA modification#GO:0000154;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;ribosome biogenesis#GO:0042254;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;rRNA methylation#GO:0031167;nucleic acid metabolic process#GO:0090304;methylation#GO:0032259;macromolecule methylation#GO:0043414;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;RNA methylation#GO:0001510 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG185555|UniProtKB=T1FMZ2 T1FMZ2 20210191 PTHR46551:SF1 SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN poly(A)+ mRNA export from nucleus#GO:0016973;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;mRNA transport#GO:0051028;RNA localization#GO:0006403;localization#GO:0051179;organic substance transport#GO:0071702;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG156140|UniProtKB=T1ELR9 T1ELR9 20197519 PTHR23074:SF19 AAA DOMAIN-CONTAINING KATANIN P60 ATPASE-CONTAINING SUBUNIT A1 pyrophosphatase activity#GO:0016462;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule-based process#GO:0007017;organelle organization#GO:0006996 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG174771|UniProtKB=T1F8G3 T1F8G3 20205112 PTHR10241:SF29 LETHAL 2 GIANT LARVAE PROTEIN LETHAL(2) GIANT LARVAE PROTEIN nucleoside-triphosphatase regulator activity#GO:0060589;cytoskeletal protein binding#GO:0008092;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;myosin binding#GO:0017022;GTPase activator activity#GO:0005096;molecular function regulator activity#GO:0098772;binding#GO:0005488;syntaxin binding#GO:0019905;protein binding#GO:0005515;enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;SNARE binding#GO:0000149 establishment or maintenance of cell polarity#GO:0007163;cellular localization#GO:0051641;organelle localization#GO:0051640;post-Golgi vesicle-mediated transport#GO:0006892;transport#GO:0006810;establishment of spindle orientation#GO:0051294;regulation of signaling#GO:0023051;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;regulation of Notch signaling pathway#GO:0008593;Golgi to plasma membrane transport#GO:0006893;regulation of biological process#GO:0050789;establishment of cell polarity#GO:0030010;actin filament-based process#GO:0030029;establishment of localization#GO:0051234;secretion#GO:0046903;regulation of signal transduction#GO:0009966;cytoskeleton organization#GO:0007010;establishment of organelle localization#GO:0051656;spindle localization#GO:0051653;secretion by cell#GO:0032940;localization within membrane#GO:0051668;regulation of cell communication#GO:0010646;vesicle-mediated transport to the plasma membrane#GO:0098876;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;establishment of spindle localization#GO:0051293;localization#GO:0051179;regulation of response to stimulus#GO:0048583;cellular component organization or biogenesis#GO:0071840;exocytosis#GO:0006887;microtubule-based process#GO:0007017;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;cortical cytoskeleton organization#GO:0030865;biological regulation#GO:0065007;cell cycle#GO:0007049;establishment of localization in cell#GO:0051649;actin cytoskeleton organization#GO:0030036;export from cell#GO:0140352;cortical actin cytoskeleton organization#GO:0030866 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;cytoskeleton#GO:0005856;cortical actin cytoskeleton#GO:0030864;cellular anatomical entity#GO:0110165;cell cortex#GO:0005938;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG186529|UniProtKB=T1FP07 T1FP07 20210554 PTHR13697:SF4 PHOSPHOFRUCTOKINASE ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;phosphotransferase activity, alcohol group as acceptor#GO:0016773;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;carbohydrate kinase activity#GO:0019200;carbohydrate binding#GO:0030246;kinase activity#GO:0016301;cation binding#GO:0043169;transferase activity#GO:0016740;organic cyclic compound binding#GO:0097159;identical protein binding#GO:0042802;nucleoside phosphate binding#GO:1901265;protein binding#GO:0005515;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;ATP binding#GO:0005524;monosaccharide binding#GO:0048029 ribonucleoside triphosphate metabolic process#GO:0009199;nucleoside triphosphate metabolic process#GO:0009141;heterocycle catabolic process#GO:0046700;ribonucleotide catabolic process#GO:0009261;pyridine nucleotide metabolic process#GO:0019362;nucleobase-containing compound metabolic process#GO:0006139;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;purine ribonucleotide catabolic process#GO:0009154;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;oxoacid metabolic process#GO:0043436;nucleoside phosphate catabolic process#GO:1901292;carbohydrate derivative catabolic process#GO:1901136;purine ribonucleoside triphosphate metabolic process#GO:0009205;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;nucleotide catabolic process#GO:0009166;cellular nitrogen compound metabolic process#GO:0034641;nicotinamide nucleotide metabolic process#GO:0046496;nucleoside diphosphate catabolic process#GO:0009134;organic acid metabolic process#GO:0006082;ribonucleotide metabolic process#GO:0009259;monocarboxylic acid metabolic process#GO:0032787;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;organophosphate catabolic process#GO:0046434;small molecule catabolic process#GO:0044282;glycolytic process#GO:0006096;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;nucleotide metabolic process#GO:0009117;small molecule metabolic process#GO:0044281;cellular aromatic compound metabolic process#GO:0006725;monosaccharide metabolic process#GO:0005996;carbohydrate derivative metabolic process#GO:1901135;organonitrogen compound catabolic process#GO:1901565;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;purine-containing compound catabolic process#GO:0072523;cellular nitrogen compound catabolic process#GO:0044270;purine nucleotide catabolic process#GO:0006195;organic cyclic compound metabolic process#GO:1901360;carbohydrate catabolic process#GO:0016052;nucleoside diphosphate metabolic process#GO:0009132;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carbohydrate metabolic process#GO:0005975;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;heterocycle metabolic process#GO:0046483;organonitrogen compound metabolic process#GO:1901564;cellular process#GO:0009987;glucose metabolic process#GO:0006006;aromatic compound catabolic process#GO:0019439;organic cyclic compound catabolic process#GO:1901361;purine nucleoside triphosphate metabolic process#GO:0009144;hexose metabolic process#GO:0019318;carboxylic acid metabolic process#GO:0019752;nucleobase-containing small molecule metabolic process#GO:0055086 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695 carbohydrate kinase#PC00065 Glycolysis#P00024>Phosphofructokinase-1#P00672 HELRO|EnsemblGenome=HelroG168906|UniProtKB=T1F142 T1F142 20202542 PTHR10682:SF10 POLY A POLYMERASE POLYNUCLEOTIDE ADENYLYLTRANSFERASE adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;mRNA polyadenylation#GO:0006378;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;mRNA 3'-end processing#GO:0031124;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mRNA processing#GO:0006397;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG158302|UniProtKB=T1EMM0 T1EMM0 20197820 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179571|UniProtKB=T1FEW1 T1FEW1 20207360 PTHR44755:SF11 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED ATRIAL NATRIURETIC PEPTIDE RECEPTOR 3 ISOFORM X1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide hormone binding#GO:0017046;hormone binding#GO:0042562;binding#GO:0005488;peptide binding#GO:0042277;amide binding#GO:0033218 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG77448|UniProtKB=T1G2X9 T1G2X9 20215427 PTHR13094:SF1 NADH-UBIQUINONE OXIDOREDUCTASE PDSW SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 10 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transporter complex#GO:1990351;oxidoreductase complex#GO:1990204;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;respirasome#GO:0070469;mitochondrial respiratory chain complex I#GO:0005747;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;transmembrane transporter complex#GO:1902495;mitochondrial respirasome#GO:0005746;membrane-bounded organelle#GO:0043227;respiratory chain complex I#GO:0045271;NADH dehydrogenase complex#GO:0030964;mitochondrial protein-containing complex#GO:0098798 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG157486|UniProtKB=T1EMC1 T1EMC1 20197721 PTHR43149:SF1 ENOYL-COA HYDRATASE DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL lyase#PC00144;hydratase#PC00120 HELRO|EnsemblGenome=HelroG177897|UniProtKB=T1FCF9 T1FCF9 20206508 PTHR10165:SF35 LIPID PHOSPHATE PHOSPHATASE RE23632P hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 lipid metabolic process#GO:0006629;phospholipid dephosphorylation#GO:0046839;dephosphorylation#GO:0016311;cellular metabolic process#GO:0044237;organophosphate metabolic process#GO:0019637;lipid modification#GO:0030258;cellular process#GO:0009987;phospholipid metabolic process#GO:0006644;cellular lipid metabolic process#GO:0044255;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;membrane#GO:0016020 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG75410|UniProtKB=T1G248 T1G248 20215146 PTHR12764:SF4 WD REPEAT DOMAIN-RELATED INTRAFLAGELLAR TRANSPORT PROTEIN 122 HOMOLOG non-motile cilium assembly#GO:1905515;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;cell projection organization#GO:0030030;macromolecule localization#GO:0033036;transport#GO:0006810;microtubule-based movement#GO:0007018;plasma membrane bounded cell projection organization#GO:0120036;protein localization to cilium#GO:0061512;establishment of localization#GO:0051234;cytoskeleton-dependent intracellular transport#GO:0030705;protein localization to organelle#GO:0033365;cellular component assembly#GO:0022607;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cellular process#GO:0009987;intraciliary retrograde transport#GO:0035721;transport along microtubule#GO:0010970;intraciliary transport#GO:0042073;cell projection assembly#GO:0030031;protein localization#GO:0008104;organelle assembly#GO:0070925;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;microtubule-based transport#GO:0099111;cellular macromolecule localization#GO:0070727;microtubule-based process#GO:0007017;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;plasma membrane bounded cell projection assembly#GO:0120031;protein-containing complex localization#GO:0031503 protein-containing complex#GO:0032991;non-motile cilium#GO:0097730;intraciliary transport particle A#GO:0030991;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cilium#GO:0005929;intraciliary transport particle#GO:0030990 HELRO|EnsemblGenome=HelroG65558|UniProtKB=T1FY97 T1FY97 20213795 PTHR11599:SF5 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT BETA TYPE-4 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;proteasome complex#GO:0000502;membrane-bounded organelle#GO:0043227;endopeptidase complex#GO:1905369;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protease#PC00190;protein modifying enzyme#PC00260 Parkinson disease#P00049>20S proteasome#P01227 HELRO|EnsemblGenome=HelroG191922|UniProtKB=T1FTF1 T1FTF1 20212098 PTHR32026:SF10 METHYLTRANSFERASE-LIKE PROTEIN 24 METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG193199|UniProtKB=T1FUQ8 T1FUQ8 20212554 PTHR15706:SF2 SH3 MULTIPLE DOMAIN SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG192217|UniProtKB=T1FTQ1 T1FTQ1 20212198 PTHR10677:SF3 UBIQUILIN FI07626P-RELATED protein binding#GO:0005515;binding#GO:0005488;polyubiquitin modification-dependent protein binding#GO:0031593;modification-dependent protein binding#GO:0140030 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG65151|UniProtKB=T1FY37 T1FY37 20213735 PTHR43442:SF3 GLUCONOKINASE-RELATED GLUCONOKINASE-RELATED transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 oxoacid metabolic process#GO:0043436;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;carbohydrate catabolic process#GO:0016052;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;carbohydrate metabolic process#GO:0005975;carboxylic acid metabolic process#GO:0019752;organic substance metabolic process#GO:0071704;monocarboxylic acid catabolic process#GO:0072329;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;cellular catabolic process#GO:0044248 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 transferase#PC00220;kinase#PC00137;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG83384|UniProtKB=T1G550 T1G550 20216198 PTHR48416:SF1 CYTOCHROME C OXIDASE SUBUNIT 6C CYTOCHROME C OXIDASE SUBUNIT 6C HELRO|EnsemblGenome=HelroG93262|UniProtKB=T1G8U6 T1G8U6 20217493 PTHR11071:SF561 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;catalytic activity#GO:0003824;peptide binding#GO:0042277;amide binding#GO:0033218 macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein peptidyl-prolyl isomerization#GO:0000413;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG66168|UniProtKB=T1FYH9 T1FYH9 20213877 PTHR14097:SF7 OXIDOREDUCTASE HTATIP2 OXIDOREDUCTASE HTATIP2 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG193855|UniProtKB=T1FVF1 T1FVF1 20212797 PTHR13407:SF0 RNF121 PROTEIN FI05221P transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 response to organic substance#GO:0010033;macromolecule catabolic process#GO:0009057;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;response to organonitrogen compound#GO:0010243;ERAD pathway#GO:0036503;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;Golgi membrane#GO:0000139;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG170928|UniProtKB=T1F3L8 T1F3L8 20203417 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG107293|UniProtKB=T1EE94 T1EE94 20194896 PTHR21600:SF83 MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE PSEUDOURIDYLATE SYNTHASE RPUSD4, MITOCHONDRIAL RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG113630|UniProtKB=T1EFU4 T1EFU4 20195446 PTHR12217:SF4 EUKARYOTIC TRANSLATION INITIATION FACTOR 2D EUKARYOTIC TRANSLATION INITIATION FACTOR 2D nucleic acid binding#GO:0003676;translation regulator activity#GO:0045182;translation regulator activity, nucleic acid binding#GO:0090079;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation initiation factor activity#GO:0003743;translation factor activity, RNA binding#GO:0008135 cellular component biogenesis#GO:0044085;peptide metabolic process#GO:0006518;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;translation#GO:0006412;protein-RNA complex assembly#GO:0022618;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cytoplasmic translation#GO:0002181;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;cytoplasmic translational initiation#GO:0002183;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;cellular component organization or biogenesis#GO:0071840;peptide biosynthetic process#GO:0043043;protein-containing complex organization#GO:0043933;ribonucleoprotein complex biogenesis#GO:0022613;translational initiation#GO:0006413;protein-RNA complex organization#GO:0071826 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG159876|UniProtKB=T1EPH4 T1EPH4 20198474 PTHR31362:SF0 GLYCOSYLTRANSFERASE STELLO1-RELATED EXOSTOSIN DOMAIN-CONTAINING PROTEIN-RELATED glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG166495|UniProtKB=T1EY64 T1EY64 20201514 PTHR10309:SF0 MANNOSE-6-PHOSPHATE ISOMERASE MANNOSE-6-PHOSPHATE ISOMERASE isomerase activity#GO:0016853;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;carbohydrate derivative metabolic process#GO:1901135;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleotide-sugar metabolic process#GO:0009225;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;organic cyclic compound metabolic process#GO:1901360;nucleobase-containing compound biosynthetic process#GO:0034654;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 isomerase#PC00135;metabolite interconversion enzyme#PC00262 Mannose metabolism#P02752>Mannose 6-P isomerase#P03017 HELRO|EnsemblGenome=HelroG194856|UniProtKB=T1FWH9 T1FWH9 20213174 PTHR22624:SF52 CYSTEINE PROTEASE ATG4 CYSTEINE PROTEASE cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197 microautophagy#GO:0016237;cellular component biogenesis#GO:0044085;macroautophagy#GO:0016236;macromolecule modification#GO:0043412;mitophagy#GO:0000423;protein modification process#GO:0036211;gene expression#GO:0010467;autophagy of mitochondrion#GO:0000422;biosynthetic process#GO:0009058;post-translational protein modification#GO:0043687;protein processing#GO:0016485;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;cellular component disassembly#GO:0022411;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;mitochondrion organization#GO:0007005;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organelle disassembly#GO:1903008;lipoprotein biosynthetic process#GO:0042158;primary metabolic process#GO:0044238;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;autophagosome assembly#GO:0000045;lipoprotein metabolic process#GO:0042157;autophagy#GO:0006914;piecemeal microautophagy of the nucleus#GO:0034727 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG81669|UniProtKB=T1G4H1 T1G4H1 20215969 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG84013|UniProtKB=T1G5D2 T1G5D2 20216279 PTHR13479:SF40 30S RIBOSOMAL PROTEIN S18 SMALL RIBOSOMAL SUBUNIT PROTEIN BS18M structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159;rRNA binding#GO:0019843 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;translation#GO:0006412;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG191022|UniProtKB=T1FSI4 T1FSI4 20211781 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cell communication#GO:0007154;cellular process#GO:0009987;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;Notch signaling pathway#GO:0007219 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG67782|UniProtKB=T1FZ51 T1FZ51 20214099 PTHR10218:SF362 GTP-BINDING PROTEIN ALPHA SUBUNIT G PROTEIN ALPHA O SUBUNIT GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;ribonucleoside triphosphate phosphatase activity#GO:0017111;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 regulation of biological process#GO:0050789;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;side of membrane#GO:0098552;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;extrinsic component of membrane#GO:0019898 heterotrimeric G-protein#PC00117;G-protein#PC00020 Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Enkephalin release#P05913>G-Protein (i)#P05974;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;Opioid prodynorphin pathway#P05916>G-protein#P06002;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047 HELRO|EnsemblGenome=HelroG84103|UniProtKB=T1G5E8 T1G5E8 20216295 PTHR22916:SF3 GLYCOSYLTRANSFERASE UDP-GLCNAC:BETAGAL BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE-LIKE PROTEIN 1 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG122109|UniProtKB=T1EGU0 T1EGU0 20195790 PTHR11537:SF252 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;delayed rectifier potassium channel activity#GO:0005251;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG191166|UniProtKB=T1FSP3 T1FSP3 20211840 PTHR13173:SF10 WW DOMAIN BINDING PROTEIN 4 WW DOMAIN-BINDING PROTEIN 4 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;precatalytic spliceosome#GO:0071011;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG69120|UniProtKB=T1FZP9 T1FZP9 20214297 PTHR23048:SF0 MYOSIN LIGHT CHAIN 1, 3 CALMODULIN LIKE 3 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;myosin complex#GO:0016459;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG166364|UniProtKB=T1EY22 T1EY22 20201472 PTHR19325:SF575 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING LOCOMOTION-RELATED PROTEIN HIKARU GENKI complement component#PC00078 HELRO|EnsemblGenome=HelroG184328|UniProtKB=T1FL04 T1FL04 20209503 PTHR12619:SF5 RFX TRANSCRIPTION FACTOR FAMILY TRANSCRIPTION FACTOR RFX4 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG173171|UniProtKB=T1F6I1 T1F6I1 20204430 PTHR37162:SF1 HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED BED-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164658|UniProtKB=T1EVP4 T1EVP4 20200644 PTHR24134:SF9 ANKYRIN REPEAT-CONTAINING PROTEIN DDB_G0279043 ANKYRIN REPEAT AND SOCS BOX PROTEIN 8 HELRO|EnsemblGenome=HelroG159530|UniProtKB=T1EP50 T1EP50 20198350 PTHR46954:SF1 C2H2-TYPE DOMAIN-CONTAINING PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG134015|UniProtKB=T1EI31 T1EI31 20196231 PTHR19134:SF562 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE PROTEIN-TYROSINE-PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG88186|UniProtKB=T1G6Z5 T1G6Z5 20216842 PTHR13306:SF6 TRANSMEMBRANE PROTEIN 138 TRANSMEMBRANE PROTEIN 138 membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cilium#GO:0005929;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025 HELRO|EnsemblGenome=HelroG192681|UniProtKB=T1FU67 T1FU67 20212363 PTHR24006:SF925 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITINYL HYDROLASE 1 cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG192654|UniProtKB=T1FU59 T1FU59 20212355 PTHR14387:SF0 THADA/DEATH RECEPTOR INTERACTING PROTEIN DUF2428 DOMAIN-CONTAINING PROTEIN cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;macromolecule methylation#GO:0043414;tRNA methylation#GO:0030488;organic cyclic compound metabolic process#GO:1901360;methylation#GO:0032259;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;RNA methylation#GO:0001510;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185068|UniProtKB=T1FMC8 T1FMC8 20209977 PTHR11596:SF5 ALKALINE PHOSPHATASE ALKALINE PHOSPHATASE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 cellular metabolic process#GO:0044237;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;dephosphorylation#GO:0016311;metabolic process#GO:0008152 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG193550|UniProtKB=T1FV42 T1FV42 20212688 PTHR10807:SF110 MYOTUBULARIN-RELATED FI17948P1 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 lipid metabolic process#GO:0006629;phospholipid dephosphorylation#GO:0046839;phosphatidylinositol dephosphorylation#GO:0046856;cellular metabolic process#GO:0044237;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;lipid modification#GO:0030258;cellular process#GO:0009987;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;dephosphorylation#GO:0016311;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG184203|UniProtKB=T1FKR5 T1FKR5 20209414 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159443|UniProtKB=T1EP15 T1EP15 20198315 PTHR11440:SF97 LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED BCDNA.GH02384 acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG179427|UniProtKB=T1FEP2 T1FEP2 20207291 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG160718|UniProtKB=T1EQM9 T1EQM9 20198879 PTHR14191:SF3 PDZ DOMAIN CONTAINING PROTEIN NA(+)_H(+) EXCHANGE REGULATORY COFACTOR-LIKE PROTEIN NRFL-1 protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 localization#GO:0051179;protein localization to plasma membrane#GO:0072659;protein localization to cell periphery#GO:1990778;localization within membrane#GO:0051668;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;cellular process#GO:0009987;protein localization#GO:0008104 plasma membrane region#GO:0098590;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;apical part of cell#GO:0045177;plasma membrane#GO:0005886;apical plasma membrane#GO:0016324 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG164375|UniProtKB=T1EVC3 T1EVC3 20200523 PTHR10913:SF45 FOLLISTATIN-RELATED FOLLISTATIN, ISOFORM A-RELATED cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG91967|UniProtKB=T1G8B1 T1G8B1 20217308 PTHR12411:SF947 CYSTEINE PROTEASE FAMILY C1-RELATED DIPEPTIDYL PEPTIDASE 1 cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197 macromolecule catabolic process#GO:0009057;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;proteolysis#GO:0006508;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;catabolic process#GO:0009056;organonitrogen compound catabolic process#GO:1901565;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;lysosome#GO:0005764;intracellular membrane-bounded organelle#GO:0043231;extracellular region#GO:0005576;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;organelle#GO:0043226;lytic vacuole#GO:0000323;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG168052|UniProtKB=T1F040 T1F040 20202190 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183408|UniProtKB=T1FJL1 T1FJL1 20209010 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG170743|UniProtKB=T1F3D7 T1F3D7 20203336 PTHR28360:SF1 DYNACTIN SUBUNIT 3 DYNACTIN SUBUNIT 3 cell cycle process#GO:0022402;cytoskeleton-dependent cytokinesis#GO:0061640;cell cycle#GO:0007049;cell division#GO:0051301;cellular process#GO:0009987;cytokinesis#GO:0000910 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG78021|UniProtKB=T1G368 T1G368 20215516 PTHR44216:SF3 PROTEIN O-MANNOSYL-TRANSFERASE TMTC2 PROTEIN O-MANNOSYL-TRANSFERASE TMTC2 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG98567|UniProtKB=T1G9N7 T1G9N7 20217783 PTHR10829:SF29 CORTACTIN AND DREBRIN COACTOSIN-LIKE PROTEIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 regulation of anatomical structure size#GO:0090066;regulation of actin filament length#GO:0030832;regulation of organelle organization#GO:0033043;regulation of actin filament organization#GO:0110053;regulation of cellular component organization#GO:0051128;cellular component organization#GO:0016043;regulation of actin polymerization or depolymerization#GO:0008064;cellular process#GO:0009987;regulation of actin filament polymerization#GO:0030833;regulation of cellular component size#GO:0032535;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cytoskeleton organization#GO:0051493;regulation of protein-containing complex assembly#GO:0043254;regulation of biological quality#GO:0065008;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament-based process#GO:0032970;regulation of protein polymerization#GO:0032271 supramolecular complex#GO:0099080;cortical cytoskeleton#GO:0030863;supramolecular polymer#GO:0099081;cellular anatomical entity#GO:0110165;cell cortex#GO:0005938;cell periphery#GO:0071944;supramolecular fiber#GO:0099512;cortical actin cytoskeleton#GO:0030864;organelle#GO:0043226;actin filament#GO:0005884;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;site of polarized growth#GO:0030427 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG192813|UniProtKB=T1FUB8 T1FUB8 20212414 PTHR14494:SF0 ALADIN/ADRACALIN/AAAS ALADIN localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;transport#GO:0006810;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular process#GO:0009987;nuclear transport#GO:0051169 envelope#GO:0031975;nuclear pore#GO:0005643;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG63427|UniProtKB=T1FXF8 T1FXF8 20213506 PTHR15371:SF0 TIM23 SD19278P protein transmembrane transporter activity#GO:0008320;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular localization#GO:0051641;transmembrane transport#GO:0055085;macromolecule localization#GO:0033036;transport#GO:0006810;protein transmembrane transport#GO:0071806;protein targeting#GO:0006605;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;protein localization to mitochondrion#GO:0070585;cellular process#GO:0009987;protein transmembrane import into intracellular organelle#GO:0044743;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;mitochondrial transport#GO:0006839;organic substance transport#GO:0071702;protein import into mitochondrial matrix#GO:0030150;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein targeting to mitochondrion#GO:0006626;establishment of protein localization to mitochondrion#GO:0072655;protein transport#GO:0015031;protein localization to organelle#GO:0033365;mitochondrial transmembrane transport#GO:1990542 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;TIM23 mitochondrial import inner membrane translocase complex#GO:0005744;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;mitochondrial protein-containing complex#GO:0098798 amino acid transporter#PC00046;transporter#PC00227 HELRO|EnsemblGenome=HelroG183688|UniProtKB=T1FK15 T1FK15 20209164 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG174240|UniProtKB=T1F7V1 T1F7V1 20204900 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG102315|UniProtKB=T1ED94 T1ED94 20194546 PTHR15301:SF3 INSULIN-INDUCED GENE 1 PROTEIN NSG1-RELATED sterol metabolic process#GO:0016125;organic hydroxy compound metabolic process#GO:1901615;lipid metabolic process#GO:0006629;steroid metabolic process#GO:0008202;organic cyclic compound metabolic process#GO:1901360;organic hydroxy compound biosynthetic process#GO:1901617;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;lipid biosynthetic process#GO:0008610;steroid biosynthetic process#GO:0006694;metabolic process#GO:0008152;sterol biosynthetic process#GO:0016126;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG167313|UniProtKB=T1EZ91 T1EZ91 20201891 PTHR25462:SF300 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG179072|UniProtKB=T1FE53 T1FE53 20207102 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191984|UniProtKB=T1FTH6 T1FTH6 20212123 PTHR24016:SF0 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG158358|UniProtKB=T1EMP5 T1EMP5 20197845 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192632|UniProtKB=T1FU53 T1FU53 20212349 PTHR31139:SF4 ECTOPIC P GRANULES PROTEIN 5 HOMOLOG ECTOPIC P GRANULES PROTEIN 5 HOMOLOG process utilizing autophagic mechanism#GO:0061919;cellular component organization or biogenesis#GO:0071840;cellular component disassembly#GO:0022411;protein-containing complex disassembly#GO:0032984;macroautophagy#GO:0016236;protein-containing complex organization#GO:0043933;catabolic process#GO:0009056;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;autophagosome maturation#GO:0097352;cellular process#GO:0009987;autophagy#GO:0006914;cellular catabolic process#GO:0044248;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG112750|UniProtKB=T1EFL9 T1EFL9 20195371 PTHR22767:SF2 N-TERMINAL ACETYLTRANSFERASE-RELATED N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;peptidyl-amino acid modification#GO:0018193;protein acylation#GO:0043543;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein acetylation#GO:0006473;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG90419|UniProtKB=T1G7R2 T1G7R2 20217109 PTHR11538:SF40 PHENYLALANYL-TRNA SYNTHETASE PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 aminoacyl-tRNA synthetase#PC00047 HELRO|EnsemblGenome=HelroG190692|UniProtKB=T1FS75 T1FS75 20211672 PTHR16055:SF2 INTEGRATOR COMPLEX SUBUNIT 10 INTEGRATOR COMPLEX SUBUNIT 10 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;snRNA metabolic process#GO:0016073;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;snRNA processing#GO:0016180;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;integrator complex#GO:0032039 HELRO|EnsemblGenome=HelroG171049|UniProtKB=T1F3R1 T1F3R1 20203460 PTHR15955:SF8 RWD DOMAIN CONTAINING PROTEIN 2 RWD DOMAIN-CONTAINING PROTEIN 2B-RELATED ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG167265|UniProtKB=T1EZ69 T1EZ69 20201869 PTHR46437:SF1 MORN REPEAT-CONTAINING PROTEIN 5 MORN REPEAT-CONTAINING PROTEIN 5 HELRO|EnsemblGenome=HelroG72310|UniProtKB=T1G0Y1 T1G0Y1 20214729 PTHR28554:SF1 39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN ML45 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG124468|UniProtKB=T1EH16 T1EH16 20195866 PTHR11662:SF399 SOLUTE CARRIER FAMILY 17 FI19708P1-RELATED secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG116413|UniProtKB=T1EGE8 T1EGE8 20195650 PTHR12027:SF77 WNT RELATED PROTEIN WNT-5 molecular function activator activity#GO:0140677;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;protein binding#GO:0005515;cytokine activity#GO:0005125;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;neurogenesis#GO:0022008;developmental process#GO:0032502;multicellular organism development#GO:0007275;cell communication#GO:0007154;cell fate commitment#GO:0045165;cell-cell signaling by wnt#GO:0198738;nervous system development#GO:0007399;cellular process#GO:0009987;regulation of biological process#GO:0050789;system development#GO:0048731;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;cell-cell signaling#GO:0007267;signaling#GO:0023052;canonical Wnt signaling pathway#GO:0060070;Wnt signaling pathway#GO:0016055 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Angiogenesis#P00005>Wnt#P00206;Cadherin signaling pathway#P00012>Wnt#P00474 HELRO|EnsemblGenome=HelroG98619|UniProtKB=T1G9N8 T1G9N8 20217784 PTHR24339:SF28 HOMEOBOX PROTEIN EMX-RELATED E5-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG193897|UniProtKB=T1FVG5 T1FVG5 20212811 PTHR13236:SF0 DYNEIN 2 LIGHT INTERMEDIATE CHAIN, ISOFORM 2 CYTOPLASMIC DYNEIN 2 LIGHT INTERMEDIATE CHAIN 1 protein binding#GO:0005515;binding#GO:0005488 cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;cilium assembly#GO:0060271;cell projection organization#GO:0030030;transport#GO:0006810;microtubule-based movement#GO:0007018;cellular component organization#GO:0016043;intraciliary transport involved in cilium assembly#GO:0035735;intraciliary retrograde transport#GO:0035721;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;transport along microtubule#GO:0010970;cell projection assembly#GO:0030031;intraciliary transport#GO:0042073;localization#GO:0051179;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based transport#GO:0099111;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;organelle organization#GO:0006996;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;plasma membrane bounded cell projection assembly#GO:0120031;protein-containing complex localization#GO:0031503 axoneme#GO:0005930;microtubule organizing center#GO:0005815;catalytic complex#GO:1902494;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;microtubule associated complex#GO:0005875;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;ciliary plasm#GO:0097014;plasma membrane bounded cell projection cytoplasm#GO:0032838;membrane-bounded organelle#GO:0043227;dynein complex#GO:0030286;cell projection#GO:0042995;cytoskeleton#GO:0005856;cilium#GO:0005929;cytoplasmic dynein complex#GO:0005868 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG181360|UniProtKB=T1FGX4 T1FGX4 20208073 PTHR10288:SF338 KH DOMAIN CONTAINING RNA BINDING PROTEIN IGF-II MRNA-BINDING PROTEIN, ISOFORM L nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159;mRNA 3'-UTR binding#GO:0003730 developmental process#GO:0032502;multicellular organism development#GO:0007275;nervous system development#GO:0007399;regulation of biological process#GO:0050789;system development#GO:0048731;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG122890|UniProtKB=T1EGW3 T1EGW3 20195813 PTHR24072:SF142 RHO FAMILY GTPASE RHOU, ISOFORM B GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;enzyme binding#GO:0019899;ribonucleoside triphosphate phosphatase activity#GO:0017111;kinase binding#GO:0019900;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817;protein kinase binding#GO:0019901;anion binding#GO:0043168;ion binding#GO:0043167 establishment or maintenance of cell polarity#GO:0007163;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;small GTPase-mediated signal transduction#GO:0007264;transport#GO:0006810;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cell communication#GO:0007154;cellular process#GO:0009987;Rho protein signal transduction#GO:0007266;localization#GO:0051179;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;establishment of cell polarity#GO:0030010;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;intracellular signal transduction#GO:0035556;import into cell#GO:0098657;signaling#GO:0023052 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG183230|UniProtKB=T1FJC6 T1FJC6 20208925 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG171152|UniProtKB=T1F3V5 T1F3V5 20203504 PTHR12694:SF8 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;gene expression#GO:0010467;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 RNA metabolism protein#PC00031;general transcription factor#PC00259 General transcription regulation#P00023>TFIIA complex#P00662;Transcription regulation by bZIP transcription factor#P00055>TFIIA complex#P01390 HELRO|EnsemblGenome=HelroG168898|UniProtKB=T1F140 T1F140 20202540 PTHR24044:SF502 NOTCH LIGAND FAMILY MEMBER ANTERIOR PHARYNX IN EXCESS PROTEIN 1-RELATED protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG109918|UniProtKB=T1EEX3 T1EEX3 20195125 PTHR10336:SF36 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4 hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phospholipase C activity#GO:0004629;phospholipase activity#GO:0004620;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;negative regulation of biological process#GO:0048519;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of sequestering of calcium ion#GO:0051282;release of sequestered calcium ion into cytosol#GO:0051209;regulation of localization#GO:0032879;cell communication#GO:0007154;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;calcium ion transport#GO:0006816;localization#GO:0051179;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;calcium ion transmembrane import into cytosol#GO:0097553;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;intracellular signal transduction#GO:0035556;monoatomic ion transport#GO:0006811;negative regulation of sequestering of calcium ion#GO:0051283;signaling#GO:0023052;monoatomic cation transmembrane transport#GO:0098655;negative regulation of cellular process#GO:0048523 phospholipase#PC00186 Metabotropic glutamate receptor group I pathway#P00041>PLC#P01053;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PLCbetagamma#P00874;Wnt signaling pathway#P00057>Phospholipase C#P01443;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>PLC#P01068;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PLC#P04581;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Phospholipase C-beta#P00744;EGF receptor signaling pathway#P00018>PLCgamma#P00556;Endothelin signaling pathway#P00019>PLCbeta#P00591;Alpha adrenergic receptor signaling pathway#P00002>PLC#P00073;Oxytocin receptor mediated signaling pathway#P04391>PLC beta#P04530;5HT2 type receptor mediated signaling pathway#P04374>PLC#P04412;Histamine H1 receptor mediated signaling pathway#P04385>PLC#P04484 HELRO|EnsemblGenome=HelroG191168|UniProtKB=T1FSP5 T1FSP5 20211842 PTHR31220:SF1 HYCCIN RELATED GH21176P lipid metabolic process#GO:0006629;cellular localization#GO:0051641;phospholipid biosynthetic process#GO:0008654;macromolecule localization#GO:0033036;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;protein localization to plasma membrane#GO:0072659;localization within membrane#GO:0051668;protein localization to membrane#GO:0072657;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;protein localization to cell periphery#GO:1990778;cellular macromolecule localization#GO:0070727;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG192012|UniProtKB=T1FTI3 T1FTI3 20212130 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED FMRFAMIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG185380|UniProtKB=T1FMQ8 T1FMQ8 20210107 PTHR13373:SF21 FROUNT PROTEIN-RELATED NUCLEAR PORE COMPLEX PROTEIN NUP85 structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056 cellular localization#GO:0051641;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;regulation of RNA biosynthetic process#GO:2001141;establishment of protein localization#GO:0045184;RNA localization#GO:0006403;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;RNA transport#GO:0050658;positive regulation of biological process#GO:0048518;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;positive regulation of macromolecule metabolic process#GO:0010604;protein localization#GO:0008104;positive regulation of cellular process#GO:0048522;cellular macromolecule localization#GO:0070727;nuclear export#GO:0051168;regulation of cellular process#GO:0050794;protein transport#GO:0015031;intracellular transport#GO:0046907;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;positive regulation of nitrogen compound metabolic process#GO:0051173;macromolecule localization#GO:0033036;positive regulation of RNA biosynthetic process#GO:1902680;transport#GO:0006810;protein localization to nucleus#GO:0034504;nucleic acid transport#GO:0050657;biosynthetic process#GO:0009058;positive regulation of biosynthetic process#GO:0009891;protein import into nucleus#GO:0006606;organic substance transport#GO:0071702;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;protein localization to organelle#GO:0033365;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;metabolic process#GO:0008152;mRNA export from nucleus#GO:0006406;macromolecule biosynthetic process#GO:0009059;regulation of DNA-templated transcription#GO:0006355;establishment of protein localization to organelle#GO:0072594;cellular biosynthetic process#GO:0044249;positive regulation of cellular biosynthetic process#GO:0031328;organic substance biosynthetic process#GO:1901576;mRNA transport#GO:0051028;cellular process#GO:0009987;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;localization#GO:0051179;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;nucleocytoplasmic transport#GO:0006913;regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleobase-containing compound transport#GO:0015931;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;positive regulation of RNA metabolic process#GO:0051254;RNA export from nucleus#GO:0006405;import into nucleus#GO:0051170 envelope#GO:0031975;nuclear pore#GO:0005643;protein-containing complex#GO:0032991;nucleus#GO:0005634;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 structural protein#PC00211 HELRO|EnsemblGenome=HelroG157714|UniProtKB=T1EME6 T1EME6 20197746 PTHR11153:SF8 SIDEROFLEXIN SIDEROFLEXIN-1 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 neutral amino acid transport#GO:0015804;transmembrane transport#GO:0055085;organic anion transport#GO:0015711;amino acid transport#GO:0006865;organic acid transport#GO:0015849;transport#GO:0006810;nitrogen compound transport#GO:0071705;carboxylic acid transport#GO:0046942;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039;mitochondrial transport#GO:0006839;localization#GO:0051179;organic substance transport#GO:0071702;amino acid transmembrane transport#GO:0003333;establishment of localization#GO:0051234;organic acid transmembrane transport#GO:1903825;mitochondrial transmembrane transport#GO:1990542 envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;organelle inner membrane#GO:0019866;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG90391|UniProtKB=T1G7Q5 T1G7Q5 20217102 PTHR47611:SF3 HAT DIMERISATION DOMAIN, C-TERMINAL HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG155178|UniProtKB=T1ELH5 T1ELH5 20197425 PTHR16317:SF1 INTEGRIN ALPHA REPEAT DOMAIN-CONTAINING KICSTOR COMPLEX PROTEIN ITFG2 regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;regulation of signaling#GO:0023051;biological regulation#GO:0065007;regulation of intracellular signal transduction#GO:1902531;regulation of TOR signaling#GO:0032006 protein-containing complex#GO:0032991 cell adhesion molecule#PC00069;integrin#PC00126 HELRO|EnsemblGenome=HelroG74833|UniProtKB=T1G1W2 T1G1W2 20215060 PTHR14592:SF14 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG91356|UniProtKB=T1G829 T1G829 20217226 PTHR31134:SF1 TRANSMEMBRANE PROTEIN 128 TRANSMEMBRANE PROTEIN 128 HELRO|EnsemblGenome=HelroG95841|UniProtKB=T1G981 T1G981 20217628 PTHR45720:SF10 CHLORIDE CHANNEL PROTEIN 2 CHLORIDE CHANNEL PROTEIN 2 voltage-gated monoatomic ion channel activity#GO:0005244;inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267 localization#GO:0051179;chloride transport#GO:0006821;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;inorganic anion transport#GO:0015698;monoatomic anion transport#GO:0006820;transport#GO:0006810 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG182722|UniProtKB=T1FIN2 T1FIN2 20208681 PTHR10075:SF100 BASIGIN RELATED FASCICLIN-2 cell adhesion molecule binding#GO:0050839;cell-cell adhesion mediator activity#GO:0098632;protein binding#GO:0005515;binding#GO:0005488 neuron projection guidance#GO:0097485;cell recognition#GO:0008037;neurogenesis#GO:0022008;cell projection organization#GO:0030030;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;axonogenesis#GO:0007409;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156;cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cell morphogenesis#GO:0000902;cellular process#GO:0009987;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure development#GO:0048856;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;axon#GO:0030424 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG80699|UniProtKB=T1G440 T1G440 20215838 PTHR10736:SF65 BESTROPHIN BESTROPHIN 1, ISOFORM C-RELATED inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;channel activity#GO:0015267 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG191255|UniProtKB=T1FST1 T1FST1 20211878 PTHR12708:SF0 DNA POLYMERASE EPSILON SUBUNIT B DNA POLYMERASE EPSILON SUBUNIT 2 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated DNA replication#GO:0006261;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;postreplication repair#GO:0006301;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;translesion synthesis#GO:0019985;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;nucleobase-containing compound biosynthetic process#GO:0034654;DNA biosynthetic process#GO:0071897;DNA synthesis involved in DNA repair#GO:0000731;aromatic compound biosynthetic process#GO:0019438;cellular response to stress#GO:0033554;DNA replication#GO:0006260;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;epsilon DNA polymerase complex#GO:0008622;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;DNA polymerase complex#GO:0042575;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 DNA-directed DNA polymerase#PC00018 HELRO|EnsemblGenome=HelroG175131|UniProtKB=T1F8W4 T1F8W4 20205263 PTHR10019:SF12 SNF5 PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 protein-DNA complex organization#GO:0071824;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;cellular component organization#GO:0016043;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG84047|UniProtKB=T1G5D9 T1G5D9 20216286 PTHR24089:SF57 SOLUTE CARRIER FAMILY 25 FI05451P carbohydrate derivative transmembrane transporter activity#GO:1901505;purine nucleotide transmembrane transporter activity#GO:0015216;nucleobase-containing compound transmembrane transporter activity#GO:0015932;transmembrane transporter activity#GO:0022857;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215 localization#GO:0051179;organic substance transport#GO:0071702;organophosphate ester transport#GO:0015748;establishment of localization#GO:0051234;organic anion transport#GO:0015711;nucleobase-containing compound transport#GO:0015931;transport#GO:0006810;nitrogen compound transport#GO:0071705;carbohydrate derivative transport#GO:1901264 mitochondrial carrier protein#PC00158;secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG149824|UniProtKB=T1EKD7 T1EKD7 20197037 PTHR11654:SF509 OLIGOPEPTIDE TRANSPORTER-RELATED SOLUTE CARRIER FAMILY 15 MEMBER 4 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG74560|UniProtKB=T1G1S7 T1G1S7 20215025 PTHR10281:SF106 MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED IP06960P-RELATED cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG86541|UniProtKB=T1G6D7 T1G6D7 20216634 PTHR16515:SF66 PR DOMAIN ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG190006|UniProtKB=T1FRL0 T1FRL0 20211457 PTHR13017:SF0 5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE-RELATED METHENYLTETRAHYDROFOLATE SYNTHASE DOMAIN-CONTAINING PROTEIN cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ligase#PC00142 HELRO|EnsemblGenome=HelroG113964|UniProtKB=T1EFX7 T1EFX7 20195479 PTHR23127:SF0 CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5 H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1 isomerase activity#GO:0016853;intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA modification#GO:0009451;rRNA modification#GO:0000154;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;ribosome biogenesis#GO:0042254;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;snRNA metabolic process#GO:0016073;macromolecule biosynthetic process#GO:0009059;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;mRNA modification#GO:0016556;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;pseudouridine synthesis#GO:0001522;nucleic acid metabolic process#GO:0090304;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613 centromere DNA-binding protein#PC00071 HELRO|EnsemblGenome=HelroG155694|UniProtKB=T1ELK8 T1ELK8 20197458 PTHR11753:SF5 ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY AP COMPLEX SUBUNIT SIGMA localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;cellular process#GO:0009987;transport#GO:0006810 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG191266|UniProtKB=T1FST4 T1FST4 20211881 PTHR24366:SF96 IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS LEUCINE RICH REPEAT CONTAINING 53 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG173574|UniProtKB=T1F6Z3 T1F6Z3 20204592 PTHR10494:SF6 BONE MORPHOGENETIC PROTEIN INHIBITOR, NOGGIN NOGGIN regulation of cell communication#GO:0010646;cellular developmental process#GO:0048869;negative regulation of biological process#GO:0048519;negative regulation of response to stimulus#GO:0048585;ossification#GO:0001503;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;developmental process#GO:0032502;osteoblast differentiation#GO:0001649;cellular process#GO:0009987;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of BMP signaling pathway#GO:0030510;cell differentiation#GO:0030154;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;negative regulation of BMP signaling pathway#GO:0030514;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cellular response to growth factor stimulus#GO:0090287;negative regulation of signal transduction#GO:0009968;multicellular organismal process#GO:0032501;negative regulation of cell communication#GO:0010648;negative regulation of cellular process#GO:0048523 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG166784|UniProtKB=T1EYI9 T1EYI9 20201639 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162063|UniProtKB=T1ES76 T1ES76 20199426 PTHR47533:SF4 PROTEIN CBG21859 AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184146|UniProtKB=T1FKN7 T1FKN7 20209386 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG177674|UniProtKB=T1FC20 T1FC20 20206369 PTHR21461:SF69 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 glycosylation#GO:0070085;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG186232|UniProtKB=T1FNU6 T1FNU6 20210493 PTHR10229:SF0 GTP-BINDING PROTEIN HFLX GTP-BINDING PROTEIN 6-RELATED ribonucleoprotein complex binding#GO:0043021;ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877;binding#GO:0005488 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG158475|UniProtKB=T1EMU5 T1EMU5 20197895 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG76804|UniProtKB=T1G2P6 T1G2P6 20215344 PTHR24185:SF1 CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;phospholipase activity#GO:0004620;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;oxoacid metabolic process#GO:0043436;fatty acid metabolic process#GO:0006631;cellular metabolic process#GO:0044237;cellular process#GO:0009987;cellular lipid metabolic process#GO:0044255;organic acid metabolic process#GO:0006082;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;membrane#GO:0016020 phospholipase#PC00186;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG162440|UniProtKB=T1ESN4 T1ESN4 20199584 PTHR15592:SF27 MATRIN 3/NUCLEAR PROTEIN 220-RELATED HEPHAESTUS, ISOFORM Y nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nitrogen compound metabolic process#GO:0051171;regulation of biosynthetic process#GO:0009889;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG163906|UniProtKB=T1EUL7 T1EUL7 20200267 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG155336|UniProtKB=T1ELH9 T1ELH9 20197429 PTHR19305:SF14 SYNAPTOSOMAL ASSOCIATED PROTEIN SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED syntaxin binding#GO:0019905;molecular adaptor activity#GO:0060090;protein binding#GO:0005515;SNAP receptor activity#GO:0005484;binding#GO:0005488;SNARE binding#GO:0000149;protein-macromolecule adaptor activity#GO:0030674 vesicle fusion#GO:0006906;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;synaptic vesicle cycle#GO:0099504;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;protein-containing complex assembly#GO:0065003;endomembrane system organization#GO:0010256;regulation of biological process#GO:0050789;regulated exocytosis#GO:0045055;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;secretion#GO:0046903;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;signal release#GO:0023061;vesicle organization#GO:0016050;cell-cell signaling#GO:0007267;signaling#GO:0023052;synaptic vesicle exocytosis#GO:0016079;secretion by cell#GO:0032940;organelle fusion#GO:0048284;vesicle fusion to plasma membrane#GO:0099500;neurotransmitter secretion#GO:0007269;cellular component assembly#GO:0022607;trans-synaptic signaling#GO:0099537;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cell communication#GO:0007154;cellular process#GO:0009987;exocytic process#GO:0140029;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;signal release from synapse#GO:0099643;membrane fusion#GO:0061025;exocytosis#GO:0006887;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;export from cell#GO:0140352;vesicle-mediated transport in synapse#GO:0099003 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;SNARE complex#GO:0031201;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034 Synaptic vesicle trafficking#P05734>SNAP-25#P05778;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066;Opioid proenkephalin pathway#P05915>SNARE Complex#P05986;Thyrotropin-releasing hormone receptor signaling pathway#P04394>SNARE Complex#P04582;Dopamine receptor mediated signaling pathway#P05912>SNARE Complex#P05956;Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072;Beta3 adrenergic receptor signaling pathway#P04379>SNARE Complex#P04447;5HT4 type receptor mediated signaling pathway#P04376>SNARE Complex#P04428;Opioid prodynorphin pathway#P05916>SNARE Complex#P05996;Alpha adrenergic receptor signaling pathway#P00002>SNARE#P00074;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;5HT3 type receptor mediated signaling pathway#P04375>SNARE Complex#P04423;Ionotropic glutamate receptor pathway#P00037>SNARE Complex#P01013;Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049;Opioid proopiomelanocortin pathway#P05917>SNARE Complex#P06005;Cortocotropin releasing factor receptor signaling pathway#P04380>SNARE Complex#P04457;Beta1 adrenergic receptor signaling pathway#P04377>SNARE Complex#P04435;Oxytocin receptor mediated signaling pathway#P04391>SNARE Complex#P04532;Metabotropic glutamate receptor group III pathway#P00039>SNARE Complex#P01042;5HT2 type receptor mediated signaling pathway#P04374>SNARE Complex#P04415;5HT1 type receptor mediated signaling pathway#P04373>SNARE Complex#P04405;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;Beta2 adrenergic receptor signaling pathway#P04378>SNARE Complex#P04442 HELRO|EnsemblGenome=HelroG99303|UniProtKB=T1G9S1 T1G9S1 20217817 PTHR11142:SF5 PSEUDOURIDYLATE SYNTHASE TRNA PSEUDOURIDINE(38_39) SYNTHASE isomerase activity#GO:0016853;intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;mRNA modification#GO:0016556;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;pseudouridine synthesis#GO:0001522;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 lyase#PC00144 HELRO|EnsemblGenome=HelroG172169|UniProtKB=T1F539 T1F539 20203938 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG82550|UniProtKB=T1G4T8 T1G4T8 20216086 PTHR45897:SF4 HIGH-AFFINITY CHOLINE TRANSPORTER 1 HIGH-AFFINITY CHOLINE TRANSPORTER 1 inorganic molecular entity transmembrane transporter activity#GO:0015318;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;sodium ion transmembrane transporter activity#GO:0015081;organic cation transmembrane transporter activity#GO:0015101;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 Nicotinic acetylcholine receptor signaling pathway#P00044>CHT1#P01098;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>CHT1#P01084;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>CHT1#P01072 HELRO|EnsemblGenome=HelroG194715|UniProtKB=T1FWC3 T1FWC3 20213118 PTHR10697:SF13 MAMMALIAN EPENDYMIN-RELATED PROTEIN 1 RICIN B LECTIN DOMAIN-CONTAINING PROTEIN cytoplasm#GO:0005737;lysosome#GO:0005764;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;vacuole#GO:0005773;cellular anatomical entity#GO:0110165;lytic vacuole#GO:0000323;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG167437|UniProtKB=T1EZD5 T1EZD5 20201935 PTHR21533:SF19 LEUCINE-RICH PROTEIN LEUCINE-RICH PROTEIN HELRO|EnsemblGenome=HelroG165002|UniProtKB=T1EW37 T1EW37 20200787 PTHR36191:SF1 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177866|UniProtKB=T1FCE0 T1FCE0 20206489 PTHR12242:SF45 OS02G0130600 PROTEIN-RELATED MARVEL DOMAIN-CONTAINING PROTEIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG160282|UniProtKB=T1EQ17 T1EQ17 20198667 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG151221|UniProtKB=T1EKJ0 T1EKJ0 20197090 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG99472|UniProtKB=T1G9S9 T1G9S9 20217825 PTHR13931:SF2 UBIQUITINATION FACTOR E4 UBIQUITIN CONJUGATION FACTOR E4 B transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule modification#GO:0043412;protein catabolic process#GO:0030163;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;protein ubiquitination#GO:0016567;macromolecule catabolic process#GO:0009057;response to endoplasmic reticulum stress#GO:0034976;protein modification by small protein conjugation or removal#GO:0070647;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;ERAD pathway#GO:0036503;response to organonitrogen compound#GO:0010243;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;cellular response to stress#GO:0033554 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG103925|UniProtKB=T1EDI6 T1EDI6 20194638 PTHR47977:SF20 RAS-RELATED PROTEIN RAB RAS-RELATED PROTEIN RAB-27A GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;anion binding#GO:0043168;ion binding#GO:0043167 positive regulation of secretion#GO:0051047;transport#GO:0006810;positive regulation of transport#GO:0051050;regulation of secretion by cell#GO:1903530;vesicle-mediated transport#GO:0016192;regulation of localization#GO:0032879;cellular process#GO:0009987;regulation of vesicle-mediated transport#GO:0060627;positive regulation of cellular process#GO:0048522;localization#GO:0051179;regulation of biological process#GO:0050789;regulation of transport#GO:0051049;exocytosis#GO:0006887;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;regulation of secretion#GO:0051046;secretion#GO:0046903;biological regulation#GO:0065007;positive regulation of secretion by cell#GO:1903532;positive regulation of biological process#GO:0048518;export from cell#GO:0140352;regulation of exocytosis#GO:0017157;secretion by cell#GO:0032940 intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;secretory granule#GO:0030141;Golgi apparatus#GO:0005794;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;apical part of cell#GO:0045177;intracellular anatomical structure#GO:0005622;apical plasma membrane#GO:0016324;cytoplasm#GO:0005737;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;plasma membrane region#GO:0098590;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;secretory vesicle#GO:0099503;plasma membrane#GO:0005886 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG158767|UniProtKB=T1EN86 T1EN86 20198036 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166510|UniProtKB=T1EY70 T1EY70 20201520 PTHR10562:SF14 SMALL UBIQUITIN-RELATED MODIFIER SMALL UBIQUITIN-RELATED MODIFIER 1 enzyme binding#GO:0019899;protein binding#GO:0005515;binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein sumoylation#GO:0016925;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 p53 pathway#P00059>Sumo-1 ligase#P04635 HELRO|EnsemblGenome=HelroG157969|UniProtKB=T1EMI3 T1EMI3 20197783 PTHR12702:SF0 SEC15 EXOCYST COMPLEX COMPONENT 6 localization#GO:0051179;localization within membrane#GO:0051668;cellular localization#GO:0051641;vesicle-mediated transport to the plasma membrane#GO:0098876;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;post-Golgi vesicle-mediated transport#GO:0006892;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;Golgi to plasma membrane transport#GO:0006893;export from cell#GO:0140352;secretion by cell#GO:0032940 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;vesicle tethering complex#GO:0099023;exocyst#GO:0000145;cell cortex#GO:0005938;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG114528|UniProtKB=T1EG24 T1EG24 20195526 PTHR18860:SF159 14-3-3 PROTEIN 14-3-3 PROTEIN ZETA localization#GO:0051179;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular localization#GO:0051641;cellular response to stimulus#GO:0051716;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052;protein localization#GO:0008104 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 Parkinson disease#P00049>14-3-3#P01238;FGF signaling pathway#P00021>14-3-3#P00624;EGF receptor signaling pathway#P00018>14-3-3#P00539;PI3 kinase pathway#P00048>14-3-3#P01206 HELRO|EnsemblGenome=HelroG194357|UniProtKB=T1FVZ3 T1FVZ3 20212989 PTHR45816:SF4 MIR DOMAIN-CONTAINING PROTEIN RYR_IP3R HOMOLOGY ASSOCIATED DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG144657|UniProtKB=T1EJF5 T1EJF5 20196705 PTHR48112:SF32 HIGH MOBILITY GROUP PROTEIN DSP1 HIGH MOBILITY GROUP PROTEIN B3 HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG185027|UniProtKB=T1FMA9 T1FMA9 20209958 PTHR42908:SF10 TRANSLATION ELONGATION FACTOR-RELATED EUKARYOTIC TRANSLATION ELONGATION FACTOR 2 GTPase activity#GO:0003924;nucleic acid binding#GO:0003676;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;translation regulator activity#GO:0045182;organic cyclic compound binding#GO:0097159;ribonucleoprotein complex binding#GO:0043021;hydrolase activity#GO:0016787;ribosome binding#GO:0043022;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;protein-containing complex binding#GO:0044877;translation regulator activity, nucleic acid binding#GO:0090079;translation elongation factor activity#GO:0003746;translation factor activity, RNA binding#GO:0008135 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;translational elongation#GO:0006414;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 translation elongation factor#PC00222 HELRO|EnsemblGenome=HelroG193760|UniProtKB=T1FVB9 T1FVB9 20212765 PTHR24241:SF76 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR NEUROPEPTIDE SIFAMIDE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;binding#GO:0005488;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888;amide binding#GO:0033218 response to organic substance#GO:0010033;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;response to hormone#GO:0009725;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG169273|UniProtKB=T1F1P4 T1F1P4 20202744 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG193569|UniProtKB=T1FV49 T1FV49 20212695 PTHR15885:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 174 COILED-COIL DOMAIN-CONTAINING PROTEIN 174 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG170295|UniProtKB=T1F2W2 T1F2W2 20203161 PTHR12428:SF65 OXA1 CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to membrane#GO:0090150;localization within membrane#GO:0051668;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;membrane organization#GO:0061024;protein localization to membrane#GO:0072657;cellular component organization#GO:0016043;cellular process#GO:0009987;protein insertion into membrane#GO:0051205;establishment of protein localization#GO:0045184;protein localization#GO:0008104 transporter#PC00227 HELRO|EnsemblGenome=HelroG180384|UniProtKB=T1FFV2 T1FFV2 20207701 PTHR46601:SF1 ULP_PROTEASE DOMAIN-CONTAINING PROTEIN ADF-H DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168011|UniProtKB=T1F023 T1F023 20202173 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193868|UniProtKB=T1FVF5 T1FVF5 20212801 PTHR46189:SF1 LD41958P LD41958P cytoplasm#GO:0005737;endosome#GO:0005768;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185095|UniProtKB=T1FME1 T1FME1 20209990 PTHR12695:SF2 GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2 GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;nucleotide-excision repair#GO:0006289;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;regulation of DNA-templated transcription#GO:0006355;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;primary metabolic process#GO:0044238;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;regulation of cellular biosynthetic process#GO:0031326;response to stress#GO:0006950;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;cellular response to stress#GO:0033554;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;DNA-directed RNA polymerase complex#GO:0000428;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nucleoplasm#GO:0005654;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;serine/threonine protein kinase complex#GO:1902554;RNA polymerase II transcription regulator complex#GO:0090575;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;transcription regulator complex#GO:0005667;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;transcription factor TFIIH holo complex#GO:0005675;nuclear protein-containing complex#GO:0140513 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG105471|UniProtKB=T1EDV2 T1EDV2 20194754 PTHR48078:SF2 THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED CATABOLIC L-SERINE_THREONINE DEHYDRATASE lyase activity#GO:0016829;catalytic activity#GO:0003824 branched-chain amino acid metabolic process#GO:0009081;organonitrogen compound catabolic process#GO:1901565;biosynthetic process#GO:0009058;branched-chain amino acid biosynthetic process#GO:0009082;carboxylic acid biosynthetic process#GO:0046394;amino acid catabolic process#GO:0009063;nitrogen compound metabolic process#GO:0006807;alpha-amino acid metabolic process#GO:1901605;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;L-amino acid metabolic process#GO:0170033;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248;organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;alpha-amino acid biosynthetic process#GO:1901607;aspartate family amino acid metabolic process#GO:0009066;small molecule biosynthetic process#GO:0044283;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG83112|UniProtKB=T1G504 T1G504 20216152 PTHR10352:SF25 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G FOUND IN NEURONS, ISOFORM A-RELATED translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG108224|UniProtKB=T1EEH1 T1EEH1 20194973 PTHR47330:SF1 POLY(U)-BINDING-SPLICING FACTOR PUF60-B-RELATED POLY(U)-BINDING-SPLICING FACTOR PUF60 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;regulation of nitrogen compound metabolic process#GO:0051171;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;alternative mRNA splicing, via spliceosome#GO:0000380;regulation of mRNA processing#GO:0050684;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;mRNA splice site recognition#GO:0006376;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;regulation of RNA splicing#GO:0043484;nucleic acid metabolic process#GO:0090304;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;biological regulation#GO:0065007;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375;spliceosomal complex assembly#GO:0000245;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;regulation of metabolic process#GO:0019222;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323 ribonucleoprotein complex#GO:1990904;catalytic step 2 spliceosome#GO:0071013;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;precatalytic spliceosome#GO:0071011;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG75833|UniProtKB=T1G2A9 T1G2A9 20215207 PTHR45134:SF22 OS08G0543275 PROTEIN G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG70909|UniProtKB=T1G0E2 T1G0E2 20214540 PTHR43943:SF2 DEHYDROGENASE/REDUCTASE (SDR FAMILY) MEMBER 4 DEHYDROGENASE_REDUCTASE 4 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG169717|UniProtKB=T1F297 T1F297 20202947 PTHR48125:SF12 LP07818P1 AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED Huntington disease#P00029>N-Wasp#P00769;Cytoskeletal regulation by Rho GTPase#P00016>N-WASP#P00525 HELRO|EnsemblGenome=HelroG184596|UniProtKB=T1FLJ7 T1FLJ7 20209696 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182878|UniProtKB=T1FIW4 T1FIW4 20208763 PTHR34740:SF5 FINGER, C3HC4 TYPE, PUTATIVE-RELATED-RELATED POLYMERASE NUCLEOTIDYL TRANSFERASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG111152|UniProtKB=T1EF88 T1EF88 20195240 PTHR16216:SF2 DYNEIN ASSEMBLY FACTOR 5, AXONEMAL DYNEIN AXONEMAL ASSEMBLY FACTOR 5 chaperone#PC00072 HELRO|EnsemblGenome=HelroG193306|UniProtKB=T1FUV2 T1FUV2 20212598 PTHR16091:SF1 TTC17 PROTEIN TETRATRICOPEPTIDE REPEAT PROTEIN 17 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-containing complex assembly#GO:0065003;actin polymerization or depolymerization#GO:0008154;actin filament polymerization#GO:0030041;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;protein polymerization#GO:0051258;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG167717|UniProtKB=T1EZQ1 T1EZQ1 20202051 PTHR14167:SF116 SH3 DOMAIN-CONTAINING CAP, ISOFORM AC scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185949|UniProtKB=T1FNH1 T1FNH1 20210368 PTHR12974:SF36 PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN 44 POLYNUCLEOTIDE ADENYLYLTRANSFERASE adenylyltransferase activity#GO:0070566;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;transferase activity#GO:0016740;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772 positive regulation of gene expression#GO:0010628;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of mRNA stability#GO:0043488;regulation of catabolic process#GO:0009894;regulation of mRNA catabolic process#GO:0061013;negative regulation of RNA metabolic process#GO:0051253;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;regulation of biosynthetic process#GO:0009889;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;mRNA stabilization#GO:0048255;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;RNA stabilization#GO:0043489;negative regulation of cellular catabolic process#GO:0031330;negative regulation of metabolic process#GO:0009892;positive regulation of cellular biosynthetic process#GO:0031328;regulation of RNA stability#GO:0043487;regulation of cellular catabolic process#GO:0031329;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;negative regulation of catabolic process#GO:0009895;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of RNA catabolic process#GO:1902369;regulation of metabolic process#GO:0019222;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323 HELRO|EnsemblGenome=HelroG76513|UniProtKB=T1G2K8 T1G2K8 20215306 PTHR13113:SF1 ECSIT EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAYS EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAY, MITOCHONDRIAL response to external biotic stimulus#GO:0043207;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;immune response#GO:0006955;cell communication#GO:0007154;cellular process#GO:0009987;defense response to symbiont#GO:0140546;regulation of biological process#GO:0050789;immune system process#GO:0002376;response to stimulus#GO:0050896;response to external stimulus#GO:0009605;enzyme-linked receptor protein signaling pathway#GO:0007167;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to other organism#GO:0098542;regulation of cellular process#GO:0050794;response to other organism#GO:0051707;cell surface receptor signaling pathway#GO:0007166;transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0007178;biological process involved in interspecies interaction between organisms#GO:0044419;biological regulation#GO:0065007;innate immune response#GO:0045087;defense response#GO:0006952;signaling#GO:0023052 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 Toll receptor signaling pathway#P00054>ECSIT#P01349 HELRO|EnsemblGenome=HelroG169290|UniProtKB=T1F1Q8 T1F1Q8 20202758 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG91624|UniProtKB=T1G865 T1G865 20217262 PTHR47023:SF1 SEX PEPTIDE RECEPTOR SEX PEPTIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG194010|UniProtKB=T1FVK4 T1FVK4 20212850 PTHR45080:SF33 CONTACTIN 5 IG-LIKE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cellular component organization or biogenesis#GO:0071840;synapse organization#GO:0050808;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156;cell junction organization#GO:0034330;cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cellular process#GO:0009987 somatodendritic compartment#GO:0036477;cell body#GO:0044297;neuron projection#GO:0043005;neuronal cell body#GO:0043025;cell projection#GO:0042995;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;plasma membrane#GO:0005886;axon#GO:0030424 HELRO|EnsemblGenome=HelroG190366|UniProtKB=T1FRX6 T1FRX6 20211573 PTHR34491:SF104 A-TYPE INCLUSION PROTEIN, PUTATIVE-RELATED UBIQUITINATION NETWORK SIGNALING PROTEIN ACRB HELRO|EnsemblGenome=HelroG193980|UniProtKB=T1FVJ2 T1FVJ2 20212838 PTHR43580:SF2 OXIDOREDUCTASE GLYR1-RELATED CYTOKINE-LIKE NUCLEAR FACTOR N-PAC oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG192356|UniProtKB=T1FTU9 T1FTU9 20212246 PTHR13167:SF25 PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215 response to external stimulus#GO:0009605;response to stimulus#GO:0050896;detection of mechanical stimulus#GO:0050982;cellular response to stimulus#GO:0051716;response to mechanical stimulus#GO:0009612;regulation of biological quality#GO:0065008;regulation of membrane potential#GO:0042391;biological regulation#GO:0065007;cellular response to external stimulus#GO:0071496;detection of stimulus#GO:0051606;response to abiotic stimulus#GO:0009628;cellular process#GO:0009987 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG102534|UniProtKB=T1EDA1 T1EDA1 20194553 PTHR45998:SF2 SERINE/THREONINE-PROTEIN KINASE 16 SERINE_THREONINE-PROTEIN KINASE 16 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG80369|UniProtKB=T1G3Z8 T1G3Z8 20215796 PTHR45706:SF4 TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG85090|UniProtKB=T1G5S6 T1G5S6 20216423 PTHR11451:SF46 THREONINE-TRNA LIGASE THREONINE--TRNA LIGASE catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG175486|UniProtKB=T1F9B2 T1F9B2 20205411 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG85834|UniProtKB=T1G631 T1G631 20216528 PTHR31449:SF3 UPF0598 PROTEIN C8ORF82 UPF0598 PROTEIN C8ORF82 HELRO|EnsemblGenome=HelroG134347|UniProtKB=T1EI45 T1EI45 20196245 PTHR13464:SF0 TRANSCRIPTIONAL REGULATOR PROTEIN HCNGP SAP30-BINDING PROTEIN membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG63800|UniProtKB=T1FXK5 T1FXK5 20213553 PTHR24393:SF136 ZINC FINGER PROTEIN LD28458P-RELATED DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG105985|UniProtKB=T1EDZ0 T1EDZ0 20194792 PTHR12644:SF0 ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 5 cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;Arp2/3 complex-mediated actin nucleation#GO:0034314;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;Arp2/3 protein complex#GO:0005885;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Integrin signalling pathway#P00034>Arp2/3#P00912;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Arp2/3#P00876;Cytoskeletal regulation by Rho GTPase#P00016>ARP2/3#P00511 HELRO|EnsemblGenome=HelroG175376|UniProtKB=T1F976 T1F976 20205375 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176607|UniProtKB=T1FAQ2 T1FAQ2 20205901 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED FMRFAMIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG173545|UniProtKB=T1F6Y8 T1F6Y8 20204587 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG182184|UniProtKB=T1FHW2 T1FHW2 20208411 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG85518|UniProtKB=T1G5Y4 T1G5Y4 20216481 PTHR23359:SF234 NUCLEOTIDE KINASE ADENYLATE KINASE 2, MITOCHONDRIAL transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, phosphate group as acceptor#GO:0016776;catalytic activity#GO:0003824;kinase activity#GO:0016301 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 nucleotide kinase#PC00172;kinase#PC00137 De novo purine biosynthesis#P02738>Adenylate kinase#P02896 HELRO|EnsemblGenome=HelroG171378|UniProtKB=T1F474 T1F474 20203623 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG153250|UniProtKB=T1EL16 T1EL16 20197266 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG113955|UniProtKB=T1EFX6 T1EFX6 20195478 PTHR11792:SF17 ARRESTIN KURTZ ARRESTIN protein binding#GO:0005515;G protein-coupled receptor binding#GO:0001664;binding#GO:0005488;signaling receptor binding#GO:0005102 regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;negative regulation of response to stimulus#GO:0048585;receptor internalization#GO:0031623;negative regulation of signaling#GO:0023057;transport#GO:0006810;endocytosis#GO:0006897;regulation of signaling#GO:0023051;vesicle-mediated transport#GO:0016192;regulation of G protein-coupled receptor signaling pathway#GO:0008277;cellular process#GO:0009987;localization#GO:0051179;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;receptor-mediated endocytosis#GO:0006898;negative regulation of cell communication#GO:0010648;negative regulation of cellular process#GO:0048523;import into cell#GO:0098657 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 Wnt signaling pathway#P00057>beta-arrestin#P01456;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>beta-arrestin#P00880;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>beta-arrestin#P00723 HELRO|EnsemblGenome=HelroG87779|UniProtKB=T1G6V3 T1G6V3 20216800 PTHR11955:SF157 FATTY ACID BINDING PROTEIN LIPOCALIN_CYTOSOLIC FATTY-ACID BINDING DOMAIN-CONTAINING PROTEIN fatty acid binding#GO:0005504;small molecule binding#GO:0036094;binding#GO:0005488;carboxylic acid binding#GO:0031406;lipid binding#GO:0008289;ion binding#GO:0043167;organic acid binding#GO:0043177;anion binding#GO:0043168 localization#GO:0051179;monocarboxylic acid transport#GO:0015718;organic substance transport#GO:0071702;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;organic anion transport#GO:0015711;fatty acid transport#GO:0015908;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;lipid localization#GO:0010876;lipid transport#GO:0006869 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG188210|UniProtKB=T1FPS2 T1FPS2 20210819 PTHR11304:SF29 EPHRIN EPHRIN protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 neuron projection guidance#GO:0097485;signal transduction#GO:0007165;neurogenesis#GO:0022008;cell projection organization#GO:0030030;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;regulation of biological process#GO:0050789;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;axonogenesis#GO:0007409;plasma membrane bounded cell projection morphogenesis#GO:0120039;signaling#GO:0023052;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;multicellular organism development#GO:0007275;cell morphogenesis#GO:0000902;cellular component organization#GO:0016043;cell communication#GO:0007154;cellular process#GO:0009987;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;neuron projection development#GO:0031175;axon development#GO:0061564;enzyme-linked receptor protein signaling pathway#GO:0007167;cell morphogenesis involved in neuron differentiation#GO:0048667;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 membrane-bound signaling molecule#PC00152;intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG68065|UniProtKB=T1FZ98 T1FZ98 20214146 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG193527|UniProtKB=T1FV31 T1FV31 20212677 PTHR15549:SF6 PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR MID2 DOMAIN-CONTAINING PROTEIN immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG159565|UniProtKB=T1EP62 T1EP62 20198362 PTHR15231:SF1 PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG175568|UniProtKB=T1F9D9 T1F9D9 20205438 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193726|UniProtKB=T1FVA6 T1FVA6 20212752 PTHR19303:SF75 TRANSPOSON HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG105504|UniProtKB=T1EDW0 T1EDW0 20194762 PTHR45775:SF6 RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C HELRO|EnsemblGenome=HelroG67713|UniProtKB=T1FZ44 T1FZ44 20214092 PTHR10681:SF163 THIOREDOXIN PEROXIDASE AT16346P-RELATED oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;antioxidant activity#GO:0016209;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;response to stress#GO:0006950;catabolic process#GO:0009056;cellular metabolic process#GO:0044237;homeostatic process#GO:0042592;response to oxidative stress#GO:0006979;cellular process#GO:0009987;cellular response to stress#GO:0033554;cellular homeostasis#GO:0019725;cellular catabolic process#GO:0044248;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 peroxidase#PC00180;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG95199|UniProtKB=T1G950 T1G950 20217597 PTHR11871:SF0 PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B PROTEIN PHOSPHATASE PP2A 55 KDA REGULATORY SUBUNIT phosphatase regulator activity#GO:0019208;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888;enzyme regulator activity#GO:0030234 protein serine/threonine phosphatase complex#GO:0008287;cytoplasm#GO:0005737;cytosol#GO:0005829;protein-containing complex#GO:0032991;cellular anatomical entity#GO:0110165;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 FGF signaling pathway#P00021>PP2A#P00629 HELRO|EnsemblGenome=HelroG164388|UniProtKB=T1EVD1 T1EVD1 20200531 PTHR11927:SF9 GALACTOSIDE 2-L-FUCOSYLTRANSFERASE L-FUCOSYLTRANSFERASE transferase activity#GO:0016740;fucosyltransferase activity#GO:0008417;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein glycosylation#GO:0006486;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycosylation#GO:0070085;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG185754|UniProtKB=T1FN90 T1FN90 20210288 PTHR24068:SF147 UBIQUITIN-CONJUGATING ENZYME E2 E2 UBIQUITIN-CONJUGATING ENZYME ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E3#P01490;Ubiquitin proteasome pathway#P00060>E2#P01491 HELRO|EnsemblGenome=HelroG154673|UniProtKB=T1ELF5 T1ELF5 20197405 PTHR11142:SF4 PSEUDOURIDYLATE SYNTHASE PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG isomerase activity#GO:0016853;intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;mRNA modification#GO:0016556;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;pseudouridine synthesis#GO:0001522;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 lyase#PC00144 HELRO|EnsemblGenome=HelroG186113|UniProtKB=T1FNN8 T1FNN8 20210435 PTHR11117:SF2 SUCCINYL-COA LIGASE SUBUNIT ALPHA SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL ligase activity#GO:0016874;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 aerobic respiration#GO:0009060;cellular respiration#GO:0045333;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;cellular process#GO:0009987;tricarboxylic acid cycle#GO:0006099;energy derivation by oxidation of organic compounds#GO:0015980;primary metabolic process#GO:0044238;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 TCA cycle#P00051>Succinyl CoA Synthetase#P01274 HELRO|EnsemblGenome=HelroG176266|UniProtKB=T1FAC5 T1FAC5 20205774 PTHR22588:SF3 VWFA DOMAIN-CONTAINING PROTEIN VWFA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG81815|UniProtKB=T1G4J0 T1G4J0 20215988 PTHR15362:SF4 PHOSPHATIDYLINOSITOL SYNTHASE CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG67130|UniProtKB=T1FYW9 T1FYW9 20214017 PTHR10032:SF271 ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS RH12261P-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG131581|UniProtKB=T1EHW1 T1EHW1 20196161 PTHR24058:SF112 DUAL SPECIFICITY PROTEIN KINASE DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 3 HOMOLOG-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;peptidyl-threonine phosphorylation#GO:0018107;nitrogen compound metabolic process#GO:0006807;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG65543|UniProtKB=T1FY92 T1FY92 20213790 PTHR10257:SF3 SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM protein phosphatase#PC00195;protein modifying enzyme#PC00260 Wnt signaling pathway#P00057>PP2A#P01438;FGF signaling pathway#P00021>PP2A#P00629;EGF receptor signaling pathway#P00018>PP2A#P00547 HELRO|EnsemblGenome=HelroG192188|UniProtKB=T1FTN8 T1FTN8 20212185 PTHR16011:SF0 IFT57/HIPPI INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG non-motile cilium assembly#GO:1905515;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;cilium assembly#GO:0060271;cell projection organization#GO:0030030;transport#GO:0006810;microtubule-based movement#GO:0007018;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;transport along microtubule#GO:0010970;cell projection assembly#GO:0030031;intraciliary transport#GO:0042073;localization#GO:0051179;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based transport#GO:0099111;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;organelle organization#GO:0006996;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;plasma membrane bounded cell projection assembly#GO:0120031;protein-containing complex localization#GO:0031503 microtubule organizing center#GO:0005815;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;intraciliary transport particle B#GO:0030992;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929;intraciliary transport particle#GO:0030990 structural protein#PC00211 Huntington disease#P00029>Hip-12#P00763;Huntington disease#P00029>Hippi#P00794 HELRO|EnsemblGenome=HelroG194899|UniProtKB=T1FWJ5 T1FWJ5 20213190 PTHR24135:SF28 SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN LD13733P scaffold/adaptor protein#PC00226 Ionotropic glutamate receptor pathway#P00037>PSD95#P00999 HELRO|EnsemblGenome=HelroG185203|UniProtKB=T1FMI1 T1FMI1 20210030 PTHR46568:SF1 ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL HELRO|EnsemblGenome=HelroG106435|UniProtKB=T1EE26 T1EE26 20194828 PTHR24031:SF307 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX1 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG114815|UniProtKB=T1EG46 T1EG46 20195548 PTHR12430:SF0 MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20 TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20 signal sequence binding#GO:0005048;protein transmembrane transporter activity#GO:0008320;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;binding#GO:0005488;amide binding#GO:0033218;peptide binding#GO:0042277 cellular localization#GO:0051641;transmembrane transport#GO:0055085;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;transport#GO:0006810;protein transmembrane transport#GO:0071806;protein targeting#GO:0006605;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;protein localization to mitochondrion#GO:0070585;cellular process#GO:0009987;protein transmembrane import into intracellular organelle#GO:0044743;establishment of protein localization#GO:0045184;RNA localization#GO:0006403;protein localization#GO:0008104;localization#GO:0051179;mitochondrial transport#GO:0006839;organic substance transport#GO:0071702;protein import into mitochondrial matrix#GO:0030150;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein targeting to mitochondrion#GO:0006626;establishment of protein localization to mitochondrion#GO:0072655;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;protein transport#GO:0015031;protein localization to organelle#GO:0033365;mitochondrial transmembrane transport#GO:1990542 envelope#GO:0031975;bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane#GO:0005741;mitochondrial outer membrane translocase complex#GO:0005742;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867;mitochondrial protein-containing complex#GO:0098798 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG63126|UniProtKB=T1FXB4 T1FXB4 20213462 PTHR11071:SF561 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;catalytic activity#GO:0003824;peptide binding#GO:0042277;amide binding#GO:0033218 macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein peptidyl-prolyl isomerization#GO:0000413;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG113786|UniProtKB=T1EFW4 T1EFW4 20195466 PTHR11309:SF148 FRIZZLED SECRETED FRIZZLED-RELATED PROTEIN 1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;protein binding#GO:0005515;Wnt-protein binding#GO:0017147;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;non-canonical Wnt signaling pathway#GO:0035567;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;cell-cell signaling by wnt#GO:0198738;canonical Wnt signaling pathway#GO:0060070;cell-cell signaling#GO:0007267;signaling#GO:0023052;Wnt signaling pathway#GO:0016055 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;extracellular space#GO:0005615;membrane#GO:0016020;extracellular region#GO:0005576;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG75099|UniProtKB=T1G206 T1G206 20215104 PTHR31655:SF7 PROTEIN FAM78A PROTEIN FAM78A HELRO|EnsemblGenome=HelroG185670|UniProtKB=T1FN44 T1FN44 20210242 PTHR19965:SF82 RNA AND EXPORT FACTOR BINDING PROTEIN THO COMPLEX SUBUNIT 4 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;mRNA transport#GO:0051028;RNA localization#GO:0006403;localization#GO:0051179;organic substance transport#GO:0071702;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG146952|UniProtKB=T1EJV8 T1EJV8 20196858 PTHR23310:SF77 ACYL-COA-BINDING PROTEIN, ACBP LD25952P carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;amide binding#GO:0033218;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;lipid binding#GO:0008289;anion binding#GO:0043168;ion binding#GO:0043167 lipid metabolic process#GO:0006629;oxoacid metabolic process#GO:0043436;fatty acid metabolic process#GO:0006631;cellular metabolic process#GO:0044237;cellular process#GO:0009987;cellular lipid metabolic process#GO:0044255;organic acid metabolic process#GO:0006082;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG170189|UniProtKB=T1F2R9 T1F2R9 20203118 PTHR24250:SF67 CHYMOTRYPSIN-RELATED PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG184778|UniProtKB=T1FLZ1 T1FLZ1 20209840 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG72024|UniProtKB=T1G0U2 T1G0U2 20214690 PTHR10468:SF0 PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1/ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE acetylglucosaminyltransferase activity#GO:0008375;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG162688|UniProtKB=T1ET05 T1ET05 20199705 PTHR24126:SF14 ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED ANK_REP_REGION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG95414|UniProtKB=T1G956 T1G956 20217603 PTHR10459:SF112 DNA LIGASE POLY [ADP-RIBOSE] POLYMERASE 1 transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;pentosyltransferase activity#GO:0016763;catalytic activity#GO:0003824 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;double-strand break repair#GO:0006302;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;post-translational protein modification#GO:0043687;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;response to stress#GO:0006950;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;metabolic process#GO:0008152 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 FAS signaling pathway#P00020>PARP#P00600 HELRO|EnsemblGenome=HelroG88632|UniProtKB=T1G746 T1G746 20216893 PTHR43798:SF5 MONOACYLGLYCEROL LIPASE MONOACYLGLYCEROL LIPASE ABHD6 hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;neutral lipid catabolic process#GO:0046461;cellular metabolic process#GO:0044237;glycerolipid catabolic process#GO:0046503;lipid catabolic process#GO:0016042;cellular process#GO:0009987;acylglycerol metabolic process#GO:0006639;primary metabolic process#GO:0044238;acylglycerol catabolic process#GO:0046464;neutral lipid metabolic process#GO:0006638;glycerolipid metabolic process#GO:0046486;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248 cellular anatomical entity#GO:0110165;membrane#GO:0016020 lipase#PC00143 HELRO|EnsemblGenome=HelroG185141|UniProtKB=T1FMG1 T1FMG1 20210010 PTHR22734:SF3 U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4 RIBOSOME PRODUCTION FACTOR 1 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of 5.8S rRNA#GO:0000460;maturation of LSU-rRNA#GO:0000470;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;preribosome, large subunit precursor#GO:0030687;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG66984|UniProtKB=T1FYU7 T1FYU7 20213995 PTHR43195:SF1 TRANSKETOLASE FI06132P-RELATED cation binding#GO:0043169;transferase activity#GO:0016740;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168 metabolite interconversion enzyme#PC00262;transketolase#PC00221 HELRO|EnsemblGenome=HelroG83483|UniProtKB=T1G561 T1G561 20216209 PTHR23050:SF523 CALCIUM BINDING PROTEIN CALMODULIN cation binding#GO:0043169;small molecule binding#GO:0036094;molecular function regulator activity#GO:0098772;binding#GO:0005488;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;enzyme regulator activity#GO:0030234 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061 B cell activation#P00010>Calmodulin#P00375;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Calmodulin#P00755;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716;T cell activation#P00053>Calmodulin#P01305 HELRO|EnsemblGenome=HelroG69873|UniProtKB=T1FZZ2 T1FZZ2 20214390 PTHR43073:SF2 DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)] DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)] dehydrogenase#PC00092;oxidoreductase#PC00176 Pyrimidine Metabolism#P02771>Dihydrouracil Dehydrogenase#P03128 HELRO|EnsemblGenome=HelroG165713|UniProtKB=T1EX73 T1EX73 20201173 PTHR46680:SF3 NF-KAPPA-B INHIBITOR ALPHA NF-KAPPA-B INHIBITOR CACTUS Toll pathway-drosophila#P06217>CACT#P06342 HELRO|EnsemblGenome=HelroG177906|UniProtKB=T1FCG3 T1FCG3 20206512 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG174791|UniProtKB=T1F8H2 T1F8H2 20205121 PTHR36168:SF1 CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77755|UniProtKB=T1G335 T1G335 20215483 PTHR21255:SF7 T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN DYNEIN LIGHT CHAIN TCTEX-TYPE PROTEIN 2B protein binding#GO:0005515;binding#GO:0005488 microtubule-based movement#GO:0007018;cellular process#GO:0009987;microtubule-based process#GO:0007017 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;microtubule cytoskeleton#GO:0015630;dynein complex#GO:0030286;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic dynein complex#GO:0005868;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG87327|UniProtKB=T1G6P1 T1G6P1 20216738 PTHR13318:SF193 PARTNER OF PAIRED, ISOFORM B-RELATED F-BOX_LRR-REPEAT PROTEIN 16 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234 HELRO|EnsemblGenome=HelroG180094|UniProtKB=T1FFG6 T1FFG6 20207565 PTHR36191:SF10 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG155690|UniProtKB=T1ELK5 T1ELK5 20197455 PTHR10840:SF0 PROGRAMMED CELL DEATH PROTEIN 5 PROGRAMMED CELL DEATH PROTEIN 5 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG185082|UniProtKB=T1FMD5 T1FMD5 20209984 PTHR11669:SF20 REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT REPLICATION FACTOR C SUBUNIT 4 ATP-dependent activity, acting on DNA#GO:0008094;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on DNA#GO:0140097;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;response to stress#GO:0006950;nitrogen compound metabolic process#GO:0006807;DNA-templated DNA replication#GO:0006261;DNA replication#GO:0006260;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;replication fork#GO:0005657 DNA-directed DNA polymerase#PC00018 DNA replication#P00017>RFC#P00529 HELRO|EnsemblGenome=HelroG69675|UniProtKB=T1FZX9 T1FZX9 20214377 PTHR13023:SF3 APYRASE SOLUBLE CALCIUM-ACTIVATED NUCLEOTIDASE 1 pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;nucleoside diphosphate phosphatase activity#GO:0017110;catalytic activity#GO:0003824 glycoprotein biosynthetic process#GO:0009101;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;proteoglycan metabolic process#GO:0006029;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;proteoglycan biosynthetic process#GO:0030166;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 nucleotide phosphatase#PC00173;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG71154|UniProtKB=T1G0H1 T1G0H1 20214569 PTHR46276:SF1 E3 UBIQUITIN-PROTEIN LIGASE UBR5 E3 UBIQUITIN-PROTEIN LIGASE UBR5 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 regulation of cell communication#GO:0010646;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;positive regulation of signal transduction#GO:0009967;regulation of signaling#GO:0023051;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;positive regulation of Wnt signaling pathway#GO:0030177;post-translational protein modification#GO:0043687;regulation of canonical Wnt signaling pathway#GO:0060828;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;positive regulation of canonical Wnt signaling pathway#GO:0090263;positive regulation of response to stimulus#GO:0048584;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;regulation of Wnt signaling pathway#GO:0030111;regulation of signal transduction#GO:0009966;positive regulation of cell communication#GO:0010647;biological regulation#GO:0065007;protein polyubiquitination#GO:0000209;positive regulation of signaling#GO:0023056;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;positive regulation of biological process#GO:0048518;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Hedgehog signaling pathway#P00025>Ubiquitin ligase#P00693 HELRO|EnsemblGenome=HelroG156323|UniProtKB=T1ELT8 T1ELT8 20197538 PTHR10953:SF4 UBIQUITIN-ACTIVATING ENZYME E1 UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN ligase activity#GO:0016874;transferase activity#GO:0016740;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877;nucleotidyltransferase activity#GO:0016779;thiosulfate sulfurtransferase activity#GO:0004792;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity, acting on a protein#GO:0140096;sulfurtransferase activity#GO:0016783 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;cellular process#GO:0009987;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;response to stimulus#GO:0050896;DNA damage response#GO:0006974;response to stress#GO:0006950;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E1#P01492 HELRO|EnsemblGenome=HelroG70549|UniProtKB=T1G080 T1G080 20214478 PTHR12978:SF0 HISTIDINE TRIAD HIT PROTEIN MEMBER M7GPPPX DIPHOSPHATASE RNA binding#GO:0003723;nucleic acid binding#GO:0003676;RNA cap binding#GO:0000339;binding#GO:0005488;organic cyclic compound binding#GO:0097159 negative regulation of gene expression#GO:0010629;regulation of catabolic process#GO:0009894;heterocycle catabolic process#GO:0046700;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;nucleobase-containing compound metabolic process#GO:0006139;RNA destabilization#GO:0050779;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;regulation of biological quality#GO:0065008;nitrogen compound metabolic process#GO:0006807;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;positive regulation of mRNA catabolic process#GO:0061014;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of catabolic process#GO:0009896;mRNA destabilization#GO:0061157;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323;positive regulation of nitrogen compound metabolic process#GO:0051173;cellular aromatic compound metabolic process#GO:0006725;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;RNA metabolic process#GO:0016070;positive regulation of cellular catabolic process#GO:0031331;cellular nitrogen compound catabolic process#GO:0044270;RNA decapping#GO:0110154;organic cyclic compound metabolic process#GO:1901360;positive regulation of metabolic process#GO:0009893;mRNA catabolic process#GO:0006402;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;positive regulation of mRNA metabolic process#GO:1903313;heterocycle metabolic process#GO:0046483;negative regulation of biosynthetic process#GO:0009890;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of cellular catabolic process#GO:0031329;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;positive regulation of RNA metabolic process#GO:0051254 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;nucleus#GO:0005634;P-body#GO:0000932;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG93209|UniProtKB=T1G8U4 T1G8U4 20217491 PTHR10590:SF4 SODIUM/NUCLEOSIDE COTRANSPORTER SOLUTE CARRIER FAMILY 28 MEMBER 3 carbohydrate derivative transmembrane transporter activity#GO:1901505;secondary active transmembrane transporter activity#GO:0015291;nucleoside transmembrane transporter activity#GO:0005337;transmembrane transporter activity#GO:0022857;symporter activity#GO:0015293;nucleobase-containing compound transmembrane transporter activity#GO:0015932;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215 localization#GO:0051179;organic substance transport#GO:0071702;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;nucleobase-containing compound transport#GO:0015931;transport#GO:0006810;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG172303|UniProtKB=T1F571 T1F571 20203970 PTHR46007:SF8 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 C2H2-TYPE DOMAIN-CONTAINING PROTEIN molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;protein binding#GO:0005515;transcription factor binding#GO:0008134 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG191423|UniProtKB=T1FSZ0 T1FSZ0 20211937 PTHR13377:SF3 PLACENTAL PROTEIN 6 TRANSMEMBRANE PROTEIN 115 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;Golgi vesicle transport#GO:0048193;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;transport#GO:0006810 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG69097|UniProtKB=T1FZP6 T1FZP6 20214294 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG123852|UniProtKB=T1EGZ3 T1EGZ3 20195843 PTHR24193:SF121 ANKYRIN REPEAT PROTEIN ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D HELRO|EnsemblGenome=HelroG141556|UniProtKB=T1EJ36 T1EJ36 20196586 PTHR19297:SF181 GLYCOSYLTRANSFERASE 14 FAMILY MEMBER PROTEIN XYLOSYLTRANSFERASE acetylglucosaminyltransferase activity#GO:0008375;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG167309|UniProtKB=T1EZ88 T1EZ88 20201888 PTHR11337:SF8 MUCIN/PORIMIN VISGUN, ISOFORM E cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG195045|UniProtKB=T1FWP6 T1FWP6 20213241 PTHR11506:SF42 LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 5 localization#GO:0051179;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;protein localization to organelle#GO:0033365;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 bounding membrane of organelle#GO:0098588;lytic vacuole membrane#GO:0098852;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vacuolar membrane#GO:0005774;late endosome membrane#GO:0031902;vacuole#GO:0005773;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endosome membrane#GO:0010008;lytic vacuole#GO:0000323;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;lysosomal membrane#GO:0005765;lysosome#GO:0005764;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG174815|UniProtKB=T1F8I3 T1F8I3 20205132 PTHR13328:SF4 NEGATIVE ELONGATION FACTOR A NELF-A NEGATIVE ELONGATION FACTOR A HELRO|EnsemblGenome=HelroG174628|UniProtKB=T1F8B3 T1F8B3 20205062 PTHR44027:SF7 DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG chaperone#PC00072 HELRO|EnsemblGenome=HelroG112468|UniProtKB=T1EFK1 T1EFK1 20195353 PTHR24270:SF61 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 apolipoprotein#PC00052 HELRO|EnsemblGenome=HelroG156866|UniProtKB=T1EM22 T1EM22 20197622 PTHR10870:SF0 CELL CYCLE CHECKPOINT PROTEIN RAD1 CELL CYCLE CHECKPOINT PROTEIN RAD1 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;signal transduction#GO:0007165;negative regulation of biological process#GO:0048519;DNA damage checkpoint signaling#GO:0000077;negative regulation of cell cycle process#GO:0010948;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;cell cycle checkpoint signaling#GO:0000075;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;signal transduction in response to DNA damage#GO:0042770;intracellular signal transduction#GO:0035556;signaling#GO:0023052;negative regulation of cellular process#GO:0048523;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;negative regulation of cell cycle#GO:0045786;macromolecule metabolic process#GO:0043170;negative regulation of cell cycle phase transition#GO:1901988;regulation of cell cycle phase transition#GO:1901987;cellular metabolic process#GO:0044237;cell communication#GO:0007154;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;regulation of cell cycle process#GO:0010564;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;DNA integrity checkpoint signaling#GO:0031570;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;condensed chromosome#GO:0000793;intracellular organelle lumen#GO:0070013;condensed nuclear chromosome#GO:0000794;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 DNA metabolism protein#PC00009;exodeoxyribonuclease#PC00098 HELRO|EnsemblGenome=HelroG108457|UniProtKB=T1EEJ1 T1EEJ1 20194993 PTHR24393:SF136 ZINC FINGER PROTEIN LD28458P-RELATED DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG176349|UniProtKB=T1FAF0 T1FAF0 20205799 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG194633|UniProtKB=T1FW91 T1FW91 20213087 PTHR22878:SF68 DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE HELRO|EnsemblGenome=HelroG178654|UniProtKB=T1FDI4 T1FDI4 20206883 PTHR11521:SF1 TROPONIN T TROPONIN T, SKELETAL MUSCLE cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;binding#GO:0005488 cellular component biogenesis#GO:0044085;muscle cell differentiation#GO:0042692;system process#GO:0003008;developmental process#GO:0032502;myofibril assembly#GO:0030239;cellular anatomical entity morphogenesis#GO:0032989;muscle structure development#GO:0061061;striated muscle cell differentiation#GO:0051146;cell differentiation#GO:0030154;actin filament-based process#GO:0030029;anatomical structure morphogenesis#GO:0009653;supramolecular fiber organization#GO:0097435;striated muscle cell development#GO:0055002;cytoskeleton organization#GO:0007010;non-membrane-bounded organelle assembly#GO:0140694;sarcomere organization#GO:0045214;cellular developmental process#GO:0048869;cellular component assembly#GO:0022607;cellular component assembly involved in morphogenesis#GO:0010927;cellular component organization#GO:0016043;actomyosin structure organization#GO:0031032;cellular process#GO:0009987;anatomical structure formation involved in morphogenesis#GO:0048646;organelle assembly#GO:0070925;cell development#GO:0048468;muscle cell development#GO:0055001;cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;anatomical structure development#GO:0048856;multicellular organismal process#GO:0032501;actin cytoskeleton organization#GO:0030036;muscle system process#GO:0003012;muscle contraction#GO:0006936 supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;organelle#GO:0043226;contractile fiber#GO:0043292;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;sarcomere#GO:0030017;cytoskeleton#GO:0005856;myofibril#GO:0030016 cytoskeletal protein#PC00085;actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG165746|UniProtKB=T1EX86 T1EX86 20201186 PTHR11145:SF8 BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN FAMILY MEMBER RE57120P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG84829|UniProtKB=T1G5P3 T1G5P3 20216390 PTHR12638:SF0 PROTEIN MAGO NASHI HOMOLOG MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG190300|UniProtKB=T1FRV7 T1FRV7 20211554 PTHR48051:SF54 FAMILY NOT NAMED LEUCINE-RICH REPEAT-CONTAINING PROTEIN cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG68124|UniProtKB=T1FZA6 T1FZA6 20214154 PTHR10218:SF212 GTP-BINDING PROTEIN ALPHA SUBUNIT G PROTEIN ALPHA S SUBUNIT GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;ribonucleoside triphosphate phosphatase activity#GO:0017111;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 response to organic substance#GO:0010033;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;response to organic cyclic compound#GO:0014070;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;cellular response to endogenous stimulus#GO:0071495;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;cellular response to organic substance#GO:0071310;response to organonitrogen compound#GO:0010243;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to nitrogen compound#GO:1901699;response to nitrogen compound#GO:1901698;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to oxygen-containing compound#GO:1901701;response to endogenous stimulus#GO:0009719;response to chemical#GO:0042221;dopamine receptor signaling pathway#GO:0007212;cellular response to organonitrogen compound#GO:0071417;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cellular response to organic cyclic compound#GO:0071407;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;side of membrane#GO:0098552;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;extrinsic component of membrane#GO:0019898 heterotrimeric G-protein#PC00117;G-protein#PC00020 5HT4 type receptor mediated signaling pathway#P04376>G-protein#P04430;Endothelin signaling pathway#P00019>Gs#P00584;Enkephalin release#P05913>G-Protein (s)#P05977;Histamine H2 receptor mediated signaling pathway#P04386>G-Protein#P04490;Beta3 adrenergic receptor signaling pathway#P04379>G-Protein#P04448;Beta1 adrenergic receptor signaling pathway#P04377>G-Protein#P04436;Beta2 adrenergic receptor signaling pathway#P04378>G-Protein#P04443;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458 HELRO|EnsemblGenome=HelroG189241|UniProtKB=T1FQU8 T1FQU8 20211195 PTHR18945:SF925 NEUROTRANSMITTER GATED ION CHANNEL DUF4706 DOMAIN-CONTAINING PROTEIN ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG190072|UniProtKB=T1FRN4 T1FRN4 20211481 PTHR13237:SF8 SOMETHING ABOUT SILENCING PROTEIN 10-RELATED SOMETHING ABOUT SILENCING PROTEIN 10 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG105536|UniProtKB=T1EDW1 T1EDW1 20194763 PTHR14191:SF28 PDZ DOMAIN CONTAINING PROTEIN GH04176P-RELATED protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 localization#GO:0051179;protein localization to plasma membrane#GO:0072659;protein localization to cell periphery#GO:1990778;localization within membrane#GO:0051668;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;cellular process#GO:0009987;protein localization#GO:0008104 plasma membrane region#GO:0098590;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;apical part of cell#GO:0045177;plasma membrane#GO:0005886;apical plasma membrane#GO:0016324 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185433|UniProtKB=T1FMT6 T1FMT6 20210135 PTHR10918:SF5 HOMER HOMER, ISOFORM E protein binding#GO:0005515;G protein-coupled receptor binding#GO:0001664;binding#GO:0005488;signaling receptor binding#GO:0005102 signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of metal ion transport#GO:0010959;regulation of localization#GO:0032879;regulation of calcium ion transport#GO:0051924;cell communication#GO:0007154;cellular process#GO:0009987;glutamate receptor signaling pathway#GO:0007215;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of transport#GO:0051049;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;regulation of monoatomic ion transport#GO:0043269;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG108742|UniProtKB=T1EEM0 T1EEM0 20195022 PTHR44279:SF2 HYDROXYSTEROID (11-BETA) DEHYDROGENASE 1-LIKE B-RELATED HYDROXYSTEROID (11-BETA) DEHYDROGENASE 1-LIKE B-RELATED oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG112734|UniProtKB=T1EFL7 T1EFL7 20195369 PTHR11817:SF3 PYRUVATE KINASE AT14039P-RELATED transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;ribonucleoside triphosphate metabolic process#GO:0009199;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative metabolic process#GO:1901135;heterocycle catabolic process#GO:0046700;organonitrogen compound catabolic process#GO:1901565;ribonucleotide catabolic process#GO:0009261;pyridine nucleotide metabolic process#GO:0019362;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;cellular nitrogen compound catabolic process#GO:0044270;purine-containing compound catabolic process#GO:0072523;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;purine nucleotide catabolic process#GO:0006195;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;purine ribonucleotide catabolic process#GO:0009154;nucleoside phosphate metabolic process#GO:0006753;carbohydrate catabolic process#GO:0016052;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;catabolic process#GO:0009056;nucleoside diphosphate metabolic process#GO:0009132;organic substance catabolic process#GO:1901575;carbohydrate metabolic process#GO:0005975;purine nucleotide metabolic process#GO:0006163;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;oxoacid metabolic process#GO:0043436;nucleoside phosphate catabolic process#GO:1901292;carbohydrate derivative catabolic process#GO:1901136;purine ribonucleoside triphosphate metabolic process#GO:0009205;generation of precursor metabolites and energy#GO:0006091;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;nucleotide catabolic process#GO:0009166;cellular nitrogen compound metabolic process#GO:0034641;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;nucleoside diphosphate catabolic process#GO:0009134;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;organophosphate catabolic process#GO:0046434;aromatic compound catabolic process#GO:0019439;glycolytic process#GO:0006096;organic cyclic compound catabolic process#GO:1901361;organophosphate metabolic process#GO:0019637;purine nucleoside triphosphate metabolic process#GO:0009144;nucleobase-containing compound catabolic process#GO:0034655;nucleotide metabolic process#GO:0009117;carboxylic acid metabolic process#GO:0019752;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 kinase#PC00137 Pyruvate metabolism#P02772>Pyruvate Kinase#P03132 HELRO|EnsemblGenome=HelroG173600|UniProtKB=T1F706 T1F706 20204605 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG95902|UniProtKB=T1G987 T1G987 20217634 PTHR43888:SF10 DNAJ-LIKE-2, ISOFORM A-RELATED DNAJ-LIKE-2, ISOFORM A protein binding#GO:0005515;protein-folding chaperone binding#GO:0051087;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG174051|UniProtKB=T1F7J2 T1F7J2 20204791 PTHR11461:SF211 SERINE PROTEASE INHIBITOR, SERPIN GH10112P-RELATED protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG169582|UniProtKB=T1F248 T1F248 20202898 PTHR47167:SF4 SERINE/THREONINE-PROTEIN KINASE TAO1-LIKE PROTEIN SERINE_THREONINE-PROTEIN KINASE TAO transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG79568|UniProtKB=T1G3Q2 T1G3Q2 20215700 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG141530|UniProtKB=T1EJ35 T1EJ35 20196585 PTHR46756:SF18 TRANSGELIN GAS2-LIKE PROTEIN PICKLED EGGS cytoskeletal protein binding#GO:0008092;molecular adaptor activity#GO:0060090;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;actin filament binding#GO:0051015;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 supramolecular complex#GO:0099080;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;supramolecular fiber#GO:0099512;supramolecular polymer#GO:0099081;actin filament#GO:0005884;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG175117|UniProtKB=T1F8V8 T1F8V8 20205257 PTHR34009:SF2 PROTEIN STAR PROTEIN STAR localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;endosomal transport#GO:0016197;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987 bounding membrane of organelle#GO:0098588;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;late endosome membrane#GO:0031902;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;endosome membrane#GO:0010008;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle membrane#GO:0030659;endoplasmic reticulum#GO:0005783;late endosome#GO:0005770;plasma membrane#GO:0005886;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG69777|UniProtKB=T1FZY4 T1FZY4 20214382 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG177168|UniProtKB=T1FBB1 T1FBB1 20206110 PTHR31797:SF6 EXTRACELLULAR MATRIX PROTEIN A-RELATED CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG78097|UniProtKB=T1G377 T1G377 20215525 PTHR21258:SF61 DOCKING PROTEIN RELATED PROTEIN CHICO regulation of biological process#GO:0050789;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG105484|UniProtKB=T1EDV5 T1EDV5 20194757 PTHR11472:SF1 DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD ATP-dependent activity, acting on DNA#GO:0008094;nucleic acid binding#GO:0003676;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;damaged DNA binding#GO:0003684;catalytic activity, acting on a nucleic acid#GO:0140640;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097 cellular aromatic compound metabolic process#GO:0006725;positive regulation of nitrogen compound metabolic process#GO:0051173;DNA-templated transcription#GO:0006351;regulation of nitrogen compound metabolic process#GO:0051171;RNA metabolic process#GO:0016070;regulation of DNA metabolic process#GO:0051052;positive regulation of cellular metabolic process#GO:0031325;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;cellular nitrogen compound biosynthetic process#GO:0044271;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;organic cyclic compound biosynthetic process#GO:1901362;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;regulation of DNA recombination#GO:0000018;transcription by RNA polymerase II#GO:0006366;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA helicase#PC00011;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG192804|UniProtKB=T1FUB3 T1FUB3 20212409 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG91460|UniProtKB=T1G841 T1G841 20217238 PTHR11904:SF9 METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;pentosyltransferase activity#GO:0016763 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 nucleotide kinase#PC00172;transferase#PC00220;metabolite interconversion enzyme#PC00262 Adenine and hypoxanthine salvage pathway#P02723>Inosine phosphorylase#P02813;Adenine and hypoxanthine salvage pathway#P02723>Adenine phosphorylase#P02805;Xanthine and guanine salvage pathway#P02788>Guanosine phosphorylase#P03250;Adenine and hypoxanthine salvage pathway#P02723>Deoxyadenosine phosphorylase#P02808;Xanthine and guanine salvage pathway#P02788>Deoxyguanosine phosphorylase#P03248;Adenine and hypoxanthine salvage pathway#P02723>Deoxyinosine phosphorylase#P02812 HELRO|EnsemblGenome=HelroG155960|UniProtKB=T1ELP7 T1ELP7 20197497 PTHR45885:SF1 CELL DIVISION CYCLE 5-LIKE PROTEIN CELL DIVISION CYCLE 5-LIKE PROTEIN cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;Prp19 complex#GO:0000974;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG192509|UniProtKB=T1FU13 T1FU13 20212309 PTHR22948:SF65 TUDOR DOMAIN CONTAINING PROTEIN A-KINASE ANCHORING PROTEIN 1 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG73359|UniProtKB=T1G1D2 T1G1D2 20214880 PTHR12722:SF0 XAP-5 PROTEIN-RELATED PROTEIN FAM50A cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;protein-DNA complex organization#GO:0071824;cellular component organization#GO:0016043;cellular process#GO:0009987;protein-containing complex organization#GO:0043933 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG90708|UniProtKB=T1G7U7 T1G7U7 20217144 PTHR12245:SF13 SPRY DOMAIN CONTAINING SOCS BOX PROTEIN B30.2_SPRY DOMAIN-CONTAINING PROTEIN macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG192301|UniProtKB=T1FTT1 T1FTT1 20212228 PTHR15952:SF11 EXPORTIN-T/LOS1 EXPORTIN-T tRNA binding#GO:0000049;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular localization#GO:0051641;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;RNA localization#GO:0006403;localization#GO:0051179;organic substance transport#GO:0071702;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169 envelope#GO:0031975;membrane-enclosed lumen#GO:0031974;nuclear pore#GO:0005643;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;nuclear periphery#GO:0034399;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG188138|UniProtKB=T1FPP2 T1FPP2 20210789 PTHR23261:SF77 GROUNDHOG-RELATED GROUND-LIKE DOMAIN-CONTAINING PROTEIN intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG184018|UniProtKB=T1FKF6 T1FKF6 20209305 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG179683|UniProtKB=T1FF09 T1FF09 20207408 PTHR31802:SF31 32 KDA HEAT SHOCK PROTEIN-RELATED MSR-110, ISOFORM C intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG107921|UniProtKB=T1EED9 T1EED9 20194941 PTHR45752:SF198 LEUCINE-RICH REPEAT-CONTAINING LEUCINE-RICH REPEAT-CONTAINING PROTEIN 40 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG175580|UniProtKB=T1F9E3 T1F9E3 20205442 PTHR18853:SF10 FORKHEAD-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1-RELATED FHA DOMAIN-CONTAINING PROTEIN helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG182090|UniProtKB=T1FHQ3 T1FHQ3 20208352 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193759|UniProtKB=T1FVB8 T1FVB8 20212764 PTHR24349:SF527 SERINE/THREONINE-PROTEIN KINASE LD17393P transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein serine/threonine kinase activity#GO:0004674;protein binding#GO:0005515;calmodulin binding#GO:0005516;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG67291|UniProtKB=T1FYZ3 T1FYZ3 20214041 PTHR11165:SF24 SKP1 S-PHASE KINASE-ASSOCIATED PROTEIN 1 cullin family protein binding#GO:0097602;protein binding#GO:0005515;binding#GO:0005488 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG180291|UniProtKB=T1FFP5 T1FFP5 20207644 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG177786|UniProtKB=T1FC96 T1FC96 20206445 PTHR10281:SF106 MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED IP06960P-RELATED cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG177648|UniProtKB=T1FC04 T1FC04 20206353 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174209|UniProtKB=T1F7S8 T1F7S8 20204877 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194028|UniProtKB=T1FVL1 T1FVL1 20212857 PTHR24112:SF66 LEUCINE-RICH REPEAT, ISOFORM F-RELATED LEUCINE-RICH REPEAT, ISOFORM F regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;regulation of organelle organization#GO:0033043;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament organization#GO:0110053;regulation of cellular component organization#GO:0051128;regulation of actin filament-based process#GO:0032970;cell motility#GO:0048870;cellular process#GO:0009987;cell migration#GO:0016477 cell leading edge#GO:0031252;lamellipodium#GO:0030027;cell projection#GO:0042995;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG180773|UniProtKB=T1FG95 T1FG95 20207844 PTHR46660:SF2 FAMILY NOT NAMED GLYCOSYLTRANSFERASE 1 DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG193118|UniProtKB=T1FUN1 T1FUN1 20212527 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189739|UniProtKB=T1FRB7 T1FRB7 20211364 PTHR46040:SF3 HIGH MOBILITY GROUP PROTEIN 2 HIGH MOBILITY GROUP PROTEIN 2 regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG162260|UniProtKB=T1ESF5 T1ESF5 20199505 PTHR46601:SF1 ULP_PROTEASE DOMAIN-CONTAINING PROTEIN ADF-H DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188005|UniProtKB=T1FPJ4 T1FPJ4 20210741 PTHR23206:SF8 MASK PROTEIN ANKYRIN REPEAT AND KH DOMAIN-CONTAINING 1 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG66673|UniProtKB=T1FYN7 T1FYN7 20213935 PTHR43722:SF1 PROLINE IMINOPEPTIDASE PROLINE IMINOPEPTIDASE serine protease#PC00203 HELRO|EnsemblGenome=HelroG162346|UniProtKB=T1ESJ2 T1ESJ2 20199542 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG82229|UniProtKB=T1G4P5 T1G4P5 20216043 PTHR24064:SF445 SOLUTE CARRIER FAMILY 22 MEMBER AT15560P-RELATED secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG170417|UniProtKB=T1F312 T1F312 20203211 PTHR33273:SF4 DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170017|UniProtKB=T1F2J3 T1F2J3 20203043 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179591|UniProtKB=T1FEX0 T1FEX0 20207369 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG103045|UniProtKB=T1EDD9 T1EDD9 20194591 PTHR24379:SF127 KRAB AND ZINC FINGER DOMAIN-CONTAINING BLOODY FINGERS-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG170390|UniProtKB=T1F2Z9 T1F2Z9 20203198 PTHR10024:SF227 SYNAPTOTAGMIN SYNAPTOTAGMIN 1 cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;phosphatidylserine binding#GO:0001786;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;protein binding#GO:0005515;clathrin binding#GO:0030276;lipid binding#GO:0008289;ion binding#GO:0043167;phospholipid binding#GO:0005543;SNARE binding#GO:0000149 cellular localization#GO:0051641;synaptic vesicle cycle#GO:0099504;synaptic vesicle endocytosis#GO:0048488;transport#GO:0006810;regulation of biological process#GO:0050789;regulated exocytosis#GO:0045055;synaptic vesicle recycling#GO:0036465;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;secretion#GO:0046903;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;signal release#GO:0023061;calcium-ion regulated exocytosis#GO:0017156;cell-cell signaling#GO:0007267;signaling#GO:0023052;synaptic vesicle exocytosis#GO:0016079;secretion by cell#GO:0032940;neurotransmitter secretion#GO:0007269;endocytosis#GO:0006897;trans-synaptic signaling#GO:0099537;vesicle-mediated transport#GO:0016192;cell communication#GO:0007154;cellular process#GO:0009987;localization#GO:0051179;signal release from synapse#GO:0099643;exocytosis#GO:0006887;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;import into cell#GO:0098657;export from cell#GO:0140352;vesicle-mediated transport in synapse#GO:0099003 intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;secretory vesicle#GO:0099503;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG87639|UniProtKB=T1G6T4 T1G6T4 20216781 PTHR13250:SF1 TF-1 CELL APOPTOSIS RELATED PROTEIN-15 PROGRAMMED CELL DEATH PROTEIN 10 enzyme binding#GO:0019899;protein binding#GO:0005515;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of MAPK cascade#GO:0043408;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of signal transduction#GO:0009967;positive regulation of cellular metabolic process#GO:0031325;regulation of signaling#GO:0023051;positive regulation of molecular function#GO:0044093;regulation of cellular component organization#GO:0051128;regulation of catalytic activity#GO:0050790;positive regulation of protein modification process#GO:0031401;regulation of intracellular signal transduction#GO:1902531;positive regulation of MAPK cascade#GO:0043410;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of response to stimulus#GO:0048584;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;regulation of signal transduction#GO:0009966;regulation of protein serine/threonine kinase activity#GO:0071900;positive regulation of intracellular signal transduction#GO:1902533;regulation of MAP kinase activity#GO:0043405;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;regulation of kinase activity#GO:0043549;positive regulation of protein phosphorylation#GO:0001934;regulation of protein kinase activity#GO:0045859;regulation of cell communication#GO:0010646;positive regulation of phosphorylation#GO:0042327;positive regulation of catalytic activity#GO:0043085;regulation of organelle organization#GO:0033043;positive regulation of phosphorus metabolic process#GO:0010562;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of protein serine/threonine kinase activity#GO:0071902;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;regulation of primary metabolic process#GO:0080090;positive regulation of protein metabolic process#GO:0051247;positive regulation of phosphate metabolic process#GO:0045937;positive regulation of protein kinase activity#GO:0045860;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of protein phosphorylation#GO:0001932;positive regulation of cell communication#GO:0010647;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG180365|UniProtKB=T1FFU3 T1FFU3 20207692 PTHR15081:SF1 NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED NUCLEAR AUTOANTIGENIC SPERM PROTEIN protein binding#GO:0005515;binding#GO:0005488;histone binding#GO:0042393 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;organelle organization#GO:0006996;chromosome organization#GO:0051276;protein-containing complex organization#GO:0043933;protein-containing complex assembly#GO:0065003;chromatin organization#GO:0006325;cellular component organization#GO:0016043;cellular process#GO:0009987;chromatin remodeling#GO:0006338;protein-DNA complex assembly#GO:0065004 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG80245|UniProtKB=T1G3Z2 T1G3Z2 20215790 PTHR24637:SF377 COLLAGEN COLLAGEN TYPE IX ALPHA 1 CHAIN HELRO|EnsemblGenome=HelroG190236|UniProtKB=T1FRT1 T1FRT1 20211528 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG74104|UniProtKB=T1G1M4 T1G1M4 20214972 PTHR12547:SF18 CCCH ZINC FINGER/TIS11-RELATED PROTEIN TIS11 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG84726|UniProtKB=T1G5M7 T1G5M7 20216374 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG83911|UniProtKB=T1G5B7 T1G5B7 20216264 PTHR47835:SF3 HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG HELICASE FOR MEIOSIS 1 HELRO|EnsemblGenome=HelroG183140|UniProtKB=T1FJ70 T1FJ70 20208869 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184240|UniProtKB=T1FKU1 T1FKU1 20209440 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166215|UniProtKB=T1EXW9 T1EXW9 20201419 PTHR23354:SF62 NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED MUSTARD, ISOFORM V HELRO|EnsemblGenome=HelroG116769|UniProtKB=T1EGH5 T1EGH5 20195677 PTHR11556:SF1 FRUCTOSE-1,6-BISPHOSPHATASE-RELATED FRUCTOSE-BISPHOSPHATASE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;sugar-phosphatase activity#GO:0050308;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 monosaccharide metabolic process#GO:0005996;carbohydrate biosynthetic process#GO:0016051;carbohydrate derivative metabolic process#GO:1901135;cellular metabolic process#GO:0044237;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;glucose metabolic process#GO:0006006;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;hexose biosynthetic process#GO:0019319;oligosaccharide biosynthetic process#GO:0009312;organophosphate metabolic process#GO:0019637;small molecule biosynthetic process#GO:0044283;hexose metabolic process#GO:0019318;carbohydrate metabolic process#GO:0005975;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 carbohydrate phosphatase#PC00066;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG170801|UniProtKB=T1F3G0 T1F3G0 20203359 PTHR14191:SF28 PDZ DOMAIN CONTAINING PROTEIN GH04176P-RELATED protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 localization#GO:0051179;protein localization to plasma membrane#GO:0072659;protein localization to cell periphery#GO:1990778;localization within membrane#GO:0051668;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;cellular process#GO:0009987;protein localization#GO:0008104 plasma membrane region#GO:0098590;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;apical part of cell#GO:0045177;plasma membrane#GO:0005886;apical plasma membrane#GO:0016324 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG114139|UniProtKB=T1EFZ6 T1EFZ6 20195498 PTHR10202:SF13 PRESENILIN PRESENILIN HOMOLOG hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 membrane protein proteolysis#GO:0033619;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;membrane protein ectodomain proteolysis#GO:0006509;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 aspartic protease#PC00053;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Presenilin N-terminal fragment#P00140;Notch signaling pathway#P00045>Presenilin#P01110;Alzheimer disease-amyloid secretase pathway#P00003>Presenilin N-terminal fragment#P00088;Alzheimer disease-amyloid secretase pathway#P00003>Presenilin C-terminal fragment#P00102;Alzheimer disease-presenilin pathway#P00004>Presenilin C-terminal fragment#P00155;Alzheimer disease-presenilin pathway#P00004>Presenilin#P00129;Alzheimer disease-amyloid secretase pathway#P00003>Presenilin#P00098 HELRO|EnsemblGenome=HelroG87553|UniProtKB=T1G6S1 T1G6S1 20216768 PTHR24243:SF208 G-PROTEIN COUPLED RECEPTOR PYROKININ-1 RECEPTOR G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG172045|UniProtKB=T1F4Z1 T1F4Z1 20203890 PTHR24403:SF67 ZINC FINGER PROTEIN FI01116P-RELATED regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG169662|UniProtKB=T1F274 T1F274 20202924 PTHR10882:SF0 DIPHTHINE SYNTHASE DIPHTHINE METHYL ESTER SYNTHASE methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG166825|UniProtKB=T1EYK9 T1EYK9 20201659 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162559|UniProtKB=T1ESU2 T1ESU2 20199642 PTHR19269:SF45 TROPOMYOSIN TROPOMYOSIN-1, ISOFORMS 33_34 cytoskeletal protein#PC00085;actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG78253|UniProtKB=T1G398 T1G398 20215546 PTHR10217:SF637 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL EAG-LIKE K[+] CHANNEL, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG175185|UniProtKB=T1F8Z2 T1F8Z2 20205291 PTHR46520:SF1 SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL hydrolase activity#GO:0016787;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;biological regulation#GO:0065007;organonitrogen compound metabolic process#GO:1901564;regulation of lipid metabolic process#GO:0019216;protein metabolic process#GO:0019538;regulation of metabolic process#GO:0019222;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG188385|UniProtKB=T1FPX9 T1FPX9 20210876 PTHR11824:SF5 VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT CA2+-CHANNEL-PROTEIN-BETA-SUBUNIT, ISOFORM L calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated calcium channel activity#GO:0005245;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;regulation of metal ion transport#GO:0010959;trans-synaptic signaling#GO:0099537;regulation of calcium ion transport#GO:0051924;regulation of localization#GO:0032879;regulation of monoatomic cation transmembrane transport#GO:1904062;cellular component organization#GO:0016043;cell communication#GO:0007154;cellular process#GO:0009987;neuromuscular junction development#GO:0007528;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;synapse organization#GO:0050808;regulation of transport#GO:0051049;chemical synaptic transmission#GO:0007268;anterograde trans-synaptic signaling#GO:0098916;regulation of molecular function#GO:0065009;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;biological regulation#GO:0065007;synaptic signaling#GO:0099536;regulation of monoatomic ion transmembrane transporter activity#GO:0032412;regulation of monoatomic ion transport#GO:0043269;regulation of transmembrane transporter activity#GO:0022898;regulation of transporter activity#GO:0032409;cell-cell signaling#GO:0007267;signaling#GO:0023052 voltage-gated calcium channel complex#GO:0005891;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;calcium channel complex#GO:0034704;membrane#GO:0016020;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227;voltage-gated ion channel#PC00241 Thyrotropin-releasing hormone receptor signaling pathway#P04394>Ca2+ channel#P04587 HELRO|EnsemblGenome=HelroG104858|UniProtKB=T1EDN9 T1EDN9 20194691 PTHR11207:SF5 RIBONUCLEASE III LARGE RIBOSOMAL SUBUNIT PROTEIN ML44 catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;nuclease activity#GO:0004518;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;endonuclease activity#GO:0004519;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;RNA nuclease activity#GO:0004540;double-stranded RNA binding#GO:0003725;RNA endonuclease activity#GO:0004521 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;RNA metabolic process#GO:0016070;peptide metabolic process#GO:0006518;mitochondrial gene expression#GO:0140053;regulatory ncRNA processing#GO:0070918;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;translation#GO:0006412;regulation of biological process#GO:0050789;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;cellular nitrogen compound biosynthetic process#GO:0044271;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;protein metabolic process#GO:0019538;negative regulation of cellular process#GO:0048523;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;miRNA processing#GO:0035196;heterocycle metabolic process#GO:0046483;regulatory ncRNA-mediated gene silencing#GO:0031047;macromolecule biosynthetic process#GO:0009059;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;mitochondrial translation#GO:0032543;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;negative regulation of metabolic process#GO:0009892;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;primary miRNA processing#GO:0031053;amide biosynthetic process#GO:0043604;negative regulation of macromolecule biosynthetic process#GO:0010558;peptide biosynthetic process#GO:0043043;nucleic acid metabolic process#GO:0090304;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;translational elongation#GO:0006414;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;endoribonuclease complex#GO:1902555;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;endonuclease complex#GO:1905348;intracellular organelle lumen#GO:0070013;mitochondrial large ribosomal subunit#GO:0005762;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein complex#GO:1990904;organellar ribosome#GO:0000313;protein-containing complex#GO:0032991;large ribosomal subunit#GO:0015934;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840;nuclear protein-containing complex#GO:0140513;mitochondrial protein-containing complex#GO:0098798 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG173449|UniProtKB=T1F6U6 T1F6U6 20204545 PTHR45636:SF41 PAIRED BOX PROTEIN PAX-6-RELATED-RELATED PAIRED BOX PROTEIN PAX-6-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG181067|UniProtKB=T1FGK6 T1FGK6 20207955 PTHR12424:SF8 TWEETY-RELATED PROTEIN TWEETY inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG194049|UniProtKB=T1FVM2 T1FVM2 20212868 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185774|UniProtKB=T1FN99 T1FN99 20210297 PTHR11635:SF152 CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 kinase modulator#PC00140 Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Cell cycle#P00013>Protein kinase subunit#P00482;GABA-B receptor II signaling#P05731>PKA#P05752;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Enkephalin release#P05913>PKA#P05972;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Transcription regulation by bZIP transcription factor#P00055>PKA#P01384;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Hedgehog signaling pathway#P00025>PKA#P00682;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059;Endothelin signaling pathway#P00019>PKA#P00570 HELRO|EnsemblGenome=HelroG77102|UniProtKB=T1G2T2 T1G2T2 20215380 PTHR12296:SF30 DENN DOMAIN-CONTAINING PROTEIN 4 DENN DOMAIN-CONTAINING PROTEIN CRAG regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;regulation of signaling#GO:0023051;biological regulation#GO:0065007;regulation of intracellular signal transduction#GO:1902531;regulation of small GTPase mediated signal transduction#GO:0051056 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG190437|UniProtKB=T1FRZ7 T1FRZ7 20211594 PTHR24023:SF1106 COLLAGEN ALPHA VIKING, ISOFORM A structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922 HELRO|EnsemblGenome=HelroG98385|UniProtKB=T1G9M2 T1G9M2 20217768 PTHR10985:SF138 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED HAIRY_ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 Notch signaling pathway#P00045>E(spl)-C genes#G01541 HELRO|EnsemblGenome=HelroG113995|UniProtKB=T1EFY0 T1EFY0 20195482 PTHR23205:SF0 SPLICING FACTOR 3A SUBUNIT 2 SPLICING FACTOR 3A SUBUNIT 2 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;mRNA splicing, via spliceosome#GO:0000398;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375;spliceosomal complex assembly#GO:0000245 catalytic step 2 spliceosome#GO:0071013;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;U2-type spliceosomal complex#GO:0005684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;U2 snRNP#GO:0005686;U2-type prespliceosome#GO:0071004;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG97921|UniProtKB=T1G9J5 T1G9J5 20217741 PTHR24068:SF460 UBIQUITIN-CONJUGATING ENZYME E2 BCDNA.GH02435 ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E2#P01491 HELRO|EnsemblGenome=HelroG171815|UniProtKB=T1F4Q6 T1F4Q6 20203805 PTHR46543:SF1 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;modification-dependent macromolecule catabolic process#GO:0043632;regulation of biological process#GO:0050789;ncRNA metabolic process#GO:0034660;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;mRNA catabolic process#GO:0006402;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;negative regulation of cellular process#GO:0048523;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;snRNA metabolic process#GO:0016073;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;nuclear-transcribed mRNA catabolic process#GO:0000956;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;rRNA metabolic process#GO:0016072;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;polyadenylation-dependent ncRNA catabolic process#GO:0043634;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG174255|UniProtKB=T1F7W4 T1F7W4 20204913 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG94763|UniProtKB=T1G929 T1G929 20217576 PTHR18929:SF210 PROTEIN DISULFIDE ISOMERASE PROTEIN DISULFIDE-ISOMERASE A4 isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;protein disulfide isomerase activity#GO:0003756 cellular response to stimulus#GO:0051716;macromolecule biosynthetic process#GO:0009059;response to endoplasmic reticulum stress#GO:0034976;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;response to stress#GO:0006950;protein folding#GO:0006457;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cell surface#GO:0009986;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG65703|UniProtKB=T1FYB7 T1FYB7 20213815 PTHR46989:SF3 USP DOMAIN-CONTAINING PROTEIN USPA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG64650|UniProtKB=T1FXX5 T1FXX5 20213673 PTHR46485:SF5 LIM DOMAIN KINASE 1 CENTER DIVIDER, ISOFORM A HELRO|EnsemblGenome=HelroG72687|UniProtKB=T1G141 T1G141 20214789 PTHR21637:SF0 BTB/POZ DOMAIN-CONTAINING PROTEIN 10-RELATED AT10158P regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of phosphorylation#GO:0042327;regulation of phosphate metabolic process#GO:0019220;positive regulation of metabolic process#GO:0009893;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;positive regulation of cellular metabolic process#GO:0031325;biological regulation#GO:0065007;positive regulation of phosphorus metabolic process#GO:0010562;regulation of phosphorylation#GO:0042325;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG106063|UniProtKB=T1EDZ9 T1EDZ9 20194801 PTHR22599:SF11 MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB MOB KINASE ACTIVATOR-LIKE 3 protein kinase activator activity#GO:0030295;protein kinase regulator activity#GO:0019887;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234;kinase activator activity#GO:0019209 positive regulation of nitrogen compound metabolic process#GO:0051173;signal transduction#GO:0007165;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;positive regulation of protein modification process#GO:0031401;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of metabolic process#GO:0009893;positive regulation of biological process#GO:0048518;signaling#GO:0023052;positive regulation of protein phosphorylation#GO:0001934;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;positive regulation of protein metabolic process#GO:0051247;positive regulation of phosphate metabolic process#GO:0045937;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of protein phosphorylation#GO:0001932;biological regulation#GO:0065007;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 kinase modulator#PC00140;kinase activator#PC00138 HELRO|EnsemblGenome=HelroG192000|UniProtKB=T1FTH9 T1FTH9 20212126 PTHR36498:SF1 TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172 TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172 HELRO|EnsemblGenome=HelroG187909|UniProtKB=T1FPG7 T1FPG7 20210714 PTHR11361:SF148 DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER DNA MISMATCH REPAIR PROTEIN MSH6 nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;mismatch repair#GO:0006298;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG77345|UniProtKB=T1G2W6 T1G2W6 20215414 PTHR10134:SF20 CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL-RELATED oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG194777|UniProtKB=T1FWE3 T1FWE3 20213138 PTHR14107:SF16 WD REPEAT PROTEIN AT02583P HELRO|EnsemblGenome=HelroG185163|UniProtKB=T1FMG6 T1FMG6 20210015 PTHR12411:SF917 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN L cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197 macromolecule catabolic process#GO:0009057;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;proteolysis#GO:0006508;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;catabolic process#GO:0009056;organonitrogen compound catabolic process#GO:1901565;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;lysosome#GO:0005764;intracellular membrane-bounded organelle#GO:0043231;extracellular region#GO:0005576;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;organelle#GO:0043226;lytic vacuole#GO:0000323;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG157537|UniProtKB=T1EMC8 T1EMC8 20197728 PTHR13481:SF0 SREBP REGULATING GENE PROTEIN SREBP REGULATING GENE PROTEIN HELRO|EnsemblGenome=HelroG185103|UniProtKB=T1FME4 T1FME4 20209993 PTHR47385:SF14 CALPONIN TRANSGELIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG115469|UniProtKB=T1EG84 T1EG84 20195586 PTHR43128:SF16 L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)) L-LACTATE DEHYDROGENASE oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 organic hydroxy compound metabolic process#GO:1901615;oxoacid metabolic process#GO:0043436;cellular metabolic process#GO:0044237;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG105051|UniProtKB=T1EDQ1 T1EDQ1 20194703 PTHR13208:SF2 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4 molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;core mediator complex#GO:0070847;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG110114|UniProtKB=T1EEZ3 T1EEZ3 20195145 PTHR46356:SF1 MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG172961|UniProtKB=T1F677 T1F677 20204326 PTHR46954:SF1 C2H2-TYPE DOMAIN-CONTAINING PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180729|UniProtKB=T1FG77 T1FG77 20207826 PTHR13283:SF11 KREV INTERACTION TRAPPED 1-RELATED KREV INTERACTION TRAPPED PROTEIN 1 regulation of biological process#GO:0050789;negative regulation of multicellular organismal process#GO:0051241;negative regulation of biological process#GO:0048519;regulation of multicellular organismal process#GO:0051239;regulation of developmental process#GO:0050793;regulation of anatomical structure morphogenesis#GO:0022603;regulation of vasculature development#GO:1901342;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;homeostatic process#GO:0042592;regulation of angiogenesis#GO:0045765;negative regulation of angiogenesis#GO:0016525;regulation of multicellular organismal development#GO:2000026;cellular homeostasis#GO:0019725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG158479|UniProtKB=T1EMU6 T1EMU6 20197896 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188988|UniProtKB=T1FQJ2 T1FQJ2 20211089 PTHR46186:SF2 CYSTATIN CYSTATIN peptidase inhibitor activity#GO:0030414;molecular function regulator activity#GO:0098772;cysteine-type endopeptidase inhibitor activity#GO:0004869;peptidase regulator activity#GO:0061134;enzyme inhibitor activity#GO:0004857;endopeptidase regulator activity#GO:0061135;endopeptidase inhibitor activity#GO:0004866;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 regulation of proteolysis#GO:0030162;negative regulation of hydrolase activity#GO:0051346;negative regulation of biological process#GO:0048519;regulation of protein metabolic process#GO:0051246;regulation of cysteine-type endopeptidase activity#GO:2000116;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of cysteine-type endopeptidase activity#GO:2000117;negative regulation of peptidase activity#GO:0010466;negative regulation of endopeptidase activity#GO:0010951;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of proteolysis#GO:0045861;regulation of catalytic activity#GO:0050790;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of molecular function#GO:0065009;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336;regulation of endopeptidase activity#GO:0052548;regulation of peptidase activity#GO:0052547;negative regulation of catalytic activity#GO:0043086;regulation of metabolic process#GO:0019222;negative regulation of molecular function#GO:0044092 cytoplasm#GO:0005737;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG89451|UniProtKB=T1G7D0 T1G7D0 20216977 PTHR24064:SF577 SOLUTE CARRIER FAMILY 22 MEMBER GH09241P secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG148455|UniProtKB=T1EK87 T1EK87 20196987 PTHR28596:SF1 BBSOME-INTERACTING PROTEIN 1 BBSOME-INTERACTING PROTEIN 1 localization#GO:0051179;protein localization to cell periphery#GO:1990778;localization within membrane#GO:0051668;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;protein localization to cilium#GO:0061512;protein localization to membrane#GO:0072657;protein localization to organelle#GO:0033365;cellular process#GO:0009987;protein localization#GO:0008104 protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;BBSome#GO:0034464;cilium#GO:0005929;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025 HELRO|EnsemblGenome=HelroG172527|UniProtKB=T1F5G7 T1F5G7 20204066 PTHR33562:SF28 ATILLA, ISOFORM B-RELATED-RELATED PROTEIN QUIVER HELRO|EnsemblGenome=HelroG177574|UniProtKB=T1FBW1 T1FBW1 20206310 PTHR44755:SF11 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED ATRIAL NATRIURETIC PEPTIDE RECEPTOR 3 ISOFORM X1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide hormone binding#GO:0017046;hormone binding#GO:0042562;binding#GO:0005488;peptide binding#GO:0042277;amide binding#GO:0033218 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG136785|UniProtKB=T1EIF8 T1EIF8 20196358 PTHR10845:SF192 REGULATOR OF G PROTEIN SIGNALING DOUBLE HIT, ISOFORM B G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731 HELRO|EnsemblGenome=HelroG182562|UniProtKB=T1FIC7 T1FIC7 20208576 PTHR13297:SF9 TBC1 DOMAIN FAMILY MEMBER 23-RELATED ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG189999|UniProtKB=T1FRK8 T1FRK8 20211455 PTHR45937:SF1 ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1 ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG182167|UniProtKB=T1FHU9 T1FHU9 20208398 PTHR10794:SF63 ABHYDROLASE DOMAIN-CONTAINING PROTEIN ALPHA_BETA HYDROLASE 1, ISOFORM A hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;lipase activity#GO:0016298;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;cellular metabolic process#GO:0044237;cellular process#GO:0009987;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238;metabolic process#GO:0008152 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG83852|UniProtKB=T1G5B0 T1G5B0 20216257 PTHR45589:SF1 WD REPEAT DOMAIN 62, ISOFORM G WD REPEAT DOMAIN 62, ISOFORM G HELRO|EnsemblGenome=HelroG193255|UniProtKB=T1FUS9 T1FUS9 20212575 PTHR23302:SF24 TRANSMEMBRANE CHANNEL-RELATED TMC DOMAIN-CONTAINING PROTEIN ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG165128|UniProtKB=T1EWB3 T1EWB3 20200863 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163144|UniProtKB=T1ETQ2 T1ETQ2 20199952 PTHR24034:SF209 EGF-LIKE DOMAIN-CONTAINING PROTEIN EGF-LIKE DOMAIN-CONTAINING PROTEIN extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG173218|UniProtKB=T1F6K9 T1F6K9 20204458 PTHR46169:SF29 DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG76232|UniProtKB=T1G2G9 T1G2G9 20215267 PTHR24347:SF412 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE H1 HOMOLOG-RELATED non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CaMK#P00847;Ionotropic glutamate receptor pathway#P00037>CaMKII#P01023 HELRO|EnsemblGenome=HelroG162249|UniProtKB=T1ESE8 T1ESE8 20199498 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186263|UniProtKB=T1FNW0 T1FNW0 20210507 PTHR15451:SF19 ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG115941|UniProtKB=T1EGB9 T1EGB9 20195621 PTHR12317:SF79 DIACYLGLYCEROL O-ACYLTRANSFERASE ACYLTRANSFERASE acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;O-acyltransferase activity#GO:0008374 lipid metabolic process#GO:0006629;triglyceride metabolic process#GO:0006641;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;acylglycerol metabolic process#GO:0006639;lipid biosynthetic process#GO:0008610;primary metabolic process#GO:0044238;neutral lipid metabolic process#GO:0006638;glycerolipid metabolic process#GO:0046486;triglyceride biosynthetic process#GO:0019432;cellular lipid metabolic process#GO:0044255;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG191127|UniProtKB=T1FSM4 T1FSM4 20211821 PTHR13808:SF1 CBP/P300-RELATED HISTONE ACETYLTRANSFERASE histone modifying activity#GO:0140993;nucleic acid binding#GO:0003676;acyltransferase activity#GO:0016746;peptide N-acetyltransferase activity#GO:0034212;binding#GO:0005488;catalytic activity#GO:0003824;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;N-acyltransferase activity#GO:0016410;histone acetyltransferase activity#GO:0004402;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;molecular adaptor activity#GO:0060090;N-acetyltransferase activity#GO:0008080;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;chromatin DNA binding#GO:0031490;transferase activity#GO:0016740;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;protein-containing complex binding#GO:0044877;catalytic activity, acting on a protein#GO:0140096 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of RNA metabolic process#GO:0051254;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;chromatin#GO:0000785;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;chromosome#GO:0005694 histone modifying enzyme#PC00261 DPP signaling pathway#P06213>NEJ#P06284;TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282;SCW signaling pathway#P06216>NEJ#P06328;GBB signaling pathway#P06214>NEJ#P06295;BMP/activin signaling pathway-drosophila#P06211>NEJ#P06246;p53 pathway#P00059>CBP#P04623;Wnt signaling pathway#P00057>CBP#P01448;Transcription regulation by bZIP transcription factor#P00055>CBP/P300#P01387;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CREB#P00713;DPP-SCW signaling pathway#P06212>NEJ#P06260;Huntington disease#P00029>CBP#P00777 HELRO|EnsemblGenome=HelroG174401|UniProtKB=T1F830 T1F830 20204979 PTHR21026:SF2 39S RIBOSOMAL PROTEIN L32, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN BL32M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG63110|UniProtKB=T1FXB0 T1FXB0 20213458 PTHR13697:SF4 PHOSPHOFRUCTOKINASE ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;phosphotransferase activity, alcohol group as acceptor#GO:0016773;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;carbohydrate kinase activity#GO:0019200;carbohydrate binding#GO:0030246;kinase activity#GO:0016301;cation binding#GO:0043169;transferase activity#GO:0016740;organic cyclic compound binding#GO:0097159;identical protein binding#GO:0042802;nucleoside phosphate binding#GO:1901265;protein binding#GO:0005515;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;ATP binding#GO:0005524;monosaccharide binding#GO:0048029 ribonucleoside triphosphate metabolic process#GO:0009199;nucleoside triphosphate metabolic process#GO:0009141;heterocycle catabolic process#GO:0046700;ribonucleotide catabolic process#GO:0009261;pyridine nucleotide metabolic process#GO:0019362;nucleobase-containing compound metabolic process#GO:0006139;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;purine ribonucleotide catabolic process#GO:0009154;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;oxoacid metabolic process#GO:0043436;nucleoside phosphate catabolic process#GO:1901292;carbohydrate derivative catabolic process#GO:1901136;purine ribonucleoside triphosphate metabolic process#GO:0009205;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;nucleotide catabolic process#GO:0009166;cellular nitrogen compound metabolic process#GO:0034641;nicotinamide nucleotide metabolic process#GO:0046496;nucleoside diphosphate catabolic process#GO:0009134;organic acid metabolic process#GO:0006082;ribonucleotide metabolic process#GO:0009259;monocarboxylic acid metabolic process#GO:0032787;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;organophosphate catabolic process#GO:0046434;small molecule catabolic process#GO:0044282;glycolytic process#GO:0006096;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;nucleotide metabolic process#GO:0009117;small molecule metabolic process#GO:0044281;cellular aromatic compound metabolic process#GO:0006725;monosaccharide metabolic process#GO:0005996;carbohydrate derivative metabolic process#GO:1901135;organonitrogen compound catabolic process#GO:1901565;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;purine-containing compound catabolic process#GO:0072523;cellular nitrogen compound catabolic process#GO:0044270;purine nucleotide catabolic process#GO:0006195;organic cyclic compound metabolic process#GO:1901360;carbohydrate catabolic process#GO:0016052;nucleoside diphosphate metabolic process#GO:0009132;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carbohydrate metabolic process#GO:0005975;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;heterocycle metabolic process#GO:0046483;organonitrogen compound metabolic process#GO:1901564;cellular process#GO:0009987;glucose metabolic process#GO:0006006;aromatic compound catabolic process#GO:0019439;organic cyclic compound catabolic process#GO:1901361;purine nucleoside triphosphate metabolic process#GO:0009144;hexose metabolic process#GO:0019318;carboxylic acid metabolic process#GO:0019752;nucleobase-containing small molecule metabolic process#GO:0055086 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695 carbohydrate kinase#PC00065 Glycolysis#P00024>Phosphofructokinase-1#P00672 HELRO|EnsemblGenome=HelroG81831|UniProtKB=T1G4J3 T1G4J3 20215991 PTHR23264:SF35 NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1 small molecule binding#GO:0036094;binding#GO:0005488;iron-sulfur cluster binding#GO:0051536 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;iron-sulfur cluster assembly#GO:0016226;cellular component organization#GO:0016043;cellular process#GO:0009987 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG183443|UniProtKB=T1FJN8 T1FJN8 20209037 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG75154|UniProtKB=T1G216 T1G216 20215114 PTHR10655:SF17 LYSOPHOSPHOLIPASE-RELATED LYSOPHOSPHOLIPASE-LIKE PROTEIN 1 phospholipase#PC00186;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG157967|UniProtKB=T1EMI2 T1EMI2 20197782 PTHR12144:SF0 NEGATIVE ELONGATION FACTOR D NEGATIVE ELONGATION FACTOR C_D nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of DNA-templated transcription elongation#GO:0032784;regulation of transcription elongation by RNA polymerase II#GO:0034243;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;transcription elongation factor complex#GO:0008023;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG153339|UniProtKB=T1EL43 T1EL43 20197293 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193374|UniProtKB=T1FUX5 T1FUX5 20212621 PTHR23354:SF62 NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED MUSTARD, ISOFORM V HELRO|EnsemblGenome=HelroG188931|UniProtKB=T1FQH8 T1FQH8 20211075 PTHR19879:SF1 TRANSCRIPTION INITIATION FACTOR TFIID CANNONBALL-RELATED cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;transcription initiation at RNA polymerase II promoter#GO:0006367;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nucleobase-containing compound biosynthetic process#GO:0034654;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;transcription factor TFIID complex#GO:0005669;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase II, holoenzyme#GO:0016591;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG65068|UniProtKB=T1FY28 T1FY28 20213726 PTHR45942:SF1 PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1 PROTEIN PHOSPHATASE 3 REGULATORY SUBUNIT B, ALPHA phosphatase binding#GO:0019902;phosphatase regulator activity#GO:0019208;binding#GO:0005488;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888;protein binding#GO:0005515;enzyme binding#GO:0019899;enzyme regulator activity#GO:0030234 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;calcium-mediated signaling#GO:0019722;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;calcineurin-mediated signaling#GO:0097720;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;cell communication#GO:0007154;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;dephosphorylation#GO:0016311;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 protein serine/threonine phosphatase complex#GO:0008287;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;catalytic complex#GO:1902494 Wnt signaling pathway#P00057>Calcineurin#P01446 HELRO|EnsemblGenome=HelroG185934|UniProtKB=T1FNG4 T1FNG4 20210361 PTHR13074:SF9 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG143376|UniProtKB=T1EJA4 T1EJA4 20196654 PTHR14742:SF0 RIBONUCLEASE P SUBUNIT P21 RIBONUCLEASE P PROTEIN SUBUNIT P21 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG160736|UniProtKB=T1EQN4 T1EQN4 20198884 PTHR11927:SF9 GALACTOSIDE 2-L-FUCOSYLTRANSFERASE L-FUCOSYLTRANSFERASE transferase activity#GO:0016740;fucosyltransferase activity#GO:0008417;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein glycosylation#GO:0006486;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycosylation#GO:0070085;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG113731|UniProtKB=T1EFV7 T1EFV7 20195459 PTHR12625:SF0 LIPOCALIN-1 INTERACTING MEMBRANE RECEPTOR LIMR PROTEIN LILIPOD signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG177306|UniProtKB=T1FBH3 T1FBH3 20206172 PTHR10649:SF12 ARYL HYDROCARBON RECEPTOR SPINELESS, ISOFORM C sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;molecular transducer activity#GO:0060089;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG162055|UniProtKB=T1ES72 T1ES72 20199422 PTHR37162:SF1 HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED BED-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163750|UniProtKB=T1EUF0 T1EUF0 20200200 PTHR19325:SF575 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING LOCOMOTION-RELATED PROTEIN HIKARU GENKI complement component#PC00078 HELRO|EnsemblGenome=HelroG160686|UniProtKB=T1EQL5 T1EQL5 20198865 PTHR14596:SF72 ZINC FINGER PROTEIN ZINC FINGER PROTEIN MSN2-RELATED cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to nutrient levels#GO:0031667;response to extracellular stimulus#GO:0009991;response to stress#GO:0006950;response to starvation#GO:0042594 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG189252|UniProtKB=T1FQV4 T1FQV4 20211201 PTHR13930:SF0 S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED lyase#PC00144 HELRO|EnsemblGenome=HelroG160496|UniProtKB=T1EQB5 T1EQB5 20198765 PTHR24121:SF32 NO MECHANORECEPTOR POTENTIAL C, ISOFORM D-RELATED DEATH DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172239|UniProtKB=T1F558 T1F558 20203957 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG173888|UniProtKB=T1F7C2 T1F7C2 20204721 PTHR13159:SF0 RADIAL SPOKEHEAD-RELATED RADIAL SPOKE HEAD 6 HOMOLOG A cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;microtubule cytoskeleton organization#GO:0000226;microtubule-based movement#GO:0007018;cellular component organization#GO:0016043;axoneme assembly#GO:0035082;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;cilium movement#GO:0003341;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;microtubule bundle formation#GO:0001578;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection assembly#GO:0120031 axoneme#GO:0005930;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;plasma membrane bounded cell projection cytoplasm#GO:0032838;membrane-bounded organelle#GO:0043227;ciliary plasm#GO:0097014;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG166029|UniProtKB=T1EXM1 T1EXM1 20201321 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178815|UniProtKB=T1FDS3 T1FDS3 20206972 PTHR46513:SF13 VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG83199|UniProtKB=T1G519 T1G519 20216167 PTHR24073:SF839 DRAB5-RELATED RAS-RELATED PROTEIN RAB-38 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;pigmentation#GO:0043473;nitrogen compound transport#GO:0071705;cellular component organization#GO:0016043;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;organelle organization#GO:0006996;protein transport#GO:0015031;melanosome organization#GO:0032438;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;vesicle organization#GO:0016050;intracellular transport#GO:0046907 trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;organelle subcompartment#GO:0031984;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;melanosome#GO:0042470;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;Golgi apparatus subcompartment#GO:0098791 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG177651|UniProtKB=T1FC07 T1FC07 20206356 PTHR46641:SF25 FMRFAMIDE RECEPTOR-RELATED CNMAMIDE RECEPTOR-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG159038|UniProtKB=T1ENI4 T1ENI4 20198134 PTHR12280:SF20 PANTOTHENATE KINASE 4'-PHOSPHOPANTETHEINE PHOSPHATASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 kinase#PC00137 Coenzyme A biosynthesis#P02736>Pantothenate kinase#P02885 HELRO|EnsemblGenome=HelroG188504|UniProtKB=T1FQ23 T1FQ23 20210920 PTHR12419:SF10 OTU DOMAIN CONTAINING PROTEIN DEUBIQUITINASE OTUD6B cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG193656|UniProtKB=T1FV85 T1FV85 20212731 PTHR10910:SF62 EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN AT07585P-RELATED nucleic acid binding#GO:0003676;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;adenosine deaminase activity#GO:0004000;RNA binding#GO:0003723;tRNA-specific adenosine deaminase activity#GO:0008251;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;deaminase activity#GO:0019239;double-stranded RNA binding#GO:0003725 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;adenosine to inosine editing#GO:0006382;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG86965|UniProtKB=T1G6K0 T1G6K0 20216697 PTHR11679:SF85 VESICLE PROTEIN SORTING-ASSOCIATED VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 33A cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle tethering complex#GO:0099023;vacuole#GO:0005773;cellular anatomical entity#GO:0110165;organelle#GO:0043226;lytic vacuole#GO:0000323;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;lysosome#GO:0005764;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG76167|UniProtKB=T1G2G1 T1G2G1 20215259 PTHR24205:SF4 FOUR AND A HALF LIM DOMAINS PROTEIN PROTEIN ESPINAS molecular adaptor activity#GO:0060090;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;protein-macromolecule adaptor activity#GO:0030674 supramolecular complex#GO:0099080;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;Z disc#GO:0030018;cellular anatomical entity#GO:0110165;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;contractile fiber#GO:0043292;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;sarcomere#GO:0030017;membrane-bounded organelle#GO:0043227;myofibril#GO:0030016;I band#GO:0031674 transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG175870|UniProtKB=T1F9T0 T1F9T0 20205579 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169668|UniProtKB=T1F276 T1F276 20202926 PTHR21771:SF1 MITOCHONDRIA-EATING PROTEIN-RELATED MITOCHONDRIA-EATING PROTEIN macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;autophagy of mitochondrion#GO:0000422;cellular process#GO:0009987;organelle disassembly#GO:1903008;primary metabolic process#GO:0044238;process utilizing autophagic mechanism#GO:0061919;cellular component organization or biogenesis#GO:0071840;cellular component disassembly#GO:0022411;organelle organization#GO:0006996;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;mitochondrion organization#GO:0007005;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;autophagy#GO:0006914;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248 envelope#GO:0031975;bounding membrane of organelle#GO:0098588;mitochondrial membrane#GO:0031966;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867 HELRO|EnsemblGenome=HelroG138584|UniProtKB=T1EIV8 T1EIV8 20196508 PTHR12547:SF18 CCCH ZINC FINGER/TIS11-RELATED PROTEIN TIS11 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG159663|UniProtKB=T1EPA4 T1EPA4 20198404 PTHR37474:SF1 RNA LIGASE/CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 2'-5' RNA LIGASE FAMILY PROTEIN HELRO|EnsemblGenome=HelroG182643|UniProtKB=T1FIJ1 T1FIJ1 20208640 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG72057|UniProtKB=T1G0U7 T1G0U7 20214695 PTHR24637:SF422 COLLAGEN COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG132012|UniProtKB=T1EHX0 T1EHX0 20196170 PTHR48033:SF17 RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN RRM DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG168380|UniProtKB=T1F0I5 T1F0I5 20202335 PTHR46652:SF8 LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED LEUCINE RICH REPEAT CONTAINING 23 HELRO|EnsemblGenome=HelroG176029|UniProtKB=T1FA19 T1FA19 20205668 PTHR24320:SF226 RETINOL DEHYDROGENASE RETINOL DEHYDROGENASE 11 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG159850|UniProtKB=T1EPH0 T1EPH0 20198470 PTHR24241:SF76 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR NEUROPEPTIDE SIFAMIDE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;binding#GO:0005488;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888;amide binding#GO:0033218 response to organic substance#GO:0010033;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;response to hormone#GO:0009725;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG188719|UniProtKB=T1FQA6 T1FQA6 20211003 PTHR23352:SF2 NEURAL PROLIFERATION DIFFERENTIATION AND CONTROL PROTEIN-1 NPDC-1 PROTEIN NEURAL PROLIFERATION DIFFERENTIATION AND CONTROL PROTEIN 1 HELRO|EnsemblGenome=HelroG163690|UniProtKB=T1EUC9 T1EUC9 20200179 PTHR12011:SF347 ADHESION G-PROTEIN COUPLED RECEPTOR FI21270P1-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG87016|UniProtKB=T1G6K6 T1G6K6 20216703 PTHR23289:SF2 CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG chaperone#PC00072 Vitamin D metabolism and pathway#P04396>FDX#P04607 HELRO|EnsemblGenome=HelroG75318|UniProtKB=T1G236 T1G236 20215134 PTHR24033:SF224 EGF-LIKE DOMAIN-CONTAINING PROTEIN C-TYPE LECTIN HELRO|EnsemblGenome=HelroG180412|UniProtKB=T1FFW5 T1FFW5 20207714 PTHR18945:SF865 NEUROTRANSMITTER GATED ION CHANNEL NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA7, ISOFORM E ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG178574|UniProtKB=T1FDE7 T1FDE7 20206846 PTHR15572:SF0 GLIOMA TUMOR SUPPRESSOR CANDIDATE REGION GENE 1 GLUTAMINE-RICH PROTEIN-RELATED positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;ATPase complex#GO:1904949;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;SWI/SNF complex#GO:0016514;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG159649|UniProtKB=T1EPA0 T1EPA0 20198400 PTHR12608:SF1 TRANSMEMBRANE PROTEIN HTP-1 RELATED TRANSMEMBRANE PROTEIN 165 inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;inorganic cation transmembrane transporter activity#GO:0022890;metal ion transmembrane transporter activity#GO:0046873 HELRO|EnsemblGenome=HelroG181546|UniProtKB=T1FH33 T1FH33 20208132 PTHR28573:SF1 SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 1 SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 1 cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 regulation of biological process#GO:0050789;regulation of microtubule-based process#GO:0032886;regulation of cytoskeleton organization#GO:0051493;cell division#GO:0051301;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;regulation of organelle organization#GO:0033043;regulation of microtubule cytoskeleton organization#GO:0070507;biological regulation#GO:0065007;cell cycle process#GO:0022402;cell cycle#GO:0007049;regulation of cellular component organization#GO:0051128;regulation of microtubule polymerization or depolymerization#GO:0031110;cellular process#GO:0009987;chromosome segregation#GO:0007059 supramolecular complex#GO:0099080;outer kinetochore#GO:0000940;spindle microtubule#GO:0005876;kinetochore#GO:0000776;condensed chromosome, centromeric region#GO:0000779;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;mitotic spindle#GO:0072686;chromosome#GO:0005694;microtubule cytoskeleton#GO:0015630;chromosomal region#GO:0098687;cytoskeleton#GO:0005856;spindle#GO:0005819;microtubule#GO:0005874 HELRO|EnsemblGenome=HelroG102505|UniProtKB=T1ED99 T1ED99 20194551 PTHR20856:SF7 DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;RNA polymerase activity#GO:0097747;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG83299|UniProtKB=T1G538 T1G538 20216186 PTHR46485:SF4 LIM DOMAIN KINASE 1 LIM DOMAIN KINASE 1 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;organelle organization#GO:0006996 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG158762|UniProtKB=T1EN83 T1EN83 20198033 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG63586|UniProtKB=T1FXH8 T1FXH8 20213526 PTHR10516:SF443 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FK506-BINDING PROTEIN 59-RELATED chaperone#PC00072 TGF-beta signaling pathway#P00052>FKBP12#P01288 HELRO|EnsemblGenome=HelroG168159|UniProtKB=T1F088 T1F088 20202238 PTHR13578:SF20 ADDITIONAL SEX COMBS LIKE PROTEIN ASXL POLYCOMB PROTEIN ASX protein-containing complex binding#GO:0044877;binding#GO:0005488;chromatin binding#GO:0003682 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;animal organ development#GO:0048513;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;anatomical structure morphogenesis#GO:0009653;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;regulation of DNA-templated transcription#GO:0006355;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;biological regulation#GO:0065007;animal organ morphogenesis#GO:0009887;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 PcG protein complex#GO:0031519;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG189875|UniProtKB=T1FRF8 T1FRF8 20211405 PTHR24110:SF3 CENTROSOMAL PROTEIN OF 78 KDA CENTROSOMAL PROTEIN OF 78 KDA HELRO|EnsemblGenome=HelroG172724|UniProtKB=T1F5U9 T1F5U9 20204198 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG194308|UniProtKB=T1FVX0 T1FVX0 20212966 PTHR46531:SF1 ZINC TRANSPORTER 6 ZINC TRANSPORTER 6 localization#GO:0051179;monoatomic cation transport#GO:0006812;transition metal ion transport#GO:0000041;metal ion transport#GO:0030001;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transport#GO:0006810 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG117069|UniProtKB=T1EGJ9 T1EGJ9 20213286 PTHR12538:SF0 40S RIBOSOMAL PROTEIN S26 40S RIBOSOMAL PROTEIN S26 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;small ribosomal subunit#GO:0015935;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG113810|UniProtKB=T1EFX0 T1EFX0 20195472 PTHR19134:SF531 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE LAR hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG160031|UniProtKB=T1EPP2 T1EPP2 20198542 PTHR24104:SF50 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG156657|UniProtKB=T1ELZ4 T1ELZ4 20197594 PTHR15653:SF0 STRIATIN CONNECTOR OF KINASE TO AP-1, ISOFORM E HELRO|EnsemblGenome=HelroG82278|UniProtKB=T1G4Q0 T1G4Q0 20216048 PTHR14017:SF1 LYSINE-SPECIFIC DEMETHYLASE LD02225P cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;chromatin DNA binding#GO:0031490;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;protein-containing complex binding#GO:0044877 regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG192354|UniProtKB=T1FTU8 T1FTU8 20212245 PTHR24214:SF38 PDZ AND LIM DOMAIN PROTEIN ZASP PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG74285|UniProtKB=T1G1P3 T1G1P3 20214991 PTHR23431:SF3 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 5'-3' RNA polymerase activity#GO:0034062;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;zinc ion binding#GO:0008270;transition metal ion binding#GO:0046914;nucleotidyltransferase activity#GO:0016779;RNA polymerase activity#GO:0097747;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;metal ion binding#GO:0046872;catalytic activity, acting on RNA#GO:0140098;cation binding#GO:0043169;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;transferase activity#GO:0016740;ion binding#GO:0043167 DNA metabolism protein#PC00009 Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388 HELRO|EnsemblGenome=HelroG193201|UniProtKB=T1FUQ9 T1FUQ9 20212555 PTHR20961:SF38 GLYCOSYLTRANSFERASE PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2 transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG128607|UniProtKB=T1EHP0 T1EHP0 20196090 PTHR13639:SF2 CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL chaperone#PC00072 HELRO|EnsemblGenome=HelroG186188|UniProtKB=T1FNS4 T1FNS4 20210471 PTHR13609:SF4 UBIQUITIN DOMAIN CONTAINING 1 PROTEIN-RELATED RE42193P ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG181719|UniProtKB=T1FH92 T1FH92 20208191 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG62089|UniProtKB=T1FWV5 T1FWV5 20213303 PTHR31296:SF1 UPF0565 PROTEIN C2ORF69 MITOCHONDRIAL PROTEIN C2ORF69 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG188929|UniProtKB=T1FQH6 T1FQH6 20211073 PTHR10378:SF19 LIM DOMAIN-BINDING PROTEIN CHIP, ISOFORM B positive regulation of nitrogen compound metabolic process#GO:0051173;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of RNA metabolic process#GO:0051253;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of transcription by RNA polymerase II#GO:0000122;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;regulation of DNA-templated transcription#GO:0006355;negative regulation of metabolic process#GO:0009892;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG101569|UniProtKB=T1ED55 T1ED55 20194507 PTHR24366:SF170 IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS RE50361P cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG164048|UniProtKB=T1EUT8 T1EUT8 20200338 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161768|UniProtKB=T1ERW0 T1ERW0 20199310 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG168291|UniProtKB=T1F0E7 T1F0E7 20202297 PTHR15453:SF8 TUMOR SUPPRESSOR CANDIDATE 2 TUMOR SUPPRESSOR CANDIDATE 2 biological regulation#GO:0065007;regulation of biological quality#GO:0065008;regulation of membrane potential#GO:0042391 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG179428|UniProtKB=T1FEP3 T1FEP3 20207292 PTHR25462:SF291 BONUS, ISOFORM C-RELATED E3 UBIQUITIN-PROTEIN LIGASE TRIM45 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG75623|UniProtKB=T1G276 T1G276 20215174 PTHR13360:SF1 ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1 ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG79994|UniProtKB=T1G3W2 T1G3W2 20215760 PTHR12566:SF12 CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB TRANSLATIONAL REGULATOR ORB2 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;translation regulator activity#GO:0045182;binding#GO:0005488;organic cyclic compound binding#GO:0097159;ribonucleoprotein complex binding#GO:0043021;ribosome binding#GO:0043022;mRNA binding#GO:0003729;protein-containing complex binding#GO:0044877;translation regulator activity, nucleic acid binding#GO:0090079;translation factor activity, RNA binding#GO:0008135;mRNA 3'-UTR binding#GO:0003730 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of protein metabolic process#GO:0051246;negative regulation of biosynthetic process#GO:0009890;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of translation#GO:0017148;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;synapse#GO:0045202;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;neuron projection#GO:0043005;cell junction#GO:0030054;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG171496|UniProtKB=T1F4C8 T1F4C8 20203677 PTHR44298:SF1 DNAJ HOMOLOG SUBFAMILY B MEMBER 11 DNAJ HOMOLOG SUBFAMILY B MEMBER 11 chaperone#PC00072 HELRO|EnsemblGenome=HelroG155831|UniProtKB=T1ELN1 T1ELN1 20197481 PTHR21663:SF0 HYPOTHETICAL HEAT DOMAIN-CONTAINING HEAT REPEAT-CONTAINING PROTEIN 5B HELRO|EnsemblGenome=HelroG171307|UniProtKB=T1F428 T1F428 20203577 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG92410|UniProtKB=T1G8F8 T1G8F8 20217355 PTHR45636:SF49 PAIRED BOX PROTEIN PAX-6-RELATED-RELATED PAIRED BOX PROTEIN 3 HOMOLOG sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG162392|UniProtKB=T1ESL5 T1ESL5 20199565 PTHR24126:SF14 ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED ANK_REP_REGION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG81871|UniProtKB=T1G4J9 T1G4J9 20215997 PTHR15458:SF5 PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG175281|UniProtKB=T1F938 T1F938 20205337 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG63192|UniProtKB=T1FXB9 T1FXB9 20213467 PTHR13697:SF4 PHOSPHOFRUCTOKINASE ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;phosphotransferase activity, alcohol group as acceptor#GO:0016773;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;carbohydrate kinase activity#GO:0019200;carbohydrate binding#GO:0030246;kinase activity#GO:0016301;cation binding#GO:0043169;transferase activity#GO:0016740;organic cyclic compound binding#GO:0097159;identical protein binding#GO:0042802;nucleoside phosphate binding#GO:1901265;protein binding#GO:0005515;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;ATP binding#GO:0005524;monosaccharide binding#GO:0048029 ribonucleoside triphosphate metabolic process#GO:0009199;nucleoside triphosphate metabolic process#GO:0009141;heterocycle catabolic process#GO:0046700;ribonucleotide catabolic process#GO:0009261;pyridine nucleotide metabolic process#GO:0019362;nucleobase-containing compound metabolic process#GO:0006139;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;purine ribonucleotide catabolic process#GO:0009154;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;oxoacid metabolic process#GO:0043436;nucleoside phosphate catabolic process#GO:1901292;carbohydrate derivative catabolic process#GO:1901136;purine ribonucleoside triphosphate metabolic process#GO:0009205;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;nucleotide catabolic process#GO:0009166;cellular nitrogen compound metabolic process#GO:0034641;nicotinamide nucleotide metabolic process#GO:0046496;nucleoside diphosphate catabolic process#GO:0009134;organic acid metabolic process#GO:0006082;ribonucleotide metabolic process#GO:0009259;monocarboxylic acid metabolic process#GO:0032787;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;organophosphate catabolic process#GO:0046434;small molecule catabolic process#GO:0044282;glycolytic process#GO:0006096;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;nucleotide metabolic process#GO:0009117;small molecule metabolic process#GO:0044281;cellular aromatic compound metabolic process#GO:0006725;monosaccharide metabolic process#GO:0005996;carbohydrate derivative metabolic process#GO:1901135;organonitrogen compound catabolic process#GO:1901565;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;purine-containing compound catabolic process#GO:0072523;cellular nitrogen compound catabolic process#GO:0044270;purine nucleotide catabolic process#GO:0006195;organic cyclic compound metabolic process#GO:1901360;carbohydrate catabolic process#GO:0016052;nucleoside diphosphate metabolic process#GO:0009132;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carbohydrate metabolic process#GO:0005975;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;heterocycle metabolic process#GO:0046483;organonitrogen compound metabolic process#GO:1901564;cellular process#GO:0009987;glucose metabolic process#GO:0006006;aromatic compound catabolic process#GO:0019439;organic cyclic compound catabolic process#GO:1901361;purine nucleoside triphosphate metabolic process#GO:0009144;hexose metabolic process#GO:0019318;carboxylic acid metabolic process#GO:0019752;nucleobase-containing small molecule metabolic process#GO:0055086 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695 carbohydrate kinase#PC00065 Glycolysis#P00024>Phosphofructokinase-1#P00672 HELRO|EnsemblGenome=HelroG165806|UniProtKB=T1EXB0 T1EXB0 20201210 PTHR13140:SF729 MYOSIN UNCONVENTIONAL MYOSIN-IE microfilament motor activity#GO:0000146;cytoskeletal protein binding#GO:0008092;ATP-dependent activity#GO:0140657;binding#GO:0005488;actin filament binding#GO:0051015;cytoskeletal motor activity#GO:0003774;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779 localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;establishment of localization#GO:0051234;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;transport#GO:0006810;endocytosis#GO:0006897;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;import into cell#GO:0098657 microvillus#GO:0005902;actin-based cell projection#GO:0098858;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cell projection#GO:0042995;plasma membrane#GO:0005886 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG126271|UniProtKB=T1EH90 T1EH90 20195940 PTHR23235:SF158 KRUEPPEL-LIKE TRANSCRIPTION FACTOR C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG168769|UniProtKB=T1F0Y1 T1F0Y1 20202481 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG193631|UniProtKB=T1FV76 T1FV76 20212722 PTHR45769:SF3 ADENOSINE KINASE ADENOSINE KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;purine nucleobase metabolic process#GO:0006144;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase metabolic process#GO:0009112;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG188636|UniProtKB=T1FQ73 T1FQ73 20210970 PTHR19282:SF544 TETRASPANIN TETRASPANIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG167014|UniProtKB=T1EYW5 T1EYW5 20201765 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184640|UniProtKB=T1FLN2 T1FLN2 20209731 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166106|UniProtKB=T1EXR8 T1EXR8 20201368 PTHR44755:SF10 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide hormone binding#GO:0017046;hormone binding#GO:0042562;binding#GO:0005488;peptide binding#GO:0042277;amide binding#GO:0033218 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG192684|UniProtKB=T1FU68 T1FU68 20212364 PTHR11652:SF14 30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER SMALL RIBOSOMAL SUBUNIT PROTEIN US12 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;cytosol#GO:0005829;small ribosomal subunit#GO:0015935;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG192686|UniProtKB=T1FU70 T1FU70 20212366 PTHR13217:SF11 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 5 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052;Rho protein signal transduction#GO:0007266 HELRO|EnsemblGenome=HelroG81961|UniProtKB=T1G4L0 T1G4L0 20216008 PTHR13276:SF0 GUANINE NUCLEOTIDE EXCHANGE FACTOR MSS4 GUANINE NUCLEOTIDE EXCHANGE FACTOR MSS4 cation binding#GO:0043169;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;small molecule binding#GO:0036094;binding#GO:0005488;zinc ion binding#GO:0008270;molecular function regulator activity#GO:0098772;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;ion binding#GO:0043167;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;Golgi vesicle transport#GO:0048193;post-Golgi vesicle-mediated transport#GO:0006892;transport#GO:0006810 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG182087|UniProtKB=T1FHQ1 T1FHQ1 20208350 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG174783|UniProtKB=T1F8G9 T1F8G9 20205118 PTHR19282:SF507 TETRASPANIN TETRASPANIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG170127|UniProtKB=T1F2P2 T1F2P2 20203091 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED FMRFAMIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG185127|UniProtKB=T1FMF5 T1FMF5 20210004 PTHR45810:SF9 HISTONE H3.2 HISTONE H3 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG69957|UniProtKB=T1G005 T1G005 20214403 PTHR46374:SF1 PROTEIN CBG07384 START DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171696|UniProtKB=T1F4K3 T1F4K3 20203752 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG187943|UniProtKB=T1FPH6 T1FPH6 20210723 PTHR46024:SF1 HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG113615|UniProtKB=T1EFU2 T1EFU2 20195444 PTHR13501:SF8 CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;large ribosomal subunit#GO:0015934;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG163248|UniProtKB=T1ETU2 T1ETU2 20199992 PTHR25462:SF305 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG108236|UniProtKB=T1EEH5 T1EEH5 20194977 PTHR10741:SF2 TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X TRANSLIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG173646|UniProtKB=T1F731 T1F731 20204630 PTHR10836:SF76 GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED dehydrogenase#PC00092;oxidoreductase#PC00176 Glycolysis#P00024>Glyceraldehyde 3-phosphate dehydrogenase#P00676;Huntington disease#P00029>GAPDH#P00810 HELRO|EnsemblGenome=HelroG157741|UniProtKB=T1EMF2 T1EMF2 20197752 PTHR24073:SF352 DRAB5-RELATED RAS-RELATED PROTEIN RAB6 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 endosomal transport#GO:0016197;cellular localization#GO:0051641;intra-Golgi vesicle-mediated transport#GO:0006891;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;cytosolic transport#GO:0016482;establishment of protein localization#GO:0045184;retrograde transport, endosome to Golgi#GO:0042147;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG166256|UniProtKB=T1EXY4 T1EXY4 20201434 PTHR24104:SF57 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED BEE-MILK PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG173674|UniProtKB=T1F739 T1F739 20204638 PTHR47020:SF1 HILLARIN HILLARIN HELRO|EnsemblGenome=HelroG72187|UniProtKB=T1G0X0 T1G0X0 20214718 PTHR20844:SF0 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 9 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 9 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mediator complex#GO:0016592;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG174886|UniProtKB=T1F8K7 T1F8K7 20205156 PTHR12707:SF0 PINN PININ ribonucleoprotein complex#GO:1990904;catalytic step 2 spliceosome#GO:0071013;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG84094|UniProtKB=T1G5E6 T1G5E6 20216293 PTHR10381:SF11 ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL serine-type endopeptidase activity#GO:0004252;ATP-dependent activity#GO:0140657;binding#GO:0005488;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;enzyme binding#GO:0019899;protein binding#GO:0005515;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175 macromolecule catabolic process#GO:0009057;protein quality control for misfolded or incompletely synthesized proteins#GO:0006515;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;catabolic process#GO:0009056;organonitrogen compound catabolic process#GO:1901565;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein-containing complex#GO:0032991;catalytic complex#GO:1902494 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG89741|UniProtKB=T1G7H0 T1G7H0 20217017 PTHR13009:SF22 HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1 LD43819P molecular function activator activity#GO:0140677;ATPase activator activity#GO:0001671;molecular function regulator activity#GO:0098772 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;positive regulation of molecular function#GO:0044093;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;regulation of molecular function#GO:0065009;biological regulation#GO:0065007;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG159200|UniProtKB=T1ENQ6 T1ENQ6 20198206 PTHR11905:SF159 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG108230|UniProtKB=T1EEH3 T1EEH3 20194975 PTHR44027:SF7 DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG chaperone#PC00072 HELRO|EnsemblGenome=HelroG125141|UniProtKB=T1EH45 T1EH45 20195895 PTHR13281:SF0 TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;protein-containing complex assembly#GO:0065003;mitochondrial proton-transporting ATP synthase complex assembly#GO:0033615;cellular component organization#GO:0016043;mitochondrion organization#GO:0007005;cellular process#GO:0009987 envelope#GO:0031975;cytoplasm#GO:0005737;mitochondrial membrane#GO:0031966;intracellular membrane-bounded organelle#GO:0043231;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG188329|UniProtKB=T1FPW1 T1FPW1 20210858 PTHR11636:SF89 POU DOMAIN POU DOMAIN PROTEIN 2, ISOFORM B-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG166001|UniProtKB=T1EXK3 T1EXK3 20201303 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177337|UniProtKB=T1FBJ0 T1FBJ0 20206189 PTHR45784:SF5 C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED HELRO|EnsemblGenome=HelroG193602|UniProtKB=T1FV60 T1FV60 20212706 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG193700|UniProtKB=T1FV99 T1FV99 20212745 PTHR22969:SF15 IKB KINASE FI05319P transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;peptidyl-amino acid modification#GO:0018193;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;nitrogen compound metabolic process#GO:0006807;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG125444|UniProtKB=T1EH60 T1EH60 20195910 PTHR11839:SF15 UDP/ADP-SUGAR PYROPHOSPHATASE URIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHATASE NUDT14 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;carbohydrate derivative metabolic process#GO:1901135;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;organophosphate metabolic process#GO:0019637;nucleobase-containing small molecule metabolic process#GO:0055086;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152 pyrophosphatase#PC00196 HELRO|EnsemblGenome=HelroG167274|UniProtKB=T1EZ76 T1EZ76 20201876 PTHR21552:SF2 ADULT RETINA PROTEIN CREB3 REGULATORY FACTOR sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG190994|UniProtKB=T1FSH4 T1FSH4 20211771 PTHR46394:SF1 ANNEXIN PNPLA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182640|UniProtKB=T1FIJ0 T1FIJ0 20208639 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170118|UniProtKB=T1F2N7 T1F2N7 20203086 PTHR36191:SF1 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177311|UniProtKB=T1FBH5 T1FBH5 20206174 PTHR24390:SF148 ZINC FINGER PROTEIN CTCF sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG188596|UniProtKB=T1FQ57 T1FQ57 20210954 PTHR21780:SF0 TRANSMEMBRANE PROTEIN 209 TRANSMEMBRANE PROTEIN 209 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG158749|UniProtKB=T1EN72 T1EN72 20198022 PTHR21501:SF1 PROTEIN FAM-161 PROTEIN FAM-161 cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;cellular component organization#GO:0016043;cellular process#GO:0009987;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;organelle organization#GO:0006996 membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cilium#GO:0005929;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG171464|UniProtKB=T1F4B4 T1F4B4 20203663 PTHR46469:SF1 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;transcription initiation at RNA polymerase II promoter#GO:0006367;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nucleobase-containing compound biosynthetic process#GO:0034654;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;transcription factor TFIID complex#GO:0005669;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase II, holoenzyme#GO:0016591;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 General transcription by RNA polymerase I#P00022>TAF-IA#P00651;General transcription by RNA polymerase I#P00022>SL1 complex#P00653;General transcription by RNA polymerase I#P00022>TAF-IB#P00650;General transcription regulation#P00023>TBP-associated factors#P00658;Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385;General transcription by RNA polymerase I#P00022>TAF-IC#P00649 HELRO|EnsemblGenome=HelroG70893|UniProtKB=T1G0D8 T1G0D8 20214536 PTHR12378:SF80 DESUMOYLATING ISOPEPTIDASE IP06716P-RELATED hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG91068|UniProtKB=T1G7Z3 T1G7Z3 20217190 PTHR48021:SF1 FAMILY NOT NAMED GH07001P-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG185989|UniProtKB=T1FNI9 T1FNI9 20210386 PTHR31804:SF3 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15 HELRO|EnsemblGenome=HelroG116835|UniProtKB=T1EGI2 T1EGI2 20195684 PTHR43920:SF5 CHLORIDE INTRACELLULAR CHANNEL, ISOFORM A CHLORIDE INTRACELLULAR CHANNEL CLIC inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216 localization#GO:0051179;chloride transport#GO:0006821;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;inorganic anion transport#GO:0015698;monoatomic anion transport#GO:0006820;transport#GO:0006810 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG191126|UniProtKB=T1FSM3 T1FSM3 20211820 PTHR10133:SF62 DNA POLYMERASE I DNA POLYMERASE THETA DNA-directed DNA polymerase activity#GO:0003887;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on DNA#GO:0140097;DNA polymerase activity#GO:0034061 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;DNA damage response#GO:0006974;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 DNA-directed DNA polymerase#PC00018;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG104208|UniProtKB=T1EDK4 T1EDK4 20194656 PTHR24057:SF0 GLYCOGEN SYNTHASE KINASE-3 ALPHA PROTEIN KINASE SHAGGY-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;developmental process#GO:0032502;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cell differentiation#GO:0030154;peptidyl-threonine phosphorylation#GO:0018107;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Glycogen Synthase Kinase-3Beta#P01441;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>GSK-3#P00902;PI3 kinase pathway#P00048>GSK3#P01181;Interleukin signaling pathway#P00036>GSK3#P00976;Ras Pathway#P04393>GSK3#P04546;Angiogenesis#P00005>GSK3beta#P00211;Alzheimer disease-presenilin pathway#P00004>GSK-3beta#P00175;PDGF signaling pathway#P00047>GSK3#P01153 HELRO|EnsemblGenome=HelroG180451|UniProtKB=T1FFX9 T1FFX9 20207728 PTHR12515:SF5 STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED PROTEIN SMAUG RNA binding#GO:0003723;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 negative regulation of gene expression#GO:0010629;regulation of catabolic process#GO:0009894;heterocycle catabolic process#GO:0046700;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;nucleobase-containing compound metabolic process#GO:0006139;RNA destabilization#GO:0050779;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;regulation of biological quality#GO:0065008;nitrogen compound metabolic process#GO:0006807;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;positive regulation of mRNA catabolic process#GO:0061014;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of catabolic process#GO:0009896;mRNA destabilization#GO:0061157;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323;positive regulation of nitrogen compound metabolic process#GO:0051173;cellular aromatic compound metabolic process#GO:0006725;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;RNA metabolic process#GO:0016070;positive regulation of cellular catabolic process#GO:0031331;cellular nitrogen compound catabolic process#GO:0044270;organic cyclic compound metabolic process#GO:1901360;positive regulation of metabolic process#GO:0009893;mRNA catabolic process#GO:0006402;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;positive regulation of mRNA metabolic process#GO:1903313;heterocycle metabolic process#GO:0046483;negative regulation of biosynthetic process#GO:0009890;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of cellular catabolic process#GO:0031329;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;positive regulation of RNA metabolic process#GO:0051254 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;P-body#GO:0000932;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic ribonucleoprotein granule#GO:0036464 HELRO|EnsemblGenome=HelroG84068|UniProtKB=T1G5E2 T1G5E2 20216289 PTHR11849:SF191 ETS ECDYSONE-INDUCED PROTEIN 74EF ISOFORM B transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 PDGF signaling pathway#P00047>Ets#P01167 HELRO|EnsemblGenome=HelroG178091|UniProtKB=T1FCQ2 T1FCQ2 20206601 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG71735|UniProtKB=T1G0R0 T1G0R0 20214658 PTHR11080:SF2 PYRAZINAMIDASE/NICOTINAMIDASE LD05707P HELRO|EnsemblGenome=HelroG182758|UniProtKB=T1FIP3 T1FIP3 20208692 PTHR12027:SF101 WNT RELATED PROTEIN WNT-4 molecular function activator activity#GO:0140677;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;protein binding#GO:0005515;cytokine activity#GO:0005125;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;neurogenesis#GO:0022008;developmental process#GO:0032502;multicellular organism development#GO:0007275;cell communication#GO:0007154;cell fate commitment#GO:0045165;cell-cell signaling by wnt#GO:0198738;nervous system development#GO:0007399;cellular process#GO:0009987;regulation of biological process#GO:0050789;system development#GO:0048731;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;cell-cell signaling#GO:0007267;signaling#GO:0023052;canonical Wnt signaling pathway#GO:0060070;Wnt signaling pathway#GO:0016055 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Cadherin signaling pathway#P00012>Wnt#P00474 HELRO|EnsemblGenome=HelroG108598|UniProtKB=T1EEK7 T1EEK7 20195009 PTHR48012:SF10 STERILE20-LIKE KINASE, ISOFORM B-RELATED FI20177P1 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG122299|UniProtKB=T1EGU4 T1EGU4 20195794 PTHR24229:SF40 NEUROPEPTIDES RECEPTOR ALLATOSTATIN C RECEPTOR 1-RELATED G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HELRO|EnsemblGenome=HelroG63395|UniProtKB=T1FXF4 T1FXF4 20213502 PTHR42679:SF2 S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;pentosyltransferase activity#GO:0016763;catalytic activity#GO:0003824 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;sulfur compound metabolic process#GO:0006790;proteinogenic amino acid biosynthetic process#GO:0170038;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;aspartate family amino acid biosynthetic process#GO:0009067;alpha-amino acid biosynthetic process#GO:1901607;nitrogen compound metabolic process#GO:0006807;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;aspartate family amino acid metabolic process#GO:0009066;small molecule biosynthetic process#GO:0044283;L-amino acid biosynthetic process#GO:0170034;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 nucleotide kinase#PC00172 Purine metabolism#P02769>Nucleoside Phosphorylase#P03115 HELRO|EnsemblGenome=HelroG177733|UniProtKB=T1FC56 T1FC56 20206405 PTHR23309:SF49 3-HYDROXYACYL-COA DEHYROGENASE PEROXISOMAL BIFUNCTIONAL ENZYME oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;lipid oxidation#GO:0034440;cellular metabolic process#GO:0044237;lipid catabolic process#GO:0016042;lipid modification#GO:0030258;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;fatty acid catabolic process#GO:0009062;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;fatty acid metabolic process#GO:0006631;small molecule catabolic process#GO:0044282;fatty acid beta-oxidation#GO:0006635;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;carboxylic acid metabolic process#GO:0019752;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG185184|UniProtKB=T1FMH4 T1FMH4 20210023 PTHR12027:SF102 WNT RELATED PROTEIN WNT molecular function activator activity#GO:0140677;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;protein binding#GO:0005515;cytokine activity#GO:0005125;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;neurogenesis#GO:0022008;developmental process#GO:0032502;multicellular organism development#GO:0007275;cell communication#GO:0007154;cell fate commitment#GO:0045165;cell-cell signaling by wnt#GO:0198738;nervous system development#GO:0007399;cellular process#GO:0009987;regulation of biological process#GO:0050789;system development#GO:0048731;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;cell-cell signaling#GO:0007267;signaling#GO:0023052;canonical Wnt signaling pathway#GO:0060070;Wnt signaling pathway#GO:0016055 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Cadherin signaling pathway#P00012>Wnt#P00474 HELRO|EnsemblGenome=HelroG187955|UniProtKB=T1FPI2 T1FPI2 20210729 PTHR13523:SF2 COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77 COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED cellular component organization or biogenesis#GO:0071840;mitochondrion organization#GO:0007005;cellular component organization#GO:0016043;cellular process#GO:0009987;organelle organization#GO:0006996 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG189106|UniProtKB=T1FQN7 T1FQN7 20211134 PTHR24399:SF23 ZINC FINGER AND BTB DOMAIN-CONTAINING C2H2-TYPE DOMAIN-CONTAINING PROTEIN cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription repressor activity#GO:0001217;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG190472|UniProtKB=T1FS05 T1FS05 20211602 PTHR24023:SF1097 COLLAGEN ALPHA COLLAGEN ALPHA-1(VII) CHAIN ISOFORM X1 structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG82169|UniProtKB=T1G4N8 T1G4N8 20216036 PTHR31488:SF1 DPY-19-LIKE 1, LIKE (H. SAPIENS) C-MANNOSYLTRANSFERASE DPY19L1 mannosyltransferase activity#GO:0000030;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein mannosylation#GO:0035268;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085;mannosylation#GO:0097502 envelope#GO:0031975;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;organelle membrane#GO:0031090;organelle inner membrane#GO:0019866;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;nuclear membrane#GO:0031965;endomembrane system#GO:0012505;nuclear inner membrane#GO:0005637;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG176604|UniProtKB=T1FAQ0 T1FAQ0 20205899 PTHR43670:SF61 HEAT SHOCK PROTEIN 26 C-CAP_COFACTOR C-LIKE DOMAIN-CONTAINING PROTEIN chaperone#PC00072 HELRO|EnsemblGenome=HelroG193493|UniProtKB=T1FV18 T1FV18 20212664 PTHR45818:SF3 PROTEIN VAV PROTEIN VAV nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;regulation of GTPase activity#GO:0043087;regulation of molecular function#GO:0065009 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 PDGF signaling pathway#P00047>Vav#P01169 HELRO|EnsemblGenome=HelroG83983|UniProtKB=T1G5C6 T1G5C6 20216273 PTHR14274:SF1 SMALL INTEGRAL MEMBRANE PROTEIN 8 SMALL INTEGRAL MEMBRANE PROTEIN 8 HELRO|EnsemblGenome=HelroG185603|UniProtKB=T1FN10 T1FN10 20210209 PTHR11034:SF56 N-MYC DOWNSTREAM REGULATED GH09802P serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG89643|UniProtKB=T1G7F4 T1G7F4 20217001 PTHR21547:SF0 CLUSTERIN ASSOCIATED PROTEIN 1 CLUSTERIN-ASSOCIATED PROTEIN 1 organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 microtubule organizing center#GO:0005815;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;intraciliary transport particle B#GO:0030992;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cytoskeleton#GO:0005856;cilium#GO:0005929;intraciliary transport particle#GO:0030990 HELRO|EnsemblGenome=HelroG103167|UniProtKB=T1EDE7 T1EDE7 20194599 PTHR14898:SF0 ENHANCER OF POLYCOMB ENHANCER OF POLYCOMB-LIKE PROTEIN regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG192665|UniProtKB=T1FU63 T1FU63 20212359 PTHR12858:SF2 RIBOSOME BIOGENESIS PROTEIN RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG snoRNA binding#GO:0030515;GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;nucleic acid binding#GO:0003676;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;RNA binding#GO:0003723;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;anion binding#GO:0043168;ion binding#GO:0043167 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;ribosome biogenesis#GO:0042254;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274 ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;protein-containing complex#GO:0032991;90S preribosome#GO:0030686 HELRO|EnsemblGenome=HelroG181826|UniProtKB=T1FHD6 T1FHD6 20208235 PTHR15114:SF1 REPLICATION PROTEIN A3 REPLICATION PROTEIN A 14 KDA SUBUNIT damaged DNA binding#GO:0003684;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;single-stranded DNA binding#GO:0003697;DNA binding#GO:0003677 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;nucleotide-excision repair#GO:0006289;cellular response to stimulus#GO:0051716;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;mismatch repair#GO:0006298;base-excision repair#GO:0006284;cellular nitrogen compound metabolic process#GO:0034641;double-strand break repair via homologous recombination#GO:0000724;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;response to stress#GO:0006950;nitrogen compound metabolic process#GO:0006807;recombinational repair#GO:0000725;DNA replication#GO:0006260;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;site of DNA damage#GO:0090734;protein-DNA complex#GO:0032993;replisome#GO:0030894;intracellular organelle lumen#GO:0070013;site of double-strand break#GO:0035861;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nuclear replication fork#GO:0043596;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513;replication fork#GO:0005657 Cell cycle#P00013>Pre-replication Complex#P00478 HELRO|EnsemblGenome=HelroG114208|UniProtKB=T1EG01 T1EG01 20195503 PTHR23503:SF8 SOLUTE CARRIER FAMILY 2 FACILITATED GLUCOSE TRANSPORTER PROTEIN 1 transmembrane transporter activity#GO:0022857;sugar transmembrane transporter activity#GO:0051119;transporter activity#GO:0005215;carbohydrate transmembrane transporter activity#GO:0015144 localization#GO:0051179;organic substance transport#GO:0071702;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;cellular process#GO:0009987;carbohydrate transmembrane transport#GO:0034219;carbohydrate transport#GO:0008643 cellular anatomical entity#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG104422|UniProtKB=T1EDL6 T1EDL6 20194668 PTHR43000:SF7 DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED DTDP-D-GLUCOSE 4,6-DEHYDRATASE dehydratase#PC00091;lyase#PC00144 O-antigen biosynthesis#P02757>dTDP-glucose 4,6-dehydratase#P03045 HELRO|EnsemblGenome=HelroG176799|UniProtKB=T1FAX3 T1FAX3 20205972 PTHR22692:SF26 MYOSIN VII, XV SH3 DOMAIN-CONTAINING PROTEIN actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG112004|UniProtKB=T1EFG3 T1EFG3 20195315 PTHR15591:SF19 RUN AND SH3 DOMAIN CONTAINING RUN DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1 HELRO|EnsemblGenome=HelroG181271|UniProtKB=T1FGT8 T1FGT8 20208037 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178666|UniProtKB=T1FDJ1 T1FDJ1 20206890 PTHR44006:SF1 U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 ribonucleoprotein complex#GO:1990904;catalytic step 2 spliceosome#GO:0071013;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 mRNA splicing#P00058>U5#P01474 HELRO|EnsemblGenome=HelroG74987|UniProtKB=T1G1Z1 T1G1Z1 20215089 PTHR46273:SF4 MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED AT19640P signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG167891|UniProtKB=T1EZX5 T1EZX5 20202125 PTHR13510:SF44 FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED RABENOSYN-5 HELRO|EnsemblGenome=HelroG85509|UniProtKB=T1G5Y2 T1G5Y2 20216479 PTHR10290:SF3 DNA TOPOISOMERASE I DNA TOPOISOMERASE 1 DNA topoisomerase#PC00017 DNA replication#P00017>Top#P00530;DNA replication#P00017>DNA Topisomerase#P00536 HELRO|EnsemblGenome=HelroG191649|UniProtKB=T1FT63 T1FT63 20212010 PTHR47537:SF2 CUBILIN CUBILIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG90768|UniProtKB=T1G7V9 T1G7V9 20217156 PTHR10026:SF8 CYCLIN CYCLIN-H protein kinase regulator activity#GO:0019887;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 regulation of protein kinase activity#GO:0045859;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of catalytic activity#GO:0050790;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of phosphorus metabolic process#GO:0051174;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of molecular function#GO:0065009;regulation of protein phosphorylation#GO:0001932;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;regulation of protein serine/threonine kinase activity#GO:0071900;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cyclin-dependent protein serine/threonine kinase activity#GO:0000079;regulation of kinase activity#GO:0043549;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;serine/threonine protein kinase complex#GO:1902554;RNA polymerase II transcription regulator complex#GO:0090575;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase II, holoenzyme#GO:0016591;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;transcription factor TFIIH holo complex#GO:0005675;nuclear protein-containing complex#GO:0140513 kinase activator#PC00138 HELRO|EnsemblGenome=HelroG136896|UniProtKB=T1EIG4 T1EIG4 20196364 PTHR22593:SF2 TRANSMEMBRANE PROTEIN 18 TRANSMEMBRANE PROTEIN 18 envelope#GO:0031975;nuclear membrane#GO:0031965;endomembrane system#GO:0012505;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG92517|UniProtKB=T1G8I0 T1G8I0 20217377 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190849|UniProtKB=T1FSD1 T1FSD1 20211728 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER FI01427P membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG162671|UniProtKB=T1ET00 T1ET00 20199700 PTHR24244:SF1 NEUROPEPTIDE S RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG186200|UniProtKB=T1FNT2 T1FNT2 20210479 PTHR21737:SF3 POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3 POLYGLUTAMINE-BINDING PROTEIN 1 ribonucleoprotein complex binding#GO:0043021;protein-containing complex binding#GO:0044877;binding#GO:0005488 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;alternative mRNA splicing, via spliceosome#GO:0000380;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear body#GO:0016604;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG101326|UniProtKB=T1ED39 T1ED39 20194492 PTHR12755:SF6 CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;tRNA processing#GO:0008033;RNA processing#GO:0006396;mRNA polyadenylation#GO:0006378;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;mRNA 3'-end processing#GO:0031124;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;tRNA splicing, via endonucleolytic cleavage and ligation#GO:0006388;mRNA processing#GO:0006397;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG191960|UniProtKB=T1FTG3 T1FTG3 20212110 PTHR18934:SF109 ATP-DEPENDENT RNA HELICASE ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640 cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG71944|UniProtKB=T1G0T2 T1G0T2 20214680 PTHR24193:SF121 ANKYRIN REPEAT PROTEIN ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D HELRO|EnsemblGenome=HelroG192879|UniProtKB=T1FUD9 T1FUD9 20212435 PTHR45975:SF2 NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;methylated histone binding#GO:0035064;histone binding#GO:0042393;modification-dependent protein binding#GO:0140030;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;protein binding#GO:0005515 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;ATPase complex#GO:1904949;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG76590|UniProtKB=T1G2L9 T1G2L9 20215317 PTHR10978:SF5 SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL dehydrogenase#PC00092;oxidoreductase#PC00176 TCA cycle#P00051>Succinate Dehydrogenase#P01273 HELRO|EnsemblGenome=HelroG163463|UniProtKB=T1EU31 T1EU31 20200081 PTHR24034:SF209 EGF-LIKE DOMAIN-CONTAINING PROTEIN EGF-LIKE DOMAIN-CONTAINING PROTEIN extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG96655|UniProtKB=T1G9D1 T1G9D1 20217678 PTHR20338:SF8 NUCLEAR RESPIRATORY FACTOR 1 NUCLEAR RESPIRATORY FACTOR 1 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG174119|UniProtKB=T1F7N2 T1F7N2 20204831 PTHR24256:SF470 TRYPTASE-RELATED INACTIVE CLIP DOMAIN-CONTAINING SERINE PROTEASE A30 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG189225|UniProtKB=T1FQT8 T1FQT8 20211185 PTHR14150:SF12 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A membrane-enclosed lumen#GO:0031974;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG174099|UniProtKB=T1F7L6 T1F7L6 20204815 PTHR45080:SF8 CONTACTIN 5 IG-LIKE DOMAIN-CONTAINING PROTEIN cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG190723|UniProtKB=T1FS86 T1FS86 20211683 PTHR43326:SF1 METHIONYL-TRNA SYNTHETASE METHIONINE--TRNA LIGASE, MITOCHONDRIAL catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG113191|UniProtKB=T1EFQ7 T1EFQ7 20195409 PTHR11893:SF36 INNEXIN INNEXIN-5 cell junction protein#PC00070;gap junction#PC00105 HELRO|EnsemblGenome=HelroG165352|UniProtKB=T1EWM4 T1EWM4 20200974 PTHR46880:SF5 RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG113173|UniProtKB=T1EFQ6 T1EFQ6 20195408 PTHR11043:SF0 ZETA-COAT PROTEIN COATOMER SUBUNIT ZETA cellular localization#GO:0051641;intra-Golgi vesicle-mediated transport#GO:0006891;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;vesicle coat#GO:0030120;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;Golgi-associated vesicle membrane#GO:0030660;protein-containing complex#GO:0032991;COPI vesicle coat#GO:0030126;endomembrane system#GO:0012505;membrane coat#GO:0030117;coated vesicle membrane#GO:0030662;COPI-coated vesicle#GO:0030137;Golgi-associated vesicle#GO:0005798;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;coated membrane#GO:0048475;cytoplasmic vesicle membrane#GO:0030659 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG193401|UniProtKB=T1FUY5 T1FUY5 20212631 PTHR12659:SF7 RHO-TYPE GTPASE ACTIVATING PROTEIN CROSSVEINLESS C, ISOFORM C nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of cell communication#GO:0010646;regulation of Rho protein signal transduction#GO:0035023;regulation of signaling#GO:0023051;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of intracellular signal transduction#GO:1902531;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;regulation of cellular process#GO:0050794;organelle organization#GO:0006996;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG185931|UniProtKB=T1FNG2 T1FNG2 20210359 PTHR21433:SF0 TRANSMEMBRANE PROTEIN INDUCED BY TUMOR NECROSIS FACTOR ALPHA TRANSMEMBRANE PROTEIN 120 HOMOLOG cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG84542|UniProtKB=T1G5K1 T1G5K1 20216348 PTHR10196:SF68 SUGAR KINASE GLYCEROL KINASE 5-RELATED transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 organic hydroxy compound metabolic process#GO:1901615;lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;triglyceride metabolic process#GO:0006641;organophosphate biosynthetic process#GO:0090407;cellular metabolic process#GO:0044237;alcohol metabolic process#GO:0006066;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;acylglycerol metabolic process#GO:0006639;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;carbohydrate derivative biosynthetic process#GO:1901137;neutral lipid metabolic process#GO:0006638;glycerolipid metabolic process#GO:0046486;glycerol-3-phosphate metabolic process#GO:0006072;organophosphate metabolic process#GO:0019637;phosphorylation#GO:0016310;cellular lipid metabolic process#GO:0044255;carbohydrate metabolic process#GO:0005975;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 carbohydrate kinase#PC00065 HELRO|EnsemblGenome=HelroG83456|UniProtKB=T1G558 T1G558 20216206 PTHR19444:SF13 UNC-93 RELATED PROTEIN UNC-93 HOMOLOG A membrane-bound signaling molecule#PC00152 HELRO|EnsemblGenome=HelroG156884|UniProtKB=T1EM26 T1EM26 20197626 PTHR24070:SF406 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY SMALL MONOMERIC GTPASE GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 small GTPase#PC00208;G-protein#PC00020 Integrin signalling pathway#P00034>Rap1#P00906 HELRO|EnsemblGenome=HelroG186577|UniProtKB=T1FP13 T1FP13 20210560 PTHR43511:SF4 FAMILY NOT NAMED UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE HELRO|EnsemblGenome=HelroG68581|UniProtKB=T1FZH0 T1FZH0 20214218 PTHR15622:SF2 WD40 REPEAT PROTEIN U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP4 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG188085|UniProtKB=T1FPL9 T1FPL9 20210766 PTHR22957:SF352 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER WHACKED nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;activation of GTPase activity#GO:0090630;biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG132379|UniProtKB=T1EHY2 T1EHY2 20196182 PTHR24240:SF85 OPSIN OPSIN RH1-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;response to light stimulus#GO:0009416;cellular response to stimulus#GO:0051716;detection of stimulus#GO:0051606;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to external stimulus#GO:0009605;regulation of cellular process#GO:0050794;response to radiation#GO:0009314;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;response to abiotic stimulus#GO:0009628;signaling#GO:0023052;cellular response to light stimulus#GO:0071482 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Rhodopsin#P00747 HELRO|EnsemblGenome=HelroG111663|UniProtKB=T1EFD4 T1EFD4 20195286 PTHR15959:SF0 SYNTAXIN-18 SYNTAXIN-18 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;Golgi vesicle transport#GO:0048193;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;transport#GO:0006810 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;SNARE complex#GO:0031201;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034;membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG184705|UniProtKB=T1FLT5 T1FLT5 20209784 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG145322|UniProtKB=T1EJK1 T1EJK1 20196751 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG69010|UniProtKB=T1FZN4 T1FZN4 20214282 PTHR11108:SF1 FERROCHELATASE FERROCHELATASE, MITOCHONDRIAL lyase activity#GO:0016829;catalytic activity#GO:0003824 tetrapyrrole metabolic process#GO:0033013;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;porphyrin-containing compound metabolic process#GO:0006778;cellular biosynthetic process#GO:0044249;pigment metabolic process#GO:0042440;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;heme biosynthetic process#GO:0006783;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;pigment biosynthetic process#GO:0046148;aromatic compound biosynthetic process#GO:0019438;heme metabolic process#GO:0042168;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 lyase#PC00144 Heme biosynthesis#P02746>Ferrochelatase#P02972 HELRO|EnsemblGenome=HelroG77349|UniProtKB=T1G2W7 T1G2W7 20215415 PTHR11920:SF501 GUANYLYL CYCLASE GUANYLATE CYCLASE 32E adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG193090|UniProtKB=T1FUM1 T1FUM1 20212517 PTHR12766:SF7 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DEATH DOMAIN-ASSOCIATED PROTEIN 6 FAS signaling pathway#P00020>DAXX#P00602;Apoptosis signaling pathway#P00006>DAXX#P00296 HELRO|EnsemblGenome=HelroG161475|UniProtKB=T1ERI3 T1ERI3 20199183 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG143063|UniProtKB=T1EJ89 T1EJ89 20196639 PTHR28624:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 51 MITOCHONDRIAL POTASSIUM CHANNEL HELRO|EnsemblGenome=HelroG167026|UniProtKB=T1EYX0 T1EYX0 20201770 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG85985|UniProtKB=T1G656 T1G656 20216553 PTHR32385:SF15 MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1 mannosyltransferase activity#GO:0000030;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;glycosphingolipid biosynthetic process#GO:0006688;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;glycolipid metabolic process#GO:0006664;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;liposaccharide metabolic process#GO:1903509;membrane lipid biosynthetic process#GO:0046467;sphingolipid metabolic process#GO:0006665;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;carbohydrate derivative biosynthetic process#GO:1901137;membrane lipid metabolic process#GO:0006643;nitrogen compound metabolic process#GO:0006807;glycolipid biosynthetic process#GO:0009247;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;sphingolipid biosynthetic process#GO:0030148;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG176919|UniProtKB=T1FB18 T1FB18 20206017 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG106476|UniProtKB=T1EE28 T1EE28 20194830 PTHR10177:SF559 CYCLINS G2_MITOTIC-SPECIFIC CYCLIN-B protein kinase regulator activity#GO:0019887;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 regulation of protein kinase activity#GO:0045859;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;mitotic cell cycle phase transition#GO:0044772;regulation of nitrogen compound metabolic process#GO:0051171;cell cycle process#GO:0022402;regulation of catalytic activity#GO:0050790;cellular process#GO:0009987;cell cycle phase transition#GO:0044770;mitotic cell cycle process#GO:1903047;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;regulation of primary metabolic process#GO:0080090;mitotic cell cycle#GO:0000278;regulation of macromolecule metabolic process#GO:0060255;regulation of molecular function#GO:0065009;regulation of protein phosphorylation#GO:0001932;regulation of cellular process#GO:0050794;regulation of protein serine/threonine kinase activity#GO:0071900;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cyclin-dependent protein serine/threonine kinase activity#GO:0000079;regulation of kinase activity#GO:0043549;regulation of cellular metabolic process#GO:0031323 microtubule organizing center#GO:0005815;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;centrosome#GO:0005813;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856 kinase activator#PC00138 Cell cycle#P00013>Cyclin B#P00486;p53 pathway#P00059>Cyclin B#P04614 HELRO|EnsemblGenome=HelroG193450|UniProtKB=T1FUZ9 T1FUZ9 20212645 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG190787|UniProtKB=T1FSA6 T1FSA6 20211703 PTHR13316:SF0 ZINC FINGER, CCHC DOMAIN CONTAINING 8 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 8 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;catalytic step 2 spliceosome#GO:0071013;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG102359|UniProtKB=T1ED97 T1ED97 20194549 PTHR24115:SF973 KINESIN-RELATED KINESIN MOTOR DOMAIN-CONTAINING PROTEIN pyrophosphatase activity#GO:0016462;cytoskeletal protein binding#GO:0008092;microtubule motor activity#GO:0003777;tubulin binding#GO:0015631;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;cytoskeletal motor activity#GO:0003774;microtubule binding#GO:0008017;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 vesicle transport along microtubule#GO:0047496;cellular localization#GO:0051641;organelle localization#GO:0051640;vesicle localization#GO:0051648;transport#GO:0006810;microtubule-based movement#GO:0007018;cellular process#GO:0009987;transport along microtubule#GO:0010970;localization#GO:0051179;microtubule-based transport#GO:0099111;establishment of localization#GO:0051234;microtubule-based process#GO:0007017;establishment of vesicle localization#GO:0051650;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;organelle transport along microtubule#GO:0072384;establishment of organelle localization#GO:0051656;vesicle cytoskeletal trafficking#GO:0099518 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;microtubule associated complex#GO:0005875;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG157568|UniProtKB=T1EMD2 T1EMD2 20197732 PTHR11652:SF14 30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER SMALL RIBOSOMAL SUBUNIT PROTEIN US12 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;cytosol#GO:0005829;small ribosomal subunit#GO:0015935;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG175213|UniProtKB=T1F908 T1F908 20205307 PTHR31198:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 84 CENTROSOMAL AT-AC SPLICING FACTOR HELRO|EnsemblGenome=HelroG92122|UniProtKB=T1G8C2 T1G8C2 20217319 PTHR46212:SF10 PEFLIN PEFLIN vesicle targeting, to, from or within Golgi#GO:0048199;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;organelle localization#GO:0051640;vesicle localization#GO:0051648;membrane organization#GO:0061024;transport#GO:0006810;protein-containing complex assembly#GO:0065003;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;vesicle targeting#GO:0006903;Golgi vesicle transport#GO:0048193;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;vesicle budding from membrane#GO:0006900;establishment of localization#GO:0051234;organelle organization#GO:0006996;establishment of vesicle localization#GO:0051650;protein-containing complex organization#GO:0043933;COPII-coated vesicle budding#GO:0090114;vesicle organization#GO:0016050;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;establishment of organelle localization#GO:0051656 HELRO|EnsemblGenome=HelroG185900|UniProtKB=T1FNF0 T1FNF0 20210347 PTHR24250:SF27 CHYMOTRYPSIN-RELATED ELASTASE 2 LIKE hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG188123|UniProtKB=T1FPN9 T1FPN9 20210786 PTHR21419:SF30 FAMILY NOT NAMED IG-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG91579|UniProtKB=T1G858 T1G858 20217255 PTHR13169:SF0 UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN UBIQUITIN-LIKE PROTEIN 3 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG72730|UniProtKB=T1G145 T1G145 20214793 PTHR19134:SF559 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE DOMAIN-CONTAINING PROTEIN hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG188891|UniProtKB=T1FQG2 T1FQG2 20211059 PTHR11370:SF5 DNA-REPAIR PROTEIN XRCC1 DNA REPAIR PROTEIN XRCC1 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG173382|UniProtKB=T1F6R1 T1F6R1 20204510 PTHR32026:SF10 METHYLTRANSFERASE-LIKE PROTEIN 24 METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG182907|UniProtKB=T1FIX0 T1FIX0 20208769 PTHR33332:SF48 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG66918|UniProtKB=T1FYS9 T1FYS9 20213977 PTHR13291:SF0 JOSEPHIN 1, 2 JOSEPHIN-LIKE PROTEIN cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG162854|UniProtKB=T1ETA2 T1ETA2 20199802 PTHR47510:SF3 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173256|UniProtKB=T1F6L8 T1F6L8 20204467 PTHR31516:SF17 STABILIZER OF AXONEMAL MICROTUBULES 2 STABILIZER OF AXONEMAL MICROTUBULES 2 cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;microtubule binding#GO:0008017;tubulin binding#GO:0015631;binding#GO:0005488 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG156650|UniProtKB=T1ELZ3 T1ELZ3 20197593 PTHR11002:SF76 CARBONIC ANHYDRASE CARBONIC ANHYDRASE dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG160182|UniProtKB=T1EPX8 T1EPX8 20198628 PTHR21397:SF2 CHROMATIN COMPLEXES SUBUNIT BAP18-RELATED CHROMATIN COMPLEXES SUBUNIT BAP18 membrane-enclosed lumen#GO:0031974;histone methyltransferase complex#GO:0035097;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;chromatin#GO:0000785;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;methyltransferase complex#GO:0034708;SWI/SNF superfamily-type complex#GO:0070603;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG71437|UniProtKB=T1G0L7 T1G0L7 20214615 PTHR10885:SF0 ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE isomerase#PC00135;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG178665|UniProtKB=T1FDJ0 T1FDJ0 20206889 PTHR44006:SF1 U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 ribonucleoprotein complex#GO:1990904;catalytic step 2 spliceosome#GO:0071013;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 mRNA splicing#P00058>U5#P01474 HELRO|EnsemblGenome=HelroG164913|UniProtKB=T1EVY9 T1EVY9 20200739 PTHR12411:SF917 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN L cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197 macromolecule catabolic process#GO:0009057;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;proteolysis#GO:0006508;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;catabolic process#GO:0009056;organonitrogen compound catabolic process#GO:1901565;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;lysosome#GO:0005764;intracellular membrane-bounded organelle#GO:0043231;extracellular region#GO:0005576;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;organelle#GO:0043226;lytic vacuole#GO:0000323;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG186448|UniProtKB=T1FNZ7 T1FNZ7 20210544 PTHR45893:SF3 POLYCOMB GROUP RING FINGER PROTEIN POLYCOMB GROUP RING FINGER PROTEIN 3 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;PcG protein complex#GO:0031519;protein-containing complex#GO:0032991;PRC1 complex#GO:0035102;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG178905|UniProtKB=T1FDV8 T1FDV8 20207007 PTHR24243:SF230 G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG130545|UniProtKB=T1EHU2 T1EHU2 20196142 PTHR23071:SF1 PHOSPHATIDYLINOSITOL GLYCAN GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;phospholipid biosynthetic process#GO:0008654;macromolecule modification#GO:0043412;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycolipid metabolic process#GO:0006664;protein modification process#GO:0036211;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;glycerolipid biosynthetic process#GO:0045017;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;organic substance biosynthetic process#GO:1901576;liposaccharide metabolic process#GO:1903509;cellular process#GO:0009987;GPI anchor metabolic process#GO:0006505;membrane lipid biosynthetic process#GO:0046467;lipoprotein biosynthetic process#GO:0042158;primary metabolic process#GO:0044238;GPI anchor biosynthetic process#GO:0006506;carbohydrate derivative biosynthetic process#GO:1901137;membrane lipid metabolic process#GO:0006643;glycerophospholipid biosynthetic process#GO:0046474;glycolipid biosynthetic process#GO:0009247;organophosphate metabolic process#GO:0019637;lipoprotein metabolic process#GO:0042157;cellular lipid metabolic process#GO:0044255 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG167712|UniProtKB=T1EZP9 T1EZP9 20202049 PTHR31598:SF1 IQ DOMAIN-CONTAINING PROTEIN D DYNEIN REGULATORY COMPLEX PROTEIN 10 HELRO|EnsemblGenome=HelroG182845|UniProtKB=T1FIU7 T1FIU7 20208746 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG67893|UniProtKB=T1FZ72 T1FZ72 20214120 PTHR45920:SF4 FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;cortical cytoskeleton organization#GO:0030865;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;cortical actin cytoskeleton organization#GO:0030866 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG188412|UniProtKB=T1FPY8 T1FPY8 20210885 PTHR45859:SF1 TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA nucleoside-triphosphatase regulator activity#GO:0060589;nucleic acid binding#GO:0003676;translation regulator activity#GO:0045182;GTPase regulator activity#GO:0030695;binding#GO:0005488;organic cyclic compound binding#GO:0097159;molecular function regulator activity#GO:0098772;translation initiation factor activity#GO:0003743;translation regulator activity, nucleic acid binding#GO:0090079;enzyme regulator activity#GO:0030234;translation factor activity, RNA binding#GO:0008135;guanyl-nucleotide exchange factor activity#GO:0005085 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;translational initiation#GO:0006413;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG103005|UniProtKB=T1EDD6 T1EDD6 20194588 PTHR10841:SF17 SYNAPSIN SYNAPSIN neurotransmitter secretion#GO:0007269;cellular localization#GO:0051641;transport#GO:0006810;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;secretion#GO:0046903;neurotransmitter transport#GO:0006836;biological regulation#GO:0065007;signal release#GO:0023061;synaptic signaling#GO:0099536;establishment of localization in cell#GO:0051649;signaling#GO:0023052;cell-cell signaling#GO:0007267;export from cell#GO:0140352;secretion by cell#GO:0032940 synaptic vesicle membrane#GO:0030672;bounding membrane of organelle#GO:0098588;presynapse#GO:0098793;synapse#GO:0045202;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;cell junction#GO:0030054;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;transport vesicle membrane#GO:0030658;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;cytoplasmic vesicle membrane#GO:0030659;secretory vesicle#GO:0099503 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synapsin#P05775 HELRO|EnsemblGenome=HelroG68656|UniProtKB=T1FZH7 T1FZH7 20214225 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG106916|UniProtKB=T1EE59 T1EE59 20194861 PTHR22572:SF15 SUGAR-1-PHOSPHATE GUANYL TRANSFERASE MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE BETA transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 Mannose metabolism#P02752>Mannose 1-P guanylyl transferase#P03018 HELRO|EnsemblGenome=HelroG176453|UniProtKB=T1FAI7 T1FAI7 20205836 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG86723|UniProtKB=T1G6G0 T1G6G0 20216657 PTHR19376:SF37 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;RNA polymerase activity#GO:0097747;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;RNA polymerase II activity#GO:0001055 membrane-enclosed lumen#GO:0031974;RNA polymerase II, core complex#GO:0005665;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase II, holoenzyme#GO:0016591;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG194085|UniProtKB=T1FVN5 T1FVN5 20212881 PTHR23236:SF11 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC TRANSLATION INITIATION FACTOR 4H translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG189204|UniProtKB=T1FQS5 T1FQS5 20211172 PTHR24223:SF454 ATP-BINDING CASSETTE SUB-FAMILY C SUBFAMILY NOT NAMED transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG124246|UniProtKB=T1EH05 T1EH05 20195855 PTHR10155:SF32 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT LP02169P enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;phosphatidylinositol 3-kinase complex#GO:0005942;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;membrane#GO:0016020;transferase complex, transferring phosphorus-containing groups#GO:0061695;extrinsic component of membrane#GO:0019898 kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG175368|UniProtKB=T1F971 T1F971 20205370 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG77746|UniProtKB=T1G333 T1G333 20215481 PTHR48032:SF18 RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6 RRM DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185222|UniProtKB=T1FMI9 T1FMI9 20210038 PTHR12771:SF56 ENGULFMENT AND CELL MOTILITY CED-12 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG161478|UniProtKB=T1ERI6 T1ERI6 20199186 PTHR23122:SF14 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK PROTEIN PALS1 cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;cell-cell junction#GO:0005911;anchoring junction#GO:0070161;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG62268|UniProtKB=T1FWY1 T1FWY1 20213329 PTHR23359:SF70 NUCLEOTIDE KINASE ADENYLATE KINASE 1, ISOFORM B transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, phosphate group as acceptor#GO:0016776;catalytic activity#GO:0003824;kinase activity#GO:0016301 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 nucleotide kinase#PC00172;kinase#PC00137 De novo purine biosynthesis#P02738>Adenylate kinase#P02896 HELRO|EnsemblGenome=HelroG62284|UniProtKB=T1FWY6 T1FWY6 20213334 PTHR11254:SF429 HECT DOMAIN UBIQUITIN-PROTEIN LIGASE E3 UBIQUITIN-PROTEIN LIGASE SU(DX) transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG191688|UniProtKB=T1FT76 T1FT76 20212023 PTHR19134:SF562 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE PROTEIN-TYROSINE-PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG169918|UniProtKB=T1F2G1 T1F2G1 20203011 PTHR10201:SF323 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE-21 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG83597|UniProtKB=T1G579 T1G579 20216227 PTHR45682:SF1 AGAP008228-PA DUAL SPECIFICITY PROTEIN PHOSPHATASE 3 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 regulation of cell communication#GO:0010646;regulation of MAPK cascade#GO:0043408;negative regulation of biological process#GO:0048519;negative regulation of response to stimulus#GO:0048585;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;negative regulation of MAPK cascade#GO:0043409;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of cellular process#GO:0048523;negative regulation of cell communication#GO:0010648 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG182591|UniProtKB=T1FIF4 T1FIF4 20208603 PTHR13491:SF0 ZCCHC10 PROTEIN ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10 HELRO|EnsemblGenome=HelroG181660|UniProtKB=T1FH77 T1FH77 20208176 PTHR32463:SF0 L-FUCOSE KINASE L-FUCOSE KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;biosynthetic process#GO:0009058;nucleotide-sugar metabolic process#GO:0009225;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;heterocycle metabolic process#GO:0046483;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 kinase#PC00137 HELRO|EnsemblGenome=HelroG175626|UniProtKB=T1F9F9 T1F9F9 20205458 PTHR45638:SF11 CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A protein-containing complex binding#GO:0044877;binding#GO:0005488 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG141893|UniProtKB=T1EJ45 T1EJ45 20196595 PTHR12570:SF92 FAMILY NOT NAMED SPICHTHYIN, ISOFORM B localization#GO:0051179;monoatomic cation transport#GO:0006812;metal ion transport#GO:0030001;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG193036|UniProtKB=T1FUJ8 T1FUJ8 20212494 PTHR45734:SF10 TENSIN BLISTERY, ISOFORM A cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG179892|UniProtKB=T1FF83 T1FF83 20207482 PTHR15933:SF20 PROTEIN CBG16327 F-BOX DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193403|UniProtKB=T1FUY7 T1FUY7 20212633 PTHR45861:SF1 DNA POLYMERASE ALPHA CATALYTIC SUBUNIT DNA POLYMERASE ALPHA CATALYTIC SUBUNIT DNA replication origin binding#GO:0003688;nucleic acid binding#GO:0003676;DNA-directed DNA polymerase activity#GO:0003887;single-stranded DNA binding#GO:0003697;binding#GO:0005488;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transferase activity#GO:0016740;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;catalytic activity, acting on DNA#GO:0140097;protein-containing complex binding#GO:0044877;DNA polymerase activity#GO:0034061 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;nuclear DNA replication#GO:0033260;macromolecule metabolic process#GO:0043170;cell cycle process#GO:0022402;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;mitotic cell cycle process#GO:1903047;primary metabolic process#GO:0044238;mitotic cell cycle#GO:0000278;nucleic acid metabolic process#GO:0090304;mitotic DNA replication initiation#GO:1902975;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mitotic DNA replication#GO:1902969;DNA-templated DNA replication#GO:0006261;cell cycle#GO:0007049;DNA replication#GO:0006260;DNA replication initiation#GO:0006270;cell cycle DNA replication#GO:0044786;metabolic process#GO:0008152;DNA strand elongation involved in DNA replication#GO:0006271;DNA metabolic process#GO:0006259;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;DNA-directed RNA polymerase complex#GO:0000428;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;transferase complex#GO:1990234;replisome#GO:0030894;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;DNA polymerase complex#GO:0042575;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;nuclear replication fork#GO:0043596;chromosome#GO:0005694;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513;replication fork#GO:0005657 DNA metabolism protein#PC00009 DNA replication#P00017>Pol alpha#P00531 HELRO|EnsemblGenome=HelroG108549|UniProtKB=T1EEK3 T1EEK3 20195005 PTHR19918:SF1 CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED FIZZY-RELATED PROTEIN HOMOLOG protein-containing complex binding#GO:0044877;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;binding#GO:0005488 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of protein metabolic process#GO:0051246;regulation of catabolic process#GO:0009894;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of proteasomal protein catabolic process#GO:1901800;protein catabolic process#GO:0030163;organonitrogen compound catabolic process#GO:1901565;regulation of protein catabolic process#GO:0042176;regulation of proteolysis involved in protein catabolic process#GO:1903050;positive regulation of proteolysis#GO:0045862;modification-dependent macromolecule catabolic process#GO:0043632;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;positive regulation of biological process#GO:0048518;proteolysis involved in protein catabolic process#GO:0051603;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;regulation of proteolysis#GO:0030162;macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;positive regulation of proteolysis involved in protein catabolic process#GO:1903052;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;organonitrogen compound metabolic process#GO:1901564;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of proteasomal protein catabolic process#GO:0061136;regulation of primary metabolic process#GO:0080090;positive regulation of protein metabolic process#GO:0051247;anaphase-promoting complex-dependent catabolic process#GO:0031145;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;positive regulation of catabolic process#GO:0009896;positive regulation of protein catabolic process#GO:0045732;regulation of metabolic process#GO:0019222;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434 ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234;anaphase-promoting complex#GO:0005680;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG173602|UniProtKB=T1F708 T1F708 20204607 PTHR20961:SF38 GLYCOSYLTRANSFERASE PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2 transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG162251|UniProtKB=T1ESF0 T1ESF0 20199500 PTHR11537:SF105 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAL monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG162801|UniProtKB=T1ET64 T1ET64 20199764 PTHR33395:SF21 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED PERICARDIN heart morphogenesis#GO:0003007;system development#GO:0048731;heart development#GO:0007507;circulatory system development#GO:0072359;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;animal organ development#GO:0048513;multicellular organism development#GO:0007275;developmental process#GO:0032502;animal organ morphogenesis#GO:0009887;multicellular organismal process#GO:0032501;cell adhesion#GO:0007155;cellular process#GO:0009987;post-embryonic development#GO:0009791 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG111699|UniProtKB=T1EFD8 T1EFD8 20195290 PTHR45754:SF3 METHYLENETETRAHYDROFOLATE REDUCTASE METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH) nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;flavin adenine dinucleotide binding#GO:0050660;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;oxidoreductase activity#GO:0016491 cellular aromatic compound metabolic process#GO:0006725;sulfur compound metabolic process#GO:0006790;proteinogenic amino acid biosynthetic process#GO:0170038;folic acid-containing compound metabolic process#GO:0006760;biosynthetic process#GO:0009058;carboxylic acid biosynthetic process#GO:0046394;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular modified amino acid metabolic process#GO:0006575;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;L-amino acid metabolic process#GO:0170033;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;heterocycle metabolic process#GO:0046483;proteinogenic amino acid metabolic process#GO:0170039;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;aspartate family amino acid biosynthetic process#GO:0009067;alpha-amino acid biosynthetic process#GO:1901607;aspartate family amino acid metabolic process#GO:0009066;L-amino acid biosynthetic process#GO:0170034;small molecule biosynthetic process#GO:0044283;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG110821|UniProtKB=T1EF54 T1EF54 20195206 PTHR47368:SF2 NUMB PID DOMAIN-CONTAINING PROTEIN cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG154558|UniProtKB=T1ELF2 T1ELF2 20197402 PTHR10745:SF0 GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2 GLYCINE--TRNA LIGASE catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG109597|UniProtKB=T1EEV2 T1EEV2 20195104 PTHR10569:SF2 GLYCOGEN DEBRANCHING ENZYME GLYCOGEN DEBRANCHING ENZYME glucosidase activity#GO:0015926;alpha-glucosidase activity#GO:0090599;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;hexosyltransferase activity#GO:0016758 glucan metabolic process#GO:0044042;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;glycogen metabolic process#GO:0005977;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;cellular process#GO:0009987;energy derivation by oxidation of organic compounds#GO:0015980;primary metabolic process#GO:0044238;polysaccharide metabolic process#GO:0005976;carbohydrate catabolic process#GO:0016052;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;energy reserve metabolic process#GO:0006112;carbohydrate metabolic process#GO:0005975;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG92435|UniProtKB=T1G8G2 T1G8G2 20217359 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG62058|UniProtKB=T1FWV0 T1FWV0 20213298 PTHR10590:SF4 SODIUM/NUCLEOSIDE COTRANSPORTER SOLUTE CARRIER FAMILY 28 MEMBER 3 carbohydrate derivative transmembrane transporter activity#GO:1901505;secondary active transmembrane transporter activity#GO:0015291;nucleoside transmembrane transporter activity#GO:0005337;transmembrane transporter activity#GO:0022857;symporter activity#GO:0015293;nucleobase-containing compound transmembrane transporter activity#GO:0015932;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215 localization#GO:0051179;organic substance transport#GO:0071702;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;nucleobase-containing compound transport#GO:0015931;transport#GO:0006810;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG176231|UniProtKB=T1FAB5 T1FAB5 20205764 PTHR11202:SF3 SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER SPROUTY-RELATED PROTEIN WITH EVH-1 DOMAIN, ISOFORM C enzyme binding#GO:0019899;protein binding#GO:0005515;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900 regulation of cell communication#GO:0010646;regulation of MAPK cascade#GO:0043408;negative regulation of biological process#GO:0048519;negative regulation of response to stimulus#GO:0048585;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;negative regulation of MAPK cascade#GO:0043409;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of cellular process#GO:0048523;negative regulation of cell communication#GO:0010648 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG181750|UniProtKB=T1FHA2 T1FHA2 20208201 PTHR15272:SF0 CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;nucleosome organization#GO:0034728;nucleosome assembly#GO:0006334;protein-containing complex organization#GO:0043933;protein-containing complex assembly#GO:0065003;chromatin organization#GO:0006325;cellular component organization#GO:0016043;cellular process#GO:0009987;chromatin remodeling#GO:0006338;protein-DNA complex assembly#GO:0065004 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG113569|UniProtKB=T1EFT8 T1EFT8 20195440 PTHR11685:SF371 RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE RNF14 ubiquitin-like protein conjugating enzyme binding#GO:0044390;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;enzyme binding#GO:0019899;protein binding#GO:0005515;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG187486|UniProtKB=T1FPA1 T1FPA1 20210648 PTHR24353:SF153 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;cytosol#GO:0005829;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Enkephalin release#P05913>PKA#P05972;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Endothelin signaling pathway#P00019>PKA#P00570;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059 HELRO|EnsemblGenome=HelroG177781|UniProtKB=T1FC91 T1FC91 20206440 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG175531|UniProtKB=T1F9D0 T1F9D0 20205429 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED FMRFAMIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG166961|UniProtKB=T1EYT3 T1EYT3 20201733 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG173370|UniProtKB=T1F6Q6 T1F6Q6 20204505 PTHR11362:SF82 PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4 protease inhibitor#PC00191 EGF receptor signaling pathway#P00018>RKIP#P00548;FGF signaling pathway#P00021>RKIP#P00630 HELRO|EnsemblGenome=HelroG188550|UniProtKB=T1FQ41 T1FQ41 20210938 PTHR23236:SF119 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H NUCLEAR RNA-BINDING PROTEIN SART-3 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG89553|UniProtKB=T1G7E1 T1G7E1 20216988 PTHR24006:SF758 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36 cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG84839|UniProtKB=T1G5P5 T1G5P5 20216392 PTHR28605:SF1 CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE) CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HELRO|EnsemblGenome=HelroG181959|UniProtKB=T1FHI7 T1FHI7 20208286 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189052|UniProtKB=T1FQL4 T1FQL4 20211111 PTHR24416:SF566 TYROSINE-PROTEIN KINASE RECEPTOR EPIDERMAL GROWTH FACTOR RECEPTOR signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 negative regulation of biological process#GO:0048519;signal transduction#GO:0007165;neurogenesis#GO:0022008;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;positive regulation of cell population proliferation#GO:0008284;regulation of catalytic activity#GO:0050790;nervous system development#GO:0007399;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;system development#GO:0048731;cell differentiation#GO:0030154;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;negative regulation of programmed cell death#GO:0043069;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;regulation of programmed cell death#GO:0043067;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;cellular developmental process#GO:0048869;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;regulation of apoptotic process#GO:0042981;regulation of cell population proliferation#GO:0042127;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;negative regulation of apoptotic process#GO:0043066;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;anatomical structure development#GO:0048856;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 basal plasma membrane#GO:0009925;receptor complex#GO:0043235;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;basal part of cell#GO:0045178;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 EGF receptor signaling pathway#P00018>EGFR#P00542;Cadherin signaling pathway#P00012>EGFR#P00466 HELRO|EnsemblGenome=HelroG69340|UniProtKB=T1FZT4 T1FZT4 20214332 PTHR24346:SF45 MAP/MICROTUBULE AFFINITY-REGULATING KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG168289|UniProtKB=T1F0E5 T1F0E5 20202295 PTHR24410:SF23 HL07962P-RELATED BTB DOMAIN-CONTAINING PROTEIN-RELATED defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG140768|UniProtKB=T1EJ18 T1EJ18 20196568 PTHR24256:SF470 TRYPTASE-RELATED INACTIVE CLIP DOMAIN-CONTAINING SERINE PROTEASE A30 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG142066|UniProtKB=T1EJ48 T1EJ48 20196598 PTHR24246:SF27 OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR ADENOSINE RECEPTOR, ISOFORM A G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HELRO|EnsemblGenome=HelroG87535|UniProtKB=T1G6R8 T1G6R8 20216765 PTHR23506:SF23 GH10249P GH10249P secondary carrier transporter#PC00258;transporter#PC00227 Adrenaline and noradrenaline biosynthesis#P00001>VAT1#P00071;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>VAChT#P01078;5HT3 type receptor mediated signaling pathway#P04375>5HT vesicular transporter#P04424;5HT2 type receptor mediated signaling pathway#P04374>5HT vesicular transporter#P04418;Nicotinic acetylcholine receptor signaling pathway#P00044>VAChT#P01089;5HT4 type receptor mediated signaling pathway#P04376>5HT vesicular transporter#P04432;5HT1 type receptor mediated signaling pathway#P04373>5HT vesicular transporter#P04410 HELRO|EnsemblGenome=HelroG167678|UniProtKB=T1EZN7 T1EZN7 20202037 PTHR22605:SF16 RZ-TYPE DOMAIN-CONTAINING PROTEIN E3 UBIQUITIN-PROTEIN LIGASE RNF213 HELRO|EnsemblGenome=HelroG157612|UniProtKB=T1EMD8 T1EMD8 20197738 PTHR11461:SF211 SERINE PROTEASE INHIBITOR, SERPIN GH10112P-RELATED protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG94829|UniProtKB=T1G933 T1G933 20217580 PTHR11588:SF462 TUBULIN TUBULIN ALPHA CHAIN carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;structural molecule activity#GO:0005198;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;structural constituent of cytoskeleton#GO:0005200 cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;microtubule-based process#GO:0007017;organelle organization#GO:0006996;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;cell cycle#GO:0007049;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 tubulin#PC00228;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG181576|UniProtKB=T1FH46 T1FH46 20208145 PTHR38537:SF8 JITTERBUG, ISOFORM N FILAMIN-A HELRO|EnsemblGenome=HelroG153737|UniProtKB=T1ELB3 T1ELB3 20197363 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188369|UniProtKB=T1FPX5 T1FPX5 20210872 PTHR11534:SF9 MYOGENIC FACTOR MYOGENIC-DETERMINATION PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of cell differentiation#GO:0045597;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of cell differentiation#GO:0045595;positive regulation of developmental process#GO:0051094;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG73261|UniProtKB=T1G1C3 T1G1C3 20214871 PTHR23359:SF234 NUCLEOTIDE KINASE ADENYLATE KINASE 2, MITOCHONDRIAL transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, phosphate group as acceptor#GO:0016776;catalytic activity#GO:0003824;kinase activity#GO:0016301 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 nucleotide kinase#PC00172;kinase#PC00137 De novo purine biosynthesis#P02738>Adenylate kinase#P02896 HELRO|EnsemblGenome=HelroG113705|UniProtKB=T1EFV4 T1EFV4 20195456 PTHR23284:SF0 PROLACTIN REGULATORY ELEMENT BINDING PROTEIN PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;regulation of organelle organization#GO:0033043;transport#GO:0006810;vesicle-mediated transport#GO:0016192;regulation of cellular component organization#GO:0051128;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;regulation of biological process#GO:0050789;localization#GO:0051179;regulation of protein-containing complex assembly#GO:0043254;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG185520|UniProtKB=T1FMX4 T1FMX4 20210173 PTHR10836:SF76 GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED dehydrogenase#PC00092;oxidoreductase#PC00176 Glycolysis#P00024>Glyceraldehyde 3-phosphate dehydrogenase#P00676;Huntington disease#P00029>GAPDH#P00810 HELRO|EnsemblGenome=HelroG186281|UniProtKB=T1FNW8 T1FNW8 20210515 PTHR24189:SF69 MYOTROPHIN MYOTROPHIN regulation of anatomical structure size#GO:0090066;regulation of actin filament length#GO:0030832;regulation of organelle organization#GO:0033043;regulation of actin filament organization#GO:0110053;regulation of cellular component organization#GO:0051128;regulation of protein-containing complex disassembly#GO:0043244;cellular component organization#GO:0016043;regulation of actin polymerization or depolymerization#GO:0008064;cellular process#GO:0009987;regulation of actin filament polymerization#GO:0030833;regulation of cellular component size#GO:0032535;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cytoskeleton organization#GO:0051493;regulation of protein-containing complex assembly#GO:0043254;regulation of biological quality#GO:0065008;regulation of protein depolymerization#GO:1901879;regulation of actin filament depolymerization#GO:0030834;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament-based process#GO:0032970;regulation of protein polymerization#GO:0032271 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG180415|UniProtKB=T1FFW7 T1FFW7 20207716 PTHR24249:SF411 HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG174320|UniProtKB=T1F7Z9 T1F7Z9 20204948 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG191617|UniProtKB=T1FT47 T1FT47 20211994 PTHR44170:SF56 PROTEIN SIDEKICK FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG176369|UniProtKB=T1FAG3 T1FAG3 20205812 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG80870|UniProtKB=T1G466 T1G466 20215864 PTHR10217:SF548 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL GH12235P monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG131923|UniProtKB=T1EHW6 T1EHW6 20196166 PTHR46223:SF4 HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED N-methyltransferase activity#GO:0008170;histone modifying activity#GO:0140993;transferase activity#GO:0016740;histone methyltransferase activity#GO:0042054;catalytic activity#GO:0003824;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;protein-lysine N-methyltransferase activity#GO:0016279;catalytic activity, acting on a protein#GO:0140096;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;lysine N-methyltransferase activity#GO:0016278;protein methyltransferase activity#GO:0008276 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG156810|UniProtKB=T1EM15 T1EM15 20197615 PTHR11817:SF3 PYRUVATE KINASE AT14039P-RELATED transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;ribonucleoside triphosphate metabolic process#GO:0009199;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative metabolic process#GO:1901135;heterocycle catabolic process#GO:0046700;organonitrogen compound catabolic process#GO:1901565;ribonucleotide catabolic process#GO:0009261;pyridine nucleotide metabolic process#GO:0019362;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;cellular nitrogen compound catabolic process#GO:0044270;purine-containing compound catabolic process#GO:0072523;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;purine nucleotide catabolic process#GO:0006195;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;purine ribonucleotide catabolic process#GO:0009154;nucleoside phosphate metabolic process#GO:0006753;carbohydrate catabolic process#GO:0016052;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;catabolic process#GO:0009056;nucleoside diphosphate metabolic process#GO:0009132;organic substance catabolic process#GO:1901575;carbohydrate metabolic process#GO:0005975;purine nucleotide metabolic process#GO:0006163;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;oxoacid metabolic process#GO:0043436;nucleoside phosphate catabolic process#GO:1901292;carbohydrate derivative catabolic process#GO:1901136;purine ribonucleoside triphosphate metabolic process#GO:0009205;generation of precursor metabolites and energy#GO:0006091;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;nucleotide catabolic process#GO:0009166;cellular nitrogen compound metabolic process#GO:0034641;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;nucleoside diphosphate catabolic process#GO:0009134;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;organophosphate catabolic process#GO:0046434;aromatic compound catabolic process#GO:0019439;glycolytic process#GO:0006096;organic cyclic compound catabolic process#GO:1901361;organophosphate metabolic process#GO:0019637;purine nucleoside triphosphate metabolic process#GO:0009144;nucleobase-containing compound catabolic process#GO:0034655;nucleotide metabolic process#GO:0009117;carboxylic acid metabolic process#GO:0019752;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 kinase#PC00137 Pyruvate metabolism#P02772>Pyruvate Kinase#P03132 HELRO|EnsemblGenome=HelroG71733|UniProtKB=T1G0Q9 T1G0Q9 20214657 PTHR19303:SF71 TRANSPOSON ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG122380|UniProtKB=T1EGU6 T1EGU6 20195796 PTHR45689:SF5 I[[H]] CHANNEL, ISOFORM E I[[H]] CHANNEL, ISOFORM E monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;sodium ion transport#GO:0006814;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;regulation of membrane depolarization#GO:0003254;sodium ion transmembrane transport#GO:0035725;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG106777|UniProtKB=T1EE48 T1EE48 20194850 PTHR16301:SF25 IMPACT-RELATED PROTEIN IMPACT cellular response to stimulus#GO:0051716;regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;cellular process#GO:0009987;regulation of translational initiation#GO:0006446;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular biosynthetic process#GO:0031326;response to stress#GO:0006950;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;cellular response to stress#GO:0033554;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG180945|UniProtKB=T1FGG3 T1FGG3 20207912 PTHR13044:SF14 ACTIVATING TRANSCRIPTION FACTOR ATF 4/5 CRYPTOCEPHAL, ISOFORM A DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG66521|UniProtKB=T1FYM2 T1FYM2 20213920 PTHR11771:SF180 LIPOXYGENASE LIPOXYGENASE DOMAIN-CONTAINING PROTEIN oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;dioxygenase activity#GO:0051213 lipid metabolic process#GO:0006629;lipid oxidation#GO:0034440;cellular metabolic process#GO:0044237;lipid modification#GO:0030258;cellular lipid metabolic process#GO:0044255;cellular process#GO:0009987;metabolic process#GO:0008152;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG185681|UniProtKB=T1FN50 T1FN50 20210248 PTHR11851:SF149 METALLOPROTEASE GH01077P cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG105234|UniProtKB=T1EDR9 T1EDR9 20194721 PTHR14119:SF3 HYDROLASE ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG185455|UniProtKB=T1FMU5 T1FMU5 20210144 PTHR45810:SF10 HISTONE H3.2 HISTONE H3 chromatin/chromatin-binding, or -regulatory protein#PC00077 DNA replication#P00017>Histones#P00527 HELRO|EnsemblGenome=HelroG80748|UniProtKB=T1G449 T1G449 20215847 PTHR44133:SF2 CLEAVAGE STIMULATION FACTOR SUBUNIT 1 CLEAVAGE STIMULATION FACTOR SUBUNIT 1 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;mRNA cleavage factor complex#GO:0005849;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG96284|UniProtKB=T1G9B1 T1G9B1 20217658 PTHR24393:SF15 ZINC FINGER PROTEIN IP01243P-RELATED DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG190681|UniProtKB=T1FS71 T1FS71 20211668 PTHR24083:SF4 NUCLEAR HORMONE RECEPTOR PHOTORECEPTOR-SPECIFIC NUCLEAR RECEPTOR cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;signaling receptor activity#GO:0038023;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG69267|UniProtKB=T1FZS3 T1FZS3 20214321 PTHR24070:SF258 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY RAS-RELATED PROTEIN RAL-A GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 small GTPase#PC00208;G-protein#PC00020 Ras Pathway#P04393>Ral#P04550 HELRO|EnsemblGenome=HelroG98504|UniProtKB=T1G9N3 T1G9N3 20217779 PTHR45024:SF2 DEHYDROGENASES, SHORT CHAIN SCP2 DOMAIN-CONTAINING PROTEIN dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG189608|UniProtKB=T1FR71 T1FR71 20211318 PTHR19964:SF92 MULTIPLE PDZ DOMAIN PROTEIN PATJ HOMOLOG scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG173369|UniProtKB=T1F6Q5 T1F6Q5 20204504 PTHR14038:SF0 BAT2 HLA-B-ASSOCIATED TRANSCRIPT 2 LP18708P cellular developmental process#GO:0048869;cell differentiation#GO:0030154;cellular process#GO:0009987;developmental process#GO:0032502 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG169769|UniProtKB=T1F2B3 T1F2B3 20202963 PTHR10161:SF14 TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5 TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5 hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG173259|UniProtKB=T1F6M1 T1F6M1 20204470 PTHR11462:SF59 JUN TRANSCRIPTION FACTOR-RELATED BZIP DOMAIN-CONTAINING PROTEIN cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription factor binding#GO:0008134;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;protein binding#GO:0005515;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of cell population proliferation#GO:0042127;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667 DNA-binding transcription factor#PC00218;basic leucine zipper transcription factor#PC00056 HELRO|EnsemblGenome=HelroG176105|UniProtKB=T1FA48 T1FA48 20205697 PTHR36191:SF1 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG110978|UniProtKB=T1EF68 T1EF68 20195220 PTHR12928:SF0 FRG1 PROTEIN FSHD REGION GENE 1 cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 membrane-enclosed lumen#GO:0031974;supramolecular complex#GO:0099080;catalytic step 2 spliceosome#GO:0071013;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;organelle#GO:0043226;contractile fiber#GO:0043292;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG194215|UniProtKB=T1FVT5 T1FVT5 20212931 PTHR13448:SF0 TRANSMEMBRANE PROTEIN 214 TRANSMEMBRANE PROTEIN 214 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG93147|UniProtKB=T1G8U1 T1G8U1 20217488 PTHR12454:SF11 TRIMERIC INTRACELLULAR CATION CHANNEL GH25683P ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG137131|UniProtKB=T1EIH8 T1EIH8 20196378 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG65239|UniProtKB=T1FY49 T1FY49 20213747 PTHR24346:SF74 MAP/MICROTUBULE AFFINITY-REGULATING KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;microtubule cytoskeleton organization#GO:0000226;cell communication#GO:0007154;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;regulation of cellular process#GO:0050794;organelle organization#GO:0006996;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;intracellular signal transduction#GO:0035556;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG168360|UniProtKB=T1F0G9 T1F0G9 20202319 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG107075|UniProtKB=T1EE72 T1EE72 20194874 PTHR19924:SF26 UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG cellular aromatic compound metabolic process#GO:0006725;positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of transcription by RNA polymerase I#GO:0045943;cellular component biogenesis#GO:0044085;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;positive regulation of cellular metabolic process#GO:0031325;RNA processing#GO:0006396;gene expression#GO:0010467;regulation of RNA biosynthetic process#GO:2001141;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;positive regulation of metabolic process#GO:0009893;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;ribosome biogenesis#GO:0042254;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;regulation of transcription by RNA polymerase I#GO:0006356;macromolecule biosynthetic process#GO:0009059;regulation of DNA-templated transcription#GO:0006355;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;positive regulation of cellular biosynthetic process#GO:0031328;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;rRNA metabolic process#GO:0016072;regulation of cellular process#GO:0050794;ribonucleoprotein complex biogenesis#GO:0022613;biological regulation#GO:0065007;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG178355|UniProtKB=T1FD34 T1FD34 20206733 PTHR12011:SF347 ADHESION G-PROTEIN COUPLED RECEPTOR FI21270P1-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG74084|UniProtKB=T1G1M2 T1G1M2 20214970 PTHR11630:SF48 DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER DNA HELICASE MCM9 ATP-dependent activity, acting on DNA#GO:0008094;nucleic acid binding#GO:0003676;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;single-stranded DNA binding#GO:0003697;DNA binding#GO:0003677;catalytic activity, acting on a nucleic acid#GO:0140640;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097;single-stranded DNA helicase activity#GO:0017116 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;double-strand break repair via homologous recombination#GO:0000724;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;response to stress#GO:0006950;nitrogen compound metabolic process#GO:0006807;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;MCM complex#GO:0042555;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG85561|UniProtKB=T1G5Z2 T1G5Z2 20216489 PTHR10845:SF192 REGULATOR OF G PROTEIN SIGNALING DOUBLE HIT, ISOFORM B G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731 HELRO|EnsemblGenome=HelroG177296|UniProtKB=T1FBG9 T1FBG9 20206168 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG108795|UniProtKB=T1EEM5 T1EEM5 20195027 PTHR24342:SF12 SERINE/THREONINE-PROTEIN KINASE 17 DEATH-ASSOCIATED PROTEIN KINASE RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 positive regulation of apoptotic process#GO:0043065;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of apoptotic process#GO:0042981;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;intracellular signal transduction#GO:0035556;signaling#GO:0023052;positive regulation of biological process#GO:0048518;regulation of programmed cell death#GO:0043067 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG63549|UniProtKB=T1FXH3 T1FXH3 20213521 PTHR10343:SF84 5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1 kinase modulator#PC00140 Gonadotropin-releasing hormone receptor pathway#P06664>AMPK#P06830;p53 pathway by glucose deprivation#P04397>AMPK#P04639 HELRO|EnsemblGenome=HelroG85912|UniProtKB=T1G642 T1G642 20216539 PTHR11533:SF299 PROTEASE M1 ZINC METALLOPROTEASE AMINOPEPTIDASE metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;amide binding#GO:0033218;metal ion binding#GO:0046872;peptidase activity#GO:0008233;metalloaminopeptidase activity#GO:0070006;cation binding#GO:0043169;peptide binding#GO:0042277;hydrolase activity#GO:0016787;aminopeptidase activity#GO:0004177;exopeptidase activity#GO:0008238;ion binding#GO:0043167;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;peptide catabolic process#GO:0043171;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;membrane#GO:0016020;extracellular region#GO:0005576;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG156168|UniProtKB=T1ELS1 T1ELS1 20197521 PTHR13829:SF2 SNRNP CORE PROTEIN FAMILY MEMBER U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;mRNA splicing, via spliceosome#GO:0000398;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 supramolecular complex#GO:0099080;catalytic step 2 spliceosome#GO:0071013;U6 snRNP#GO:0005688;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;P-body#GO:0000932;catalytic complex#GO:1902494;U4/U6 x U5 tri-snRNP complex#GO:0046540;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic ribonucleoprotein granule#GO:0036464;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;spliceosomal tri-snRNP complex#GO:0097526;precatalytic spliceosome#GO:0071011;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG77701|UniProtKB=T1G325 T1G325 20215473 PTHR15486:SF96 ANCIENT UBIQUITOUS PROTEIN LIPID DROPLET-REGULATING VLDL ASSEMBLY FACTOR AUP1 cellular anatomical entity#GO:0110165;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194364|UniProtKB=T1FVZ7 T1FVZ7 20212993 PTHR44157:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 11 DNAJ HOMOLOG SUBFAMILY C MEMBER 11 cellular component organization or biogenesis#GO:0071840;membrane organization#GO:0061024;organelle organization#GO:0006996;cellular component organization#GO:0016043;mitochondrial membrane organization#GO:0007006;mitochondrion organization#GO:0007005;cellular process#GO:0009987;inner mitochondrial membrane organization#GO:0007007 chaperone#PC00072 HELRO|EnsemblGenome=HelroG150702|UniProtKB=T1EKH0 T1EKH0 20197070 PTHR23503:SF8 SOLUTE CARRIER FAMILY 2 FACILITATED GLUCOSE TRANSPORTER PROTEIN 1 transmembrane transporter activity#GO:0022857;sugar transmembrane transporter activity#GO:0051119;transporter activity#GO:0005215;carbohydrate transmembrane transporter activity#GO:0015144 localization#GO:0051179;organic substance transport#GO:0071702;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;cellular process#GO:0009987;carbohydrate transmembrane transport#GO:0034219;carbohydrate transport#GO:0008643 cellular anatomical entity#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG188901|UniProtKB=T1FQG5 T1FQG5 20211062 PTHR15126:SF4 SH3-BINDING SH3 DOMAIN-BINDING PROTEIN 2 HELRO|EnsemblGenome=HelroG93524|UniProtKB=T1G8W2 T1G8W2 20217509 PTHR11552:SF147 GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE CHOLINE DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG185799|UniProtKB=T1FNA8 T1FNA8 20210305 PTHR47992:SF63 PROTEIN PHOSPHATASE ALPHABET, ISOFORM E protein phosphatase#PC00195;protein modifying enzyme#PC00260 DPP-SCW signaling pathway#P06212>PPM1A#P06261;Activin beta signaling pathway#P06210>PPM1A#P06237;MYO signaling pathway#P06215>PPM1A#P06317;BMP/activin signaling pathway-drosophila#P06211>PPM1A#P06247;ALP23B signaling pathway#P06209>PPM1A#P06226;GBB signaling pathway#P06214>PPM1A#P06296;DPP signaling pathway#P06213>PPM1A#P06289;SCW signaling pathway#P06216>PPM1A#P06332 HELRO|EnsemblGenome=HelroG186189|UniProtKB=T1FNS5 T1FNS5 20210472 PTHR23291:SF112 BAX INHIBITOR-RELATED GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;membrane#GO:0016020;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG156994|UniProtKB=T1EM46 T1EM46 20197646 PTHR10367:SF17 MRNA-CAPPING ENZYME MRNA-CAPPING ENZYME catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mRNA processing#GO:0006397;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 RNA processing factor#PC00147;RNA metabolism protein#PC00031;mRNA capping factor#PC00145 HELRO|EnsemblGenome=HelroG171773|UniProtKB=T1F4N1 T1F4N1 20203780 PTHR47160:SF5 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161001|UniProtKB=T1EQZ6 T1EQZ6 20198996 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166962|UniProtKB=T1EYT4 T1EYT4 20201734 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG151661|UniProtKB=T1EKL5 T1EKL5 20197115 PTHR19308:SF39 PHOSPHATIDYLCHOLINE TRANSFER PROTEIN PHOSPHATIDYLCHOLINE TRANSFER PROTEIN HELRO|EnsemblGenome=HelroG64571|UniProtKB=T1FXW6 T1FXW6 20213664 PTHR11043:SF0 ZETA-COAT PROTEIN COATOMER SUBUNIT ZETA cellular localization#GO:0051641;intra-Golgi vesicle-mediated transport#GO:0006891;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;vesicle coat#GO:0030120;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;Golgi-associated vesicle membrane#GO:0030660;protein-containing complex#GO:0032991;COPI vesicle coat#GO:0030126;endomembrane system#GO:0012505;membrane coat#GO:0030117;coated vesicle membrane#GO:0030662;COPI-coated vesicle#GO:0030137;Golgi-associated vesicle#GO:0005798;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;coated membrane#GO:0048475;cytoplasmic vesicle membrane#GO:0030659 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG178140|UniProtKB=T1FCT8 T1FCT8 20206637 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG166252|UniProtKB=T1EXY0 T1EXY0 20201430 PTHR44755:SF11 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED ATRIAL NATRIURETIC PEPTIDE RECEPTOR 3 ISOFORM X1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide hormone binding#GO:0017046;hormone binding#GO:0042562;binding#GO:0005488;peptide binding#GO:0042277;amide binding#GO:0033218 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG178341|UniProtKB=T1FD33 T1FD33 20206732 PTHR12868:SF0 NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transporter complex#GO:1990351;oxidoreductase complex#GO:1990204;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;respirasome#GO:0070469;mitochondrial respiratory chain complex I#GO:0005747;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;transmembrane transporter complex#GO:1902495;mitochondrial respirasome#GO:0005746;membrane-bounded organelle#GO:0043227;respiratory chain complex I#GO:0045271;NADH dehydrogenase complex#GO:0030964;mitochondrial protein-containing complex#GO:0098798 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG130334|UniProtKB=T1EHT6 T1EHT6 20196136 PTHR24211:SF20 LIM DOMAIN-CONTAINING PROTEIN PROTEIN ESPINAS-RELATED scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG188652|UniProtKB=T1FQ81 T1FQ81 20210978 PTHR18916:SF88 DYNACTIN 1-RELATED MICROTUBULE-BINDING CAP-GLY DOMAIN-CONTAINING PROTEIN cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;microtubule plus-end binding#GO:0051010;binding#GO:0005488 cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987;cytoplasmic microtubule organization#GO:0031122 supramolecular complex#GO:0099080;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;supramolecular polymer#GO:0099081;cellular anatomical entity#GO:0110165;cell cortex#GO:0005938;cell periphery#GO:0071944;supramolecular fiber#GO:0099512;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;microtubule plus-end#GO:0035371;microtubule#GO:0005874 chaperone#PC00072 HELRO|EnsemblGenome=HelroG74962|UniProtKB=T1G1Y6 T1G1Y6 20215084 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG121963|UniProtKB=T1EGT4 T1EGT4 20195784 PTHR10151:SF120 ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE BIS(5'-ADENOSYL)-TRIPHOSPHATASE metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG82982|UniProtKB=T1G4Y9 T1G4Y9 20216137 PTHR24115:SF421 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF25 pyrophosphatase activity#GO:0016462;cytoskeletal protein binding#GO:0008092;microtubule motor activity#GO:0003777;tubulin binding#GO:0015631;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;cytoskeletal motor activity#GO:0003774;microtubule binding#GO:0008017;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;microtubule associated complex#GO:0005875;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG163785|UniProtKB=T1EUH1 T1EUH1 20200221 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192951|UniProtKB=T1FUG3 T1FUG3 20212459 PTHR21528:SF0 DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1 DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1 prenyltransferase activity#GO:0004659;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;macromolecule modification#GO:0043412;alcohol biosynthetic process#GO:0046165;protein modification process#GO:0036211;organic hydroxy compound biosynthetic process#GO:1901617;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;organic hydroxy compound metabolic process#GO:1901615;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein glycosylation#GO:0006486;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;alcohol metabolic process#GO:0006066;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;isoprenoid metabolic process#GO:0006720;isoprenoid biosynthetic process#GO:0008299;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;small molecule biosynthetic process#GO:0044283;cellular lipid metabolic process#GO:0044255;glycosylation#GO:0070085;small molecule metabolic process#GO:0044281 intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG189136|UniProtKB=T1FQP9 T1FQP9 20211146 PTHR10891:SF918 EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN CALCIUM-BINDING PROTEIN 2 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG187932|UniProtKB=T1FPH4 T1FPH4 20210721 PTHR11905:SF159 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG88417|UniProtKB=T1G722 T1G722 20216869 PTHR12765:SF5 RED PROTEIN IK FACTOR CYTOKINE IK PROTEIN RED cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytokine#PC00083 HELRO|EnsemblGenome=HelroG94681|UniProtKB=T1G923 T1G923 20217570 PTHR24322:SF736 PKSB RETINOL DEHYDROGENASE 10 oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG151168|UniProtKB=T1EKI6 T1EKI6 20197086 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG106408|UniProtKB=T1EE25 T1EE25 20194827 PTHR19376:SF32 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1 catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;RNA polymerase activity#GO:0097747;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG179786|UniProtKB=T1FF56 T1FF56 20207455 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG121032|UniProtKB=T1EGQ9 T1EGQ9 20195759 PTHR48102:SF7 ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887;pyrophosphatase activity#GO:0016462;ATP-dependent activity#GO:0140657;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;anion binding#GO:0043168;ion binding#GO:0043167;ATP binding#GO:0005524 macromolecule catabolic process#GO:0009057;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;proteolysis#GO:0006508;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;catabolic process#GO:0009056;organonitrogen compound catabolic process#GO:1901565;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;primary metabolic process#GO:0044238 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG108932|UniProtKB=T1EEP0 T1EEP0 20195042 PTHR45983:SF2 TYROSINE PHOSPHATSE N18, PUTATIVE-RELATED PROTEIN-TYROSINE-PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;dephosphorylation#GO:0016311;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG187087|UniProtKB=T1FP67 T1FP67 20210614 PTHR11158:SF29 MSF1/PX19 RELATED PRELI DOMAIN-CONTAINING PROTEIN 1, MITOCHONDRIAL phospholipid transporter activity#GO:0005548;lipid transfer activity#GO:0120013;transporter activity#GO:0005215;lipid transporter activity#GO:0005319 localization#GO:0051179;organic substance transport#GO:0071702;organophosphate ester transport#GO:0015748;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;lipid localization#GO:0010876;phospholipid transport#GO:0015914;lipid transport#GO:0006869 envelope#GO:0031975;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;mitochondrial envelope#GO:0005740;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;mitochondrial intermembrane space#GO:0005758;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG161965|UniProtKB=T1ES35 T1ES35 20199385 PTHR11139:SF9 ATAXIA TELANGIECTASIA MUTATED ATM -RELATED SERINE_THREONINE-PROTEIN KINASE MTOR transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 negative regulation of cellular metabolic process#GO:0031324;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;negative regulation of biological process#GO:0048519;regulation of catabolic process#GO:0009894;regulation of autophagy#GO:0010506;negative regulation of cellular catabolic process#GO:0031330;regulation of macroautophagy#GO:0016241;negative regulation of metabolic process#GO:0009892;cell communication#GO:0007154;negative regulation of autophagy#GO:0010507;regulation of cellular catabolic process#GO:0031329;negative regulation of macroautophagy#GO:0016242;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;negative regulation of catabolic process#GO:0009895;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;intracellular signal transduction#GO:0035556;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;regulation of metabolic process#GO:0019222;TOR signaling#GO:0031929;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Hypoxia response via HIF activation#P00030>TOR#P00817;p53 pathway by glucose deprivation#P04397>mTOR#P04638;Interleukin signaling pathway#P00036>mTOR#P00966;PDGF signaling pathway#P00047>mTOR#P01144 HELRO|EnsemblGenome=HelroG159004|UniProtKB=T1ENH2 T1ENH2 20198122 PTHR15021:SF0 DISCONNECTED-RELATED DISCO-RELATED, ISOFORM A-RELATED regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG193466|UniProtKB=T1FV09 T1FV09 20212655 PTHR45632:SF17 LD33804P KELCH-LIKE PROTEIN 31 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG80095|UniProtKB=T1G3X7 T1G3X7 20215775 PTHR18945:SF784 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 1 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;localization#GO:0051179;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 membrane protein complex#GO:0098796;synapse#GO:0045202;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron projection#GO:0043005;transmembrane transporter complex#GO:1902495;cell projection#GO:0042995;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 Nicotinic acetylcholine receptor signaling pathway#P00044>beta#P01095;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HELRO|EnsemblGenome=HelroG185724|UniProtKB=T1FN72 T1FN72 20210270 PTHR22957:SF686 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN GROWTH HORMONE-REGULATED TBC PROTEIN 1 nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;activation of GTPase activity#GO:0090630;biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG192604|UniProtKB=T1FU43 T1FU43 20212339 PTHR19872:SF7 UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN F-BOX AND WD REPEAT DOMAIN CONTAINING PROTEIN 10B-RELATED ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185683|UniProtKB=T1FN52 T1FN52 20210250 PTHR19282:SF562 TETRASPANIN AT12771P-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG152761|UniProtKB=T1EKW7 T1EKW7 20197217 PTHR43215:SF14 RADIAL SPOKE HEAD 1 HOMOLOG RADIAL SPOKE HEAD 1 HOMOLOG HELRO|EnsemblGenome=HelroG160566|UniProtKB=T1EQF4 T1EQF4 20198804 PTHR21258:SF56 DOCKING PROTEIN RELATED IRS-TYPE PTB DOMAIN-CONTAINING PROTEIN regulation of biological process#GO:0050789;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG119050|UniProtKB=T1EGM4 T1EGM4 20195724 PTHR45628:SF7 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated calcium channel activity#GO:0005245;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;calcium ion transport#GO:0006816;localization#GO:0051179;calcium ion import#GO:0070509;import across plasma membrane#GO:0098739;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;calcium ion transmembrane import into cytosol#GO:0097553;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657 voltage-gated calcium channel complex#GO:0005891;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;calcium channel complex#GO:0034704;membrane#GO:0016020;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 Ionotropic glutamate receptor pathway#P00037>Ca2+ channel#P01022;Thyrotropin-releasing hormone receptor signaling pathway#P04394>Ca2+ channel#P04587;Metabotropic glutamate receptor group II pathway#P00040>Ca2+#P01051;Metabotropic glutamate receptor group III pathway#P00039>Ca2+#P01041 HELRO|EnsemblGenome=HelroG192974|UniProtKB=T1FUH0 T1FUH0 20212466 PTHR11592:SF134 GLUTATHIONE PEROXIDASE PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;antioxidant activity#GO:0016209;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 peroxidase#PC00180;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG158191|UniProtKB=T1EMK2 T1EMK2 20197802 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG170827|UniProtKB=T1F3H2 T1F3H2 20203371 PTHR35711:SF1 EXPRESSED PROTEIN ECTODERMAL, ISOFORM F HELRO|EnsemblGenome=HelroG184651|UniProtKB=T1FLP1 T1FLP1 20209740 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG72453|UniProtKB=T1G104 T1G104 20214752 PTHR24637:SF388 COLLAGEN NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158315|UniProtKB=T1EMM9 T1EMM9 20197829 PTHR13802:SF52 MUCIN 4-RELATED MUCIN-4 HELRO|EnsemblGenome=HelroG100690|UniProtKB=T1ED13 T1ED13 20194465 PTHR16172:SF2 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG163238|UniProtKB=T1ETT7 T1ETT7 20199987 PTHR28653:SF1 FAMILY NOT NAMED ATPASE SWSAP1 HELRO|EnsemblGenome=HelroG113643|UniProtKB=T1EFU6 T1EFU6 20195448 PTHR47958:SF90 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE DDX5-RELATED catalytic activity, acting on RNA#GO:0140098;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640;mRNA binding#GO:0003729 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;alternative mRNA splicing, via spliceosome#GO:0000380;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;mRNA splicing, via spliceosome#GO:0000398;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG158679|UniProtKB=T1EN43 T1EN43 20197993 PTHR33395:SF21 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED PERICARDIN heart morphogenesis#GO:0003007;system development#GO:0048731;heart development#GO:0007507;circulatory system development#GO:0072359;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;animal organ development#GO:0048513;multicellular organism development#GO:0007275;developmental process#GO:0032502;animal organ morphogenesis#GO:0009887;multicellular organismal process#GO:0032501;cell adhesion#GO:0007155;cellular process#GO:0009987;post-embryonic development#GO:0009791 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG179563|UniProtKB=T1FEV6 T1FEV6 20207355 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185703|UniProtKB=T1FN61 T1FN61 20210259 PTHR12399:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D nucleic acid binding#GO:0003676;translation regulator activity#GO:0045182;translation regulator activity, nucleic acid binding#GO:0090079;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation initiation factor activity#GO:0003743;translation factor activity, RNA binding#GO:0008135 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;translational initiation#GO:0006413;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;eukaryotic translation initiation factor 3 complex#GO:0005852;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG78193|UniProtKB=T1G392 T1G392 20215540 PTHR45832:SF22 SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED HELRO|EnsemblGenome=HelroG68497|UniProtKB=T1FZF8 T1FZF8 20214206 PTHR22808:SF1 NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED methyltransferase activity#GO:0008168;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;methylation#GO:0032259;macromolecule methylation#GO:0043414;nitrogen compound metabolic process#GO:0006807;RNA methylation#GO:0001510;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG122480|UniProtKB=T1EGU7 T1EGU7 20195797 PTHR45775:SF6 RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C HELRO|EnsemblGenome=HelroG79507|UniProtKB=T1G3P5 T1G3P5 20215693 PTHR48092:SF9 KNIRPS-RELATED PROTEIN-RELATED KNIRPS-RELATED PROTEIN-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG176697|UniProtKB=T1FAS7 T1FAS7 20205926 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191215|UniProtKB=T1FSR0 T1FSR0 20211857 PTHR10654:SF18 CAS SCAFFOLDING PROTEIN IP17195P regulation of biological process#GO:0050789;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;cell communication#GO:0007154;cell motility#GO:0048870;cellular process#GO:0009987;cell migration#GO:0016477;signaling#GO:0023052;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG168365|UniProtKB=T1F0H4 T1F0H4 20202324 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG169388|UniProtKB=T1F1V8 T1F1V8 20202808 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG156333|UniProtKB=T1ELT9 T1ELT9 20197539 PTHR43294:SF13 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium ion transmembrane transporter activity#GO:0015079;sodium ion transmembrane transporter activity#GO:0015081;P-type ion transporter activity#GO:0015662;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075 inorganic ion homeostasis#GO:0098771;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;proton transmembrane transport#GO:1902600;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;sodium ion homeostasis#GO:0055078;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;import into cell#GO:0098657;monoatomic cation transmembrane transport#GO:0098655;export from cell#GO:0140352;sodium ion transmembrane transport#GO:0035725;potassium ion import across plasma membrane#GO:1990573;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG85991|UniProtKB=T1G657 T1G657 20216554 PTHR10460:SF0 ABL INTERACTOR FAMILY MEMBER ABELSON INTERACTING PROTEIN, ISOFORM D scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG102529|UniProtKB=T1EDA0 T1EDA0 20194552 PTHR43721:SF11 ELONGATION FACTOR TU-RELATED SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR nucleic acid binding#GO:0003676;translation regulator activity#GO:0045182;translation regulator activity, nucleic acid binding#GO:0090079;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation elongation factor activity#GO:0003746;translation factor activity, RNA binding#GO:0008135 regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;peptide metabolic process#GO:0006518;gene expression#GO:0010467;biosynthetic process#GO:0009058;translation#GO:0006412;regulation of biological process#GO:0050789;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;cellular nitrogen compound biosynthetic process#GO:0044271;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;regulation of primary metabolic process#GO:0080090;peptide biosynthetic process#GO:0043043;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of translation#GO:0006417;translational elongation#GO:0006414;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 translation elongation factor#PC00222;translational protein#PC00263 HELRO|EnsemblGenome=HelroG190700|UniProtKB=T1FS77 T1FS77 20211674 PTHR15907:SF182 DUF614 FAMILY PROTEIN-RELATED PROTEIN PLANT CADMIUM RESISTANCE 1-RELATED HELRO|EnsemblGenome=HelroG104176|UniProtKB=T1EDK0 T1EDK0 20194652 PTHR13140:SF745 MYOSIN UNCONVENTIONAL MYOSIN-VI microfilament motor activity#GO:0000146;cytoskeletal protein binding#GO:0008092;ATP-dependent activity#GO:0140657;binding#GO:0005488;actin filament binding#GO:0051015;cytoskeletal motor activity#GO:0003774;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;actin filament-based movement#GO:0030048;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;cytoskeleton#GO:0005856;plasma membrane#GO:0005886 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG194925|UniProtKB=T1FWK7 T1FWK7 20213202 PTHR12450:SF22 DENTIN MATRIX PROTEIN 4 PROTEIN FAM20 EXTRACELLULAR SERINE_THREONINE PROTEIN CG31145 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG72662|UniProtKB=T1G135 T1G135 20214783 PTHR24044:SF506 NOTCH LIGAND FAMILY MEMBER NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2-LIKE protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG97596|UniProtKB=T1G9H8 T1G9H8 20217725 PTHR10075:SF100 BASIGIN RELATED FASCICLIN-2 cell adhesion molecule binding#GO:0050839;cell-cell adhesion mediator activity#GO:0098632;protein binding#GO:0005515;binding#GO:0005488 neuron projection guidance#GO:0097485;cell recognition#GO:0008037;neurogenesis#GO:0022008;cell projection organization#GO:0030030;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;axonogenesis#GO:0007409;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156;cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cell morphogenesis#GO:0000902;cellular process#GO:0009987;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure development#GO:0048856;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;axon#GO:0030424 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG156207|UniProtKB=T1ELS7 T1ELS7 20197527 PTHR24068:SF144 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 C-RELATED ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 regulation of chromosome segregation#GO:0051983;macromolecule modification#GO:0043412;protein catabolic process#GO:0030163;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;regulation of cellular component organization#GO:0051128;post-translational protein modification#GO:0043687;regulation of biological process#GO:0050789;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;regulation of chromosome organization#GO:0033044;macromolecule catabolic process#GO:0009057;protein ubiquitination#GO:0016567;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation or removal#GO:0070647;regulation of mitotic cell cycle phase transition#GO:1901990;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;regulation of organelle organization#GO:0033043;regulation of cell cycle phase transition#GO:1901987;organonitrogen compound metabolic process#GO:1901564;regulation of mitotic metaphase/anaphase transition#GO:0030071;regulation of cell cycle process#GO:0010564;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;anaphase-promoting complex-dependent catabolic process#GO:0031145;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;regulation of sister chromatid segregation#GO:0033045;regulation of mitotic cell cycle#GO:0007346 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E2#P01491 HELRO|EnsemblGenome=HelroG155914|UniProtKB=T1ELP2 T1ELP2 20197492 PTHR12817:SF0 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B GEO08327P1 localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193 trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;vesicle tethering complex#GO:0099023;TRAPP complex#GO:0030008;Golgi apparatus#GO:0005794;organelle subcompartment#GO:0031984;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cis-Golgi network#GO:0005801;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791 HELRO|EnsemblGenome=HelroG63042|UniProtKB=T1FXA1 T1FXA1 20213449 PTHR11157:SF126 FATTY ACID ACYL TRANSFERASE-RELATED ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;monocarboxylic acid biosynthetic process#GO:0072330;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;organic acid metabolic process#GO:0006082;membrane lipid biosynthetic process#GO:0046467;sphingolipid metabolic process#GO:0006665;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;fatty acid metabolic process#GO:0006631;membrane lipid metabolic process#GO:0006643;nitrogen compound metabolic process#GO:0006807;small molecule biosynthetic process#GO:0044283;cellular lipid metabolic process#GO:0044255;carboxylic acid metabolic process#GO:0019752;sphingolipid biosynthetic process#GO:0030148;fatty acid biosynthetic process#GO:0006633;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG168134|UniProtKB=T1F075 T1F075 20202225 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG193729|UniProtKB=T1FVA8 T1FVA8 20212754 PTHR15832:SF2 SHC (SRC HOMOLOGY DOMAIN C-TERMINAL) ADAPTOR HOMOLOG SH2 DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG91562|UniProtKB=T1G855 T1G855 20217252 PTHR44490:SF1 EUKARYOTIC TRANSLATION ELONGATION FACTOR 1 EPSILON-1 EUKARYOTIC TRANSLATION ELONGATION FACTOR 1 EPSILON-1 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 translation elongation factor#PC00222;translational protein#PC00263 HELRO|EnsemblGenome=HelroG189191|UniProtKB=T1FQR6 T1FQR6 20211163 PTHR31437:SF1 SREK1IP1 FAMILY MEMBER PROTEIN SREK1IP1 HELRO|EnsemblGenome=HelroG166102|UniProtKB=T1EXR7 T1EXR7 20201367 PTHR43128:SF16 L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)) L-LACTATE DEHYDROGENASE oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 organic hydroxy compound metabolic process#GO:1901615;oxoacid metabolic process#GO:0043436;cellular metabolic process#GO:0044237;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG181394|UniProtKB=T1FGY7 T1FGY7 20208086 PTHR24064:SF577 SOLUTE CARRIER FAMILY 22 MEMBER GH09241P secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG188682|UniProtKB=T1FQ90 T1FQ90 20210987 PTHR46641:SF25 FMRFAMIDE RECEPTOR-RELATED CNMAMIDE RECEPTOR-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG154942|UniProtKB=T1ELG5 T1ELG5 20197415 PTHR19139:SF199 AQUAPORIN TRANSPORTER MIP17260P cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG159138|UniProtKB=T1ENN1 T1ENN1 20198181 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG194657|UniProtKB=T1FWA3 T1FWA3 20213099 PTHR10231:SF106 NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER UDP-GALACTOSE TRANSLOCATOR transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 cytoplasm#GO:0005737;bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG62071|UniProtKB=T1FWV2 T1FWV2 20213300 PTHR10937:SF0 GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING) transaminase activity#GO:0008483;transferase activity#GO:0016740;catalytic activity#GO:0003824 glycoprotein biosynthetic process#GO:0009101;cellular aromatic compound metabolic process#GO:0006725;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule modification#GO:0043412;protein modification process#GO:0036211;biosynthetic process#GO:0009058;nucleotide-sugar metabolic process#GO:0009225;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein glycosylation#GO:0006486;UDP-N-acetylglucosamine metabolic process#GO:0006047;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;protein N-linked glycosylation#GO:0006487;amino sugar metabolic process#GO:0006040;organophosphate metabolic process#GO:0019637;nucleobase-containing small molecule metabolic process#GO:0055086;glycosylation#GO:0070085;small molecule metabolic process#GO:0044281 transaminase#PC00216 O-antigen biosynthesis#P02757>Fructose-6-phosphate aminotransferase#P03051;N-acetylglucosamine metabolism#P02756>Fructose-6-phosphate aminotransferase#P03042;De novo purine biosynthesis#P02738>Amidophosphoribosyl transferase#P02905 HELRO|EnsemblGenome=HelroG192969|UniProtKB=T1FUG9 T1FUG9 20212465 PTHR24393:SF15 ZINC FINGER PROTEIN IP01243P-RELATED DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG153328|UniProtKB=T1EL40 T1EL40 20197290 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG63739|UniProtKB=T1FXJ4 T1FXJ4 20213542 PTHR10024:SF369 SYNAPTOTAGMIN FI18813P1 cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;phosphatidylserine binding#GO:0001786;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;protein binding#GO:0005515;clathrin binding#GO:0030276;lipid binding#GO:0008289;ion binding#GO:0043167;phospholipid binding#GO:0005543;SNARE binding#GO:0000149 vesicle fusion#GO:0006906;cellular localization#GO:0051641;synaptic vesicle cycle#GO:0099504;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;regulated exocytosis#GO:0045055;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;secretion#GO:0046903;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;signal release#GO:0023061;vesicle organization#GO:0016050;calcium-ion regulated exocytosis#GO:0017156;signaling#GO:0023052;cell-cell signaling#GO:0007267;synaptic vesicle exocytosis#GO:0016079;organelle fusion#GO:0048284;secretion by cell#GO:0032940;neurotransmitter secretion#GO:0007269;trans-synaptic signaling#GO:0099537;vesicle-mediated transport#GO:0016192;cell communication#GO:0007154;cellular component organization#GO:0016043;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;membrane fusion#GO:0061025;signal release from synapse#GO:0099643;exocytosis#GO:0006887;organelle organization#GO:0006996;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;export from cell#GO:0140352;vesicle-mediated transport in synapse#GO:0099003 synapse#GO:0045202;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;axon#GO:0030424;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;neuron projection#GO:0043005;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;transport vesicle#GO:0030133;cell projection#GO:0042995;secretory vesicle#GO:0099503;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG171365|UniProtKB=T1F466 T1F466 20203615 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182112|UniProtKB=T1FHS0 T1FHS0 20208369 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171767|UniProtKB=T1F4M7 T1F4M7 20203776 PTHR10334:SF554 CYSTEINE-RICH SECRETORY PROTEIN-RELATED AT04879P-RELATED extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG84168|UniProtKB=T1G5F8 T1G5F8 20216305 PTHR10072:SF41 IRON-SULFUR CLUSTER ASSEMBLY PROTEIN IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL small molecule binding#GO:0036094;binding#GO:0005488;iron-sulfur cluster binding#GO:0051536 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;iron-sulfur cluster assembly#GO:0016226;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG154361|UniProtKB=T1ELE6 T1ELE6 20197396 PTHR10681:SF128 THIOREDOXIN PEROXIDASE THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;antioxidant activity#GO:0016209;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;response to stress#GO:0006950;catabolic process#GO:0009056;cellular metabolic process#GO:0044237;homeostatic process#GO:0042592;response to oxidative stress#GO:0006979;cellular process#GO:0009987;cellular response to stress#GO:0033554;cellular homeostasis#GO:0019725;cellular catabolic process#GO:0044248;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 peroxidase#PC00180;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG192410|UniProtKB=T1FTX5 T1FTX5 20212272 PTHR17920:SF3 TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4 TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 HELRO|EnsemblGenome=HelroG77720|UniProtKB=T1G331 T1G331 20215479 PTHR11636:SF89 POU DOMAIN POU DOMAIN PROTEIN 2, ISOFORM B-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG183217|UniProtKB=T1FJB8 T1FJB8 20208917 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG184232|UniProtKB=T1FKT3 T1FKT3 20209432 PTHR12241:SF161 TUBULIN POLYGLUTAMYLASE TUBULIN POLYGLUTAMYLASE TTLL6 cytoskeletal protein binding#GO:0008092;ligase activity#GO:0016874;protein binding#GO:0005515;tubulin binding#GO:0015631;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;microtubule cytoskeleton organization#GO:0000226;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;cellular component organization#GO:0016043;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;nitrogen compound metabolic process#GO:0006807;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;cilium#GO:0005929;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG185116|UniProtKB=T1FME9 T1FME9 20209998 PTHR10949:SF0 LIPOYL SYNTHASE LIPOYL SYNTHASE, MITOCHONDRIAL Lipoate_biosynthesis#P02750>Lipoate synthase#P03004 HELRO|EnsemblGenome=HelroG173329|UniProtKB=T1F6P3 T1F6P3 20204492 PTHR13578:SF20 ADDITIONAL SEX COMBS LIKE PROTEIN ASXL POLYCOMB PROTEIN ASX protein-containing complex binding#GO:0044877;binding#GO:0005488;chromatin binding#GO:0003682 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;animal organ development#GO:0048513;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;anatomical structure morphogenesis#GO:0009653;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;regulation of DNA-templated transcription#GO:0006355;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;biological regulation#GO:0065007;animal organ morphogenesis#GO:0009887;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 PcG protein complex#GO:0031519;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG191643|UniProtKB=T1FT59 T1FT59 20212006 PTHR34487:SF1 ACYL-ACP THIOESTERASE ACYL-ACP THIOESTERASE HELRO|EnsemblGenome=HelroG78878|UniProtKB=T1G3G6 T1G3G6 20215614 PTHR11157:SF17 FATTY ACID ACYL TRANSFERASE-RELATED ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 6 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;monocarboxylic acid biosynthetic process#GO:0072330;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;organic acid metabolic process#GO:0006082;membrane lipid biosynthetic process#GO:0046467;sphingolipid metabolic process#GO:0006665;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;fatty acid metabolic process#GO:0006631;membrane lipid metabolic process#GO:0006643;nitrogen compound metabolic process#GO:0006807;small molecule biosynthetic process#GO:0044283;cellular lipid metabolic process#GO:0044255;carboxylic acid metabolic process#GO:0019752;sphingolipid biosynthetic process#GO:0030148;fatty acid biosynthetic process#GO:0006633;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG172114|UniProtKB=T1F517 T1F517 20203916 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG66108|UniProtKB=T1FYH1 T1FYH1 20213869 PTHR11206:SF153 MULTIDRUG RESISTANCE PROTEIN ETHIONINE RESISTANCE-CONFERRING PROTEIN 1 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG185502|UniProtKB=T1FMW5 T1FMW5 20210164 PTHR43563:SF14 AMINE OXIDASE AMINE OXIDASE oxidase#PC00175;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG81738|UniProtKB=T1G4I2 T1G4I2 20215980 PTHR43757:SF16 AMINOMETHYLTRANSFERASE AMINOMETHYLTRANSFERASE, MITOCHONDRIAL cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG176619|UniProtKB=T1FAQ7 T1FAQ7 20205906 PTHR20916:SF18 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN IPT_TIG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182105|UniProtKB=T1FHR6 T1FHR6 20208365 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169063|UniProtKB=T1F1C7 T1F1C7 20202627 PTHR45710:SF26 C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 180 RH26557P defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG112195|UniProtKB=T1EFH6 T1EFH6 20195328 PTHR24409:SF418 ZINC FINGER PROTEIN 142 SI:CH73-221F6.1 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG135208|UniProtKB=T1EI73 T1EI73 20196273 PTHR47979:SF53 DRAB11-RELATED FI07418P GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;transport#GO:0006810 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG82191|UniProtKB=T1G4P0 T1G4P0 20216038 PTHR12619:SF33 RFX TRANSCRIPTION FACTOR FAMILY RFX, ISOFORM H sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG161356|UniProtKB=T1ERD9 T1ERD9 20199139 PTHR10829:SF25 CORTACTIN AND DREBRIN DREBRIN-LIKE PROTEIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 regulation of anatomical structure size#GO:0090066;regulation of actin filament length#GO:0030832;regulation of organelle organization#GO:0033043;regulation of actin filament organization#GO:0110053;regulation of cellular component organization#GO:0051128;cellular component organization#GO:0016043;regulation of actin polymerization or depolymerization#GO:0008064;cellular process#GO:0009987;regulation of actin filament polymerization#GO:0030833;regulation of cellular component size#GO:0032535;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cytoskeleton organization#GO:0051493;regulation of protein-containing complex assembly#GO:0043254;regulation of biological quality#GO:0065008;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament-based process#GO:0032970;regulation of protein polymerization#GO:0032271 supramolecular complex#GO:0099080;cortical cytoskeleton#GO:0030863;supramolecular polymer#GO:0099081;cellular anatomical entity#GO:0110165;cell cortex#GO:0005938;cell periphery#GO:0071944;supramolecular fiber#GO:0099512;cortical actin cytoskeleton#GO:0030864;organelle#GO:0043226;actin filament#GO:0005884;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG171983|UniProtKB=T1F4W9 T1F4W9 20203868 PTHR31802:SF50 32 KDA HEAT SHOCK PROTEIN-RELATED DEATH DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG62468|UniProtKB=T1FX12 T1FX12 20213360 PTHR10106:SF0 CYTOCHROME B561-RELATED LD36721P oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 reductase#PC00198;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG182829|UniProtKB=T1FIT6 T1FIT6 20208735 PTHR11360:SF260 MONOCARBOXYLATE TRANSPORTER MFS DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;monocarboxylic acid transmembrane transporter activity#GO:0008028;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;monocarboxylic acid transport#GO:0015718;establishment of localization#GO:0051234;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942 transporter#PC00227 HELRO|EnsemblGenome=HelroG171479|UniProtKB=T1F4C4 T1F4C4 20203673 PTHR34718:SF2 PHD-TYPE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77768|UniProtKB=T1G337 T1G337 20215485 PTHR20900:SF0 NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transporter complex#GO:1990351;oxidoreductase complex#GO:1990204;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;respirasome#GO:0070469;mitochondrial respiratory chain complex I#GO:0005747;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;transmembrane transporter complex#GO:1902495;mitochondrial respirasome#GO:0005746;membrane-bounded organelle#GO:0043227;respiratory chain complex I#GO:0045271;NADH dehydrogenase complex#GO:0030964;mitochondrial protein-containing complex#GO:0098798 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG78123|UniProtKB=T1G384 T1G384 20215532 PTHR47958:SF103 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE DDX41-RELATED catalytic activity, acting on RNA#GO:0140098;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640;mRNA binding#GO:0003729 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;mRNA splicing, via spliceosome#GO:0000398;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG188231|UniProtKB=T1FPS8 T1FPS8 20210825 PTHR17613:SF14 CEREBRAL PROTEIN-11-RELATED DEMENTIN, ISOFORM H cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG74592|UniProtKB=T1G1T1 T1G1T1 20215029 PTHR24243:SF208 G-PROTEIN COUPLED RECEPTOR PYROKININ-1 RECEPTOR G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG107375|UniProtKB=T1EEA3 T1EEA3 20194905 PTHR21266:SF32 IRON-SULFUR DOMAIN CONTAINING PROTEIN CHOLESTEROL 7-DESATURASE NVD oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG187732|UniProtKB=T1FPC3 T1FPC3 20210670 PTHR11728:SF8 GLYCEROL-3-PHOSPHATE DEHYDROGENASE GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;carbohydrate derivative metabolic process#GO:1901135;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;pyridine nucleotide metabolic process#GO:0019362;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;glycerol-3-phosphate metabolic process#GO:0006072;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG191968|UniProtKB=T1FTG7 T1FTG7 20212114 PTHR32083:SF0 CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 structural protein#PC00211 HELRO|EnsemblGenome=HelroG77531|UniProtKB=T1G2Z4 T1G2Z4 20215442 PTHR19229:SF250 ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;lipid transporter activity#GO:0005319;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;organic substance transport#GO:0071702;lipid localization#GO:0010876;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;lipid transport#GO:0006869;transport#GO:0006810 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG190307|UniProtKB=T1FRW0 T1FRW0 20211557 PTHR22605:SF16 RZ-TYPE DOMAIN-CONTAINING PROTEIN E3 UBIQUITIN-PROTEIN LIGASE RNF213 HELRO|EnsemblGenome=HelroG107328|UniProtKB=T1EE96 T1EE96 20194898 PTHR12276:SF115 EPSIN/ENT-RELATED FI19443P1 protein binding#GO:0005515;lipid binding#GO:0008289;clathrin binding#GO:0030276;phospholipid binding#GO:0005543;binding#GO:0005488 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;import into cell#GO:0098657;transport#GO:0006810;endocytosis#GO:0006897 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;clathrin vesicle coat#GO:0030125;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;vesicle coat#GO:0030120;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;clathrin-coated vesicle#GO:0030136;endomembrane system#GO:0012505;membrane coat#GO:0030117;coated vesicle membrane#GO:0030662;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;coated membrane#GO:0048475;cytoplasmic vesicle membrane#GO:0030659;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG162745|UniProtKB=T1ET27 T1ET27 20199727 PTHR10032:SF271 ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS RH12261P-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG149039|UniProtKB=T1EKC3 T1EKC3 20197023 PTHR45623:SF11 CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED KISMET, ISOFORM C ATP-dependent activity, acting on DNA#GO:0008094;nucleic acid binding#GO:0003676;binding#GO:0005488;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887;histone binding#GO:0042393;pyrophosphatase activity#GO:0016462;ATP-dependent activity#GO:0140657;chromatin binding#GO:0003682;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity, acting on DNA#GO:0140097;protein-containing complex binding#GO:0044877 cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;protein-DNA complex organization#GO:0071824;cellular component organization#GO:0016043;cellular process#GO:0009987;chromatin remodeling#GO:0006338;protein-containing complex organization#GO:0043933 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG189995|UniProtKB=T1FRK6 T1FRK6 20211453 PTHR25465:SF31 B-BOX DOMAIN CONTAINING RING-TYPE DOMAIN-CONTAINING PROTEIN ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG69935|UniProtKB=T1G001 T1G001 20214399 PTHR10707:SF10 CYTOCHROME C OXIDASE SUBUNIT IV CYTOCHROME C OXIDASE SUBUNIT 4 mitochondrial ATP synthesis coupled electron transport#GO:0042775;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;respiratory electron transport chain#GO:0022904;aerobic electron transport chain#GO:0019646;oxidative phosphorylation#GO:0006119;generation of precursor metabolites and energy#GO:0006091;electron transport chain#GO:0022900;ATP synthesis coupled electron transport#GO:0042773;cellular metabolic process#GO:0044237;cellular process#GO:0009987;mitochondrial electron transport, cytochrome c to oxygen#GO:0006123;energy derivation by oxidation of organic compounds#GO:0015980;metabolic process#GO:0008152 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;cytochrome complex#GO:0070069;respiratory chain complex#GO:0098803;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;respirasome#GO:0070469;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;mitochondrial respirasome#GO:0005746;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;respiratory chain complex IV#GO:0045277;mitochondrial protein-containing complex#GO:0098798 oxidase#PC00175;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG178820|UniProtKB=T1FDS6 T1FDS6 20206975 PTHR11461:SF372 SERINE PROTEASE INHIBITOR, SERPIN ACCESSORY GLAND PROTEIN ACP76A-RELATED extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG110003|UniProtKB=T1EEY2 T1EEY2 20195134 PTHR45832:SF16 SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED SERINE_THREONINE-PROTEIN KINASE STE20-LIKE-RELATED HELRO|EnsemblGenome=HelroG169067|UniProtKB=T1F1C8 T1F1C8 20202628 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cell communication#GO:0007154;cellular process#GO:0009987;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;Notch signaling pathway#GO:0007219 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG177336|UniProtKB=T1FBI9 T1FBI9 20206188 PTHR10985:SF77 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED GH26014P sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of multicellular organismal process#GO:0051239;regulation of cell development#GO:0060284;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regionalization#GO:0003002;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of RNA biosynthetic process#GO:2001141;regulation of multicellular organismal development#GO:2000026;regulation of cell differentiation#GO:0045595;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of neurogenesis#GO:0050767;regulation of macromolecule metabolic process#GO:0060255;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;regulation of nervous system development#GO:0051960;biological regulation#GO:0065007;anterior/posterior pattern specification#GO:0009952;multicellular organismal process#GO:0032501;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;pattern specification process#GO:0007389;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG107371|UniProtKB=T1EEA2 T1EEA2 20194904 PTHR10768:SF0 60S RIBOSOMAL PROTEIN L37 RIBOSOMAL PROTEIN L37 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG174648|UniProtKB=T1F8C6 T1F8C6 20205075 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG184303|UniProtKB=T1FKY0 T1FKY0 20209479 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG114129|UniProtKB=T1EFZ3 T1EFZ3 20195495 PTHR10909:SF250 ELECTRON TRANSPORT OXIDOREDUCTASE PEROXISOMAL ACYL-COENZYME A OXIDASE 1 nucleotide binding#GO:0000166;fatty acid binding#GO:0005504;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;organic cyclic compound binding#GO:0097159;carboxylic acid binding#GO:0031406;nucleoside phosphate binding#GO:1901265;flavin adenine dinucleotide binding#GO:0050660;heterocyclic compound binding#GO:1901363;lipid binding#GO:0008289;anion binding#GO:0043168;ion binding#GO:0043167;organic acid binding#GO:0043177 oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;lipid oxidation#GO:0034440;cellular metabolic process#GO:0044237;homeostatic process#GO:0042592;lipid catabolic process#GO:0016042;lipid modification#GO:0030258;chemical homeostasis#GO:0048878;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;fatty acid catabolic process#GO:0009062;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;fatty acid metabolic process#GO:0006631;small molecule catabolic process#GO:0044282;fatty acid beta-oxidation#GO:0006635;lipid homeostasis#GO:0055088;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;carboxylic acid metabolic process#GO:0019752;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;microbody#GO:0042579;membrane-bounded organelle#GO:0043227;peroxisome#GO:0005777;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG147884|UniProtKB=T1EK33 T1EK33 20196934 PTHR23430:SF371 HISTONE H2A HISTONE H2A nucleosome binding#GO:0031491;nucleic acid binding#GO:0003676;chromatin DNA binding#GO:0031490;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;protein-containing complex binding#GO:0044877 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;protein-DNA complex organization#GO:0071824;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;heterochromatin formation#GO:0031507;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;negative regulation of gene expression, epigenetic#GO:0045814;cellular process#GO:0009987;epigenetic regulation of gene expression#GO:0040029;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;heterochromatin organization#GO:0070828;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG170489|UniProtKB=T1F344 T1F344 20203243 PTHR22742:SF2 EXPANSION, ISOFORM A-RELATED EXPANSION, ISOFORM A-RELATED HELRO|EnsemblGenome=HelroG63393|UniProtKB=T1FXF2 T1FXF2 20213500 PTHR10117:SF80 TRANSIENT RECEPTOR POTENTIAL CHANNEL TRANSIENT-RECEPTOR-POTENTIAL-LIKE PROTEIN calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;small molecule binding#GO:0036094;binding#GO:0005488;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;anion binding#GO:0043168;ion binding#GO:0043167;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;alcohol binding#GO:0043178 inorganic ion homeostasis#GO:0098771;fertilization#GO:0009566;calcium ion homeostasis#GO:0055074;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;single fertilization#GO:0007338;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;regulation of cytosolic calcium ion concentration#GO:0051480;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;calcium ion transport#GO:0006816;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;reproduction#GO:0000003;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;sexual reproduction#GO:0019953;reproductive process#GO:0022414;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG65991|UniProtKB=T1FYF7 T1FYF7 20213855 PTHR31247:SF5 TRANSMEMBRANE PROTEIN 198 FAMILY MEMBER DUF4203 DOMAIN-CONTAINING PROTEIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG158594|UniProtKB=T1EMZ7 T1EMZ7 20197947 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED BRCT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178238|UniProtKB=T1FCZ5 T1FCZ5 20206694 PTHR13484:SF10 FIP1-LIKE 1 PROTEIN SUBFAMILY NOT NAMED protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;mRNA cleavage factor complex#GO:0005849;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG188191|UniProtKB=T1FPR5 T1FPR5 20210812 PTHR23507:SF1 ZGC:174356 FI18259P1-RELATED Endothelin signaling pathway#P00019>Adenylate cyclase#P00569 HELRO|EnsemblGenome=HelroG182769|UniProtKB=T1FIP7 T1FIP7 20208696 PTHR46652:SF3 LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9 HELRO|EnsemblGenome=HelroG167028|UniProtKB=T1EYX2 T1EYX2 20201772 PTHR22748:SF6 AP ENDONUCLEASE DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE hydrolase activity, acting on ester bonds#GO:0016788;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;3'-5'-DNA exonuclease activity#GO:0008296;nuclease activity#GO:0004518;DNA exonuclease activity#GO:0004529;catalytic activity#GO:0003824;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097;phosphoric diester hydrolase activity#GO:0008081;exonuclease activity#GO:0004527;3'-5' exonuclease activity#GO:0008408;phosphoric ester hydrolase activity#GO:0042578 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;base-excision repair#GO:0006284;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 HELRO|EnsemblGenome=HelroG70208|UniProtKB=T1G033 T1G033 20214431 PTHR12952:SF0 SYS1 PROTEIN SYS1 HOMOLOG protein localization to plasma membrane#GO:0072659;Golgi to endosome transport#GO:0006895;localization within membrane#GO:0051668;cellular localization#GO:0051641;vesicle-mediated transport to the plasma membrane#GO:0098876;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;post-Golgi vesicle-mediated transport#GO:0006892;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;protein localization to Golgi apparatus#GO:0034067;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;cytosolic transport#GO:0016482;establishment of protein localization#GO:0045184;Golgi to plasma membrane transport#GO:0006893;protein localization#GO:0008104;localization#GO:0051179;protein localization to cell periphery#GO:1990778;organic substance transport#GO:0071702;establishment of protein localization to membrane#GO:0090150;Golgi to plasma membrane protein transport#GO:0043001;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365 bounding membrane of organelle#GO:0098588;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791;Golgi membrane#GO:0000139 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG71352|UniProtKB=T1G0K0 T1G0K0 20214598 PTHR14340:SF9 MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3 FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG187585|UniProtKB=T1FPA8 T1FPA8 20210655 PTHR13121:SF0 GPI TRANSAMIDASE COMPONENT PIG-U PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;phospholipid biosynthetic process#GO:0008654;macromolecule modification#GO:0043412;phosphatidylinositol biosynthetic process#GO:0006661;organophosphate biosynthetic process#GO:0090407;glycolipid metabolic process#GO:0006664;protein modification process#GO:0036211;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;glycerolipid biosynthetic process#GO:0045017;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;organic substance biosynthetic process#GO:1901576;liposaccharide metabolic process#GO:1903509;cellular process#GO:0009987;membrane lipid biosynthetic process#GO:0046467;GPI anchor metabolic process#GO:0006505;lipoprotein biosynthetic process#GO:0042158;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;GPI anchor biosynthetic process#GO:0006506;membrane lipid metabolic process#GO:0006643;glycerophospholipid biosynthetic process#GO:0046474;glycolipid biosynthetic process#GO:0009247;organophosphate metabolic process#GO:0019637;lipoprotein metabolic process#GO:0042157;cellular lipid metabolic process#GO:0044255 membrane protein complex#GO:0098796;peptidase complex#GO:1905368;endoplasmic reticulum protein-containing complex#GO:0140534;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endopeptidase complex#GO:1905369;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG177069|UniProtKB=T1FB73 T1FB73 20206072 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG79786|UniProtKB=T1G3T3 T1G3T3 20215731 PTHR11767:SF102 INWARD RECTIFIER POTASSIUM CHANNEL INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of localization#GO:0032879;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;import across plasma membrane#GO:0098739;regulation of transport#GO:0051049;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;regulation of monoatomic ion transport#GO:0043269;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;potassium ion transport#GO:0006813;potassium ion import across plasma membrane#GO:1990573 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG190406|UniProtKB=T1FRY7 T1FRY7 20211584 PTHR47634:SF9 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;macromolecule modification#GO:0043412;regulation of nitrogen compound metabolic process#GO:0051171;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of mRNA processing#GO:0050684;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;protein phosphorylation#GO:0006468;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;biological regulation#GO:0065007;mRNA processing#GO:0006397;peptidyl-serine modification#GO:0018209;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375;spliceosomal complex assembly#GO:0000245;regulation of metabolic process#GO:0019222;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323 HELRO|EnsemblGenome=HelroG185138|UniProtKB=T1FMG0 T1FMG0 20210009 PTHR46115:SF1 THIOREDOXIN-LIKE PROTEIN 1 AT08565P protein-disulfide reductase activity#GO:0015035;disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 Oxidative stress response#P00046>TRX#P01122;Hypoxia response via HIF activation#P00030>Thioredoxin#P00825 HELRO|EnsemblGenome=HelroG150398|UniProtKB=T1EKF6 T1EKF6 20197056 PTHR44899:SF3 CAMK FAMILY PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE NEK1 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG179222|UniProtKB=T1FED7 T1FED7 20207186 PTHR13551:SF1 BRAIN PROTEIN I3 MEMBRANE PROTEIN BRI3 HELRO|EnsemblGenome=HelroG184748|UniProtKB=T1FLX3 T1FLX3 20209822 PTHR43250:SF2 EXODEOXYRIBONUCLEASE III EXODEOXYRIBONUCLEASE III HELRO|EnsemblGenome=HelroG186249|UniProtKB=T1FNV2 T1FNV2 20210499 PTHR12966:SF0 NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13 NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transporter complex#GO:1990351;oxidoreductase complex#GO:1990204;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;respirasome#GO:0070469;mitochondrial respiratory chain complex I#GO:0005747;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;mitochondrial respirasome#GO:0005746;transmembrane transporter complex#GO:1902495;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;respiratory chain complex I#GO:0045271;NADH dehydrogenase complex#GO:0030964;mitochondrial protein-containing complex#GO:0098798 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG128645|UniProtKB=T1EHP7 T1EHP7 20196097 PTHR28562:SF1 COP9 SIGNALOSOME COMPLEX SUBUNIT 9 COP9 SIGNALOSOME COMPLEX SUBUNIT 9 regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;negative regulation of protein modification process#GO:0031400;negative regulation of biological process#GO:0048519;regulation of protein modification process#GO:0031399;regulation of protein metabolic process#GO:0051246;regulation of macromolecule metabolic process#GO:0060255;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of metabolic process#GO:0019222 HELRO|EnsemblGenome=HelroG77354|UniProtKB=T1G2W8 T1G2W8 20215416 PTHR46280:SF3 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 2-RELATED PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 1 HOMOLOG HELRO|EnsemblGenome=HelroG169679|UniProtKB=T1F279 T1F279 20202929 PTHR12766:SF7 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DEATH DOMAIN-ASSOCIATED PROTEIN 6 FAS signaling pathway#P00020>DAXX#P00602;Apoptosis signaling pathway#P00006>DAXX#P00296 HELRO|EnsemblGenome=HelroG168544|UniProtKB=T1F0P5 T1F0P5 20202395 PTHR11571:SF141 GLUTATHIONE S-TRANSFERASE GLUTATHIONE S-TRANSFERASE glutathione transferase activity#GO:0004364;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824 sulfur compound metabolic process#GO:0006790;nitrogen compound metabolic process#GO:0006807;peptide metabolic process#GO:0006518;cellular modified amino acid metabolic process#GO:0006575;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular process#GO:0009987;glutathione metabolic process#GO:0006749;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG175202|UniProtKB=T1F900 T1F900 20205299 PTHR23030:SF42 PCD6 INTERACTING PROTEIN-RELATED CHROMOSOME UNDETERMINED SCAFFOLD_90, WHOLE GENOME SHOTGUN SEQUENCE membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG103160|UniProtKB=T1EDE6 T1EDE6 20194598 PTHR42921:SF1 ACETOACETYL-COA SYNTHETASE ACETOACETYL-COA SYNTHETASE ligase activity#GO:0016874;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 ligase#PC00142 HELRO|EnsemblGenome=HelroG97989|UniProtKB=T1G9J8 T1G9J8 20217744 PTHR19918:SF1 CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED FIZZY-RELATED PROTEIN HOMOLOG protein-containing complex binding#GO:0044877;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;binding#GO:0005488 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of protein metabolic process#GO:0051246;regulation of catabolic process#GO:0009894;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of proteasomal protein catabolic process#GO:1901800;protein catabolic process#GO:0030163;organonitrogen compound catabolic process#GO:1901565;regulation of protein catabolic process#GO:0042176;regulation of proteolysis involved in protein catabolic process#GO:1903050;positive regulation of proteolysis#GO:0045862;modification-dependent macromolecule catabolic process#GO:0043632;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;positive regulation of biological process#GO:0048518;proteolysis involved in protein catabolic process#GO:0051603;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;regulation of proteolysis#GO:0030162;macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;positive regulation of proteolysis involved in protein catabolic process#GO:1903052;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;organonitrogen compound metabolic process#GO:1901564;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of proteasomal protein catabolic process#GO:0061136;regulation of primary metabolic process#GO:0080090;positive regulation of protein metabolic process#GO:0051247;anaphase-promoting complex-dependent catabolic process#GO:0031145;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;positive regulation of catabolic process#GO:0009896;positive regulation of protein catabolic process#GO:0045732;regulation of metabolic process#GO:0019222;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434 ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234;anaphase-promoting complex#GO:0005680;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG96873|UniProtKB=T1G9E1 T1G9E1 20217688 PTHR11099:SF0 VACUOLAR SORTING PROTEIN 35 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35 endosomal transport#GO:0016197;cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;cytosolic transport#GO:0016482;establishment of protein localization#GO:0045184;retrograde transport, endosome to Golgi#GO:0042147;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;late endosome#GO:0005770 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG185136|UniProtKB=T1FMF9 T1FMF9 20210008 PTHR10722:SF0 60S RIBOSOMAL PROTEIN L19 RIBOSOMAL PROTEIN L19 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG161701|UniProtKB=T1ERS8 T1ERS8 20199278 PTHR12684:SF2 PUTATIVE PHOSPHOTRANSFERASE TRNA 2'-PHOSPHOTRANSFERASE 1 catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG150560|UniProtKB=T1EKG0 T1EKG0 20197060 PTHR10264:SF130 BAND 7 PROTEIN-RELATED STOMATIN-LIKE PROTEIN 1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG194872|UniProtKB=T1FWI3 T1FWI3 20213178 PTHR11089:SF30 GTP-BINDING PROTEIN-RELATED GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG HELRO|EnsemblGenome=HelroG191066|UniProtKB=T1FSK0 T1FSK0 20211797 PTHR13817:SF171 TITIN STRETCHIN-MLCK, ISOFORM U structural protein#PC00211 HELRO|EnsemblGenome=HelroG109424|UniProtKB=T1EET7 T1EET7 20195089 PTHR43243:SF20 INNER MEMBRANE TRANSPORTER YGJI-RELATED CATIONIC AMINO ACID TRANSPORTER 3 transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;establishment of localization#GO:0051234;amino acid transport#GO:0006865;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;nitrogen compound transport#GO:0071705;carboxylic acid transport#GO:0046942 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 amino acid transporter#PC00046;transporter#PC00227 HELRO|EnsemblGenome=HelroG161093|UniProtKB=T1ER35 T1ER35 20199035 PTHR46512:SF10 PEPTIDYLPROLYL ISOMERASE FK506-BINDING PROTEIN-LIKE chaperone#PC00072 HELRO|EnsemblGenome=HelroG154543|UniProtKB=T1ELF0 T1ELF0 20197400 PTHR45721:SF12 LAMIN DM0-RELATED INTERMEDIATE FILAMENT PROTEIN IFA-1 structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;nuclear migration#GO:0007097;cellular localization#GO:0051641;negative regulation of biological process#GO:0048519;protein-DNA complex organization#GO:0071824;organelle localization#GO:0051640;macromolecule localization#GO:0033036;membrane organization#GO:0061024;transport#GO:0006810;protein localization to nucleus#GO:0034504;nucleus organization#GO:0006997;endomembrane system organization#GO:0010256;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;protein localization to organelle#GO:0033365;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;establishment of organelle localization#GO:0051656;negative regulation of cellular process#GO:0048523;localization within membrane#GO:0051668;negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;cellular process#GO:0009987;negative regulation of gene expression, epigenetic#GO:0045814;epigenetic regulation of gene expression#GO:0040029;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular macromolecule localization#GO:0070727;heterochromatin organization#GO:0070828;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;chromatin organization#GO:0006325;intracellular transport#GO:0046907;nuclear envelope organization#GO:0006998;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323;protein-containing complex localization#GO:0031503 membrane-enclosed lumen#GO:0031974;envelope#GO:0031975;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;nuclear periphery#GO:0034399;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981 HELRO|EnsemblGenome=HelroG178720|UniProtKB=T1FDM6 T1FDM6 20206925 PTHR20956:SF12 HEH2P FLYWCH-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG84138|UniProtKB=T1G5F2 T1G5F2 20216299 PTHR21162:SF0 P53 AND DNA DAMAGE-REGULATED PROTEIN P53 AND DNA DAMAGE-REGULATED PROTEIN 1 HELRO|EnsemblGenome=HelroG158228|UniProtKB=T1EMK9 T1EMK9 20197809 PTHR24098:SF0 OUTER SEGMENT 5 OUTER SEGMENT 5 organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 protein-containing complex#GO:0032991;intraciliary transport particle B#GO:0030992;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cilium#GO:0005929;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intraciliary transport particle#GO:0030990 HELRO|EnsemblGenome=HelroG78636|UniProtKB=T1G3D9 T1G3D9 20215587 PTHR12371:SF11 TRANSLOCATION ASSOCIATED MEMBRANE PROTEIN TRANSLOCATING CHAIN-ASSOCIATED MEMBRANE PROTEIN protein insertion into ER membrane#GO:0045048;localization within membrane#GO:0051668;cellular localization#GO:0051641;endoplasmic reticulum organization#GO:0007029;macromolecule localization#GO:0033036;membrane organization#GO:0061024;protein localization to membrane#GO:0072657;endomembrane system organization#GO:0010256;cellular component organization#GO:0016043;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to membrane#GO:0090150;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;organelle organization#GO:0006996;protein localization to organelle#GO:0033365;protein insertion into membrane#GO:0051205 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG75640|UniProtKB=T1G281 T1G281 20215179 PTHR14189:SF0 PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED PROTEIN PHOSPHATASE METHYLESTERASE 1 hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein modification process#GO:0036211;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;primary metabolic process#GO:0044238 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG63644|UniProtKB=T1FXI6 T1FXI6 20213534 PTHR31219:SF2 CHROMOSOME 28 C12ORF29 HOMOLOG RNA LIGASE 1 HELRO|EnsemblGenome=HelroG156619|UniProtKB=T1ELZ0 T1ELZ0 20197590 PTHR42861:SF127 CALCIUM-TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE SARCOPLASMIC_ENDOPLASMIC RETICULUM TYPE calcium ion transmembrane transporter activity#GO:0015085;inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;P-type ion transporter activity#GO:0015662;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;inorganic cation transmembrane transporter activity#GO:0022890;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;calcium ion transport#GO:0006816;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;membrane#GO:0016020 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG162362|UniProtKB=T1ESK3 T1ESK3 20199553 PTHR16200:SF1 RING ZINC FINGER E3 UBIQUITIN-PROTEIN LIGASE PLR-1-RELATED transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG161906|UniProtKB=T1ES10 T1ES10 20199360 PTHR22906:SF53 PROPERDIN HEMICENTIN-1 HELRO|EnsemblGenome=HelroG182787|UniProtKB=T1FIQ5 T1FIQ5 20208704 PTHR11521:SF1 TROPONIN T TROPONIN T, SKELETAL MUSCLE cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;binding#GO:0005488 cellular component biogenesis#GO:0044085;muscle cell differentiation#GO:0042692;system process#GO:0003008;developmental process#GO:0032502;myofibril assembly#GO:0030239;cellular anatomical entity morphogenesis#GO:0032989;muscle structure development#GO:0061061;striated muscle cell differentiation#GO:0051146;cell differentiation#GO:0030154;actin filament-based process#GO:0030029;anatomical structure morphogenesis#GO:0009653;supramolecular fiber organization#GO:0097435;striated muscle cell development#GO:0055002;cytoskeleton organization#GO:0007010;non-membrane-bounded organelle assembly#GO:0140694;sarcomere organization#GO:0045214;cellular developmental process#GO:0048869;cellular component assembly#GO:0022607;cellular component assembly involved in morphogenesis#GO:0010927;cellular component organization#GO:0016043;actomyosin structure organization#GO:0031032;cellular process#GO:0009987;anatomical structure formation involved in morphogenesis#GO:0048646;organelle assembly#GO:0070925;cell development#GO:0048468;muscle cell development#GO:0055001;cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;anatomical structure development#GO:0048856;multicellular organismal process#GO:0032501;actin cytoskeleton organization#GO:0030036;muscle system process#GO:0003012;muscle contraction#GO:0006936 supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;organelle#GO:0043226;contractile fiber#GO:0043292;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;sarcomere#GO:0030017;cytoskeleton#GO:0005856;myofibril#GO:0030016 cytoskeletal protein#PC00085;actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG166849|UniProtKB=T1EYM5 T1EYM5 20201675 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188761|UniProtKB=T1FQC1 T1FQC1 20211018 PTHR15730:SF5 EXPERIMENTAL AUTOIMMUNE PROSTATITIS ANTIGEN 2-RELATED SI:CH211-210B2.2-RELATED HELRO|EnsemblGenome=HelroG63410|UniProtKB=T1FXF5 T1FXF5 20213503 PTHR24343:SF345 SERINE/THREONINE KINASE TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 4 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191905|UniProtKB=T1FTE5 T1FTE5 20212092 PTHR24250:SF27 CHYMOTRYPSIN-RELATED ELASTASE 2 LIKE hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG163684|UniProtKB=T1EUC8 T1EUC8 20200178 PTHR45818:SF3 PROTEIN VAV PROTEIN VAV nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;regulation of GTPase activity#GO:0043087;regulation of molecular function#GO:0065009 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 PDGF signaling pathway#P00047>Vav#P01169 HELRO|EnsemblGenome=HelroG75424|UniProtKB=T1G250 T1G250 20215148 PTHR24355:SF18 G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE G PROTEIN-COUPLED RECEPTOR KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GPRK#P00741;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>GRK3#P05941;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GPRK#P00701;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Rhodopsin kinase#P00750;Parkinson disease#P00049>GRK#P01234 HELRO|EnsemblGenome=HelroG82544|UniProtKB=T1G4T5 T1G4T5 20216083 PTHR11767:SF102 INWARD RECTIFIER POTASSIUM CHANNEL INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of localization#GO:0032879;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;import across plasma membrane#GO:0098739;regulation of transport#GO:0051049;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;regulation of monoatomic ion transport#GO:0043269;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;potassium ion transport#GO:0006813;potassium ion import across plasma membrane#GO:1990573 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG165134|UniProtKB=T1EWB7 T1EWB7 20200867 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG173396|UniProtKB=T1F6S1 T1F6S1 20204520 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED FMRFAMIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG191240|UniProtKB=T1FSS2 T1FSS2 20211869 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG162327|UniProtKB=T1ESI4 T1ESI4 20199534 PTHR10217:SF637 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL EAG-LIKE K[+] CHANNEL, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG176969|UniProtKB=T1FB30 T1FB30 20206029 PTHR16021:SF26 MANSC DOMAIN CONTAINING PROTEIN 1 MANSC DOMAIN CONTAINING 4 HELRO|EnsemblGenome=HelroG195046|UniProtKB=T1FWP7 T1FWP7 20213242 PTHR13520:SF0 RAD50-INTERACTING PROTEIN 1 RINT-1 RAD50-INTERACTING PROTEIN 1 localization#GO:0051179;regulation of biological process#GO:0050789;regulation of transport#GO:0051049;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;transport#GO:0006810;biological regulation#GO:0065007;regulation of localization#GO:0032879;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;regulation of cellular localization#GO:0060341;regulation of vesicle-mediated transport#GO:0060627 cytoplasm#GO:0005737;endoplasmic reticulum protein-containing complex#GO:0140534;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;vesicle tethering complex#GO:0099023;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG95790|UniProtKB=T1G976 T1G976 20217623 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG193621|UniProtKB=T1FV69 T1FV69 20212715 PTHR10912:SF7 ADP-RIBOSYL CYCLASE ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE lyase activity#GO:0016829;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824 regulation of multicellular organismal process#GO:0051239;regulation of cell population proliferation#GO:0042127;positive regulation of cell population proliferation#GO:0008284;positive regulation of immune system process#GO:0002684;positive regulation of lymphocyte activation#GO:0051251;positive regulation of leukocyte activation#GO:0002696;positive regulation of cellular process#GO:0048522;regulation of cell activation#GO:0050865;regulation of biological process#GO:0050789;regulation of leukocyte activation#GO:0002694;regulation of mononuclear cell proliferation#GO:0032944;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of lymphocyte proliferation#GO:0050670;regulation of immune system process#GO:0002682;regulation of leukocyte proliferation#GO:0070663;positive regulation of cell activation#GO:0050867;regulation of lymphocyte activation#GO:0051249;positive regulation of biological process#GO:0048518;regulation of B cell proliferation#GO:0030888;positive regulation of multicellular organismal process#GO:0051240 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 cyclase#PC00079;lyase#PC00144 HELRO|EnsemblGenome=HelroG183750|UniProtKB=T1FK51 T1FK51 20209200 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG181286|UniProtKB=T1FGU5 T1FGU5 20208044 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191855|UniProtKB=T1FTD1 T1FTD1 20212078 PTHR10825:SF72 RING FINGER DOMAIN-CONTAINING, POLYCOMB GROUP COMPONENT UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN protein-containing complex binding#GO:0044877;binding#GO:0005488;chromatin binding#GO:0003682 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;PcG protein complex#GO:0031519;protein-containing complex#GO:0032991;PRC1 complex#GO:0035102;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG168545|UniProtKB=T1F0P6 T1F0P6 20202396 PTHR11571:SF141 GLUTATHIONE S-TRANSFERASE GLUTATHIONE S-TRANSFERASE glutathione transferase activity#GO:0004364;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824 sulfur compound metabolic process#GO:0006790;nitrogen compound metabolic process#GO:0006807;peptide metabolic process#GO:0006518;cellular modified amino acid metabolic process#GO:0006575;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular process#GO:0009987;glutathione metabolic process#GO:0006749;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG111522|UniProtKB=T1EFC1 T1EFC1 20195273 PTHR23151:SF90 DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED transferase#PC00220;acetyltransferase#PC00038;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG101913|UniProtKB=T1ED75 T1ED75 20194527 PTHR10519:SF77 GABA-B RECEPTOR GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 biological regulation#GO:0065007;regulation of biological process#GO:0050789;cell communication#GO:0007154;cellular process#GO:0009987;cell-cell signaling#GO:0007267;signaling#GO:0023052 receptor complex#GO:0043235;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 GABA-B receptor II signaling#P05731>GABA-B receptor#P05756 HELRO|EnsemblGenome=HelroG125208|UniProtKB=T1EH50 T1EH50 20195900 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG116619|UniProtKB=T1EGG6 T1EGG6 20195668 PTHR13954:SF6 IRE1-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE tyrosine protein kinase receptor#PC00233 Alzheimer disease-presenilin pathway#P00004>Ire-1#P00144;Alzheimer disease-presenilin pathway#P00004>Ire-1 N-terminal fragment#P00110;Alzheimer disease-presenilin pathway#P00004>Ire-1 C-terminal fragment#P00125 HELRO|EnsemblGenome=HelroG173705|UniProtKB=T1F751 T1F751 20204650 PTHR18952:SF141 CARBONIC ANHYDRASE CARBONIC ANHYDRASE carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG93529|UniProtKB=T1G8W3 T1G8W3 20217510 PTHR10841:SF17 SYNAPSIN SYNAPSIN neurotransmitter secretion#GO:0007269;cellular localization#GO:0051641;transport#GO:0006810;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;secretion#GO:0046903;neurotransmitter transport#GO:0006836;biological regulation#GO:0065007;signal release#GO:0023061;synaptic signaling#GO:0099536;establishment of localization in cell#GO:0051649;signaling#GO:0023052;cell-cell signaling#GO:0007267;export from cell#GO:0140352;secretion by cell#GO:0032940 synaptic vesicle membrane#GO:0030672;bounding membrane of organelle#GO:0098588;presynapse#GO:0098793;synapse#GO:0045202;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;cell junction#GO:0030054;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;transport vesicle membrane#GO:0030658;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;cytoplasmic vesicle membrane#GO:0030659;secretory vesicle#GO:0099503 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synapsin#P05775 HELRO|EnsemblGenome=HelroG163056|UniProtKB=T1ETM0 T1ETM0 20199920 PTHR11875:SF7 TESTIS-SPECIFIC Y-ENCODED PROTEIN AT14585P-RELATED protein binding#GO:0005515;protein-containing complex binding#GO:0044877;histone binding#GO:0042393;binding#GO:0005488;chromatin binding#GO:0003682 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;nucleosome organization#GO:0034728;nucleosome assembly#GO:0006334;protein-containing complex organization#GO:0043933;protein-containing complex assembly#GO:0065003;chromatin organization#GO:0006325;cellular component organization#GO:0016043;protein-DNA complex assembly#GO:0065004;chromatin remodeling#GO:0006338;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG185780|UniProtKB=T1FNA2 T1FNA2 20210299 PTHR21136:SF179 SNARE PROTEINS VESICLE ASSOCIATED MEMBRANE PROTEIN 7-RELATED molecular adaptor activity#GO:0060090;protein binding#GO:0005515;SNAP receptor activity#GO:0005484;binding#GO:0005488;SNARE binding#GO:0000149;protein-macromolecule adaptor activity#GO:0030674 vesicle fusion#GO:0006906;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;membrane fusion#GO:0061025;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;organelle organization#GO:0006996;vesicle organization#GO:0016050;export from cell#GO:0140352;organelle fusion#GO:0048284;secretion by cell#GO:0032940 SNARE complex#GO:0031201;cytoplasm#GO:0005737;membrane protein complex#GO:0098796;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034 HELRO|EnsemblGenome=HelroG173535|UniProtKB=T1F6Y5 T1F6Y5 20204584 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG192515|UniProtKB=T1FU16 T1FU16 20212312 PTHR22168:SF3 TMEM26 PROTEIN TRANSMEMBRANE PROTEIN 26 HELRO|EnsemblGenome=HelroG193014|UniProtKB=T1FUI7 T1FUI7 20212483 PTHR11848:SF308 TGF-BETA FAMILY BMP-LIKE PROTEIN UNC-129 molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;binding#GO:0005488;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;protein binding#GO:0005515;signaling receptor binding#GO:0005102 extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HELRO|EnsemblGenome=HelroG177287|UniProtKB=T1FBG5 T1FBG5 20206164 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178470|UniProtKB=T1FD78 T1FD78 20206777 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG81819|UniProtKB=T1G4J1 T1G4J1 20215989 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG194849|UniProtKB=T1FWH4 T1FWH4 20213169 PTHR13491:SF0 ZCCHC10 PROTEIN ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10 HELRO|EnsemblGenome=HelroG67852|UniProtKB=T1FZ62 T1FZ62 20214110 PTHR24353:SF153 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;cytosol#GO:0005829;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Enkephalin release#P05913>PKA#P05972;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Endothelin signaling pathway#P00019>PKA#P00570;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059 HELRO|EnsemblGenome=HelroG69402|UniProtKB=T1FZU8 T1FZU8 20214346 PTHR11158:SF17 MSF1/PX19 RELATED PROTEIN SLOWMO phospholipid transporter activity#GO:0005548;lipid transfer activity#GO:0120013;transporter activity#GO:0005215;lipid transporter activity#GO:0005319 localization#GO:0051179;organic substance transport#GO:0071702;organophosphate ester transport#GO:0015748;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;lipid localization#GO:0010876;phospholipid transport#GO:0015914;lipid transport#GO:0006869 envelope#GO:0031975;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;mitochondrial envelope#GO:0005740;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;mitochondrial intermembrane space#GO:0005758;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG170789|UniProtKB=T1F3F3 T1F3F3 20203352 PTHR23107:SF33 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN TRANSMEMBRANE PROTEIN gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG100238|UniProtKB=T1ECZ1 T1ECZ1 20194443 PTHR11588:SF7 TUBULIN TUBULIN GAMMA CHAIN carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;structural molecule activity#GO:0005198;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;structural constituent of cytoskeleton#GO:0005200 cellular component biogenesis#GO:0044085;mitotic spindle organization#GO:0007052;nuclear division#GO:0000280;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;protein-containing complex assembly#GO:0065003;microtubule cytoskeleton organization involved in mitosis#GO:1902850;microtubule polymerization or depolymerization#GO:0031109;mitotic cell cycle process#GO:1903047;chromosome segregation#GO:0007059;mitotic cell cycle#GO:0000278;microtubule polymerization#GO:0046785;meiotic cell cycle process#GO:1903046;supramolecular fiber organization#GO:0097435;reproductive process#GO:0022414;cytoskeleton organization#GO:0007010;mitotic nuclear division#GO:0140014;mitotic sister chromatid segregation#GO:0000070;spindle organization#GO:0007051;cellular component assembly#GO:0022607;nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;meiotic cell cycle#GO:0051321;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;reproduction#GO:0000003;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;chromosome organization#GO:0051276;organelle organization#GO:0006996;sexual reproduction#GO:0019953;protein polymerization#GO:0051258;cell cycle#GO:0007049;organelle fission#GO:0048285;microtubule nucleation#GO:0007020 supramolecular complex#GO:0099080;microtubule organizing center#GO:0005815;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;supramolecular fiber#GO:0099512;supramolecular polymer#GO:0099081;cellular anatomical entity#GO:0110165;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;centrosome#GO:0005813;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;spindle#GO:0005819;microtubule#GO:0005874 tubulin#PC00228;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG186114|UniProtKB=T1FNN9 T1FNN9 20210436 PTHR23382:SF3 MALATE DEHYDROGENASE MALATE DEHYDROGENASE, CYTOPLASMIC oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 cellular aromatic compound metabolic process#GO:0006725;dicarboxylic acid metabolic process#GO:0043648;pyridine nucleotide metabolic process#GO:0019362;nucleobase-containing compound metabolic process#GO:0006139;energy derivation by oxidation of organic compounds#GO:0015980;phosphorus metabolic process#GO:0006793;tricarboxylic acid cycle#GO:0006099;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;oxoacid metabolic process#GO:0043436;generation of precursor metabolites and energy#GO:0006091;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;nicotinamide nucleotide metabolic process#GO:0046496;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;carboxylic acid metabolic process#GO:0019752;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 dehydrogenase#PC00092;oxidoreductase#PC00176 TCA cycle#P00051>Malate Dehydrogenase#P01270 HELRO|EnsemblGenome=HelroG144824|UniProtKB=T1EJG6 T1EJG6 20196716 PTHR23138:SF94 RAN BINDING PROTEIN RAN BINDING PROTEIN 1 nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 envelope#GO:0031975;cytoplasm#GO:0005737;nuclear pore#GO:0005643;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG130656|UniProtKB=T1EHU4 T1EHU4 20196144 PTHR11814:SF55 SULFATE TRANSPORTER SODIUM-INDEPENDENT SULFATE ANION TRANSPORTER cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG189210|UniProtKB=T1FQS8 T1FQS8 20211175 PTHR46830:SF2 TRANSFERASE, PUTATIVE-RELATED ALPHA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG145141|UniProtKB=T1EJI8 T1EJI8 20196738 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG194547|UniProtKB=T1FW66 T1FW66 20213062 PTHR46539:SF23 E3 UBIQUITIN-PROTEIN LIGASE ATL42 RING-TYPE DOMAIN-CONTAINING PROTEIN ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191354|UniProtKB=T1FSX0 T1FSX0 20211917 PTHR12429:SF6 NEURALIZED PROTEIN NEURALIZED transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191019|UniProtKB=T1FSI2 T1FSI2 20211779 PTHR45696:SF10 60S ACIDIC RIBOSOMAL PROTEIN P1 LARGE RIBOSOMAL SUBUNIT PROTEIN P1 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG167913|UniProtKB=T1EZY2 T1EZY2 20202132 PTHR24243:SF230 G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG184494|UniProtKB=T1FLB5 T1FLB5 20209614 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164895|UniProtKB=T1EVX7 T1EVX7 20200727 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG167533|UniProtKB=T1EZG7 T1EZG7 20201967 PTHR31802:SF40 32 KDA HEAT SHOCK PROTEIN-RELATED ECM25P intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG71911|UniProtKB=T1G0T0 T1G0T0 20214678 PTHR24369:SF210 ANTIGEN BSP, PUTATIVE-RELATED CHAOPTIN-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG83262|UniProtKB=T1G529 T1G529 20216177 PTHR11062:SF73 EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED EXOSTOSIN-LIKE 3 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG106158|UniProtKB=T1EE05 T1EE05 20194807 PTHR11705:SF91 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B FI01817P-RELATED metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metallocarboxypeptidase activity#GO:0004181;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;carboxypeptidase activity#GO:0004180 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG166443|UniProtKB=T1EY51 T1EY51 20201501 PTHR12984:SF16 SCY1-RELATED S/T PROTEIN KINASE-LIKE BLACK MATCH, ISOFORM H non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG192840|UniProtKB=T1FUC6 T1FUC6 20212422 PTHR13808:SF1 CBP/P300-RELATED HISTONE ACETYLTRANSFERASE histone modifying activity#GO:0140993;nucleic acid binding#GO:0003676;acyltransferase activity#GO:0016746;peptide N-acetyltransferase activity#GO:0034212;binding#GO:0005488;catalytic activity#GO:0003824;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;N-acyltransferase activity#GO:0016410;histone acetyltransferase activity#GO:0004402;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;molecular adaptor activity#GO:0060090;N-acetyltransferase activity#GO:0008080;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;chromatin DNA binding#GO:0031490;transferase activity#GO:0016740;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;protein-containing complex binding#GO:0044877;catalytic activity, acting on a protein#GO:0140096 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of RNA metabolic process#GO:0051254;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;chromatin#GO:0000785;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;chromosome#GO:0005694 histone modifying enzyme#PC00261 DPP signaling pathway#P06213>NEJ#P06284;TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282;SCW signaling pathway#P06216>NEJ#P06328;GBB signaling pathway#P06214>NEJ#P06295;BMP/activin signaling pathway-drosophila#P06211>NEJ#P06246;p53 pathway#P00059>CBP#P04623;Wnt signaling pathway#P00057>CBP#P01448;Transcription regulation by bZIP transcription factor#P00055>CBP/P300#P01387;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CREB#P00713;DPP-SCW signaling pathway#P06212>NEJ#P06260;Huntington disease#P00029>CBP#P00777 HELRO|EnsemblGenome=HelroG81424|UniProtKB=T1G4E2 T1G4E2 20215940 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG187209|UniProtKB=T1FP77 T1FP77 20210624 PTHR11937:SF37 ACTIN ACTIN-RELATED PROTEIN 2 cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;Arp2/3 complex-mediated actin nucleation#GO:0034314;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;Arp2/3 protein complex#GO:0005885;cell cortex#GO:0005938;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 actin and actin related protein#PC00039;cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Alzheimer disease-presenilin pathway#P00004>actin#P00114;Huntington disease#P00029>Actin#P00807;Cadherin signaling pathway#P00012>F-actin#P00470 HELRO|EnsemblGenome=HelroG174768|UniProtKB=T1F8G0 T1F8G0 20205109 PTHR12582:SF47 NETRIN RECEPTOR UNC5 NETRIN RECEPTOR UNC-5 transmembrane signal receptor#PC00197 Axon guidance mediated by netrin#P00009>UNC-5#P00356 HELRO|EnsemblGenome=HelroG178296|UniProtKB=T1FD20 T1FD20 20206719 PTHR21437:SF1 WIDE AWAKE WIDE AWAKE HELRO|EnsemblGenome=HelroG104138|UniProtKB=T1EDJ9 T1EDJ9 20194651 PTHR11675:SF43 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 1 transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG111800|UniProtKB=T1EFE8 T1EFE8 20195300 PTHR18034:SF4 CELL CYCLE CONTROL PROTEIN CWF22-RELATED NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;ribosome biogenesis#GO:0042254;cellular process#GO:0009987;ribosomal small subunit biogenesis#GO:0042274;ribonucleoprotein complex biogenesis#GO:0022613 membrane-enclosed lumen#GO:0031974;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG191416|UniProtKB=T1FSY8 T1FSY8 20211935 PTHR24093:SF369 CATION TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE calcium ion transmembrane transporter activity#GO:0015085;inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;P-type ion transporter activity#GO:0015662;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075 intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG113976|UniProtKB=T1EFX8 T1EFX8 20195480 PTHR11742:SF55 MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 carbohydrate derivative metabolic process#GO:1901135;macromolecule modification#GO:0043412;protein catabolic process#GO:0030163;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;macromolecule catabolic process#GO:0009057;response to endoplasmic reticulum stress#GO:0034976;response to oxygen-containing compound#GO:1901700;macromolecule metabolic process#GO:0043170;carbohydrate derivative catabolic process#GO:1901136;organonitrogen compound metabolic process#GO:1901564;ERAD pathway#GO:0036503;response to organonitrogen compound#GO:0010243;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;cellular response to stress#GO:0033554 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG64272|UniProtKB=T1FXS1 T1FXS1 20213619 PTHR43716:SF1 D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG63750|UniProtKB=T1FXJ8 T1FXJ8 20213546 PTHR10736:SF65 BESTROPHIN BESTROPHIN 1, ISOFORM C-RELATED inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;channel activity#GO:0015267 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG192732|UniProtKB=T1FU86 T1FU86 20212382 PTHR12385:SF12 CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44) CHOLINE TRANSPORTER-LIKE PROTEIN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG162406|UniProtKB=T1ESM1 T1ESM1 20199571 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG62554|UniProtKB=T1FX23 T1FX23 20213371 PTHR13697:SF4 PHOSPHOFRUCTOKINASE ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;phosphotransferase activity, alcohol group as acceptor#GO:0016773;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;carbohydrate kinase activity#GO:0019200;carbohydrate binding#GO:0030246;kinase activity#GO:0016301;cation binding#GO:0043169;transferase activity#GO:0016740;organic cyclic compound binding#GO:0097159;identical protein binding#GO:0042802;nucleoside phosphate binding#GO:1901265;protein binding#GO:0005515;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;ATP binding#GO:0005524;monosaccharide binding#GO:0048029 ribonucleoside triphosphate metabolic process#GO:0009199;nucleoside triphosphate metabolic process#GO:0009141;heterocycle catabolic process#GO:0046700;ribonucleotide catabolic process#GO:0009261;pyridine nucleotide metabolic process#GO:0019362;nucleobase-containing compound metabolic process#GO:0006139;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;purine ribonucleotide catabolic process#GO:0009154;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;oxoacid metabolic process#GO:0043436;nucleoside phosphate catabolic process#GO:1901292;carbohydrate derivative catabolic process#GO:1901136;purine ribonucleoside triphosphate metabolic process#GO:0009205;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;nucleotide catabolic process#GO:0009166;cellular nitrogen compound metabolic process#GO:0034641;nicotinamide nucleotide metabolic process#GO:0046496;nucleoside diphosphate catabolic process#GO:0009134;organic acid metabolic process#GO:0006082;ribonucleotide metabolic process#GO:0009259;monocarboxylic acid metabolic process#GO:0032787;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;organophosphate catabolic process#GO:0046434;small molecule catabolic process#GO:0044282;glycolytic process#GO:0006096;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;nucleotide metabolic process#GO:0009117;small molecule metabolic process#GO:0044281;cellular aromatic compound metabolic process#GO:0006725;monosaccharide metabolic process#GO:0005996;carbohydrate derivative metabolic process#GO:1901135;organonitrogen compound catabolic process#GO:1901565;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;purine-containing compound catabolic process#GO:0072523;cellular nitrogen compound catabolic process#GO:0044270;purine nucleotide catabolic process#GO:0006195;organic cyclic compound metabolic process#GO:1901360;carbohydrate catabolic process#GO:0016052;nucleoside diphosphate metabolic process#GO:0009132;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carbohydrate metabolic process#GO:0005975;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;heterocycle metabolic process#GO:0046483;organonitrogen compound metabolic process#GO:1901564;cellular process#GO:0009987;glucose metabolic process#GO:0006006;aromatic compound catabolic process#GO:0019439;organic cyclic compound catabolic process#GO:1901361;purine nucleoside triphosphate metabolic process#GO:0009144;hexose metabolic process#GO:0019318;carboxylic acid metabolic process#GO:0019752;nucleobase-containing small molecule metabolic process#GO:0055086 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695 carbohydrate kinase#PC00065 Glycolysis#P00024>Phosphofructokinase-1#P00672 HELRO|EnsemblGenome=HelroG112898|UniProtKB=T1EFN1 T1EFN1 20195383 PTHR47958:SF104 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE WM6 catalytic activity, acting on RNA#GO:0140098;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640;mRNA binding#GO:0003729 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG166833|UniProtKB=T1EYL5 T1EYL5 20201665 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG64618|UniProtKB=T1FXX2 T1FXX2 20213670 PTHR10027:SF33 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic ion-gated channel activity#GO:0022839;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium-activated cation channel activity#GO:0005227;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG170339|UniProtKB=T1F2X8 T1F2X8 20203177 PTHR24410:SF41 HL07962P-RELATED HL07962P defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG142669|UniProtKB=T1EJ68 T1EJ68 20196618 PTHR24343:SF348 SERINE/THREONINE KINASE AT25266P transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG169050|UniProtKB=T1F1B6 T1F1B6 20202616 PTHR47055:SF3 DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 HELRO|EnsemblGenome=HelroG189343|UniProtKB=T1FQZ4 T1FQZ4 20211241 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG180906|UniProtKB=T1FGE4 T1FGE4 20207893 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179895|UniProtKB=T1FF85 T1FF85 20207484 PTHR31004:SF1 TRANSMEMBRANE PROTEIN 79 TRANSMEMBRANE PROTEIN 79 localization#GO:0051179;regulated exocytosis#GO:0045055;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;export from cell#GO:0140352;secretion by cell#GO:0032940 bounding membrane of organelle#GO:0098588;trans-Golgi network#GO:0005802;lytic vacuole membrane#GO:0098852;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;vacuolar membrane#GO:0005774;vacuole#GO:0005773;trans-Golgi network membrane#GO:0032588;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;lytic vacuole#GO:0000323;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;lysosomal membrane#GO:0005765;lysosome#GO:0005764;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791 HELRO|EnsemblGenome=HelroG174206|UniProtKB=T1F7S5 T1F7S5 20204874 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG169381|UniProtKB=T1F1V6 T1F1V6 20202806 PTHR34153:SF2 SI:CH211-262H13.3-RELATED-RELATED SI:CH211-262H13.3-RELATED HELRO|EnsemblGenome=HelroG92598|UniProtKB=T1G8I7 T1G8I7 20217384 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG135178|UniProtKB=T1EI70 T1EI70 20196270 PTHR20974:SF0 UPF0585 PROTEIN CG18661 UPF0585 PROTEIN CG18661 HELRO|EnsemblGenome=HelroG168092|UniProtKB=T1F057 T1F057 20202207 PTHR11537:SF113 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;delayed rectifier potassium channel activity#GO:0005251;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG132173|UniProtKB=T1EHX4 T1EHX4 20196174 PTHR10026:SF13 CYCLIN LD24704P protein kinase regulator activity#GO:0019887;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 kinase activator#PC00138 HELRO|EnsemblGenome=HelroG185115|UniProtKB=T1FME8 T1FME8 20209997 PTHR19278:SF9 OROTATE PHOSPHORIBOSYLTRANSFERASE URIDINE 5'-MONOPHOSPHATE SYNTHASE transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;pentosyltransferase activity#GO:0016763;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;pyrimidine nucleotide metabolic process#GO:0006220;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;pyrimidine-containing compound metabolic process#GO:0072527;biosynthetic process#GO:0009058;nucleobase metabolic process#GO:0009112;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;pyrimidine nucleobase metabolic process#GO:0006206;nucleoside monophosphate metabolic process#GO:0009123;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribonucleoside monophosphate metabolic process#GO:0009161;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 transferase#PC00220;metabolite interconversion enzyme#PC00262 De novo pyrimidine ribonucleotides biosythesis#P02740>Orotate phosphoribosyltransferase#P02922 HELRO|EnsemblGenome=HelroG90393|UniProtKB=T1G7Q6 T1G7Q6 20217103 PTHR45646:SF11 SERINE/THREONINE-PROTEIN KINASE DOA-RELATED SERINE_THREONINE-PROTEIN KINASE DOA transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG160414|UniProtKB=T1EQ80 T1EQ80 20198730 PTHR23248:SF9 PHOSPHOLIPID SCRAMBLASE-RELATED PHOSPHOLIPID SCRAMBLASE phospholipid transporter activity#GO:0005548;transporter activity#GO:0005215;lipid transporter activity#GO:0005319 organophosphate ester transport#GO:0015748;macromolecule localization#GO:0033036;membrane organization#GO:0061024;plasma membrane organization#GO:0007009;transport#GO:0006810;plasma membrane phospholipid scrambling#GO:0017121;endomembrane system organization#GO:0010256;cellular component organization#GO:0016043;regulation of membrane lipid distribution#GO:0097035;phospholipid transport#GO:0015914;cellular process#GO:0009987;lipid transport#GO:0006869;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;biological regulation#GO:0065007;lipid translocation#GO:0034204;lipid localization#GO:0010876;phospholipid translocation#GO:0045332 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG167650|UniProtKB=T1EZM3 T1EZM3 20202023 PTHR24392:SF49 ZINC FINGER PROTEIN PROTEIN HUNCHBACK C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG188738|UniProtKB=T1FQB4 T1FQB4 20211011 PTHR13161:SF4 SPLICING FACTOR SUPPRESSOR OF WHITE APRICOT CLK4-ASSOCIATING SERINE_ARGININE RICH PROTEIN RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG63471|UniProtKB=T1FXG3 T1FXG3 20213511 PTHR45689:SF5 I[[H]] CHANNEL, ISOFORM E I[[H]] CHANNEL, ISOFORM E monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;sodium ion transport#GO:0006814;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;regulation of membrane depolarization#GO:0003254;sodium ion transmembrane transport#GO:0035725;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG136179|UniProtKB=T1EIC4 T1EIC4 20196324 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG75879|UniProtKB=T1G2C1 T1G2C1 20215219 PTHR24637:SF388 COLLAGEN NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175511|UniProtKB=T1F9C4 T1F9C4 20205423 PTHR13282:SF6 PROTEIN FAM32A PROTEIN FAM32A intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG136060|UniProtKB=T1EIB7 T1EIB7 20196317 PTHR11106:SF27 GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED MACRO DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG81862|UniProtKB=T1G4J7 T1G4J7 20215995 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG156069|UniProtKB=T1ELR3 T1ELR3 20197513 PTHR11431:SF75 FERRITIN FERRITIN cation binding#GO:0043169;ferrous iron binding#GO:0008198;small molecule binding#GO:0036094;binding#GO:0005488;iron ion binding#GO:0005506;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;ion binding#GO:0043167 localization#GO:0051179;inorganic ion homeostasis#GO:0098771;cellular localization#GO:0051641;intracellular iron ion homeostasis#GO:0006879;maintenance of location#GO:0051235;maintenance of location in cell#GO:0051651;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;chemical homeostasis#GO:0048878;cellular process#GO:0009987;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 storage protein#PC00210 HELRO|EnsemblGenome=HelroG65946|UniProtKB=T1FYE8 T1FYE8 20213846 PTHR10736:SF65 BESTROPHIN BESTROPHIN 1, ISOFORM C-RELATED inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;channel activity#GO:0015267 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG172375|UniProtKB=T1F585 T1F585 20203984 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177933|UniProtKB=T1FCH4 T1FCH4 20206523 PTHR13128:SF12 VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36 VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36 protein binding#GO:0005515;ubiquitin-like protein binding#GO:0032182;binding#GO:0005488;ubiquitin binding#GO:0043130 endosomal transport#GO:0016197;cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;protein catabolic process#GO:0030163;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;nitrogen compound transport#GO:0071705;organonitrogen compound catabolic process#GO:1901565;late endosome to vacuole transport#GO:0045324;protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043328;establishment of protein localization#GO:0045184;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;modification-dependent macromolecule catabolic process#GO:0043632;organic substance transport#GO:0071702;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein localization to organelle#GO:0033365;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;establishment of protein localization to vacuole#GO:0072666;modification-dependent protein catabolic process#GO:0019941;vacuolar transport#GO:0007034;macromolecule metabolic process#GO:0043170;protein localization to vacuole#GO:0072665;organonitrogen compound metabolic process#GO:1901564;establishment of protein localization to organelle#GO:0072594;vesicle-mediated transport#GO:0016192;multivesicular body sorting pathway#GO:0071985;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein localization#GO:0008104;ubiquitin-dependent protein catabolic process#GO:0006511;localization#GO:0051179;cellular macromolecule localization#GO:0070727;protein transport#GO:0015031;endosome transport via multivesicular body sorting pathway#GO:0032509;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;late endosome membrane#GO:0031902;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endosome membrane#GO:0010008;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG180434|UniProtKB=T1FFX1 T1FFX1 20207720 PTHR10744:SF9 40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER 40S RIBOSOMAL PROTEIN S11-RELATED structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;small ribosomal subunit#GO:0015935;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG89579|UniProtKB=T1G7E7 T1G7E7 20216994 PTHR31539:SF1 CENTROSOMAL PROTEIN OF 19K CEP19 CENTROSOMAL PROTEIN OF 19 KDA vesicle targeting, to, from or within Golgi#GO:0048199;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;cilium assembly#GO:0060271;organelle localization#GO:0051640;cell projection organization#GO:0030030;vesicle localization#GO:0051648;transport#GO:0006810;microtubule cytoskeleton organization#GO:0000226;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;vesicle targeting, trans-Golgi to periciliary membrane compartment#GO:0097712;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;vesicle targeting#GO:0006903;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;localization#GO:0051179;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;organelle organization#GO:0006996;establishment of vesicle localization#GO:0051650;establishment of localization in cell#GO:0051649;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection assembly#GO:0120031;establishment of organelle localization#GO:0051656 spindle pole#GO:0000922;microtubule organizing center#GO:0005815;cellular anatomical entity#GO:0110165;centriole#GO:0005814;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929;spindle#GO:0005819 HELRO|EnsemblGenome=HelroG145076|UniProtKB=T1EJI5 T1EJI5 20196735 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED single-stranded RNA binding#GO:0003727;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;poly(A) binding#GO:0008143;binding#GO:0005488;organic cyclic compound binding#GO:0097159 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG194877|UniProtKB=T1FWI6 T1FWI6 20213181 PTHR45679:SF6 ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2 ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2 hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 carbohydrate derivative metabolic process#GO:1901135;macromolecule modification#GO:0043412;protein catabolic process#GO:0030163;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;macromolecule catabolic process#GO:0009057;response to endoplasmic reticulum stress#GO:0034976;response to oxygen-containing compound#GO:1901700;macromolecule metabolic process#GO:0043170;carbohydrate derivative catabolic process#GO:1901136;organonitrogen compound metabolic process#GO:1901564;ERAD pathway#GO:0036503;response to organonitrogen compound#GO:0010243;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;cellular response to stress#GO:0033554 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG165596|UniProtKB=T1EX21 T1EX21 20201121 PTHR14312:SF6 CREB/ATF BZIP TRANSCRIPTION FACTOR SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG70057|UniProtKB=T1G019 T1G019 20214417 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177639|UniProtKB=T1FBZ6 T1FBZ6 20206345 PTHR48043:SF145 EG:EG0003.4 PROTEIN-RELATED FI06409P-RELATED HELRO|EnsemblGenome=HelroG109499|UniProtKB=T1EEU3 T1EEU3 20195095 PTHR11521:SF1 TROPONIN T TROPONIN T, SKELETAL MUSCLE cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;binding#GO:0005488 cellular component biogenesis#GO:0044085;muscle cell differentiation#GO:0042692;system process#GO:0003008;developmental process#GO:0032502;myofibril assembly#GO:0030239;cellular anatomical entity morphogenesis#GO:0032989;muscle structure development#GO:0061061;striated muscle cell differentiation#GO:0051146;cell differentiation#GO:0030154;actin filament-based process#GO:0030029;anatomical structure morphogenesis#GO:0009653;supramolecular fiber organization#GO:0097435;striated muscle cell development#GO:0055002;cytoskeleton organization#GO:0007010;non-membrane-bounded organelle assembly#GO:0140694;sarcomere organization#GO:0045214;cellular developmental process#GO:0048869;cellular component assembly#GO:0022607;cellular component assembly involved in morphogenesis#GO:0010927;cellular component organization#GO:0016043;actomyosin structure organization#GO:0031032;cellular process#GO:0009987;anatomical structure formation involved in morphogenesis#GO:0048646;organelle assembly#GO:0070925;cell development#GO:0048468;muscle cell development#GO:0055001;cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;anatomical structure development#GO:0048856;multicellular organismal process#GO:0032501;actin cytoskeleton organization#GO:0030036;muscle system process#GO:0003012;muscle contraction#GO:0006936 supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;organelle#GO:0043226;contractile fiber#GO:0043292;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;sarcomere#GO:0030017;cytoskeleton#GO:0005856;myofibril#GO:0030016 cytoskeletal protein#PC00085;actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG193983|UniProtKB=T1FVJ3 T1FVJ3 20212839 PTHR23168:SF0 MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1 MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 negative regulation of sister chromatid segregation#GO:0033046;cellular localization#GO:0051641;regulation of mitotic nuclear division#GO:0007088;organelle localization#GO:0051640;regulation of chromosome segregation#GO:0051983;mitotic cell cycle checkpoint signaling#GO:0007093;nuclear division#GO:0000280;negative regulation of chromosome organization#GO:2001251;attachment of mitotic spindle microtubules to kinetochore#GO:0051315;negative regulation of mitotic nuclear division#GO:0045839;regulation of cellular component organization#GO:0051128;negative regulation of nuclear division#GO:0051784;negative regulation of mitotic sister chromatid segregation#GO:0033048;chromosome segregation#GO:0007059;regulation of biological process#GO:0050789;cell cycle checkpoint signaling#GO:0000075;mitotic cell cycle#GO:0000278;establishment of localization#GO:0051234;regulation of mitotic sister chromatid segregation#GO:0033047;attachment of spindle microtubules to kinetochore#GO:0008608;intracellular signal transduction#GO:0035556;negative regulation of cellular component organization#GO:0051129;establishment of organelle localization#GO:0051656;nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;negative regulation of cell cycle#GO:0045786;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of organelle organization#GO:0033043;mitotic spindle assembly checkpoint signaling#GO:0007094;negative regulation of chromosome segregation#GO:0051985;regulation of cell cycle phase transition#GO:1901987;cellular component organization#GO:0016043;cell communication#GO:0007154;regulation of mitotic metaphase/anaphase transition#GO:0030071;regulation of cell cycle process#GO:0010564;cellular component organization or biogenesis#GO:0071840;mitotic metaphase chromosome alignment#GO:0007080;chromosome organization#GO:0051276;regulation of cellular process#GO:0050794;chromosome localization#GO:0050000;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100;negative regulation of mitotic sister chromatid separation#GO:2000816;signal transduction#GO:0007165;negative regulation of biological process#GO:0048519;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;regulation of chromosome separation#GO:1905818;cell cycle process#GO:0022402;negative regulation of cell cycle process#GO:0010948;mitotic cell cycle process#GO:1903047;negative regulation of mitotic cell cycle phase transition#GO:1901991;negative regulation of organelle organization#GO:0010639;mitotic nuclear division#GO:0140014;mitotic sister chromatid segregation#GO:0000070;signaling#GO:0023052;negative regulation of cellular process#GO:0048523;regulation of chromosome organization#GO:0033044;cellular response to stimulus#GO:0051716;regulation of mitotic sister chromatid separation#GO:0010965;regulation of nuclear division#GO:0051783;establishment of chromosome localization#GO:0051303;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of mitotic cell cycle#GO:0045930;cellular process#GO:0009987;localization#GO:0051179;response to stimulus#GO:0050896;negative regulation of chromosome separation#GO:1905819;organelle organization#GO:0006996;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;establishment of localization in cell#GO:0051649;organelle fission#GO:0048285;regulation of sister chromatid segregation#GO:0033045;regulation of mitotic cell cycle#GO:0007346;metaphase chromosome alignment#GO:0051310 envelope#GO:0031975;supramolecular complex#GO:0099080;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;kinetochore#GO:0000776;nuclear envelope#GO:0005635;condensed chromosome, centromeric region#GO:0000779;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;endomembrane system#GO:0012505;mitotic spindle#GO:0072686;chromosome#GO:0005694;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;chromosomal region#GO:0098687;cytoskeleton#GO:0005856;spindle#GO:0005819 HELRO|EnsemblGenome=HelroG156792|UniProtKB=T1EM12 T1EM12 20197612 PTHR11829:SF377 FORKHEAD BOX PROTEIN FORK HEAD DOMAIN-CONTAINING PROTEIN FD4-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;anatomical structure morphogenesis#GO:0009653;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG192994|UniProtKB=T1FUH7 T1FUH7 20212473 PTHR12196:SF2 DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN DIPHTHINE--AMMONIA LIGASE ligase activity#GO:0016874;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;primary metabolic process#GO:0044238 HELRO|EnsemblGenome=HelroG171810|UniProtKB=T1F4Q1 T1F4Q1 20203800 PTHR44592:SF3 NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN SECRETED PROTEIN HELRO|EnsemblGenome=HelroG130200|UniProtKB=T1EHT3 T1EHT3 20196133 PTHR10117:SF54 TRANSIENT RECEPTOR POTENTIAL CHANNEL TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;small molecule binding#GO:0036094;binding#GO:0005488;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;anion binding#GO:0043168;ion binding#GO:0043167;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;alcohol binding#GO:0043178 inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;regulation of cytosolic calcium ion concentration#GO:0051480;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;calcium ion transport#GO:0006816;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 Alzheimer disease-presenilin pathway#P00004>Capacitative calcium channels#P00124 HELRO|EnsemblGenome=HelroG74907|UniProtKB=T1G1X7 T1G1X7 20215075 PTHR11849:SF304 ETS DNA-BINDING PROTEIN D-ETS-3 transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG159270|UniProtKB=T1ENT2 T1ENT2 20198232 PTHR10504:SF131 BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED BPI2 DOMAIN-CONTAINING PROTEIN defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG186223|UniProtKB=T1FNU1 T1FNU1 20210488 PTHR43153:SF1 ELECTRON TRANSFER FLAVOPROTEIN ALPHA ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;flavin adenine dinucleotide binding#GO:0050660;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167 oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;lipid oxidation#GO:0034440;cellular metabolic process#GO:0044237;lipid catabolic process#GO:0016042;lipid modification#GO:0030258;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;fatty acid catabolic process#GO:0009062;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;fatty acid metabolic process#GO:0006631;small molecule catabolic process#GO:0044282;fatty acid beta-oxidation#GO:0006635;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;carboxylic acid metabolic process#GO:0019752;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG182503|UniProtKB=T1FIA2 T1FIA2 20208551 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186209|UniProtKB=T1FNT6 T1FNT6 20210483 PTHR11911:SF111 INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 ribonucleoside triphosphate metabolic process#GO:0009199;cellular aromatic compound metabolic process#GO:0006725;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;nucleotide biosynthetic process#GO:0009165;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;purine nucleoside triphosphate biosynthetic process#GO:0009145;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;purine ribonucleoside triphosphate metabolic process#GO:0009205;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;ribonucleoside triphosphate biosynthetic process#GO:0009201;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;purine nucleoside triphosphate metabolic process#GO:0009144;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 dehydrogenase#PC00092;oxidoreductase#PC00176 De novo purine biosynthesis#P02738>IMP dehydrogenase#P02895 HELRO|EnsemblGenome=HelroG65441|UniProtKB=T1FY78 T1FY78 20213776 PTHR19134:SF562 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE PROTEIN-TYROSINE-PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG163175|UniProtKB=T1ETR3 T1ETR3 20199963 PTHR46464:SF2 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN ANKYRIN AND ARMADILLO REPEAT-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG160196|UniProtKB=T1EPY3 T1EPY3 20198633 PTHR24230:SF163 G-PROTEIN COUPLED RECEPTOR CORAZONIN RECEPTOR, ISOFORM B signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;neuropeptide signaling pathway#GO:0007218;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG172081|UniProtKB=T1F504 T1F504 20203903 PTHR24270:SF61 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 apolipoprotein#PC00052 HELRO|EnsemblGenome=HelroG121545|UniProtKB=T1EGS3 T1EGS3 20195773 PTHR18945:SF856 NEUROTRANSMITTER GATED ION CHANNEL GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA signaling receptor activity#GO:0038023;inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;molecular transducer activity#GO:0060089;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;transmembrane signaling receptor activity#GO:0004888 localization#GO:0051179;inorganic anion transmembrane transport#GO:0098661;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic anion transport#GO:0006820;chloride transport#GO:0006821;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;inorganic anion transport#GO:0015698 receptor complex#GO:0043235;protein-containing complex#GO:0032991 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG93044|UniProtKB=T1G8R7 T1G8R7 20217464 PTHR34410:SF2 INTRON-ENCODED HOMING ENDONUCLEASE, PUTATIVE-RELATED RRNA INTRON-ENCODED HOMING ENDONUCLEASE HELRO|EnsemblGenome=HelroG113992|UniProtKB=T1EFX9 T1EFX9 20195481 PTHR24006:SF937 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG102116|UniProtKB=T1ED81 T1ED81 20194533 PTHR45727:SF2 NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1 NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1 lipid binding#GO:0008289;binding#GO:0005488;organic cyclic compound binding#GO:0097159;steroid binding#GO:0005496;sterol binding#GO:0032934 localization#GO:0051179;organic hydroxy compound transport#GO:0015850;organic substance transport#GO:0071702;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;sterol transport#GO:0015918;transport#GO:0006810;lipid localization#GO:0010876;lipid transport#GO:0006869 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG189778|UniProtKB=T1FRD3 T1FRD3 20211380 PTHR19965:SF22 RNA AND EXPORT FACTOR BINDING PROTEIN CHROMATIN TARGET OF PRMT1-LIKE 1 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;mRNA transport#GO:0051028;RNA localization#GO:0006403;localization#GO:0051179;organic substance transport#GO:0071702;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG75249|UniProtKB=T1G230 T1G230 20215128 PTHR45668:SF3 SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE RDGC protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG106532|UniProtKB=T1EE32 T1EE32 20194834 PTHR43691:SF11 URIDINE PHOSPHORYLASE FI09636P-RELATED cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 nucleotide kinase#PC00172 Salvage pyrimidine ribonucleotides#P02775>Uridine phosphorylase#P03152 HELRO|EnsemblGenome=HelroG80436|UniProtKB=T1G407 T1G407 20215805 PTHR11177:SF317 CHITINASE CHITINASE 12-RELATED glycosidase#PC00110;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG183003|UniProtKB=T1FJ29 T1FJ29 20208828 PTHR14815:SF2 DDB1- AND CUL4-ASSOCIATED FACTOR 17 DDB1- AND CUL4-ASSOCIATED FACTOR 17 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234;Cul4-RING E3 ubiquitin ligase complex#GO:0080008 HELRO|EnsemblGenome=HelroG180031|UniProtKB=T1FFD2 T1FFD2 20207531 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG112732|UniProtKB=T1EFL6 T1EFL6 20195368 PTHR12422:SF1 GH09096P GH09096P HELRO|EnsemblGenome=HelroG158888|UniProtKB=T1END7 T1END7 20198087 PTHR10129:SF48 TRANSCRIPTION FACTOR MAF MAF-S, ISOFORM B sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;basic leucine zipper transcription factor#PC00056 HELRO|EnsemblGenome=HelroG182328|UniProtKB=T1FI26 T1FI26 20208475 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175938|UniProtKB=T1F9X8 T1F9X8 20205627 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161921|UniProtKB=T1ES17 T1ES17 20199367 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168624|UniProtKB=T1F0T0 T1F0T0 20202430 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG82350|UniProtKB=T1G4R0 T1G4R0 20216058 PTHR42884:SF3 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED FURIN-LIKE PROTEASE 1, ISOFORMS 1_1-X_2 hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 bounding membrane of organelle#GO:0098588;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791;Golgi membrane#GO:0000139 serine protease#PC00203;protein modifying enzyme#PC00260 Activin beta signaling pathway#P06210>FUR1#P06238;Endothelin signaling pathway#P00019>furin#P00575;GBB signaling pathway#P06214>FUR1#P06298;SCW signaling pathway#P06216>FUR1#P06333;DPP-SCW signaling pathway#P06212>FUR1#P06263;DPP signaling pathway#P06213>FUR1#P06290;ALP23B signaling pathway#P06209>FUR1#P06227;Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105;BMP/activin signaling pathway-drosophila#P06211>Furin#P06244;Alzheimer disease-presenilin pathway#P00004>Furin#P00157;MYO signaling pathway#P06215>FUR1#P06318 HELRO|EnsemblGenome=HelroG193156|UniProtKB=T1FUP0 T1FUP0 20212536 PTHR11533:SF299 PROTEASE M1 ZINC METALLOPROTEASE AMINOPEPTIDASE metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;amide binding#GO:0033218;metal ion binding#GO:0046872;peptidase activity#GO:0008233;metalloaminopeptidase activity#GO:0070006;cation binding#GO:0043169;peptide binding#GO:0042277;hydrolase activity#GO:0016787;aminopeptidase activity#GO:0004177;exopeptidase activity#GO:0008238;ion binding#GO:0043167;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;peptide catabolic process#GO:0043171;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;membrane#GO:0016020;extracellular region#GO:0005576;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG172026|UniProtKB=T1F4Y5 T1F4Y5 20203884 PTHR13703:SF54 SMAD MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG cis-regulatory region sequence-specific DNA binding#GO:0000987;SMAD binding#GO:0046332;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;molecular function regulator activity#GO:0098772;binding#GO:0005488;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;protein binding#GO:0005515;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;molecular function inhibitor activity#GO:0140678 signal transduction#GO:0007165;regulation of nitrogen compound metabolic process#GO:0051171;response to growth factor#GO:0070848;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;cellular response to BMP stimulus#GO:0071773;cell differentiation#GO:0030154;response to endogenous stimulus#GO:0009719;anatomical structure morphogenesis#GO:0009653;regulation of biosynthetic process#GO:0009889;response to BMP#GO:0071772;regulation of macromolecule biosynthetic process#GO:0010556;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;regulation of gene expression#GO:0010468;signaling#GO:0023052;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;cellular response to endogenous stimulus#GO:0071495;regulation of DNA-templated transcription#GO:0006355;BMP signaling pathway#GO:0030509;cell communication#GO:0007154;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;cellular response to growth factor stimulus#GO:0071363;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;cell surface receptor signaling pathway#GO:0007166;anatomical structure development#GO:0048856;transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0007178;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 TGF-beta signaling pathway#P00052>RSmads#P01292 HELRO|EnsemblGenome=HelroG75193|UniProtKB=T1G225 T1G225 20215123 PTHR42985:SF40 SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER LD47995P-RELATED symporter activity#GO:0015293;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;monoatomic cation transport#GO:0006812;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG166124|UniProtKB=T1EXT6 T1EXT6 20201386 PTHR24418:SF162 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE ABL protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG95171|UniProtKB=T1G948 T1G948 20217595 PTHR12961:SF0 CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2 localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;Golgi organization#GO:0007030;establishment of localization#GO:0051234;intra-Golgi vesicle-mediated transport#GO:0006891;organelle organization#GO:0006996;transport#GO:0006810;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;vesicle tethering complex#GO:0099023;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;Golgi transport complex#GO:0017119;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG193294|UniProtKB=T1FUU5 T1FUU5 20212591 PTHR15346:SF0 DYNACTIN SUBUNIT DYNACTIN SUBUNIT 2 cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;mitotic spindle organization#GO:0007052;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;cell cycle#GO:0007049;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;spindle organization#GO:0007051;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;microtubule cytoskeleton#GO:0015630;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG189715|UniProtKB=T1FRA4 T1FRA4 20211351 PTHR16206:SF4 DEP DOMAIN-CONTAINING PROTEIN LET-99 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG192239|UniProtKB=T1FTR1 T1FTR1 20212208 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG89022|UniProtKB=T1G781 T1G781 20216928 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-LIKE 1 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;localization#GO:0051179;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 membrane protein complex#GO:0098796;synapse#GO:0045202;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron projection#GO:0043005;transmembrane transporter complex#GO:1902495;cell projection#GO:0042995;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HELRO|EnsemblGenome=HelroG159593|UniProtKB=T1EP78 T1EP78 20198378 PTHR13217:SF6 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052;Rho protein signal transduction#GO:0007266 HELRO|EnsemblGenome=HelroG184695|UniProtKB=T1FLS5 T1FLS5 20209774 PTHR46579:SF2 F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188557|UniProtKB=T1FQ43 T1FQ43 20210940 PTHR22948:SF76 TUDOR DOMAIN CONTAINING PROTEIN FI20010P1-RELATED scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG174935|UniProtKB=T1F8M7 T1F8M7 20205176 PTHR22198:SF1 FERM DOMAIN-CONTAINING PROTEIN FERM DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG65582|UniProtKB=T1FYA1 T1FYA1 20213799 PTHR13259:SF1 BLADDER CANCER 10 KD PROTEIN HOMOLOG BLADDER CANCER-ASSOCIATED PROTEIN HELRO|EnsemblGenome=HelroG169354|UniProtKB=T1F1T9 T1F1T9 20202789 PTHR31954:SF1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157 cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cilium#GO:0005929;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 structural protein#PC00211 HELRO|EnsemblGenome=HelroG83902|UniProtKB=T1G5B4 T1G5B4 20216261 PTHR12622:SF45 DELTEX-RELATED RING-TYPE E3 UBIQUITIN TRANSFERASE transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cell communication#GO:0007154;cellular process#GO:0009987;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;Notch signaling pathway#GO:0007219 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG166754|UniProtKB=T1EYG9 T1EYG9 20201619 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG112481|UniProtKB=T1EFK3 T1EFK3 20195355 PTHR11254:SF395 HECT DOMAIN UBIQUITIN-PROTEIN LIGASE E3 UBIQUITIN-PROTEIN LIGASE SMURF1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 negative regulation of biological process#GO:0048519;macromolecule modification#GO:0043412;regulation of signaling#GO:0023051;protein catabolic process#GO:0030163;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;regulation of biological process#GO:0050789;regulation of BMP signaling pathway#GO:0030510;modification-dependent macromolecule catabolic process#GO:0043632;negative regulation of BMP signaling pathway#GO:0030514;nitrogen compound metabolic process#GO:0006807;regulation of signal transduction#GO:0009966;proteolysis#GO:0006508;regulation of cellular response to growth factor stimulus#GO:0090287;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;negative regulation of cellular process#GO:0048523;proteolysis involved in protein catabolic process#GO:0051603;negative regulation of cell communication#GO:0010648;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;regulation of cell communication#GO:0010646;macromolecule catabolic process#GO:0009057;protein ubiquitination#GO:0016567;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation or removal#GO:0070647;negative regulation of response to stimulus#GO:0048585;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;negative regulation of signaling#GO:0023057;organonitrogen compound metabolic process#GO:1901564;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;regulation of response to stimulus#GO:0048583;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 SCW signaling pathway#P06216>LACK#P06321;Activin beta signaling pathway#P06210>LACK#P06230;DPP signaling pathway#P06213>LACK#P06278;TGF-beta signaling pathway#P00052>Smurfs#P01279;BMP/activin signaling pathway-drosophila#P06211>Smurf#P06243;ALP23B signaling pathway#P06209>LACK#P06219;DPP-SCW signaling pathway#P06212>LACK#P06269;GBB signaling pathway#P06214>LACK#P06303;MYO signaling pathway#P06215>LACK#P06309 HELRO|EnsemblGenome=HelroG112207|UniProtKB=T1EFH7 T1EFH7 20195329 PTHR13906:SF16 PORCUPINE LYSOPHOSPHOLIPID ACYLTRANSFERASE 7 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;organic substance biosynthetic process#GO:1901576;lipid modification#GO:0030258;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle membrane contact site#GO:0044232;membrane#GO:0016020;mitochondria-associated endoplasmic reticulum membrane#GO:0044233 transferase#PC00220;acetyltransferase#PC00038;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG156666|UniProtKB=T1ELZ7 T1ELZ7 20197597 PTHR11267:SF195 T-BOX PROTEIN-RELATED OPTOMOTOR-BLIND-RELATED-GENE-1, ISOFORM A sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cell fate commitment#GO:0045165;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;cell fate specification#GO:0001708;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HELRO|EnsemblGenome=HelroG174822|UniProtKB=T1F8I7 T1F8I7 20205136 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG89500|UniProtKB=T1G7D9 T1G7D9 20216986 PTHR24416:SF600 TYROSINE-PROTEIN KINASE RECEPTOR PDGF- AND VEGF-RECEPTOR RELATED, ISOFORM J signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG102816|UniProtKB=T1EDC1 T1EDC1 20194573 PTHR14187:SF46 ALPHA KINASE/ELONGATION FACTOR 2 KINASE HEAT SHOCK 70 KDA PROTEIN 12A HELRO|EnsemblGenome=HelroG176565|UniProtKB=T1FAN6 T1FAN6 20205885 PTHR13422:SF12 SIN3-HDAC COMPLEX-ASSOCIATED FACTOR SIN3-HDAC COMPLEX-ASSOCIATED FACTOR regulation of biological process#GO:0050789;negative regulation of locomotion#GO:0040013;negative regulation of biological process#GO:0048519;regulation of cell migration#GO:0030334;regulation of cell motility#GO:2000145;regulation of locomotion#GO:0040012;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;negative regulation of cell motility#GO:2000146;negative regulation of cellular process#GO:0048523;negative regulation of cell migration#GO:0030336 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;Sin3-type complex#GO:0070822;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;histone deacetylase complex#GO:0000118;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG166828|UniProtKB=T1EYL1 T1EYL1 20201661 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG98699|UniProtKB=T1G9P4 T1G9P4 20217790 PTHR24353:SF153 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;cytosol#GO:0005829;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Enkephalin release#P05913>PKA#P05972;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Endothelin signaling pathway#P00019>PKA#P00570;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059 HELRO|EnsemblGenome=HelroG192221|UniProtKB=T1FTQ4 T1FTQ4 20212201 PTHR13288:SF8 SPLICING FACTOR 45 SPF45 SPLICING FACTOR 45 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;precatalytic spliceosome#GO:0071011;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG156474|UniProtKB=T1ELX4 T1ELX4 20197574 PTHR11594:SF0 40S RIBOSOMAL PROTEIN S27 40S RIBOSOMAL PROTEIN S27 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;protein-RNA complex assembly#GO:0022618;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;ribonucleoprotein complex biogenesis#GO:0022613;protein-containing complex assembly#GO:0065003;ribosome biogenesis#GO:0042254;cellular component organization#GO:0016043;protein-RNA complex organization#GO:0071826;non-membrane-bounded organelle assembly#GO:0140694;cellular process#GO:0009987;ribosomal small subunit biogenesis#GO:0042274 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;cytosol#GO:0005829;small ribosomal subunit#GO:0015935;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG146503|UniProtKB=T1EJS7 T1EJS7 20196827 PTHR10845:SF192 REGULATOR OF G PROTEIN SIGNALING DOUBLE HIT, ISOFORM B G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731 HELRO|EnsemblGenome=HelroG191884|UniProtKB=T1FTD9 T1FTD9 20212086 PTHR22625:SF70 PLEXIN PLEXIN A, ISOFORM A transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG180242|UniProtKB=T1FFM0 T1FFM0 20207619 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED FMRFAMIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG185506|UniProtKB=T1FMW7 T1FMW7 20210166 PTHR10606:SF44 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;transferase activity, transferring phosphorus-containing groups#GO:0016772;sugar-phosphatase activity#GO:0050308;carbohydrate kinase activity#GO:0019200;kinase activity#GO:0016301;phosphoric ester hydrolase activity#GO:0042578 carbohydrate derivative metabolic process#GO:1901135;cellular metabolic process#GO:0044237;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 carbohydrate phosphatase#PC00066;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG189707|UniProtKB=T1FRA2 T1FRA2 20211349 PTHR24418:SF463 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE protein tyrosine kinase activity#GO:0004713;non-membrane spanning protein tyrosine kinase activity#GO:0004715;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein binding#GO:0005515;catalytic activity, acting on a protein#GO:0140096;signaling receptor binding#GO:0005102;kinase activity#GO:0016301;protein kinase activity#GO:0004672 response to external biotic stimulus#GO:0043207;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;immune response#GO:0006955;developmental process#GO:0032502;cell communication#GO:0007154;cellular process#GO:0009987;defense response to symbiont#GO:0140546;regulation of biological process#GO:0050789;immune system process#GO:0002376;response to stimulus#GO:0050896;response to external stimulus#GO:0009605;cell differentiation#GO:0030154;enzyme-linked receptor protein signaling pathway#GO:0007167;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to other organism#GO:0098542;regulation of cellular process#GO:0050794;response to other organism#GO:0051707;cell surface receptor signaling pathway#GO:0007166;biological process involved in interspecies interaction between organisms#GO:0044419;biological regulation#GO:0065007;innate immune response#GO:0045087;defense response#GO:0006952;signaling#GO:0023052;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG157751|UniProtKB=T1EMF4 T1EMF4 20197754 PTHR22811:SF210 TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN RE49489P endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;Golgi organization#GO:0007030;macromolecule localization#GO:0033036;transport#GO:0006810;endomembrane system organization#GO:0010256;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;organelle organization#GO:0006996;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;endoplasmic reticulum#GO:0005783;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG101749|UniProtKB=T1ED67 T1ED67 20194519 PTHR24413:SF213 SPECKLE-TYPE POZ PROTEIN FI01029P-RELATED enzyme binding#GO:0019899;protein binding#GO:0005515;ubiquitin protein ligase binding#GO:0031625;binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389 regulation of proteolysis#GO:0030162;macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;regulation of protein metabolic process#GO:0051246;macromolecule metabolic process#GO:0043170;regulation of nitrogen compound metabolic process#GO:0051171;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of biological process#GO:0050789;modification-dependent macromolecule catabolic process#GO:0043632;regulation of primary metabolic process#GO:0080090;regulation of macromolecule metabolic process#GO:0060255;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;biological regulation#GO:0065007;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;regulation of metabolic process#GO:0019222;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG190791|UniProtKB=T1FSA7 T1FSA7 20211704 PTHR45824:SF29 GH16843P GH16843P phospholipid transporter activity#GO:0005548;lipid transfer activity#GO:0120013;transporter activity#GO:0005215;lipid transporter activity#GO:0005319 HELRO|EnsemblGenome=HelroG165410|UniProtKB=T1EWQ8 T1EWQ8 20201008 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG84029|UniProtKB=T1G5D6 T1G5D6 20216283 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG91729|UniProtKB=T1G882 T1G882 20217279 PTHR13354:SF11 ROUND SPERMATID BASIC PROTEIN 1 LYSINE-SPECIFIC DEMETHYLASE 9 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185075|UniProtKB=T1FMD2 T1FMD2 20209981 PTHR11937:SF526 ACTIN ACTIN, CYTOPLASMIC 1-RELATED intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 actin and actin related protein#PC00039;cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Integrin signalling pathway#P00034>Actin#P00944;Alzheimer disease-presenilin pathway#P00004>actin#P00114;Nicotinic acetylcholine receptor signaling pathway#P00044>Actin#P01090;Huntington disease#P00029>Actin#P00807;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>F-actin#P00858;Cadherin signaling pathway#P00012>F-actin#P00470;Cytoskeletal regulation by Rho GTPase#P00016>Actin#P00512 HELRO|EnsemblGenome=HelroG62837|UniProtKB=T1FX57 T1FX57 20213405 PTHR12357:SF89 YTH YT521-B HOMOLOGY DOMAIN-CONTAINING YTH DOMAIN-CONTAINING FAMILY PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of mRNA stability#GO:0043488;regulation of catabolic process#GO:0009894;regulation of mRNA catabolic process#GO:0061013;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;positive regulation of cellular catabolic process#GO:0031331;RNA destabilization#GO:0050779;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;positive regulation of mRNA metabolic process#GO:1903313;regulation of RNA stability#GO:0043487;regulation of cellular catabolic process#GO:0031329;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;positive regulation of mRNA catabolic process#GO:0061014;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;positive regulation of catabolic process#GO:0009896;positive regulation of RNA metabolic process#GO:0051254;mRNA destabilization#GO:0061157;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;regulation of mRNA metabolic process#GO:1903311 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG64152|UniProtKB=T1FXQ3 T1FXQ3 20213601 PTHR12547:SF18 CCCH ZINC FINGER/TIS11-RELATED PROTEIN TIS11 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG79942|UniProtKB=T1G3V5 T1G3V5 20215753 PTHR24060:SF134 METABOTROPIC GLUTAMATE RECEPTOR METABOTROPIC GLUTAMATE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;adenylate cyclase inhibiting G protein-coupled glutamate receptor activity#GO:0001640;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888;glutamate receptor activity#GO:0008066 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GqPCR#P00730 HELRO|EnsemblGenome=HelroG166862|UniProtKB=T1EYN4 T1EYN4 20201684 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188933|UniProtKB=T1FQH9 T1FQH9 20211076 PTHR11705:SF91 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B FI01817P-RELATED metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metallocarboxypeptidase activity#GO:0004181;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;carboxypeptidase activity#GO:0004180 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG64249|UniProtKB=T1FXR7 T1FXR7 20213615 PTHR12381:SF56 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U FAMILY MEMBER B30.2_SPRY DOMAIN-CONTAINING PROTEIN-RELATED nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;alternative mRNA splicing, via spliceosome#GO:0000380;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG170621|UniProtKB=T1F393 T1F393 20203292 PTHR11618:SF13 TRANSCRIPTION INITIATION FACTOR IIB-RELATED TRANSCRIPTION INITIATION FACTOR IIB cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;gene expression#GO:0010467;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;aromatic compound biosynthetic process#GO:0019438;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein-containing complex#GO:0032991;protein-DNA complex#GO:0032993 general transcription factor#PC00259 Transcription regulation by bZIP transcription factor#P00055>TFIIB#P01397;General transcription regulation#P00023>TFIIB#P00668 HELRO|EnsemblGenome=HelroG173643|UniProtKB=T1F730 T1F730 20204629 PTHR11177:SF317 CHITINASE CHITINASE 12-RELATED glycosidase#PC00110;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG68110|UniProtKB=T1FZA3 T1FZA3 20214151 PTHR19139:SF199 AQUAPORIN TRANSPORTER MIP17260P cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG188839|UniProtKB=T1FQE8 T1FQE8 20211045 PTHR12587:SF20 LAR INTERACTING PROTEIN LIP -RELATED PROTEIN LIPRIN-ALPHA, ISOFORM E cellular component organization or biogenesis#GO:0071840;synapse organization#GO:0050808;cellular component organization#GO:0016043;cellular process#GO:0009987;cell junction organization#GO:0034330 cell junction#GO:0030054;presynapse#GO:0098793;synapse#GO:0045202;cellular anatomical entity#GO:0110165;presynaptic active zone#GO:0048786 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG158659|UniProtKB=T1EN36 T1EN36 20197986 PTHR18901:SF38 2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2 PSEUDOURIDINE-5'-PHOSPHATASE hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG188088|UniProtKB=T1FPM0 T1FPM0 20210767 PTHR12186:SF2 SIKE FAMILY MEMBER FGFR1 ONCOGENE PARTNER 2 HOMOLOG HELRO|EnsemblGenome=HelroG167525|UniProtKB=T1EZG3 T1EZG3 20201963 PTHR23236:SF51 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H NUCLEOLAR PROTEIN 6 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159;rRNA binding#GO:0019843 cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;ribosome biogenesis#GO:0042254;cellular process#GO:0009987;ribosomal small subunit biogenesis#GO:0042274;ribonucleoprotein complex biogenesis#GO:0022613 membrane-enclosed lumen#GO:0031974;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG164231|UniProtKB=T1EV51 T1EV51 20200451 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG161354|UniProtKB=T1ERD7 T1ERD7 20199137 PTHR24366:SF96 IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS LEUCINE RICH REPEAT CONTAINING 53 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG176474|UniProtKB=T1FAJ6 T1FAJ6 20205845 PTHR19139:SF199 AQUAPORIN TRANSPORTER MIP17260P cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG188820|UniProtKB=T1FQE3 T1FQE3 20211040 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG167310|UniProtKB=T1EZ89 T1EZ89 20201889 PTHR21208:SF1 ADP-DEPENDENT GLUCOKINASE ADP-DEPENDENT GLUCOKINASE carbohydrate metabolic process#GO:0005975;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238;metabolic process#GO:0008152 transferase#PC00220;kinase#PC00137;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG178716|UniProtKB=T1FDM2 T1FDM2 20206921 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN SI:DKEY-17M8.2 HELRO|EnsemblGenome=HelroG168139|UniProtKB=T1F078 T1F078 20202228 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG73405|UniProtKB=T1G1D6 T1G1D6 20214884 PTHR23050:SF23 CALCIUM BINDING PROTEIN AT22559P-RELATED cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule-based process#GO:0007017;organelle organization#GO:0006996 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;centriole#GO:0005814;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG192425|UniProtKB=T1FTY2 T1FTY2 20212279 PTHR15283:SF4 GREMLIN 1 BURSICON molecular function activator activity#GO:0140677;binding#GO:0005488;molecular function regulator activity#GO:0098772;cytokine binding#GO:0019955;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;protein binding#GO:0005515;signaling receptor binding#GO:0005102 regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;negative regulation of response to stimulus#GO:0048585;animal organ development#GO:0048513;developmental process#GO:0032502;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of BMP signaling pathway#GO:0030510;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;negative regulation of BMP signaling pathway#GO:0030514;anatomical structure morphogenesis#GO:0009653;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;animal organ morphogenesis#GO:0009887;regulation of cellular response to growth factor stimulus#GO:0090287;negative regulation of signal transduction#GO:0009968;negative regulation of cellular process#GO:0048523;negative regulation of cell communication#GO:0010648 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 HELRO|EnsemblGenome=HelroG194993|UniProtKB=T1FWM7 T1FWM7 20213222 PTHR10048:SF14 PHOSPHATIDYLINOSITOL KINASE LD28067P transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301;lipid kinase activity#GO:0001727 lipid metabolic process#GO:0006629;signal transduction#GO:0007165;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;glycerolipid metabolic process#GO:0046486;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular response to stimulus#GO:0051716;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;cell communication#GO:0007154;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;cell motility#GO:0048870;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0043491;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;glycerophospholipid biosynthetic process#GO:0046474;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;cell migration#GO:0016477 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;phosphatidylinositol 3-kinase complex#GO:0005942;catalytic complex#GO:1902494;transferase complex#GO:1990234;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;extrinsic component of membrane#GO:0019898 kinase#PC00137 PDGF signaling pathway#P00047>PI3K#P01168;Apoptosis signaling pathway#P00006>PI3K#P00310;Axon guidance mediated by netrin#P00009>PI3K#P00363;Hypoxia response via HIF activation#P00030>PI3K#P00823;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PI3K#P00868;Angiogenesis#P00005>PI3K#P00236;EGF receptor signaling pathway#P00018>PI3K#P00557;VEGF signaling pathway#P00056>PI3K#P01413;FGF signaling pathway#P00021>PI3K#P00640;Ras Pathway#P04393>PI3K#P04567;p53 pathway feedback loops 2#P04398>PI3K#P04661;p53 pathway#P00059>PI3K#P04609;Endothelin signaling pathway#P00019>PI3K#P00577;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PI3K#P00900;Integrin signalling pathway#P00034>PI3K#P00936 HELRO|EnsemblGenome=HelroG66723|UniProtKB=T1FYP3 T1FYP3 20213941 PTHR14624:SF0 DFG10 PROTEIN POLYPRENOL REDUCTASE oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;macromolecule modification#GO:0043412;alcohol biosynthetic process#GO:0046165;protein modification process#GO:0036211;organic hydroxy compound biosynthetic process#GO:1901617;lipid catabolic process#GO:0016042;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;cellular lipid catabolic process#GO:0044242;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;organic hydroxy compound metabolic process#GO:1901615;isoprenoid catabolic process#GO:0008300;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein glycosylation#GO:0006486;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;alcohol metabolic process#GO:0006066;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;isoprenoid metabolic process#GO:0006720;primary metabolic process#GO:0044238;isoprenoid biosynthetic process#GO:0008299;carbohydrate derivative biosynthetic process#GO:1901137;small molecule catabolic process#GO:0044282;protein N-linked glycosylation#GO:0006487;small molecule biosynthetic process#GO:0044283;cellular lipid metabolic process#GO:0044255;glycosylation#GO:0070085;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG191439|UniProtKB=T1FSZ6 T1FSZ6 20211943 PTHR21286:SF0 NUCLEAR PORE COMPLEX PROTEIN NUP160 NUCLEAR PORE COMPLEX PROTEIN NUP160 structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056 envelope#GO:0031975;nuclear pore#GO:0005643;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG67728|UniProtKB=T1FZ45 T1FZ45 20214093 PTHR21281:SF0 CYTOCHROME B5 DOMAIN-CONTAINING PROTEIN 1 CYTOCHROME B5 DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG186499|UniProtKB=T1FP02 T1FP02 20210549 PTHR12900:SF0 MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1 CHECKPOINT PROTEIN DNA repair#GO:0006281;DNA damage checkpoint signaling#GO:0000077;mitotic cell cycle checkpoint signaling#GO:0007093;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;cell cycle checkpoint signaling#GO:0000075;DNA damage response#GO:0006974;mitotic cell cycle#GO:0000278;nitrogen compound metabolic process#GO:0006807;recombinational repair#GO:0000725;reproductive process#GO:0022414;intracellular signal transduction#GO:0035556;organic substance metabolic process#GO:0071704;nucleotide-excision repair#GO:0006289;regulation of cell cycle G2/M phase transition#GO:1902749;negative regulation of cell cycle#GO:0045786;regulation of mitotic cell cycle phase transition#GO:1901990;macromolecule metabolic process#GO:0043170;meiotic cell cycle#GO:0051321;regulation of cell cycle phase transition#GO:1901987;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cell communication#GO:0007154;cellular nitrogen compound metabolic process#GO:0034641;double-strand break repair via homologous recombination#GO:0000724;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;regulation of cell cycle process#GO:0010564;cellular component organization or biogenesis#GO:0071840;response to stress#GO:0006950;reproduction#GO:0000003;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;chromosome organization#GO:0051276;regulation of cellular process#GO:0050794;mitotic G2/M transition checkpoint#GO:0044818;sexual reproduction#GO:0019953;cellular response to stress#GO:0033554;cellular aromatic compound metabolic process#GO:0006725;signal transduction#GO:0007165;negative regulation of biological process#GO:0048519;double-strand break repair#GO:0006302;telomere organization#GO:0032200;mitotic intra-S DNA damage checkpoint signaling#GO:0031573;cell cycle process#GO:0022402;negative regulation of cell cycle process#GO:0010948;mitotic cell cycle process#GO:1903047;telomere maintenance#GO:0000723;negative regulation of mitotic cell cycle phase transition#GO:1901991;organic cyclic compound metabolic process#GO:1901360;meiotic cell cycle process#GO:1903046;signal transduction in response to DNA damage#GO:0042770;mitotic DNA replication checkpoint signaling#GO:0033314;signaling#GO:0023052;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;negative regulation of cell cycle G2/M phase transition#GO:1902750;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of mitotic cell cycle#GO:0045930;cellular process#GO:0009987;DNA integrity checkpoint signaling#GO:0031570;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;organelle organization#GO:0006996;DNA replication checkpoint signaling#GO:0000076;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;mitotic DNA integrity checkpoint signaling#GO:0044774;regulation of G2/M transition of mitotic cell cycle#GO:0010389;mitotic DNA damage checkpoint signaling#GO:0044773;regulation of mitotic cell cycle#GO:0007346;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;site of DNA damage#GO:0090734;condensed chromosome#GO:0000793;intracellular organelle lumen#GO:0070013;condensed nuclear chromosome#GO:0000794;site of double-strand break#GO:0035861;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG194270|UniProtKB=T1FVV9 T1FVV9 20212955 PTHR21547:SF0 CLUSTERIN ASSOCIATED PROTEIN 1 CLUSTERIN-ASSOCIATED PROTEIN 1 organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 microtubule organizing center#GO:0005815;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;intraciliary transport particle B#GO:0030992;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cytoskeleton#GO:0005856;cilium#GO:0005929;intraciliary transport particle#GO:0030990 HELRO|EnsemblGenome=HelroG193409|UniProtKB=T1FUY8 T1FUY8 20212634 PTHR13503:SF3 NEGATIVE ELONGATION FACTOR COMPLEX MEMBER B NEGATIVE ELONGATION FACTOR B HELRO|EnsemblGenome=HelroG106040|UniProtKB=T1EDZ5 T1EDZ5 20194797 PTHR22872:SF2 BTK-BINDING PROTEIN-RELATED INHIBITOR OF BRUTON TYROSINE KINASE HELRO|EnsemblGenome=HelroG168788|UniProtKB=T1F0Z1 T1F0Z1 20202491 PTHR15440:SF0 XRP2 PROTEIN PROTEIN XRP2 nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;Golgi vesicle transport#GO:0048193;post-Golgi vesicle-mediated transport#GO:0006892;transport#GO:0006810 membrane-bounded organelle#GO:0043227;plasma membrane region#GO:0098590;cell projection#GO:0042995;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;cilium#GO:0005929;organelle#GO:0043226;plasma membrane#GO:0005886 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG179366|UniProtKB=T1FEM0 T1FEM0 20207269 PTHR11616:SF321 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;organic acid:sodium symporter activity#GO:0005343;organic acid transmembrane transporter activity#GO:0005342;symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;organic anion transmembrane transporter activity#GO:0008514;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;amino acid:sodium symporter activity#GO:0005283;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;amino acid transmembrane transporter activity#GO:0015171;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;organic anion transport#GO:0015711;amino acid transport#GO:0006865;organic acid transport#GO:0015849;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;nitrogen compound transport#GO:0071705;carboxylic acid transport#GO:0046942;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;amino acid import across plasma membrane#GO:0089718;carboxylic acid transmembrane transport#GO:1905039;localization#GO:0051179;organic substance transport#GO:0071702;import across plasma membrane#GO:0098739;amino acid transmembrane transport#GO:0003333;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transport#GO:0006812;organic acid transmembrane transport#GO:1903825;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>CHT1#P01084 HELRO|EnsemblGenome=HelroG67929|UniProtKB=T1FZ79 T1FZ79 20214127 PTHR45788:SF4 SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;organic acid transmembrane transporter activity#GO:0005342;citrate transmembrane transporter activity#GO:0015137;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;mitochondrial transport#GO:0006839;organic substance transport#GO:0071702;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;organic acid transmembrane transport#GO:1903825;cellular process#GO:0009987;mitochondrial transmembrane transport#GO:1990542;citrate transport#GO:0015746;tricarboxylic acid transport#GO:0006842;carboxylic acid transmembrane transport#GO:1905039 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG184607|UniProtKB=T1FLK7 T1FLK7 20209706 PTHR21207:SF2 PARKIN COREGULATED GENE PROTEIN PARK2 COREGULATED PARKIN COREGULATED GENE PROTEIN heat shock protein binding#GO:0031072;protein binding#GO:0005515;protein-folding chaperone binding#GO:0051087;binding#GO:0005488;Hsp70 protein binding#GO:0030544;Hsp90 protein binding#GO:0051879 HELRO|EnsemblGenome=HelroG185729|UniProtKB=T1FN75 T1FN75 20210273 PTHR12192:SF2 CATION TRANSPORT PROTEIN CHAC-RELATED GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2 lyase activity#GO:0016829;catalytic activity#GO:0003824 sulfur compound metabolic process#GO:0006790;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;peptide catabolic process#GO:0043171;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;cellular process#GO:0009987;glutathione metabolic process#GO:0006749;sulfur compound catabolic process#GO:0044273;nitrogen compound metabolic process#GO:0006807;cellular modified amino acid metabolic process#GO:0006575;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG81466|UniProtKB=T1G4E6 T1G4E6 20215944 PTHR24082:SF473 NUCLEAR HORMONE RECEPTOR ECDYSONE-INDUCED PROTEIN 75B, ISOFORM B cis-regulatory region sequence-specific DNA binding#GO:0000987;signaling receptor activity#GO:0038023;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;signal transduction#GO:0007165;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of RNA metabolic process#GO:0051253;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;hormone-mediated signaling pathway#GO:0009755;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;positive regulation of biosynthetic process#GO:0009891;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of transcription by RNA polymerase II#GO:0000122;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;response to organic substance#GO:0010033;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;cellular response to endogenous stimulus#GO:0071495;negative regulation of biosynthetic process#GO:0009890;cellular response to chemical stimulus#GO:0070887;regulation of DNA-templated transcription#GO:0006355;cellular response to organic substance#GO:0071310;negative regulation of metabolic process#GO:0009892;cell communication#GO:0007154;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;negative regulation of nitrogen compound metabolic process#GO:0051172;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;negative regulation of macromolecule biosynthetic process#GO:0010558;response to hormone#GO:0009725;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;response to chemical#GO:0042221;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG166313|UniProtKB=T1EY05 T1EY05 20201455 PTHR34203:SF15 METHYLTRANSFERASE, FKBM FAMILY PROTEIN SLL1173 PROTEIN methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG107973|UniProtKB=T1EEE5 T1EEE5 20194947 PTHR44086:SF10 THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3 thiosulfate sulfurtransferase activity#GO:0004792;transferase activity#GO:0016740;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity#GO:0003824;sulfurtransferase activity#GO:0016783 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG186068|UniProtKB=T1FNM4 T1FNM4 20210421 PTHR10660:SF2 PROTEASOME REGULATOR PA28 LD45860P peptidase activator activity#GO:0016504;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of protein metabolic process#GO:0051246;regulation of catabolic process#GO:0009894;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of molecular function#GO:0044093;regulation of protein catabolic process#GO:0042176;regulation of proteolysis involved in protein catabolic process#GO:1903050;regulation of catalytic activity#GO:0050790;positive regulation of proteolysis#GO:0045862;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;regulation of hydrolase activity#GO:0051336;regulation of G1/S transition of mitotic cell cycle#GO:2000045;positive regulation of peptidase activity#GO:0010952;positive regulation of biological process#GO:0048518;regulation of proteolysis#GO:0030162;regulation of mitotic cell cycle phase transition#GO:1901990;positive regulation of catalytic activity#GO:0043085;regulation of cell cycle phase transition#GO:1901987;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of hydrolase activity#GO:0051345;regulation of cell cycle process#GO:0010564;regulation of primary metabolic process#GO:0080090;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of protein metabolic process#GO:0051247;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;regulation of endopeptidase activity#GO:0052548;regulation of peptidase activity#GO:0052547;regulation of mitotic cell cycle#GO:0007346;positive regulation of endopeptidase activity#GO:0010950;regulation of cell cycle G1/S phase transition#GO:1902806;regulation of metabolic process#GO:0019222 membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG144444|UniProtKB=T1EJE8 T1EJE8 20196698 PTHR11040:SF140 ZINC/IRON TRANSPORTER ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;transition metal ion transport#GO:0000041;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG156424|UniProtKB=T1ELW2 T1ELW2 20197562 PTHR15599:SF1 RTDR1 RADIAL SPOKE HEAD 14 HOMOLOG HELRO|EnsemblGenome=HelroG114837|UniProtKB=T1EG48 T1EG48 20195550 PTHR11360:SF286 MONOCARBOXYLATE TRANSPORTER GH22266P transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;monocarboxylic acid transmembrane transporter activity#GO:0008028;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;monocarboxylic acid transport#GO:0015718;establishment of localization#GO:0051234;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942 transporter#PC00227 HELRO|EnsemblGenome=HelroG193555|UniProtKB=T1FV46 T1FV46 20212692 PTHR10394:SF3 40S RIBOSOMAL PROTEIN S8 SMALL RIBOSOMAL SUBUNIT PROTEIN ES8 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;cytosol#GO:0005829;small ribosomal subunit#GO:0015935;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG70775|UniProtKB=T1G0C0 T1G0C0 20214518 PTHR13439:SF4 CT120 PROTEIN TLC DOMAIN-CONTAINING PROTEIN cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;membrane assembly#GO:0071709;regulation of biological quality#GO:0065008;membrane organization#GO:0061024;plasma membrane organization#GO:0007009;biological regulation#GO:0065007;lipid homeostasis#GO:0055088;endomembrane system organization#GO:0010256;homeostatic process#GO:0042592;cellular component organization#GO:0016043;regulation of membrane lipid distribution#GO:0097035;chemical homeostasis#GO:0048878;cellular process#GO:0009987 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG99551|UniProtKB=T1G9T4 T1G9T4 20217830 PTHR12629:SF0 DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG86877|UniProtKB=T1G6I6 T1G6I6 20216683 PTHR11661:SF1 60S RIBOSOMAL PROTEIN L12 LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;rRNA binding#GO:0019843;binding#GO:0005488;organic cyclic compound binding#GO:0097159 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;large ribosomal subunit#GO:0015934;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG188507|UniProtKB=T1FQ26 T1FQ26 20210923 PTHR21559:SF21 DYSTROGLYCAN-RELATED DYSTROGLYCAN 1 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG109692|UniProtKB=T1EEV7 T1EEV7 20195109 PTHR43107:SF15 LONG-CHAIN FATTY ACID TRANSPORT PROTEIN FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A long-chain fatty acid-CoA ligase activity#GO:0004467;ligase activity#GO:0016874;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;ATP-dependent activity#GO:0140657;organic acid transmembrane transporter activity#GO:0005342;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877;monocarboxylic acid transmembrane transporter activity#GO:0008028;organic anion transmembrane transporter activity#GO:0008514;lipid transporter activity#GO:0005319;transporter activity#GO:0005215 long-chain fatty acid metabolic process#GO:0001676;oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;monocarboxylic acid transport#GO:0015718;macromolecule localization#GO:0033036;organic anion transport#GO:0015711;organic acid transport#GO:0015849;fatty acid transport#GO:0015908;transport#GO:0006810;carboxylic acid transport#GO:0046942;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;lipid transport#GO:0006869;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;localization#GO:0051179;organic substance transport#GO:0071702;fatty acid metabolic process#GO:0006631;establishment of localization#GO:0051234;lipid localization#GO:0010876;cellular lipid metabolic process#GO:0044255;carboxylic acid metabolic process#GO:0019752;import into cell#GO:0098657;long-chain fatty acid transport#GO:0015909;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG183847|UniProtKB=T1FK95 T1FK95 20209244 PTHR15704:SF7 SUPERKILLER 3 PROTEIN-RELATED SUPERKILLER COMPLEX PROTEIN 3 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;mRNA catabolic process#GO:0006402;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;organic substance catabolic process#GO:1901575;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;nuclear-transcribed mRNA catabolic process#GO:0000956;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG114122|UniProtKB=T1EFZ2 T1EFZ2 20195494 PTHR10288:SF171 KH DOMAIN CONTAINING RNA BINDING PROTEIN P-ELEMENT SOMATIC INHIBITOR, ISOFORM C nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG108618|UniProtKB=T1EEL1 T1EEL1 20195013 PTHR12450:SF22 DENTIN MATRIX PROTEIN 4 PROTEIN FAM20 EXTRACELLULAR SERINE_THREONINE PROTEIN CG31145 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG69928|UniProtKB=T1G000 T1G000 20214398 PTHR24418:SF294 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE BTK29A protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG188208|UniProtKB=T1FPS0 T1FPS0 20210817 PTHR10527:SF5 IMPORTIN BETA IMPORTIN 5 signal sequence binding#GO:0005048;binding#GO:0005488;amide binding#GO:0033218;peptide binding#GO:0042277 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;protein import into nucleus#GO:0006606;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;protein localization to organelle#GO:0033365;intracellular transport#GO:0046907;nuclear transport#GO:0051169;import into nucleus#GO:0051170 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG172250|UniProtKB=T1F559 T1F559 20203958 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG194253|UniProtKB=T1FVV3 T1FVV3 20212949 PTHR21448:SF0 SMOOTH MUSCLE MYOSIN HEAVY CHAIN-RELATED PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 21 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG88759|UniProtKB=T1G761 T1G761 20216908 PTHR13302:SF8 CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3 localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;Golgi organization#GO:0007030;establishment of localization#GO:0051234;intra-Golgi vesicle-mediated transport#GO:0006891;organelle organization#GO:0006996;transport#GO:0006810;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;vesicle tethering complex#GO:0099023;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;Golgi transport complex#GO:0017119;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG108802|UniProtKB=T1EEM6 T1EEM6 20195028 PTHR12674:SF2 PREFOLDIN SUBUNIT 5 PREFOLDIN SUBUNIT 5 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG92352|UniProtKB=T1G8E8 T1G8E8 20217345 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG183522|UniProtKB=T1FJS3 T1FJS3 20209072 PTHR11003:SF334 POTASSIUM CHANNEL, SUBFAMILY K FI03418P monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG155662|UniProtKB=T1ELK0 T1ELK0 20197450 PTHR10658:SF11 PHOSPHATIDYLINOSITOL TRANSFER PROTEIN VIBRATOR, ISOFORM B transporter#PC00227 HELRO|EnsemblGenome=HelroG170685|UniProtKB=T1F3B4 T1F3B4 20203313 PTHR23055:SF178 CALCIUM BINDING PROTEINS NEUROCALCIN HOMOLOG cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG77679|UniProtKB=T1G323 T1G323 20215471 PTHR24083:SF46 NUCLEAR HORMONE RECEPTOR STEROID RECEPTOR SEVEN-UP, ISOFORM A cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;signaling receptor activity#GO:0038023;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG157814|UniProtKB=T1EMG3 T1EMG3 20197763 PTHR13399:SF2 TRANSLOCON-ASSOCIATED PROTEIN TRAP , GAMMA SUBUNIT TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT GAMMA cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG179236|UniProtKB=T1FEE7 T1FEE7 20207196 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cell communication#GO:0007154;cellular process#GO:0009987;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;Notch signaling pathway#GO:0007219 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG174220|UniProtKB=T1F7T9 T1F7T9 20204888 PTHR46601:SF1 ULP_PROTEASE DOMAIN-CONTAINING PROTEIN ADF-H DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG110990|UniProtKB=T1EF69 T1EF69 20195221 PTHR10218:SF360 GTP-BINDING PROTEIN ALPHA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;ribonucleoside triphosphate phosphatase activity#GO:0017111;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 regulation of biological process#GO:0050789;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;side of membrane#GO:0098552;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;extrinsic component of membrane#GO:0019898 heterotrimeric G-protein#PC00117;G-protein#PC00020 HELRO|EnsemblGenome=HelroG183124|UniProtKB=T1FJ60 T1FJ60 20208859 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG155870|UniProtKB=T1ELN5 T1ELN5 20197485 PTHR42752:SF1 IMIDAZOLONEPROPIONASE IMIDAZOLONEPROPIONASE-RELATED hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides#GO:0016812;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;organic acid catabolic process#GO:0016054;amino acid catabolic process#GO:0009063;small molecule catabolic process#GO:0044282;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;carboxylic acid metabolic process#GO:0019752;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;cellular catabolic process#GO:0044248 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG94263|UniProtKB=T1G8Z8 T1G8Z8 20217545 PTHR21311:SF0 CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;Golgi vesicle transport#GO:0048193;intra-Golgi vesicle-mediated transport#GO:0006891;transport#GO:0006810 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;vesicle tethering complex#GO:0099023;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;Golgi transport complex#GO:0017119;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG172160|UniProtKB=T1F533 T1F533 20203932 PTHR24543:SF291 MULTICOPPER OXIDASE-RELATED SMOKE ALARM, ISOFORM D oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG186668|UniProtKB=T1FP21 T1FP21 20210568 PTHR23504:SF31 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG194424|UniProtKB=T1FW16 T1FW16 20213012 PTHR19282:SF562 TETRASPANIN AT12771P-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG168375|UniProtKB=T1F0I2 T1F0I2 20202332 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG178740|UniProtKB=T1FDN5 T1FDN5 20206934 PTHR20916:SF18 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN IPT_TIG DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176001|UniProtKB=T1FA06 T1FA06 20205655 PTHR13066:SF2 BASIC LEUCINE ZIPPER NUCLEAR FACTOR 1 BLZF1 PROTEIN GOLGIN-45 protein localization to plasma membrane#GO:0072659;localization within membrane#GO:0051668;cellular localization#GO:0051641;vesicle-mediated transport to the plasma membrane#GO:0098876;Golgi organization#GO:0007030;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;post-Golgi vesicle-mediated transport#GO:0006892;transport#GO:0006810;endomembrane system organization#GO:0010256;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;establishment of protein localization#GO:0045184;Golgi to plasma membrane transport#GO:0006893;protein localization#GO:0008104;localization#GO:0051179;protein localization to cell periphery#GO:1990778;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;establishment of protein localization to membrane#GO:0090150;Golgi to plasma membrane protein transport#GO:0043001;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;organelle organization#GO:0006996;protein transport#GO:0015031 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;basic leucine zipper transcription factor#PC00056 HELRO|EnsemblGenome=HelroG158446|UniProtKB=T1EMS9 T1EMS9 20197879 PTHR47577:SF2 THAP DOMAIN-CONTAINING PROTEIN 6 THAP DOMAIN CONTAINING 9 HELRO|EnsemblGenome=HelroG160039|UniProtKB=T1EPP8 T1EPP8 20198548 PTHR11801:SF67 SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION SUBFAMILY NOT NAMED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HELRO|EnsemblGenome=HelroG188754|UniProtKB=T1FQB8 T1FQB8 20211015 PTHR46989:SF3 USP DOMAIN-CONTAINING PROTEIN USPA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG76765|UniProtKB=T1G2P1 T1G2P1 20215339 PTHR12989:SF10 ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10 DOL-P-GLC:GLC(2)MAN(9)GLCNAC(2)-PP-DOL ALPHA-1,2-GLUCOSYLTRANSFERASE-RELATED glucosyltransferase activity#GO:0046527;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG164934|UniProtKB=T1EVZ5 T1EVZ5 20200745 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182146|UniProtKB=T1FHT9 T1FHT9 20208388 PTHR13297:SF9 TBC1 DOMAIN FAMILY MEMBER 23-RELATED ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG174433|UniProtKB=T1F843 T1F843 20204992 PTHR11675:SF131 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 9-RELATED transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG83734|UniProtKB=T1G599 T1G599 20216246 PTHR28668:SF1 TRANSMEMBRANE PROTEIN 234 TRANSMEMBRANE PROTEIN 234 HELRO|EnsemblGenome=HelroG175491|UniProtKB=T1F9B7 T1F9B7 20205416 PTHR21461:SF69 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 glycosylation#GO:0070085;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG155593|UniProtKB=T1ELJ4 T1ELJ4 20197444 PTHR24056:SF254 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 2 transferase activity#GO:0016740;cyclin-dependent protein kinase activity#GO:0097472;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein serine/threonine kinase activity#GO:0004674;protein binding#GO:0005515;cyclin binding#GO:0030332;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 signal transduction#GO:0007165;mitotic cell cycle phase transition#GO:0044772;macromolecule modification#GO:0043412;cell cycle G1/S phase transition#GO:0044843;cell cycle process#GO:0022402;protein modification process#GO:0036211;mitotic cell cycle process#GO:1903047;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;G1/S transition of mitotic cell cycle#GO:0000082;regulation of biological process#GO:0050789;mitotic cell cycle#GO:0000278;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;phosphorylation#GO:0016310;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;regulation of cell cycle G2/M phase transition#GO:1902749;regulation of mitotic cell cycle phase transition#GO:1901990;macromolecule metabolic process#GO:0043170;regulation of cell cycle phase transition#GO:1901987;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;cell cycle phase transition#GO:0044770;primary metabolic process#GO:0044238;regulation of cell cycle process#GO:0010564;response to stimulus#GO:0050896;regulation of cellular biosynthetic process#GO:0031326;response to chemical#GO:0042221;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of G2/M transition of mitotic cell cycle#GO:0010389;regulation of mitotic cell cycle#GO:0007346;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695 non-receptor serine/threonine protein kinase#PC00167 EGF receptor signaling pathway#P00018>ERK1-2#P00543;p53 pathway#P00059>Cdc2#P04634;p53 pathway feedback loops 2#P04398>cdk2#P04653;p53 pathway#P00059>Cdk2#P04625 HELRO|EnsemblGenome=HelroG187961|UniProtKB=T1FPI3 T1FPI3 20210730 PTHR12790:SF0 TRANSCRIPTION INITIATION FACTOR IA RRN3 RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED enzyme binding#GO:0019899;protein binding#GO:0005515;RNA polymerase binding#GO:0070063;binding#GO:0005488;RNA polymerase core enzyme binding#GO:0043175 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;transcription by RNA polymerase I#GO:0006360;organic cyclic compound metabolic process#GO:1901360;nucleobase-containing compound biosynthetic process#GO:0034654;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;aromatic compound biosynthetic process#GO:0019438;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 General transcription by RNA polymerase I#P00022>RNA Polymerase I Complex#P00652 HELRO|EnsemblGenome=HelroG167194|UniProtKB=T1EZ46 T1EZ46 20201846 PTHR46273:SF4 MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED AT19640P signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG191885|UniProtKB=T1FTE0 T1FTE0 20212087 PTHR24023:SF1105 COLLAGEN ALPHA FIBRILLAR COLLAGEN NC1 DOMAIN-CONTAINING PROTEIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG188905|UniProtKB=T1FQG7 T1FQG7 20211064 PTHR12107:SF0 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT STARGAZIN (MAMMALIAN CALCIUM CHANNEL) HOMOLOG calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;voltage-gated channel activity#GO:0022832;molecular function regulator activity#GO:0098772;transporter regulator activity#GO:0141108;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;channel regulator activity#GO:0016247;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;inorganic cation transmembrane transporter activity#GO:0022890 cellular localization#GO:0051641;macromolecule localization#GO:0033036;receptor internalization#GO:0031623;system process#GO:0003008;transport#GO:0006810;regulation of signaling#GO:0023051;nitrogen compound transport#GO:0071705;regulation of localization#GO:0032879;endosome to lysosome transport#GO:0008333;lysosomal transport#GO:0007041;establishment of protein localization#GO:0045184;regulation of biological process#GO:0050789;organic substance transport#GO:0071702;regulation of transport#GO:0051049;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;regulation of molecular function#GO:0065009;regulation of signal transduction#GO:0009966;receptor-mediated endocytosis#GO:0006898;regulation of monoatomic ion transmembrane transporter activity#GO:0032412;regulation of transmembrane transporter activity#GO:0022898;protein localization to organelle#GO:0033365;regulation of transporter activity#GO:0032409;positive regulation of signaling#GO:0023056;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;positive regulation of biological process#GO:0048518;localization within membrane#GO:0051668;regulation of cell communication#GO:0010646;establishment of protein localization to vacuole#GO:0072666;regulation of transmembrane transport#GO:0034762;vacuolar transport#GO:0007034;endocytosis#GO:0006897;protein localization to vacuole#GO:0072665;vesicle-mediated transport#GO:0016192;establishment of protein localization to organelle#GO:0072594;nervous system process#GO:0050877;cell communication#GO:0007154;cellular process#GO:0009987;regulation of synaptic transmission, glutamatergic#GO:0051966;protein localization#GO:0008104;positive regulation of cellular process#GO:0048522;localization#GO:0051179;regulation of response to stimulus#GO:0048583;protein localization to lysosome#GO:0061462;cellular macromolecule localization#GO:0070727;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;positive regulation of cell communication#GO:0010647;protein transport#GO:0015031;biological regulation#GO:0065007;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;regulation of trans-synaptic signaling#GO:0099177;multicellular organismal process#GO:0032501;intracellular transport#GO:0046907;positive regulation of synaptic transmission#GO:0050806;import into cell#GO:0098657;protein-containing complex localization#GO:0031503 membrane protein complex#GO:0098796;synapse#GO:0045202;postsynaptic specialization#GO:0099572;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;plasma membrane signaling receptor complex#GO:0098802;transporter complex#GO:1990351;plasma membrane protein complex#GO:0098797;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;neuron to neuron synapse#GO:0098984;membrane#GO:0016020;synaptic membrane#GO:0097060;asymmetric synapse#GO:0032279;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;transmembrane transporter complex#GO:1902495;postsynaptic density membrane#GO:0098839;postsynaptic specialization membrane#GO:0099634;plasma membrane region#GO:0098590;postsynapse#GO:0098794;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG63069|UniProtKB=T1FXA7 T1FXA7 20213455 PTHR22914:SF42 CHITIN SYNTHASE CHITIN SYNTHASE acetylglucosaminyltransferase activity#GO:0008375;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758 carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;aminoglycan biosynthetic process#GO:0006023;amino sugar metabolic process#GO:0006040;aminoglycan metabolic process#GO:0006022;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;cell septum#GO:0030428 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG135084|UniProtKB=T1EI69 T1EI69 20196269 PTHR14021:SF15 IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB chaperone#PC00072 HELRO|EnsemblGenome=HelroG65077|UniProtKB=T1FY29 T1FY29 20213727 PTHR11092:SF0 SUGAR NUCLEOTIDE EPIMERASE RELATED EPIMERASE FAMILY PROTEIN SDR39U1 epimerase/racemase#PC00096;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG158525|UniProtKB=T1EMW8 T1EMW8 20197918 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190836|UniProtKB=T1FSC5 T1FSC5 20211722 PTHR23116:SF29 PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED PDZ DOMAIN-CONTAINING PROTEIN 7 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG186061|UniProtKB=T1FNM1 T1FNM1 20210418 PTHR43226:SF4 XAA-PRO AMINOPEPTIDASE 3 XAA-PRO AMINOPEPTIDASE 3 hydrolase activity#GO:0016787;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;metabolic process#GO:0008152;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG178225|UniProtKB=T1FCY6 T1FCY6 20206685 PTHR12271:SF66 POLY A POLYMERASE CID PAP -RELATED TERMINAL URIDYLYLTRANSFERASE TAILOR catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 nucleotidyltransferase#PC00174 HELRO|EnsemblGenome=HelroG173210|UniProtKB=T1F6K7 T1F6K7 20204456 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG90340|UniProtKB=T1G7P4 T1G7P4 20217091 PTHR14517:SF6 RIB43A-RELATED RE41410P cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG95985|UniProtKB=T1G997 T1G997 20217644 PTHR11773:SF1 GLYCINE DEHYDROGENASE, DECARBOXYLATING GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL cation binding#GO:0043169;amino acid binding#GO:0016597;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;carboxylic acid binding#GO:0031406;heterocyclic compound binding#GO:1901363;organic acid binding#GO:0043177;ion binding#GO:0043167;anion binding#GO:0043168;oxidoreductase activity#GO:0016491 oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;amino acid catabolic process#GO:0009063;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;nitrogen compound metabolic process#GO:0006807;alpha-amino acid metabolic process#GO:1901605;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;L-amino acid metabolic process#GO:0170033;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;oxidoreductase complex#GO:1990204;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG62184|UniProtKB=T1FWW7 T1FWW7 20213315 PTHR11134:SF1 ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER AP-3 COMPLEX SUBUNIT BETA localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;cellular process#GO:0009987;transport#GO:0006810 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG184400|UniProtKB=T1FL45 T1FL45 20209544 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189512|UniProtKB=T1FR42 T1FR42 20211289 PTHR23423:SF21 ORGANIC SOLUTE TRANSPORTER-RELATED ORGANIC SOLUTE TRANSPORTER SUBUNIT ALPHA-LIKE localization#GO:0051179;establishment of localization#GO:0051234;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG163070|UniProtKB=T1ETM4 T1ETM4 20199924 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG141144|UniProtKB=T1EJ27 T1EJ27 20196577 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;heme binding#GO:0020037 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG100575|UniProtKB=T1ED06 T1ED06 20194458 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG175878|UniProtKB=T1F9T6 T1F9T6 20205585 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG155962|UniProtKB=T1ELP8 T1ELP8 20197498 PTHR24412:SF466 KELCH PROTEIN RING CANAL KELCH PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194315|UniProtKB=T1FVX2 T1FVX2 20212968 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG164648|UniProtKB=T1EVP1 T1EVP1 20200641 PTHR12365:SF7 SPROUTY PROTEIN SPROUTY negative regulation of cellular metabolic process#GO:0031324;regulation of MAPK cascade#GO:0043408;negative regulation of biological process#GO:0048519;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of intracellular signal transduction#GO:1902532;animal organ development#GO:0048513;developmental process#GO:0032502;regulation of signaling#GO:0023051;regulation of catalytic activity#GO:0050790;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;negative regulation of protein phosphorylation#GO:0001933;negative regulation of protein modification process#GO:0031400;negative regulation of MAPK cascade#GO:0043409;regulation of molecular function#GO:0065009;regulation of signal transduction#GO:0009966;regulation of protein serine/threonine kinase activity#GO:0071900;regulation of cellular response to growth factor stimulus#GO:0090287;negative regulation of small GTPase mediated signal transduction#GO:0051058;negative regulation of protein kinase activity#GO:0006469;regulation of MAP kinase activity#GO:0043405;negative regulation of cellular process#GO:0048523;negative regulation of cell communication#GO:0010648;regulation of kinase activity#GO:0043549;regulation of protein kinase activity#GO:0045859;regulation of cell communication#GO:0010646;negative regulation of response to stimulus#GO:0048585;negative regulation of phosphorus metabolic process#GO:0010563;negative regulation of signaling#GO:0023057;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of response to stimulus#GO:0048583;regulation of primary metabolic process#GO:0080090;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of phosphorylation#GO:0042326;regulation of protein phosphorylation#GO:0001932;anatomical structure development#GO:0048856;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of phosphate metabolic process#GO:0045936;negative regulation of signal transduction#GO:0009968;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;negative regulation of catalytic activity#GO:0043086;regulation of metabolic process#GO:0019222;negative regulation of molecular function#GO:0044092;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 EGF receptor signaling pathway#P00018>Spry#P00541;EGF receptor signaling pathway#P00018>SPRY#G01511;FGF signaling pathway#P00021>Spry#P00626 HELRO|EnsemblGenome=HelroG167916|UniProtKB=T1EZY4 T1EZY4 20202134 PTHR32510:SF3 TRANSMEMBRANE PROTEIN 98 TRANSMEMBRANE PROTEIN 98 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG110019|UniProtKB=T1EEY3 T1EEY3 20195135 PTHR23050:SF510 CALCIUM BINDING PROTEIN CALMODULIN-LIKE PROTEIN 3 cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Calmodulin#P00755 HELRO|EnsemblGenome=HelroG62767|UniProtKB=T1FX50 T1FX50 20213398 PTHR45867:SF3 PURPLE ACID PHOSPHATASE ACID PHOSPHATASE TYPE 7 phosphatase#PC00181 HELRO|EnsemblGenome=HelroG179748|UniProtKB=T1FF42 T1FF42 20207441 PTHR11893:SF36 INNEXIN INNEXIN-5 cell junction protein#PC00070;gap junction#PC00105 HELRO|EnsemblGenome=HelroG190953|UniProtKB=T1FSG4 T1FSG4 20211761 PTHR11932:SF174 CULLIN CULLIN-2 enzyme binding#GO:0019899;protein binding#GO:0005515;ubiquitin protein ligase binding#GO:0031625;binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Parkinson disease#P00049>Cul-1#P01239 HELRO|EnsemblGenome=HelroG64432|UniProtKB=T1FXU6 T1FXU6 20213644 PTHR14167:SF76 SH3 DOMAIN-CONTAINING ENDOPHILIN B, ISOFORM A cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cellular process#GO:0009987;membrane organization#GO:0061024 cellular anatomical entity#GO:0110165;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG186248|UniProtKB=T1FNV1 T1FNV1 20210498 PTHR12507:SF3 REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED RAB6A-GEF COMPLEX PARTNER PROTEIN 2 localization#GO:0051179;endosomal transport#GO:0016197;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular process#GO:0009987;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147 bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;Golgi membrane#GO:0000139;guanyl-nucleotide exchange factor complex#GO:0032045 HELRO|EnsemblGenome=HelroG156173|UniProtKB=T1ELS2 T1ELS2 20197522 PTHR21016:SF7 BETA-AMYLOID BINDING PROTEIN-RELATED TM2 DOMAIN-CONTAINING PROTEIN 3 HELRO|EnsemblGenome=HelroG62692|UniProtKB=T1FX36 T1FX36 20213384 PTHR12663:SF0 ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;mitotic sister chromatid cohesion#GO:0007064;macromolecule metabolic process#GO:0043170;cell cycle process#GO:0022402;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;sister chromatid cohesion#GO:0007062;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;organelle organization#GO:0006996;chromosome organization#GO:0051276;nitrogen compound metabolic process#GO:0006807;cell cycle#GO:0007049;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG178473|UniProtKB=T1FD80 T1FD80 20206779 PTHR46123:SF4 MIX-TYPE HOMEOBOX GENE 1-RELATED MIX-TYPE HOMEOBOX GENE 1-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG178859|UniProtKB=T1FDT9 T1FDT9 20206988 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168352|UniProtKB=T1F0G2 T1F0G2 20202312 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG162363|UniProtKB=T1ESK4 T1ESK4 20199554 PTHR13283:SF10 KREV INTERACTION TRAPPED 1-RELATED FERM DOMAIN-CONTAINING PROTEIN 8 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG180238|UniProtKB=T1FFL9 T1FFL9 20207618 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG192468|UniProtKB=T1FTZ7 T1FTZ7 20212294 PTHR15904:SF17 FAM13 RHO-GAP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG91618|UniProtKB=T1G863 T1G863 20217260 PTHR23349:SF42 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST BHLH DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG166087|UniProtKB=T1EXQ7 T1EXQ7 20201357 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG108086|UniProtKB=T1EEF2 T1EEF2 20194954 PTHR44489:SF11 FAMILY NOT NAMED WD REPEAT DOMAIN 86 HELRO|EnsemblGenome=HelroG110739|UniProtKB=T1EF49 T1EF49 20195201 PTHR11958:SF63 SODIUM/DICARBOXYLATE SYMPORTER-RELATED AMINO ACID TRANSPORTER primary active transporter#PC00068;transporter#PC00227 Ionotropic glutamate receptor pathway#P00037>EAAT#P01011;Metabotropic glutamate receptor group III pathway#P00039>EAAT#P01036 HELRO|EnsemblGenome=HelroG127402|UniProtKB=T1EHE5 T1EHE5 20195995 PTHR24341:SF6 HOMEOBOX PROTEIN ENGRAILED HOMEOBOX PROTEIN INVECTED homeodomain transcription factor#PC00119 Wnt signaling pathway#P00057>Wnt Target Genes#G01558 HELRO|EnsemblGenome=HelroG161820|UniProtKB=T1ERY1 T1ERY1 20199331 PTHR14387:SF0 THADA/DEATH RECEPTOR INTERACTING PROTEIN DUF2428 DOMAIN-CONTAINING PROTEIN cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;macromolecule methylation#GO:0043414;tRNA methylation#GO:0030488;organic cyclic compound metabolic process#GO:1901360;methylation#GO:0032259;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;RNA methylation#GO:0001510;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG163969|UniProtKB=T1EUP4 T1EUP4 20200294 PTHR45995:SF1 FAMILY NOT NAMED PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 4 HELRO|EnsemblGenome=HelroG81938|UniProtKB=T1G4K7 T1G4K7 20216005 PTHR23257:SF947 SERINE-THREONINE PROTEIN KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG85430|UniProtKB=T1G5X0 T1G5X0 20216467 PTHR10334:SF498 CYSTEINE-RICH SECRETORY PROTEIN-RELATED MIP16674P defense/immunity protein#PC00090 PI3 kinase pathway#P00048>scl-1#G01545 HELRO|EnsemblGenome=HelroG178526|UniProtKB=T1FDB2 T1FDB2 20206811 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG122760|UniProtKB=T1EGV6 T1EGV6 20195806 PTHR12974:SF36 PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN 44 POLYNUCLEOTIDE ADENYLYLTRANSFERASE adenylyltransferase activity#GO:0070566;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;transferase activity#GO:0016740;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772 positive regulation of gene expression#GO:0010628;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of mRNA stability#GO:0043488;regulation of catabolic process#GO:0009894;regulation of mRNA catabolic process#GO:0061013;negative regulation of RNA metabolic process#GO:0051253;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;regulation of biosynthetic process#GO:0009889;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;mRNA stabilization#GO:0048255;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;RNA stabilization#GO:0043489;negative regulation of cellular catabolic process#GO:0031330;negative regulation of metabolic process#GO:0009892;positive regulation of cellular biosynthetic process#GO:0031328;regulation of RNA stability#GO:0043487;regulation of cellular catabolic process#GO:0031329;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;negative regulation of catabolic process#GO:0009895;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of RNA catabolic process#GO:1902369;regulation of metabolic process#GO:0019222;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323 HELRO|EnsemblGenome=HelroG177705|UniProtKB=T1FC41 T1FC41 20206390 PTHR11733:SF133 ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED PHOSPHATE-REGULATING NEUTRAL ENDOPEPTIDASE PHEX hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Endothelin signaling pathway#P00019>ECE1-3#P00585 HELRO|EnsemblGenome=HelroG107800|UniProtKB=T1EEC7 T1EEC7 20194929 PTHR13759:SF1 TWINFILIN TWINFILIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin monomer binding#GO:0003785;actin filament binding#GO:0051015 negative regulation of protein polymerization#GO:0032272;cellular localization#GO:0051641;negative regulation of protein depolymerization#GO:1901880;negative regulation of biological process#GO:0048519;negative regulation of actin filament depolymerization#GO:0030835;macromolecule localization#GO:0033036;regulation of cellular component organization#GO:0051128;regulation of actin polymerization or depolymerization#GO:0008064;regulation of biological process#GO:0050789;regulation of cytoskeleton organization#GO:0051493;cellular component disassembly#GO:0022411;actin filament-based process#GO:0030029;regulation of protein-containing complex assembly#GO:0043254;regulation of biological quality#GO:0065008;regulation of cellular component biogenesis#GO:0044087;supramolecular fiber organization#GO:0097435;negative regulation of organelle organization#GO:0010639;negative regulation of protein-containing complex disassembly#GO:0043242;actin filament organization#GO:0007015;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;regulation of actin filament-based process#GO:0032970;barbed-end actin filament capping#GO:0051016;negative regulation of cellular component organization#GO:0051129;regulation of protein polymerization#GO:0032271;negative regulation of cellular process#GO:0048523;regulation of anatomical structure size#GO:0090066;protein-containing complex disassembly#GO:0032984;regulation of actin filament length#GO:0030832;regulation of organelle organization#GO:0033043;regulation of actin filament organization#GO:0110053;actin polymerization or depolymerization#GO:0008154;protein depolymerization#GO:0051261;regulation of protein-containing complex disassembly#GO:0043244;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of actin filament polymerization#GO:0030833;regulation of cellular component size#GO:0032535;protein localization#GO:0008104;actin filament depolymerization#GO:0030042;negative regulation of supramolecular fiber organization#GO:1902904;localization#GO:0051179;regulation of supramolecular fiber organization#GO:1902903;cellular component organization or biogenesis#GO:0071840;cellular macromolecule localization#GO:0070727;regulation of protein depolymerization#GO:1901879;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;maintenance of location#GO:0051235;regulation of actin filament depolymerization#GO:0030834;regulation of cellular process#GO:0050794;maintenance of location in cell#GO:0051651;negative regulation of actin filament polymerization#GO:0030837;biological regulation#GO:0065007;negative regulation of protein-containing complex assembly#GO:0031333;actin cytoskeleton organization#GO:0030036;negative regulation of cytoskeleton organization#GO:0051494 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;organelle#GO:0043226;actin filament#GO:0005884;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG174181|UniProtKB=T1F7R1 T1F7R1 20204860 PTHR31196:SF2 RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED HELRO|EnsemblGenome=HelroG165432|UniProtKB=T1EWS2 T1EWS2 20201022 PTHR31362:SF0 GLYCOSYLTRANSFERASE STELLO1-RELATED EXOSTOSIN DOMAIN-CONTAINING PROTEIN-RELATED glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG184689|UniProtKB=T1FLS1 T1FLS1 20209770 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG185098|UniProtKB=T1FME3 T1FME3 20209992 PTHR46002:SF5 EG:114D9.1 PROTEIN-RELATED EF-HAND DOMAIN-CONTAINING PROTEIN-RELATED regulation of sodium ion transmembrane transporter activity#GO:2000649;regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;regulation of sodium ion transport#GO:0002028;regulation of metal ion transport#GO:0010959;positive regulation of molecular function#GO:0044093;regulation of localization#GO:0032879;positive regulation of transport#GO:0051050;regulation of monoatomic cation transmembrane transport#GO:1904062;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of transporter activity#GO:0032411;regulation of transport#GO:0051049;regulation of cellular process#GO:0050794;regulation of molecular function#GO:0065009;biological regulation#GO:0065007;regulation of monoatomic ion transmembrane transporter activity#GO:0032412;regulation of transmembrane transporter activity#GO:0022898;regulation of monoatomic ion transport#GO:0043269;regulation of transporter activity#GO:0032409;positive regulation of biological process#GO:0048518 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG71060|UniProtKB=T1G0G2 T1G0G2 20214560 PTHR18952:SF141 CARBONIC ANHYDRASE CARBONIC ANHYDRASE carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG188638|UniProtKB=T1FQ74 T1FQ74 20210971 PTHR24020:SF84 COLLAGEN ALPHA VWFA DOMAIN-CONTAINING PROTEIN extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG154062|UniProtKB=T1ELD6 T1ELD6 20197386 PTHR24070:SF406 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY SMALL MONOMERIC GTPASE GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 small GTPase#PC00208;G-protein#PC00020 Integrin signalling pathway#P00034>Rap1#P00906 HELRO|EnsemblGenome=HelroG115315|UniProtKB=T1EG75 T1EG75 20195577 PTHR14102:SF11 PAR-6-RELATED LD29223P cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;microtubule cytoskeleton organization#GO:0000226;centrosome cycle#GO:0007098;cell cycle process#GO:0022402;cell cycle#GO:0007049;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule organizing center organization#GO:0031023 tight junction#PC00214 HELRO|EnsemblGenome=HelroG111430|UniProtKB=T1EFB3 T1EFB3 20195265 PTHR11808:SF15 TRANS-SULFURATION ENZYME FAMILY MEMBER CYSTATHIONINE GAMMA-LYASE small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;lyase activity#GO:0016829;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;sulfur compound metabolic process#GO:0006790;proteinogenic amino acid biosynthetic process#GO:0170038;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;alpha-amino acid biosynthetic process#GO:1901607;nitrogen compound metabolic process#GO:0006807;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;small molecule biosynthetic process#GO:0044283;L-amino acid biosynthetic process#GO:0170034;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 lyase#PC00144 Methionine biosynthesis#P02753>O-Succinyl homoserine lyase#P03026 HELRO|EnsemblGenome=HelroG114367|UniProtKB=T1EG10 T1EG10 20195512 PTHR23255:SF71 TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II RECEPTOR PROTEIN SERINE_THREONINE KINASE transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to endogenous stimulus#GO:0071495;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;response to growth factor#GO:0070848;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;response to stimulus#GO:0050896;response to endogenous stimulus#GO:0009719;cellular response to growth factor stimulus#GO:0071363;nitrogen compound metabolic process#GO:0006807;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 serine/threonine protein kinase receptor#PC00205 Wnt signaling pathway#P00057>TGFbetaactivated Kinase-1#P01442;Activin beta signaling pathway#P06210>BABO#P06231;ALP23B signaling pathway#P06209>BABO#P06220;MYO signaling pathway#P06215>BABO#P06310;TGF-beta signaling pathway#P00052>TGFbetareceptor I#P01278;TGF-beta signaling pathway#P00052>TGFbetareceptors#P01283;BMP/activin signaling pathway-drosophila#P06211>TGFbetaR I#P06241;TGF-beta signaling pathway#P00052>TGFbetareceptor II#P01277 HELRO|EnsemblGenome=HelroG78758|UniProtKB=T1G3F3 T1G3F3 20215601 PTHR43382:SF2 PROLYL-TRNA SYNTHETASE BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 Heme biosynthesis#P02746>Glutamyl-tRNA-synthetase#P02977 HELRO|EnsemblGenome=HelroG64313|UniProtKB=T1FXS6 T1FXS6 20213624 PTHR14744:SF15 N-ALPHA-ACETYLTRANSFERASE 60 N-ALPHA-ACETYLTRANSFERASE 60 histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;peptide alpha-N-acetyltransferase activity#GO:0004596;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;protein acylation#GO:0043543;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein acetylation#GO:0006473;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG111863|UniProtKB=T1EFF2 T1EFF2 20195304 PTHR24384:SF189 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG101408|UniProtKB=T1ED45 T1ED45 20194497 PTHR10527:SF1 IMPORTIN BETA IMPORTIN SUBUNIT BETA-1 signal sequence binding#GO:0005048;binding#GO:0005488;amide binding#GO:0033218;peptide binding#GO:0042277 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;protein import into nucleus#GO:0006606;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;protein localization to organelle#GO:0033365;intracellular transport#GO:0046907;nuclear transport#GO:0051169;import into nucleus#GO:0051170 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG67097|UniProtKB=T1FYW3 T1FYW3 20214011 PTHR22878:SF70 DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED DYNEIN HEAVY CHAIN 2, AXONEMAL HELRO|EnsemblGenome=HelroG137216|UniProtKB=T1EII3 T1EII3 20196383 PTHR24637:SF388 COLLAGEN NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180702|UniProtKB=T1FG68 T1FG68 20207817 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG184834|UniProtKB=T1FM23 T1FM23 20209872 PTHR16515:SF59 PR DOMAIN ZINC FINGER PROTEIN PR DOMAIN ZINC FINGER PROTEIN 1 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cell fate commitment#GO:0045165;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG194042|UniProtKB=T1FVL7 T1FVL7 20212863 PTHR16431:SF1 NEUROGENIC PROTEIN MASTERMIND NEUROGENIC PROTEIN MASTERMIND cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;cell cycle process#GO:0022402;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular process#GO:0009987;protein-DNA complex assembly#GO:0065004;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;chromosome organization#GO:0051276;organelle organization#GO:0006996;chromatin organization#GO:0006325;cell cycle#GO:0007049;chromatin remodeling#GO:0006338 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;chromosome#GO:0005694;chromatin#GO:0000785;membrane-bounded organelle#GO:0043227;chromosome, centromeric region#GO:0000775;chromosomal region#GO:0098687;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG173904|UniProtKB=T1F7C6 T1F7C6 20204725 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG79641|UniProtKB=T1G3R7 T1G3R7 20215715 PTHR21024:SF0 GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1 cellular respiration#GO:0045333;respiratory electron transport chain#GO:0022904;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;electron transport chain#GO:0022900;cellular process#GO:0009987;energy derivation by oxidation of organic compounds#GO:0015980;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG174205|UniProtKB=T1F7S4 T1F7S4 20204873 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170359|UniProtKB=T1F2Y8 T1F2Y8 20203187 PTHR13793:SF164 PHD FINGER PROTEINS ALHAMBRA, ISOFORM P nucleosome binding#GO:0031491;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;chromatin binding#GO:0003682;histone binding#GO:0042393 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG185640|UniProtKB=T1FN28 T1FN28 20210227 PTHR12688:SF0 DYNEIN LIGHT INTERMEDIATE CHAIN DYNEIN LIGHT INTERMEDIATE CHAIN protein binding#GO:0005515;binding#GO:0005488 cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;microtubule cytoskeleton organization#GO:0000226;microtubule-based movement#GO:0007018;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;microtubule organizing center#GO:0005815;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;microtubule cytoskeleton#GO:0015630;dynein complex#GO:0030286;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic dynein complex#GO:0005868;centrosome#GO:0005813;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Dynein complex#P00774 HELRO|EnsemblGenome=HelroG163460|UniProtKB=T1EU28 T1EU28 20200078 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174553|UniProtKB=T1F890 T1F890 20205039 PTHR15034:SF5 DEATH DOMAIN-CONTAINING PROTEIN CRADD DEATH DOMAIN-CONTAINING PROTEIN CRADD Wnt signaling pathway#P00057>Frizzled#P01428;Apoptosis signaling pathway#P00006>RAIDD#P00294;Cadherin signaling pathway#P00012>Frizzled#P00475;Alzheimer disease-presenilin pathway#P00004>Frizzled#P00119 HELRO|EnsemblGenome=HelroG63767|UniProtKB=T1FXK2 T1FXK2 20213550 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN SI:DKEY-17M8.2 HELRO|EnsemblGenome=HelroG115501|UniProtKB=T1EG87 T1EG87 20195589 PTHR11604:SF10 PROFILIN PROFILIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;actin binding#GO:0003779;binding#GO:0005488;actin monomer binding#GO:0003785 negative regulation of protein polymerization#GO:0032272;cellular localization#GO:0051641;negative regulation of biological process#GO:0048519;macromolecule localization#GO:0033036;regulation of cellular component organization#GO:0051128;regulation of actin polymerization or depolymerization#GO:0008064;regulation of biological process#GO:0050789;regulation of cytoskeleton organization#GO:0051493;regulation of protein-containing complex assembly#GO:0043254;regulation of biological quality#GO:0065008;regulation of cellular component biogenesis#GO:0044087;negative regulation of organelle organization#GO:0010639;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament-based process#GO:0032970;negative regulation of cellular component organization#GO:0051129;regulation of protein polymerization#GO:0032271;negative regulation of cellular process#GO:0048523;regulation of anatomical structure size#GO:0090066;regulation of actin filament length#GO:0030832;regulation of organelle organization#GO:0033043;regulation of actin filament organization#GO:0110053;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of actin filament polymerization#GO:0030833;regulation of cellular component size#GO:0032535;protein localization#GO:0008104;negative regulation of supramolecular fiber organization#GO:1902904;regulation of supramolecular fiber organization#GO:1902903;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;cellular macromolecule localization#GO:0070727;maintenance of location#GO:0051235;regulation of cellular process#GO:0050794;maintenance of location in cell#GO:0051651;negative regulation of actin filament polymerization#GO:0030837;biological regulation#GO:0065007;negative regulation of protein-containing complex assembly#GO:0031333;negative regulation of cytoskeleton organization#GO:0051494 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;cell cortex#GO:0005938;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG188057|UniProtKB=T1FPL1 T1FPL1 20210758 PTHR12053:SF3 PROTEASE FAMILY M28 PLASMA GLUTAMATE CARBOXYPEPTIDASE-RELATED CARBOXYPEPTIDASE Q metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG194798|UniProtKB=T1FWF3 T1FWF3 20213148 PTHR21426:SF12 EXOCYST COMPLEX COMPONENT 8 EXOCYST COMPLEX COMPONENT 8 localization#GO:0051179;localization within membrane#GO:0051668;cellular localization#GO:0051641;vesicle-mediated transport to the plasma membrane#GO:0098876;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;post-Golgi vesicle-mediated transport#GO:0006892;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;Golgi to plasma membrane transport#GO:0006893;protein localization#GO:0008104 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;vesicle tethering complex#GO:0099023;exocyst#GO:0000145;cell cortex#GO:0005938;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG169422|UniProtKB=T1F1X0 T1F1X0 20202820 PTHR10241:SF29 LETHAL 2 GIANT LARVAE PROTEIN LETHAL(2) GIANT LARVAE PROTEIN nucleoside-triphosphatase regulator activity#GO:0060589;cytoskeletal protein binding#GO:0008092;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;myosin binding#GO:0017022;GTPase activator activity#GO:0005096;molecular function regulator activity#GO:0098772;binding#GO:0005488;syntaxin binding#GO:0019905;protein binding#GO:0005515;enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;SNARE binding#GO:0000149 establishment or maintenance of cell polarity#GO:0007163;cellular localization#GO:0051641;organelle localization#GO:0051640;post-Golgi vesicle-mediated transport#GO:0006892;transport#GO:0006810;establishment of spindle orientation#GO:0051294;regulation of signaling#GO:0023051;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;regulation of Notch signaling pathway#GO:0008593;Golgi to plasma membrane transport#GO:0006893;regulation of biological process#GO:0050789;establishment of cell polarity#GO:0030010;actin filament-based process#GO:0030029;establishment of localization#GO:0051234;secretion#GO:0046903;regulation of signal transduction#GO:0009966;cytoskeleton organization#GO:0007010;establishment of organelle localization#GO:0051656;spindle localization#GO:0051653;secretion by cell#GO:0032940;localization within membrane#GO:0051668;regulation of cell communication#GO:0010646;vesicle-mediated transport to the plasma membrane#GO:0098876;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;establishment of spindle localization#GO:0051293;localization#GO:0051179;regulation of response to stimulus#GO:0048583;cellular component organization or biogenesis#GO:0071840;exocytosis#GO:0006887;microtubule-based process#GO:0007017;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;cortical cytoskeleton organization#GO:0030865;biological regulation#GO:0065007;cell cycle#GO:0007049;establishment of localization in cell#GO:0051649;actin cytoskeleton organization#GO:0030036;export from cell#GO:0140352;cortical actin cytoskeleton organization#GO:0030866 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;cytoskeleton#GO:0005856;cortical actin cytoskeleton#GO:0030864;cellular anatomical entity#GO:0110165;cell cortex#GO:0005938;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG76119|UniProtKB=T1G2F2 T1G2F2 20215250 PTHR10663:SF402 GUANYL-NUCLEOTIDE EXCHANGE FACTOR MIP16918P guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG104538|UniProtKB=T1EDM3 T1EDM3 20194675 PTHR19960:SF7 TEKTIN TEKTIN cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cilium or flagellum-dependent cell motility#GO:0001539;cell motility#GO:0048870;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;cilium movement involved in cell motility#GO:0060294;cilium movement#GO:0003341;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cilium-dependent cell motility#GO:0060285;microtubule-based process#GO:0007017;organelle organization#GO:0006996;plasma membrane bounded cell projection assembly#GO:0120031 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG119237|UniProtKB=T1EGM7 T1EGM7 20195727 PTHR11659:SF0 GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ligase#PC00142;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG105502|UniProtKB=T1EDV9 T1EDV9 20194761 PTHR12616:SF1 VACUOLAR PROTEIN SORTING VPS41 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG vesicle fusion#GO:0006906;cellular localization#GO:0051641;macroautophagy#GO:0016236;macromolecule localization#GO:0033036;protein targeting to vacuole#GO:0006623;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;nitrogen compound transport#GO:0071705;response to extracellular stimulus#GO:0009991;establishment of protein localization#GO:0045184;process utilizing autophagic mechanism#GO:0061919;organic substance transport#GO:0071702;cellular response to starvation#GO:0009267;establishment of localization#GO:0051234;catabolic process#GO:0009056;vesicle organization#GO:0016050;protein localization to organelle#GO:0033365;cellular response to extracellular stimulus#GO:0031668;organelle fusion#GO:0048284;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;establishment of protein localization to vacuole#GO:0072666;cellular response to stimulus#GO:0051716;vacuolar transport#GO:0007034;protein localization to vacuole#GO:0072665;protein targeting#GO:0006605;vesicle-mediated transport#GO:0016192;cellular metabolic process#GO:0044237;establishment of protein localization to organelle#GO:0072594;cell communication#GO:0007154;cellular component organization#GO:0016043;response to nutrient levels#GO:0031667;cellular process#GO:0009987;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;response to external stimulus#GO:0009605;response to stimulus#GO:0050896;cellular macromolecule localization#GO:0070727;response to stress#GO:0006950;membrane fusion#GO:0061025;organelle organization#GO:0006996;cellular response to nutrient levels#GO:0031669;response to starvation#GO:0042594;protein transport#GO:0015031;cellular response to external stimulus#GO:0071496;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;cellular response to stress#GO:0033554;autophagy#GO:0006914 membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;vesicle tethering complex#GO:0099023;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;late endosome#GO:0005770 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG81167|UniProtKB=T1G4A5 T1G4A5 20215903 PTHR11533:SF294 PROTEASE M1 ZINC METALLOPROTEASE THYROTROPIN-RELEASING HORMONE-DEGRADING ECTOENZYME metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;amide binding#GO:0033218;metal ion binding#GO:0046872;peptidase activity#GO:0008233;metalloaminopeptidase activity#GO:0070006;cation binding#GO:0043169;peptide binding#GO:0042277;hydrolase activity#GO:0016787;aminopeptidase activity#GO:0004177;exopeptidase activity#GO:0008238;ion binding#GO:0043167;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;peptide catabolic process#GO:0043171;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;membrane#GO:0016020;extracellular region#GO:0005576;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185153|UniProtKB=T1FMG3 T1FMG3 20210012 PTHR22811:SF210 TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN RE49489P endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;Golgi organization#GO:0007030;macromolecule localization#GO:0033036;transport#GO:0006810;endomembrane system organization#GO:0010256;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;organelle organization#GO:0006996;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;endoplasmic reticulum#GO:0005783;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG189337|UniProtKB=T1FQZ3 T1FQZ3 20211240 PTHR13058:SF19 THREE PRIME REPAIR EXONUCLEASE 1, 2 LD40940P hydrolase activity, acting on ester bonds#GO:0016788;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;3'-5'-DNA exonuclease activity#GO:0008296;nuclease activity#GO:0004518;DNA exonuclease activity#GO:0004529;catalytic activity#GO:0003824;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097;exonuclease activity#GO:0004527;3'-5' exonuclease activity#GO:0008408 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;heterocycle catabolic process#GO:0046700;macromolecule metabolic process#GO:0043170;DNA catabolic process#GO:0006308;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular nitrogen compound catabolic process#GO:0044270;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic cyclic compound catabolic process#GO:1901361;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;nucleobase-containing compound catabolic process#GO:0034655;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;cellular catabolic process#GO:0044248 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG186029|UniProtKB=T1FNK2 T1FNK2 20210399 PTHR23003:SF62 RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN SERINE_ARGININE (SR)-TYPE SHUTTLING MRNA BINDING PROTEIN NPL3 nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG178927|UniProtKB=T1FDW8 T1FDW8 20207017 PTHR24260:SF136 FAMILY NOT NAMED GH08193P-RELATED HELRO|EnsemblGenome=HelroG185908|UniProtKB=T1FNF5 T1FNF5 20210352 PTHR10334:SF498 CYSTEINE-RICH SECRETORY PROTEIN-RELATED MIP16674P defense/immunity protein#PC00090 PI3 kinase pathway#P00048>scl-1#G01545 HELRO|EnsemblGenome=HelroG170590|UniProtKB=T1F378 T1F378 20203277 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG83548|UniProtKB=T1G571 T1G571 20216219 PTHR47977:SF12 RAS-RELATED PROTEIN RAB RAS-RELATED PROTEIN RAB-44 GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;transport#GO:0006810 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG169437|UniProtKB=T1F1X8 T1F1X8 20202828 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175838|UniProtKB=T1F9R0 T1F9R0 20205559 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG185698|UniProtKB=T1FN59 T1FN59 20210257 PTHR22572:SF104 SUGAR-1-PHOSPHATE GUANYL TRANSFERASE MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE ALPHA transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 Mannose metabolism#P02752>Mannose 1-P guanylyl transferase#P03018 HELRO|EnsemblGenome=HelroG191378|UniProtKB=T1FSX8 T1FSX8 20211925 PTHR11046:SF25 OLIGORIBONUCLEASE, MITOCHONDRIAL SUBFAMILY NOT NAMED endoribonuclease#PC00094;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG181803|UniProtKB=T1FHC4 T1FHC4 20208223 PTHR13361:SF1 WW DOMAIN-BINDING PROTEIN 11 WW DOMAIN-BINDING PROTEIN 11 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG176722|UniProtKB=T1FAU0 T1FAU0 20205939 PTHR24406:SF8 TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED FI01110P-RELATED nucleic acid binding#GO:0003676;protein-containing complex binding#GO:0044877;chromatin DNA binding#GO:0031490;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG157737|UniProtKB=T1EMF0 T1EMF0 20197750 PTHR43294:SF21 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA CATION TRANSPORTING ATPASE primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG178171|UniProtKB=T1FCV8 T1FCV8 20206657 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG178807|UniProtKB=T1FDR6 T1FDR6 20206965 PTHR24351:SF201 RIBOSOMAL PROTEIN S6 KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG113553|UniProtKB=T1EFT5 T1EFT5 20195437 PTHR11927:SF9 GALACTOSIDE 2-L-FUCOSYLTRANSFERASE L-FUCOSYLTRANSFERASE transferase activity#GO:0016740;fucosyltransferase activity#GO:0008417;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein glycosylation#GO:0006486;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycosylation#GO:0070085;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG184819|UniProtKB=T1FM17 T1FM17 20209866 PTHR19315:SF9 ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4 ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein folding#GO:0006457;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane protein complex#GO:0098796;endoplasmic reticulum protein-containing complex#GO:0140534;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;EMC complex#GO:0072546;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG69335|UniProtKB=T1FZT3 T1FZT3 20214331 PTHR11753:SF2 ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY ADAPTOR PROTEIN COMPLEX AP-3 SMALL CHAIN SIGMA3 localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;cellular process#GO:0009987;transport#GO:0006810 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG69512|UniProtKB=T1FZW3 T1FZW3 20214361 PTHR46346:SF1 PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;phospholipid biosynthetic process#GO:0008654;macromolecule modification#GO:0043412;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycolipid metabolic process#GO:0006664;protein modification process#GO:0036211;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;glycerolipid biosynthetic process#GO:0045017;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;organic substance biosynthetic process#GO:1901576;liposaccharide metabolic process#GO:1903509;cellular process#GO:0009987;GPI anchor metabolic process#GO:0006505;membrane lipid biosynthetic process#GO:0046467;lipoprotein biosynthetic process#GO:0042158;primary metabolic process#GO:0044238;GPI anchor biosynthetic process#GO:0006506;carbohydrate derivative biosynthetic process#GO:1901137;membrane lipid metabolic process#GO:0006643;glycerophospholipid biosynthetic process#GO:0046474;glycolipid biosynthetic process#GO:0009247;organophosphate metabolic process#GO:0019637;lipoprotein metabolic process#GO:0042157;cellular lipid metabolic process#GO:0044255 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG129823|UniProtKB=T1EHS4 T1EHS4 20196124 PTHR24391:SF18 HISTONE H4 TRANSCRIPTION FACTOR-RELATED EG:115C2.6 PROTEIN C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG108181|UniProtKB=T1EEG4 T1EEG4 20194966 PTHR45711:SF6 CHLORIDE CHANNEL PROTEIN CHLORIDE CHANNEL PROTEIN voltage-gated monoatomic ion channel activity#GO:0005244;inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG134536|UniProtKB=T1EI52 T1EI52 20196252 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG88371|UniProtKB=T1G718 T1G718 20216865 PTHR10801:SF0 24-DEHYDROCHOLESTEROL REDUCTASE DELTA(24)-STEROL REDUCTASE reductase#PC00198;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG107165|UniProtKB=T1EE83 T1EE83 20194885 PTHR12706:SF30 STRAWBERRY NOTCH-RELATED PROTEIN STRAWBERRY NOTCH-RELATED HELRO|EnsemblGenome=HelroG73647|UniProtKB=T1G1G8 T1G1G8 20214916 PTHR13232:SF10 NAD(P)H-HYDRATE EPIMERASE NAD(P)H-HYDRATE EPIMERASE epimerase/racemase#PC00096;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG160015|UniProtKB=T1EPN8 T1EPN8 20198538 PTHR16021:SF22 MANSC DOMAIN CONTAINING PROTEIN 1 OXIDANT-INDUCED CELL-CYCLE ARREST PROTEIN 5 HELRO|EnsemblGenome=HelroG157064|UniProtKB=T1EM58 T1EM58 20197658 PTHR12128:SF66 DIHYDRODIPICOLINATE SYNTHASE 4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;catalytic activity#GO:0003824;hydro-lyase activity#GO:0016836 lyase#PC00144 Lysine biosynthesis#P02751>Dihydrodipicolinate synthase#P03008 HELRO|EnsemblGenome=HelroG74374|UniProtKB=T1G1Q3 T1G1Q3 20215001 PTHR12052:SF5 THIOREDOXIN-LIKE PROTEN 4A, 4B THIOREDOXIN-LIKE PROTEIN 4A nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;U4/U6 x U5 tri-snRNP complex#GO:0046540;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;U5 snRNP#GO:0005682;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;protein-containing complex#GO:0032991;small nuclear ribonucleoprotein complex#GO:0030532;spliceosomal tri-snRNP complex#GO:0097526;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG193068|UniProtKB=T1FUL3 T1FUL3 20212509 PTHR43377:SF2 BILIVERDIN REDUCTASE A BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00560)-RELATED dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG145534|UniProtKB=T1EJK8 T1EJK8 20196758 PTHR24393:SF138 ZINC FINGER PROTEIN IP01201P-RELATED DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG186187|UniProtKB=T1FNS3 T1FNS3 20210470 PTHR45841:SF1 MRNA TURNOVER PROTEIN 4 MRTO4 MRNA TURNOVER PROTEIN 4 HOMOLOG RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;negative regulation of cellular metabolic process#GO:0031324;cellular component biogenesis#GO:0044085;negative regulation of biological process#GO:0048519;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;ribosomal large subunit biogenesis#GO:0042273;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;regulation of biological process#GO:0050789;ncRNA metabolic process#GO:0034660;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;mRNA catabolic process#GO:0006402;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;ribosome biogenesis#GO:0042254;regulation of macromolecule biosynthetic process#GO:0010556;organic substance catabolic process#GO:1901575;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;macromolecule biosynthetic process#GO:0009059;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;negative regulation of metabolic process#GO:0009892;nuclear-transcribed mRNA catabolic process#GO:0000956;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;regulation of cellular biosynthetic process#GO:0031326;aromatic compound catabolic process#GO:0019439;regulation of macromolecule metabolic process#GO:0060255;rRNA metabolic process#GO:0016072;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;ribonucleoprotein complex biogenesis#GO:0022613;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;preribosome, large subunit precursor#GO:0030687;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;preribosome#GO:0030684 HELRO|EnsemblGenome=HelroG184828|UniProtKB=T1FM22 T1FM22 20209871 PTHR10814:SF21 TRANSDUCIN-LIKE ENHANCER PROTEIN PROTEIN GROUCHO molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;protein-macromolecule adaptor activity#GO:0030674 regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;negative regulation of response to stimulus#GO:0048585;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;regulation of Wnt signaling pathway#GO:0030111;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of cellular process#GO:0048523;negative regulation of cell communication#GO:0010648 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transcription cofactor#PC00217 Wnt signaling pathway#P00057>Transducin-like Enhance of Split 1-3#P01436 HELRO|EnsemblGenome=HelroG116521|UniProtKB=T1EGF5 T1EGF5 20195657 PTHR22957:SF497 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN ECOTROPIC VIRAL INTEGRATION SITE 5 ORTHOLOG nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;activation of GTPase activity#GO:0090630;biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG160213|UniProtKB=T1EPZ6 T1EPZ6 20198646 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG190925|UniProtKB=T1FSF3 T1FSF3 20211750 PTHR22883:SF475 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC23 palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular localization#GO:0051641;macromolecule localization#GO:0033036;macromolecule modification#GO:0043412;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;protein palmitoylation#GO:0018345;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;localization within membrane#GO:0051668;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein localization to membrane#GO:0072657;organonitrogen compound biosynthetic process#GO:1901566;protein targeting#GO:0006605;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;protein acylation#GO:0043543;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipoprotein biosynthetic process#GO:0042158;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;lipoprotein metabolic process#GO:0042157 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185404|UniProtKB=T1FMR8 T1FMR8 20210117 PTHR16356:SF1 TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 6 TMCO6 TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 6 HELRO|EnsemblGenome=HelroG170018|UniProtKB=T1F2J4 T1F2J4 20203044 PTHR10177:SF344 CYCLINS G1_S-SPECIFIC CYCLIN-E protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234 regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;mitotic cell cycle phase transition#GO:0044772;regulation of nitrogen compound metabolic process#GO:0051171;cell cycle G1/S phase transition#GO:0044843;cell cycle process#GO:0022402;positive regulation of cell cycle#GO:0045787;positive regulation of cell cycle G1/S phase transition#GO:1902808;regulation of catalytic activity#GO:0050790;mitotic cell cycle process#GO:1903047;G1/S transition of mitotic cell cycle#GO:0000082;regulation of phosphorus metabolic process#GO:0051174;regulation of biological process#GO:0050789;mitotic cell cycle#GO:0000278;regulation of molecular function#GO:0065009;positive regulation of cell cycle process#GO:0090068;positive regulation of mitotic cell cycle#GO:0045931;regulation of protein serine/threonine kinase activity#GO:0071900;regulation of G1/S transition of mitotic cell cycle#GO:2000045;positive regulation of biological process#GO:0048518;regulation of cyclin-dependent protein serine/threonine kinase activity#GO:0000079;regulation of kinase activity#GO:0043549;regulation of protein kinase activity#GO:0045859;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of cell cycle phase transition#GO:1901987;cellular process#GO:0009987;cell cycle phase transition#GO:0044770;regulation of cell cycle process#GO:0010564;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule metabolic process#GO:0060255;regulation of protein phosphorylation#GO:0001932;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of phosphorylation#GO:0042325;regulation of mitotic cell cycle#GO:0007346;regulation of transferase activity#GO:0051338;regulation of cell cycle G1/S phase transition#GO:1902806;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 microtubule organizing center#GO:0005815;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;centrosome#GO:0005813;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856 kinase activator#PC00138 Cell cycle#P00013>CdkC#P00489;p53 pathway#P00059>Cyclin E#P04610;p53 pathway feedback loops 2#P04398>cyclin E#P04664;Cell cycle#P00013>Cyclin E#P00483 HELRO|EnsemblGenome=HelroG182099|UniProtKB=T1FHR0 T1FHR0 20208359 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167520|UniProtKB=T1EZG2 T1EZG2 20201962 PTHR34487:SF1 ACYL-ACP THIOESTERASE ACYL-ACP THIOESTERASE HELRO|EnsemblGenome=HelroG184107|UniProtKB=T1FKL3 T1FKL3 20209362 PTHR23202:SF124 WASP INTERACTING PROTEIN-RELATED C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG190605|UniProtKB=T1FS45 T1FS45 20211642 PTHR12062:SF9 N-ACETYLGLUCOSAMINYLTRANSFERASE VI ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE A, ISOFORM A acetylglucosaminyltransferase activity#GO:0008375;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi apparatus subcompartment#GO:0098791;cellular anatomical entity#GO:0110165;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;Golgi stack#GO:0005795;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG169246|UniProtKB=T1F1M5 T1F1M5 20202725 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194556|UniProtKB=T1FW70 T1FW70 20213066 PTHR48057:SF7 LEUCINE-RICH REPEAT SERINE/THREONINE-PROTEIN KINASE 1 LEUCINE-RICH REPEAT SERINE_THREONINE-PROTEIN KINASE 1 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG80455|UniProtKB=T1G410 T1G410 20215808 PTHR12984:SF16 SCY1-RELATED S/T PROTEIN KINASE-LIKE BLACK MATCH, ISOFORM H non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG186090|UniProtKB=T1FNN2 T1FNN2 20210429 PTHR45633:SF3 60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL 60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG172159|UniProtKB=T1F532 T1F532 20203931 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG114357|UniProtKB=T1EG09 T1EG09 20195511 PTHR43272:SF107 LONG-CHAIN-FATTY-ACID--COA LIGASE LONG-CHAIN-FATTY-ACID--COA LIGASE 5 long-chain fatty acid-CoA ligase activity#GO:0004467;ligase activity#GO:0016874;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG190092|UniProtKB=T1FRP2 T1FRP2 20211489 PTHR11766:SF0 TYROSYL-TRNA SYNTHETASE TYROSINE--TRNA LIGASE, MITOCHONDRIAL catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 aminoacyl-tRNA synthetase#PC00047 HELRO|EnsemblGenome=HelroG108880|UniProtKB=T1EEN3 T1EEN3 20195035 PTHR12670:SF1 CERAMIDASE NEUTRAL CERAMIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;alcohol biosynthetic process#GO:0046165;organonitrogen compound catabolic process#GO:1901565;organic hydroxy compound biosynthetic process#GO:1901617;lipid catabolic process#GO:0016042;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;sphingolipid metabolic process#GO:0006665;carboxylic acid biosynthetic process#GO:0046394;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;sphingolipid catabolic process#GO:0030149;cellular lipid catabolic process#GO:0044242;amide metabolic process#GO:0043603;sphingolipid biosynthetic process#GO:0030148;fatty acid biosynthetic process#GO:0006633;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;long-chain fatty acid metabolic process#GO:0001676;organic hydroxy compound metabolic process#GO:1901615;organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;monocarboxylic acid biosynthetic process#GO:0072330;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;alcohol metabolic process#GO:0006066;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;membrane lipid biosynthetic process#GO:0046467;monocarboxylic acid metabolic process#GO:0032787;ceramide metabolic process#GO:0006672;primary metabolic process#GO:0044238;fatty acid metabolic process#GO:0006631;membrane lipid metabolic process#GO:0006643;small molecule biosynthetic process#GO:0044283;cellular lipid metabolic process#GO:0044255;carboxylic acid metabolic process#GO:0019752;small molecule metabolic process#GO:0044281 cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 HELRO|EnsemblGenome=HelroG119222|UniProtKB=T1EGM6 T1EGM6 20195726 PTHR24416:SF566 TYROSINE-PROTEIN KINASE RECEPTOR EPIDERMAL GROWTH FACTOR RECEPTOR signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 negative regulation of biological process#GO:0048519;signal transduction#GO:0007165;neurogenesis#GO:0022008;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;positive regulation of cell population proliferation#GO:0008284;regulation of catalytic activity#GO:0050790;nervous system development#GO:0007399;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;system development#GO:0048731;cell differentiation#GO:0030154;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;negative regulation of programmed cell death#GO:0043069;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;regulation of programmed cell death#GO:0043067;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;cellular developmental process#GO:0048869;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;regulation of apoptotic process#GO:0042981;regulation of cell population proliferation#GO:0042127;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;negative regulation of apoptotic process#GO:0043066;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;anatomical structure development#GO:0048856;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 basal plasma membrane#GO:0009925;receptor complex#GO:0043235;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;basal part of cell#GO:0045178;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 EGF receptor signaling pathway#P00018>EGFR#P00542;Cadherin signaling pathway#P00012>EGFR#P00466 HELRO|EnsemblGenome=HelroG190944|UniProtKB=T1FSG1 T1FSG1 20211758 PTHR38537:SF8 JITTERBUG, ISOFORM N FILAMIN-A HELRO|EnsemblGenome=HelroG173331|UniProtKB=T1F6P4 T1F6P4 20204493 PTHR22198:SF1 FERM DOMAIN-CONTAINING PROTEIN FERM DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170722|UniProtKB=T1F3D0 T1F3D0 20203329 PTHR46513:SF13 VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG188910|UniProtKB=T1FQG9 T1FQG9 20211066 PTHR11841:SF1 REELIN REELIN extracellular matrix glycoprotein#PC00100;extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG152392|UniProtKB=T1EKR2 T1EKR2 20197162 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185461|UniProtKB=T1FMU6 T1FMU6 20210145 PTHR24056:SF254 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 2 transferase activity#GO:0016740;cyclin-dependent protein kinase activity#GO:0097472;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein serine/threonine kinase activity#GO:0004674;protein binding#GO:0005515;cyclin binding#GO:0030332;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 signal transduction#GO:0007165;mitotic cell cycle phase transition#GO:0044772;macromolecule modification#GO:0043412;cell cycle G1/S phase transition#GO:0044843;cell cycle process#GO:0022402;protein modification process#GO:0036211;mitotic cell cycle process#GO:1903047;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;G1/S transition of mitotic cell cycle#GO:0000082;regulation of biological process#GO:0050789;mitotic cell cycle#GO:0000278;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;phosphorylation#GO:0016310;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;regulation of cell cycle G2/M phase transition#GO:1902749;regulation of mitotic cell cycle phase transition#GO:1901990;macromolecule metabolic process#GO:0043170;regulation of cell cycle phase transition#GO:1901987;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;cell cycle phase transition#GO:0044770;primary metabolic process#GO:0044238;regulation of cell cycle process#GO:0010564;response to stimulus#GO:0050896;regulation of cellular biosynthetic process#GO:0031326;response to chemical#GO:0042221;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of G2/M transition of mitotic cell cycle#GO:0010389;regulation of mitotic cell cycle#GO:0007346;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695 non-receptor serine/threonine protein kinase#PC00167 EGF receptor signaling pathway#P00018>ERK1-2#P00543;p53 pathway#P00059>Cdc2#P04634;p53 pathway feedback loops 2#P04398>cdk2#P04653;p53 pathway#P00059>Cdk2#P04625 HELRO|EnsemblGenome=HelroG186227|UniProtKB=T1FNU4 T1FNU4 20210491 PTHR12302:SF2 EBNA2 BINDING PROTEIN P100 STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1 hydrolase activity, acting on ester bonds#GO:0016788;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;nuclease activity#GO:0004518;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;mRNA catabolic process#GO:0006402;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;organic substance catabolic process#GO:1901575;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG181486|UniProtKB=T1FH20 T1FH20 20208119 PTHR14049:SF9 LEPRECAN 1 PROCOLLAGEN-PROLINE 3-DIOXYGENASE extracellular matrix glycoprotein#PC00100 HELRO|EnsemblGenome=HelroG69639|UniProtKB=T1FZX6 T1FZX6 20214374 PTHR10217:SF548 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL GH12235P monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG79910|UniProtKB=T1G3V1 T1G3V1 20215749 PTHR44117:SF1 INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG kinesin binding#GO:0019894;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;binding#GO:0005488 non-motile cilium assembly#GO:1905515;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;cilium assembly#GO:0060271;cell projection organization#GO:0030030;transport#GO:0006810;microtubule-based movement#GO:0007018;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;transport along microtubule#GO:0010970;cell projection assembly#GO:0030031;intraciliary transport#GO:0042073;localization#GO:0051179;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based transport#GO:0099111;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;organelle organization#GO:0006996;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;plasma membrane bounded cell projection assembly#GO:0120031;protein-containing complex localization#GO:0031503 microtubule organizing center#GO:0005815;non-motile cilium#GO:0097730;ciliary base#GO:0097546;cellular anatomical entity#GO:0110165;centriole#GO:0005814;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG108915|UniProtKB=T1EEN7 T1EEN7 20195039 PTHR47978:SF21 FAMILY NOT NAMED RAS-RELATED PROTEIN RAB-26 GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;anion binding#GO:0043168;ion binding#GO:0043167 regulation of biological process#GO:0050789;regulation of transport#GO:0051049;regulation of secretion#GO:0051046;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of localization#GO:0032879;regulation of secretion by cell#GO:1903530;regulation of vesicle-mediated transport#GO:0060627;regulation of exocytosis#GO:0017157 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG190415|UniProtKB=T1FRZ2 T1FRZ2 20211589 PTHR19211:SF15 ATP-BINDING TRANSPORT PROTEIN-RELATED ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2 nucleotide binding#GO:0000166;carbohydrate derivative binding#GO:0097367;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168;ATP binding#GO:0005524 translation elongation factor#PC00222;translational protein#PC00263 HELRO|EnsemblGenome=HelroG161970|UniProtKB=T1ES38 T1ES38 20199388 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG102536|UniProtKB=T1EDA2 T1EDA2 20194554 PTHR21727:SF0 PHOSPHORYLATED CTD INTERACTING FACTOR 1 MRNA (2'-O-METHYLADENOSINE-N(6)-)-METHYLTRANSFERASE HELRO|EnsemblGenome=HelroG103833|UniProtKB=T1EDH7 T1EDH7 20194629 PTHR45670:SF13 E3 UBIQUITIN-PROTEIN LIGASE TRIP12 E3 UBIQUITIN-PROTEIN LIGASE TRIP12 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;nuclear speck#GO:0016607;organelle#GO:0043226;nuclear body#GO:0016604;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG67414|UniProtKB=T1FZ04 T1FZ04 20214052 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG124128|UniProtKB=T1EH02 T1EH02 20195852 PTHR12159:SF9 G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity, acting on DNA#GO:0140097;DNA N-glycosylase activity#GO:0019104;catalytic activity#GO:0003824 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;base-excision repair#GO:0006284;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;DNA damage response#GO:0006974;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 DNA glycosylase#PC00010 HELRO|EnsemblGenome=HelroG190578|UniProtKB=T1FS41 T1FS41 20211638 PTHR12231:SF253 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG173431|UniProtKB=T1F6T6 T1F6T6 20204535 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG175454|UniProtKB=T1F998 T1F998 20205397 PTHR10891:SF918 EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN CALCIUM-BINDING PROTEIN 2 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG101399|UniProtKB=T1ED44 T1ED44 20194496 PTHR31596:SF1 T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG162367|UniProtKB=T1ESK6 T1ESK6 20199556 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG115456|UniProtKB=T1EG83 T1EG83 20195585 PTHR45876:SF8 FI04035P FI04035P nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;GTPase regulator activity#GO:0030695;molecular function activator activity#GO:0140677;GTPase activator activity#GO:0005096;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185886|UniProtKB=T1FNE4 T1FNE4 20210341 PTHR10264:SF127 BAND 7 PROTEIN-RELATED PODOCIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG76381|UniProtKB=T1G2J4 T1G2J4 20215292 PTHR18834:SF2 STEROID RECEPTOR RNA ACTIVATOR 1 STEROID RECEPTOR RNA ACTIVATOR 1 transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;molecular adaptor activity#GO:0060090;transcription regulator activity#GO:0140110;nuclear receptor coactivator activity#GO:0030374;protein-macromolecule adaptor activity#GO:0030674 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG189738|UniProtKB=T1FRB6 T1FRB6 20211363 PTHR10816:SF19 MYELIN TRANSCRIPTION FACTOR 1-RELATED PROTEIN INTERACTING WITH TTK69 AND SIN3A, ISOFORM D molecular adaptor activity#GO:0060090;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714;protein-macromolecule adaptor activity#GO:0030674 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG177965|UniProtKB=T1FCJ1 T1FCJ1 20206540 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG83575|UniProtKB=T1G574 T1G574 20216222 PTHR12634:SF8 SIT4 YEAST -ASSOCIATING PROTEIN-RELATED FIERY MOUNTAIN, ISOFORM D phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888 regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;regulation of nitrogen compound metabolic process#GO:0051171;regulation of phosphatase activity#GO:0010921;regulation of dephosphorylation#GO:0035303;regulation of catalytic activity#GO:0050790;regulation of phosphorus metabolic process#GO:0051174;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of molecular function#GO:0065009;biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336;regulation of phosphoprotein phosphatase activity#GO:0043666;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG174108|UniProtKB=T1F7M2 T1F7M2 20204821 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG160941|UniProtKB=T1EQW0 T1EQW0 20198960 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG74545|UniProtKB=T1G1S5 T1G1S5 20215023 PTHR12645:SF0 ALR/ERV FAD-LINKED SULFHYDRYL OXIDASE ALR nucleotide binding#GO:0000166;protein-disulfide reductase activity#GO:0015035;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;flavin adenine dinucleotide binding#GO:0050660;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;disulfide oxidoreductase activity#GO:0015036;ion binding#GO:0043167;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxidase#PC00175;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG184885|UniProtKB=T1FM48 T1FM48 20209897 PTHR11571:SF224 GLUTATHIONE S-TRANSFERASE HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE glutathione transferase activity#GO:0004364;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824 sulfur compound metabolic process#GO:0006790;nitrogen compound metabolic process#GO:0006807;peptide metabolic process#GO:0006518;cellular modified amino acid metabolic process#GO:0006575;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular process#GO:0009987;glutathione metabolic process#GO:0006749;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG157853|UniProtKB=T1EMG8 T1EMG8 20197768 PTHR11006:SF124 PROTEIN ARGININE N-METHYLTRANSFERASE ARGININE METHYLTRANSFERASE 1-RELATED N-methyltransferase activity#GO:0008170;histone modifying activity#GO:0140993;transferase activity#GO:0016740;catalytic activity#GO:0003824;histone methyltransferase activity#GO:0042054;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a protein#GO:0140096;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein methyltransferase activity#GO:0008276 protein-DNA complex organization#GO:0071824;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;cellular component organization#GO:0016043;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;methylation#GO:0032259;macromolecule methylation#GO:0043414;nitrogen compound metabolic process#GO:0006807;protein-containing complex organization#GO:0043933;chromatin organization#GO:0006325;protein metabolic process#GO:0019538;chromatin remodeling#GO:0006338;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG193941|UniProtKB=T1FVI1 T1FVI1 20212827 PTHR12280:SF20 PANTOTHENATE KINASE 4'-PHOSPHOPANTETHEINE PHOSPHATASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 kinase#PC00137 Coenzyme A biosynthesis#P02736>Pantothenate kinase#P02885 HELRO|EnsemblGenome=HelroG145634|UniProtKB=T1EJL4 T1EJL4 20196764 PTHR11945:SF534 MADS BOX PROTEIN MYOCYTE-SPECIFIC ENHANCER FACTOR 2 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 MADS box transcription factor#PC00250 p38 MAPK pathway#P05918>MEF#P06023;Oxidative stress response#P00046>MEF-2#P01128 HELRO|EnsemblGenome=HelroG157040|UniProtKB=T1EM52 T1EM52 20197652 PTHR47981:SF1 RAB FAMILY RE17845P lysosome organization#GO:0007040;vesicle fusion#GO:0006906;endosomal transport#GO:0016197;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;membrane organization#GO:0061024;phagocytosis#GO:0006909;organelle membrane fusion#GO:0090174;transport#GO:0006810;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147;localization#GO:0051179;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;vacuole organization#GO:0007033;membrane fusion#GO:0061025;establishment of localization#GO:0051234;organelle organization#GO:0006996;phagolysosome assembly#GO:0001845;establishment of localization in cell#GO:0051649;vesicle organization#GO:0016050;intracellular transport#GO:0046907;lytic vacuole organization#GO:0080171;import into cell#GO:0098657;organelle fusion#GO:0048284 endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vacuole#GO:0005773;cellular anatomical entity#GO:0110165;organelle#GO:0043226;lytic vacuole#GO:0000323;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;lysosome#GO:0005764;endomembrane system#GO:0012505;phagocytic vesicle#GO:0045335;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;late endosome#GO:0005770 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG120098|UniProtKB=T1EGP5 T1EGP5 20195745 PTHR45689:SF5 I[[H]] CHANNEL, ISOFORM E I[[H]] CHANNEL, ISOFORM E monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;sodium ion transport#GO:0006814;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;regulation of membrane depolarization#GO:0003254;sodium ion transmembrane transport#GO:0035725;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG107851|UniProtKB=T1EED3 T1EED3 20194935 PTHR13182:SF8 ZINC FINGER PROTEIN 622 CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622 cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;cellular process#GO:0009987;ribonucleoprotein complex biogenesis#GO:0022613 ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;protein-containing complex#GO:0032991;preribosome, large subunit precursor#GO:0030687 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG183816|UniProtKB=T1FK86 T1FK86 20209235 PTHR23004:SF23 DOUBLECORTIN DOMAIN CONTAINING 2 DOUBLECORTIN DOMAIN-CONTAINING PROTEIN supramolecular complex#GO:0099080;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG192949|UniProtKB=T1FUG1 T1FUG1 20212457 PTHR22897:SF8 QUIESCIN Q6-RELATED SULFHYDRYL OXIDASE SULFHYDRYL OXIDASE protein-disulfide reductase activity#GO:0015035;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824;protein disulfide isomerase activity#GO:0003756;disulfide oxidoreductase activity#GO:0015036;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein folding#GO:0006457;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;extracellular region#GO:0005576;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxidase#PC00175;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG181954|UniProtKB=T1FHI3 T1FHI3 20208282 PTHR13720:SF33 WD-40 REPEAT PROTEIN HELP DOMAIN-CONTAINING PROTEIN cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG159958|UniProtKB=T1EPL6 T1EPL6 20198516 PTHR46600:SF1 THAP DOMAIN-CONTAINING THAP DOMAIN-CONTAINING PROTEIN 1 zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG189554|UniProtKB=T1FR53 T1FR53 20211300 PTHR10649:SF12 ARYL HYDROCARBON RECEPTOR SPINELESS, ISOFORM C sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;molecular transducer activity#GO:0060089;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG181208|UniProtKB=T1FGQ8 T1FGQ8 20208007 PTHR24404:SF106 ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG64886|UniProtKB=T1FY07 T1FY07 20213705 PTHR10410:SF3 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT H nucleic acid binding#GO:0003676;translation regulator activity#GO:0045182;metallopeptidase activity#GO:0008237;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;translation initiation factor activity#GO:0003743;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;translation regulator activity, nucleic acid binding#GO:0090079;translation factor activity, RNA binding#GO:0008135 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;translational initiation#GO:0006413;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;eukaryotic translation initiation factor 3 complex#GO:0005852;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG81900|UniProtKB=T1G4K4 T1G4K4 20216002 PTHR24057:SF0 GLYCOGEN SYNTHASE KINASE-3 ALPHA PROTEIN KINASE SHAGGY-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;developmental process#GO:0032502;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cell differentiation#GO:0030154;peptidyl-threonine phosphorylation#GO:0018107;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Glycogen Synthase Kinase-3Beta#P01441;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>GSK-3#P00902;PI3 kinase pathway#P00048>GSK3#P01181;Interleukin signaling pathway#P00036>GSK3#P00976;Ras Pathway#P04393>GSK3#P04546;Angiogenesis#P00005>GSK3beta#P00211;Alzheimer disease-presenilin pathway#P00004>GSK-3beta#P00175;PDGF signaling pathway#P00047>GSK3#P01153 HELRO|EnsemblGenome=HelroG78292|UniProtKB=T1G3A3 T1G3A3 20215551 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-LIKE 1 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;localization#GO:0051179;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 membrane protein complex#GO:0098796;synapse#GO:0045202;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron projection#GO:0043005;transmembrane transporter complex#GO:1902495;cell projection#GO:0042995;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HELRO|EnsemblGenome=HelroG85555|UniProtKB=T1G5Z1 T1G5Z1 20216488 PTHR23074:SF86 AAA DOMAIN-CONTAINING SPASTIN pyrophosphatase activity#GO:0016462;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG181252|UniProtKB=T1FGS9 T1FGS9 20208028 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175786|UniProtKB=T1F9N7 T1F9N7 20205536 PTHR10642:SF26 RIBONUCLEASE H1 RIBONUCLEASE H1 catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular nitrogen compound catabolic process#GO:0044270;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic cyclic compound catabolic process#GO:1901361;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;organic substance catabolic process#GO:1901575;nucleobase-containing compound catabolic process#GO:0034655;DNA replication#GO:0006260;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;cellular catabolic process#GO:0044248 endoribonuclease#PC00094;RNA metabolism protein#PC00031 DNA replication#P00017>RNase H#P00538 HELRO|EnsemblGenome=HelroG66944|UniProtKB=T1FYT6 T1FYT6 20213984 PTHR11473:SF15 AROMATIC AMINO ACID HYDROXYLASE TYROSINE 3-MONOOXYGENASE oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497 cytoplasm#GO:0005737;somatodendritic compartment#GO:0036477;cell body#GO:0044297;neuron projection#GO:0043005;neuronal cell body#GO:0043025;perikaryon#GO:0043204;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;axon#GO:0030424;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176 Dopamine receptor mediated signaling pathway#P05912>TH#P05970;Adrenaline and noradrenaline biosynthesis#P00001>TH#P00062 HELRO|EnsemblGenome=HelroG177541|UniProtKB=T1FBU9 T1FBU9 20206298 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190040|UniProtKB=T1FRM2 T1FRM2 20211469 PTHR47958:SF24 ATP-DEPENDENT RNA HELICASE DBP3 RNA HELICASE catalytic activity, acting on RNA#GO:0140098;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640;mRNA binding#GO:0003729 membrane-enclosed lumen#GO:0031974;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG103893|UniProtKB=T1EDI2 T1EDI2 20194634 PTHR10283:SF82 SOLUTE CARRIER FAMILY 13 MEMBER SOLUTE CARRIER FAMILY 13 MEMBER 2 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG193399|UniProtKB=T1FUY4 T1FUY4 20212630 PTHR11360:SF251 MONOCARBOXYLATE TRANSPORTER MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN transporter#PC00227 HELRO|EnsemblGenome=HelroG75117|UniProtKB=T1G211 T1G211 20215109 PTHR47980:SF24 LD44762P IP08727P-RELATED GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;protein secretion#GO:0009306;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;establishment of protein localization to extracellular region#GO:0035592;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;protein transport#GO:0015031;protein localization to extracellular region#GO:0071692;export from cell#GO:0140352;secretion by cell#GO:0032940 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG183126|UniProtKB=T1FJ61 T1FJ61 20208860 PTHR45818:SF3 PROTEIN VAV PROTEIN VAV nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;regulation of GTPase activity#GO:0043087;regulation of molecular function#GO:0065009 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 PDGF signaling pathway#P00047>Vav#P01169 HELRO|EnsemblGenome=HelroG92061|UniProtKB=T1G8B8 T1G8B8 20217315 PTHR14969:SF13 SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE AT30094P metabolite interconversion enzyme#PC00262;hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG67113|UniProtKB=T1FYW6 T1FYW6 20214014 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG143038|UniProtKB=T1EJ88 T1EJ88 20196638 PTHR24006:SF758 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36 cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG184326|UniProtKB=T1FL02 T1FL02 20209501 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG162988|UniProtKB=T1ETI0 T1ETI0 20199880 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED BRCT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170451|UniProtKB=T1F329 T1F329 20203228 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183857|UniProtKB=T1FK99 T1FK99 20209248 PTHR31742:SF1 RPA-INTERACTING PROTEIN RPAIN RPA-INTERACTING PROTEIN cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;protein import into nucleus#GO:0006606;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365;nuclear transport#GO:0051169;import into nucleus#GO:0051170 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG85342|UniProtKB=T1G5V5 T1G5V5 20216452 PTHR12726:SF0 CERAMIDE GLUCOSYLTRANSFERASE CERAMIDE GLUCOSYLTRANSFERASE UDP-glucosyltransferase activity#GO:0035251;glucosyltransferase activity#GO:0046527;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;glycosphingolipid biosynthetic process#GO:0006688;glycolipid metabolic process#GO:0006664;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;liposaccharide metabolic process#GO:1903509;membrane lipid biosynthetic process#GO:0046467;sphingolipid metabolic process#GO:0006665;primary metabolic process#GO:0044238;ceramide metabolic process#GO:0006672;amide biosynthetic process#GO:0043604;carbohydrate derivative biosynthetic process#GO:1901137;membrane lipid metabolic process#GO:0006643;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;ceramide biosynthetic process#GO:0046513;glycolipid biosynthetic process#GO:0009247;cellular lipid metabolic process#GO:0044255;amide metabolic process#GO:0043603;sphingolipid biosynthetic process#GO:0030148;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;membrane#GO:0016020 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG191159|UniProtKB=T1FSN9 T1FSN9 20211836 PTHR22826:SF106 RHO GUANINE EXCHANGE FACTOR-RELATED TRIO, ISOFORM A nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;extrinsic component of membrane#GO:0019898 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG108261|UniProtKB=T1EEH7 T1EEH7 20194979 PTHR11647:SF1 HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER COLLAPSIN RESPONSE MEDIATOR PROTEIN metabolite interconversion enzyme#PC00262;hydrolase#PC00121 Axon guidance mediated by semaphorins#P00007>CRMP#P00339;Pyrimidine Metabolism#P02771>Dihydropyrimidinase#P03125 HELRO|EnsemblGenome=HelroG193435|UniProtKB=T1FUZ4 T1FUZ4 20212640 PTHR13165:SF0 ARSENITE-RESISTANCE PROTEIN 2 SERRATE RNA EFFECTOR MOLECULE HOMOLOG negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;RNA metabolic process#GO:0016070;regulatory ncRNA processing#GO:0070918;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;regulatory ncRNA-mediated gene silencing#GO:0031047;miRNA processing#GO:0035196;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary miRNA processing#GO:0031053;primary metabolic process#GO:0044238;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear body#GO:0016604;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG82886|UniProtKB=T1G4X9 T1G4X9 20216127 PTHR13172:SF5 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG71946|UniProtKB=T1G0T3 T1G0T3 20214681 PTHR24067:SF157 UBIQUITIN-CONJUGATING ENZYME E2 FI11905P ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG108526|UniProtKB=T1EEJ8 T1EEJ8 20195000 PTHR47958:SF11 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE DDX4-RELATED catalytic activity, acting on RNA#GO:0140098;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640;mRNA binding#GO:0003729 germ cell development#GO:0007281;cellular developmental process#GO:0048869;gamete generation#GO:0007276;cellular process involved in reproduction in multicellular organism#GO:0022412;multicellular organism reproduction#GO:0032504;developmental process#GO:0032502;cellular process#GO:0009987;cell development#GO:0048468;developmental process involved in reproduction#GO:0003006;cell differentiation#GO:0030154;reproduction#GO:0000003;anatomical structure development#GO:0048856;sexual reproduction#GO:0019953;reproductive process#GO:0022414;multicellular organismal process#GO:0032501;multicellular organismal reproductive process#GO:0048609 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;P granule#GO:0043186;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG161529|UniProtKB=T1ERL4 T1ERL4 20199214 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG68641|UniProtKB=T1FZH5 T1FZH5 20214223 PTHR42825:SF7 AMINO ACID AMINOTRANSFERASE BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE transaminase activity#GO:0008483;transferase activity#GO:0016740;catalytic activity#GO:0003824 transaminase#PC00216;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG167127|UniProtKB=T1EZ20 T1EZ20 20201820 PTHR43721:SF2 ELONGATION FACTOR TU-RELATED ELONGATION FACTOR TU, MITOCHONDRIAL nucleic acid binding#GO:0003676;translation regulator activity#GO:0045182;translation regulator activity, nucleic acid binding#GO:0090079;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation elongation factor activity#GO:0003746;translation factor activity, RNA binding#GO:0008135 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;mitochondrial gene expression#GO:0140053;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;mitochondrial translation#GO:0032543;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;translational elongation#GO:0006414;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 translation elongation factor#PC00222;translational protein#PC00263 HELRO|EnsemblGenome=HelroG161726|UniProtKB=T1ERU3 T1ERU3 20199293 PTHR14787:SF1 C10ORF188 FAMILY MEMBER ATPASE PAAT HELRO|EnsemblGenome=HelroG164470|UniProtKB=T1EVG6 T1EVG6 20200566 PTHR37487:SF3 CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE CLEAVAGE_POLYADENYLATION SPECIFICITY FACTOR A SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG155295|UniProtKB=T1ELH8 T1ELH8 20197428 PTHR23117:SF13 GUANYLATE KINASE-RELATED GUANYLATE KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, phosphate group as acceptor#GO:0016776;catalytic activity#GO:0003824;kinase activity#GO:0016301 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 transferase#PC00220;kinase#PC00137;metabolite interconversion enzyme#PC00262 De novo purine biosynthesis#P02738>Guanylate kinase#P02904 HELRO|EnsemblGenome=HelroG181853|UniProtKB=T1FHE4 T1FHE4 20208243 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG172592|UniProtKB=T1F5K6 T1F5K6 20204105 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG65544|UniProtKB=T1FY93 T1FY93 20213791 PTHR12874:SF29 F-BOX ONLY PROTEIN 48-RELATED F-BOX ONLY PROTEIN 9 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 SCF ubiquitin ligase complex#GO:0019005;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG170948|UniProtKB=T1F3M3 T1F3M3 20203422 PTHR12458:SF8 ORF PROTEIN CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20 regulation of microtubule-based process#GO:0032886;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;regulation of cell motility#GO:2000145;regulation of locomotion#GO:0040012;positive regulation of locomotion#GO:0040017;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;regulation of biological quality#GO:0065008;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;positive regulation of cell motility#GO:2000147;biological regulation#GO:0065007;plasma membrane bounded cell projection assembly#GO:0120031;positive regulation of biological process#GO:0048518 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;motile cilium#GO:0031514;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;cilium#GO:0005929;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 Transcription regulation by bZIP transcription factor#P00055>TFIIB#P01397;General transcription regulation#P00023>TFIIB#P00668 HELRO|EnsemblGenome=HelroG71703|UniProtKB=T1G0Q3 T1G0Q3 20214651 PTHR24347:SF393 SERINE/THREONINE-PROTEIN KINASE SPAGHETTI-SQUASH ACTIVATOR, ISOFORM C transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>MLCK#P00877;Cytoskeletal regulation by Rho GTPase#P00016>MLCK#P00514 HELRO|EnsemblGenome=HelroG189030|UniProtKB=T1FQK8 T1FQK8 20211105 PTHR24356:SF414 SERINE/THREONINE-PROTEIN KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG174284|UniProtKB=T1F7X8 T1F7X8 20204927 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185976|UniProtKB=T1FNI2 T1FNI2 20210379 PTHR16950:SF25 ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4 ZINC TRANSPORTER SLC39A7 inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075 inorganic ion homeostasis#GO:0098771;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;inorganic ion transmembrane transport#GO:0098660;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation transport#GO:0006812;transition metal ion transport#GO:0000041;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG63585|UniProtKB=T1FXH7 T1FXH7 20213525 PTHR31489:SF2 LIN52 FAMILY MEMBER PROTEIN LIN-52 HOMOLOG HELRO|EnsemblGenome=HelroG157726|UniProtKB=T1EME7 T1EME7 20197747 PTHR48112:SF32 HIGH MOBILITY GROUP PROTEIN DSP1 HIGH MOBILITY GROUP PROTEIN B3 HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG192214|UniProtKB=T1FTP8 T1FTP8 20212195 PTHR15346:SF0 DYNACTIN SUBUNIT DYNACTIN SUBUNIT 2 cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;mitotic spindle organization#GO:0007052;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;cell cycle#GO:0007049;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;spindle organization#GO:0007051;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;microtubule cytoskeleton#GO:0015630;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG187018|UniProtKB=T1FP57 T1FP57 20210604 PTHR11679:SF30 VESICLE PROTEIN SORTING-ASSOCIATED PROTEIN ROP syntaxin binding#GO:0019905;protein binding#GO:0005515;binding#GO:0005488;SNARE binding#GO:0000149 cellular localization#GO:0051641;organelle localization#GO:0051640;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;exocytic process#GO:0140029;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;export from cell#GO:0140352;secretion by cell#GO:0032940 intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;secretory granule#GO:0030141;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;secretory vesicle#GO:0099503;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG114577|UniProtKB=T1EG32 T1EG32 20195534 PTHR35250:SF1 SMALL INTEGRAL MEMBRANE PROTEIN 4 UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 5 HELRO|EnsemblGenome=HelroG66928|UniProtKB=T1FYT4 T1FYT4 20213982 PTHR24055:SF79 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE 15 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Integrin signalling pathway#P00034>ERK#P00907;EGF receptor signaling pathway#P00018>ERK1-2#P00543;Ras Pathway#P04393>ERK#P04542;Interleukin signaling pathway#P00036>ERK#P00965;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>MAPK#P00835;PDGF signaling pathway#P00047>ERK#P01143;FGF signaling pathway#P00021>ERK1-2#P00627;Interferon-gamma signaling pathway#P00035>Serine kinase#P00955;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;Toll receptor signaling pathway#P00054>ERK1#P01358;Apoptosis signaling pathway#P00006>MAPK#P00269;TGF-beta signaling pathway#P00052>p42/p44MAPKs#P01293;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>ERK#P00889;Parkinson disease#P00049>ERK#P01211;Endothelin signaling pathway#P00019>ERK#P00566 HELRO|EnsemblGenome=HelroG171190|UniProtKB=T1F3X0 T1F3X0 20203519 PTHR44755:SF8 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide hormone binding#GO:0017046;hormone binding#GO:0042562;binding#GO:0005488;peptide binding#GO:0042277;amide binding#GO:0033218 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG81066|UniProtKB=T1G484 T1G484 20215882 PTHR10263:SF5 V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT V-TYPE PROTON ATPASE 16 KDA PROTEOLIPID SUBUNIT C cellular anatomical entity#GO:0110165;membrane#GO:0016020 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG167528|UniProtKB=T1EZG5 T1EZG5 20201965 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG83677|UniProtKB=T1G590 T1G590 20216237 PTHR42985:SF2 SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER SODIUM-DEPENDENT MULTIVITAMIN TRANSPORTER symporter activity#GO:0015293;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;monoatomic cation transport#GO:0006812;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG183196|UniProtKB=T1FJA3 T1FJA3 20208902 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG108777|UniProtKB=T1EEM3 T1EEM3 20195025 PTHR11006:SF10 PROTEIN ARGININE N-METHYLTRANSFERASE HISTONE-ARGININE METHYLTRANSFERASE CARMER-RELATED N-methyltransferase activity#GO:0008170;histone modifying activity#GO:0140993;transferase activity#GO:0016740;catalytic activity#GO:0003824;histone methyltransferase activity#GO:0042054;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a protein#GO:0140096;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein methyltransferase activity#GO:0008276 protein-DNA complex organization#GO:0071824;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular component organization#GO:0016043;peptidyl-amino acid modification#GO:0018193;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;methylation#GO:0032259;macromolecule methylation#GO:0043414;nitrogen compound metabolic process#GO:0006807;protein-containing complex organization#GO:0043933;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG193608|UniProtKB=T1FV64 T1FV64 20212710 PTHR15600:SF42 SACSIN SACSIN heat shock protein binding#GO:0031072;protein binding#GO:0005515;protein-folding chaperone binding#GO:0051087;binding#GO:0005488;Hsp70 protein binding#GO:0030544 HELRO|EnsemblGenome=HelroG161993|UniProtKB=T1ES47 T1ES47 20199397 PTHR34090:SF1 39S RIBOSOMAL PROTEIN L52, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN ML52 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrial large ribosomal subunit#GO:0005762;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;organellar ribosome#GO:0000313;protein-containing complex#GO:0032991;large ribosomal subunit#GO:0015934;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840;mitochondrial protein-containing complex#GO:0098798 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG185474|UniProtKB=T1FMV2 T1FMV2 20210151 PTHR11835:SF34 DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 organic hydroxy compound metabolic process#GO:1901615;oxoacid metabolic process#GO:0043436;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;alcohol metabolic process#GO:0006066;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;energy derivation by oxidation of organic compounds#GO:0015980;tricarboxylic acid cycle#GO:0006099;primary metabolic process#GO:0044238;secondary alcohol metabolic process#GO:1902652;carboxylic acid metabolic process#GO:0019752;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 dehydrogenase#PC00092;oxidoreductase#PC00176 Leucine biosynthesis#P02749>3-Isopropylmalate dehydrogenase#P03001 HELRO|EnsemblGenome=HelroG84610|UniProtKB=T1G5K8 T1G5K8 20216355 PTHR23426:SF76 FERREDOXIN/ADRENODOXIN ADRENODOXIN-LIKE PROTEIN 2, MITOCHONDRIAL cellular metabolic process#GO:0044237;electron transport chain#GO:0022900;cellular process#GO:0009987;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176 Vitamin D metabolism and pathway#P04396>FDX#P04607 HELRO|EnsemblGenome=HelroG74952|UniProtKB=T1G1Y5 T1G1Y5 20215083 PTHR24064:SF577 SOLUTE CARRIER FAMILY 22 MEMBER GH09241P secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG76586|UniProtKB=T1G2L7 T1G2L7 20215315 PTHR24409:SF409 ZINC FINGER PROTEIN 142 C2H2-TYPE DOMAIN-CONTAINING PROTEIN C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG64965|UniProtKB=T1FY21 T1FY21 20213719 PTHR18966:SF422 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED signaling receptor activity#GO:0038023;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;ligand-gated channel activity#GO:0022834 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019 HELRO|EnsemblGenome=HelroG191659|UniProtKB=T1FT68 T1FT68 20212015 PTHR12228:SF0 TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;RNA metabolic process#GO:0016070;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;RNA polymerase II preinitiation complex assembly#GO:0051123;transcription initiation at RNA polymerase II promoter#GO:0006367;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;DNA-directed RNA polymerase complex#GO:0000428;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nucleoplasm#GO:0005654;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;transcription factor TFIID complex#GO:0005669;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;transcription regulator complex#GO:0005667;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 general transcription factor#PC00259 General transcription regulation#P00023>TBP-associated factors#P00658;Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385 HELRO|EnsemblGenome=HelroG194058|UniProtKB=T1FVM6 T1FVM6 20212872 PTHR24006:SF915 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE-RELATED cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 protein modification by small protein conjugation or removal#GO:0070647;mitotic cell cycle phase transition#GO:0044772;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;cell cycle G1/S phase transition#GO:0044843;cell cycle process#GO:0022402;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular process#GO:0009987;post-translational protein modification#GO:0043687;mitotic cell cycle process#GO:1903047;cell cycle phase transition#GO:0044770;primary metabolic process#GO:0044238;G1/S transition of mitotic cell cycle#GO:0000082;mitotic cell cycle#GO:0000278;nitrogen compound metabolic process#GO:0006807;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;cell cycle#GO:0007049;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG188055|UniProtKB=T1FPL0 T1FPL0 20210757 PTHR10574:SF435 NETRIN/LAMININ-RELATED LAMININ SUBUNIT GAMMA-1 neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;cell projection organization#GO:0030030;animal organ development#GO:0048513;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;axonogenesis#GO:0007409;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization#GO:0016043;cell morphogenesis#GO:0000902;cellular process#GO:0009987;tissue development#GO:0009888;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure development#GO:0048856;animal organ morphogenesis#GO:0009887;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Laminin#P00947 HELRO|EnsemblGenome=HelroG73772|UniProtKB=T1G1I2 T1G1I2 20214930 PTHR23086:SF101 PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE LP03320P-RELATED transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301;lipid kinase activity#GO:0001727 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 kinase#PC00137 HELRO|EnsemblGenome=HelroG116093|UniProtKB=T1EGC9 T1EGC9 20195631 PTHR11827:SF103 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium ion transmembrane transporter activity#GO:0015079;sodium ion transmembrane transporter activity#GO:0015081;symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;chloride transmembrane transporter activity#GO:0015108;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 inorganic ion homeostasis#GO:0098771;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;sodium ion homeostasis#GO:0055078;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;inorganic anion transmembrane transport#GO:0098661;import across plasma membrane#GO:0098739;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;inorganic anion transport#GO:0015698;potassium ion transport#GO:0006813;regulation of anatomical structure size#GO:0090066;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;monoatomic anion transmembrane transport#GO:0098656;chloride transport#GO:0006821;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;cellular component organization#GO:0016043;cellular process#GO:0009987;chemical homeostasis#GO:0048878;regulation of cellular component size#GO:0032535;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;sodium ion transport#GO:0006814;regulation of cell size#GO:0008361;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;sodium ion transmembrane transport#GO:0035725;potassium ion import across plasma membrane#GO:1990573 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG176995|UniProtKB=T1FB40 T1FB40 20206039 PTHR12394:SF12 ZYGIN LD08195P cytoplasm#GO:0005737;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;neuron projection#GO:0043005;intracellular anatomical structure#GO:0005622;axon#GO:0030424 HELRO|EnsemblGenome=HelroG163385|UniProtKB=T1ETZ5 T1ETZ5 20200045 PTHR19297:SF181 GLYCOSYLTRANSFERASE 14 FAMILY MEMBER PROTEIN XYLOSYLTRANSFERASE acetylglucosaminyltransferase activity#GO:0008375;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG87707|UniProtKB=T1G6U6 T1G6U6 20216793 PTHR23248:SF63 PHOSPHOLIPID SCRAMBLASE-RELATED PHOSPHOLIPID SCRAMBLASE phospholipid transporter activity#GO:0005548;transporter activity#GO:0005215;lipid transporter activity#GO:0005319 organophosphate ester transport#GO:0015748;macromolecule localization#GO:0033036;membrane organization#GO:0061024;plasma membrane organization#GO:0007009;transport#GO:0006810;plasma membrane phospholipid scrambling#GO:0017121;endomembrane system organization#GO:0010256;cellular component organization#GO:0016043;regulation of membrane lipid distribution#GO:0097035;phospholipid transport#GO:0015914;cellular process#GO:0009987;lipid transport#GO:0006869;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;biological regulation#GO:0065007;lipid translocation#GO:0034204;lipid localization#GO:0010876;phospholipid translocation#GO:0045332 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG75112|UniProtKB=T1G209 T1G209 20215107 PTHR12482:SF5 LIPASE ROG1-RELATED-RELATED DUF676 DOMAIN-CONTAINING PROTEIN lipid metabolic process#GO:0006629;cellular metabolic process#GO:0044237;cellular process#GO:0009987;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG184211|UniProtKB=T1FKR9 T1FKR9 20209418 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG67484|UniProtKB=T1FZ14 T1FZ14 20214062 PTHR24082:SF473 NUCLEAR HORMONE RECEPTOR ECDYSONE-INDUCED PROTEIN 75B, ISOFORM B cis-regulatory region sequence-specific DNA binding#GO:0000987;signaling receptor activity#GO:0038023;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;signal transduction#GO:0007165;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of RNA metabolic process#GO:0051253;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;hormone-mediated signaling pathway#GO:0009755;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;positive regulation of biosynthetic process#GO:0009891;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of transcription by RNA polymerase II#GO:0000122;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;response to organic substance#GO:0010033;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;cellular response to endogenous stimulus#GO:0071495;negative regulation of biosynthetic process#GO:0009890;cellular response to chemical stimulus#GO:0070887;regulation of DNA-templated transcription#GO:0006355;cellular response to organic substance#GO:0071310;negative regulation of metabolic process#GO:0009892;cell communication#GO:0007154;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;negative regulation of nitrogen compound metabolic process#GO:0051172;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;negative regulation of macromolecule biosynthetic process#GO:0010558;response to hormone#GO:0009725;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;response to chemical#GO:0042221;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG73133|UniProtKB=T1G1A6 T1G1A6 20214854 PTHR18952:SF208 CARBONIC ANHYDRASE CARBONIC ANHYDRASE XA-RELATED carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 cellular metabolic process#GO:0044237;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG79055|UniProtKB=T1G3J6 T1G3J6 20215644 PTHR42985:SF40 SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER LD47995P-RELATED symporter activity#GO:0015293;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;monoatomic cation transport#GO:0006812;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG189348|UniProtKB=T1FQZ7 T1FQZ7 20211244 PTHR36191:SF1 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159908|UniProtKB=T1EPJ6 T1EPJ6 20198496 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG171864|UniProtKB=T1F4S4 T1F4S4 20203823 PTHR10527:SF5 IMPORTIN BETA IMPORTIN 5 signal sequence binding#GO:0005048;binding#GO:0005488;amide binding#GO:0033218;peptide binding#GO:0042277 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;protein import into nucleus#GO:0006606;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;protein localization to organelle#GO:0033365;intracellular transport#GO:0046907;nuclear transport#GO:0051169;import into nucleus#GO:0051170 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG86941|UniProtKB=T1G6J5 T1G6J5 20216692 PTHR10217:SF548 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL GH12235P monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG177747|UniProtKB=T1FC66 T1FC66 20206415 PTHR23309:SF49 3-HYDROXYACYL-COA DEHYROGENASE PEROXISOMAL BIFUNCTIONAL ENZYME oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;lipid oxidation#GO:0034440;cellular metabolic process#GO:0044237;lipid catabolic process#GO:0016042;lipid modification#GO:0030258;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;fatty acid catabolic process#GO:0009062;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;fatty acid metabolic process#GO:0006631;small molecule catabolic process#GO:0044282;fatty acid beta-oxidation#GO:0006635;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;carboxylic acid metabolic process#GO:0019752;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG91458|UniProtKB=T1G840 T1G840 20217237 PTHR11188:SF17 ARRESTIN DOMAIN CONTAINING PROTEIN FI21816P1 localization#GO:0051179;organic substance transport#GO:0071702;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;protein transport#GO:0015031;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG184119|UniProtKB=T1FKM2 T1FKM2 20209371 PTHR42264:SF3 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN F-BOX DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG176192|UniProtKB=T1FAA3 T1FAA3 20205752 PTHR24353:SF153 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;cytosol#GO:0005829;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Enkephalin release#P05913>PKA#P05972;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Endothelin signaling pathway#P00019>PKA#P00570;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059 HELRO|EnsemblGenome=HelroG165085|UniProtKB=T1EW98 T1EW98 20200848 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG89851|UniProtKB=T1G7I3 T1G7I3 20217030 PTHR13533:SF1 N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG191038|UniProtKB=T1FSJ0 T1FSJ0 20211787 PTHR15141:SF76 TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3 TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG159297|UniProtKB=T1ENU8 T1ENU8 20198248 PTHR11552:SF147 GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE CHOLINE DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG150697|UniProtKB=T1EKG9 T1EKG9 20197069 PTHR23308:SF36 NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1 SMAD NUCLEAR-INTERACTING PROTEIN 1 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147 TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282 HELRO|EnsemblGenome=HelroG175932|UniProtKB=T1F9X3 T1F9X3 20205622 PTHR22748:SF6 AP ENDONUCLEASE DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE hydrolase activity, acting on ester bonds#GO:0016788;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;3'-5'-DNA exonuclease activity#GO:0008296;nuclease activity#GO:0004518;DNA exonuclease activity#GO:0004529;catalytic activity#GO:0003824;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097;phosphoric diester hydrolase activity#GO:0008081;exonuclease activity#GO:0004527;3'-5' exonuclease activity#GO:0008408;phosphoric ester hydrolase activity#GO:0042578 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;base-excision repair#GO:0006284;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 HELRO|EnsemblGenome=HelroG103917|UniProtKB=T1EDI4 T1EDI4 20194636 PTHR19376:SF37 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;RNA polymerase activity#GO:0097747;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;RNA polymerase II activity#GO:0001055 membrane-enclosed lumen#GO:0031974;RNA polymerase II, core complex#GO:0005665;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase II, holoenzyme#GO:0016591;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG181415|UniProtKB=T1FGZ3 T1FGZ3 20208092 PTHR45011:SF1 DAP3-BINDING CELL DEATH ENHANCER 1 DAP3-BINDING CELL DEATH ENHANCER 1 HELRO|EnsemblGenome=HelroG191961|UniProtKB=T1FTG4 T1FTG4 20212111 PTHR10742:SF416 FLAVIN MONOAMINE OXIDASE SPERMINE OXIDASE oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 oxidase#PC00175;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG194499|UniProtKB=T1FW46 T1FW46 20213042 PTHR15898:SF18 BIFUNCTIONAL APOPTOSIS REGULATOR GLUCOSE-INDUCED DEGRADATION PROTEIN 4 HOMOLOG transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG131725|UniProtKB=T1EHW4 T1EHW4 20196164 PTHR24056:SF400 CELL DIVISION PROTEIN KINASE KINASE, PUTATIVE-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG158430|UniProtKB=T1EMS2 T1EMS2 20197872 PTHR45848:SF4 DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;dephosphorylation#GO:0016311;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein phosphatase#PC00195;protein modifying enzyme#PC00260 Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG81096|UniProtKB=T1G490 T1G490 20215888 PTHR12504:SF0 MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG187911|UniProtKB=T1FPG8 T1FPG8 20210715 PTHR22809:SF11 METHYLTRANSFERASE-RELATED TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2 methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG194881|UniProtKB=T1FWJ0 T1FWJ0 20213185 PTHR45784:SF5 C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED HELRO|EnsemblGenome=HelroG190561|UniProtKB=T1FS33 T1FS33 20211630 PTHR45920:SF4 FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;cortical cytoskeleton organization#GO:0030865;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;cortical actin cytoskeleton organization#GO:0030866 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG132900|UniProtKB=T1EHZ9 T1EHZ9 20196199 PTHR24416:SF550 TYROSINE-PROTEIN KINASE RECEPTOR FIBROBLAST GROWTH FACTOR RECEPTOR HOMOLOG 1-RELATED signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG166804|UniProtKB=T1EYJ8 T1EYJ8 20201648 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158755|UniProtKB=T1EN77 T1EN77 20198027 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193301|UniProtKB=T1FUV0 T1FUV0 20212596 PTHR12394:SF12 ZYGIN LD08195P cytoplasm#GO:0005737;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;neuron projection#GO:0043005;intracellular anatomical structure#GO:0005622;axon#GO:0030424 HELRO|EnsemblGenome=HelroG189040|UniProtKB=T1FQL0 T1FQL0 20211107 PTHR24356:SF163 SERINE/THREONINE-PROTEIN KINASE 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PDK1#P00831;Ras Pathway#P04393>PDK#P04555;CCKR signaling map#P06959>PDPK1#P07162;PI3 kinase pathway#P00048>PDK1 ACT#P01190;PI3 kinase pathway#P00048>PDK1#P01196;p53 pathway feedback loops 2#P04398>PDK1/2#P04656;p53 pathway#P00059>PDK1/2#P04616;Interleukin signaling pathway#P00036>PDK1/2#P00985;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PDK1/2#P00903;PDGF signaling pathway#P00047>PDK1/2#P01164;PI3 kinase pathway#P00048>P110ACT#P01177 HELRO|EnsemblGenome=HelroG195048|UniProtKB=T1FWP9 T1FWP9 20213244 PTHR13017:SF0 5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE-RELATED METHENYLTETRAHYDROFOLATE SYNTHASE DOMAIN-CONTAINING PROTEIN cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ligase#PC00142 HELRO|EnsemblGenome=HelroG179440|UniProtKB=T1FEP9 T1FEP9 20207298 PTHR10075:SF100 BASIGIN RELATED FASCICLIN-2 cell adhesion molecule binding#GO:0050839;cell-cell adhesion mediator activity#GO:0098632;protein binding#GO:0005515;binding#GO:0005488 neuron projection guidance#GO:0097485;cell recognition#GO:0008037;neurogenesis#GO:0022008;cell projection organization#GO:0030030;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;axonogenesis#GO:0007409;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156;cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cell morphogenesis#GO:0000902;cellular process#GO:0009987;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure development#GO:0048856;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;axon#GO:0030424 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG92373|UniProtKB=T1G8F3 T1G8F3 20217350 PTHR10367:SF17 MRNA-CAPPING ENZYME MRNA-CAPPING ENZYME catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mRNA processing#GO:0006397;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 RNA processing factor#PC00147;RNA metabolism protein#PC00031;mRNA capping factor#PC00145 HELRO|EnsemblGenome=HelroG185298|UniProtKB=T1FMM6 T1FMM6 20210075 PTHR20426:SF0 RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG 18S RRNA AMINOCARBOXYPROPYLTRANSFERASE HELRO|EnsemblGenome=HelroG169022|UniProtKB=T1F197 T1F197 20202597 PTHR31855:SF2 GUANINE NUCLEOTIDE EXCHANGE C9ORF72 GUANINE NUCLEOTIDE EXCHANGE FACTOR C9ORF72 HELRO|EnsemblGenome=HelroG171434|UniProtKB=T1F499 T1F499 20203648 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG83069|UniProtKB=T1G500 T1G500 20216148 PTHR10687:SF2 SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN localization#GO:0051179;organic substance transport#GO:0071702;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;protein transport#GO:0015031;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 bounding membrane of organelle#GO:0098588;trans-Golgi network#GO:0005802;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;trans-Golgi network membrane#GO:0032588;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;recycling endosome membrane#GO:0055038;organelle#GO:0043226;endosome membrane#GO:0010008;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;recycling endosome#GO:0055037;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791;cytoplasmic vesicle membrane#GO:0030659 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG162928|UniProtKB=T1ETD2 T1ETD2 20199832 PTHR17039:SF0 U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10 U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10 membrane-enclosed lumen#GO:0031974;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513;90S preribosome#GO:0030686 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG172808|UniProtKB=T1F5Y6 T1F5Y6 20204236 PTHR10484:SF207 HISTONE H4 HISTONE H4 nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;nucleosome organization#GO:0034728;nucleosome assembly#GO:0006334;protein-containing complex organization#GO:0043933;protein-containing complex assembly#GO:0065003;chromatin organization#GO:0006325;cellular component organization#GO:0016043;cellular process#GO:0009987;chromatin remodeling#GO:0006338;protein-DNA complex assembly#GO:0065004 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG158082|UniProtKB=T1EMJ2 T1EMJ2 20197792 PTHR10889:SF3 DEOXYRIBOSE-PHOSPHATE ALDOLASE DEOXYRIBOSE-PHOSPHATE ALDOLASE lyase activity#GO:0016829;carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;heterocycle catabolic process#GO:0046700;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;cellular nitrogen compound catabolic process#GO:0044270;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;carbohydrate catabolic process#GO:0016052;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carbohydrate metabolic process#GO:0005975;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248;heterocycle metabolic process#GO:0046483;nucleoside phosphate catabolic process#GO:1901292;carbohydrate derivative catabolic process#GO:1901136;cellular metabolic process#GO:0044237;nucleotide catabolic process#GO:0009166;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organophosphate catabolic process#GO:0046434;primary metabolic process#GO:0044238;aromatic compound catabolic process#GO:0019439;organic cyclic compound catabolic process#GO:1901361;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;nucleotide metabolic process#GO:0009117;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 aldolase#PC00044;lyase#PC00144 HELRO|EnsemblGenome=HelroG75979|UniProtKB=T1G2D4 T1G2D4 20215232 PTHR45723:SF2 SERINE/THREONINE-PROTEIN KINASE RIO1 SERINE_THREONINE-PROTEIN KINASE RIO1 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG91243|UniProtKB=T1G816 T1G816 20217213 PTHR10322:SF23 DNA POLYMERASE CATALYTIC SUBUNIT DNA POLYMERASE DELTA CATALYTIC SUBUNIT DNA metabolism protein#PC00009 DNA replication#P00017>Pol delta#P00533 HELRO|EnsemblGenome=HelroG98406|UniProtKB=T1G9M4 T1G9M4 20217770 PTHR11692:SF0 BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;purine ribonucleoside monophosphate metabolic process#GO:0009167;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;nucleotide biosynthetic process#GO:0009165;nucleoside monophosphate metabolic process#GO:0009123;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;IMP metabolic process#GO:0046040;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;purine nucleoside monophosphate metabolic process#GO:0009126;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribonucleoside monophosphate metabolic process#GO:0009161;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;IMP biosynthetic process#GO:0006188;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 De novo purine biosynthesis#P02738>AICAR transformylase#P02900;De novo purine biosynthesis#P02738>IMP cyclohydrolase#P02894 HELRO|EnsemblGenome=HelroG83905|UniProtKB=T1G5B5 T1G5B5 20216262 PTHR11671:SF1 V-TYPE ATP SYNTHASE SUBUNIT D V-TYPE PROTON ATPASE SUBUNIT D ATPase complex#GO:1904949;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;cellular anatomical entity#GO:0110165;membrane#GO:0016020;proton-transporting two-sector ATPase complex#GO:0016469;catalytic complex#GO:1902494 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG191207|UniProtKB=T1FSQ8 T1FSQ8 20211855 PTHR24139:SF34 CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;phospholipase A2 activity#GO:0004623;fatty acyl-CoA hydrolase activity#GO:0047617;catalytic activity#GO:0003824;thiolester hydrolase activity#GO:0016790;hydrolase activity#GO:0016787;phospholipase activity#GO:0004620 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of lipid metabolic process#GO:0019216;regulation of lipid biosynthetic process#GO:0046890;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 phospholipase#PC00186 Gonadotropin-releasing hormone receptor pathway#P06664>PLA2#P06738 HELRO|EnsemblGenome=HelroG185306|UniProtKB=T1FMN1 T1FMN1 20210080 PTHR46513:SF13 VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG171484|UniProtKB=T1F4C5 T1F4C5 20203674 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG177750|UniProtKB=T1FC69 T1FC69 20206418 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG176657|UniProtKB=T1FAR9 T1FAR9 20205918 PTHR10383:SF9 SERINE INCORPORATOR SERINE INCORPORATOR, ISOFORM F cellular anatomical entity#GO:0110165;membrane#GO:0016020 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG177154|UniProtKB=T1FBA3 T1FBA3 20206102 PTHR46232:SF1 SMARCE1 REGULATOR OF CHROMATIN SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1 nucleosome binding#GO:0031491;nucleic acid binding#GO:0003676;chromatin DNA binding#GO:0031490;nuclear receptor binding#GO:0016922;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;transcription factor binding#GO:0008134;DNA-binding transcription factor binding#GO:0140297 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;ATPase complex#GO:1904949;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;SWI/SNF complex#GO:0016514;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG188635|UniProtKB=T1FQ72 T1FQ72 20210969 PTHR19432:SF37 SUGAR TRANSPORTER SOLUTE CARRIER FAMILY 45 MEMBER 3 solute:proton symporter activity#GO:0015295;inorganic molecular entity transmembrane transporter activity#GO:0015318;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078;carbohydrate transmembrane transporter activity#GO:0015144;active monoatomic ion transmembrane transporter activity#GO:0022853;symporter activity#GO:0015293;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 cellular anatomical entity#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG189742|UniProtKB=T1FRB9 T1FRB9 20211366 PTHR10288:SF340 KH DOMAIN CONTAINING RNA BINDING PROTEIN HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG158069|UniProtKB=T1EMJ0 T1EMJ0 20197790 PTHR12629:SF0 DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG159201|UniProtKB=T1ENQ7 T1ENQ7 20198207 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191028|UniProtKB=T1FSI6 T1FSI6 20211783 PTHR21669:SF1 CAPZ-INTERACTING PROTEIN AND RELATED PROTEINS WASH COMPLEX SUBUNIT 2 protein-containing complex binding#GO:0044877;lipid binding#GO:0008289;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981;binding#GO:0005488 localization#GO:0051179;endosomal transport#GO:0016197;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365;cellular process#GO:0009987;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147;protein localization#GO:0008104 cytoplasm#GO:0005737;endosome#GO:0005768;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185510|UniProtKB=T1FMW9 T1FMW9 20210168 PTHR46088:SF1 TUBULIN--TYROSINE LIGASE-LIKE PROTEIN 12 TUBULIN--TYROSINE LIGASE-LIKE PROTEIN 12 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG73864|UniProtKB=T1G1J6 T1G1J6 20214944 PTHR45957:SF1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 2 ANAPHASE-PROMOTING COMPLEX SUBUNIT 2 regulation of chromosome segregation#GO:0051983;mitotic cell cycle phase transition#GO:0044772;macromolecule modification#GO:0043412;cell cycle process#GO:0022402;protein modification process#GO:0036211;regulation of cellular component organization#GO:0051128;post-translational protein modification#GO:0043687;mitotic cell cycle process#GO:1903047;regulation of biological process#GO:0050789;mitotic cell cycle#GO:0000278;nitrogen compound metabolic process#GO:0006807;protein polyubiquitination#GO:0000209;protein K11-linked ubiquitination#GO:0070979;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;regulation of chromosome organization#GO:0033044;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule metabolic process#GO:0043170;regulation of organelle organization#GO:0033043;organonitrogen compound metabolic process#GO:1901564;cellular process#GO:0009987;cell cycle phase transition#GO:0044770;regulation of cell cycle process#GO:0010564;primary metabolic process#GO:0044238;metaphase/anaphase transition of cell cycle#GO:0044784;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;cell cycle#GO:0007049;regulation of sister chromatid segregation#GO:0033045;metaphase/anaphase transition of mitotic cell cycle#GO:0007091 ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234;anaphase-promoting complex#GO:0005680;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 Cell cycle#P00013>APC#P00481 HELRO|EnsemblGenome=HelroG103503|UniProtKB=T1EDG5 T1EDG5 20194617 PTHR14145:SF1 26S PROTESOME SUBUNIT 6 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG109833|UniProtKB=T1EEW7 T1EEW7 20195119 PTHR10378:SF19 LIM DOMAIN-BINDING PROTEIN CHIP, ISOFORM B positive regulation of nitrogen compound metabolic process#GO:0051173;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of RNA metabolic process#GO:0051253;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of transcription by RNA polymerase II#GO:0000122;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;regulation of DNA-templated transcription#GO:0006355;negative regulation of metabolic process#GO:0009892;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG174778|UniProtKB=T1F8G6 T1F8G6 20205115 PTHR28598:SF1 STAGA COMPLEX 65 SUBUNIT GAMMA STAGA COMPLEX 65 SUBUNIT GAMMA transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;molecular adaptor activity#GO:0060090;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 HELRO|EnsemblGenome=HelroG186002|UniProtKB=T1FNJ2 T1FNJ2 20210389 PTHR22748:SF6 AP ENDONUCLEASE DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE hydrolase activity, acting on ester bonds#GO:0016788;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;3'-5'-DNA exonuclease activity#GO:0008296;nuclease activity#GO:0004518;DNA exonuclease activity#GO:0004529;catalytic activity#GO:0003824;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097;phosphoric diester hydrolase activity#GO:0008081;exonuclease activity#GO:0004527;3'-5' exonuclease activity#GO:0008408;phosphoric ester hydrolase activity#GO:0042578 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;base-excision repair#GO:0006284;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 HELRO|EnsemblGenome=HelroG70858|UniProtKB=T1G0D1 T1G0D1 20214529 PTHR45810:SF1 HISTONE H3.2 HISTONE H3-LIKE CENTROMERIC PROTEIN A chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG117310|UniProtKB=T1EGL9 T1EGL9 20195719 PTHR20852:SF57 GLUTAMINE SYNTHETASE GLUTAMINE SYNTHETASE 2 CYTOPLASMIC ligase activity#GO:0016874;catalytic activity#GO:0003824 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;proteinogenic amino acid biosynthetic process#GO:0170038;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;alpha-amino acid biosynthetic process#GO:1901607;nitrogen compound metabolic process#GO:0006807;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;small molecule biosynthetic process#GO:0044283;L-amino acid biosynthetic process#GO:0170034;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 Glutamine glutamate conversion#P02745>Glutamine synthase#P04483;Glutamine glutamate conversion#P02745>Glutamine synthetase#P02968 HELRO|EnsemblGenome=HelroG87902|UniProtKB=T1G6W5 T1G6W5 20216812 PTHR11669:SF9 REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT REPLICATION FACTOR C SUBUNIT 5 ATP-dependent activity, acting on DNA#GO:0008094;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on DNA#GO:0140097;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;response to stress#GO:0006950;nitrogen compound metabolic process#GO:0006807;DNA-templated DNA replication#GO:0006261;DNA replication#GO:0006260;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;replication fork#GO:0005657 DNA-directed DNA polymerase#PC00018 DNA replication#P00017>RFC#P00529 HELRO|EnsemblGenome=HelroG107657|UniProtKB=T1EEC0 T1EEC0 20194922 PTHR12483:SF115 SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS COPPER TRANSPORT PROTEIN secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG184019|UniProtKB=T1FKF7 T1FKF7 20209306 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG150820|UniProtKB=T1EKH6 T1EKH6 20197076 PTHR24341:SF6 HOMEOBOX PROTEIN ENGRAILED HOMEOBOX PROTEIN INVECTED homeodomain transcription factor#PC00119 Wnt signaling pathway#P00057>Wnt Target Genes#G01558 HELRO|EnsemblGenome=HelroG186383|UniProtKB=T1FNY9 T1FNY9 20210536 PTHR16469:SF27 UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED HELRO|EnsemblGenome=HelroG171460|UniProtKB=T1F4B2 T1F4B2 20203661 PTHR46670:SF2 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG91510|UniProtKB=T1G846 T1G846 20217243 PTHR24060:SF171 METABOTROPIC GLUTAMATE RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;adenylate cyclase inhibiting G protein-coupled glutamate receptor activity#GO:0001640;G protein-coupled receptor activity#GO:0004930;glutamate receptor activity#GO:0008066;transmembrane signaling receptor activity#GO:0004888 regulation of cell communication#GO:0010646;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of signaling#GO:0023051;cell communication#GO:0007154;cellular process#GO:0009987;glutamate receptor signaling pathway#GO:0007215;regulation of synaptic transmission, glutamatergic#GO:0051966;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;modulation of chemical synaptic transmission#GO:0050804;biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG171466|UniProtKB=T1F4B6 T1F4B6 20203665 PTHR13817:SF171 TITIN STRETCHIN-MLCK, ISOFORM U structural protein#PC00211 HELRO|EnsemblGenome=HelroG167944|UniProtKB=T1EZZ8 T1EZZ8 20202148 PTHR38537:SF8 JITTERBUG, ISOFORM N FILAMIN-A HELRO|EnsemblGenome=HelroG184368|UniProtKB=T1FL25 T1FL25 20209524 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG80076|UniProtKB=T1G3X4 T1G3X4 20215772 PTHR19957:SF424 SYNTAXIN SYNTAXIN-1A molecular adaptor activity#GO:0060090;protein binding#GO:0005515;SNAP receptor activity#GO:0005484;binding#GO:0005488;SNARE binding#GO:0000149;protein-macromolecule adaptor activity#GO:0030674 vesicle fusion#GO:0006906;cellular localization#GO:0051641;organelle localization#GO:0051640;macromolecule localization#GO:0033036;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;membrane fusion#GO:0061025;exocytosis#GO:0006887;establishment of localization#GO:0051234;organelle organization#GO:0006996;secretion#GO:0046903;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;vesicle organization#GO:0016050;intracellular transport#GO:0046907;export from cell#GO:0140352;secretion by cell#GO:0032940;organelle fusion#GO:0048284 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;SNARE complex#GO:0031201;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034;membrane traffic protein#PC00150 Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079 HELRO|EnsemblGenome=HelroG191761|UniProtKB=T1FTA5 T1FTA5 20212052 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192720|UniProtKB=T1FU80 T1FU80 20212376 PTHR11125:SF7 SUPPRESSOR OF TY 5 TRANSCRIPTION ELONGATION FACTOR SPT5 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;DNA-templated transcription elongation#GO:0006354;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nucleobase-containing compound biosynthetic process#GO:0034654;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;transcription elongation by RNA polymerase II#GO:0006368;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;transcription elongation factor complex#GO:0008023;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG79229|UniProtKB=T1G3L5 T1G3L5 20215663 PTHR14140:SF45 E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED RING-TYPE E3 UBIQUITIN TRANSFERASE transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;protein-DNA complex organization#GO:0071824;negative regulation of biological process#GO:0048519;macromolecule modification#GO:0043412;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;regulation of biological process#GO:0050789;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;negative regulation of cellular process#GO:0048523;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;cellular component organization#GO:0016043;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression, epigenetic#GO:0045814;cellular process#GO:0009987;primary metabolic process#GO:0044238;epigenetic regulation of gene expression#GO:0040029;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;protein-containing complex organization#GO:0043933;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG104248|UniProtKB=T1EDK6 T1EDK6 20194658 PTHR12300:SF161 HVA22-LIKE PROTEINS RECEPTOR EXPRESSION-ENHANCING PROTEIN membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG107767|UniProtKB=T1EEC6 T1EEC6 20194928 PTHR11864:SF0 PRE-MRNA-PROCESSING PROTEIN PRP40 PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST) nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;mRNA splicing, via spliceosome#GO:0000398;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;U1 snRNP#GO:0005685;U2-type spliceosomal complex#GO:0005684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;U2-type prespliceosome#GO:0071004;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG74868|UniProtKB=T1G1W7 T1G1W7 20215065 PTHR22604:SF105 OXIDOREDUCTASES TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG169612|UniProtKB=T1F260 T1F260 20202910 PTHR15034:SF5 DEATH DOMAIN-CONTAINING PROTEIN CRADD DEATH DOMAIN-CONTAINING PROTEIN CRADD Wnt signaling pathway#P00057>Frizzled#P01428;Apoptosis signaling pathway#P00006>RAIDD#P00294;Cadherin signaling pathway#P00012>Frizzled#P00475;Alzheimer disease-presenilin pathway#P00004>Frizzled#P00119 HELRO|EnsemblGenome=HelroG193260|UniProtKB=T1FUT1 T1FUT1 20212577 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188230|UniProtKB=T1FPS7 T1FPS7 20210824 PTHR16171:SF7 DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED DNA REPAIR PROTEIN RAD2 hydrolase activity, acting on ester bonds#GO:0016788;DNA endonuclease activity#GO:0004520;nucleic acid binding#GO:0003676;nuclease activity#GO:0004518;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;single-stranded DNA binding#GO:0003697;DNA binding#GO:0003677;endonuclease activity#GO:0004519;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG169602|UniProtKB=T1F256 T1F256 20202906 PTHR22760:SF3 GLYCOSYLTRANSFERASE GPI MANNOSYLTRANSFERASE 4 mannosyltransferase activity#GO:0000030;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;phospholipid biosynthetic process#GO:0008654;macromolecule modification#GO:0043412;phosphatidylinositol biosynthetic process#GO:0006661;organophosphate biosynthetic process#GO:0090407;glycolipid metabolic process#GO:0006664;protein modification process#GO:0036211;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;glycerolipid biosynthetic process#GO:0045017;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;organic substance biosynthetic process#GO:1901576;liposaccharide metabolic process#GO:1903509;cellular process#GO:0009987;membrane lipid biosynthetic process#GO:0046467;GPI anchor metabolic process#GO:0006505;lipoprotein biosynthetic process#GO:0042158;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;GPI anchor biosynthetic process#GO:0006506;membrane lipid metabolic process#GO:0006643;glycerophospholipid biosynthetic process#GO:0046474;glycolipid biosynthetic process#GO:0009247;organophosphate metabolic process#GO:0019637;lipoprotein metabolic process#GO:0042157;cellular lipid metabolic process#GO:0044255 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;endoplasmic reticulum membrane#GO:0005789 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG186788|UniProtKB=T1FP36 T1FP36 20210583 PTHR11062:SF381 EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED EXOSTOSIN-2 acetylglucosaminyltransferase activity#GO:0008375;glucuronosyltransferase activity#GO:0015020;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG185445|UniProtKB=T1FMU2 T1FMU2 20210141 PTHR11227:SF29 WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED WD REPEAT DOMAIN PHOSPHOINOSITIDE-INTERACTING PROTEIN 4 phosphatidylinositol-3-phosphate binding#GO:0032266;phosphatidylinositol bisphosphate binding#GO:1902936;small molecule binding#GO:0036094;binding#GO:0005488;lipid binding#GO:0008289;phosphatidylinositol binding#GO:0035091;anion binding#GO:0043168;ion binding#GO:0043167;phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981 cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;macroautophagy#GO:0016236;macromolecule localization#GO:0033036;macromolecule modification#GO:0043412;protein modification process#GO:0036211;autophagy of mitochondrion#GO:0000422;biosynthetic process#GO:0009058;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;cellular component disassembly#GO:0022411;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;mitochondrion organization#GO:0007005;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organelle disassembly#GO:1903008;lipoprotein biosynthetic process#GO:0042158;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular macromolecule localization#GO:0070727;organelle organization#GO:0006996;autophagosome assembly#GO:0000045;lipoprotein metabolic process#GO:0042157;autophagy#GO:0006914 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;phagophore assembly site#GO:0000407;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;extrinsic component of membrane#GO:0019898 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG155709|UniProtKB=T1ELL3 T1ELL3 20197463 PTHR10024:SF344 SYNAPTOTAGMIN SYNAPTOTAGMIN-7 cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;phosphatidylserine binding#GO:0001786;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;protein binding#GO:0005515;clathrin binding#GO:0030276;lipid binding#GO:0008289;ion binding#GO:0043167;phospholipid binding#GO:0005543;SNARE binding#GO:0000149 vesicle fusion#GO:0006906;cellular localization#GO:0051641;synaptic vesicle cycle#GO:0099504;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;regulated exocytosis#GO:0045055;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;secretion#GO:0046903;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;signal release#GO:0023061;vesicle organization#GO:0016050;calcium-ion regulated exocytosis#GO:0017156;signaling#GO:0023052;cell-cell signaling#GO:0007267;synaptic vesicle exocytosis#GO:0016079;organelle fusion#GO:0048284;secretion by cell#GO:0032940;neurotransmitter secretion#GO:0007269;trans-synaptic signaling#GO:0099537;vesicle-mediated transport#GO:0016192;cell communication#GO:0007154;cellular component organization#GO:0016043;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;membrane fusion#GO:0061025;signal release from synapse#GO:0099643;exocytosis#GO:0006887;organelle organization#GO:0006996;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;export from cell#GO:0140352;vesicle-mediated transport in synapse#GO:0099003 synapse#GO:0045202;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;axon#GO:0030424;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;neuron projection#GO:0043005;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;transport vesicle#GO:0030133;cell projection#GO:0042995;secretory vesicle#GO:0099503;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG69342|UniProtKB=T1FZT5 T1FZT5 20214333 PTHR11947:SF3 PYRUVATE DEHYDROGENASE KINASE [PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;regulation of metabolic process#GO:0019222;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG165541|UniProtKB=T1EWZ7 T1EWZ7 20201097 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG163309|UniProtKB=T1ETW2 T1ETW2 20200012 PTHR14399:SF5 P53-INDUCED PROTEIN RELATED CELL JUNCTION PROTEIN VAB-9 cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987 cell junction#GO:0030054;cellular anatomical entity#GO:0110165;anchoring junction#GO:0070161;cell-cell junction#GO:0005911 HELRO|EnsemblGenome=HelroG86353|UniProtKB=T1G6B0 T1G6B0 20216607 PTHR11199:SF0 STROMAL ANTIGEN LD34181P-RELATED protein-containing complex binding#GO:0044877;binding#GO:0005488;chromatin binding#GO:0003682 cellular component organization or biogenesis#GO:0071840;sister chromatid cohesion#GO:0007062;organelle organization#GO:0006996;chromosome organization#GO:0051276;cell cycle process#GO:0022402;cell cycle#GO:0007049;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;chromosome#GO:0005694;chromatin#GO:0000785;cohesin complex#GO:0008278;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG83126|UniProtKB=T1G506 T1G506 20216154 PTHR12450:SF14 DENTIN MATRIX PROTEIN 4 PROTEIN FAM20 GLYCOSAMINOGLYCAN XYLOSYLKINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG126488|UniProtKB=T1EH99 T1EH99 20195949 PTHR12146:SF0 40S RIBOSOMAL PROTEIN S10 RIBOSOMAL PROTEIN S10 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;small ribosomal subunit#GO:0015935;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG154876|UniProtKB=T1ELG3 T1ELG3 20197413 PTHR48043:SF145 EG:EG0003.4 PROTEIN-RELATED FI06409P-RELATED HELRO|EnsemblGenome=HelroG105263|UniProtKB=T1EDS6 T1EDS6 20194728 PTHR11610:SF173 LIPASE LIPASE DOMAIN-CONTAINING PROTEIN-RELATED hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;lipid catabolic process#GO:0016042;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 lipase#PC00143;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG77725|UniProtKB=T1G332 T1G332 20215480 PTHR12246:SF13 PALMITOYLTRANSFERASE ZDHHC16 PALMITOYLTRANSFERASE ZDHHC16 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG172661|UniProtKB=T1F5R2 T1F5R2 20204161 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG72098|UniProtKB=T1G0V6 T1G0V6 20214704 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;heme binding#GO:0020037 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG114448|UniProtKB=T1EG18 T1EG18 20195520 PTHR14557:SF5 PROTEIN C7ORF21 UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN response to organic substance#GO:0010033;macromolecule catabolic process#GO:0009057;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;response to organonitrogen compound#GO:0010243;ERAD pathway#GO:0036503;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;cellular response to stress#GO:0033554;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG187181|UniProtKB=T1FP75 T1FP75 20210622 PTHR10701:SF0 SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B ribonucleoprotein complex binding#GO:0043021;protein-containing complex binding#GO:0044877;binding#GO:0005488 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;mRNA splicing, via spliceosome#GO:0000398;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 catalytic step 2 spliceosome#GO:0071013;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;U4/U6 x U5 tri-snRNP complex#GO:0046540;U1 snRNP#GO:0005685;U2-type spliceosomal complex#GO:0005684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;U4 snRNP#GO:0005687;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;U5 snRNP#GO:0005682;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;U2 snRNP#GO:0005686;U2-type prespliceosome#GO:0071004;spliceosomal tri-snRNP complex#GO:0097526;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG69616|UniProtKB=T1FZX2 T1FZX2 20214370 PTHR24345:SF0 SERINE/THREONINE-PROTEIN KINASE PLK CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185496|UniProtKB=T1FMW2 T1FMW2 20210161 PTHR19317:SF0 PRENYLATED RAB ACCEPTOR 1-RELATED PRENYLATED RAB ACCEPTOR PROTEIN 1 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG161468|UniProtKB=T1ERI0 T1ERI0 20199180 PTHR24341:SF6 HOMEOBOX PROTEIN ENGRAILED HOMEOBOX PROTEIN INVECTED homeodomain transcription factor#PC00119 Wnt signaling pathway#P00057>Wnt Target Genes#G01558 HELRO|EnsemblGenome=HelroG189913|UniProtKB=T1FRH3 T1FRH3 20211420 PTHR11584:SF394 SERINE/THREONINE PROTEIN KINASE APOPTOTIC SIGNAL-REGULATING KINASE 1, ISOFORM C transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 FGF signaling pathway#P00021>MEKK1-5#P00634;EGF receptor signaling pathway#P00018>MEKK1-5#P00553 HELRO|EnsemblGenome=HelroG175775|UniProtKB=T1F9N0 T1F9N0 20205529 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157401|UniProtKB=T1EMB0 T1EMB0 20197710 PTHR11124:SF12 VACUOLAR SORTING PROTEIN VPS29 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 29 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG185659|UniProtKB=T1FN36 T1FN36 20210234 PTHR11205:SF18 RIBOSOMAL PROTEIN S7 SMALL RIBOSOMAL SUBUNIT PROTEIN US7 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159;mRNA binding#GO:0003729;rRNA binding#GO:0019843 cellular component biogenesis#GO:0044085;peptide metabolic process#GO:0006518;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;translation#GO:0006412;protein-RNA complex assembly#GO:0022618;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;ribosome biogenesis#GO:0042254;non-membrane-bounded organelle assembly#GO:0140694;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;peptide biosynthetic process#GO:0043043;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;ribonucleoprotein complex biogenesis#GO:0022613;protein-RNA complex organization#GO:0071826;ribosomal small subunit biogenesis#GO:0042274 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;cytosol#GO:0005829;small ribosomal subunit#GO:0015935;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG110669|UniProtKB=T1EF41 T1EF41 20195193 PTHR11567:SF25 ACID PHOSPHATASE-RELATED PROTEIN FRA10AC1 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 cellular metabolic process#GO:0044237;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;dephosphorylation#GO:0016311;metabolic process#GO:0008152 metabolite interconversion enzyme#PC00262;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG185820|UniProtKB=T1FNC0 T1FNC0 20210317 PTHR11863:SF226 STEROL DESATURASE FATTY ACID HYDROXYLASE DOMAIN-CONTAINING PROTEIN 2-RELATED oxidase#PC00175;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG173558|UniProtKB=T1F6Z1 T1F6Z1 20204590 PTHR11615:SF258 NITRATE, FORMATE, IRON DEHYDROGENASE CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR CG17683-RELATED dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG174891|UniProtKB=T1F8K9 T1F8K9 20205158 PTHR16057:SF1 WINS1, 2 PROTEIN PROTEIN LINES HOMOLOG 1 HELRO|EnsemblGenome=HelroG86064|UniProtKB=T1G668 T1G668 20216565 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG86847|UniProtKB=T1G6I2 T1G6I2 20216679 PTHR24068:SF135 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 J2 ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule modification#GO:0043412;protein catabolic process#GO:0030163;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;protein ubiquitination#GO:0016567;macromolecule catabolic process#GO:0009057;response to endoplasmic reticulum stress#GO:0034976;protein modification by small protein conjugation or removal#GO:0070647;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;ERAD pathway#GO:0036503;response to organonitrogen compound#GO:0010243;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;cellular response to stress#GO:0033554 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Parkinson disease#P00049>Ubc6#P01222 HELRO|EnsemblGenome=HelroG96186|UniProtKB=T1G9A6 T1G9A6 20217653 PTHR11977:SF51 VILLIN PROTEIN FLIGHTLESS-1 HOMOLOG non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG182058|UniProtKB=T1FHP0 T1FHP0 20208339 PTHR19282:SF431 TETRASPANIN TETRASPANIN 26A, ISOFORM B-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG184364|UniProtKB=T1FL21 T1FL21 20209520 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG63722|UniProtKB=T1FXJ2 T1FXJ2 20213540 PTHR31978:SF1 INTRAFLAGELLAR TRANSPORT PROTEIN 20 HOMOLOG INTRAFLAGELLAR TRANSPORT PROTEIN 20 HOMOLOG cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;cilium assembly#GO:0060271;cell projection organization#GO:0030030;macromolecule localization#GO:0033036;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;protein localization#GO:0008104;localization#GO:0051179;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular macromolecule localization#GO:0070727;protein localization to cilium#GO:0061512;organelle organization#GO:0006996;protein localization to organelle#GO:0033365;plasma membrane bounded cell projection assembly#GO:0120031 microtubule organizing center#GO:0005815;non-motile cilium#GO:0097730;ciliary base#GO:0097546;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929;intraciliary transport particle#GO:0030990 HELRO|EnsemblGenome=HelroG161296|UniProtKB=T1ERB0 T1ERB0 20199110 PTHR12461:SF106 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED BIFUNCTIONAL PEPTIDASE AND ARGINYL-HYDROXYLASE JMJD5 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG183364|UniProtKB=T1FJI5 T1FJI5 20208984 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG67163|UniProtKB=T1FYX6 T1FYX6 20214024 PTHR10250:SF26 MICROSOMAL GLUTATHIONE S-TRANSFERASE GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL glutathione transferase activity#GO:0004364;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;antioxidant activity#GO:0016209;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 envelope#GO:0031975;cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG67918|UniProtKB=T1FZ77 T1FZ77 20214125 PTHR43215:SF14 RADIAL SPOKE HEAD 1 HOMOLOG RADIAL SPOKE HEAD 1 HOMOLOG HELRO|EnsemblGenome=HelroG64773|UniProtKB=T1FXZ1 T1FXZ1 20213689 PTHR22804:SF57 AGGRECAN/VERSICAN PROTEOGLYCAN NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2 extracellular matrix glycoprotein#PC00100 Notch signaling pathway#P00045>Notch#P01099;Angiogenesis#P00005>Notch#P00255;Notch signaling pathway#P00045>NIct#P01119;Alzheimer disease-presenilin pathway#P00004>Notch N-terminal fragment#P00171;Notch signaling pathway#P00045>NIcs#P01120;Notch signaling pathway#P00045>Ntm#P01114;Alzheimer disease-presenilin pathway#P00004>Notch C-terminal fragment#P00120;Notch signaling pathway#P00045>Next#P01103;Alzheimer disease-presenilin pathway#P00004>NICD#P00122;Alzheimer disease-presenilin pathway#P00004>Notch#P00176;Alzheimer disease-presenilin pathway#P00004>Notch fragment#P00154;Alzheimer disease-presenilin pathway#P00004>Notch transmembrane fragment#P00135;Alzheimer disease-presenilin pathway#P00004>Notch extracellular fragment#P00179 HELRO|EnsemblGenome=HelroG113575|UniProtKB=T1EFU0 T1EFU0 20195442 PTHR48153:SF2 UFM1-SPECIFIC PROTEASE 2 UFM1-SPECIFIC PROTEASE 2 cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG192412|UniProtKB=T1FTX7 T1FTX7 20212274 PTHR10555:SF170 SORTING NEXIN FI18122P1 lipid binding#GO:0008289;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;binding#GO:0005488 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG100903|UniProtKB=T1ED19 T1ED19 20194471 PTHR15481:SF0 RIBONUCLEIC ACID BINDING PROTEIN S1 LD23870P-RELATED cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG152794|UniProtKB=T1EKX0 T1EKX0 20197220 PTHR19359:SF150 CYTOCHROME B5 CYTOCHROME B5 tetrapyrrole binding#GO:0046906;binding#GO:0005488;organic cyclic compound binding#GO:0097159;heme binding#GO:0020037 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG174523|UniProtKB=T1F880 T1F880 20205029 PTHR28348:SF1 UPF0193 PROTEIN EVG1 UPF0193 PROTEIN EVG1 HELRO|EnsemblGenome=HelroG181447|UniProtKB=T1FH06 T1FH06 20208105 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED BRCT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159700|UniProtKB=T1EPB9 T1EPB9 20198419 PTHR23114:SF17 M7GPPPN-MRNA HYDROLASE M7GPPPN-MRNA HYDROLASE cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG167320|UniProtKB=T1EZ92 T1EZ92 20201892 PTHR23186:SF4 RETINOIC ACID-INDUCED PROTEIN 2 GH22790P anatomical structure development#GO:0048856;animal organ development#GO:0048513;developmental process#GO:0032502 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG178125|UniProtKB=T1FCS5 T1FCS5 20206624 PTHR24230:SF75 G-PROTEIN COUPLED RECEPTOR RELAXIN FAMILY PEPTIDE RECEPTOR 3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;neuropeptide signaling pathway#GO:0007218;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG167236|UniProtKB=T1EZ60 T1EZ60 20201860 PTHR12599:SF0 PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;catalytic activity#GO:0003824;hydro-lyase activity#GO:0016836 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG154769|UniProtKB=T1ELG1 T1ELG1 20197411 PTHR21737:SF4 POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3 SPLICING FACTOR CACTIN cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;mRNA cis splicing, via spliceosome#GO:0045292;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG84767|UniProtKB=T1G5N5 T1G5N5 20216382 PTHR45827:SF1 SORTING NEXIN SORTING NEXIN lipid binding#GO:0008289;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;binding#GO:0005488 endosomal transport#GO:0016197;cellular localization#GO:0051641;membrane organization#GO:0061024;plasma membrane organization#GO:0007009;transport#GO:0006810;endocytosis#GO:0006897;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;import into cell#GO:0098657 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG172602|UniProtKB=T1F5L5 T1F5L5 20204114 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG191746|UniProtKB=T1FT94 T1FT94 20212041 PTHR11347:SF179 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 3',5'-CYCLIC PHOSPHODIESTERASE PDE-3-RELATED hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric diester hydrolase activity#GO:0008081;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;cAMP-mediated signaling#GO:0019933;signaling#GO:0023052;cyclic-nucleotide-mediated signaling#GO:0019935 phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG159400|UniProtKB=T1EP03 T1EP03 20198303 PTHR34639:SF1 PROTEIN FLATTOP PROTEIN FLATTOP cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;cellular component organization#GO:0016043;cellular process#GO:0009987;cell projection organization#GO:0030030;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cilium#GO:0005929;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG183300|UniProtKB=T1FJF7 T1FJF7 20208956 PTHR19134:SF536 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE DOMAIN-CONTAINING PROTEIN hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG83315|UniProtKB=T1G541 T1G541 20216189 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG174878|UniProtKB=T1F8K4 T1F8K4 20205153 PTHR15510:SF5 SPERM-ASSOCIATED ANTIGEN 8 SPERM-ASSOCIATED ANTIGEN 8 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG172886|UniProtKB=T1F626 T1F626 20204275 PTHR11412:SF136 MACROGLOBULIN / COMPLEMENT CD109 ANTIGEN protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG130526|UniProtKB=T1EHU1 T1EHU1 20196141 PTHR10027:SF33 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic ion-gated channel activity#GO:0022839;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium-activated cation channel activity#GO:0005227;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG150642|UniProtKB=T1EKG7 T1EKG7 20197067 PTHR45617:SF169 LEUCINE RICH REPEAT FAMILY PROTEIN LRRCT DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG193268|UniProtKB=T1FUT4 T1FUT4 20212580 PTHR13817:SF173 TITIN FRAZZLED structural protein#PC00211 HELRO|EnsemblGenome=HelroG169942|UniProtKB=T1F2G5 T1F2G5 20203015 PTHR13720:SF18 WD-40 REPEAT PROTEIN FI23230P1 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG168937|UniProtKB=T1F158 T1F158 20202558 PTHR13802:SF52 MUCIN 4-RELATED MUCIN-4 HELRO|EnsemblGenome=HelroG70422|UniProtKB=T1G064 T1G064 20214462 PTHR19960:SF25 TEKTIN TEKTIN-1 cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cilium or flagellum-dependent cell motility#GO:0001539;cell motility#GO:0048870;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;cilium movement involved in cell motility#GO:0060294;cilium movement#GO:0003341;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cilium-dependent cell motility#GO:0060285;microtubule-based process#GO:0007017;organelle organization#GO:0006996;plasma membrane bounded cell projection assembly#GO:0120031 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG179696|UniProtKB=T1FF15 T1FF15 20207414 PTHR46652:SF3 LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9 HELRO|EnsemblGenome=HelroG189144|UniProtKB=T1FQQ1 T1FQQ1 20211148 PTHR13844:SF82 SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D LD45195P membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG84665|UniProtKB=T1G5L5 T1G5L5 20216362 PTHR46809:SF2 STROMAL CELL-DERIVED FACTOR 2-LIKE PROTEIN GH21273P HELRO|EnsemblGenome=HelroG166737|UniProtKB=T1EYG4 T1EYG4 20201614 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG63344|UniProtKB=T1FXE5 T1FXE5 20213493 PTHR24093:SF369 CATION TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE calcium ion transmembrane transporter activity#GO:0015085;inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;P-type ion transporter activity#GO:0015662;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075 intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG68781|UniProtKB=T1FZJ5 T1FZJ5 20214243 PTHR22883:SF43 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE APP palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular localization#GO:0051641;macromolecule localization#GO:0033036;macromolecule modification#GO:0043412;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;protein palmitoylation#GO:0018345;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;localization within membrane#GO:0051668;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein localization to membrane#GO:0072657;organonitrogen compound biosynthetic process#GO:1901566;protein targeting#GO:0006605;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;protein acylation#GO:0043543;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipoprotein biosynthetic process#GO:0042158;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;lipoprotein metabolic process#GO:0042157 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG195072|UniProtKB=T1FWQ4 T1FWQ4 20213249 PTHR21284:SF12 EG:80H7.2 PROTEIN EG:80H7.2 PROTEIN HELRO|EnsemblGenome=HelroG114400|UniProtKB=T1EG14 T1EG14 20195516 PTHR14074:SF16 HELICASE WITH DEATH DOMAIN-RELATED ANTIVIRAL INNATE IMMUNE RESPONSE RECEPTOR RIG-I cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG75153|UniProtKB=T1G215 T1G215 20215113 PTHR12406:SF7 CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 4 hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824;triglyceride lipase activity#GO:0004806 lipid metabolic process#GO:0006629;triglyceride metabolic process#GO:0006641;neutral lipid catabolic process#GO:0046461;cellular metabolic process#GO:0044237;homeostatic process#GO:0042592;glycerolipid catabolic process#GO:0046503;lipid catabolic process#GO:0016042;triglyceride catabolic process#GO:0019433;chemical homeostasis#GO:0048878;cellular process#GO:0009987;acylglycerol metabolic process#GO:0006639;primary metabolic process#GO:0044238;acylglycerol catabolic process#GO:0046464;neutral lipid metabolic process#GO:0006638;glycerolipid metabolic process#GO:0046486;lipid homeostasis#GO:0055088;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;lipid droplet#GO:0005811;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 phospholipase#PC00186 HELRO|EnsemblGenome=HelroG72348|UniProtKB=T1G0Y7 T1G0Y7 20214735 PTHR12589:SF7 PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE 6-PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE HELRO|EnsemblGenome=HelroG69200|UniProtKB=T1FZQ9 T1FZQ9 20214307 PTHR10969:SF101 MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED 63 KDA SPERM FLAGELLAR MEMBRANE PROTEIN enzyme binding#GO:0019899;protein binding#GO:0005515;lipid binding#GO:0008289;phospholipid binding#GO:0005543;ubiquitin protein ligase binding#GO:0031625;binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389 cellular component biogenesis#GO:0044085;macroautophagy#GO:0016236;autophagy of mitochondrion#GO:0000422;response to extracellular stimulus#GO:0009991;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;cellular component disassembly#GO:0022411;cellular response to starvation#GO:0009267;catabolic process#GO:0009056;mitochondrion organization#GO:0007005;autophagosome maturation#GO:0097352;cellular response to extracellular stimulus#GO:0031668;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;cellular component assembly#GO:0022607;cellular response to stimulus#GO:0051716;protein-containing complex disassembly#GO:0032984;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cell communication#GO:0007154;response to nutrient levels#GO:0031667;cellular process#GO:0009987;organelle disassembly#GO:1903008;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to stress#GO:0006950;cellular response to nutrient levels#GO:0031669;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;response to starvation#GO:0042594;cellular response to external stimulus#GO:0071496;autophagosome assembly#GO:0000045;cellular response to stress#GO:0033554;autophagy#GO:0006914 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;autophagosome membrane#GO:0000421;intracellular membrane-bounded organelle#GO:0043231;vacuolar membrane#GO:0005774;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;autophagosome#GO:0005776;intracellular anatomical structure#GO:0005622 non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG170462|UniProtKB=T1F334 T1F334 20203233 PTHR13328:SF4 NEGATIVE ELONGATION FACTOR A NELF-A NEGATIVE ELONGATION FACTOR A HELRO|EnsemblGenome=HelroG62924|UniProtKB=T1FX78 T1FX78 20213426 PTHR24346:SF82 MAP/MICROTUBULE AFFINITY-REGULATING KINASE KP78A-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG112163|UniProtKB=T1EFH5 T1EFH5 20195327 PTHR12899:SF3 39S RIBOSOMAL PROTEIN L18, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN UL18M nucleic acid binding#GO:0003676;RNA binding#GO:0003723;rRNA binding#GO:0019843;binding#GO:0005488;organic cyclic compound binding#GO:0097159 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG176977|UniProtKB=T1FB32 T1FB32 20206031 PTHR31718:SF60 PLAT DOMAIN-CONTAINING PROTEIN LIPOXYGENASE HOMOLOGY DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG175609|UniProtKB=T1F9F3 T1F9F3 20205452 PTHR25462:SF305 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG67857|UniProtKB=T1FZ63 T1FZ63 20214111 PTHR10743:SF0 PROTEIN RER1 PROTEIN RER1 localization#GO:0051179;cellular localization#GO:0051641;protein localization to endoplasmic reticulum#GO:0070972;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;maintenance of location#GO:0051235;maintenance of location in cell#GO:0051651;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;transport#GO:0006810;vesicle-mediated transport#GO:0016192;protein localization to organelle#GO:0033365;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;protein localization#GO:0008104 cytoplasm#GO:0005737;bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG178204|UniProtKB=T1FCX9 T1FCX9 20206678 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163646|UniProtKB=T1EUB3 T1EUB3 20200163 PTHR19282:SF534 TETRASPANIN TETRASPANIN FAMILY-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG82642|UniProtKB=T1G4U5 T1G4U5 20216093 PTHR46641:SF25 FMRFAMIDE RECEPTOR-RELATED CNMAMIDE RECEPTOR-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG101382|UniProtKB=T1ED43 T1ED43 20194495 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG173047|UniProtKB=T1F6A6 T1F6A6 20204355 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189398|UniProtKB=T1FR08 T1FR08 20211255 PTHR46117:SF3 FI24210P1 FI24210P1 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG89164|UniProtKB=T1G794 T1G794 20216941 PTHR24089:SF57 SOLUTE CARRIER FAMILY 25 FI05451P carbohydrate derivative transmembrane transporter activity#GO:1901505;purine nucleotide transmembrane transporter activity#GO:0015216;nucleobase-containing compound transmembrane transporter activity#GO:0015932;transmembrane transporter activity#GO:0022857;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215 localization#GO:0051179;organic substance transport#GO:0071702;organophosphate ester transport#GO:0015748;establishment of localization#GO:0051234;organic anion transport#GO:0015711;nucleobase-containing compound transport#GO:0015931;transport#GO:0006810;nitrogen compound transport#GO:0071705;carbohydrate derivative transport#GO:1901264 mitochondrial carrier protein#PC00158;secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG160959|UniProtKB=T1EQW9 T1EQW9 20198969 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168768|UniProtKB=T1F0Y0 T1F0Y0 20202480 PTHR10838:SF20 SYNAPTOGYRIN SYNAPTOGYRIN synaptic vesicle membrane#GO:0030672;bounding membrane of organelle#GO:0098588;presynapse#GO:0098793;synapse#GO:0045202;synaptic vesicle#GO:0008021;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;cell junction#GO:0030054;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;vesicle membrane#GO:0012506;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;transport vesicle membrane#GO:0030658;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;transport vesicle#GO:0030133;cytoplasmic vesicle membrane#GO:0030659;secretory vesicle#GO:0099503;neuromuscular junction#GO:0031594 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG189195|UniProtKB=T1FQR9 T1FQR9 20211166 PTHR14491:SF7 SOSONDOWAH, ISOFORM G SOSONDOWAH, ISOFORM G HELRO|EnsemblGenome=HelroG105142|UniProtKB=T1EDR3 T1EDR3 20194715 PTHR11467:SF36 HISTONE H1 HISTONE 24-RELATED nucleosome binding#GO:0031491;nucleic acid binding#GO:0003676;chromatin DNA binding#GO:0031490;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;protein-containing complex binding#GO:0044877 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA metabolic process#GO:0051052;chromosome condensation#GO:0030261;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;cellular process#GO:0009987;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;regulation of macromolecule metabolic process#GO:0060255;organelle organization#GO:0006996;chromosome organization#GO:0051276;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA recombination#GO:0045910;negative regulation of DNA metabolic process#GO:0051053;regulation of DNA recombination#GO:0000018;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG189079|UniProtKB=T1FQM3 T1FQM3 20211120 PTHR23257:SF963 SERINE-THREONINE PROTEIN KINASE AT08303P transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG171749|UniProtKB=T1F4L7 T1F4L7 20203766 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG76209|UniProtKB=T1G2G8 T1G2G8 20215266 PTHR46473:SF10 GH08155P LD45603P-RELATED HELRO|EnsemblGenome=HelroG169005|UniProtKB=T1F191 T1F191 20202591 PTHR12107:SF0 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT STARGAZIN (MAMMALIAN CALCIUM CHANNEL) HOMOLOG calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;voltage-gated channel activity#GO:0022832;molecular function regulator activity#GO:0098772;transporter regulator activity#GO:0141108;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;channel regulator activity#GO:0016247;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;inorganic cation transmembrane transporter activity#GO:0022890 cellular localization#GO:0051641;macromolecule localization#GO:0033036;receptor internalization#GO:0031623;system process#GO:0003008;transport#GO:0006810;regulation of signaling#GO:0023051;nitrogen compound transport#GO:0071705;regulation of localization#GO:0032879;endosome to lysosome transport#GO:0008333;lysosomal transport#GO:0007041;establishment of protein localization#GO:0045184;regulation of biological process#GO:0050789;organic substance transport#GO:0071702;regulation of transport#GO:0051049;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;regulation of molecular function#GO:0065009;regulation of signal transduction#GO:0009966;receptor-mediated endocytosis#GO:0006898;regulation of monoatomic ion transmembrane transporter activity#GO:0032412;regulation of transmembrane transporter activity#GO:0022898;protein localization to organelle#GO:0033365;regulation of transporter activity#GO:0032409;positive regulation of signaling#GO:0023056;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;positive regulation of biological process#GO:0048518;localization within membrane#GO:0051668;regulation of cell communication#GO:0010646;establishment of protein localization to vacuole#GO:0072666;regulation of transmembrane transport#GO:0034762;vacuolar transport#GO:0007034;endocytosis#GO:0006897;protein localization to vacuole#GO:0072665;vesicle-mediated transport#GO:0016192;establishment of protein localization to organelle#GO:0072594;nervous system process#GO:0050877;cell communication#GO:0007154;cellular process#GO:0009987;regulation of synaptic transmission, glutamatergic#GO:0051966;protein localization#GO:0008104;positive regulation of cellular process#GO:0048522;localization#GO:0051179;regulation of response to stimulus#GO:0048583;protein localization to lysosome#GO:0061462;cellular macromolecule localization#GO:0070727;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;positive regulation of cell communication#GO:0010647;protein transport#GO:0015031;biological regulation#GO:0065007;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;regulation of trans-synaptic signaling#GO:0099177;multicellular organismal process#GO:0032501;intracellular transport#GO:0046907;positive regulation of synaptic transmission#GO:0050806;import into cell#GO:0098657;protein-containing complex localization#GO:0031503 membrane protein complex#GO:0098796;synapse#GO:0045202;postsynaptic specialization#GO:0099572;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;plasma membrane signaling receptor complex#GO:0098802;transporter complex#GO:1990351;plasma membrane protein complex#GO:0098797;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;neuron to neuron synapse#GO:0098984;membrane#GO:0016020;synaptic membrane#GO:0097060;asymmetric synapse#GO:0032279;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;transmembrane transporter complex#GO:1902495;postsynaptic density membrane#GO:0098839;postsynaptic specialization membrane#GO:0099634;plasma membrane region#GO:0098590;postsynapse#GO:0098794;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG81068|UniProtKB=T1G485 T1G485 20215883 PTHR15691:SF6 WASH COMPLEX SUBUNIT 5 WASH COMPLEX SUBUNIT 5 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;regulation of organelle organization#GO:0033043;protein-containing complex assembly#GO:0065003;endomembrane system organization#GO:0010256;actin polymerization or depolymerization#GO:0008154;regulation of actin filament organization#GO:0110053;actin filament polymerization#GO:0030041;regulation of cellular component organization#GO:0051128;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;endosome organization#GO:0007032;regulation of cytoskeleton organization#GO:0051493;actin filament-based process#GO:0030029;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;supramolecular fiber organization#GO:0097435;biological regulation#GO:0065007;protein polymerization#GO:0051258;actin filament organization#GO:0007015;regulation of actin cytoskeleton organization#GO:0032956;vesicle organization#GO:0016050;organelle fission#GO:0048285;cytoskeleton organization#GO:0007010;regulation of actin filament-based process#GO:0032970;actin cytoskeleton organization#GO:0030036 cytoplasm#GO:0005737;endosome#GO:0005768;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG158178|UniProtKB=T1EMK0 T1EMK0 20197800 PTHR48083:SF20 MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED LONG-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL nucleotide binding#GO:0000166;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;flavin adenine dinucleotide binding#GO:0050660;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;oxidoreductase activity#GO:0016491 oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;lipid oxidation#GO:0034440;cellular metabolic process#GO:0044237;lipid catabolic process#GO:0016042;lipid modification#GO:0030258;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;fatty acid catabolic process#GO:0009062;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;fatty acid metabolic process#GO:0006631;small molecule catabolic process#GO:0044282;fatty acid beta-oxidation#GO:0006635;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;carboxylic acid metabolic process#GO:0019752;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG64550|UniProtKB=T1FXW3 T1FXW3 20213661 PTHR18860:SF17 14-3-3 PROTEIN 14-3-3 PROTEIN EPSILON localization#GO:0051179;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular localization#GO:0051641;cellular response to stimulus#GO:0051716;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052;protein localization#GO:0008104 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 Parkinson disease#P00049>14-3-3#P01238;FGF signaling pathway#P00021>14-3-3#P00624;EGF receptor signaling pathway#P00018>14-3-3#P00539 HELRO|EnsemblGenome=HelroG189319|UniProtKB=T1FQY2 T1FQY2 20211229 PTHR45625:SF6 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein peptidyl-prolyl isomerization#GO:0000413;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ribonucleoprotein complex#GO:1990904;catalytic step 2 spliceosome#GO:0071013;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG185063|UniProtKB=T1FMC5 T1FMC5 20209974 PTHR19818:SF166 ZINC FINGER PROTEIN ZIC AND GLI C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG162289|UniProtKB=T1ESG6 T1ESG6 20199516 PTHR10985:SF77 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED GH26014P sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of multicellular organismal process#GO:0051239;regulation of cell development#GO:0060284;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regionalization#GO:0003002;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of RNA biosynthetic process#GO:2001141;regulation of multicellular organismal development#GO:2000026;regulation of cell differentiation#GO:0045595;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of neurogenesis#GO:0050767;regulation of macromolecule metabolic process#GO:0060255;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;regulation of nervous system development#GO:0051960;biological regulation#GO:0065007;anterior/posterior pattern specification#GO:0009952;multicellular organismal process#GO:0032501;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;pattern specification process#GO:0007389;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG163212|UniProtKB=T1ETT2 T1ETT2 20199982 PTHR13723:SF305 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE PROTEIN MADD-4 hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;cellular component organization#GO:0016043;cellular process#GO:0009987;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG178925|UniProtKB=T1FDW7 T1FDW7 20207016 PTHR15710:SF74 E3 UBIQUITIN-PROTEIN LIGASE PRAJA RING-TYPE E3 UBIQUITIN TRANSFERASE-RELATED ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG104131|UniProtKB=T1EDJ8 T1EDJ8 20194650 PTHR11638:SF93 ATP-DEPENDENT CLP PROTEASE MITOCHONDRIAL DISAGGREGASE pyrophosphatase activity#GO:0016462;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;response to stress#GO:0006950;response to heat#GO:0009408;cellular response to heat#GO:0034605;response to temperature stimulus#GO:0009266;response to abiotic stimulus#GO:0009628;cellular process#GO:0009987;cellular response to stress#GO:0033554 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protease#PC00190 HELRO|EnsemblGenome=HelroG173781|UniProtKB=T1F780 T1F780 20204679 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG107225|UniProtKB=T1EE88 T1EE88 20194890 PTHR10032:SF271 ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS RH12261P-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG173258|UniProtKB=T1F6M0 T1F6M0 20204469 PTHR12857:SF0 CXXC MOTIF CONTAINING ZINC BINDING PROTEIN CXXC MOTIF CONTAINING ZINC BINDING PROTEIN cation binding#GO:0043169;metal ion binding#GO:0046872;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;zinc ion binding#GO:0008270;transition metal ion binding#GO:0046914 HELRO|EnsemblGenome=HelroG183048|UniProtKB=T1FJ38 T1FJ38 20208837 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED FMRFAMIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG188001|UniProtKB=T1FPJ3 T1FPJ3 20210740 PTHR31540:SF1 CENTROSOMAL PROTEIN OF 131 KDA CENTROSOMAL PROTEIN OF 131 KDA HELRO|EnsemblGenome=HelroG187998|UniProtKB=T1FPJ1 T1FPJ1 20210738 PTHR21014:SF6 PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 4-PHOSPHATASE PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 4-PHOSPHATASE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 phospholipid dephosphorylation#GO:0046839;lipid metabolic process#GO:0006629;phosphatidylinositol dephosphorylation#GO:0046856;cellular metabolic process#GO:0044237;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;lipid modification#GO:0030258;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;dephosphorylation#GO:0016311;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 bounding membrane of organelle#GO:0098588;lytic vacuole membrane#GO:0098852;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vacuolar membrane#GO:0005774;late endosome membrane#GO:0031902;vacuole#GO:0005773;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endosome membrane#GO:0010008;lytic vacuole#GO:0000323;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;lysosomal membrane#GO:0005765;lysosome#GO:0005764;endomembrane system#GO:0012505;phagocytic vesicle#GO:0045335;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;plasma membrane#GO:0005886 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG191108|UniProtKB=T1FSL5 T1FSL5 20211812 PTHR24291:SF201 CYTOCHROME P450 FAMILY 4 CYTOCHROME P450, FAMILY 4, SUBFAMILY B, POLYPEPTIDE 7 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG185006|UniProtKB=T1FM97 T1FM97 20209946 PTHR46064:SF1 QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2 QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;tRNA metabolic process#GO:0006399;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG77371|UniProtKB=T1G2W9 T1G2W9 20215417 PTHR11920:SF501 GUANYLYL CYCLASE GUANYLATE CYCLASE 32E adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG185629|UniProtKB=T1FN24 T1FN24 20210223 PTHR10971:SF2 MRNA EXPORT FACTOR AND BUB3 DYNEIN AXONEMAL ASSEMBLY FACTOR 10 protein binding#GO:0005515;ubiquitin-like protein binding#GO:0032182;binding#GO:0005488;ubiquitin binding#GO:0043130 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG62277|UniProtKB=T1FWY4 T1FWY4 20213332 PTHR34932:SF1 TRPL TRANSLOCATION DEFECT PROTEIN 14 TRPL TRANSLOCATION DEFECT PROTEIN 14 nucleotide binding#GO:0000166;carbohydrate derivative binding#GO:0097367;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;lipid binding#GO:0008289;anion binding#GO:0043168;ion binding#GO:0043167;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543 HELRO|EnsemblGenome=HelroG192588|UniProtKB=T1FU39 T1FU39 20212335 PTHR45812:SF1 DNA POLYMERASE ZETA CATALYTIC SUBUNIT DNA POLYMERASE ZETA CATALYTIC SUBUNIT DNA-directed DNA polymerase activity#GO:0003887;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on DNA#GO:0140097;DNA polymerase activity#GO:0034061 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;double-strand break repair#GO:0006302;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;recombinational repair#GO:0000725;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;postreplication repair#GO:0006301;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;double-strand break repair via homologous recombination#GO:0000724;DNA recombination#GO:0006310;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;translesion synthesis#GO:0019985;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;nucleobase-containing compound biosynthetic process#GO:0034654;DNA biosynthetic process#GO:0071897;DNA synthesis involved in DNA repair#GO:0000731;aromatic compound biosynthetic process#GO:0019438;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259 DNA polymerase complex#GO:0042575;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622 DNA-directed DNA polymerase#PC00018 HELRO|EnsemblGenome=HelroG181288|UniProtKB=T1FGU7 T1FGU7 20208046 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189916|UniProtKB=T1FRH5 T1FRH5 20211422 PTHR10177:SF584 CYCLINS CYCLIN G protein kinase regulator activity#GO:0019887;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 regulation of protein kinase activity#GO:0045859;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;mitotic cell cycle phase transition#GO:0044772;regulation of nitrogen compound metabolic process#GO:0051171;cell cycle process#GO:0022402;regulation of catalytic activity#GO:0050790;cellular process#GO:0009987;cell cycle phase transition#GO:0044770;mitotic cell cycle process#GO:1903047;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;regulation of primary metabolic process#GO:0080090;mitotic cell cycle#GO:0000278;regulation of macromolecule metabolic process#GO:0060255;regulation of molecular function#GO:0065009;regulation of protein phosphorylation#GO:0001932;regulation of cellular process#GO:0050794;regulation of protein serine/threonine kinase activity#GO:0071900;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cyclin-dependent protein serine/threonine kinase activity#GO:0000079;regulation of kinase activity#GO:0043549;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622 kinase activator#PC00138 HELRO|EnsemblGenome=HelroG195146|UniProtKB=T1FWT1 T1FWT1 20213276 PTHR31954:SF1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157 cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cilium#GO:0005929;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 structural protein#PC00211 HELRO|EnsemblGenome=HelroG127018|UniProtKB=T1EHC2 T1EHC2 20195972 PTHR24333:SF5 HOMEO BOX HB9 LIKE A-RELATED VENT HOMEOBOX homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG185323|UniProtKB=T1FMN8 T1FMN8 20210087 PTHR10540:SF8 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED COP9 SIGNALOSOME COMPLEX SUBUNIT 6 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;COP9 signalosome#GO:0008180;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG178467|UniProtKB=T1FD75 T1FD75 20206774 PTHR46123:SF4 MIX-TYPE HOMEOBOX GENE 1-RELATED MIX-TYPE HOMEOBOX GENE 1-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG177918|UniProtKB=T1FCG8 T1FCG8 20206517 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG171017|UniProtKB=T1F3P8 T1F3P8 20203447 PTHR19282:SF551 TETRASPANIN RE08073P-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG171942|UniProtKB=T1F4V6 T1F4V6 20203855 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG109239|UniProtKB=T1EER8 T1EER8 20195070 PTHR44054:SF2 SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG-LIKE SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG-LIKE Huntington disease#P00029>PIG3#G01535 HELRO|EnsemblGenome=HelroG92274|UniProtKB=T1G8D6 T1G8D6 20217333 PTHR28163:SF1 PROTEIN PET117 HOMOLOG, MITOCHONDRIAL PROTEIN PET117 HOMOLOG, MITOCHONDRIAL cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;respiratory chain complex IV assembly#GO:0008535;mitochondrial respiratory chain complex assembly#GO:0033108;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;cytochrome complex assembly#GO:0017004;protein-containing complex assembly#GO:0065003;mitochondrial cytochrome c oxidase assembly#GO:0033617;mitochondrion organization#GO:0007005;cellular component organization#GO:0016043;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG177085|UniProtKB=T1FB80 T1FB80 20206079 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169105|UniProtKB=T1F1E5 T1F1E5 20202645 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193801|UniProtKB=T1FVD3 T1FVD3 20212779 PTHR15696:SF7 SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7 NONSENSE-MEDIATED MRNA DECAY FACTOR telomeric DNA binding#GO:0042162;sequence-specific DNA binding#GO:0043565;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;mRNA catabolic process#GO:0006402;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;negative regulation of cellular process#GO:0048523;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;nuclear-transcribed mRNA catabolic process#GO:0000956;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG192292|UniProtKB=T1FTS8 T1FTS8 20212225 PTHR10501:SF41 U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B PROTEIN COUCH POTATO nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG173518|UniProtKB=T1F6X4 T1F6X4 20204573 PTHR21461:SF87 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GH12965P transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 glycosylation#GO:0070085;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG146354|UniProtKB=T1EJR9 T1EJR9 20196819 PTHR14057:SF47 TRANSCRIPTION FACTOR ONECUT HOMEOBOX PROTEIN ONECUT sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG183810|UniProtKB=T1FK83 T1FK83 20209232 PTHR22929:SF0 RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG125254|UniProtKB=T1EH52 T1EH52 20195902 PTHR12999:SF17 ZINC FINGER RAN-BINDING DOMAIN-CONTAINING PROTEIN 2 ZRANB2-RELATED ZINC FINGER RAN-BINDING DOMAIN-CONTAINING PROTEIN 2 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG76698|UniProtKB=T1G2M7 T1G2M7 20215325 PTHR43115:SF4 DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 11 DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 11 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG164379|UniProtKB=T1EVC7 T1EVC7 20200527 PTHR23108:SF0 METHYLTRANSFERASE-RELATED METHYLTRANSFERASE-LIKE PROTEIN 22 methyltransferase activity#GO:0008168;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;protein methyltransferase activity#GO:0008276 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG167619|UniProtKB=T1EZK7 T1EZK7 20202007 PTHR24238:SF75 G-PROTEIN COUPLED RECEPTOR CHOLECYSTOKININ-LIKE RECEPTOR AT 17D1-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;neuropeptide signaling pathway#GO:0007218;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG159671|UniProtKB=T1EPA7 T1EPA7 20198407 PTHR10574:SF435 NETRIN/LAMININ-RELATED LAMININ SUBUNIT GAMMA-1 neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;cell projection organization#GO:0030030;animal organ development#GO:0048513;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;axonogenesis#GO:0007409;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization#GO:0016043;cell morphogenesis#GO:0000902;cellular process#GO:0009987;tissue development#GO:0009888;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure development#GO:0048856;animal organ morphogenesis#GO:0009887;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Laminin#P00947 HELRO|EnsemblGenome=HelroG184932|UniProtKB=T1FM64 T1FM64 20209913 PTHR39369:SF6 LIN-24 (TWENTY-FOUR) LIKE LIN-24 (TWENTY-FOUR) LIKE HELRO|EnsemblGenome=HelroG189905|UniProtKB=T1FRG9 T1FRG9 20211416 PTHR31395:SF26 SHISA STANLEY-CUP scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185332|UniProtKB=T1FMP2 T1FMP2 20210091 PTHR19919:SF0 WD REPEAT CONTAINING PROTEIN DDB1- AND CUL4-ASSOCIATED FACTOR 7 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG174351|UniProtKB=T1F813 T1F813 20204962 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG87916|UniProtKB=T1G6W9 T1G6W9 20216816 PTHR10210:SF53 RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER GH23275P carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;transferase activity#GO:0016740;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;transferase activity, transferring phosphorus-containing groups#GO:0016772;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168;ATP binding#GO:0005524 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695 nucleotide kinase#PC00172;kinase#PC00137 HELRO|EnsemblGenome=HelroG188838|UniProtKB=T1FQE7 T1FQE7 20211044 PTHR10809:SF6 VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN AT11025P-RELATED localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organelle localization#GO:0051640;endoplasmic reticulum organization#GO:0007029;membrane organization#GO:0061024;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;plasma membrane#GO:0005886;endoplasmic reticulum membrane#GO:0005789 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG182709|UniProtKB=T1FIM4 T1FIM4 20208673 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG80067|UniProtKB=T1G3X3 T1G3X3 20215771 PTHR12161:SF5 IST1 FAMILY MEMBER IST1 HOMOLOG localization#GO:0051179;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;cellular process#GO:0009987;macromolecule localization#GO:0033036;protein localization#GO:0008104 HELRO|EnsemblGenome=HelroG104089|UniProtKB=T1EDJ6 T1EDJ6 20194648 PTHR43550:SF3 3-KETODIHYDROSPHINGOSINE REDUCTASE 3-KETODIHYDROSPHINGOSINE REDUCTASE reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG114397|UniProtKB=T1EG13 T1EG13 20195515 PTHR15301:SF3 INSULIN-INDUCED GENE 1 PROTEIN NSG1-RELATED sterol metabolic process#GO:0016125;organic hydroxy compound metabolic process#GO:1901615;lipid metabolic process#GO:0006629;steroid metabolic process#GO:0008202;organic cyclic compound metabolic process#GO:1901360;organic hydroxy compound biosynthetic process#GO:1901617;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;lipid biosynthetic process#GO:0008610;steroid biosynthetic process#GO:0006694;metabolic process#GO:0008152;sterol biosynthetic process#GO:0016126;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG77046|UniProtKB=T1G2S6 T1G2S6 20215374 PTHR24356:SF414 SERINE/THREONINE-PROTEIN KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG166018|UniProtKB=T1EXL7 T1EXL7 20201317 PTHR33395:SF21 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED PERICARDIN heart morphogenesis#GO:0003007;system development#GO:0048731;heart development#GO:0007507;circulatory system development#GO:0072359;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;animal organ development#GO:0048513;multicellular organism development#GO:0007275;developmental process#GO:0032502;animal organ morphogenesis#GO:0009887;multicellular organismal process#GO:0032501;cell adhesion#GO:0007155;cellular process#GO:0009987;post-embryonic development#GO:0009791 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG183458|UniProtKB=T1FJP7 T1FJP7 20209046 PTHR15741:SF27 BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR AP-4 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG186060|UniProtKB=T1FNM0 T1FNM0 20210417 PTHR23088:SF30 NITRILASE-RELATED OMEGA-AMIDASE NIT2 hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;dicarboxylic acid metabolic process#GO:0043648;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;alpha-amino acid metabolic process#GO:1901605;aspartate family amino acid metabolic process#GO:0009066;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG75788|UniProtKB=T1G2A2 T1G2A2 20215200 PTHR11038:SF16 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10 cellular localization#GO:0051641;protein insertion into mitochondrial inner membrane#GO:0045039;macromolecule localization#GO:0033036;membrane organization#GO:0061024;transport#GO:0006810;nitrogen compound transport#GO:0071705;establishment of protein localization#GO:0045184;organic substance transport#GO:0071702;establishment of protein localization to membrane#GO:0090150;establishment of localization#GO:0051234;protein targeting to mitochondrion#GO:0006626;mitochondrion organization#GO:0007005;protein localization to organelle#GO:0033365;localization within membrane#GO:0051668;protein localization to membrane#GO:0072657;protein targeting#GO:0006605;establishment of protein localization to organelle#GO:0072594;cellular component organization#GO:0016043;cellular process#GO:0009987;protein localization to mitochondrion#GO:0070585;protein localization#GO:0008104;inner mitochondrial membrane organization#GO:0007007;mitochondrial transport#GO:0006839;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;cellular macromolecule localization#GO:0070727;organelle organization#GO:0006996;establishment of protein localization to mitochondrion#GO:0072655;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;mitochondrial membrane organization#GO:0007006 envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;organelle inner membrane#GO:0019866;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227 transporter#PC00227 HELRO|EnsemblGenome=HelroG170638|UniProtKB=T1F398 T1F398 20203297 PTHR14445:SF36 GRB10 INTERACTING GYF PROTEIN FI03272P-RELATED cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG114296|UniProtKB=T1EG06 T1EG06 20195508 PTHR11132:SF427 SOLUTE CARRIER FAMILY 35 SOLUTE CARRIER FAMILY 35 MEMBER E1 secondary active transmembrane transporter activity#GO:0015291;antiporter activity#GO:0015297;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG70670|UniProtKB=T1G0A4 T1G0A4 20214502 PTHR12596:SF2 EXPORTIN 4,7-RELATED EXPORTIN-7 ISOFORM X1 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;protein export from nucleus#GO:0006611;intracellular transport#GO:0046907;nuclear transport#GO:0051169 envelope#GO:0031975;cytoplasm#GO:0005737;nuclear pore#GO:0005643;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG167604|UniProtKB=T1EZJ4 T1EZJ4 20201994 PTHR11447:SF16 CELLULAR TUMOR ANTIGEN P53 P53 PROTEIN LONG FORM VARIANT 1 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 P53-like transcription factor#PC00253;immunoglobulin fold transcription factor#PC00251 Huntington disease#P00029>p53#P00797 HELRO|EnsemblGenome=HelroG194841|UniProtKB=T1FWH1 T1FWH1 20213166 PTHR13297:SF5 TBC1 DOMAIN FAMILY MEMBER 23-RELATED TBC1 DOMAIN FAMILY MEMBER 23 endosomal transport#GO:0016197;cellular localization#GO:0051641;organelle localization#GO:0051640;vesicle localization#GO:0051648;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;vesicle targeting#GO:0006903;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;establishment of vesicle localization#GO:0051650;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;establishment of organelle localization#GO:0051656 cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi apparatus subcompartment#GO:0098791;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG90384|UniProtKB=T1G7Q4 T1G7Q4 20217101 PTHR24179:SF29 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12 LD46604P phosphatase regulator activity#GO:0019208;enzyme inhibitor activity#GO:0004857;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG162707|UniProtKB=T1ET14 T1ET14 20199714 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG97044|UniProtKB=T1G9F0 T1G9F0 20217697 PTHR47385:SF14 CALPONIN TRANSGELIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG194207|UniProtKB=T1FVT1 T1FVT1 20212927 PTHR19282:SF551 TETRASPANIN RE08073P-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG81990|UniProtKB=T1G4L4 T1G4L4 20216012 PTHR47023:SF1 SEX PEPTIDE RECEPTOR SEX PEPTIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG115984|UniProtKB=T1EGC3 T1EGC3 20195625 PTHR19288:SF93 4-NITROPHENYLPHOSPHATASE-RELATED FI11325P-RELATED hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG163412|UniProtKB=T1EU06 T1EU06 20200056 PTHR15949:SF3 TESTIS-EXPRESSED PROTEIN 264 TESTIS-EXPRESSED PROTEIN 264 HELRO|EnsemblGenome=HelroG192857|UniProtKB=T1FUD3 T1FUD3 20212429 PTHR12604:SF2 KU AUTOANTIGEN DNA HELICASE X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6 telomeric DNA binding#GO:0042162;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;double-strand break repair#GO:0006302;telomere organization#GO:0032200;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;telomere maintenance#GO:0000723;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;double-strand break repair via nonhomologous end joining#GO:0006303;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;response to stress#GO:0006950;organelle organization#GO:0006996;chromosome organization#GO:0051276;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;metabolic process#GO:0008152 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA helicase#PC00011;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG175027|UniProtKB=T1F8Q8 T1F8Q8 20205207 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG159134|UniProtKB=T1ENM7 T1ENM7 20198177 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED FMRFAMIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG176397|UniProtKB=T1FAH2 T1FAH2 20205821 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG169349|UniProtKB=T1F1T5 T1F1T5 20202785 PTHR19336:SF9 UNCHARACTERIZED DUF1167 SPINDLE POLE BODY PROTEIN PPC89 cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 HELRO|EnsemblGenome=HelroG177165|UniProtKB=T1FBA9 T1FBA9 20206108 PTHR48233:SF4 MUCIN 4B, ISOFORM B-RELATED MUCIN 4B, ISOFORM B-RELATED HELRO|EnsemblGenome=HelroG175174|UniProtKB=T1F8Y8 T1F8Y8 20205287 PTHR10938:SF0 TRANSLATION INITIATION FACTOR IF-3 TRANSLATION INITIATION FACTOR IF-3, MITOCHONDRIAL nucleic acid binding#GO:0003676;translation regulator activity#GO:0045182;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation initiation factor activity#GO:0003743;ribonucleoprotein complex binding#GO:0043021;ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877;translation regulator activity, nucleic acid binding#GO:0090079;translation factor activity, RNA binding#GO:0008135 cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cellular component disassembly#GO:0022411;cellular process#GO:0009987;organelle organization#GO:0006996;organelle disassembly#GO:1903008 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG103740|UniProtKB=T1EDH1 T1EDH1 20194623 PTHR48051:SF46 FAMILY NOT NAMED LEUCINE RICH REPEAT-CONTAINING DOMAIN PROTEIN cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG75936|UniProtKB=T1G2C9 T1G2C9 20215227 PTHR23003:SF51 RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN SERINE-ARGININE PROTEIN 55 nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG108452|UniProtKB=T1EEJ0 T1EEJ0 20194992 PTHR42861:SF29 CALCIUM-TRANSPORTING ATPASE SECRETORY PATHWAY CALCIUM ATPASE, ISOFORM G calcium ion transmembrane transporter activity#GO:0015085;inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;P-type ion transporter activity#GO:0015662;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;inorganic cation transmembrane transporter activity#GO:0022890;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;calcium ion transport#GO:0006816;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation transport#GO:0006812;transition metal ion transport#GO:0000041;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG184716|UniProtKB=T1FLU6 T1FLU6 20209795 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173167|UniProtKB=T1F6H8 T1F6H8 20204427 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG137856|UniProtKB=T1EIP3 T1EIP3 20196443 PTHR48034:SF4 TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED NUCLEOLIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 positive regulation of gene expression#GO:0010628;positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of mRNA metabolic process#GO:1903313;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of mRNA processing#GO:0050684;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule biosynthetic process#GO:0010556;regulation of mRNA splicing, via spliceosome#GO:0048024;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG81288|UniProtKB=T1G4C6 T1G4C6 20215924 PTHR10217:SF548 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL GH12235P monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG147455|UniProtKB=T1EK06 T1EK06 20196906 PTHR48112:SF32 HIGH MOBILITY GROUP PROTEIN DSP1 HIGH MOBILITY GROUP PROTEIN B3 HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG165753|UniProtKB=T1EX91 T1EX91 20201191 PTHR47027:SF25 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175906|UniProtKB=T1F9V2 T1F9V2 20205601 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG71899|UniProtKB=T1G0S7 T1G0S7 20214675 PTHR11753:SF5 ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY AP COMPLEX SUBUNIT SIGMA localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;cellular process#GO:0009987;transport#GO:0006810 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG72412|UniProtKB=T1G0Z6 T1G0Z6 20214744 PTHR21396:SF2 39S RIBOSOMAL PROTEIN L43 LARGE RIBOSOMAL SUBUNIT PROTEIN ML43 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrial large ribosomal subunit#GO:0005762;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;organellar ribosome#GO:0000313;protein-containing complex#GO:0032991;large ribosomal subunit#GO:0015934;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840;mitochondrial protein-containing complex#GO:0098798 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG182455|UniProtKB=T1FI80 T1FI80 20208529 PTHR48034:SF6 TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED TRANSFORMER-2 SEX-DETERMINING PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 positive regulation of gene expression#GO:0010628;positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of mRNA metabolic process#GO:1903313;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of mRNA processing#GO:0050684;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule biosynthetic process#GO:0010556;regulation of mRNA splicing, via spliceosome#GO:0048024;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG63814|UniProtKB=T1FXK7 T1FXK7 20213555 PTHR12241:SF145 TUBULIN POLYGLUTAMYLASE TUBULIN POLYGLUTAMYLASE TTLL5 cytoskeletal protein binding#GO:0008092;ligase activity#GO:0016874;protein binding#GO:0005515;tubulin binding#GO:0015631;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;microtubule cytoskeleton organization#GO:0000226;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;cellular component organization#GO:0016043;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;nitrogen compound metabolic process#GO:0006807;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;cilium#GO:0005929;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG170648|UniProtKB=T1F3A1 T1F3A1 20203300 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG105717|UniProtKB=T1EDX2 T1EDX2 20194774 PTHR23114:SF17 M7GPPPN-MRNA HYDROLASE M7GPPPN-MRNA HYDROLASE cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG62947|UniProtKB=T1FX82 T1FX82 20213430 PTHR11885:SF6 RIBOSOMAL PROTEIN S15P/S13E SMALL RIBOSOMAL SUBUNIT PROTEIN US15 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159;rRNA binding#GO:0019843 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;small ribosomal subunit#GO:0015935;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG187007|UniProtKB=T1FP55 T1FP55 20210602 PTHR11629:SF63 VACUOLAR PROTON ATPASES V-TYPE PROTON ATPASE SUBUNIT A enzyme binding#GO:0019899;protein binding#GO:0005515;binding#GO:0005488 regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;regulation of biological quality#GO:0065008;intracellular monoatomic cation homeostasis#GO:0030003;biological regulation#GO:0065007;intracellular pH reduction#GO:0051452;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic ion homeostasis#GO:0006873;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;vacuolar acidification#GO:0007035;regulation of cellular pH#GO:0030641;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;vacuolar membrane#GO:0005774;ATPase complex#GO:1904949;vacuole#GO:0005773;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;proton-transporting two-sector ATPase complex#GO:0016469;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG169608|UniProtKB=T1F258 T1F258 20202908 PTHR15708:SF4 ACTIN BUNDLING/MISSING IN METASTASIS-RELATED FI21477P1-RELATED cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;lipid binding#GO:0008289;phospholipid binding#GO:0005543;actin binding#GO:0003779;binding#GO:0005488 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cell projection organization#GO:0030030;membrane organization#GO:0061024;cellular component organization#GO:0016043;cellular process#GO:0009987;cell projection assembly#GO:0030031 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;side of membrane#GO:0098552;cytoplasmic side of plasma membrane#GO:0009898;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG173429|UniProtKB=T1F6T5 T1F6T5 20204534 PTHR13491:SF0 ZCCHC10 PROTEIN ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10 HELRO|EnsemblGenome=HelroG174963|UniProtKB=T1F8N5 T1F8N5 20205184 PTHR19325:SF574 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING SUSHI, VON WILLEBRAND FACTOR TYPE A, EGF AND PENTRAXIN DOMAIN-CONTAINING PROTEIN 1 complement component#PC00078 HELRO|EnsemblGenome=HelroG97089|UniProtKB=T1G9F3 T1G9F3 20217700 PTHR48101:SF4 METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED METHYLMALONYL-COA MUTASE, MITOCHONDRIAL small molecule binding#GO:0036094;intramolecular transferase activity#GO:0016866;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;heterocyclic compound binding#GO:1901363;tetrapyrrole binding#GO:0046906;isomerase activity#GO:0016853 lipid metabolic process#GO:0006629;oxoacid metabolic process#GO:0043436;fatty acid metabolic process#GO:0006631;cellular metabolic process#GO:0044237;cellular process#GO:0009987;cellular lipid metabolic process#GO:0044255;organic acid metabolic process#GO:0006082;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 mutase#PC00160 Methylmalonyl pathway#P02755>Methylmalonyl-CoA mutase#P03034;Succinate to proprionate conversion#P02777>Methylmalonyl-CoA mutase#P03161 HELRO|EnsemblGenome=HelroG163228|UniProtKB=T1ETT4 T1ETT4 20199984 PTHR10155:SF5 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT SUPPRESSOR OF CYTOKINE SIGNALING 7 enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;phosphatidylinositol 3-kinase complex#GO:0005942;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;membrane#GO:0016020;transferase complex, transferring phosphorus-containing groups#GO:0061695;extrinsic component of membrane#GO:0019898 kinase modulator#PC00140 Interferon-gamma signaling pathway#P00035>SOCS#P00956;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>SOCS#P00879 HELRO|EnsemblGenome=HelroG166802|UniProtKB=T1EYJ7 T1EYJ7 20201647 PTHR33395:SF21 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED PERICARDIN heart morphogenesis#GO:0003007;system development#GO:0048731;heart development#GO:0007507;circulatory system development#GO:0072359;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;animal organ development#GO:0048513;multicellular organism development#GO:0007275;developmental process#GO:0032502;animal organ morphogenesis#GO:0009887;multicellular organismal process#GO:0032501;cell adhesion#GO:0007155;cellular process#GO:0009987;post-embryonic development#GO:0009791 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG185707|UniProtKB=T1FN63 T1FN63 20210261 PTHR11599:SF14 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT ALPHA TYPE-5 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 peptidase complex#GO:1905368;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;proteasome complex#GO:0000502;endopeptidase complex#GO:1905369;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protease#PC00190;protein modifying enzyme#PC00260 Parkinson disease#P00049>20S proteasome#P01227 HELRO|EnsemblGenome=HelroG172655|UniProtKB=T1F5Q7 T1F5Q7 20204156 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG79366|UniProtKB=T1G3N2 T1G3N2 20215680 PTHR11472:SF34 DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER REGULATOR OF TELOMERE ELONGATION HELICASE 1 catalytic activity, acting on a nucleic acid#GO:0140640;ATP-dependent activity, acting on DNA#GO:0008094;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824 DNA helicase#PC00011;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG62194|UniProtKB=T1FWW8 T1FWW8 20213316 PTHR23147:SF68 SERINE/ARGININE RICH SPLICING FACTOR SPLICING FACTOR, ARGININE_SERINE-RICH 2-RELATED nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;nuclear speck#GO:0016607;organelle#GO:0043226;nuclear body#GO:0016604;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG74022|UniProtKB=T1G1L3 T1G1L3 20214961 PTHR16515:SF66 PR DOMAIN ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG185790|UniProtKB=T1FNA4 T1FNA4 20210301 PTHR46016:SF1 ZINC FINGER, RING/FYVE/PHD-TYPE RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 HELRO|EnsemblGenome=HelroG183836|UniProtKB=T1FK91 T1FK91 20209240 PTHR13628:SF1 TRANSMEMBRANE PROTEIN 267 TRANSMEMBRANE PROTEIN 267 HELRO|EnsemblGenome=HelroG72015|UniProtKB=T1G0U1 T1G0U1 20214689 PTHR24044:SF502 NOTCH LIGAND FAMILY MEMBER ANTERIOR PHARYNX IN EXCESS PROTEIN 1-RELATED protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG194459|UniProtKB=T1FW28 T1FW28 20213024 PTHR46117:SF3 FI24210P1 FI24210P1 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG167539|UniProtKB=T1EZG8 T1EZG8 20201968 PTHR15492:SF1 CYCLIN D1-BINDING PROTEIN 1 CYCLIN-D1-BINDING PROTEIN 1 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG114057|UniProtKB=T1EFY5 T1EFY5 20195487 PTHR23077:SF194 AAA-FAMILY ATPASE ATPASE FAMILY GENE 2 PROTEIN HOMOLOG B pyrophosphatase activity#GO:0016462;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;ATP hydrolysis activity#GO:0016887;ribonucleoside triphosphate phosphatase activity#GO:0017111;modification-dependent protein binding#GO:0140030;polyubiquitin modification-dependent protein binding#GO:0031593 cellular localization#GO:0051641;mitotic spindle organization#GO:0007052;macroautophagy#GO:0016236;macromolecule localization#GO:0033036;transport#GO:0006810;cell cycle process#GO:0022402;protein catabolic process#GO:0030163;microtubule cytoskeleton organization#GO:0000226;nitrogen compound transport#GO:0071705;organonitrogen compound catabolic process#GO:1901565;microtubule cytoskeleton organization involved in mitosis#GO:1902850;mitotic cell cycle process#GO:1903047;establishment of protein localization#GO:0045184;process utilizing autophagic mechanism#GO:0061919;organic substance transport#GO:0071702;mitotic cell cycle#GO:0000278;cellular component disassembly#GO:0022411;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;cytoskeleton organization#GO:0007010;spindle organization#GO:0007051;proteasomal protein catabolic process#GO:0010498;autophagosome maturation#GO:0097352;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;response to organic substance#GO:0010033;macromolecule catabolic process#GO:0009057;cellular response to stimulus#GO:0051716;protein-containing complex disassembly#GO:0032984;response to endoplasmic reticulum stress#GO:0034976;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;ERAD pathway#GO:0036503;response to organonitrogen compound#GO:0010243;cellular component organization#GO:0016043;cellular process#GO:0009987;organelle disassembly#GO:1903008;primary metabolic process#GO:0044238;protein localization#GO:0008104;localization#GO:0051179;response to nitrogen compound#GO:1901698;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;cellular macromolecule localization#GO:0070727;response to stress#GO:0006950;microtubule-based process#GO:0007017;response to chemical#GO:0042221;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;protein transport#GO:0015031;cell cycle#GO:0007049;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular response to stress#GO:0033554;autophagy#GO:0006914 membrane protein complex#GO:0098796;endoplasmic reticulum protein-containing complex#GO:0140534;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;cytosol#GO:0005829;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG181964|UniProtKB=T1FHJ0 T1FHJ0 20208289 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG73885|UniProtKB=T1G1K1 T1G1K1 20214949 PTHR44019:SF8 WD REPEAT-CONTAINING PROTEIN 55 POC1 CENTRIOLAR PROTEIN HOMOLOG cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG190088|UniProtKB=T1FRP1 T1FRP1 20211488 PTHR15351:SF3 ERLIN (ER LIPID RAFT ASSOCIATED PROTEIN) HOMOLOG ERLIN small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;steroid binding#GO:0005496;sterol binding#GO:0032934;lipid binding#GO:0008289;alcohol binding#GO:0043178;cholesterol binding#GO:0015485 regulation of biological process#GO:0050789;SREBP signaling pathway#GO:0032933;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;response to stress#GO:0006950;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular response to stress#GO:0033554;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG168509|UniProtKB=T1F0N3 T1F0N3 20202383 PTHR45665:SF9 AQUAPORIN-8 AQUAPORIN-8 inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;channel activity#GO:0015267;water transmembrane transporter activity#GO:0005372 localization#GO:0051179;water transport#GO:0006833;establishment of localization#GO:0051234;fluid transport#GO:0042044;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG109405|UniProtKB=T1EET5 T1EET5 20195087 PTHR11909:SF155 CASEIN KINASE-RELATED GILGAMESH, ISOFORM L transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 signal transduction#GO:0007165;macromolecule modification#GO:0043412;transport#GO:0006810;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;endocytosis#GO:0006897;cellular metabolic process#GO:0044237;vesicle-mediated transport#GO:0016192;organonitrogen compound metabolic process#GO:1901564;protein phosphorylation#GO:0006468;cell communication#GO:0007154;cellular process#GO:0009987;primary metabolic process#GO:0044238;localization#GO:0051179;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;import into cell#GO:0098657 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Parkinson disease#P00049>Casein kinase I#P01242 HELRO|EnsemblGenome=HelroG182820|UniProtKB=T1FIT0 T1FIT0 20208729 PTHR10075:SF100 BASIGIN RELATED FASCICLIN-2 cell adhesion molecule binding#GO:0050839;cell-cell adhesion mediator activity#GO:0098632;protein binding#GO:0005515;binding#GO:0005488 neuron projection guidance#GO:0097485;cell recognition#GO:0008037;neurogenesis#GO:0022008;cell projection organization#GO:0030030;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;axonogenesis#GO:0007409;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156;cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cell morphogenesis#GO:0000902;cellular process#GO:0009987;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure development#GO:0048856;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;axon#GO:0030424 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG67993|UniProtKB=T1FZ91 T1FZ91 20214139 PTHR12233:SF2 VACUOLAR PROTEIN SORTING 26 RELATED VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 26C localization#GO:0051179;organic substance transport#GO:0071702;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;protein transport#GO:0015031;nitrogen compound transport#GO:0071705;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG184217|UniProtKB=T1FKS5 T1FKS5 20209424 PTHR43250:SF2 EXODEOXYRIBONUCLEASE III EXODEOXYRIBONUCLEASE III HELRO|EnsemblGenome=HelroG188363|UniProtKB=T1FPX3 T1FPX3 20210870 PTHR16008:SF6 F-BOX ONLY PROTEIN 4 SI:DKEY-12E7.1 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234 HELRO|EnsemblGenome=HelroG159892|UniProtKB=T1EPI3 T1EPI3 20198483 PTHR45698:SF1 TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG86753|UniProtKB=T1G6G5 T1G6G5 20216662 PTHR24033:SF193 EGF-LIKE DOMAIN-CONTAINING PROTEIN NETRIN-G1-RELATED Axon guidance mediated by netrin#P00009>Netrin#P00357;Axon guidance mediated by Slit/Robo#P00008>Netrin#P00344 HELRO|EnsemblGenome=HelroG80019|UniProtKB=T1G3W6 T1G3W6 20215764 PTHR16074:SF4 BARDET-BIEDL SYNDROME 7 PROTEIN BARDET-BIEDL SYNDROME 7 PROTEIN cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;cilium assembly#GO:0060271;cell projection organization#GO:0030030;macromolecule localization#GO:0033036;transport#GO:0006810;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;protein localization#GO:0008104;localization#GO:0051179;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;plasma membrane bounded cell projection assembly#GO:0120031 axoneme#GO:0005930;microtubule organizing center#GO:0005815;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;ciliary plasm#GO:0097014;plasma membrane bounded cell projection cytoplasm#GO:0032838;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cytoskeleton#GO:0005856;BBSome#GO:0034464;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG105479|UniProtKB=T1EDV4 T1EDV4 20194756 PTHR12714:SF9 PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG160471|UniProtKB=T1EQA5 T1EQA5 20198755 PTHR12461:SF100 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED JMJC DOMAIN-CONTAINING PROTEIN 4 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG193752|UniProtKB=T1FVB5 T1FVB5 20212761 PTHR11893:SF36 INNEXIN INNEXIN-5 cell junction protein#PC00070;gap junction#PC00105 HELRO|EnsemblGenome=HelroG162425|UniProtKB=T1ESM9 T1ESM9 20199579 PTHR11686:SF9 GAMMA GLUTAMYL TRANSPEPTIDASE RE13973P hydrolase activity#GO:0016787;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 sulfur compound metabolic process#GO:0006790;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;peptide catabolic process#GO:0043171;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;cellular process#GO:0009987;glutathione metabolic process#GO:0006749;sulfur compound catabolic process#GO:0044273;nitrogen compound metabolic process#GO:0006807;cellular modified amino acid metabolic process#GO:0006575;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG99753|UniProtKB=T1G9V0 T1G9V0 20217846 PTHR19878:SF8 AUTOPHAGY PROTEIN 16-LIKE AUTOPHAGY-RELATED 16, ISOFORM F HELRO|EnsemblGenome=HelroG179321|UniProtKB=T1FEJ5 T1FEJ5 20207244 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158526|UniProtKB=T1EMW9 T1EMW9 20197919 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG194060|UniProtKB=T1FVM7 T1FVM7 20212873 PTHR24133:SF33 ANKYRIN DOMAIN-CONTAINING ANKYRIN, ISOFORM B cytoskeletal protein binding#GO:0008092;molecular adaptor activity#GO:0060090;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;transmembrane transporter binding#GO:0044325;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674 localization#GO:0051179;protein localization to plasma membrane#GO:0072659;protein localization to cell periphery#GO:1990778;localization within membrane#GO:0051668;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;cellular process#GO:0009987;protein localization#GO:0008104 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;neuron projection#GO:0043005;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG182008|UniProtKB=T1FHL1 T1FHL1 20208310 PTHR19282:SF515 TETRASPANIN TETRASPANIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG182949|UniProtKB=T1FIY9 T1FIY9 20208788 PTHR10656:SF42 CELL FATE DETERMINING PROTEIN MAB21-RELATED CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED transferase#PC00220;nucleotidyltransferase#PC00174;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG182635|UniProtKB=T1FII6 T1FII6 20208635 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG166703|UniProtKB=T1EYE3 T1EYE3 20201593 PTHR23412:SF17 STEREOCILIN RELATED OTOANCORIN cell adhesion#GO:0007155;cellular process#GO:0009987;cell-substrate adhesion#GO:0031589;cell-matrix adhesion#GO:0007160 cell surface#GO:0009986;cellular anatomical entity#GO:0110165 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG105890|UniProtKB=T1EDY3 T1EDY3 20194785 PTHR42908:SF6 TRANSLATION ELONGATION FACTOR-RELATED 116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT GTPase activity#GO:0003924;nucleic acid binding#GO:0003676;binding#GO:0005488;catalytic activity#GO:0003824;snRNA binding#GO:0017069;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;translation regulator activity#GO:0045182;RNA binding#GO:0003723;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;translation regulator activity, nucleic acid binding#GO:0090079;translation elongation factor activity#GO:0003746;translation factor activity, RNA binding#GO:0008135 cellular aromatic compound metabolic process#GO:0006725;RNA metabolic process#GO:0016070;peptide metabolic process#GO:0006518;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;translation#GO:0006412;organic cyclic compound metabolic process#GO:1901360;mRNA metabolic process#GO:0016071;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;translational elongation#GO:0006414 catalytic step 2 spliceosome#GO:0071013;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;U4/U6 x U5 tri-snRNP complex#GO:0046540;cytosol#GO:0005829;U2-type spliceosomal complex#GO:0005684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;spliceosomal tri-snRNP complex#GO:0097526;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 translation elongation factor#PC00222 HELRO|EnsemblGenome=HelroG111906|UniProtKB=T1EFF6 T1EFF6 20195308 PTHR33562:SF31 ATILLA, ISOFORM B-RELATED-RELATED PROTEIN QUIVER HELRO|EnsemblGenome=HelroG68730|UniProtKB=T1FZJ0 T1FZJ0 20214238 PTHR48041:SF78 ABC TRANSPORTER G FAMILY MEMBER 28 ABC TRANSPORTER EXPRESSED IN TRACHEA, ISOFORM A transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG178544|UniProtKB=T1FDC4 T1FDC4 20206823 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG194594|UniProtKB=T1FW85 T1FW85 20213081 PTHR16021:SF23 MANSC DOMAIN CONTAINING PROTEIN 1 FI18411P1-RELATED HELRO|EnsemblGenome=HelroG194579|UniProtKB=T1FW77 T1FW77 20213073 PTHR12374:SF63 TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED TRANSCRIPTIONAL ADAPTER 2-BETA molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;binding#GO:0005488;chromatin binding#GO:0003682;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;protein-containing complex binding#GO:0044877 protein-DNA complex organization#GO:0071824;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;cellular component organization#GO:0016043;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 SAGA-type complex#GO:0070461;histone acetyltransferase complex#GO:0000123;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;acetyltransferase complex#GO:1902493;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG173384|UniProtKB=T1F6R3 T1F6R3 20204512 PTHR14647:SF87 GALACTOSE-3-O-SULFOTRANSFERASE PUTATIVE-RELATED transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG163489|UniProtKB=T1EU44 T1EU44 20200094 PTHR19307:SF14 TUMOR PROTEIN D52 TUMOR PROTEIN D52 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG105574|UniProtKB=T1EDW3 T1EDW3 20194765 PTHR10253:SF5 POLYCOMB PROTEIN POLYCOMB PROTEIN EED nucleosome binding#GO:0031491;protein-containing complex binding#GO:0044877;chromatin binding#GO:0003682;binding#GO:0005488 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;protein-DNA complex organization#GO:0071824;negative regulation of RNA metabolic process#GO:0051253;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;regulation of transcription by RNA polymerase II#GO:0006357;heterochromatin formation#GO:0031507;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;regulation of DNA-templated transcription#GO:0006355;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;negative regulation of gene expression, epigenetic#GO:0045814;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;epigenetic regulation of gene expression#GO:0040029;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;heterochromatin organization#GO:0070828;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;chromatin organization#GO:0006325;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;histone methyltransferase complex#GO:0035097;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nucleoplasm#GO:0005654;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;methyltransferase complex#GO:0034708;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;PcG protein complex#GO:0031519;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG79030|UniProtKB=T1G3I8 T1G3I8 20215636 PTHR12027:SF70 WNT RELATED PROTEIN WNT-16 molecular function activator activity#GO:0140677;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;protein binding#GO:0005515;cytokine activity#GO:0005125;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;neurogenesis#GO:0022008;developmental process#GO:0032502;multicellular organism development#GO:0007275;cell communication#GO:0007154;cell fate commitment#GO:0045165;cell-cell signaling by wnt#GO:0198738;nervous system development#GO:0007399;cellular process#GO:0009987;regulation of biological process#GO:0050789;system development#GO:0048731;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;cell-cell signaling#GO:0007267;signaling#GO:0023052;canonical Wnt signaling pathway#GO:0060070;Wnt signaling pathway#GO:0016055 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Cadherin signaling pathway#P00012>Wnt#P00474 HELRO|EnsemblGenome=HelroG183156|UniProtKB=T1FJ82 T1FJ82 20208881 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG174318|UniProtKB=T1F7Z7 T1F7Z7 20204946 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175348|UniProtKB=T1F964 T1F964 20205363 PTHR45888:SF5 HL01030P-RELATED D4, ISOFORM A HELRO|EnsemblGenome=HelroG78249|UniProtKB=T1G397 T1G397 20215545 PTHR11202:SF22 SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER PROTEIN ENABLED scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG175903|UniProtKB=T1F9U9 T1F9U9 20205598 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165647|UniProtKB=T1EX44 T1EX44 20201144 PTHR46601:SF1 ULP_PROTEASE DOMAIN-CONTAINING PROTEIN ADF-H DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG99297|UniProtKB=T1G9S0 T1G9S0 20217816 PTHR11375:SF0 ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER A protein binding#GO:0005515;binding#GO:0005488;histone binding#GO:0042393 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG145221|UniProtKB=T1EJJ3 T1EJJ3 20196743 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG65297|UniProtKB=T1FY57 T1FY57 20213755 PTHR47634:SF9 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;macromolecule modification#GO:0043412;regulation of nitrogen compound metabolic process#GO:0051171;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of mRNA processing#GO:0050684;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;protein phosphorylation#GO:0006468;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;biological regulation#GO:0065007;mRNA processing#GO:0006397;peptidyl-serine modification#GO:0018209;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375;spliceosomal complex assembly#GO:0000245;regulation of metabolic process#GO:0019222;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323 HELRO|EnsemblGenome=HelroG157599|UniProtKB=T1EMD7 T1EMD7 20197737 PTHR48033:SF9 RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN TAR DNA-BINDING PROTEIN 43 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG95956|UniProtKB=T1G991 T1G991 20217638 PTHR42693:SF47 ARYLSULFATASE FAMILY MEMBER N-ACETYLGALACTOSAMINE-6-SULFATASE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG163505|UniProtKB=T1EU52 T1EU52 20200102 PTHR45828:SF33 CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE DOMON DOMAIN-CONTAINING PROTEIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 reductase#PC00198;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG192781|UniProtKB=T1FUA1 T1FUA1 20212397 PTHR10068:SF14 BONE MARROW PROTEOGLYCAN CELL WALL ADHESIN EAP1 extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG170649|UniProtKB=T1F3A2 T1F3A2 20203301 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-LIKE 1 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;localization#GO:0051179;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 membrane protein complex#GO:0098796;synapse#GO:0045202;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron projection#GO:0043005;transmembrane transporter complex#GO:1902495;cell projection#GO:0042995;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HELRO|EnsemblGenome=HelroG189127|UniProtKB=T1FQP6 T1FQP6 20211143 PTHR11101:SF80 PHOSPHATE TRANSPORTER PHOSPHATE TRANSPORTER inorganic molecular entity transmembrane transporter activity#GO:0015318;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;inorganic anion transmembrane transport#GO:0098661;phosphate ion transport#GO:0006817;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;inorganic anion transport#GO:0015698 transporter#PC00227 HELRO|EnsemblGenome=HelroG166004|UniProtKB=T1EXK6 T1EXK6 20201306 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG68894|UniProtKB=T1FZK8 T1FZK8 20214256 PTHR11802:SF3 SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171;carboxypeptidase activity#GO:0004180 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG139735|UniProtKB=T1EIZ4 T1EIZ4 20196544 PTHR45992:SF2 EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED EUKARYOTIC ELONGATION FACTOR 2 KINASE transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 response to organic substance#GO:0010033;response to organic cyclic compound#GO:0014070;protein-containing complex disassembly#GO:0032984;response to oxygen-containing compound#GO:1901700;cellular component organization#GO:0016043;cellular process#GO:0009987;response to stimulus#GO:0050896;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;cellular component disassembly#GO:0022411;response to chemical#GO:0042221;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036 Oxidative stress response#P00046>eEF2K#P01127;p38 MAPK pathway#P05918>eEF2K#P06022 HELRO|EnsemblGenome=HelroG82671|UniProtKB=T1G4V1 T1G4V1 20216099 PTHR46154:SF4 FAMILY NOT NAMED UREA ACTIVE TRANSPORTER HELRO|EnsemblGenome=HelroG104040|UniProtKB=T1EDJ3 T1EDJ3 20194645 PTHR10974:SF1 FI08016P-RELATED FI08016P-RELATED extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 HELRO|EnsemblGenome=HelroG184374|UniProtKB=T1FL29 T1FL29 20209528 PTHR47160:SF10 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG66814|UniProtKB=T1FYR3 T1FYR3 20213961 PTHR11003:SF334 POTASSIUM CHANNEL, SUBFAMILY K FI03418P monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG181006|UniProtKB=T1FGI6 T1FGI6 20207935 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG113378|UniProtKB=T1EFS1 T1EFS1 20195423 PTHR12731:SF1 TRANSLOCON-ASSOCIATED PROTEIN, DELTA SUBUNIT TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT DELTA cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG159763|UniProtKB=T1EPD7 T1EPD7 20198437 PTHR12264:SF21 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12 protein binding#GO:0005515;nucleic acid binding#GO:0003676;transcription factor binding#GO:0008134;binding#GO:0005488;organic cyclic compound binding#GO:0097159;TBP-class protein binding#GO:0017025;DNA binding#GO:0003677 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;RNA metabolic process#GO:0016070;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;RNA polymerase II preinitiation complex assembly#GO:0051123;transcription initiation at RNA polymerase II promoter#GO:0006367;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;DNA-directed RNA polymerase complex#GO:0000428;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nucleoplasm#GO:0005654;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;transcription factor TFIID complex#GO:0005669;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;transcription regulator complex#GO:0005667;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 general transcription factor#PC00259 General transcription regulation#P00023>TBP-associated factors#P00658;Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385 HELRO|EnsemblGenome=HelroG104068|UniProtKB=T1EDJ4 T1EDJ4 20194646 PTHR12913:SF1 UNR PROTEIN N-RAS UPSTREAM GENE PROTEIN COLD SHOCK DOMAIN-CONTAINING PROTEIN E1 HELRO|EnsemblGenome=HelroG106963|UniProtKB=T1EE63 T1EE63 20194865 PTHR10110:SF98 SODIUM/HYDROGEN EXCHANGER SODIUM_HYDROGEN EXCHANGER secondary active transmembrane transporter activity#GO:0015291;inorganic molecular entity transmembrane transporter activity#GO:0015318;antiporter activity#GO:0015297;transmembrane transporter activity#GO:0022857;potassium ion transmembrane transporter activity#GO:0015079;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;proton transmembrane transporter activity#GO:0015078;metal cation:proton antiporter activity#GO:0051139;active monoatomic ion transmembrane transporter activity#GO:0022853;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;inorganic cation transmembrane transporter activity#GO:0022890;transporter activity#GO:0005215 regulation of intracellular pH#GO:0051453;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;regulation of pH#GO:0006885;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;regulation of cellular pH#GO:0030641;import into cell#GO:0098657;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG172935|UniProtKB=T1F659 T1F659 20204308 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG95556|UniProtKB=T1G968 T1G968 20217615 PTHR13148:SF0 PER1-RELATED POST-GPI ATTACHMENT TO PROTEINS FACTOR 3 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;phospholipid biosynthetic process#GO:0008654;macromolecule modification#GO:0043412;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycolipid metabolic process#GO:0006664;protein modification process#GO:0036211;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;glycerolipid biosynthetic process#GO:0045017;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;organic substance biosynthetic process#GO:1901576;liposaccharide metabolic process#GO:1903509;cellular process#GO:0009987;GPI anchor metabolic process#GO:0006505;membrane lipid biosynthetic process#GO:0046467;lipoprotein biosynthetic process#GO:0042158;primary metabolic process#GO:0044238;GPI anchor biosynthetic process#GO:0006506;carbohydrate derivative biosynthetic process#GO:1901137;membrane lipid metabolic process#GO:0006643;glycerophospholipid biosynthetic process#GO:0046474;glycolipid biosynthetic process#GO:0009247;organophosphate metabolic process#GO:0019637;lipoprotein metabolic process#GO:0042157;cellular lipid metabolic process#GO:0044255 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG166823|UniProtKB=T1EYK7 T1EYK7 20201657 PTHR22677:SF4 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 60 USHER SYNDROME TYPE-1G PROTEIN-LIKE PROTEIN HELRO|EnsemblGenome=HelroG188397|UniProtKB=T1FPY1 T1FPY1 20210878 PTHR13800:SF1 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPM monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic cation transport#GO:0006812;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG191647|UniProtKB=T1FT62 T1FT62 20212009 PTHR11040:SF140 ZINC/IRON TRANSPORTER ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;transition metal ion transport#GO:0000041;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG177502|UniProtKB=T1FBT4 T1FBT4 20206283 PTHR33562:SF28 ATILLA, ISOFORM B-RELATED-RELATED PROTEIN QUIVER HELRO|EnsemblGenome=HelroG172609|UniProtKB=T1F5M2 T1F5M2 20204121 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG187040|UniProtKB=T1FP59 T1FP59 20210606 PTHR13465:SF2 UPF0183 PROTEIN PHAGOSOME ASSEMBLY FACTOR 1 HELRO|EnsemblGenome=HelroG159370|UniProtKB=T1ENY5 T1ENY5 20198285 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG154346|UniProtKB=T1ELE5 T1ELE5 20197395 PTHR11889:SF31 HEDGEHOG PROTEIN HEDGEHOG intercellular signal molecule#PC00207 Hedgehog signaling pathway#P00025>Hedgehog#P00688 HELRO|EnsemblGenome=HelroG73137|UniProtKB=T1G1A7 T1G1A7 20214855 PTHR47992:SF119 PROTEIN PHOSPHATASE PROTEIN PHOSPHATASE 1K, MITOCHONDRIAL hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;dephosphorylation#GO:0016311;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG68435|UniProtKB=T1FZE7 T1FZE7 20214195 PTHR18952:SF208 CARBONIC ANHYDRASE CARBONIC ANHYDRASE XA-RELATED carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 cellular metabolic process#GO:0044237;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG71126|UniProtKB=T1G0G9 T1G0G9 20214567 PTHR24388:SF53 ZINC FINGER PROTEIN CHORION TRANSCRIPTION FACTOR CF2-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG91608|UniProtKB=T1G860 T1G860 20217257 PTHR21297:SF0 DNA-DIRECTED RNA POLYMERASE II DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB4 protein binding#GO:0005515;translation initiation factor binding#GO:0031369;binding#GO:0005488 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;transcription initiation at RNA polymerase II promoter#GO:0006367;mRNA 3'-end processing#GO:0031124;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;aromatic compound biosynthetic process#GO:0019438;protein-RNA complex organization#GO:0071826;transcription by RNA polymerase II#GO:0006366 membrane-enclosed lumen#GO:0031974;RNA polymerase II, core complex#GO:0005665;organelle lumen#GO:0043233;nucleus#GO:0005634;DNA-directed RNA polymerase complex#GO:0000428;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nucleoplasm#GO:0005654;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388;General transcription regulation#P00023>RNA Polymerase II#P00660 HELRO|EnsemblGenome=HelroG100875|UniProtKB=T1ED18 T1ED18 20194470 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG189280|UniProtKB=T1FQW9 T1FQW9 20211216 PTHR14523:SF1 UNCHARACTERIZED PROTEIN C17ORF53 HOMOLOG HOMOLOGOUS RECOMBINATION OB-FOLD PROTEIN HELRO|EnsemblGenome=HelroG115175|UniProtKB=T1EG70 T1EG70 20195572 PTHR24043:SF8 SCAVENGER RECEPTOR CLASS F EGF-LIKE DOMAIN-CONTAINING PROTEIN membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG114382|UniProtKB=T1EG12 T1EG12 20195514 PTHR10627:SF31 SCP160 DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG171945|UniProtKB=T1F4V7 T1F4V7 20203856 PTHR11690:SF300 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET PROTEIN 19 monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG77287|UniProtKB=T1G2V8 T1G2V8 20215406 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG186886|UniProtKB=T1FP44 T1FP44 20210591 PTHR24418:SF373 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE SRC42A protein tyrosine kinase activity#GO:0004713;non-membrane spanning protein tyrosine kinase activity#GO:0004715;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein binding#GO:0005515;catalytic activity, acting on a protein#GO:0140096;signaling receptor binding#GO:0005102;kinase activity#GO:0016301;protein kinase activity#GO:0004672 response to external biotic stimulus#GO:0043207;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;immune response#GO:0006955;developmental process#GO:0032502;cell communication#GO:0007154;cellular process#GO:0009987;defense response to symbiont#GO:0140546;regulation of biological process#GO:0050789;immune system process#GO:0002376;response to stimulus#GO:0050896;response to external stimulus#GO:0009605;cell differentiation#GO:0030154;enzyme-linked receptor protein signaling pathway#GO:0007167;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to other organism#GO:0098542;regulation of cellular process#GO:0050794;response to other organism#GO:0051707;cell surface receptor signaling pathway#GO:0007166;biological process involved in interspecies interaction between organisms#GO:0044419;biological regulation#GO:0065007;innate immune response#GO:0045087;defense response#GO:0006952;signaling#GO:0023052;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169 non-receptor tyrosine protein kinase#PC00168 Parkinson disease#P00049>Src kinase#P01230;Integrin signalling pathway#P00034>Src#P00940 HELRO|EnsemblGenome=HelroG153387|UniProtKB=T1EL63 T1EL63 20197313 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192056|UniProtKB=T1FTJ8 T1FTJ8 20212145 PTHR21711:SF0 MITOCHONDRIAL INNER MEMBRANE PROTEASE MITOCHONDRIAL INNER MEMBRANE PROTEASE ATP23 HOMOLOG cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;mitochondrial protein processing#GO:0034982;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein-containing complex assembly#GO:0065003;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nitrogen compound metabolic process#GO:0006807;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;proteolysis#GO:0006508;mitochondrial proton-transporting ATP synthase complex assembly#GO:0033615;mitochondrion organization#GO:0007005;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG172179|UniProtKB=T1F547 T1F547 20203946 PTHR15544:SF0 OSMOSIS RESPONSIVE FACTOR TETRATRICOPEPTIDE REPEAT PROTEIN 33 HELRO|EnsemblGenome=HelroG170208|UniProtKB=T1F2S7 T1F2S7 20203126 PTHR14952:SF9 ROPPORIN-1-LIKE PROTEIN EF-HAND DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG74186|UniProtKB=T1G1N2 T1G1N2 20214980 PTHR24348:SF64 SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED SERINE_THREONINE-PROTEIN KINASE DDB_G0278901-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;peptidyl-amino acid modification#GO:0018193;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;nitrogen compound metabolic process#GO:0006807;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG131017|UniProtKB=T1EHV0 T1EHV0 20196150 PTHR24346:SF42 MAP/MICROTUBULE AFFINITY-REGULATING KINASE SERINE_THREONINE-PROTEIN KINASE SIK3 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;microtubule cytoskeleton organization#GO:0000226;cell communication#GO:0007154;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;regulation of cellular process#GO:0050794;organelle organization#GO:0006996;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;intracellular signal transduction#GO:0035556;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG111248|UniProtKB=T1EF98 T1EF98 20195250 PTHR11630:SF47 DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER DNA HELICASE MCM8 ATP-dependent activity, acting on DNA#GO:0008094;nucleic acid binding#GO:0003676;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;single-stranded DNA binding#GO:0003697;DNA binding#GO:0003677;catalytic activity, acting on a nucleic acid#GO:0140640;DNA helicase activity#GO:0003678;single-stranded DNA helicase activity#GO:0017116;catalytic activity, acting on DNA#GO:0140097 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;MCM complex#GO:0042555;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG68493|UniProtKB=T1FZF7 T1FZF7 20214205 PTHR22760:SF2 GLYCOSYLTRANSFERASE ALPHA-1,2-MANNOSYLTRANSFERASE ALG9 mannosyltransferase activity#GO:0000030;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG65481|UniProtKB=T1FY83 T1FY83 20213781 PTHR22603:SF93 CHOLINE/ETHANOALAMINE KINASE RE24176P transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;glycerolipid biosynthetic process#GO:0045017;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;glycerophospholipid metabolic process#GO:0006650;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;phosphatidylcholine biosynthetic process#GO:0006656;glycerolipid metabolic process#GO:0046486;nitrogen compound metabolic process#GO:0006807;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;phosphatidylcholine metabolic process#GO:0046470;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 kinase#PC00137 HELRO|EnsemblGenome=HelroG149122|UniProtKB=T1EKC4 T1EKC4 20197024 PTHR12166:SF8 CALCIUM-DEPENDENT SECRETION ACTIVATOR CALCIUM-DEPENDENT SECRETION ACTIVATOR localization#GO:0051179;establishment of localization#GO:0051234;exocytosis#GO:0006887;secretion#GO:0046903;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;export from cell#GO:0140352;secretion by cell#GO:0032940 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG185611|UniProtKB=T1FN13 T1FN13 20210212 PTHR13116:SF5 ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3 ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein folding#GO:0006457;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane protein complex#GO:0098796;endoplasmic reticulum protein-containing complex#GO:0140534;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;EMC complex#GO:0072546;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG157076|UniProtKB=T1EM59 T1EM59 20197659 PTHR24223:SF454 ATP-BINDING CASSETTE SUB-FAMILY C SUBFAMILY NOT NAMED transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG101038|UniProtKB=T1ED27 T1ED27 20194479 PTHR45646:SF11 SERINE/THREONINE-PROTEIN KINASE DOA-RELATED SERINE_THREONINE-PROTEIN KINASE DOA transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG183218|UniProtKB=T1FJB9 T1FJB9 20208918 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG159284|UniProtKB=T1ENU2 T1ENU2 20198242 PTHR16216:SF2 DYNEIN ASSEMBLY FACTOR 5, AXONEMAL DYNEIN AXONEMAL ASSEMBLY FACTOR 5 chaperone#PC00072 HELRO|EnsemblGenome=HelroG64107|UniProtKB=T1FXP3 T1FXP3 20213591 PTHR13398:SF0 GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2 GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2 transferase activity#GO:0016740;fucosyltransferase activity#GO:0008417;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG92225|UniProtKB=T1G8D2 T1G8D2 20217329 PTHR19850:SF25 GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1 molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591;signaling receptor complex adaptor activity#GO:0030159;protein-macromolecule adaptor activity#GO:0030674 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;plasma membrane protein complex#GO:0098797;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;side of membrane#GO:0098552;cytoplasmic side of plasma membrane#GO:0009898;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;extrinsic component of membrane#GO:0019898 heterotrimeric G-protein#PC00117;G-protein#PC00020 5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;5HT4 type receptor mediated signaling pathway#P04376>G-protein#P04430;Histamine H2 receptor mediated signaling pathway#P04386>G-Protein#P04490;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;Beta1 adrenergic receptor signaling pathway#P04377>G-Protein#P04436;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Gbeta#P00710;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Opioid prodynorphin pathway#P05916>G-protein#P06002;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;Wnt signaling pathway#P00057>GBeta#P01457;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Enkephalin release#P05913>G-Protein (i)#P05974;PI3 kinase pathway#P00048>Gbetagamma#P01188;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Gbeta#P00727;Enkephalin release#P05913>G-Protein (s)#P05977;Opioid proenkephalin pathway#P05915>G-protein#P05994;Beta3 adrenergic receptor signaling pathway#P04379>G-Protein#P04448;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Beta2 adrenergic receptor signaling pathway#P04378>G-Protein#P04443;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Gbeta#P00753 HELRO|EnsemblGenome=HelroG85072|UniProtKB=T1G5S4 T1G5S4 20216421 PTHR45695:SF23 LEUCOKININ RECEPTOR-RELATED GALANIN-LIKE G-PROTEIN COUPLED RECEPTOR NPR-9 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG75835|UniProtKB=T1G2B0 T1G2B0 20215208 PTHR12878:SF0 NADH-UBIQUINONE OXIDOREDUCTASE B8 SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 2 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transporter complex#GO:1990351;oxidoreductase complex#GO:1990204;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;respirasome#GO:0070469;mitochondrial respiratory chain complex I#GO:0005747;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;transmembrane transporter complex#GO:1902495;mitochondrial respirasome#GO:0005746;membrane-bounded organelle#GO:0043227;respiratory chain complex I#GO:0045271;NADH dehydrogenase complex#GO:0030964;mitochondrial protein-containing complex#GO:0098798 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG81484|UniProtKB=T1G4F0 T1G4F0 20215948 PTHR24416:SF566 TYROSINE-PROTEIN KINASE RECEPTOR EPIDERMAL GROWTH FACTOR RECEPTOR signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 negative regulation of biological process#GO:0048519;signal transduction#GO:0007165;neurogenesis#GO:0022008;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;positive regulation of cell population proliferation#GO:0008284;regulation of catalytic activity#GO:0050790;nervous system development#GO:0007399;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;system development#GO:0048731;cell differentiation#GO:0030154;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;negative regulation of programmed cell death#GO:0043069;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;regulation of programmed cell death#GO:0043067;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;cellular developmental process#GO:0048869;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;regulation of apoptotic process#GO:0042981;regulation of cell population proliferation#GO:0042127;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;negative regulation of apoptotic process#GO:0043066;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;anatomical structure development#GO:0048856;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 basal plasma membrane#GO:0009925;receptor complex#GO:0043235;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;basal part of cell#GO:0045178;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 EGF receptor signaling pathway#P00018>EGFR#P00542;Cadherin signaling pathway#P00012>EGFR#P00466 HELRO|EnsemblGenome=HelroG159365|UniProtKB=T1ENY0 T1ENY0 20198280 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG84739|UniProtKB=T1G5M9 T1G5M9 20216376 PTHR15664:SF6 C20ORF30 PROTEIN TRANSMEMBRANE PROTEIN 230 cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG92299|UniProtKB=T1G8D9 T1G8D9 20217336 PTHR34593:SF13 MATING RESPONSE PROTEIN POI2 SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG64295|UniProtKB=T1FXS5 T1FXS5 20213623 PTHR24204:SF8 INSULIN GENE ENHANCER PROTEIN TAILUP, ISOFORM A cellular developmental process#GO:0048869;neurogenesis#GO:0022008;cell projection organization#GO:0030030;multicellular organism development#GO:0007275;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;cell morphogenesis#GO:0000902;cellular component organization#GO:0016043;cell fate commitment#GO:0045165;cellular process#GO:0009987;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;cell fate specification#GO:0001708;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;cell differentiation#GO:0030154;system development#GO:0048731;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;neuron differentiation#GO:0030182;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;axonogenesis#GO:0007409;plasma membrane bounded cell projection morphogenesis#GO:0120039;generation of neurons#GO:0048699 HELRO|EnsemblGenome=HelroG103742|UniProtKB=T1EDH2 T1EDH2 20194624 PTHR10799:SF964 SNF2/RAD54 HELICASE FAMILY SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A CONTAINING DEAD_H BOX 1 ATP-dependent activity, acting on DNA#GO:0008094;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on DNA#GO:0140097;protein-containing complex binding#GO:0044877 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;chromosome#GO:0005694;chromatin#GO:0000785;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA helicase#PC00011;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG192901|UniProtKB=T1FUE5 T1FUE5 20212441 PTHR10219:SF43 GLYCOLIPID TRANSFER PROTEIN-RELATED GLYCOLIPID TRANSFER PROTEIN DOMAIN-CONTAINING PROTEIN lipid transfer activity#GO:0120013;small molecule binding#GO:0036094;binding#GO:0005488;amide binding#GO:0033218;phospholipid transporter activity#GO:0005548;lipid binding#GO:0008289;ion binding#GO:0043167;anion binding#GO:0043168;phospholipid binding#GO:0005543;transporter activity#GO:0005215;lipid transporter activity#GO:0005319 amide transport#GO:0042886;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;membrane organization#GO:0061024;transport#GO:0006810;nitrogen compound transport#GO:0071705;cellular component organization#GO:0016043;lipid localization#GO:0010876;intermembrane lipid transfer#GO:0120009;cellular process#GO:0009987;lipid transport#GO:0006869 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG103156|UniProtKB=T1EDE5 T1EDE5 20194597 PTHR20930:SF0 OVARIAN CARCINOMA ANTIGEN CA125-RELATED PROTEIN ILRUN HELRO|EnsemblGenome=HelroG162194|UniProtKB=T1ESC3 T1ESC3 20199473 PTHR11829:SF142 FORKHEAD BOX PROTEIN FORK-HEAD DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;anatomical structure morphogenesis#GO:0009653;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG157004|UniProtKB=T1EM48 T1EM48 20197648 PTHR10369:SF3 60S RIBOSOMAL PROTEIN L36A/L44 RIBOSOMAL PROTEIN L36A LIKE cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG123324|UniProtKB=T1EGX5 T1EGX5 20195825 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG80799|UniProtKB=T1G457 T1G457 20215855 PTHR21136:SF179 SNARE PROTEINS VESICLE ASSOCIATED MEMBRANE PROTEIN 7-RELATED molecular adaptor activity#GO:0060090;protein binding#GO:0005515;SNAP receptor activity#GO:0005484;binding#GO:0005488;SNARE binding#GO:0000149;protein-macromolecule adaptor activity#GO:0030674 vesicle fusion#GO:0006906;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;membrane fusion#GO:0061025;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;organelle organization#GO:0006996;vesicle organization#GO:0016050;export from cell#GO:0140352;organelle fusion#GO:0048284;secretion by cell#GO:0032940 SNARE complex#GO:0031201;cytoplasm#GO:0005737;membrane protein complex#GO:0098796;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034 HELRO|EnsemblGenome=HelroG181809|UniProtKB=T1FHC9 T1FHC9 20208228 PTHR24314:SF20 NON-SPECIFIC LIPID TRANSFER PROTEIN-RELATED STEROL CARRIER PROTEIN 2 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG130122|UniProtKB=T1EHT2 T1EHT2 20196132 PTHR23304:SF192 SPOT2-RELATED SYNTAXIN-BINDING PROTEIN 2 HELRO|EnsemblGenome=HelroG192338|UniProtKB=T1FTU3 T1FTU3 20212240 PTHR23340:SF0 ARGININE/SERINE RICH SPLICING FACTOR SF4/14 SURP AND G-PATCH DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG110475|UniProtKB=T1EF25 T1EF25 20195177 PTHR24416:SF564 TYROSINE-PROTEIN KINASE RECEPTOR MACROPHAGE-STIMULATING PROTEIN RECEPTOR signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;nervous system development#GO:0007399;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;system development#GO:0048731;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cell motility#GO:0048870;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;cell migration#GO:0016477;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG172804|UniProtKB=T1F5Y5 T1F5Y5 20204234 PTHR10484:SF0 HISTONE H4 HISTONE H4 TYPE VIII nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;nucleosome organization#GO:0034728;nucleosome assembly#GO:0006334;protein-containing complex organization#GO:0043933;protein-containing complex assembly#GO:0065003;chromatin organization#GO:0006325;cellular component organization#GO:0016043;cellular process#GO:0009987;chromatin remodeling#GO:0006338;protein-DNA complex assembly#GO:0065004 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG179527|UniProtKB=T1FEU6 T1FEU6 20207345 PTHR23301:SF0 CHITIN BINDING PERITROPHIN-A CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG158875|UniProtKB=T1ENC8 T1ENC8 20198078 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG185019|UniProtKB=T1FMA4 T1FMA4 20209953 PTHR19282:SF544 TETRASPANIN TETRASPANIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG191586|UniProtKB=T1FT38 T1FT38 20211985 PTHR18945:SF925 NEUROTRANSMITTER GATED ION CHANNEL DUF4706 DOMAIN-CONTAINING PROTEIN ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG195023|UniProtKB=T1FWN6 T1FWN6 20213231 PTHR21567:SF87 CLASP CRESCERIN-LIKE PROTEIN CHE-12 cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule-based process#GO:0007017;organelle organization#GO:0006996 supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cytoplasmic microtubule#GO:0005881;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG84354|UniProtKB=T1G5H9 T1G5H9 20216326 PTHR24418:SF367 TYROSINE-PROTEIN KINASE INACTIVE TYROSINE-PROTEIN KINASE KIN-32 protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;non-membrane spanning protein tyrosine kinase activity#GO:0004715;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cell junction#GO:0030054;cell-substrate junction#GO:0030055;cellular anatomical entity#GO:0110165;anchoring junction#GO:0070161;focal adhesion#GO:0005925 non-receptor tyrosine protein kinase#PC00168 Angiogenesis#P00005>FAK#P00209;VEGF signaling pathway#P00056>FAK#P01420;Integrin signalling pathway#P00034>FAK#P00932 HELRO|EnsemblGenome=HelroG123773|UniProtKB=T1EGY9 T1EGY9 20195839 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG110832|UniProtKB=T1EF55 T1EF55 20195207 PTHR13856:SF137 VHS DOMAIN CONTAINING PROTEIN FAMILY GH05942P protein binding#GO:0005515;clathrin binding#GO:0030276;binding#GO:0005488 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG169045|UniProtKB=T1F1B2 T1F1B2 20202612 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG186399|UniProtKB=T1FNZ1 T1FNZ1 20210538 PTHR11730:SF60 AMMONIUM TRANSPORTER RH50, ISOFORM D inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;inorganic cation transmembrane transporter activity#GO:0022890;channel activity#GO:0015267 localization#GO:0051179;inorganic ion homeostasis#GO:0098771;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;nitrogen compound transport#GO:0071705;homeostatic process#GO:0042592;inorganic ion transmembrane transport#GO:0098660;chemical homeostasis#GO:0048878;cellular process#GO:0009987 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG164056|UniProtKB=T1EUU6 T1EUU6 20200346 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185422|UniProtKB=T1FMT0 T1FMT0 20210129 PTHR19877:SF1 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I nucleic acid binding#GO:0003676;RNA binding#GO:0003723;translation regulator activity#GO:0045182;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation initiation factor activity#GO:0003743;translation regulator activity, nucleic acid binding#GO:0090079;translation factor activity, RNA binding#GO:0008135 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cytoplasmic translation#GO:0002181;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cytoplasmic translational initiation#GO:0002183;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;translational initiation#GO:0006413;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;eukaryotic translation initiation factor 3 complex#GO:0005852;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG107238|UniProtKB=T1EE89 T1EE89 20194891 PTHR13325:SF3 PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 membrane protein proteolysis#GO:0033619;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG190344|UniProtKB=T1FRX3 T1FRX3 20211570 PTHR46606:SF5 SHOOTIN-1 SHOOTIN-1 neurogenesis#GO:0022008;cell projection organization#GO:0030030;regulation of locomotion#GO:0040012;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;regulation of biological process#GO:0050789;system development#GO:0048731;cell differentiation#GO:0030154;regulation of cell migration#GO:0030334;anatomical structure morphogenesis#GO:0009653;positive regulation of cell motility#GO:2000147;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;positive regulation of biological process#GO:0048518;cellular developmental process#GO:0048869;regulation of cell motility#GO:2000145;positive regulation of locomotion#GO:0040017;multicellular organism development#GO:0007275;cellular component organization#GO:0016043;cell morphogenesis#GO:0000902;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;positive regulation of cell migration#GO:0030335;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;biological regulation#GO:0065007;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 cell leading edge#GO:0031252;cytoplasm#GO:0005737;axonal growth cone#GO:0044295;neuron projection#GO:0043005;distal axon#GO:0150034;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;growth cone#GO:0030426;axon#GO:0030424;site of polarized growth#GO:0030427;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185894|UniProtKB=T1FNE7 T1FNE7 20210344 PTHR16002:SF4 TRANSMEMBRANE PROTEIN 248-LIKE TMEM248_TMEM219 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191219|UniProtKB=T1FSR2 T1FSR2 20211859 PTHR13140:SF706 MYOSIN DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C microfilament motor activity#GO:0000146;cytoskeletal protein binding#GO:0008092;ATP-dependent activity#GO:0140657;binding#GO:0005488;actin filament binding#GO:0051015;cytoskeletal motor activity#GO:0003774;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG190648|UniProtKB=T1FS61 T1FS61 20211658 PTHR33662:SF3 OTU DEUBIQUITINASE WITH LINEAR LINKAGE-SPECIFICITY A-RELATED FIBROUS SHEATH CABYR-BINDING PROTEIN-LIKE-RELATED cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG165893|UniProtKB=T1EXE8 T1EXE8 20201248 PTHR43250:SF2 EXODEOXYRIBONUCLEASE III EXODEOXYRIBONUCLEASE III HELRO|EnsemblGenome=HelroG93602|UniProtKB=T1G8W7 T1G8W7 20217514 PTHR11909:SF422 CASEIN KINASE-RELATED BCDNA.LD23371-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG89495|UniProtKB=T1G7D5 T1G7D5 20216982 PTHR12027:SF70 WNT RELATED PROTEIN WNT-16 molecular function activator activity#GO:0140677;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;protein binding#GO:0005515;cytokine activity#GO:0005125;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;neurogenesis#GO:0022008;developmental process#GO:0032502;multicellular organism development#GO:0007275;cell communication#GO:0007154;cell fate commitment#GO:0045165;cell-cell signaling by wnt#GO:0198738;nervous system development#GO:0007399;cellular process#GO:0009987;regulation of biological process#GO:0050789;system development#GO:0048731;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;cell-cell signaling#GO:0007267;signaling#GO:0023052;canonical Wnt signaling pathway#GO:0060070;Wnt signaling pathway#GO:0016055 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Cadherin signaling pathway#P00012>Wnt#P00474 HELRO|EnsemblGenome=HelroG176714|UniProtKB=T1FAT5 T1FAT5 20205934 PTHR24418:SF384 TYROSINE-PROTEIN KINASE ACTIVATED CDC42 KINASE 1 protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG167074|UniProtKB=T1EYZ3 T1EYZ3 20201793 PTHR11685:SF225 RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE RNF217 ubiquitin-like protein conjugating enzyme binding#GO:0044390;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;enzyme binding#GO:0019899;protein binding#GO:0005515;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG189260|UniProtKB=T1FQV8 T1FQV8 20211205 PTHR18966:SF422 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED signaling receptor activity#GO:0038023;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;ligand-gated channel activity#GO:0022834 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019 HELRO|EnsemblGenome=HelroG185356|UniProtKB=T1FMQ2 T1FMQ2 20210101 PTHR23030:SF39 PCD6 INTERACTING PROTEIN-RELATED PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN endosomal transport#GO:0016197;cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;protein catabolic process#GO:0030163;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;nitrogen compound transport#GO:0071705;organonitrogen compound catabolic process#GO:1901565;late endosome to vacuole transport#GO:0045324;protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043328;establishment of protein localization#GO:0045184;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;modification-dependent macromolecule catabolic process#GO:0043632;organic substance transport#GO:0071702;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein localization to organelle#GO:0033365;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;establishment of protein localization to vacuole#GO:0072666;modification-dependent protein catabolic process#GO:0019941;vacuolar transport#GO:0007034;macromolecule metabolic process#GO:0043170;protein localization to vacuole#GO:0072665;organonitrogen compound metabolic process#GO:1901564;establishment of protein localization to organelle#GO:0072594;vesicle-mediated transport#GO:0016192;multivesicular body sorting pathway#GO:0071985;cellular process#GO:0009987;protein localization#GO:0008104;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;localization#GO:0051179;cellular macromolecule localization#GO:0070727;protein transport#GO:0015031;endosome transport via multivesicular body sorting pathway#GO:0032509;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG174915|UniProtKB=T1F8M0 T1F8M0 20205169 PTHR11380:SF16 TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;gene expression#GO:0010467;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG80739|UniProtKB=T1G447 T1G447 20215845 PTHR11829:SF363 FORKHEAD BOX PROTEIN FORKHEAD BOX PROTEIN FKH-2 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;anatomical structure morphogenesis#GO:0009653;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG84905|UniProtKB=T1G5Q2 T1G5Q2 20216399 PTHR11829:SF343 FORKHEAD BOX PROTEIN FORK-HEAD DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;anatomical structure morphogenesis#GO:0009653;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG87823|UniProtKB=T1G6V8 T1G6V8 20216805 PTHR24096:SF257 LONG-CHAIN-FATTY-ACID--COA LIGASE ACYL-COA SYNTHETASE 7 ligase activity#GO:0016874;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 metabolite interconversion enzyme#PC00262;ligase#PC00142 HELRO|EnsemblGenome=HelroG153391|UniProtKB=T1EL65 T1EL65 20197315 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG181795|UniProtKB=T1FHC2 T1FHC2 20208221 PTHR13248:SF4 TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2 ELONGIN B RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG106750|UniProtKB=T1EE46 T1EE46 20194848 PTHR48092:SF9 KNIRPS-RELATED PROTEIN-RELATED KNIRPS-RELATED PROTEIN-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG164652|UniProtKB=T1EVP2 T1EVP2 20200642 PTHR21340:SF0 DIADENOSINE 5,5-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE MUTT BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [ASYMMETRICAL] pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;ribonucleoside triphosphate metabolic process#GO:0009199;nucleoside triphosphate metabolic process#GO:0009141;purine ribonucleoside monophosphate metabolic process#GO:0009167;carbohydrate derivative metabolic process#GO:1901135;ATP biosynthetic process#GO:0006754;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;nucleoside monophosphate metabolic process#GO:0009123;organic cyclic compound metabolic process#GO:1901360;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;purine nucleoside triphosphate biosynthetic process#GO:0009145;heterocycle metabolic process#GO:0046483;purine nucleoside monophosphate metabolic process#GO:0009126;purine ribonucleoside triphosphate metabolic process#GO:0009205;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;ribonucleoside triphosphate biosynthetic process#GO:0009201;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleoside monophosphate metabolic process#GO:0009161;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;purine nucleoside triphosphate metabolic process#GO:0009144;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG169090|UniProtKB=T1F1D7 T1F1D7 20202637 PTHR22923:SF116 CEREBELLIN-RELATED C1Q DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG122007|UniProtKB=T1EGT5 T1EGT5 20195785 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;heme binding#GO:0020037 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG183941|UniProtKB=T1FKB9 T1FKB9 20209268 PTHR13527:SF0 SAYSVFN DOMAIN-CONTAINING PROTEIN 1 SAYSVFN DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG185823|UniProtKB=T1FNC1 T1FNC1 20210318 PTHR45684:SF2 RE74312P RE74312P pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;membrane organization#GO:0061024;transport#GO:0006810;regulation of localization#GO:0032879;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789;regulation of transport#GO:0051049;regulation of protein-containing complex assembly#GO:0043254;establishment of localization#GO:0051234;regulation of cellular component biogenesis#GO:0044087;positive regulation of protein transport#GO:0051222;vesicle organization#GO:0016050;regulation of protein transport#GO:0051223;positive regulation of biological process#GO:0048518;regulation of protein localization#GO:0032880;positive regulation of establishment of protein localization#GO:1904951;regulation of organelle organization#GO:0033043;positive regulation of transport#GO:0051050;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;Golgi vesicle transport#GO:0048193;regulation of cellular localization#GO:0060341;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;regulation of cellular process#GO:0050794;organelle organization#GO:0006996;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;positive regulation of protein localization#GO:1903829;regulation of establishment of protein localization#GO:0070201 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;ER to Golgi transport vesicle membrane#GO:0012507;COPII-coated ER to Golgi transport vesicle#GO:0030134;endoplasmic reticulum exit site#GO:0070971;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;vesicle coat#GO:0030120;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;transport vesicle membrane#GO:0030658;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;coated vesicle membrane#GO:0030662;membrane coat#GO:0030117;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;coated membrane#GO:0048475;transport vesicle#GO:0030133;cytoplasmic vesicle membrane#GO:0030659;endoplasmic reticulum#GO:0005783 HELRO|EnsemblGenome=HelroG159395|UniProtKB=T1ENZ9 T1ENZ9 20198299 PTHR45960:SF2 GRB2-ASSOCIATED-BINDING PROTEIN PROTEIN DAUGHTER OF SEVENLESS scaffold/adaptor protein#PC00226 EGF receptor signaling pathway#P00018>Gab#P00563 HELRO|EnsemblGenome=HelroG177672|UniProtKB=T1FC19 T1FC19 20206368 PTHR21461:SF69 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 glycosylation#GO:0070085;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG182567|UniProtKB=T1FID1 T1FID1 20208580 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG90106|UniProtKB=T1G7L0 T1G7L0 20217057 PTHR22842:SF3 WD40 REPEAT PROTEIN WD REPEAT DOMAIN-CONTAINING PROTEIN 83 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;catalytic step 2 spliceosome#GO:0071013;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG65176|UniProtKB=T1FY43 T1FY43 20213741 PTHR11675:SF119 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2 transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG163596|UniProtKB=T1EU97 T1EU97 20200147 PTHR12424:SF8 TWEETY-RELATED PROTEIN TWEETY inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG64907|UniProtKB=T1FY10 T1FY10 20213708 PTHR12483:SF115 SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS COPPER TRANSPORT PROTEIN secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG177886|UniProtKB=T1FCF2 T1FCF2 20206501 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG175156|UniProtKB=T1F8X6 T1F8X6 20205275 PTHR24322:SF736 PKSB RETINOL DEHYDROGENASE 10 oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG185462|UniProtKB=T1FMU7 T1FMU7 20210146 PTHR11743:SF70 VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL GH26960P-RELATED voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216 envelope#GO:0031975;bounding membrane of organelle#GO:0098588;mitochondrial membrane#GO:0031966;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867 ion channel#PC00133;transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG75592|UniProtKB=T1G267 T1G267 20215165 PTHR11537:SF252 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;delayed rectifier potassium channel activity#GO:0005251;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG189355|UniProtKB=T1FQZ9 T1FQZ9 20211246 PTHR10501:SF41 U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B PROTEIN COUCH POTATO nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG166378|UniProtKB=T1EY26 T1EY26 20201476 PTHR33167:SF4 TRANSCRIPTION FACTOR, PUTATIVE (DUF863)-RELATED TRANSCRIPTION FACTOR, PUTATIVE (DUF863)-RELATED HELRO|EnsemblGenome=HelroG193305|UniProtKB=T1FUV1 T1FUV1 20212597 PTHR12972:SF0 DOWNSTREAM NEIGHBOR OF SON PROTEIN DOWNSTREAM NEIGHBOR OF SON cellular aromatic compound metabolic process#GO:0006725;nuclear DNA replication#GO:0033260;heterocycle metabolic process#GO:0046483;macromolecule metabolic process#GO:0043170;cell cycle process#GO:0022402;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;DNA-templated DNA replication#GO:0006261;cell cycle#GO:0007049;DNA replication#GO:0006260;DNA metabolic process#GO:0006259;cell cycle DNA replication#GO:0044786;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG165821|UniProtKB=T1EXB9 T1EXB9 20201219 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG178093|UniProtKB=T1FCQ3 T1FCQ3 20206602 PTHR22802:SF463 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG82341|UniProtKB=T1G4Q8 T1G4Q8 20216056 PTHR11829:SF142 FORKHEAD BOX PROTEIN FORK-HEAD DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;anatomical structure morphogenesis#GO:0009653;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG82615|UniProtKB=T1G4U3 T1G4U3 20216091 PTHR11920:SF501 GUANYLYL CYCLASE GUANYLATE CYCLASE 32E adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG183966|UniProtKB=T1FKD3 T1FKD3 20209282 PTHR10656:SF42 CELL FATE DETERMINING PROTEIN MAB21-RELATED CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED transferase#PC00220;nucleotidyltransferase#PC00174;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG111023|UniProtKB=T1EF72 T1EF72 20195224 PTHR10502:SF102 ANNEXIN ANNEXIN B11 lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488;phosphatidylserine binding#GO:0001786 cytoplasm#GO:0005737;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG98091|UniProtKB=T1G9K5 T1G9K5 20217751 PTHR11848:SF308 TGF-BETA FAMILY BMP-LIKE PROTEIN UNC-129 molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;binding#GO:0005488;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;protein binding#GO:0005515;signaling receptor binding#GO:0005102 extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HELRO|EnsemblGenome=HelroG79566|UniProtKB=T1G3Q1 T1G3Q1 20215699 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG98671|UniProtKB=T1G9P3 T1G9P3 20217789 PTHR10257:SF89 SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM phosphatase regulator activity#GO:0019208;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888 macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;dephosphorylation#GO:0016311;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;protein metabolic process#GO:0019538;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 Wnt signaling pathway#P00057>PP2A#P01438;FGF signaling pathway#P00021>PP2A#P00629;EGF receptor signaling pathway#P00018>PP2A#P00547 HELRO|EnsemblGenome=HelroG172419|UniProtKB=T1F5A9 T1F5A9 20204008 PTHR24320:SF226 RETINOL DEHYDROGENASE RETINOL DEHYDROGENASE 11 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG194643|UniProtKB=T1FW98 T1FW98 20213094 PTHR21428:SF11 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;core mediator complex#GO:0070847;RNA polymerase II transcription regulator complex#GO:0090575;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG157030|UniProtKB=T1EM49 T1EM49 20197649 PTHR24286:SF24 CYTOCHROME P450 26 LANOSTEROL 14-ALPHA DEMETHYLASE oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 sterol metabolic process#GO:0016125;organic hydroxy compound metabolic process#GO:1901615;lipid metabolic process#GO:0006629;steroid metabolic process#GO:0008202;organic cyclic compound metabolic process#GO:1901360;metabolic process#GO:0008152;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG175162|UniProtKB=T1F8X9 T1F8X9 20205278 PTHR31196:SF2 RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED HELRO|EnsemblGenome=HelroG71212|UniProtKB=T1G0H9 T1G0H9 20214577 PTHR11034:SF40 N-MYC DOWNSTREAM REGULATED BCDNA.GH02439 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG142541|UniProtKB=T1EJ61 T1EJ61 20196611 PTHR48051:SF54 FAMILY NOT NAMED LEUCINE-RICH REPEAT-CONTAINING PROTEIN cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG111074|UniProtKB=T1EF76 T1EF76 20195228 PTHR12315:SF0 BICOID-INTERACTING PROTEIN RELATED 7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME catalytic activity, acting on RNA#GO:0140098;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;transferase activity#GO:0016740;O-methyltransferase activity#GO:0008171;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640;methyltransferase activity#GO:0008168;snRNA binding#GO:0017069;transferase activity, transferring one-carbon groups#GO:0016741;RNA methyltransferase activity#GO:0008173 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;snRNA metabolic process#GO:0016073;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG159814|UniProtKB=T1EPF5 T1EPF5 20198455 PTHR22769:SF56 MUTT/NUDIX HYDROLASE 8-OXO-DGDP PHOSPHATASE NUDT18 hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;nucleoside diphosphate phosphatase activity#GO:0017110;catalytic activity#GO:0003824 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG190880|UniProtKB=T1FSD8 T1FSD8 20211735 PTHR24180:SF57 CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 kinase inhibitor#PC00139 HELRO|EnsemblGenome=HelroG162973|UniProtKB=T1ETG8 T1ETG8 20199868 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG159484|UniProtKB=T1EP31 T1EP31 20198331 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG160285|UniProtKB=T1EQ20 T1EQ20 20198670 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG107348|UniProtKB=T1EE98 T1EE98 20194900 PTHR22884:SF498 SET DOMAIN PROTEINS HISTONE-LYSINE N-METHYLTRANSFERASE ASHH3 N-methyltransferase activity#GO:0008170;histone modifying activity#GO:0140993;transferase activity#GO:0016740;catalytic activity#GO:0003824;histone methyltransferase activity#GO:0042054;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;protein-lysine N-methyltransferase activity#GO:0016279;catalytic activity, acting on a protein#GO:0140096;lysine N-methyltransferase activity#GO:0016278;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein methyltransferase activity#GO:0008276 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG192339|UniProtKB=T1FTU4 T1FTU4 20212241 PTHR11746:SF199 O-METHYLTRANSFERASE ACETYLSEROTONIN O-METHYLTRANSFERASE methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG192740|UniProtKB=T1FU90 T1FU90 20212386 PTHR10662:SF22 NUCLEAR RNA EXPORT FACTOR NUCLEAR RNA EXPORT FACTOR 1 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 poly(A)+ mRNA export from nucleus#GO:0016973;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;mRNA transport#GO:0051028;RNA localization#GO:0006403;localization#GO:0051179;organic substance transport#GO:0071702;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG151325|UniProtKB=T1EKJ6 T1EKJ6 20197096 PTHR21404:SF3 HEN1 SMALL RNA 2'-O-METHYLTRANSFERASE HELRO|EnsemblGenome=HelroG158385|UniProtKB=T1EMQ9 T1EMQ9 20197859 PTHR12231:SF253 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG192580|UniProtKB=T1FU33 T1FU33 20212329 PTHR13381:SF0 RNA POLYMERASE II HOLOENZYME COMPONENT SRB7 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21 molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG179287|UniProtKB=T1FEH5 T1FEH5 20207224 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183685|UniProtKB=T1FK12 T1FK12 20209161 PTHR23050:SF518 CALCIUM BINDING PROTEIN AT16150P-RELATED cation binding#GO:0043169;small molecule binding#GO:0036094;molecular function regulator activity#GO:0098772;binding#GO:0005488;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;enzyme regulator activity#GO:0030234 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061 B cell activation#P00010>Calmodulin#P00375;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Calmodulin#P00755;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716;T cell activation#P00053>Calmodulin#P01305 HELRO|EnsemblGenome=HelroG177179|UniProtKB=T1FBB9 T1FBB9 20206118 PTHR15034:SF5 DEATH DOMAIN-CONTAINING PROTEIN CRADD DEATH DOMAIN-CONTAINING PROTEIN CRADD Wnt signaling pathway#P00057>Frizzled#P01428;Apoptosis signaling pathway#P00006>RAIDD#P00294;Cadherin signaling pathway#P00012>Frizzled#P00475;Alzheimer disease-presenilin pathway#P00004>Frizzled#P00119 HELRO|EnsemblGenome=HelroG116640|UniProtKB=T1EGG8 T1EGG8 20195670 PTHR46317:SF1 HYDROLASE OF PHP SUPERFAMILY-RELATED PROTEIN HYDROLASE, TATD FAMILY metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG175459|UniProtKB=T1F9A2 T1F9A2 20205401 PTHR33562:SF28 ATILLA, ISOFORM B-RELATED-RELATED PROTEIN QUIVER HELRO|EnsemblGenome=HelroG157480|UniProtKB=T1EMC0 T1EMC0 20197720 PTHR11024:SF2 NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER PROTEIN SEC13 HOMOLOG endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;macromolecule localization#GO:0033036;membrane organization#GO:0061024;transport#GO:0006810;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;establishment of protein localization#GO:0045184;organic substance transport#GO:0071702;protein import into nucleus#GO:0006606;establishment of localization#GO:0051234;vesicle organization#GO:0016050;protein localization to organelle#GO:0033365;nuclear transport#GO:0051169;establishment of protein localization to organelle#GO:0072594;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;cellular macromolecule localization#GO:0070727;vesicle budding from membrane#GO:0006900;nucleocytoplasmic transport#GO:0006913;organelle organization#GO:0006996;protein transport#GO:0015031;COPII-coated vesicle budding#GO:0090114;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;import into nucleus#GO:0051170 bounding membrane of organelle#GO:0098588;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;transport vesicle membrane#GO:0030658;membrane coat#GO:0030117;coated membrane#GO:0048475;cytoplasmic vesicle membrane#GO:0030659;envelope#GO:0031975;nuclear pore#GO:0005643;membrane protein complex#GO:0098796;ER to Golgi transport vesicle membrane#GO:0012507;nucleus#GO:0005634;intracellular vesicle#GO:0097708;membrane#GO:0016020;coated vesicle#GO:0030135;vesicle coat#GO:0030120;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;coated vesicle membrane#GO:0030662;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;transport vesicle#GO:0030133;nuclear protein-containing complex#GO:0140513 transporter#PC00227 HELRO|EnsemblGenome=HelroG164490|UniProtKB=T1EVH9 T1EVH9 20200579 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG94141|UniProtKB=T1G8Z1 T1G8Z1 20217538 PTHR16263:SF4 TETRATRICOPEPTIDE REPEAT PROTEIN 38 TETRATRICOPEPTIDE REPEAT PROTEIN 38 HELRO|EnsemblGenome=HelroG84308|UniProtKB=T1G5H4 T1G5H4 20216321 PTHR13140:SF709 MYOSIN UNCONVENTIONAL MYOSIN-XV microfilament motor activity#GO:0000146;cytoskeletal protein binding#GO:0008092;ATP-dependent activity#GO:0140657;binding#GO:0005488;actin filament binding#GO:0051015;cytoskeletal motor activity#GO:0003774;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG62093|UniProtKB=T1FWV6 T1FWV6 20213304 PTHR21011:SF1 MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6 SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;rRNA binding#GO:0019843;binding#GO:0005488;organic cyclic compound binding#GO:0097159 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG185089|UniProtKB=T1FMD7 T1FMD7 20209986 PTHR21252:SF2 TB1 PROTEIN-RELATED MITOCHONDRIAL OUTER MEMBRANE PROTEIN SLC25A46 cellular component organization or biogenesis#GO:0071840;organelle fission#GO:0048285;mitochondrion organization#GO:0007005;cellular component organization#GO:0016043;cellular process#GO:0009987;organelle organization#GO:0006996;mitochondrial fission#GO:0000266 envelope#GO:0031975;bounding membrane of organelle#GO:0098588;mitochondrial membrane#GO:0031966;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867 HELRO|EnsemblGenome=HelroG183752|UniProtKB=T1FK53 T1FK53 20209202 PTHR19303:SF73 TRANSPOSON PROTEIN PDC2 nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG172568|UniProtKB=T1F5J1 T1F5J1 20204090 PTHR19303:SF71 TRANSPOSON ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG183488|UniProtKB=T1FJR2 T1FJR2 20209061 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG86254|UniProtKB=T1G694 T1G694 20216591 PTHR31200:SF1 INO80 COMPLEX SUBUNIT C INO80 COMPLEX SUBUNIT C cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;protein-DNA complex organization#GO:0071824;cellular component organization#GO:0016043;cellular process#GO:0009987;chromatin remodeling#GO:0006338;protein-containing complex organization#GO:0043933 HELRO|EnsemblGenome=HelroG191962|UniProtKB=T1FTG5 T1FTG5 20212112 PTHR23072:SF0 PHOSPHATIDYLINOSITOL GLYCAN-RELATED GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;phospholipid biosynthetic process#GO:0008654;macromolecule modification#GO:0043412;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycolipid metabolic process#GO:0006664;protein modification process#GO:0036211;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;glycerolipid biosynthetic process#GO:0045017;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;organic substance biosynthetic process#GO:1901576;liposaccharide metabolic process#GO:1903509;cellular process#GO:0009987;GPI anchor metabolic process#GO:0006505;membrane lipid biosynthetic process#GO:0046467;lipoprotein biosynthetic process#GO:0042158;primary metabolic process#GO:0044238;GPI anchor biosynthetic process#GO:0006506;carbohydrate derivative biosynthetic process#GO:1901137;membrane lipid metabolic process#GO:0006643;glycerophospholipid biosynthetic process#GO:0046474;glycolipid biosynthetic process#GO:0009247;organophosphate metabolic process#GO:0019637;lipoprotein metabolic process#GO:0042157;cellular lipid metabolic process#GO:0044255 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG83158|UniProtKB=T1G513 T1G513 20216161 PTHR10457:SF7 MEVALONATE KINASE/GALACTOKINASE GALACTOKINASE-RELATED transferase activity, transferring phosphorus-containing groups#GO:0016772;carbohydrate kinase activity#GO:0019200;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 monosaccharide metabolic process#GO:0005996;hexose metabolic process#GO:0019318;carbohydrate metabolic process#GO:0005975;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;carbohydrate kinase#PC00065 Fructose galactose metabolism#P02744>Galactokinase#P02960 HELRO|EnsemblGenome=HelroG122321|UniProtKB=T1EGU5 T1EGU5 20195795 PTHR11073:SF2 CALRETICULIN AND CALNEXIN CALRETICULIN cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 protein catabolic process#GO:0030163;gene expression#GO:0010467;organonitrogen compound catabolic process#GO:1901565;biosynthetic process#GO:0009058;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;macromolecule catabolic process#GO:0009057;response to endoplasmic reticulum stress#GO:0034976;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;protein maturation#GO:0051604;ERAD pathway#GO:0036503;cellular biosynthetic process#GO:0044249;response to organonitrogen compound#GO:0010243;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;protein folding#GO:0006457;cellular response to stress#GO:0033554 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG193838|UniProtKB=T1FVE7 T1FVE7 20212793 PTHR35836:SF1 VCBS REPEAT-CONTAINING PROTEIN VCBS REPEAT-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG82389|UniProtKB=T1G4R7 T1G4R7 20216065 PTHR24356:SF414 SERINE/THREONINE-PROTEIN KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG186712|UniProtKB=T1FP24 T1FP24 20210571 PTHR14269:SF4 CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED CAT EYE SYNDROME CRITICAL REGION PROTEIN 5 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;glycerophospholipid metabolic process#GO:0006650;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;primary metabolic process#GO:0044238;glycerolipid metabolic process#GO:0046486;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG174017|UniProtKB=T1F7H4 T1F7H4 20204773 PTHR11618:SF13 TRANSCRIPTION INITIATION FACTOR IIB-RELATED TRANSCRIPTION INITIATION FACTOR IIB cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;gene expression#GO:0010467;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;aromatic compound biosynthetic process#GO:0019438;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein-containing complex#GO:0032991;protein-DNA complex#GO:0032993 general transcription factor#PC00259 Transcription regulation by bZIP transcription factor#P00055>TFIIB#P01397;General transcription regulation#P00023>TFIIB#P00668 HELRO|EnsemblGenome=HelroG182210|UniProtKB=T1FHX6 T1FHX6 20208425 PTHR46077:SF5 E3 UBIQUITIN-PROTEIN LIGASE TOPORS RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein monoubiquitination#GO:0006513;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG164414|UniProtKB=T1EVE3 T1EVE3 20200543 PTHR24324:SF9 HOMEOBOX PROTEIN HHEX HOMEOBOX DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG171208|UniProtKB=T1F3Y0 T1F3Y0 20203529 PTHR44755:SF8 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide hormone binding#GO:0017046;hormone binding#GO:0042562;binding#GO:0005488;peptide binding#GO:0042277;amide binding#GO:0033218 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG173556|UniProtKB=T1F6Y9 T1F6Y9 20204588 PTHR13586:SF0 SCD6 PROTEIN-RELATED TRAILER HITCH, ISOFORM H nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;non-membrane-bounded organelle assembly#GO:0140694;P-body assembly#GO:0033962;cellular process#GO:0009987 supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;P-body#GO:0000932;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic ribonucleoprotein granule#GO:0036464 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG162880|UniProtKB=T1ETB2 T1ETB2 20199812 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186716|UniProtKB=T1FP25 T1FP25 20210572 PTHR13703:SF61 SMAD PROTEIN MOTHERS AGAINST DPP cis-regulatory region sequence-specific DNA binding#GO:0000987;SMAD binding#GO:0046332;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;protein binding#GO:0005515;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 signal transduction#GO:0007165;regulation of nitrogen compound metabolic process#GO:0051171;response to growth factor#GO:0070848;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;cellular response to BMP stimulus#GO:0071773;cell differentiation#GO:0030154;response to endogenous stimulus#GO:0009719;anatomical structure morphogenesis#GO:0009653;regulation of biosynthetic process#GO:0009889;response to BMP#GO:0071772;regulation of macromolecule biosynthetic process#GO:0010556;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;regulation of gene expression#GO:0010468;signaling#GO:0023052;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;cellular response to endogenous stimulus#GO:0071495;regulation of DNA-templated transcription#GO:0006355;BMP signaling pathway#GO:0030509;cell communication#GO:0007154;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;cellular response to growth factor stimulus#GO:0071363;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;cell surface receptor signaling pathway#GO:0007166;anatomical structure development#GO:0048856;transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0007178;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 MYO signaling pathway#P06215>MED#P06311;Wnt signaling pathway#P00057>Smad4#P01455;DPP signaling pathway#P06213>MED#P06279;BMP/activin signaling pathway-drosophila#P06211>R-Smad#P06245;DPP-SCW signaling pathway#P06212>MED#P06265;SCW signaling pathway#P06216>MAD#P06331;GBB signaling pathway#P06214>MAD#P06305;SCW signaling pathway#P06216>MED#P06323;Activin beta signaling pathway#P06210>MED#P06233;DPP-SCW signaling pathway#P06212>MAD#P06271;DPP signaling pathway#P06213>MAD#P06288;GBB signaling pathway#P06214>MED#P06299;TGF-beta signaling pathway#P00052>RSmads#P01292;ALP23B signaling pathway#P06209>MED#P06221 HELRO|EnsemblGenome=HelroG164221|UniProtKB=T1EV42 T1EV42 20200442 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192744|UniProtKB=T1FU93 T1FU93 20212389 PTHR18902:SF31 NUCLEAR MITOTIC APPARATUS PROTEIN 1-RELATED PERICENTRIN_AKAP-450 CENTROSOMAL TARGETING DOMAIN-CONTAINING PROTEIN cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG112966|UniProtKB=T1EFN7 T1EFN7 20195389 PTHR12709:SF1 DNA-DIRECTED RNA POLYMERASE II, III DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;transcription by RNA polymerase III#GO:0006383;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;aromatic compound biosynthetic process#GO:0019438;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;RNA polymerase III complex#GO:0005666;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG175169|UniProtKB=T1F8Y5 T1F8Y5 20205284 PTHR10807:SF110 MYOTUBULARIN-RELATED FI17948P1 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 lipid metabolic process#GO:0006629;phospholipid dephosphorylation#GO:0046839;phosphatidylinositol dephosphorylation#GO:0046856;cellular metabolic process#GO:0044237;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;lipid modification#GO:0030258;cellular process#GO:0009987;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;dephosphorylation#GO:0016311;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG62279|UniProtKB=T1FWY5 T1FWY5 20213333 PTHR24075:SF6 SEC63 DOMAIN-CONTAINING ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3 ATP-dependent activity, acting on DNA#GO:0008094;3'-5' DNA helicase activity#GO:0043138;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG160102|UniProtKB=T1EPS6 T1EPS6 20198576 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194225|UniProtKB=T1FVU1 T1FVU1 20212937 PTHR10791:SF30 RAG1-ACTIVATING PROTEIN 1 SUGAR TRANSPORTER SWEET1 transmembrane transporter activity#GO:0022857;sugar transmembrane transporter activity#GO:0051119;transporter activity#GO:0005215;carbohydrate transmembrane transporter activity#GO:0015144 localization#GO:0051179;organic substance transport#GO:0071702;establishment of localization#GO:0051234;carbohydrate transport#GO:0008643;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG172587|UniProtKB=T1F5K1 T1F5K1 20204100 PTHR10985:SF77 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED GH26014P sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of multicellular organismal process#GO:0051239;regulation of cell development#GO:0060284;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regionalization#GO:0003002;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of RNA biosynthetic process#GO:2001141;regulation of multicellular organismal development#GO:2000026;regulation of cell differentiation#GO:0045595;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of neurogenesis#GO:0050767;regulation of macromolecule metabolic process#GO:0060255;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;regulation of nervous system development#GO:0051960;biological regulation#GO:0065007;anterior/posterior pattern specification#GO:0009952;multicellular organismal process#GO:0032501;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;pattern specification process#GO:0007389;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG181489|UniProtKB=T1FH21 T1FH21 20208120 PTHR10649:SF12 ARYL HYDROCARBON RECEPTOR SPINELESS, ISOFORM C sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;molecular transducer activity#GO:0060089;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG181119|UniProtKB=T1FGM7 T1FGM7 20207976 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189209|UniProtKB=T1FQS7 T1FQS7 20211174 PTHR15668:SF4 JM1 PROTEIN COILED-COIL DOMAIN-CONTAINING PROTEIN 22 cullin family protein binding#GO:0097602;protein binding#GO:0005515;binding#GO:0005488 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of proteolysis#GO:0030162;regulation of protein metabolic process#GO:0051246;regulation of catabolic process#GO:0009894;positive regulation of proteolysis involved in protein catabolic process#GO:1903052;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;regulation of proteolysis involved in protein catabolic process#GO:1903050;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of proteolysis#GO:0045862;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;positive regulation of protein metabolic process#GO:0051247;positive regulation of metabolic process#GO:0009893;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;positive regulation of catabolic process#GO:0009896;positive regulation of biological process#GO:0048518;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;regulation of metabolic process#GO:0019222 HELRO|EnsemblGenome=HelroG166700|UniProtKB=T1EYE1 T1EYE1 20201591 PTHR22730:SF1 PROMININ PROM PROTEIN PROMININ-LIKE PROTEIN HELRO|EnsemblGenome=HelroG164074|UniProtKB=T1EUV9 T1EUV9 20200359 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG185472|UniProtKB=T1FMV0 T1FMV0 20210149 PTHR11106:SF72 GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED GANGLIOSIDE-INDUCED DIFFERENTIATION-ASSOCIATED PROTEIN 2 HELRO|EnsemblGenome=HelroG169099|UniProtKB=T1F1E2 T1F1E2 20202642 PTHR13817:SF173 TITIN FRAZZLED structural protein#PC00211 HELRO|EnsemblGenome=HelroG173823|UniProtKB=T1F7A2 T1F7A2 20204701 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189063|UniProtKB=T1FQL9 T1FQL9 20211116 PTHR11616:SF321 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;organic acid:sodium symporter activity#GO:0005343;organic acid transmembrane transporter activity#GO:0005342;symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;organic anion transmembrane transporter activity#GO:0008514;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;amino acid:sodium symporter activity#GO:0005283;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;amino acid transmembrane transporter activity#GO:0015171;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;organic anion transport#GO:0015711;amino acid transport#GO:0006865;organic acid transport#GO:0015849;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;nitrogen compound transport#GO:0071705;carboxylic acid transport#GO:0046942;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;amino acid import across plasma membrane#GO:0089718;carboxylic acid transmembrane transport#GO:1905039;localization#GO:0051179;organic substance transport#GO:0071702;import across plasma membrane#GO:0098739;amino acid transmembrane transport#GO:0003333;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transport#GO:0006812;organic acid transmembrane transport#GO:1903825;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>CHT1#P01084 HELRO|EnsemblGenome=HelroG176359|UniProtKB=T1FAG0 T1FAG0 20205809 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG96652|UniProtKB=T1G9D0 T1G9D0 20217677 PTHR12957:SF2 DEAD/H BOX POLYPEPTIDE 26/DICE1-RELATED INTEGRATOR COMPLEX SUBUNIT 6 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;snRNA metabolic process#GO:0016073;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;snRNA 3'-end processing#GO:0034472;snRNA processing#GO:0016180;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;integrator complex#GO:0032039 RNA metabolism protein#PC00031;RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG173200|UniProtKB=T1F6J8 T1F6J8 20204447 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG89391|UniProtKB=T1G7C7 T1G7C7 20216974 PTHR13759:SF1 TWINFILIN TWINFILIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin monomer binding#GO:0003785;actin filament binding#GO:0051015 negative regulation of protein polymerization#GO:0032272;cellular localization#GO:0051641;negative regulation of protein depolymerization#GO:1901880;negative regulation of biological process#GO:0048519;negative regulation of actin filament depolymerization#GO:0030835;macromolecule localization#GO:0033036;regulation of cellular component organization#GO:0051128;regulation of actin polymerization or depolymerization#GO:0008064;regulation of biological process#GO:0050789;regulation of cytoskeleton organization#GO:0051493;cellular component disassembly#GO:0022411;actin filament-based process#GO:0030029;regulation of protein-containing complex assembly#GO:0043254;regulation of biological quality#GO:0065008;regulation of cellular component biogenesis#GO:0044087;supramolecular fiber organization#GO:0097435;negative regulation of organelle organization#GO:0010639;negative regulation of protein-containing complex disassembly#GO:0043242;actin filament organization#GO:0007015;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;regulation of actin filament-based process#GO:0032970;barbed-end actin filament capping#GO:0051016;negative regulation of cellular component organization#GO:0051129;regulation of protein polymerization#GO:0032271;negative regulation of cellular process#GO:0048523;regulation of anatomical structure size#GO:0090066;protein-containing complex disassembly#GO:0032984;regulation of actin filament length#GO:0030832;regulation of organelle organization#GO:0033043;regulation of actin filament organization#GO:0110053;actin polymerization or depolymerization#GO:0008154;protein depolymerization#GO:0051261;regulation of protein-containing complex disassembly#GO:0043244;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of actin filament polymerization#GO:0030833;regulation of cellular component size#GO:0032535;protein localization#GO:0008104;actin filament depolymerization#GO:0030042;negative regulation of supramolecular fiber organization#GO:1902904;localization#GO:0051179;regulation of supramolecular fiber organization#GO:1902903;cellular component organization or biogenesis#GO:0071840;cellular macromolecule localization#GO:0070727;regulation of protein depolymerization#GO:1901879;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;maintenance of location#GO:0051235;regulation of actin filament depolymerization#GO:0030834;regulation of cellular process#GO:0050794;maintenance of location in cell#GO:0051651;negative regulation of actin filament polymerization#GO:0030837;biological regulation#GO:0065007;negative regulation of protein-containing complex assembly#GO:0031333;actin cytoskeleton organization#GO:0030036;negative regulation of cytoskeleton organization#GO:0051494 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;organelle#GO:0043226;actin filament#GO:0005884;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG194303|UniProtKB=T1FVW7 T1FVW7 20212963 PTHR21646:SF74 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 19 cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG81234|UniProtKB=T1G4B9 T1G4B9 20215917 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG71321|UniProtKB=T1G0J6 T1G0J6 20214594 PTHR46399:SF8 B30.2/SPRY DOMAIN-CONTAINING PROTEIN B30.2_SPRY DOMAIN-CONTAINING PROTEIN calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;inorganic cation transmembrane transporter activity#GO:0022890;ligand-gated channel activity#GO:0022834 negative regulation of biological process#GO:0048519;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;regulation of sequestering of calcium ion#GO:0051282;system process#GO:0003008;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;release of sequestered calcium ion into cytosol#GO:0051209;regulation of localization#GO:0032879;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;striated muscle contraction#GO:0006941;calcium ion transport#GO:0006816;localization#GO:0051179;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;calcium ion transmembrane import into cytosol#GO:0097553;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;multicellular organismal process#GO:0032501;monoatomic ion transport#GO:0006811;negative regulation of sequestering of calcium ion#GO:0051283;monoatomic cation transmembrane transport#GO:0098655;negative regulation of cellular process#GO:0048523;muscle system process#GO:0003012;muscle contraction#GO:0006936 bounding membrane of organelle#GO:0098588;supramolecular complex#GO:0099080;intracellular membrane-bounded organelle#GO:0043231;transporter complex#GO:1990351;organelle membrane#GO:0031090;supramolecular polymer#GO:0099081;cellular anatomical entity#GO:0110165;organelle#GO:0043226;calcium channel complex#GO:0034704;intracellular organelle#GO:0043229;sarcolemma#GO:0042383;non-membrane-bounded organelle#GO:0043228;endoplasmic reticulum subcompartment#GO:0098827;sarcomere#GO:0030017;transmembrane transporter complex#GO:1902495;myofibril#GO:0030016;membrane protein complex#GO:0098796;sarcoplasmic reticulum#GO:0016529;Z disc#GO:0030018;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;cell periphery#GO:0071944;supramolecular fiber#GO:0099512;membrane#GO:0016020;contractile fiber#GO:0043292;cation channel complex#GO:0034703;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;plasma membrane#GO:0005886;endoplasmic reticulum membrane#GO:0005789;I band#GO:0031674 HELRO|EnsemblGenome=HelroG101782|UniProtKB=T1ED70 T1ED70 20194522 PTHR31058:SF2 ZINC FINGER C4H2 DOMAIN-CONTAINING PROTEIN ZINC FINGER C4H2 DOMAIN-CONTAINING PROTEIN regulation of biological process#GO:0050789;positive regulation of cell differentiation#GO:0045597;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cell differentiation#GO:0045595;positive regulation of biological process#GO:0048518;regulation of neuron differentiation#GO:0045664;positive regulation of developmental process#GO:0051094;positive regulation of cellular process#GO:0048522 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG182979|UniProtKB=T1FJ14 T1FJ14 20208813 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171153|UniProtKB=T1F3V6 T1F3V6 20203505 PTHR12694:SF8 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;gene expression#GO:0010467;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 RNA metabolism protein#PC00031;general transcription factor#PC00259 General transcription regulation#P00023>TFIIA complex#P00662;Transcription regulation by bZIP transcription factor#P00055>TFIIA complex#P01390 HELRO|EnsemblGenome=HelroG189956|UniProtKB=T1FRJ0 T1FRJ0 20211437 PTHR31525:SF1 HEME TRANSPORTER HRG1 HEME TRANSPORTER HRG1 tetrapyrrole binding#GO:0046906;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;binding#GO:0005488;organic cyclic compound binding#GO:0097159;heme binding#GO:0020037 localization#GO:0051179;organic substance transport#GO:0071702;metal ion transport#GO:0030001;establishment of localization#GO:0051234;transport#GO:0006810;monoatomic cation transport#GO:0006812;nitrogen compound transport#GO:0071705;iron ion transport#GO:0006826;transition metal ion transport#GO:0000041;monoatomic ion transport#GO:0006811 bounding membrane of organelle#GO:0098588;lytic vacuole membrane#GO:0098852;intracellular membrane-bounded organelle#GO:0043231;vacuolar membrane#GO:0005774;vacuole#GO:0005773;organelle membrane#GO:0031090;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;lytic vacuole#GO:0000323;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;lysosomal membrane#GO:0005765;lysosome#GO:0005764;membrane-bounded organelle#GO:0043227;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG81437|UniProtKB=T1G4E3 T1G4E3 20215941 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG182996|UniProtKB=T1FJ26 T1FJ26 20208825 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG176045|UniProtKB=T1FA28 T1FA28 20205677 PTHR45713:SF15 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG69270|UniProtKB=T1FZS5 T1FZS5 20214323 PTHR11453:SF36 ANION EXCHANGE PROTEIN ANION EXCHANGE PROTEIN secondary active transmembrane transporter activity#GO:0015291;inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;symporter activity#GO:0015293;active monoatomic ion transmembrane transporter activity#GO:0022853;solute:sodium symporter activity#GO:0015370;organic anion transmembrane transporter activity#GO:0008514;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;inorganic cation transmembrane transporter activity#GO:0022890;transporter activity#GO:0005215;solute:monoatomic cation symporter activity#GO:0015294 regulation of intracellular pH#GO:0051453;transmembrane transport#GO:0055085;organic anion transport#GO:0015711;transport#GO:0006810;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;regulation of pH#GO:0006885;organic substance transport#GO:0071702;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;intracellular monoatomic cation homeostasis#GO:0030003;biological regulation#GO:0065007;intracellular monoatomic ion homeostasis#GO:0006873;regulation of cellular pH#GO:0030641 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG67318|UniProtKB=T1FYZ5 T1FYZ5 20214043 PTHR11009:SF1 DER1-LIKE PROTEIN, DERLIN DERLIN-1 ribonucleoprotein complex binding#GO:0043021;protein-containing complex binding#GO:0044877;binding#GO:0005488 signal transduction#GO:0007165;endoplasmic reticulum unfolded protein response#GO:0030968;protein catabolic process#GO:0030163;organonitrogen compound catabolic process#GO:1901565;regulation of biological process#GO:0050789;nitrogen compound metabolic process#GO:0006807;response to unfolded protein#GO:0006986;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;signaling#GO:0023052;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;response to organic substance#GO:0010033;macromolecule catabolic process#GO:0009057;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;cellular response to chemical stimulus#GO:0070887;cellular response to organic substance#GO:0071310;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;ERAD pathway#GO:0036503;cell communication#GO:0007154;response to organonitrogen compound#GO:0010243;cellular process#GO:0009987;cellular response to topologically incorrect protein#GO:0035967;primary metabolic process#GO:0044238;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;response to topologically incorrect protein#GO:0035966;cellular response to unfolded protein#GO:0034620;biological regulation#GO:0065007;cellular response to stress#GO:0033554 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG123811|UniProtKB=T1EGZ1 T1EGZ1 20195841 PTHR46803:SF2 E3 UBIQUITIN-PROTEIN LIGASE CHIP E3 UBIQUITIN-PROTEIN LIGASE CHIP transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;protein binding#GO:0005515;aminoacyltransferase activity#GO:0016755;protein-folding chaperone binding#GO:0051087;catalytic activity, acting on a protein#GO:0140096 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of protein metabolic process#GO:0051246;macromolecule modification#GO:0043412;regulation of nitrogen compound metabolic process#GO:0051171;protein catabolic process#GO:0030163;organonitrogen compound catabolic process#GO:1901565;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;positive regulation of proteolysis#GO:0045862;modification-dependent macromolecule catabolic process#GO:0043632;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;positive regulation of biological process#GO:0048518;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;response to organic substance#GO:0010033;regulation of proteolysis#GO:0030162;macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;protein quality control for misfolded or incompletely synthesized proteins#GO:0006515;cellular response to chemical stimulus#GO:0070887;protein modification by small protein conjugation or removal#GO:0070647;macromolecule metabolic process#GO:0043170;cellular response to organic substance#GO:0071310;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;organonitrogen compound metabolic process#GO:1901564;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;cellular response to topologically incorrect protein#GO:0035967;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;positive regulation of protein metabolic process#GO:0051247;response to stress#GO:0006950;response to chemical#GO:0042221;regulation of macromolecule metabolic process#GO:0060255;response to topologically incorrect protein#GO:0035966;biological regulation#GO:0065007;cellular response to stress#GO:0033554;regulation of metabolic process#GO:0019222 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Parkinson disease#P00049>CHIP#P01214 HELRO|EnsemblGenome=HelroG180250|UniProtKB=T1FFM8 T1FFM8 20207627 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG168014|UniProtKB=T1F025 T1F025 20202175 PTHR31640:SF1 TRANSMEMBRANE PROTEIN KIAA1109 BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 1 HELRO|EnsemblGenome=HelroG156370|UniProtKB=T1ELU6 T1ELU6 20197546 PTHR10804:SF11 PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P PROLIFERATION-ASSOCIATED PROTEIN 2G4 protease#PC00190 HELRO|EnsemblGenome=HelroG65686|UniProtKB=T1FYB4 T1FYB4 20213812 PTHR11599:SF44 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT BETA-RELATED hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;proteasome complex#GO:0000502;membrane-bounded organelle#GO:0043227;endopeptidase complex#GO:1905369;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protease#PC00190;protein modifying enzyme#PC00260 Parkinson disease#P00049>20S proteasome#P01227 HELRO|EnsemblGenome=HelroG182817|UniProtKB=T1FIS9 T1FIS9 20208728 PTHR23107:SF34 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN HTH LA-TYPE RNA-BINDING DOMAIN-CONTAINING PROTEIN transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG193107|UniProtKB=T1FUM6 T1FUM6 20212522 PTHR22826:SF211 RHO GUANINE EXCHANGE FACTOR-RELATED LD43457P nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG140465|UniProtKB=T1EJ10 T1EJ10 20196560 PTHR11533:SF299 PROTEASE M1 ZINC METALLOPROTEASE AMINOPEPTIDASE metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;amide binding#GO:0033218;metal ion binding#GO:0046872;peptidase activity#GO:0008233;metalloaminopeptidase activity#GO:0070006;cation binding#GO:0043169;peptide binding#GO:0042277;hydrolase activity#GO:0016787;aminopeptidase activity#GO:0004177;exopeptidase activity#GO:0008238;ion binding#GO:0043167;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;peptide catabolic process#GO:0043171;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;membrane#GO:0016020;extracellular region#GO:0005576;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG125085|UniProtKB=T1EH42 T1EH42 20195892 PTHR21183:SF18 RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;mitochondrial gene expression#GO:0140053;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;mitochondrial translation#GO:0032543;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrial large ribosomal subunit#GO:0005762;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;organellar ribosome#GO:0000313;protein-containing complex#GO:0032991;large ribosomal subunit#GO:0015934;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840;mitochondrial protein-containing complex#GO:0098798 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG188829|UniProtKB=T1FQE4 T1FQE4 20211041 PTHR12210:SF70 DULLARD PROTEIN PHOSPHATASE CTD NUCLEAR ENVELOPE PHOSPHATASE 1 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG166392|UniProtKB=T1EY30 T1EY30 20201480 PTHR21190:SF1 GH10077P GH10077P HELRO|EnsemblGenome=HelroG187798|UniProtKB=T1FPD8 T1FPD8 20210685 PTHR11733:SF133 ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED PHOSPHATE-REGULATING NEUTRAL ENDOPEPTIDASE PHEX hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Endothelin signaling pathway#P00019>ECE1-3#P00585 HELRO|EnsemblGenome=HelroG107137|UniProtKB=T1EE77 T1EE77 20194879 PTHR11447:SF16 CELLULAR TUMOR ANTIGEN P53 P53 PROTEIN LONG FORM VARIANT 1 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 P53-like transcription factor#PC00253;immunoglobulin fold transcription factor#PC00251 Huntington disease#P00029>p53#P00797 HELRO|EnsemblGenome=HelroG164028|UniProtKB=T1EUS8 T1EUS8 20200328 PTHR23050:SF518 CALCIUM BINDING PROTEIN AT16150P-RELATED cation binding#GO:0043169;small molecule binding#GO:0036094;molecular function regulator activity#GO:0098772;binding#GO:0005488;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;enzyme regulator activity#GO:0030234 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061 B cell activation#P00010>Calmodulin#P00375;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Calmodulin#P00755;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716;T cell activation#P00053>Calmodulin#P01305 HELRO|EnsemblGenome=HelroG181039|UniProtKB=T1FGJ8 T1FGJ8 20207947 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG170661|UniProtKB=T1F3A8 T1F3A8 20203307 PTHR15034:SF5 DEATH DOMAIN-CONTAINING PROTEIN CRADD DEATH DOMAIN-CONTAINING PROTEIN CRADD Wnt signaling pathway#P00057>Frizzled#P01428;Apoptosis signaling pathway#P00006>RAIDD#P00294;Cadherin signaling pathway#P00012>Frizzled#P00475;Alzheimer disease-presenilin pathway#P00004>Frizzled#P00119 HELRO|EnsemblGenome=HelroG153317|UniProtKB=T1EL35 T1EL35 20197285 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG116983|UniProtKB=T1EGJ1 T1EGJ1 20195693 PTHR10165:SF103 LIPID PHOSPHATE PHOSPHATASE PHOSPHOLIPID PHOSPHATASE HOMOLOG 1.2 HOMOLOG hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 phospholipid dephosphorylation#GO:0046839;lipid metabolic process#GO:0006629;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;cellular metabolic process#GO:0044237;cell communication#GO:0007154;lipid modification#GO:0030258;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;dephosphorylation#GO:0016311;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG176967|UniProtKB=T1FB29 T1FB29 20206028 PTHR10760:SF2 TORSIN LD13476P-RELATED chaperone#PC00072 Parkinson disease#P00049>Torsin A#P01221 HELRO|EnsemblGenome=HelroG142574|UniProtKB=T1EJ62 T1EJ62 20196612 PTHR13174:SF3 D-GLUCURONYL C5-EPIMERASE D-GLUCURONYL C5-EPIMERASE racemase and epimerase activity, acting on carbohydrates and derivatives#GO:0016857;isomerase activity#GO:0016853;catalytic activity#GO:0003824 glycoprotein biosynthetic process#GO:0009101;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;sulfur compound metabolic process#GO:0006790;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;proteoglycan metabolic process#GO:0006029;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;proteoglycan biosynthetic process#GO:0030166;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 isomerase#PC00135;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG183923|UniProtKB=T1FKA9 T1FKA9 20209258 PTHR11034:SF40 N-MYC DOWNSTREAM REGULATED BCDNA.GH02439 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG90918|UniProtKB=T1G7X9 T1G7X9 20217176 PTHR32194:SF0 METALLOPROTEASE TLDD ATP-DEPENDENT PROTEASE SUBUNIT HSLV macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;catabolic process#GO:0009056;organonitrogen compound catabolic process#GO:1901565;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG170023|UniProtKB=T1F2J8 T1F2J8 20203048 PTHR31804:SF2 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15 CUE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG190627|UniProtKB=T1FS55 T1FS55 20211652 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG193313|UniProtKB=T1FUV4 T1FUV4 20212600 PTHR24256:SF470 TRYPTASE-RELATED INACTIVE CLIP DOMAIN-CONTAINING SERINE PROTEASE A30 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG76893|UniProtKB=T1G2Q6 T1G2Q6 20215354 PTHR19353:SF88 FATTY ACID DESATURASE 2 DELTA(5) FATTY ACID DESATURASE FAT-4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;membrane#GO:0016020 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG167990|UniProtKB=T1F017 T1F017 20202167 PTHR45694:SF18 GLUTAREDOXIN 2 GLUTAREDOXIN-1-RELATED disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;response to stress#GO:0006950;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;cellular response to oxidative stress#GO:0034599;response to oxidative stress#GO:0006979;cellular response to stress#GO:0033554;cellular process#GO:0009987 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG194371|UniProtKB=T1FVZ8 T1FVZ8 20212994 PTHR10648:SF1 SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1 phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;dephosphorylation#GO:0016311;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG86140|UniProtKB=T1G677 T1G677 20216574 PTHR11461:SF211 SERINE PROTEASE INHIBITOR, SERPIN GH10112P-RELATED protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG180358|UniProtKB=T1FFT6 T1FFT6 20207685 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177056|UniProtKB=T1FB67 T1FB67 20206066 PTHR12281:SF31 RP42 RELATED DCN1-LIKE PROTEIN 3 cullin family protein binding#GO:0097602;enzyme binding#GO:0019899;ubiquitin-like protein conjugating enzyme binding#GO:0044390;protein binding#GO:0005515;ubiquitin-like protein binding#GO:0032182;binding#GO:0005488 protein neddylation#GO:0045116;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG193300|UniProtKB=T1FUU9 T1FUU9 20212595 PTHR14191:SF3 PDZ DOMAIN CONTAINING PROTEIN NA(+)_H(+) EXCHANGE REGULATORY COFACTOR-LIKE PROTEIN NRFL-1 protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 localization#GO:0051179;protein localization to plasma membrane#GO:0072659;protein localization to cell periphery#GO:1990778;localization within membrane#GO:0051668;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;cellular process#GO:0009987;protein localization#GO:0008104 plasma membrane region#GO:0098590;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;apical part of cell#GO:0045177;plasma membrane#GO:0005886;apical plasma membrane#GO:0016324 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG128902|UniProtKB=T1EHQ8 T1EHQ8 20196108 PTHR11702:SF31 DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2 GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 HELRO|EnsemblGenome=HelroG179248|UniProtKB=T1FEF5 T1FEF5 20207204 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193322|UniProtKB=T1FUV9 T1FUV9 20212605 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG180249|UniProtKB=T1FFM7 T1FFM7 20207626 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG153341|UniProtKB=T1EL45 T1EL45 20197295 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164946|UniProtKB=T1EW01 T1EW01 20200751 PTHR46600:SF1 THAP DOMAIN-CONTAINING THAP DOMAIN-CONTAINING PROTEIN 1 zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG190459|UniProtKB=T1FS03 T1FS03 20211600 PTHR10334:SF498 CYSTEINE-RICH SECRETORY PROTEIN-RELATED MIP16674P defense/immunity protein#PC00090 PI3 kinase pathway#P00048>scl-1#G01545 HELRO|EnsemblGenome=HelroG182345|UniProtKB=T1FI35 T1FI35 20208484 PTHR34192:SF10 PLASTOCYANIN MAJOR ISOFORM, CHLOROPLASTIC-RELATED PLASTOCYANIN MAJOR ISOFORM, CHLOROPLASTIC-RELATED HELRO|EnsemblGenome=HelroG185592|UniProtKB=T1FN05 T1FN05 20210204 PTHR13338:SF4 UPF0240 PROTEIN NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 4 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrial respiratory chain complex I assembly#GO:0032981;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;mitochondrion organization#GO:0007005;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG183359|UniProtKB=T1FJI3 T1FJI3 20208982 PTHR31905:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 58 PROTEIN MIX23 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG111155|UniProtKB=T1EF89 T1EF89 20195241 PTHR10797:SF0 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT POLY(A)-SPECIFIC RIBONUCLEASE catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787;3'-5'-RNA exonuclease activity#GO:0000175;3'-5' exonuclease activity#GO:0008408;exonuclease activity#GO:0004527;RNA nuclease activity#GO:0004540 negative regulation of gene expression#GO:0010629;regulation of catabolic process#GO:0009894;heterocycle catabolic process#GO:0046700;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;nucleobase-containing compound metabolic process#GO:0006139;RNA destabilization#GO:0050779;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;regulation of biological quality#GO:0065008;nitrogen compound metabolic process#GO:0006807;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;positive regulation of mRNA catabolic process#GO:0061014;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of catabolic process#GO:0009896;mRNA destabilization#GO:0061157;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323;positive regulation of nitrogen compound metabolic process#GO:0051173;cellular aromatic compound metabolic process#GO:0006725;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;RNA metabolic process#GO:0016070;positive regulation of cellular catabolic process#GO:0031331;cellular nitrogen compound catabolic process#GO:0044270;organic cyclic compound metabolic process#GO:1901360;positive regulation of metabolic process#GO:0009893;mRNA catabolic process#GO:0006402;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;positive regulation of mRNA metabolic process#GO:1903313;heterocycle metabolic process#GO:0046483;negative regulation of biosynthetic process#GO:0009890;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of cellular catabolic process#GO:0031329;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;positive regulation of RNA metabolic process#GO:0051254 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;protein-containing complex#GO:0032991;P-body#GO:0000932;CCR4-NOT complex#GO:0030014;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG96112|UniProtKB=T1G9A3 T1G9A3 20217650 PTHR46355:SF1 UPF0428 PROTEIN CXORF56 STING ER EXIT PROTEIN endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;endoplasmic reticulum organization#GO:0007029;membrane organization#GO:0061024;transport#GO:0006810;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 HELRO|EnsemblGenome=HelroG189416|UniProtKB=T1FR16 T1FR16 20211263 PTHR12839:SF7 NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2 REGULATOR OF NONSENSE TRANSCRIPTS 2 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;mRNA catabolic process#GO:0006402;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;organic substance catabolic process#GO:1901575;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;nuclear-transcribed mRNA catabolic process#GO:0000956;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG188219|UniProtKB=T1FPS4 T1FPS4 20210821 PTHR12801:SF158 RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED RNA EXONUCLEASE 4 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;exonuclease activity#GO:0004527;catalytic activity#GO:0003824 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;exoribonuclease#PC00099 HELRO|EnsemblGenome=HelroG140496|UniProtKB=T1EJ13 T1EJ13 20196563 PTHR24247:SF241 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE RECEPTOR 2A-RELATED signaling receptor activity#GO:0038023;G protein-coupled amine receptor activity#GO:0008227;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission#GO:0007268;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;synaptic signaling#GO:0099536;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;cell-cell signaling#GO:0007267 somatodendritic compartment#GO:0036477;neuron projection#GO:0043005;dendrite#GO:0030425;cell periphery#GO:0071944;dendritic tree#GO:0097447;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 5HT2 type receptor mediated signaling pathway#P04374>5HT2 Receptor#P04414;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720 HELRO|EnsemblGenome=HelroG191405|UniProtKB=T1FSY5 T1FSY5 20211932 PTHR24083:SF46 NUCLEAR HORMONE RECEPTOR STEROID RECEPTOR SEVEN-UP, ISOFORM A cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;signaling receptor activity#GO:0038023;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG70655|UniProtKB=T1G099 T1G099 20214497 PTHR24070:SF69 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY FI18258P1 GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG186139|UniProtKB=T1FNQ0 T1FNQ0 20210447 PTHR19375:SF395 HEAT SHOCK PROTEIN 70KDA HEAT SHOCK 70 KDA PROTEIN ISOFORM X1-RELATED cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 Hsp70 family chaperone#PC00027 Parkinson disease#P00049>Hsp70#P01208;Apoptosis signaling pathway#P00006>HSP70#P00321 HELRO|EnsemblGenome=HelroG69346|UniProtKB=T1FZT7 T1FZT7 20214335 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG67135|UniProtKB=T1FYX1 T1FYX1 20214019 PTHR23055:SF167 CALCIUM BINDING PROTEINS EF-HAND DOMAIN-CONTAINING PROTEIN cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG74196|UniProtKB=T1G1N6 T1G1N6 20214984 PTHR10993:SF7 OCTANOYLTRANSFERASE LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;protein modification process#GO:0036211;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;peptidyl-amino acid modification#GO:0018193;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 transferase#PC00220;metabolite interconversion enzyme#PC00262 Lipoate_biosynthesis#P02750>Lipoyl-protein ligase#P03003 HELRO|EnsemblGenome=HelroG94328|UniProtKB=T1G900 T1G900 20217547 PTHR24353:SF153 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;cytosol#GO:0005829;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Enkephalin release#P05913>PKA#P05972;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Endothelin signaling pathway#P00019>PKA#P00570;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059 HELRO|EnsemblGenome=HelroG194349|UniProtKB=T1FVY9 T1FVY9 20212985 PTHR12433:SF11 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 25 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 25 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG104231|UniProtKB=T1EDK5 T1EDK5 20194657 PTHR10527:SF6 IMPORTIN BETA IMPORTIN-4 signal sequence binding#GO:0005048;binding#GO:0005488;amide binding#GO:0033218;peptide binding#GO:0042277 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;protein import into nucleus#GO:0006606;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;protein localization to organelle#GO:0033365;intracellular transport#GO:0046907;nuclear transport#GO:0051169;import into nucleus#GO:0051170 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG77706|UniProtKB=T1G327 T1G327 20215475 PTHR10064:SF0 60S RIBOSOMAL PROTEIN L22 FI24544P1-RELATED structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cytoplasmic translation#GO:0002181;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;translation#GO:0006412;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG184059|UniProtKB=T1FKI2 T1FKI2 20209331 PTHR47160:SF5 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG101030|UniProtKB=T1ED26 T1ED26 20194478 PTHR11986:SF18 AMINOTRANSFERASE CLASS III ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;identical protein binding#GO:0042802;heterocyclic compound binding#GO:1901363;protein binding#GO:0005515;ion binding#GO:0043167;anion binding#GO:0043168 transaminase#PC00216 HELRO|EnsemblGenome=HelroG67244|UniProtKB=T1FYY8 T1FYY8 20214036 PTHR43220:SF21 FAMILY NOT NAMED TRANSMEMBRANE PROTEIN 41A HELRO|EnsemblGenome=HelroG184843|UniProtKB=T1FM27 T1FM27 20209876 PTHR10869:SF216 PROLYL 4-HYDROXYLASE ALPHA SUBUNIT PROCOLLAGEN-PROLINE 4-DIOXYGENASE 2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;dioxygenase activity#GO:0051213 oxoacid metabolic process#GO:0043436;heterocycle metabolic process#GO:0046483;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular modified amino acid metabolic process#GO:0006575;protein hydroxylation#GO:0018126;alpha-amino acid metabolic process#GO:1901605;protein metabolic process#GO:0019538;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG168651|UniProtKB=T1F0U2 T1F0U2 20202442 PTHR10361:SF28 SODIUM-BILE ACID COTRANSPORTER P3 PROTEIN-RELATED primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG89958|UniProtKB=T1G7J6 T1G7J6 20217043 PTHR12871:SF0 BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE II ALPHA-1,6-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE acetylglucosaminyltransferase activity#GO:0008375;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG94381|UniProtKB=T1G907 T1G907 20217554 PTHR24221:SF503 ATP-BINDING CASSETTE SUB-FAMILY B MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG97933|UniProtKB=T1G9J6 T1G9J6 20217742 PTHR11799:SF12 PARAOXONASE PARAOXONASE-RELATED metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG172177|UniProtKB=T1F545 T1F545 20203944 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG84251|UniProtKB=T1G5G4 T1G5G4 20216311 PTHR24068:SF128 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 H ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E3#P01490;Ubiquitin proteasome pathway#P00060>E2#P01491 HELRO|EnsemblGenome=HelroG65492|UniProtKB=T1FY86 T1FY86 20213784 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG109739|UniProtKB=T1EEW2 T1EEW2 20195114 PTHR22811:SF14 TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN LP01981P-RELATED endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;Golgi organization#GO:0007030;macromolecule localization#GO:0033036;transport#GO:0006810;endomembrane system organization#GO:0010256;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;organelle organization#GO:0006996;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;endoplasmic reticulum#GO:0005783;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG186768|UniProtKB=T1FP33 T1FP33 20210580 PTHR23420:SF0 ADENOSYLHOMOCYSTEINASE ADENOSYLHOMOCYSTEINASE hydrolase activity#GO:0016787;catalytic activity#GO:0003824 cellular metabolic process#GO:0044237;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG110122|UniProtKB=T1EEZ4 T1EEZ4 20195146 PTHR24390:SF235 ZINC FINGER PROTEIN GH09339P-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG168855|UniProtKB=T1F117 T1F117 20202517 PTHR11306:SF68 NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 2 lipid binding#GO:0008289;binding#GO:0005488;organic cyclic compound binding#GO:0097159;steroid binding#GO:0005496;sterol binding#GO:0032934 localization#GO:0051179;organic hydroxy compound transport#GO:0015850;organic substance transport#GO:0071702;establishment of localization#GO:0051234;macromolecule localization#GO:0033036;sterol transport#GO:0015918;transport#GO:0006810;lipid localization#GO:0010876;lipid transport#GO:0006869 HELRO|EnsemblGenome=HelroG180097|UniProtKB=T1FFG8 T1FFG8 20207567 PTHR12232:SF15 SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH PROTEIN HOMOLOG cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG114036|UniProtKB=T1EFY4 T1EFY4 20195486 PTHR43636:SF2 ELONGATION FACTOR G, MITOCHONDRIAL ELONGATION FACTOR G, MITOCHONDRIAL GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;translation regulator activity#GO:0045182;nucleic acid binding#GO:0003676;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;translation regulator activity, nucleic acid binding#GO:0090079;translation elongation factor activity#GO:0003746;translation factor activity, RNA binding#GO:0008135 HELRO|EnsemblGenome=HelroG188039|UniProtKB=T1FPK6 T1FPK6 20210753 PTHR32122:SF1 TATA BOX-BINDING PROTEIN ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT A TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT A General transcription by RNA polymerase I#P00022>TAF-IA#P00651;General transcription by RNA polymerase I#P00022>SL1 complex#P00653 HELRO|EnsemblGenome=HelroG137446|UniProtKB=T1EIK9 T1EIK9 20196409 PTHR44500:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 12 DNAJ HOMOLOG SUBFAMILY C MEMBER 12 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG193195|UniProtKB=T1FUQ6 T1FUQ6 20212552 PTHR13484:SF0 FIP1-LIKE 1 PROTEIN PRE-MRNA 3'-END-PROCESSING FACTOR FIP1 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;mRNA cleavage factor complex#GO:0005849;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG112326|UniProtKB=T1EFI7 T1EFI7 20195339 PTHR14604:SF4 WD40 REPEAT PF20 F-BOX DOMAIN-CONTAINING PROTEIN microtubule or microtubule-binding cytoskeletal protein#PC00157 Hedgehog signaling pathway#P00025>Slimb#P00683;Wnt signaling pathway#P00057>betaTrCP#P01454 HELRO|EnsemblGenome=HelroG177055|UniProtKB=T1FB66 T1FB66 20206065 PTHR23304:SF183 SPOT2-RELATED T. BRUCEI SPP.-SPECIFIC PROTEIN HELRO|EnsemblGenome=HelroG189911|UniProtKB=T1FRH2 T1FRH2 20211419 PTHR13003:SF2 NUP107-RELATED NUCLEAR PORE COMPLEX PROTEIN NUP107 structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;protein localization to nucleus#GO:0034504;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;RNA localization#GO:0006403;organic substance transport#GO:0071702;protein import into nucleus#GO:0006606;transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000972;establishment of localization#GO:0051234;RNA transport#GO:0050658;protein localization to organelle#GO:0033365;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;mRNA export from nucleus#GO:0006406;macromolecule biosynthetic process#GO:0009059;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;mRNA transport#GO:0051028;cellular process#GO:0009987;post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000973;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;cellular macromolecule localization#GO:0070727;nuclear export#GO:0051168;nucleocytoplasmic transport#GO:0006913;organelle organization#GO:0006996;chromosome organization#GO:0051276;nucleobase-containing compound transport#GO:0015931;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;import into nucleus#GO:0051170 envelope#GO:0031975;nuclear pore#GO:0005643;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG143589|UniProtKB=T1EJA8 T1EJA8 20196658 PTHR47978:SF40 FAMILY NOT NAMED RAS-RELATED PROTEIN RAB-33 GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG104681|UniProtKB=T1EDN0 T1EDN0 20194682 PTHR18929:SF240 PROTEIN DISULFIDE ISOMERASE PROTEIN DISULFIDE-ISOMERASE isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;protein disulfide isomerase activity#GO:0003756 cellular response to stimulus#GO:0051716;macromolecule biosynthetic process#GO:0009059;response to endoplasmic reticulum stress#GO:0034976;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;response to stress#GO:0006950;protein folding#GO:0006457;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG190227|UniProtKB=T1FRS7 T1FRS7 20211524 PTHR14130:SF14 3BP-1 RELATED RHOGAP RHO GTPASE-ACTIVATING PROTEIN 92B nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of cytoskeleton organization#GO:0051493;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;regulation of organelle organization#GO:0033043;regulation of signaling#GO:0023051;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of cellular component organization#GO:0051128;regulation of actin filament-based process#GO:0032970;regulation of intracellular signal transduction#GO:1902531;regulation of small GTPase mediated signal transduction#GO:0051056 cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 G-protein modulator#PC00022;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG74006|UniProtKB=T1G1L0 T1G1L0 20214958 PTHR12890:SF0 DREV PROTEIN PROTEIN-L-HISTIDINE N-PROS-METHYLTRANSFERASE HELRO|EnsemblGenome=HelroG77153|UniProtKB=T1G2T6 T1G2T6 20215384 PTHR24044:SF488 NOTCH LIGAND FAMILY MEMBER NEUROGENIC LOCUS PROTEIN DELTA protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 intercellular signal molecule#PC00207 Notch signaling pathway#P00045>Delta#P01116;Angiogenesis#P00005>Delta/Serrate#P00226 HELRO|EnsemblGenome=HelroG172826|UniProtKB=T1F5Z4 T1F5Z4 20204243 PTHR11388:SF142 ORGANIC ANION TRANSPORTER SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 5A1 secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;organic substance transport#GO:0071702;establishment of localization#GO:0051234;organic anion transport#GO:0015711;transport#GO:0006810 basal plasma membrane#GO:0009925;basolateral plasma membrane#GO:0016323;plasma membrane region#GO:0098590;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;basal part of cell#GO:0045178;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG190486|UniProtKB=T1FS13 T1FS13 20211610 PTHR23104:SF17 MULTIPLE COAGULATION FACTOR DEFICIENCY PROTEIN 2 NEURAL STEM CELL DERIVED NEURONAL SURVIVAL PROTEIN EF-HAND DOMAIN-CONTAINING PROTEIN membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG114533|UniProtKB=T1EG26 T1EG26 20195528 PTHR18806:SF4 RBM25 PROTEIN RNA-BINDING PROTEIN 25 HELRO|EnsemblGenome=HelroG182104|UniProtKB=T1FHR5 T1FHR5 20208364 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180063|UniProtKB=T1FFF5 T1FFF5 20207554 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194551|UniProtKB=T1FW68 T1FW68 20213064 PTHR11139:SF1 ATAXIA TELANGIECTASIA MUTATED ATM -RELATED TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA biosynthetic process#GO:2001141;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;regulation of DNA-templated transcription#GO:0006355;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;primary metabolic process#GO:0044238;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;regulation of cellular biosynthetic process#GO:0031326;response to stress#GO:0006950;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;cellular response to stress#GO:0033554;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;DNA metabolic process#GO:0006259 SAGA-type complex#GO:0070461;peptidase complex#GO:1905368;histone acetyltransferase complex#GO:0000123;nucleus#GO:0005634;acetyltransferase complex#GO:1902493;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;chromatin#GO:0000785;NuA4 histone acetyltransferase complex#GO:0035267;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;chromosome#GO:0005694;SAGA complex#GO:0000124;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG82074|UniProtKB=T1G4M5 T1G4M5 20216023 PTHR45834:SF3 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9-RELATED RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 3, ISOFORM L nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG80277|UniProtKB=T1G3Z3 T1G3Z3 20215791 PTHR45698:SF1 TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG191975|UniProtKB=T1FTH2 T1FTH2 20212119 PTHR25462:SF305 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG171011|UniProtKB=T1F3P5 T1F3P5 20203444 PTHR45703:SF8 DYNEIN HEAVY CHAIN DYNEINS HEAVY CHAIN microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG65285|UniProtKB=T1FY54 T1FY54 20213752 PTHR19302:SF14 GAMMA TUBULIN COMPLEX PROTEIN GAMMA-TUBULIN COMPLEX COMPONENT 3 cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;meiotic cell cycle#GO:0051321;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule polymerization or depolymerization#GO:0031109;chromosome segregation#GO:0007059;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;reproduction#GO:0000003;microtubule polymerization#GO:0046785;microtubule-based process#GO:0007017;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;supramolecular fiber organization#GO:0097435;sexual reproduction#GO:0019953;protein polymerization#GO:0051258;spindle assembly#GO:0051225;reproductive process#GO:0022414;cell cycle#GO:0007049;cytoskeleton organization#GO:0007010;spindle organization#GO:0007051;non-membrane-bounded organelle assembly#GO:0140694;microtubule nucleation#GO:0007020;cytoplasmic microtubule organization#GO:0031122 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG111877|UniProtKB=T1EFF3 T1EFF3 20195305 PTHR16525:SF0 PROTEIN C12ORF4 PROTEIN C12ORF4 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG164398|UniProtKB=T1EVD8 T1EVD8 20200538 PTHR11927:SF9 GALACTOSIDE 2-L-FUCOSYLTRANSFERASE L-FUCOSYLTRANSFERASE transferase activity#GO:0016740;fucosyltransferase activity#GO:0008417;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein glycosylation#GO:0006486;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycosylation#GO:0070085;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG85898|UniProtKB=T1G640 T1G640 20216537 PTHR11434:SF0 NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transporter complex#GO:1990351;oxidoreductase complex#GO:1990204;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;respirasome#GO:0070469;mitochondrial respiratory chain complex I#GO:0005747;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;transmembrane transporter complex#GO:1902495;mitochondrial respirasome#GO:0005746;membrane-bounded organelle#GO:0043227;respiratory chain complex I#GO:0045271;NADH dehydrogenase complex#GO:0030964;mitochondrial protein-containing complex#GO:0098798 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG168783|UniProtKB=T1F0Y7 T1F0Y7 20202487 PTHR24408:SF58 ZINC FINGER PROTEIN TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG74350|UniProtKB=T1G1P9 T1G1P9 20214997 PTHR23359:SF234 NUCLEOTIDE KINASE ADENYLATE KINASE 2, MITOCHONDRIAL transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, phosphate group as acceptor#GO:0016776;catalytic activity#GO:0003824;kinase activity#GO:0016301 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 nucleotide kinase#PC00172;kinase#PC00137 De novo purine biosynthesis#P02738>Adenylate kinase#P02896 HELRO|EnsemblGenome=HelroG108850|UniProtKB=T1EEN0 T1EEN0 20195032 PTHR45688:SF13 FAMILY NOT NAMED ALANINE--GLYOXYLATE AMINOTRANSFERASE 2-LIKE cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 Pyruvate metabolism#P02772>Aminotransefrase#P03134 HELRO|EnsemblGenome=HelroG175753|UniProtKB=T1F9M2 T1F9M2 20205521 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177164|UniProtKB=T1FBA8 T1FBA8 20206107 PTHR31797:SF6 EXTRACELLULAR MATRIX PROTEIN A-RELATED CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182056|UniProtKB=T1FHN9 T1FHN9 20208338 PTHR19282:SF516 TETRASPANIN TETRASPANIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG72568|UniProtKB=T1G120 T1G120 20214768 PTHR24637:SF388 COLLAGEN NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG120022|UniProtKB=T1EGP3 T1EGP3 20195743 PTHR24179:SF29 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12 LD46604P phosphatase regulator activity#GO:0019208;enzyme inhibitor activity#GO:0004857;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG194436|UniProtKB=T1FW19 T1FW19 20213015 PTHR46848:SF1 REGULATOR OF G-PROTEIN SIGNALING 3 REGULATOR OF G-PROTEIN SIGNALING 3 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731 HELRO|EnsemblGenome=HelroG186086|UniProtKB=T1FNN0 T1FNN0 20210427 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194084|UniProtKB=T1FVN4 T1FVN4 20212880 PTHR38537:SF8 JITTERBUG, ISOFORM N FILAMIN-A HELRO|EnsemblGenome=HelroG98446|UniProtKB=T1G9M8 T1G9M8 20217774 PTHR14986:SF4 RURM1 PROTEIN UBIQUITIN-RELATED MODIFIER 1 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185381|UniProtKB=T1FMQ9 T1FMQ9 20210108 PTHR12753:SF0 AD-003 - RELATED ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1 methyltransferase activity#GO:0008168;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG75296|UniProtKB=T1G234 T1G234 20215132 PTHR13544:SF0 SELENOPROTEIN T THIOREDOXIN REDUCTASE-LIKE SELENOPROTEIN T protein-disulfide reductase activity#GO:0015035;disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;antioxidant activity#GO:0016209;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 homeostatic process#GO:0042592;cellular homeostasis#GO:0019725 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG97107|UniProtKB=T1G9F5 T1G9F5 20217702 PTHR42693:SF49 ARYLSULFATASE FAMILY MEMBER SULFATASE N-TERMINAL DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG177698|UniProtKB=T1FC35 T1FC35 20206384 PTHR12837:SF15 POLY ADP-RIBOSE GLYCOHYDROLASE POLY(ADP-RIBOSE) GLYCOHYDROLASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 ribonucleoside triphosphate metabolic process#GO:0009199;cellular aromatic compound metabolic process#GO:0006725;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative metabolic process#GO:1901135;regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA metabolic process#GO:0051052;regulation of DNA repair#GO:0006282;nucleotide-sugar metabolic process#GO:0009225;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;regulation of cellular response to stress#GO:0080135;organic cyclic compound metabolic process#GO:1901360;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule metabolic process#GO:0043170;purine ribonucleoside triphosphate metabolic process#GO:0009205;regulation of response to stress#GO:0080134;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;regulation of response to stimulus#GO:0048583;regulation of primary metabolic process#GO:0080090;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;purine nucleoside triphosphate metabolic process#GO:0009144;nucleotide metabolic process#GO:0009117;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosidase#PC00110;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG161938|UniProtKB=T1ES20 T1ES20 20199370 PTHR10891:SF918 EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN CALCIUM-BINDING PROTEIN 2 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG186049|UniProtKB=T1FNL5 T1FNL5 20210412 PTHR13093:SF0 ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1 ZGC:112524 nucleosome binding#GO:0031491;protein-containing complex binding#GO:0044877;binding#GO:0005488;chromatin binding#GO:0003682 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;chromatin#GO:0000785;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;INO80-type complex#GO:0097346;cellular anatomical entity#GO:0110165;SWI/SNF superfamily-type complex#GO:0070603;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;histone deacetylase complex#GO:0000118;nuclear lumen#GO:0031981;Swr1 complex#GO:0000812;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG162594|UniProtKB=T1ESW2 T1ESW2 20199662 PTHR15002:SF0 RIBOSOMAL BIOGENESIS PROTEIN LAS1L RIBOSOMAL BIOGENESIS PROTEIN LAS1L cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of 5.8S rRNA#GO:0000460;maturation of LSU-rRNA#GO:0000470;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;preribosome, large subunit precursor#GO:0030687;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG138706|UniProtKB=T1EIW8 T1EIW8 20196518 PTHR19290:SF164 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED BHLH DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;neurogenesis#GO:0022008;positive regulation of RNA biosynthetic process#GO:1902680;cell projection organization#GO:0030030;regulation of nitrogen compound metabolic process#GO:0051171;animal organ development#GO:0048513;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;regulation of biological process#GO:0050789;system development#GO:0048731;cell differentiation#GO:0030154;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;neuron differentiation#GO:0030182;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;multicellular organism development#GO:0007275;cellular component organization#GO:0016043;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;anatomical structure development#GO:0048856;biological regulation#GO:0065007;neuron development#GO:0048666;multicellular organismal process#GO:0032501;positive regulation of RNA metabolic process#GO:0051254;generation of neurons#GO:0048699;sensory organ development#GO:0007423;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG178380|UniProtKB=T1FD42 T1FD42 20206741 PTHR13044:SF14 ACTIVATING TRANSCRIPTION FACTOR ATF 4/5 CRYPTOCEPHAL, ISOFORM A DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG186220|UniProtKB=T1FNU0 T1FNU0 20210487 PTHR12452:SF0 42-9-9 PROTEIN-RELATED THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17 protein-disulfide reductase activity#GO:0015035;disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG184572|UniProtKB=T1FLI1 T1FLI1 20209680 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG187950|UniProtKB=T1FPI0 T1FPI0 20210727 PTHR11905:SF159 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG86528|UniProtKB=T1G6D5 T1G6D5 20216632 PTHR16515:SF66 PR DOMAIN ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG161224|UniProtKB=T1ER84 T1ER84 20199084 PTHR11506:SF35 LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 5 localization#GO:0051179;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;protein localization to organelle#GO:0033365;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 bounding membrane of organelle#GO:0098588;lytic vacuole membrane#GO:0098852;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vacuolar membrane#GO:0005774;late endosome membrane#GO:0031902;vacuole#GO:0005773;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endosome membrane#GO:0010008;lytic vacuole#GO:0000323;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;lysosomal membrane#GO:0005765;lysosome#GO:0005764;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG71226|UniProtKB=T1G0I0 T1G0I0 20214578 PTHR10605:SF72 HEPARAN SULFATE SULFOTRANSFERASE HEPARAN SULFATE 3-O SULFOTRANSFERASE-B, ISOFORM A sulfotransferase activity#GO:0008146;transferase activity#GO:0016740;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity#GO:0003824 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG80670|UniProtKB=T1G437 T1G437 20215835 PTHR15036:SF85 PIKACHURIN-LIKE PROTEIN SP2353, ISOFORM A cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG155932|UniProtKB=T1ELP4 T1ELP4 20197494 PTHR12544:SF29 GLUTAMINASE GLUTAMINASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824 dicarboxylic acid metabolic process#GO:0043648;proteinogenic amino acid biosynthetic process#GO:0170038;organonitrogen compound catabolic process#GO:1901565;biosynthetic process#GO:0009058;carboxylic acid biosynthetic process#GO:0046394;amino acid catabolic process#GO:0009063;nitrogen compound metabolic process#GO:0006807;glutamate metabolic process#GO:0006536;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;L-amino acid metabolic process#GO:0170033;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248;organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;alpha-amino acid biosynthetic process#GO:1901607;L-amino acid biosynthetic process#GO:0170034;small molecule biosynthetic process#GO:0044283;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG160635|UniProtKB=T1EQJ1 T1EQJ1 20198841 PTHR16290:SF0 TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1 DECAPPING PROTEIN 1, ISOFORM A RNA binding#GO:0003723;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 negative regulation of gene expression#GO:0010629;regulation of catabolic process#GO:0009894;heterocycle catabolic process#GO:0046700;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;nucleobase-containing compound metabolic process#GO:0006139;RNA destabilization#GO:0050779;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;regulation of biological quality#GO:0065008;nitrogen compound metabolic process#GO:0006807;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;positive regulation of mRNA catabolic process#GO:0061014;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of catabolic process#GO:0009896;mRNA destabilization#GO:0061157;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323;positive regulation of nitrogen compound metabolic process#GO:0051173;cellular aromatic compound metabolic process#GO:0006725;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;RNA metabolic process#GO:0016070;positive regulation of cellular catabolic process#GO:0031331;cellular nitrogen compound catabolic process#GO:0044270;RNA decapping#GO:0110154;organic cyclic compound metabolic process#GO:1901360;positive regulation of metabolic process#GO:0009893;mRNA catabolic process#GO:0006402;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;positive regulation of mRNA metabolic process#GO:1903313;heterocycle metabolic process#GO:0046483;negative regulation of biosynthetic process#GO:0009890;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of cellular catabolic process#GO:0031329;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;positive regulation of RNA metabolic process#GO:0051254 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;P-body#GO:0000932;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic ribonucleoprotein granule#GO:0036464 RNA processing factor#PC00147;mRNA capping factor#PC00145 TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282 HELRO|EnsemblGenome=HelroG155584|UniProtKB=T1ELJ2 T1ELJ2 20197442 PTHR10705:SF0 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 membrane protein complex#GO:0098796;endoplasmic reticulum protein-containing complex#GO:0140534;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;oligosaccharyltransferase complex#GO:0008250;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG89246|UniProtKB=T1G7A9 T1G7A9 20216956 PTHR11003:SF334 POTASSIUM CHANNEL, SUBFAMILY K FI03418P monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG166355|UniProtKB=T1EY18 T1EY18 20201468 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159191|UniProtKB=T1ENQ3 T1ENQ3 20198203 PTHR13143:SF6 TETRATRICOPEPTIDE REPEAT PROTEIN 19 TETRATRICOPEPTIDE REPEAT PROTEIN 19, MITOCHONDRIAL cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrial respiratory chain complex III assembly#GO:0034551;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;cytochrome complex assembly#GO:0017004;protein-containing complex assembly#GO:0065003;mitochondrion organization#GO:0007005;cellular component organization#GO:0016043;cellular process#GO:0009987 envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG156594|UniProtKB=T1ELY8 T1ELY8 20197588 PTHR11359:SF0 AMP DEAMINASE AMP DEAMINASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;deaminase activity#GO:0019239;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;purine ribonucleoside monophosphate metabolic process#GO:0009167;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;nucleotide biosynthetic process#GO:0009165;nucleoside monophosphate metabolic process#GO:0009123;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;IMP metabolic process#GO:0046040;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;purine nucleoside monophosphate metabolic process#GO:0009126;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribonucleoside monophosphate metabolic process#GO:0009161;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;IMP biosynthetic process#GO:0006188;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 deaminase#PC00088;hydrolase#PC00121 Purine metabolism#P02769>5'-AMP Deaminase#P03117 HELRO|EnsemblGenome=HelroG81043|UniProtKB=T1G482 T1G482 20215880 PTHR12859:SF0 PRA1 PROTEIN PRA1 FAMILY PROTEIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 amino acid transporter#PC00046;secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG172409|UniProtKB=T1F5A3 T1F5A3 20204002 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG186833|UniProtKB=T1FP40 T1FP40 20210587 PTHR11349:SF111 NUCLEOSIDE DIPHOSPHATE KINASE NUCLEOSIDE DIPHOSPHATE KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;nucleoside diphosphate kinase activity#GO:0004550;phosphotransferase activity, phosphate group as acceptor#GO:0016776;catalytic activity#GO:0003824;kinase activity#GO:0016301 transferase#PC00220;kinase#PC00137;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG69050|UniProtKB=T1FZN7 T1FZN7 20214285 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG74707|UniProtKB=T1G1U7 T1G1U7 20215045 PTHR19143:SF444 FIBRINOGEN/TENASCIN/ANGIOPOEITIN PROTEIN SCABROUS external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG194746|UniProtKB=T1FWD2 T1FWD2 20213127 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG172823|UniProtKB=T1F5Z2 T1F5Z2 20204241 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG116278|UniProtKB=T1EGD9 T1EGD9 20195641 PTHR31993:SF4 UBA-LIKE DOMAIN-CONTAINING PROTEIN 2 UBA-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77464|UniProtKB=T1G2Y2 T1G2Y2 20215430 PTHR10983:SF73 1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE EPSILON transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;glycerolipid metabolic process#GO:0046486;cellular metabolic process#GO:0044237;phosphatidylinositol metabolic process#GO:0046488;organophosphate metabolic process#GO:0019637;glycerophospholipid metabolic process#GO:0006650;cellular process#GO:0009987;phospholipid metabolic process#GO:0006644;cellular lipid metabolic process#GO:0044255;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG165061|UniProtKB=T1EW83 T1EW83 20200833 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG94925|UniProtKB=T1G940 T1G940 20217587 PTHR43294:SF13 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium ion transmembrane transporter activity#GO:0015079;sodium ion transmembrane transporter activity#GO:0015081;P-type ion transporter activity#GO:0015662;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075 inorganic ion homeostasis#GO:0098771;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;proton transmembrane transport#GO:1902600;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;sodium ion homeostasis#GO:0055078;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;import into cell#GO:0098657;monoatomic cation transmembrane transport#GO:0098655;export from cell#GO:0140352;sodium ion transmembrane transport#GO:0035725;potassium ion import across plasma membrane#GO:1990573;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG119837|UniProtKB=T1EGN7 T1EGN7 20195737 PTHR10217:SF435 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EAG monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG192271|UniProtKB=T1FTS3 T1FTS3 20212220 PTHR31658:SF0 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG156740|UniProtKB=T1EM05 T1EM05 20197605 PTHR23235:SF150 KRUEPPEL-LIKE TRANSCRIPTION FACTOR KRUEPPEL-LIKE FACTOR LUNA sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG184984|UniProtKB=T1FM82 T1FM82 20209931 PTHR47385:SF14 CALPONIN TRANSGELIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG84043|UniProtKB=T1G5D8 T1G5D8 20216285 PTHR11785:SF516 AMINO ACID TRANSPORTER AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN L-amino acid transmembrane transporter activity#GO:0015179;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;amino acid transport#GO:0006865;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;nitrogen compound transport#GO:0071705;organic acid transmembrane transport#GO:1903825;carboxylic acid transport#GO:0046942;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039 transporter#PC00227 HELRO|EnsemblGenome=HelroG181244|UniProtKB=T1FGS4 T1FGS4 20208023 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185935|UniProtKB=T1FNG5 T1FNG5 20210362 PTHR13693:SF102 CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE 2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL transaminase#PC00216;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG108931|UniProtKB=T1EEN9 T1EEN9 20195041 PTHR42687:SF1 L-THREONINE 3-DEHYDROGENASE L-THREONINE 3-DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;amino acid catabolic process#GO:0009063;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;nitrogen compound metabolic process#GO:0006807;alpha-amino acid metabolic process#GO:1901605;catabolic process#GO:0009056;aspartate family amino acid metabolic process#GO:0009066;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;L-amino acid metabolic process#GO:0170033;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG69268|UniProtKB=T1FZS4 T1FZS4 20214322 PTHR10694:SF33 LYSINE-SPECIFIC DEMETHYLASE LYSINE-SPECIFIC DEMETHYLASE 5 histone modifying activity#GO:0140993;demethylase activity#GO:0032451;catalytic activity, acting on a protein#GO:0140096;histone demethylase activity#GO:0032452;catalytic activity#GO:0003824 protein-DNA complex organization#GO:0071824;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;protein-containing complex organization#GO:0043933;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG73057|UniProtKB=T1G193 T1G193 20214841 PTHR18063:SF6 NF-E2 INDUCIBLE PROTEIN UBIQUITIN CARBOXYL-TERMINAL HYDROLASE cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;carboxypeptidase activity#GO:0004180 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein K48-linked deubiquitination#GO:0071108;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG72794|UniProtKB=T1G157 T1G157 20214805 PTHR31640:SF1 TRANSMEMBRANE PROTEIN KIAA1109 BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 1 HELRO|EnsemblGenome=HelroG160033|UniProtKB=T1EPP4 T1EPP4 20198544 PTHR46273:SF4 MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED AT19640P signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG192693|UniProtKB=T1FU73 T1FU73 20212369 PTHR23152:SF4 2-OXOGLUTARATE DEHYDROGENASE 2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 TCA cycle#P00051>alphaketoglutarate Dehydrogenase#P01269 HELRO|EnsemblGenome=HelroG188273|UniProtKB=T1FPT7 T1FPT7 20210834 PTHR10809:SF6 VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN AT11025P-RELATED localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organelle localization#GO:0051640;endoplasmic reticulum organization#GO:0007029;membrane organization#GO:0061024;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;plasma membrane#GO:0005886;endoplasmic reticulum membrane#GO:0005789 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG105374|UniProtKB=T1EDU2 T1EDU2 20194744 PTHR19961:SF18 FIMBRIN/PLASTIN FI19014P1 cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament bundle assembly#GO:0051017;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;actin filament bundle organization#GO:0061572;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;actin filament bundle#GO:0032432;actin cytoskeleton#GO:0015629;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;actin filament#GO:0005884;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG140970|UniProtKB=T1EJ22 T1EJ22 20196572 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-LIKE 1 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;localization#GO:0051179;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 membrane protein complex#GO:0098796;synapse#GO:0045202;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron projection#GO:0043005;transmembrane transporter complex#GO:1902495;cell projection#GO:0042995;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HELRO|EnsemblGenome=HelroG111616|UniProtKB=T1EFC9 T1EFC9 20195281 PTHR48038:SF1 RIBONUCLEOPROTEIN RB97D RIBONUCLEOPROTEIN RB97D HELRO|EnsemblGenome=HelroG71528|UniProtKB=T1G0M7 T1G0M7 20214625 PTHR24244:SF1 NEUROPEPTIDE S RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG190084|UniProtKB=T1FRN9 T1FRN9 20211486 PTHR48021:SF1 FAMILY NOT NAMED GH07001P-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG103352|UniProtKB=T1EDF7 T1EDF7 20194609 PTHR11815:SF1 SUCCINYL-COA SYNTHETASE BETA CHAIN SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL ligase activity#GO:0016874;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;sulfur compound metabolic process#GO:0006790;nucleobase-containing compound metabolic process#GO:0006139;energy derivation by oxidation of organic compounds#GO:0015980;phosphorus metabolic process#GO:0006793;tricarboxylic acid cycle#GO:0006099;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;amide metabolic process#GO:0043603;purine nucleotide metabolic process#GO:0006163;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;heterocycle metabolic process#GO:0046483;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;acyl-CoA metabolic process#GO:0006637;generation of precursor metabolites and energy#GO:0006091;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;ribonucleotide metabolic process#GO:0009259;primary metabolic process#GO:0044238;purine ribonucleotide metabolic process#GO:0009150;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG75990|UniProtKB=T1G2D6 T1G2D6 20215234 PTHR46021:SF2 ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1 nucleoside-triphosphatase regulator activity#GO:0060589;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;small molecule binding#GO:0036094;binding#GO:0005488;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047;lipid binding#GO:0008289;anion binding#GO:0043168;phosphatidylinositol binding#GO:0035091;ion binding#GO:0043167;phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981;enzyme regulator activity#GO:0030234 biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;regulation of GTPase activity#GO:0043087;regulation of molecular function#GO:0065009 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG120372|UniProtKB=T1EGP8 T1EGP8 20195748 PTHR23082:SF0 TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;transcription by RNA polymerase III#GO:0006383;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;transcription factor TFIIIC complex#GO:0000127 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG157558|UniProtKB=T1EMD1 T1EMD1 20197731 PTHR23064:SF72 TROPONIN TROPONIN C, SKELETAL MUSCLE cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG164995|UniProtKB=T1EW33 T1EW33 20200783 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165664|UniProtKB=T1EX54 T1EX54 20201154 PTHR20908:SF1 LD15586P LD15586P hydrolase activity#GO:0016787;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171 HELRO|EnsemblGenome=HelroG192861|UniProtKB=T1FUD4 T1FUD4 20212430 PTHR27001:SF931 OS01G0253100 PROTEIN OS11G0664100 PROTEIN macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG99711|UniProtKB=T1G9U6 T1G9U6 20217842 PTHR10288:SF321 KH DOMAIN CONTAINING RNA BINDING PROTEIN MUSHROOM-BODY EXPRESSED, ISOFORM K nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nitrogen compound metabolic process#GO:0051171;regulation of biosynthetic process#GO:0009889;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG70587|UniProtKB=T1G089 T1G089 20214487 PTHR12499:SF0 OPTIC ATROPHY 3 PROTEIN OPA3 OPTIC ATROPHY 3 PROTEIN biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of lipid metabolic process#GO:0019216;regulation of metabolic process#GO:0019222 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG190484|UniProtKB=T1FS11 T1FS11 20211608 PTHR33538:SF1 PROTEIN GAMETE EXPRESSED 1 PROTEIN BRAMBLEBERRY HELRO|EnsemblGenome=HelroG64605|UniProtKB=T1FXW9 T1FXW9 20213667 PTHR24241:SF76 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR NEUROPEPTIDE SIFAMIDE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;binding#GO:0005488;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888;amide binding#GO:0033218 response to organic substance#GO:0010033;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;response to hormone#GO:0009725;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG163169|UniProtKB=T1ETR2 T1ETR2 20199962 PTHR42753:SF9 MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER LARGE RIBOSOMAL SUBUNIT PROTEIN ML39 catalytic activity, acting on RNA#GO:0140098;ligase activity#GO:0016874;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG183498|UniProtKB=T1FJR7 T1FJR7 20209066 PTHR48017:SF206 OS05G0424000 PROTEIN-RELATED VESICULAR INHIBITORY AMINO ACID TRANSPORTER HELRO|EnsemblGenome=HelroG132346|UniProtKB=T1EHY0 T1EHY0 20196180 PTHR10694:SF129 LYSINE-SPECIFIC DEMETHYLASE LYSINE-SPECIFIC DEMETHYLASE 4B-RELATED histone modifying activity#GO:0140993;demethylase activity#GO:0032451;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;histone demethylase activity#GO:0032452;catalytic activity#GO:0003824;dioxygenase activity#GO:0051213;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491 protein-DNA complex organization#GO:0071824;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;protein-containing complex organization#GO:0043933;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG111100|UniProtKB=T1EF81 T1EF81 20195233 PTHR10694:SF129 LYSINE-SPECIFIC DEMETHYLASE LYSINE-SPECIFIC DEMETHYLASE 4B-RELATED histone modifying activity#GO:0140993;demethylase activity#GO:0032451;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;histone demethylase activity#GO:0032452;catalytic activity#GO:0003824;dioxygenase activity#GO:0051213;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491 protein-DNA complex organization#GO:0071824;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;protein-containing complex organization#GO:0043933;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG72278|UniProtKB=T1G0X9 T1G0X9 20214727 PTHR35577:SF2 CYSTEINE-RICH, ACIDIC INTEGRAL MEMBRANE PROTEIN-RELATED DYNEIN HEAVY CHAIN HELRO|EnsemblGenome=HelroG171080|UniProtKB=T1F3S9 T1F3S9 20203478 PTHR11360:SF251 MONOCARBOXYLATE TRANSPORTER MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN transporter#PC00227 HELRO|EnsemblGenome=HelroG95235|UniProtKB=T1G952 T1G952 20217599 PTHR24034:SF89 EGF-LIKE DOMAIN-CONTAINING PROTEIN COMPLEMENT COMPONENT C1Q RECEPTOR extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG178838|UniProtKB=T1FDT4 T1FDT4 20206983 PTHR10003:SF77 SUPEROXIDE DISMUTASE CU-ZN -RELATED EXTRACELLULAR SUPEROXIDE DISMUTASE [CU-ZN] cation binding#GO:0043169;antioxidant activity#GO:0016209;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;copper ion binding#GO:0005507;metal ion binding#GO:0046872;ion binding#GO:0043167;oxidoreductase activity#GO:0016491 cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;cellular metabolic process#GO:0044237;response to oxidative stress#GO:0006979;cellular process#GO:0009987;response to stimulus#GO:0050896;cellular response to oxygen-containing compound#GO:1901701;detoxification#GO:0098754;response to stress#GO:0006950;response to chemical#GO:0042221;cellular response to oxidative stress#GO:0034599;response to toxic substance#GO:0009636;response to reactive oxygen species#GO:0000302;cellular response to stress#GO:0033554;metabolic process#GO:0008152 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG81165|UniProtKB=T1G4A4 T1G4A4 20215902 PTHR35684:SF2 FAMILY NOT NAMED SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG181678|UniProtKB=T1FH82 T1FH82 20208181 PTHR19890:SF10 FIBROBLAST GROWTH FACTOR RECEPTOR FIBROBLAST GROWTH FACTOR RECEPTOR-LIKE 1 transmembrane signal receptor#PC00197;tyrosine protein kinase receptor#PC00233 HELRO|EnsemblGenome=HelroG71572|UniProtKB=T1G0N6 T1G0N6 20214634 PTHR32100:SF35 OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC DELTA(12) FATTY ACID DESATURASE FAT-2 oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG159628|UniProtKB=T1EP94 T1EP94 20198394 PTHR12064:SF97 METAL TRANSPORTER CNNM METAL TRANSPORTER CNNM-5 inorganic ion homeostasis#GO:0098771;intracellular monoatomic cation homeostasis#GO:0030003;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic ion homeostasis#GO:0006873;chemical homeostasis#GO:0048878;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG189098|UniProtKB=T1FQN0 T1FQN0 20211127 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG163554|UniProtKB=T1EU74 T1EU74 20200124 PTHR13800:SF12 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER-LIKE 2 calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;calcium ion transmembrane transport#GO:0070588;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;calcium ion transport#GO:0006816 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG76395|UniProtKB=T1G2J6 T1G2J6 20215294 PTHR23055:SF178 CALCIUM BINDING PROTEINS NEUROCALCIN HOMOLOG cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG68427|UniProtKB=T1FZE5 T1FZE5 20214193 PTHR43245:SF11 BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA LD23561P HELRO|EnsemblGenome=HelroG188060|UniProtKB=T1FPL2 T1FPL2 20210759 PTHR24243:SF233 G-PROTEIN COUPLED RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG70153|UniProtKB=T1G030 T1G030 20214428 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157191|UniProtKB=T1EM77 T1EM77 20197677 PTHR11264:SF0 URACIL-DNA GLYCOSYLASE URACIL-DNA GLYCOSYLASE catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity, acting on DNA#GO:0140097;DNA N-glycosylase activity#GO:0019104;catalytic activity#GO:0003824 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;base-excision repair#GO:0006284;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;DNA damage response#GO:0006974;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 DNA glycosylase#PC00010 HELRO|EnsemblGenome=HelroG173491|UniProtKB=T1F6V9 T1F6V9 20204558 PTHR19957:SF307 SYNTAXIN PROTEIN SSO1-RELATED molecular adaptor activity#GO:0060090;protein binding#GO:0005515;SNAP receptor activity#GO:0005484;binding#GO:0005488;SNARE binding#GO:0000149;protein-macromolecule adaptor activity#GO:0030674 vesicle fusion#GO:0006906;cellular localization#GO:0051641;organelle localization#GO:0051640;macromolecule localization#GO:0033036;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;membrane fusion#GO:0061025;exocytosis#GO:0006887;establishment of localization#GO:0051234;organelle organization#GO:0006996;secretion#GO:0046903;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;vesicle organization#GO:0016050;intracellular transport#GO:0046907;export from cell#GO:0140352;secretion by cell#GO:0032940;organelle fusion#GO:0048284 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;SNARE complex#GO:0031201;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034;membrane traffic protein#PC00150 Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079 HELRO|EnsemblGenome=HelroG183969|UniProtKB=T1FKD6 T1FKD6 20209285 PTHR13906:SF4 PORCUPINE LYSOPHOSPHOLIPID ACYLTRANSFERASE 6 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;cellular metabolic process#GO:0044237;lipid modification#GO:0030258;cellular lipid metabolic process#GO:0044255;cellular process#GO:0009987;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transferase#PC00220;acetyltransferase#PC00038;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG74464|UniProtKB=T1G1R4 T1G1R4 20215012 PTHR12861:SF3 TRANSLOCON-ASSOCIATED PROTEIN, BETA SUBUNIT PRECURSOR TRAP-BETA SIGNAL SEQUENCE RECEPTOR BETA SUBUNIT TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT BETA membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG123616|UniProtKB=T1EGY2 T1EGY2 20195832 PTHR11214:SF364 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE HEXOSYLTRANSFERASE transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG192104|UniProtKB=T1FTK5 T1FTK5 20212152 PTHR13161:SF15 SPLICING FACTOR SUPPRESSOR OF WHITE APRICOT SPLICING FACTOR, SUPPRESSOR OF WHITE-APRICOT HOMOLOG cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;mRNA cis splicing, via spliceosome#GO:0045292;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;mRNA splicing, via spliceosome#GO:0000398;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;mRNA splice site recognition#GO:0006376;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375;spliceosomal complex assembly#GO:0000245 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG160337|UniProtKB=T1EQ41 T1EQ41 20198691 PTHR13891:SF1 CYTOCHROME C OXIDASE ASSEMBLY FACTOR 7 CYTOCHROME C OXIDASE ASSEMBLY FACTOR 7 HELRO|EnsemblGenome=HelroG164071|UniProtKB=T1EUV6 T1EUV6 20200356 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189840|UniProtKB=T1FRE8 T1FRE8 20211395 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG175371|UniProtKB=T1F973 T1F973 20205372 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167609|UniProtKB=T1EZJ8 T1EZJ8 20201998 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG188325|UniProtKB=T1FPV8 T1FPV8 20210855 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG192148|UniProtKB=T1FTM7 T1FTM7 20212174 PTHR30109:SF0 HYDROXYLAMINE REDUCTASE HYDROXYLAMINE REDUCTASE oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;antioxidant activity#GO:0016209;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 response to stimulus#GO:0050896;response to stress#GO:0006950;response to oxygen-containing compound#GO:1901700;response to chemical#GO:0042221;nitrogen compound metabolic process#GO:0006807;response to reactive oxygen species#GO:0000302;response to oxidative stress#GO:0006979;metabolic process#GO:0008152 reductase#PC00198;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG177290|UniProtKB=T1FBG6 T1FBG6 20206165 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG165414|UniProtKB=T1EWR1 T1EWR1 20201011 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174795|UniProtKB=T1F8H3 T1F8H3 20205122 PTHR35076:SF1 TUBULIN EPSILON AND DELTA COMPLEX PROTEIN 1 TUBULIN EPSILON AND DELTA COMPLEX PROTEIN 1 HELRO|EnsemblGenome=HelroG182017|UniProtKB=T1FHL6 T1FHL6 20208315 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER FI01427P membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG145946|UniProtKB=T1EJP2 T1EJP2 20196792 PTHR33332:SF40 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166778|UniProtKB=T1EYI5 T1EYI5 20201635 PTHR33395:SF21 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED PERICARDIN heart morphogenesis#GO:0003007;system development#GO:0048731;heart development#GO:0007507;circulatory system development#GO:0072359;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;animal organ development#GO:0048513;multicellular organism development#GO:0007275;developmental process#GO:0032502;animal organ morphogenesis#GO:0009887;multicellular organismal process#GO:0032501;cell adhesion#GO:0007155;cellular process#GO:0009987;post-embryonic development#GO:0009791 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG161549|UniProtKB=T1ERL9 T1ERL9 20199219 PTHR16222:SF26 ADP-RIBOSYLGLYCOHYDROLASE ADP-RIBOSYLHYDROLASE ARH1 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG94076|UniProtKB=T1G8Y9 T1G8Y9 20217536 PTHR23180:SF399 CENTAURIN/ARF BLOWN FUSE, ISOFORM A-RELATED HELRO|EnsemblGenome=HelroG182955|UniProtKB=T1FIZ5 T1FIZ5 20208794 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED single-stranded RNA binding#GO:0003727;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;poly(A) binding#GO:0008143;binding#GO:0005488;organic cyclic compound binding#GO:0097159 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG162130|UniProtKB=T1ES96 T1ES96 20199446 PTHR31784:SF2 BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 5 BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 5 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG88095|UniProtKB=T1G6Y4 T1G6Y4 20216831 PTHR24073:SF509 DRAB5-RELATED RAS-RELATED PROTEIN RAB-21 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 localization#GO:0051179;organic substance transport#GO:0071702;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;protein transport#GO:0015031;nitrogen compound transport#GO:0071705;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;early endosome#GO:0005769;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG162556|UniProtKB=T1ESU1 T1ESU1 20199641 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185407|UniProtKB=T1FMS0 T1FMS0 20210119 PTHR45806:SF1 SYNAPTOBREVIN HOMOLOG YKT6 SYNAPTOBREVIN HOMOLOG YKT6 molecular adaptor activity#GO:0060090;SNAP receptor activity#GO:0005484;protein-macromolecule adaptor activity#GO:0030674 localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG109032|UniProtKB=T1EEQ1 T1EEQ1 20195053 PTHR13847:SF193 SARCOSINE DEHYDROGENASE-RELATED PYRUVATE DEHYDROGENASE PHOSPHATASE REGULATORY SUBUNIT, MITOCHONDRIAL cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG69677|UniProtKB=T1FZY0 T1FZY0 20214378 PTHR10942:SF0 LEISHMANOLYSIN-LIKE PEPTIDASE LEISHMANOLYSIN-LIKE PEPTIDASE hydrolase activity#GO:0016787;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG162169|UniProtKB=T1ESB4 T1ESB4 20199464 PTHR11913:SF12 COFILIN-RELATED COFILIN_ACTIN-DEPOLYMERIZING FACTOR HOMOLOG-RELATED cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;cellular component disassembly#GO:0022411;actin filament-based process#GO:0030029;protein-containing complex disassembly#GO:0032984;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;actin polymerization or depolymerization#GO:0008154;cellular component organization#GO:0016043;protein depolymerization#GO:0051261;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;actin filament depolymerization#GO:0030042 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 Cytoskeletal regulation by Rho GTPase#P00016>Cofilin#P00508 HELRO|EnsemblGenome=HelroG115616|UniProtKB=T1EG96 T1EG96 20195598 PTHR48051:SF33 FAMILY NOT NAMED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG80169|UniProtKB=T1G3Y5 T1G3Y5 20215783 PTHR10694:SF7 LYSINE-SPECIFIC DEMETHYLASE [HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE histone modifying activity#GO:0140993;demethylase activity#GO:0032451;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;histone demethylase activity#GO:0032452;catalytic activity#GO:0003824;dioxygenase activity#GO:0051213;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491 protein-DNA complex organization#GO:0071824;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;protein-containing complex organization#GO:0043933;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG184365|UniProtKB=T1FL22 T1FL22 20209521 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG73524|UniProtKB=T1G1F2 T1G1F2 20214900 PTHR23131:SF0 ENDORIBONUCLEASE LACTB2 ENDORIBONUCLEASE LACTB2 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG179495|UniProtKB=T1FES9 T1FES9 20207328 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG108992|UniProtKB=T1EEP7 T1EEP7 20195049 PTHR46803:SF2 E3 UBIQUITIN-PROTEIN LIGASE CHIP E3 UBIQUITIN-PROTEIN LIGASE CHIP transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;protein binding#GO:0005515;aminoacyltransferase activity#GO:0016755;protein-folding chaperone binding#GO:0051087;catalytic activity, acting on a protein#GO:0140096 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of protein metabolic process#GO:0051246;macromolecule modification#GO:0043412;regulation of nitrogen compound metabolic process#GO:0051171;protein catabolic process#GO:0030163;organonitrogen compound catabolic process#GO:1901565;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;positive regulation of proteolysis#GO:0045862;modification-dependent macromolecule catabolic process#GO:0043632;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;positive regulation of biological process#GO:0048518;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;response to organic substance#GO:0010033;regulation of proteolysis#GO:0030162;macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;protein quality control for misfolded or incompletely synthesized proteins#GO:0006515;cellular response to chemical stimulus#GO:0070887;protein modification by small protein conjugation or removal#GO:0070647;macromolecule metabolic process#GO:0043170;cellular response to organic substance#GO:0071310;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;organonitrogen compound metabolic process#GO:1901564;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;cellular response to topologically incorrect protein#GO:0035967;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;positive regulation of protein metabolic process#GO:0051247;response to stress#GO:0006950;response to chemical#GO:0042221;regulation of macromolecule metabolic process#GO:0060255;response to topologically incorrect protein#GO:0035966;biological regulation#GO:0065007;cellular response to stress#GO:0033554;regulation of metabolic process#GO:0019222 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Parkinson disease#P00049>CHIP#P01214 HELRO|EnsemblGenome=HelroG153392|UniProtKB=T1EL66 T1EL66 20197316 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG91040|UniProtKB=T1G7Z0 T1G7Z0 20217187 PTHR10574:SF274 NETRIN/LAMININ-RELATED USHERIN animal organ morphogenesis#GO:0009887;anatomical structure morphogenesis#GO:0009653;tissue development#GO:0009888;anatomical structure development#GO:0048856;animal organ development#GO:0048513;developmental process#GO:0032502 extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG75616|UniProtKB=T1G274 T1G274 20215172 PTHR22998:SF1 SARM1 NAD(+) HYDROLASE SARM1 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185002|UniProtKB=T1FM94 T1FM94 20209943 PTHR10516:SF443 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FK506-BINDING PROTEIN 59-RELATED chaperone#PC00072 TGF-beta signaling pathway#P00052>FKBP12#P01288 HELRO|EnsemblGenome=HelroG177731|UniProtKB=T1FC54 T1FC54 20206403 PTHR23309:SF49 3-HYDROXYACYL-COA DEHYROGENASE PEROXISOMAL BIFUNCTIONAL ENZYME oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;lipid oxidation#GO:0034440;cellular metabolic process#GO:0044237;lipid catabolic process#GO:0016042;lipid modification#GO:0030258;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;fatty acid catabolic process#GO:0009062;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;fatty acid metabolic process#GO:0006631;small molecule catabolic process#GO:0044282;fatty acid beta-oxidation#GO:0006635;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;carboxylic acid metabolic process#GO:0019752;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG157807|UniProtKB=T1EMG1 T1EMG1 20197761 PTHR43725:SF47 UDP-GLUCOSE 4-EPIMERASE UDP-GLUCOSE 4-EPIMERASE racemase and epimerase activity, acting on carbohydrates and derivatives#GO:0016857;isomerase activity#GO:0016853;catalytic activity#GO:0003824 monosaccharide metabolic process#GO:0005996;carbohydrate metabolic process#GO:0005975;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 epimerase/racemase#PC00096;metabolite interconversion enzyme#PC00262 Fructose galactose metabolism#P02744>UDP Glucose 4 epimerase#P02965 HELRO|EnsemblGenome=HelroG86249|UniProtKB=T1G692 T1G692 20216589 PTHR11461:SF372 SERINE PROTEASE INHIBITOR, SERPIN ACCESSORY GLAND PROTEIN ACP76A-RELATED extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG166880|UniProtKB=T1EYP6 T1EYP6 20201696 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG80970|UniProtKB=T1G477 T1G477 20215875 PTHR13693:SF3 CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE LD36009P transaminase#PC00216;transferase#PC00220;metabolite interconversion enzyme#PC00262 Biotin biosynthesis#P02731>8-Amino-7-oxononanoate synthase#P02858 HELRO|EnsemblGenome=HelroG183432|UniProtKB=T1FJN0 T1FJN0 20209029 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171477|UniProtKB=T1F4C2 T1F4C2 20203671 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180531|UniProtKB=T1FG11 T1FG11 20207760 PTHR16021:SF22 MANSC DOMAIN CONTAINING PROTEIN 1 OXIDANT-INDUCED CELL-CYCLE ARREST PROTEIN 5 HELRO|EnsemblGenome=HelroG64136|UniProtKB=T1FXQ0 T1FXQ0 20213598 PTHR11711:SF455 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR 2 carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 G-protein#PC00020 Huntington disease#P00029>ARF#P00786 HELRO|EnsemblGenome=HelroG172012|UniProtKB=T1F4X8 T1F4X8 20203877 PTHR21461:SF87 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GH12965P transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 glycosylation#GO:0070085;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG117034|UniProtKB=T1EGJ5 T1EGJ5 20195697 PTHR19441:SF95 WHEY ACDIC PROTEIN WAP PERLWAPIN ISOFORM X1 peptidase inhibitor activity#GO:0030414;molecular function regulator activity#GO:0098772;serine-type endopeptidase inhibitor activity#GO:0004867;peptidase regulator activity#GO:0061134;enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;endopeptidase regulator activity#GO:0061135;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG188380|UniProtKB=T1FPX8 T1FPX8 20210875 PTHR47020:SF1 HILLARIN HILLARIN HELRO|EnsemblGenome=HelroG101069|UniProtKB=T1ED29 T1ED29 20194481 PTHR11620:SF2 60S RIBOSOMAL PROTEIN L23A 60S RIBOSOMAL PROTEIN L23A structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;organelle assembly#GO:0070925;protein-RNA complex assembly#GO:0022618;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;ribosomal large subunit assembly#GO:0000027;ribonucleoprotein complex biogenesis#GO:0022613;protein-RNA complex organization#GO:0071826;ribosome biogenesis#GO:0042254;non-membrane-bounded organelle assembly#GO:0140694 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG81478|UniProtKB=T1G4E8 T1G4E8 20215946 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG184998|UniProtKB=T1FM91 T1FM91 20209940 PTHR22912:SF151 DISULFIDE OXIDOREDUCTASE DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL nucleotide binding#GO:0000166;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;flavin adenine dinucleotide binding#GO:0050660;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;oxidoreductase activity#GO:0016491 oxoacid metabolic process#GO:0043436;dicarboxylic acid metabolic process#GO:0043648;cellular metabolic process#GO:0044237;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG167069|UniProtKB=T1EYZ0 T1EYZ0 20201790 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG188284|UniProtKB=T1FPT9 T1FPT9 20210836 PTHR22872:SF9 BTK-BINDING PROTEIN-RELATED X-LINKED RETINITIS PIGMENTOSA GTPASE REGULATOR HELRO|EnsemblGenome=HelroG176887|UniProtKB=T1FB07 T1FB07 20206006 PTHR47570:SF1 ZINC ION BINDING PROTEIN ZINC ION BINDING PROTEIN HELRO|EnsemblGenome=HelroG183398|UniProtKB=T1FJK5 T1FJK5 20209004 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185866|UniProtKB=T1FND5 T1FND5 20210332 PTHR11910:SF1 ATP SYNTHASE DELTA CHAIN ATP SYNTHASE SUBUNIT O, MITOCHONDRIAL monoatomic cation channel activity#GO:0005261;ligase activity#GO:0016874;inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;catalytic activity#GO:0003824;proton transmembrane transporter activity#GO:0015078;proton channel activity#GO:0015252;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;inorganic cation transmembrane transporter activity#GO:0022890;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 cellular aromatic compound metabolic process#GO:0006725;ribonucleoside triphosphate metabolic process#GO:0009199;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative metabolic process#GO:1901135;ATP biosynthetic process#GO:0006754;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;energy derivation by oxidation of organic compounds#GO:0015980;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;purine nucleoside triphosphate biosynthetic process#GO:0009145;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;heterocycle metabolic process#GO:0046483;purine ribonucleoside triphosphate metabolic process#GO:0009205;generation of precursor metabolites and energy#GO:0006091;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;ribonucleoside triphosphate biosynthetic process#GO:0009201;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;proton motive force-driven ATP synthesis#GO:0015986;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;oxidative phosphorylation#GO:0006119;aromatic compound biosynthetic process#GO:0019438;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;purine nucleoside triphosphate metabolic process#GO:0009144;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;proton-transporting two-sector ATPase complex, proton-transporting domain#GO:0033177;ATPase complex#GO:1904949;organelle inner membrane#GO:0019866;mitochondrial proton-transporting ATP synthase complex#GO:0005753;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;proton-transporting two-sector ATPase complex#GO:0016469;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)#GO:0000276;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;proton-transporting ATP synthase complex, coupling factor F(o)#GO:0045263;proton-transporting ATP synthase complex#GO:0045259;mitochondrial protein-containing complex#GO:0098798 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG194128|UniProtKB=T1FVQ2 T1FVQ2 20212898 PTHR18929:SF240 PROTEIN DISULFIDE ISOMERASE PROTEIN DISULFIDE-ISOMERASE isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;protein disulfide isomerase activity#GO:0003756 cellular response to stimulus#GO:0051716;macromolecule biosynthetic process#GO:0009059;response to endoplasmic reticulum stress#GO:0034976;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;response to stress#GO:0006950;protein folding#GO:0006457;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG181602|UniProtKB=T1FH58 T1FH58 20208157 PTHR48162:SF4 YALI0A06930P G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG78723|UniProtKB=T1G3F1 T1G3F1 20215599 PTHR12925:SF0 HIKESHI FAMILY MEMBER PROTEIN HIKESHI cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;protein import into nucleus#GO:0006606;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365;nuclear transport#GO:0051169;import into nucleus#GO:0051170 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG168552|UniProtKB=T1F0Q0 T1F0Q0 20202400 PTHR19282:SF560 TETRASPANIN BRCT DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG101461|UniProtKB=T1ED47 T1ED47 20194499 PTHR18914:SF9 ALPHA CATENIN CATENIN ALPHA cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;beta-catenin binding#GO:0008013;actin filament binding#GO:0051015 cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cell motility#GO:0048870;cellular process#GO:0009987;cell migration#GO:0016477 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;cell-cell junction#GO:0005911;anchoring junction#GO:0070161;plasma membrane protein complex#GO:0098797;cell junction#GO:0030054;adherens junction#GO:0005912;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;extrinsic component of membrane#GO:0019898 non-motor actin binding protein#PC00165 Alzheimer disease-presenilin pathway#P00004>alpha-catenin#P00133;Wnt signaling pathway#P00057>alpha-catenin#P01471 HELRO|EnsemblGenome=HelroG189016|UniProtKB=T1FQK4 T1FQK4 20211101 PTHR14270:SF0 NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9 NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;mRNA catabolic process#GO:0006402;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;organic substance catabolic process#GO:1901575;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;nuclear-transcribed mRNA catabolic process#GO:0000956;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 HELRO|EnsemblGenome=HelroG104950|UniProtKB=T1EDP3 T1EDP3 20194695 PTHR21646:SF14 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE FI05488P cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG62544|UniProtKB=T1FX21 T1FX21 20213369 PTHR12170:SF2 MACROPHAGE ERYTHROBLAST ATTACHER-RELATED E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA transferase activity#GO:0016740;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG175124|UniProtKB=T1F8W0 T1F8W0 20205259 PTHR13793:SF107 PHD FINGER PROTEINS BROMODOMAIN-CONTAINING PROTEIN HOMOLOG regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG110145|UniProtKB=T1EEZ8 T1EEZ8 20195150 PTHR15574:SF21 WD REPEAT DOMAIN-CONTAINING FAMILY DDB1- AND CUL4-ASSOCIATED FACTOR 8 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;Cul4-RING E3 ubiquitin ligase complex#GO:0080008;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191046|UniProtKB=T1FSJ3 T1FSJ3 20211790 PTHR24346:SF30 MAP/MICROTUBULE AFFINITY-REGULATING KINASE MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG178932|UniProtKB=T1FDX1 T1FDX1 20207020 PTHR10671:SF108 EPITHELIAL MEMBRANE PROTEIN-RELATED CLAUDIN FAMILY PROTEIN-RELATED cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG114074|UniProtKB=T1EFY8 T1EFY8 20195490 PTHR11893:SF36 INNEXIN INNEXIN-5 cell junction protein#PC00070;gap junction#PC00105 HELRO|EnsemblGenome=HelroG122071|UniProtKB=T1EGT8 T1EGT8 20195788 PTHR11767:SF102 INWARD RECTIFIER POTASSIUM CHANNEL INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of localization#GO:0032879;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;import across plasma membrane#GO:0098739;regulation of transport#GO:0051049;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;regulation of monoatomic ion transport#GO:0043269;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;potassium ion transport#GO:0006813;potassium ion import across plasma membrane#GO:1990573 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG182469|UniProtKB=T1FI89 T1FI89 20208538 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG71397|UniProtKB=T1G0K8 T1G0K8 20214606 PTHR24067:SF248 UBIQUITIN-CONJUGATING ENZYME E2 DORSAL INTERACTING PROTEIN 4 ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;SUMO transferase activity#GO:0019789;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein sumoylation#GO:0016925;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG155548|UniProtKB=T1ELI7 T1ELI7 20197437 PTHR11935:SF94 BETA LACTAMASE DOMAIN TENZING NORGAY, ISOFORM C hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;thiolester hydrolase activity#GO:0016790 HELRO|EnsemblGenome=HelroG185800|UniProtKB=T1FNA9 T1FNA9 20210306 PTHR13007:SF19 PRE-MRNA SPLICING FACTOR-RELATED PRE-MRNA-SPLICING FACTOR 18 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;mRNA splicing, via spliceosome#GO:0000398;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;U4/U6 x U5 tri-snRNP complex#GO:0046540;U2-type spliceosomal complex#GO:0005684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;U5 snRNP#GO:0005682;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;spliceosomal tri-snRNP complex#GO:0097526;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG66738|UniProtKB=T1FYQ2 T1FYQ2 20213950 PTHR20855:SF52 ADIPOR/PROGESTIN RECEPTOR-RELATED ADIPONECTIN RECEPTOR PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG81762|UniProtKB=T1G4I5 T1G4I5 20215983 PTHR10104:SF1 STATHMIN STATHMIN, ISOFORM D cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 regulation of microtubule-based process#GO:0032886;neurogenesis#GO:0022008;cell projection organization#GO:0030030;microtubule depolymerization#GO:0007019;developmental process#GO:0032502;microtubule cytoskeleton organization#GO:0000226;regulation of cellular component organization#GO:0051128;nervous system development#GO:0007399;microtubule polymerization or depolymerization#GO:0031109;plasma membrane bounded cell projection organization#GO:0120036;regulation of biological process#GO:0050789;system development#GO:0048731;cell differentiation#GO:0030154;regulation of cytoskeleton organization#GO:0051493;cellular component disassembly#GO:0022411;supramolecular fiber organization#GO:0097435;regulation of microtubule cytoskeleton organization#GO:0070507;neuron differentiation#GO:0030182;cytoskeleton organization#GO:0007010;cellular developmental process#GO:0048869;protein-containing complex disassembly#GO:0032984;regulation of organelle organization#GO:0033043;multicellular organism development#GO:0007275;cellular component organization#GO:0016043;protein depolymerization#GO:0051261;regulation of microtubule polymerization or depolymerization#GO:0031110;cellular process#GO:0009987;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;microtubule-based process#GO:0007017;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;protein-containing complex organization#GO:0043933;anatomical structure development#GO:0048856;biological regulation#GO:0065007;neuron development#GO:0048666;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 cytoplasm#GO:0005737;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;neuron projection#GO:0043005;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG192917|UniProtKB=T1FUF4 T1FUF4 20212450 PTHR31932:SF2 TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 1 TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 1 cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG109307|UniProtKB=T1EES2 T1EES2 20195074 PTHR16228:SF7 DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41 SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG139357|UniProtKB=T1EIY5 T1EIY5 20196535 PTHR13976:SF25 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED RNA-BINDING PROTEIN FUSILLI nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nitrogen compound metabolic process#GO:0051171;regulation of biosynthetic process#GO:0009889;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG195125|UniProtKB=T1FWS2 T1FWS2 20213267 PTHR24403:SF67 ZINC FINGER PROTEIN FI01116P-RELATED regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG92870|UniProtKB=T1G8M6 T1G8M6 20217423 PTHR11410:SF0 ATP SYNTHASE SUBUNIT A ATP SYNTHASE SUBUNIT A monoatomic cation channel activity#GO:0005261;ligase activity#GO:0016874;inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;catalytic activity#GO:0003824;proton transmembrane transporter activity#GO:0015078;proton channel activity#GO:0015252;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;inorganic cation transmembrane transporter activity#GO:0022890;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 cellular aromatic compound metabolic process#GO:0006725;ribonucleoside triphosphate metabolic process#GO:0009199;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative metabolic process#GO:1901135;ATP biosynthetic process#GO:0006754;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;purine nucleoside triphosphate biosynthetic process#GO:0009145;heterocycle metabolic process#GO:0046483;purine ribonucleoside triphosphate metabolic process#GO:0009205;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;ribonucleoside triphosphate biosynthetic process#GO:0009201;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;proton motive force-driven ATP synthesis#GO:0015986;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;purine nucleoside triphosphate metabolic process#GO:0009144;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;ATPase complex#GO:1904949;cellular anatomical entity#GO:0110165;membrane#GO:0016020;proton-transporting ATP synthase complex#GO:0045259;proton-transporting two-sector ATPase complex#GO:0016469 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 ATP synthesis#P02721>ATP synthetase F0#P02797 HELRO|EnsemblGenome=HelroG174298|UniProtKB=T1F7Y6 T1F7Y6 20204935 PTHR46670:SF2 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG92027|UniProtKB=T1G8B5 T1G8B5 20217312 PTHR10336:SF36 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4 hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phospholipase C activity#GO:0004629;phospholipase activity#GO:0004620;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;negative regulation of biological process#GO:0048519;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of sequestering of calcium ion#GO:0051282;release of sequestered calcium ion into cytosol#GO:0051209;regulation of localization#GO:0032879;cell communication#GO:0007154;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;calcium ion transport#GO:0006816;localization#GO:0051179;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;calcium ion transmembrane import into cytosol#GO:0097553;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;intracellular signal transduction#GO:0035556;monoatomic ion transport#GO:0006811;negative regulation of sequestering of calcium ion#GO:0051283;signaling#GO:0023052;monoatomic cation transmembrane transport#GO:0098655;negative regulation of cellular process#GO:0048523 phospholipase#PC00186 Metabotropic glutamate receptor group I pathway#P00041>PLC#P01053;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PLCbetagamma#P00874;Wnt signaling pathway#P00057>Phospholipase C#P01443;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>PLC#P01068;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PLC#P04581;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Phospholipase C-beta#P00744;EGF receptor signaling pathway#P00018>PLCgamma#P00556;Endothelin signaling pathway#P00019>PLCbeta#P00591;Alpha adrenergic receptor signaling pathway#P00002>PLC#P00073;Oxytocin receptor mediated signaling pathway#P04391>PLC beta#P04530;5HT2 type receptor mediated signaling pathway#P04374>PLC#P04412;Histamine H1 receptor mediated signaling pathway#P04385>PLC#P04484 HELRO|EnsemblGenome=HelroG86841|UniProtKB=T1G6I0 T1G6I0 20216677 PTHR10343:SF84 5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1 kinase modulator#PC00140 Gonadotropin-releasing hormone receptor pathway#P06664>AMPK#P06830;p53 pathway by glucose deprivation#P04397>AMPK#P04639 HELRO|EnsemblGenome=HelroG76281|UniProtKB=T1G2H7 T1G2H7 20215275 PTHR23293:SF9 FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE FAD SYNTHASE adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;organophosphate biosynthetic process#GO:0090407;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;nucleobase-containing compound biosynthetic process#GO:0034654;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086 transferase#PC00220;metabolite interconversion enzyme#PC00262 Flavin biosynthesis#P02741>FAD synthetase#P02936 HELRO|EnsemblGenome=HelroG185057|UniProtKB=T1FMC1 T1FMC1 20209970 PTHR11353:SF24 CHAPERONIN T-COMPLEX PROTEIN 1 SUBUNIT GAMMA protein binding#GO:0005515;unfolded protein binding#GO:0051082;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;chaperonin-containing T-complex#GO:0005832;protein folding chaperone complex#GO:0101031;intracellular anatomical structure#GO:0005622 chaperonin#PC00073 HELRO|EnsemblGenome=HelroG184060|UniProtKB=T1FKI3 T1FKI3 20209332 PTHR47027:SF20 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN HELRO|EnsemblGenome=HelroG71728|UniProtKB=T1G0Q5 T1G0Q5 20214653 PTHR19248:SF16 ATP-BINDING TRANSPORT PROTEIN-RELATED ATP-BINDING CASSETTE SUB-FAMILY E MEMBER 1 carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;cation binding#GO:0043169;organic cyclic compound binding#GO:0097159;iron ion binding#GO:0005506;nucleoside phosphate binding#GO:1901265;ribosome binding#GO:0043022;ribonucleoprotein complex binding#GO:0043021;heterocyclic compound binding#GO:1901363;protein-containing complex binding#GO:0044877;anion binding#GO:0043168;ion binding#GO:0043167;ATP binding#GO:0005524 protein-containing complex disassembly#GO:0032984;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;cellular component organization or biogenesis#GO:0071840;translational termination#GO:0006415;peptide biosynthetic process#GO:0043043;cellular component disassembly#GO:0022411;protein-containing complex organization#GO:0043933;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;translational initiation#GO:0006413;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 HELRO|EnsemblGenome=HelroG158795|UniProtKB=T1EN99 T1EN99 20198049 PTHR11927:SF9 GALACTOSIDE 2-L-FUCOSYLTRANSFERASE L-FUCOSYLTRANSFERASE transferase activity#GO:0016740;fucosyltransferase activity#GO:0008417;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein glycosylation#GO:0006486;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycosylation#GO:0070085;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG151577|UniProtKB=T1EKL2 T1EKL2 20197112 PTHR12141:SF5 ARFAPTIN-RELATED ARFAPTIN lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488 cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;trans-Golgi network membrane#GO:0032588;organelle subcompartment#GO:0031984;Golgi apparatus subcompartment#GO:0098791;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG179553|UniProtKB=T1FEV3 T1FEV3 20207352 PTHR11767:SF102 INWARD RECTIFIER POTASSIUM CHANNEL INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of localization#GO:0032879;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;import across plasma membrane#GO:0098739;regulation of transport#GO:0051049;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;regulation of monoatomic ion transport#GO:0043269;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;potassium ion transport#GO:0006813;potassium ion import across plasma membrane#GO:1990573 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG152908|UniProtKB=T1EKY0 T1EKY0 20197230 PTHR21146:SF0 MEF2B PROTEIN BLOC-1-RELATED COMPLEX SUBUNIT 8 p38 MAPK pathway#P05918>MEF#P06023 HELRO|EnsemblGenome=HelroG184669|UniProtKB=T1FLQ6 T1FLQ6 20209755 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184152|UniProtKB=T1FKP2 T1FKP2 20209391 PTHR12381:SF56 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U FAMILY MEMBER B30.2_SPRY DOMAIN-CONTAINING PROTEIN-RELATED nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;alternative mRNA splicing, via spliceosome#GO:0000380;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG182830|UniProtKB=T1FIT7 T1FIT7 20208736 PTHR11360:SF260 MONOCARBOXYLATE TRANSPORTER MFS DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;monocarboxylic acid transmembrane transporter activity#GO:0008028;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;monocarboxylic acid transport#GO:0015718;establishment of localization#GO:0051234;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942 transporter#PC00227 HELRO|EnsemblGenome=HelroG106175|UniProtKB=T1EE07 T1EE07 20194809 PTHR24055:SF158 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE P38A-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 TGF-beta signaling pathway#P00052>P38#P01275;Interferon-gamma signaling pathway#P00035>Serine kinase#P00955;EGF receptor signaling pathway#P00018>p38#P00562;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;p53 pathway feedback loops 2#P04398>p38 MAPK#P04648;Ras Pathway#P04393>p38#P04558;Parkinson disease#P00049>p38 MAPK#P01212;Oxidative stress response#P00046>p38#P01135;Parkinson disease#P00049>SAPK#P01219;FGF signaling pathway#P00021>p38#P00644 HELRO|EnsemblGenome=HelroG109814|UniProtKB=T1EEW5 T1EEW5 20195117 PTHR11932:SF169 CULLIN CULLIN 1 enzyme binding#GO:0019899;molecular adaptor activity#GO:0060090;protein binding#GO:0005515;ubiquitin protein ligase binding#GO:0031625;binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389;protein-macromolecule adaptor activity#GO:0030674 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Parkinson disease#P00049>Cul-1#P01239 HELRO|EnsemblGenome=HelroG185715|UniProtKB=T1FN68 T1FN68 20210266 PTHR23410:SF12 RIBOSOMAL PROTEIN L5-RELATED LARGE RIBOSOMAL SUBUNIT PROTEIN UL18 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;rRNA binding#GO:0019843;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;organelle assembly#GO:0070925;protein-RNA complex assembly#GO:0022618;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;ribosomal large subunit assembly#GO:0000027;ribonucleoprotein complex biogenesis#GO:0022613;protein-RNA complex organization#GO:0071826;ribosome biogenesis#GO:0042254;non-membrane-bounded organelle assembly#GO:0140694 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG183145|UniProtKB=T1FJ73 T1FJ73 20208872 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG64539|UniProtKB=T1FXW1 T1FXW1 20213659 PTHR10037:SF288 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM SODIUM CHANNEL PROTEIN PARA monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;sodium channel activity#GO:0005272;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;inorganic cation transmembrane transporter activity#GO:0022890 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;membrane depolarization#GO:0051899;transport#GO:0006810;regulation of membrane potential#GO:0042391;system process#GO:0003008;action potential#GO:0001508;nervous system process#GO:0050877;cell communication#GO:0007154;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;sodium ion transport#GO:0006814;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;multicellular organismal process#GO:0032501;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 membrane protein complex#GO:0098796;sodium channel complex#GO:0034706;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG72210|UniProtKB=T1G0X2 T1G0X2 20214720 PTHR18952:SF282 CARBONIC ANHYDRASE CARBONIC ANHYDRASE 1 carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG187749|UniProtKB=T1FPC6 T1FPC6 20210673 PTHR12227:SF0 GLYCERATE KINASE GLYCERATE KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;carbohydrate kinase#PC00065 HELRO|EnsemblGenome=HelroG95450|UniProtKB=T1G960 T1G960 20217607 PTHR18966:SF422 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED signaling receptor activity#GO:0038023;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;ligand-gated channel activity#GO:0022834 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019 HELRO|EnsemblGenome=HelroG174411|UniProtKB=T1F836 T1F836 20204985 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173394|UniProtKB=T1F6R9 T1F6R9 20204518 PTHR21037:SF3 39S RIBOSOMAL PROTEIN L14, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG66777|UniProtKB=T1FYQ8 T1FYQ8 20213956 PTHR11636:SF89 POU DOMAIN POU DOMAIN PROTEIN 2, ISOFORM B-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG111666|UniProtKB=T1EFD5 T1EFD5 20195287 PTHR11947:SF3 PYRUVATE DEHYDROGENASE KINASE [PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;regulation of metabolic process#GO:0019222;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG181851|UniProtKB=T1FHE3 T1FHE3 20208242 PTHR10340:SF34 SPHINGOMYELIN PHOSPHODIESTERASE SPHINGOMYELIN PHOSPHODIESTERASE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric diester hydrolase activity#GO:0008081;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 phosphodiesterase#PC00185;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG105042|UniProtKB=T1EDP9 T1EDP9 20194701 PTHR11722:SF0 60S RIBOSOMAL PROTEIN L13 LARGE RIBOSOMAL SUBUNIT PROTEIN EL13 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG163955|UniProtKB=T1EUN5 T1EUN5 20200285 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166710|UniProtKB=T1EYE6 T1EYE6 20201596 PTHR11616:SF320 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM-DEPENDENT NORADRENALINE TRANSPORTER metal ion transport#GO:0030001;transmembrane transport#GO:0055085;amino acid transport#GO:0006865;organic anion transport#GO:0015711;organic acid transport#GO:0015849;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;nitrogen compound transport#GO:0071705;carboxylic acid transport#GO:0046942;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;organic substance transport#GO:0071702;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 Adrenaline and noradrenaline biosynthesis#P00001>NET#P00064 HELRO|EnsemblGenome=HelroG177609|UniProtKB=T1FBY0 T1FBY0 20206329 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG108341|UniProtKB=T1EEI3 T1EEI3 20194985 PTHR11871:SF0 PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B PROTEIN PHOSPHATASE PP2A 55 KDA REGULATORY SUBUNIT phosphatase regulator activity#GO:0019208;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888;enzyme regulator activity#GO:0030234 protein serine/threonine phosphatase complex#GO:0008287;cytoplasm#GO:0005737;cytosol#GO:0005829;protein-containing complex#GO:0032991;cellular anatomical entity#GO:0110165;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 FGF signaling pathway#P00021>PP2A#P00629 HELRO|EnsemblGenome=HelroG156264|UniProtKB=T1ELT6 T1ELT6 20197536 PTHR12241:SF31 TUBULIN POLYGLUTAMYLASE POLYGLUTAMYLASE COMPLEX SUBUNIT TTLL1 cytoskeletal protein binding#GO:0008092;ligase activity#GO:0016874;protein binding#GO:0005515;tubulin binding#GO:0015631;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;microtubule cytoskeleton organization#GO:0000226;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;cellular component organization#GO:0016043;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;nitrogen compound metabolic process#GO:0006807;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;cilium#GO:0005929;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG194422|UniProtKB=T1FW14 T1FW14 20213010 PTHR24412:SF172 KELCH PROTEIN KELCH-LIKE PROTEIN 10 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185763|UniProtKB=T1FN94 T1FN94 20210292 PTHR23001:SF7 EUKARYOTIC TRANSLATION INITIATION FACTOR EUKARYOTIC TRANSLATION INITIATION FACTOR 5 nucleoside-triphosphatase regulator activity#GO:0060589;nucleic acid binding#GO:0003676;translation initiation factor binding#GO:0031369;translation regulator activity#GO:0045182;GTPase regulator activity#GO:0030695;binding#GO:0005488;organic cyclic compound binding#GO:0097159;molecular function regulator activity#GO:0098772;translation initiation factor activity#GO:0003743;protein binding#GO:0005515;translation regulator activity, nucleic acid binding#GO:0090079;enzyme regulator activity#GO:0030234;translation factor activity, RNA binding#GO:0008135 cellular component biogenesis#GO:0044085;peptide metabolic process#GO:0006518;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;translation#GO:0006412;protein-RNA complex assembly#GO:0022618;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cytoplasmic translation#GO:0002181;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;cytoplasmic translational initiation#GO:0002183;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;cellular component organization or biogenesis#GO:0071840;peptide biosynthetic process#GO:0043043;protein-containing complex organization#GO:0043933;ribonucleoprotein complex biogenesis#GO:0022613;translational initiation#GO:0006413;protein-RNA complex organization#GO:0071826 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG175648|UniProtKB=T1F9H0 T1F9H0 20205469 PTHR10269:SF12 GDNF RECEPTOR ALPHA GLIAL CELL LINE-DERIVED NEUROTROPHIC FAMILY RECEPTOR-LIKE, ISOFORM E signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 multicellular organismal process#GO:0032501;system development#GO:0048731;nervous system development#GO:0007399;anatomical structure development#GO:0048856;multicellular organism development#GO:0007275;developmental process#GO:0032502 receptor complex#GO:0043235;external side of plasma membrane#GO:0009897;cell surface#GO:0009986;protein-containing complex#GO:0032991;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;side of membrane#GO:0098552;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG180745|UniProtKB=T1FG83 T1FG83 20207832 PTHR12186:SF2 SIKE FAMILY MEMBER FGFR1 ONCOGENE PARTNER 2 HOMOLOG HELRO|EnsemblGenome=HelroG170169|UniProtKB=T1F2Q7 T1F2Q7 20203106 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG81350|UniProtKB=T1G4D5 T1G4D5 20215933 PTHR23506:SF23 GH10249P GH10249P secondary carrier transporter#PC00258;transporter#PC00227 Adrenaline and noradrenaline biosynthesis#P00001>VAT1#P00071;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>VAChT#P01078;5HT3 type receptor mediated signaling pathway#P04375>5HT vesicular transporter#P04424;5HT2 type receptor mediated signaling pathway#P04374>5HT vesicular transporter#P04418;Nicotinic acetylcholine receptor signaling pathway#P00044>VAChT#P01089;5HT4 type receptor mediated signaling pathway#P04376>5HT vesicular transporter#P04432;5HT1 type receptor mediated signaling pathway#P04373>5HT vesicular transporter#P04410 HELRO|EnsemblGenome=HelroG79183|UniProtKB=T1G3L2 T1G3L2 20215660 PTHR10290:SF3 DNA TOPOISOMERASE I DNA TOPOISOMERASE 1 DNA topoisomerase#PC00017 DNA replication#P00017>Top#P00530;DNA replication#P00017>DNA Topisomerase#P00536 HELRO|EnsemblGenome=HelroG193811|UniProtKB=T1FVD7 T1FVD7 20212783 PTHR46097:SF3 G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP ARF GTPASE-ACTIVATING PROTEIN GIT nucleoside-triphosphatase regulator activity#GO:0060589;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;binding#GO:0005488;molecular function regulator activity#GO:0098772;enzyme binding#GO:0019899;protein binding#GO:0005515;enzyme activator activity#GO:0008047;small GTPase binding#GO:0031267;enzyme regulator activity#GO:0030234 regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;regulation of signaling#GO:0023051;biological regulation#GO:0065007;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of intracellular signal transduction#GO:1902531;regulation of small GTPase mediated signal transduction#GO:0051056 HELRO|EnsemblGenome=HelroG96242|UniProtKB=T1G9B0 T1G9B0 20217657 PTHR11739:SF8 CITRATE SYNTHASE CITRATE SYNTHASE, MITOCHONDRIAL transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824 aerobic respiration#GO:0009060;cellular respiration#GO:0045333;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;cellular process#GO:0009987;carbohydrate metabolic process#GO:0005975;energy derivation by oxidation of organic compounds#GO:0015980;tricarboxylic acid cycle#GO:0006099;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 Pyruvate metabolism#P02772>Citrate Synthetase#P03141;TCA cycle#P00051>Citrate Synthase#P01267 HELRO|EnsemblGenome=HelroG165655|UniProtKB=T1EX48 T1EX48 20201148 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG90227|UniProtKB=T1G7M5 T1G7M5 20217072 PTHR22977:SF5 COX ASSEMBLY MITOCHONDRIAL PROTEIN COX ASSEMBLY MITOCHONDRIAL PROTEIN HOMOLOG cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG63593|UniProtKB=T1FXH9 T1FXH9 20213527 PTHR23147:SF189 SERINE/ARGININE RICH SPLICING FACTOR SERINE AND ARGININE-RICH-SPLICING FACTOR 3A nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;nuclear speck#GO:0016607;organelle#GO:0043226;nuclear body#GO:0016604;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG101759|UniProtKB=T1ED68 T1ED68 20194520 PTHR11932:SF168 CULLIN CULLIN-3 enzyme binding#GO:0019899;protein binding#GO:0005515;ubiquitin protein ligase binding#GO:0031625;binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185044|UniProtKB=T1FMB7 T1FMB7 20209966 PTHR44145:SF3 DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL chaperone#PC00072 HELRO|EnsemblGenome=HelroG159137|UniProtKB=T1ENN0 T1ENN0 20198180 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG156927|UniProtKB=T1EM34 T1EM34 20197634 PTHR11801:SF43 SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION SIGNAL TRANSDUCER AND TRANSCRIPTION ACTIVATOR sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 PDGF signaling pathway#P00047>STAT#P01173;EGF receptor signaling pathway#P00018>STAT#P00561 HELRO|EnsemblGenome=HelroG156368|UniProtKB=T1ELU5 T1ELU5 20197545 PTHR11915:SF422 SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN SPECTRIN ALPHA CHAIN, NON-ERYTHROCYTIC 1-RELATED cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;organelle organization#GO:0006996 cortical cytoskeleton#GO:0030863;cell junction#GO:0030054;cellular anatomical entity#GO:0110165;cell cortex#GO:0005938;cell periphery#GO:0071944;cortical actin cytoskeleton#GO:0030864;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cell projection#GO:0042995;plasma membrane#GO:0005886 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG121441|UniProtKB=T1EGS1 T1EGS1 20195771 PTHR22957:SF26 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN LD44506P nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;activation of GTPase activity#GO:0090630;biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG165422|UniProtKB=T1EWR6 T1EWR6 20201016 PTHR46289:SF19 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG194137|UniProtKB=T1FVQ8 T1FVQ8 20212904 PTHR14319:SF3 FIVE-SPAN TRANSMEMBRANE PROTEIN M83 TRANSMEMBRANE PROTEIN-LIKE PROTEIN cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG85360|UniProtKB=T1G5V7 T1G5V7 20216454 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG188735|UniProtKB=T1FQB3 T1FQB3 20211010 PTHR23280:SF13 4.1 G PROTEIN E3 UBIQUITIN-PROTEIN LIGASE MYLIP transferase activity#GO:0016740;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;actomyosin structure organization#GO:0031032;cellular component organization#GO:0016043;cellular process#GO:0009987;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;cytoskeleton organization#GO:0007010;organic substance catabolic process#GO:1901575;actin cytoskeleton organization#GO:0030036;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG169452|UniProtKB=T1F1Y5 T1F1Y5 20202835 PTHR18952:SF141 CARBONIC ANHYDRASE CARBONIC ANHYDRASE carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG191267|UniProtKB=T1FST5 T1FST5 20211882 PTHR43078:SF6 UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED UDP-GLUCURONIC ACID DECARBOXYLASE 1 nucleotide binding#GO:0000166;carboxy-lyase activity#GO:0016831;carbon-carbon lyase activity#GO:0016830;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;lyase activity#GO:0016829;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 decarboxylase#PC00089;lyase#PC00144 HELRO|EnsemblGenome=HelroG82751|UniProtKB=T1G4W1 T1G4W1 20216109 PTHR24353:SF111 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE SUBFAMILY NOT NAMED non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Endothelin signaling pathway#P00019>PKG#P00567 HELRO|EnsemblGenome=HelroG167280|UniProtKB=T1EZ79 T1EZ79 20201879 PTHR12673:SF241 FACIOGENITAL DYSPLASIA PROTEIN DH DOMAIN-CONTAINING PROTEIN nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cell projection organization#GO:0030030;organelle organization#GO:0006996;filopodium assembly#GO:0046847;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG173118|UniProtKB=T1F6E2 T1F6E2 20204391 PTHR33332:SF48 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173108|UniProtKB=T1F6D2 T1F6D2 20204381 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176179|UniProtKB=T1FA93 T1FA93 20205742 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173127|UniProtKB=T1F6E8 T1F6E8 20204397 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG114003|UniProtKB=T1EFY1 T1EFY1 20195483 PTHR10224:SF17 ES1 PROTEIN HOMOLOG, MITOCHONDRIAL DJ-1_PFPI DOMAIN-CONTAINING PROTEIN cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG163242|UniProtKB=T1ETT9 T1ETT9 20199989 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG105206|UniProtKB=T1EDR7 T1EDR7 20194719 PTHR10625:SF5 HISTONE DEACETYLASE HDAC1-RELATED HISTONE DEACETYLASE histone modifying activity#GO:0140993;histone deacetylase activity#GO:0004407;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;deacetylase activity#GO:0019213;catalytic activity, acting on a protein#GO:0140096 protein-DNA complex organization#GO:0071824;cellular component organization#GO:0016043;cellular process#GO:0009987;epigenetic regulation of gene expression#GO:0040029;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;protein-containing complex organization#GO:0043933;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;histone deacetylase complex#GO:0000118;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG194206|UniProtKB=T1FVT0 T1FVT0 20212926 PTHR23086:SF101 PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE LP03320P-RELATED transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301;lipid kinase activity#GO:0001727 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 kinase#PC00137 HELRO|EnsemblGenome=HelroG178131|UniProtKB=T1FCT1 T1FCT1 20206630 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG194223|UniProtKB=T1FVU0 T1FVU0 20212936 PTHR24064:SF577 SOLUTE CARRIER FAMILY 22 MEMBER GH09241P secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG98414|UniProtKB=T1G9M5 T1G9M5 20217771 PTHR24031:SF301 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX18 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of LSU-rRNA#GO:0000470;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG107993|UniProtKB=T1EEE6 T1EEE6 20194948 PTHR12270:SF25 GLYCOSYLTRANSFERASE-RELATED GLYCOSYLTRANSFERASE-LIKE PROTEIN LARGE glucuronosyltransferase activity#GO:0015020;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;UDP-glycosyltransferase activity#GO:0008194;pentosyltransferase activity#GO:0016763;xylosyltransferase activity#GO:0042285;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;protein O-linked mannosylation#GO:0035269;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein mannosylation#GO:0035268;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085;mannosylation#GO:0097502 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG171459|UniProtKB=T1F4B1 T1F4B1 20203660 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG107069|UniProtKB=T1EE71 T1EE71 20194873 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG133424|UniProtKB=T1EI09 T1EI09 20196209 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG77130|UniProtKB=T1G2T5 T1G2T5 20215383 PTHR11347:SF219 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE, ISOFORM I hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric diester hydrolase activity#GO:0008081;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;cAMP-mediated signaling#GO:0019933;signaling#GO:0023052;cyclic-nucleotide-mediated signaling#GO:0019935 phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG108569|UniProtKB=T1EEK4 T1EEK4 20195006 PTHR13218:SF8 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;RNA metabolic process#GO:0016070;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;RNA polymerase II preinitiation complex assembly#GO:0051123;transcription initiation at RNA polymerase II promoter#GO:0006367;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;DNA-directed RNA polymerase complex#GO:0000428;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nucleoplasm#GO:0005654;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;transcription factor TFIID complex#GO:0005669;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;transcription regulator complex#GO:0005667;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 general transcription factor#PC00259 General transcription regulation#P00023>TBP-associated factors#P00658;Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385 HELRO|EnsemblGenome=HelroG171521|UniProtKB=T1F4D3 T1F4D3 20203682 PTHR11782:SF83 ADENOSINE/GUANOSINE DIPHOSPHATASE GUANOSINE-DIPHOSPHATASE pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;nucleoside diphosphate phosphatase activity#GO:0017110;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;nucleoside phosphate catabolic process#GO:1901292;heterocycle catabolic process#GO:0046700;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleoside diphosphate catabolic process#GO:0009134;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate catabolic process#GO:0046434;phosphate-containing compound metabolic process#GO:0006796;cellular nitrogen compound catabolic process#GO:0044270;aromatic compound catabolic process#GO:0019439;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;organic cyclic compound catabolic process#GO:1901361;catabolic process#GO:0009056;nucleoside diphosphate metabolic process#GO:0009132;organophosphate metabolic process#GO:0019637;organic substance catabolic process#GO:1901575;nucleobase-containing compound catabolic process#GO:0034655;small molecule metabolic process#GO:0044281;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248 cellular anatomical entity#GO:0110165;membrane#GO:0016020 metabolite interconversion enzyme#PC00262;phosphatase#PC00181;nucleotide phosphatase#PC00173 HELRO|EnsemblGenome=HelroG183587|UniProtKB=T1FJV9 T1FJV9 20209108 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG111011|UniProtKB=T1EF70 T1EF70 20195222 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-LIKE 1 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;localization#GO:0051179;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 membrane protein complex#GO:0098796;synapse#GO:0045202;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron projection#GO:0043005;transmembrane transporter complex#GO:1902495;cell projection#GO:0042995;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HELRO|EnsemblGenome=HelroG131728|UniProtKB=T1EHW5 T1EHW5 20196165 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-LIKE 1 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;localization#GO:0051179;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 membrane protein complex#GO:0098796;synapse#GO:0045202;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron projection#GO:0043005;transmembrane transporter complex#GO:1902495;cell projection#GO:0042995;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HELRO|EnsemblGenome=HelroG75686|UniProtKB=T1G290 T1G290 20215188 PTHR22974:SF23 MIXED LINEAGE PROTEIN KINASE TOUSLED-LIKE KINASE, ISOFORM G transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;cell cycle process#GO:0022402;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;chromosome segregation#GO:0007059;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell cycle#GO:0007049;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG189937|UniProtKB=T1FRI1 T1FRI1 20211428 PTHR45080:SF8 CONTACTIN 5 IG-LIKE DOMAIN-CONTAINING PROTEIN cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG185431|UniProtKB=T1FMT4 T1FMT4 20210133 PTHR24347:SF454 SERINE/THREONINE-PROTEIN KINASE PHOSPHORYLASE KINASE non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716 HELRO|EnsemblGenome=HelroG190435|UniProtKB=T1FRZ6 T1FRZ6 20211593 PTHR13021:SF8 PRE-MRNA-SPLICING FACTOR ISY1 PRE-MRNA-SPLICING FACTOR ISY1 HOMOLOG cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;mRNA splicing, via spliceosome#GO:0000398;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;mRNA splice site recognition#GO:0006376;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375;spliceosomal complex assembly#GO:0000245 ribonucleoprotein complex#GO:1990904;catalytic step 2 spliceosome#GO:0071013;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;post-mRNA release spliceosomal complex#GO:0071014;spliceosomal complex#GO:0005681;Prp19 complex#GO:0000974;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG176287|UniProtKB=T1FAD3 T1FAD3 20205782 PTHR14063:SF1 PROTEIN LIN-7 HOMOLOG PDZ DOMAIN-CONTAINING PROTEIN 11 establishment or maintenance of cell polarity#GO:0007163;cellular localization#GO:0051641;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;macromolecule localization#GO:0033036;transport#GO:0006810;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;secretion#GO:0046903;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;signal release#GO:0023061;establishment or maintenance of apical/basal cell polarity#GO:0035088;cell-cell signaling#GO:0007267;signaling#GO:0023052;secretion by cell#GO:0032940;neurotransmitter secretion#GO:0007269;localization within membrane#GO:0051668;protein localization to membrane#GO:0072657;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;protein localization#GO:0008104;protein localization to cell periphery#GO:1990778;localization#GO:0051179;cellular macromolecule localization#GO:0070727;signal release from synapse#GO:0099643;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;establishment or maintenance of bipolar cell polarity#GO:0061245;export from cell#GO:0140352 basal plasma membrane#GO:0009925;synapse#GO:0045202;anchoring junction#GO:0070161;cell-cell junction#GO:0005911;basolateral plasma membrane#GO:0016323;cell junction#GO:0030054;plasma membrane region#GO:0098590;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;basal part of cell#GO:0045178;membrane#GO:0016020;plasma membrane#GO:0005886 cell junction protein#PC00070 HELRO|EnsemblGenome=HelroG191434|UniProtKB=T1FSZ3 T1FSZ3 20211940 PTHR47238:SF2 MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5 DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE HEMIPTEROUS non-receptor serine/threonine protein kinase#PC00167 FGF signaling pathway#P00021>MKK4,7#P00637;EGF receptor signaling pathway#P00018>MKK4,7#P00555 HELRO|EnsemblGenome=HelroG172966|UniProtKB=T1F682 T1F682 20204331 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189221|UniProtKB=T1FQT5 T1FQT5 20211182 PTHR46077:SF5 E3 UBIQUITIN-PROTEIN LIGASE TOPORS RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein monoubiquitination#GO:0006513;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG76483|UniProtKB=T1G2K4 T1G2K4 20215302 PTHR10514:SF27 ANGIOTENSIN-CONVERTING ENZYME ANGIOTENSIN-CONVERTING ENZYME metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG181020|UniProtKB=T1FGJ4 T1FGJ4 20207943 PTHR13437:SF7 NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1 CXXC-TYPE DOMAIN-CONTAINING PROTEIN signal sequence binding#GO:0005048;structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056;binding#GO:0005488;peptide binding#GO:0042277;amide binding#GO:0033218 envelope#GO:0031975;nuclear pore#GO:0005643;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG125192|UniProtKB=T1EH48 T1EH48 20195898 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED single-stranded RNA binding#GO:0003727;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;poly(A) binding#GO:0008143;binding#GO:0005488;organic cyclic compound binding#GO:0097159 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG174006|UniProtKB=T1F7H0 T1F7H0 20204769 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190408|UniProtKB=T1FRY9 T1FRY9 20211586 PTHR19423:SF1 SH3 DOMAIN-BINDING PROTEIN 5 SH3 DOMAIN-BINDING PROTEIN 5 enzyme inhibitor activity#GO:0004857;protein kinase regulator activity#GO:0019887;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase inhibitor activity#GO:0004860 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG181303|UniProtKB=T1FGV5 T1FGV5 20208054 PTHR47018:SF4 CXC DOMAIN-CONTAINING PROTEIN-RELATED SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG181426|UniProtKB=T1FH00 T1FH00 20208099 PTHR13526:SF8 TRANSCRIPTION FACTOR SPT20 HOMOLOG TRANSCRIPTION FACTOR SPT20 HOMOLOG molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 SAGA-type complex#GO:0070461;peptidase complex#GO:1905368;histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;chromosome#GO:0005694;SAGA complex#GO:0000124 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG79446|UniProtKB=T1G3N9 T1G3N9 20215687 PTHR10926:SF0 CELL CYCLE CONTROL PROTEIN 50 CDC50, ISOFORM A cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG186292|UniProtKB=T1FNX7 T1FNX7 20210524 PTHR12658:SF0 BETA-TUBULIN COFACTOR D TUBULIN-SPECIFIC CHAPERONE D nucleoside-triphosphatase regulator activity#GO:0060589;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;binding#GO:0005488;molecular function regulator activity#GO:0098772;protein binding#GO:0005515;enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;microtubule cytoskeleton organization#GO:0000226;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;protein folding#GO:0006457;nitrogen compound metabolic process#GO:0006807;cytoskeleton organization#GO:0007010;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 chaperone#PC00072 HELRO|EnsemblGenome=HelroG179028|UniProtKB=T1FE26 T1FE26 20207075 PTHR11339:SF402 EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED VWFD DOMAIN-CONTAINING PROTEIN extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG102643|UniProtKB=T1EDA8 T1EDA8 20194560 PTHR12466:SF8 CDC73 DOMAIN PROTEIN PARAFIBROMIN basal RNA polymerase II transcription machinery binding#GO:0001099;RNA polymerase binding#GO:0070063;binding#GO:0005488;RNA polymerase core enzyme binding#GO:0043175;RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515;enzyme binding#GO:0019899;basal transcription machinery binding#GO:0001098 regulation of transcription elongation by RNA polymerase II#GO:0034243;cellular component biogenesis#GO:0044085;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;positive regulation of transcription by RNA polymerase II#GO:0045944;gene expression#GO:0010467;positive regulation of DNA-templated transcription, elongation#GO:0032786;regulation of RNA biosynthetic process#GO:2001141;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;nitrogen compound metabolic process#GO:0006807;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;cellular component assembly#GO:0022607;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;cellular component organization or biogenesis#GO:0071840;regulation of cellular process#GO:0050794;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;positive regulation of nitrogen compound metabolic process#GO:0051173;cellular aromatic compound metabolic process#GO:0006725;positive regulation of transcription elongation by RNA polymerase II#GO:0032968;positive regulation of RNA biosynthetic process#GO:1902680;RNA metabolic process#GO:0016070;regulation of transcription by RNA polymerase II#GO:0006357;protein-containing complex assembly#GO:0065003;RNA processing#GO:0006396;biosynthetic process#GO:0009058;mRNA 3'-end processing#GO:0031124;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;organic cyclic compound metabolic process#GO:1901360;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;metabolic process#GO:0008152;regulation of DNA-templated transcription elongation#GO:0032784;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA 3'-end processing#GO:0031123;regulation of DNA-templated transcription#GO:0006355;cellular biosynthetic process#GO:0044249;positive regulation of cellular biosynthetic process#GO:0031328;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;nucleic acid metabolic process#GO:0090304;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;protein-containing complex organization#GO:0043933;ribonucleoprotein complex biogenesis#GO:0022613;biological regulation#GO:0065007;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;positive regulation of RNA metabolic process#GO:0051254 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;DNA-directed RNA polymerase complex#GO:0000428;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nucleoplasm#GO:0005654;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;transcription elongation factor complex#GO:0008023;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;Cdc73/Paf1 complex#GO:0016593;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG169784|UniProtKB=T1F2B5 T1F2B5 20202965 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG106279|UniProtKB=T1EE13 T1EE13 20194815 PTHR11767:SF102 INWARD RECTIFIER POTASSIUM CHANNEL INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of localization#GO:0032879;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;import across plasma membrane#GO:0098739;regulation of transport#GO:0051049;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;regulation of monoatomic ion transport#GO:0043269;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;potassium ion transport#GO:0006813;potassium ion import across plasma membrane#GO:1990573 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG184367|UniProtKB=T1FL24 T1FL24 20209523 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184906|UniProtKB=T1FM57 T1FM57 20209906 PTHR13247:SF0 TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11 MITOCHONDRIAL FISSION 1 PROTEIN cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;autophagy of mitochondrion#GO:0000422;cellular process#GO:0009987;organelle disassembly#GO:1903008;process utilizing autophagic mechanism#GO:0061919;cellular component organization or biogenesis#GO:0071840;cellular component disassembly#GO:0022411;organelle organization#GO:0006996;organelle fission#GO:0048285;catabolic process#GO:0009056;mitochondrion organization#GO:0007005;peroxisome organization#GO:0007031;autophagy#GO:0006914;mitochondrial fission#GO:0000266;metabolic process#GO:0008152;cellular catabolic process#GO:0044248 envelope#GO:0031975;bounding membrane of organelle#GO:0098588;peroxisomal membrane#GO:0005778;mitochondrial membrane#GO:0031966;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;microbody#GO:0042579;membrane-bounded organelle#GO:0043227;peroxisome#GO:0005777;outer membrane#GO:0019867 HELRO|EnsemblGenome=HelroG64615|UniProtKB=T1FXX0 T1FXX0 20213668 PTHR23138:SF87 RAN BINDING PROTEIN E3 SUMO-PROTEIN LIGASE RANBP2 nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 envelope#GO:0031975;cytoplasm#GO:0005737;nuclear pore#GO:0005643;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185150|UniProtKB=T1FMG2 T1FMG2 20210011 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG64184|UniProtKB=T1FXQ9 T1FXQ9 20213607 PTHR24033:SF225 EGF-LIKE DOMAIN-CONTAINING PROTEIN EGF-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163020|UniProtKB=T1ETK8 T1ETK8 20199908 PTHR13723:SF306 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG71267|UniProtKB=T1G0I6 T1G0I6 20214584 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG155894|UniProtKB=T1ELN8 T1ELN8 20197488 PTHR11831:SF5 30S 40S RIBOSOMAL PROTEIN 40S RIBOSOMAL PROTEIN S9 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159;rRNA binding#GO:0019843 cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;ribosome biogenesis#GO:0042254;cellular process#GO:0009987;ribosomal small subunit biogenesis#GO:0042274;ribonucleoprotein complex biogenesis#GO:0022613 intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;small ribosomal subunit#GO:0015935;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG185228|UniProtKB=T1FMJ3 T1FMJ3 20210042 PTHR11705:SF91 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B FI01817P-RELATED metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metallocarboxypeptidase activity#GO:0004181;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;carboxypeptidase activity#GO:0004180 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG175392|UniProtKB=T1F984 T1F984 20205383 PTHR34524:SF15 CALCYPHOSIN EF-HAND DOMAIN-CONTAINING PROTEIN calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG173421|UniProtKB=T1F6T0 T1F6T0 20204529 PTHR48031:SF2 SRA STEM-LOOP-INTERACTING RNA-BINDING PROTEIN, MITOCHONDRIAL RNA-BINDING PROTEIN 4 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 HELRO|EnsemblGenome=HelroG64438|UniProtKB=T1FXU9 T1FXU9 20213647 PTHR11136:SF5 FOLYLPOLYGLUTAMATE SYNTHASE-RELATED FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;folic acid-containing compound metabolic process#GO:0006760;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;cellular modified amino acid metabolic process#GO:0006575;aromatic compound biosynthetic process#GO:0019438;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 Formyltetrahydrofolate biosynthesis#P02743>Dihydrofolate synthase#P02958;Tetrahydrofolate biosynthesis#P02742>Dihydrofolate synthase#P02943 HELRO|EnsemblGenome=HelroG191117|UniProtKB=T1FSL8 T1FSL8 20211815 PTHR24214:SF38 PDZ AND LIM DOMAIN PROTEIN ZASP PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG193143|UniProtKB=T1FUN6 T1FUN6 20212532 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;chloride transmembrane transporter activity#GO:0015108;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;inorganic anion transmembrane transport#GO:0098661;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic anion transport#GO:0006820;chloride transport#GO:0006821;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;inorganic anion transport#GO:0015698 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG182861|UniProtKB=T1FIV9 T1FIV9 20208758 PTHR21437:SF1 WIDE AWAKE WIDE AWAKE HELRO|EnsemblGenome=HelroG168799|UniProtKB=T1F0Z5 T1F0Z5 20202495 PTHR10027:SF33 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic ion-gated channel activity#GO:0022839;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium-activated cation channel activity#GO:0005227;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG70687|UniProtKB=T1G0A7 T1G0A7 20214505 PTHR45894:SF1 RNA-BINDING PROTEIN 8A RNA-BINDING PROTEIN 8A nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185270|UniProtKB=T1FML1 T1FML1 20210060 PTHR24068:SF141 UBIQUITIN-CONJUGATING ENZYME E2 AT16033P-RELATED ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;postreplication repair#GO:0006301;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;post-translational protein modification#GO:0043687;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;response to stress#GO:0006950;nitrogen compound metabolic process#GO:0006807;protein polyubiquitination#GO:0000209;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;protein K63-linked ubiquitination#GO:0070534;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Toll receptor signaling pathway#P00054>Ubc13#P01381;Ubiquitin proteasome pathway#P00060>E2#P01491 HELRO|EnsemblGenome=HelroG171104|UniProtKB=T1F3T3 T1F3T3 20203482 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161829|UniProtKB=T1ERY4 T1ERY4 20199334 PTHR11595:SF21 EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER ELONGATION FACTOR 1-BETA nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;translational elongation#GO:0006414;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 translation elongation factor#PC00222;translational protein#PC00263 HELRO|EnsemblGenome=HelroG184069|UniProtKB=T1FKI8 T1FKI8 20209337 PTHR24356:SF1 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE GREATWALL non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG192060|UniProtKB=T1FTJ9 T1FTJ9 20212146 PTHR12582:SF47 NETRIN RECEPTOR UNC5 NETRIN RECEPTOR UNC-5 transmembrane signal receptor#PC00197 Axon guidance mediated by netrin#P00009>UNC-5#P00356 HELRO|EnsemblGenome=HelroG84823|UniProtKB=T1G5P2 T1G5P2 20216389 PTHR11011:SF116 MALE STERILITY PROTEIN 2-RELATED FATTY ACYL-COA REDUCTASE CG5065-RELATED oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;lipid metabolic process#GO:0006629;heterocycle metabolic process#GO:0046483;carbohydrate derivative metabolic process#GO:1901135;sulfur compound metabolic process#GO:0006790;acyl-CoA metabolic process#GO:0006637;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;amide metabolic process#GO:0043603;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;nucleobase-containing small molecule metabolic process#GO:0055086 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;microbody#GO:0042579;membrane-bounded organelle#GO:0043227;peroxisome#GO:0005777;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG74970|UniProtKB=T1G1Y8 T1G1Y8 20215086 PTHR45694:SF5 GLUTAREDOXIN 2 GLUTAREDOXIN 2 disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;response to stress#GO:0006950;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;cellular response to oxidative stress#GO:0034599;response to oxidative stress#GO:0006979;cellular response to stress#GO:0033554;cellular process#GO:0009987 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG163539|UniProtKB=T1EU62 T1EU62 20200112 PTHR46077:SF5 E3 UBIQUITIN-PROTEIN LIGASE TOPORS RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein monoubiquitination#GO:0006513;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG180928|UniProtKB=T1FGF6 T1FGF6 20207905 PTHR19303:SF71 TRANSPOSON ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG82746|UniProtKB=T1G4W0 T1G4W0 20216108 PTHR24104:SF57 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED BEE-MILK PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG71383|UniProtKB=T1G0K6 T1G0K6 20214604 PTHR21320:SF3 CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED chaperone#PC00072 HELRO|EnsemblGenome=HelroG72124|UniProtKB=T1G0W0 T1G0W0 20214708 PTHR15382:SF8 CTG4A-RELATED CANOPY B HELRO|EnsemblGenome=HelroG181785|UniProtKB=T1FHB6 T1FHB6 20208215 PTHR10288:SF338 KH DOMAIN CONTAINING RNA BINDING PROTEIN IGF-II MRNA-BINDING PROTEIN, ISOFORM L nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159;mRNA 3'-UTR binding#GO:0003730 developmental process#GO:0032502;multicellular organism development#GO:0007275;nervous system development#GO:0007399;regulation of biological process#GO:0050789;system development#GO:0048731;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG80908|UniProtKB=T1G470 T1G470 20215868 PTHR14952:SF9 ROPPORIN-1-LIKE PROTEIN EF-HAND DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG63354|UniProtKB=T1FXE7 T1FXE7 20213495 PTHR10027:SF33 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic ion-gated channel activity#GO:0022839;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium-activated cation channel activity#GO:0005227;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG91406|UniProtKB=T1G833 T1G833 20217230 PTHR46107:SF3 DUMPY: SHORTER THAN WILD-TYPE THIOREDOXIN DOMAIN-CONTAINING PROTEIN disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG184333|UniProtKB=T1FL07 T1FL07 20209506 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177709|UniProtKB=T1FC42 T1FC42 20206391 PTHR11733:SF133 ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED PHOSPHATE-REGULATING NEUTRAL ENDOPEPTIDASE PHEX hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Endothelin signaling pathway#P00019>ECE1-3#P00585 HELRO|EnsemblGenome=HelroG188565|UniProtKB=T1FQ47 T1FQ47 20210944 PTHR12461:SF106 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED BIFUNCTIONAL PEPTIDASE AND ARGINYL-HYDROXYLASE JMJD5 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG188209|UniProtKB=T1FPS1 T1FPS1 20210818 PTHR24418:SF372 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE SHARK protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG159141|UniProtKB=T1ENN3 T1ENN3 20198183 PTHR33337:SF44 GFA DOMAIN-CONTAINING PROTEIN DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G09754) HELRO|EnsemblGenome=HelroG172124|UniProtKB=T1F520 T1F520 20203919 PTHR44144:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 9 DNAJ HOMOLOG SUBFAMILY C MEMBER 9 protein binding#GO:0005515;heat shock protein binding#GO:0031072;binding#GO:0005488 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG188740|UniProtKB=T1FQB5 T1FQB5 20211012 PTHR12650:SF15 40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI RIBOSOMAL PROTEIN S30, ISOFORM A cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;small ribosomal subunit#GO:0015935;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG160184|UniProtKB=T1EPY0 T1EPY0 20198630 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184139|UniProtKB=T1FKN5 T1FKN5 20209384 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG122641|UniProtKB=T1EGV4 T1EGV4 20195804 PTHR47023:SF1 SEX PEPTIDE RECEPTOR SEX PEPTIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG166761|UniProtKB=T1EYH5 T1EYH5 20201625 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG116784|UniProtKB=T1EGH7 T1EGH7 20195679 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;chloride transmembrane transporter activity#GO:0015108;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;inorganic anion transmembrane transport#GO:0098661;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic anion transport#GO:0006820;chloride transport#GO:0006821;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;inorganic anion transport#GO:0015698 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG166296|UniProtKB=T1EY00 T1EY00 20201450 PTHR13248:SF4 TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2 ELONGIN B RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG169285|UniProtKB=T1F1Q3 T1F1Q3 20202753 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG163149|UniProtKB=T1ETQ5 T1ETQ5 20199955 PTHR19134:SF536 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE DOMAIN-CONTAINING PROTEIN hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG170675|UniProtKB=T1F3B2 T1F3B2 20203311 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG159950|UniProtKB=T1EPL3 T1EPL3 20198513 PTHR31362:SF0 GLYCOSYLTRANSFERASE STELLO1-RELATED EXOSTOSIN DOMAIN-CONTAINING PROTEIN-RELATED glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG64451|UniProtKB=T1FXV2 T1FXV2 20213650 PTHR15217:SF0 WILMS' TUMOR 1-ASSOCIATING PROTEIN PRE-MRNA-SPLICING REGULATOR WTAP cellular aromatic compound metabolic process#GO:0006725;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;regulation of nitrogen compound metabolic process#GO:0051171;RNA modification#GO:0009451;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;regulation of mRNA processing#GO:0050684;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;mRNA modification#GO:0016556;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;primary metabolic process#GO:0044238;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;nucleic acid metabolic process#GO:0090304;macromolecule methylation#GO:0043414;methylation#GO:0032259;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;RNA methylation#GO:0001510;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of metabolic process#GO:0019222;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;regulation of cellular metabolic process#GO:0031323;regulation of mRNA metabolic process#GO:1903311 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG188868|UniProtKB=T1FQF2 T1FQF2 20211049 PTHR31543:SF0 DYNEIN REGULATORY COMPLEX SUBUNIT 4 DYNEIN REGULATORY COMPLEX SUBUNIT 4 supramolecular complex#GO:0099080;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;cellular anatomical entity#GO:0110165;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;endomembrane system#GO:0012505;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;microtubule#GO:0005874 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG114110|UniProtKB=T1EFZ0 T1EFZ0 20195492 PTHR11559:SF370 CARBOXYLESTERASE ACETYLCHOLINESTERASE esterase#PC00097;hydrolase#PC00121 Nicotinic acetylcholine receptor signaling pathway#P00044>AChE#P01093;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>AChE#P01067;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>AChE#P01080 HELRO|EnsemblGenome=HelroG163440|UniProtKB=T1EU19 T1EU19 20200069 PTHR46077:SF5 E3 UBIQUITIN-PROTEIN LIGASE TOPORS RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein monoubiquitination#GO:0006513;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG77420|UniProtKB=T1G2X3 T1G2X3 20215421 PTHR10024:SF234 SYNAPTOTAGMIN SYNAPTOTAGMIN-15-RELATED cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;phosphatidylserine binding#GO:0001786;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;protein binding#GO:0005515;clathrin binding#GO:0030276;lipid binding#GO:0008289;ion binding#GO:0043167;phospholipid binding#GO:0005543;SNARE binding#GO:0000149 localization#GO:0051179;regulated exocytosis#GO:0045055;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;calcium-ion regulated exocytosis#GO:0017156;export from cell#GO:0140352;secretion by cell#GO:0032940 intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;secretory vesicle#GO:0099503;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG165840|UniProtKB=T1EXC7 T1EXC7 20201227 PTHR24351:SF228 RIBOSOMAL PROTEIN S6 KINASE PROTEIN KINASE C transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG160116|UniProtKB=T1EPT8 T1EPT8 20198588 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN SI:DKEY-17M8.2 HELRO|EnsemblGenome=HelroG183091|UniProtKB=T1FJ53 T1FJ53 20208852 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185413|UniProtKB=T1FMS4 T1FMS4 20210123 PTHR45758:SF4 MITOFERRIN-1-RELATED MITOFERRIN-1 inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;inorganic cation transmembrane transporter activity#GO:0022890;metal ion transmembrane transporter activity#GO:0046873 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;iron ion transmembrane transport#GO:0034755;mitochondrial transport#GO:0006839;localization#GO:0051179;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transport#GO:0006812;iron ion transport#GO:0006826;transition metal ion transport#GO:0000041;monoatomic ion transport#GO:0006811;mitochondrial transmembrane transport#GO:1990542;monoatomic cation transmembrane transport#GO:0098655 envelope#GO:0031975;cytoplasm#GO:0005737;mitochondrial membrane#GO:0031966;intracellular membrane-bounded organelle#GO:0043231;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG119046|UniProtKB=T1EGM3 T1EGM3 20195723 PTHR10027:SF33 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic ion-gated channel activity#GO:0022839;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium-activated cation channel activity#GO:0005227;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG164072|UniProtKB=T1EUV7 T1EUV7 20200357 PTHR46880:SF5 RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG99990|UniProtKB=T1G9W0 T1G9W0 20217856 PTHR43778:SF2 PYRUVATE CARBOXYLASE PYRUVATE CARBOXYLASE, MITOCHONDRIAL ligase activity#GO:0016874;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;monosaccharide metabolic process#GO:0005996;carbohydrate biosynthetic process#GO:0016051;cellular metabolic process#GO:0044237;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;glucose metabolic process#GO:0006006;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;hexose biosynthetic process#GO:0019319;small molecule biosynthetic process#GO:0044283;hexose metabolic process#GO:0019318;carbohydrate metabolic process#GO:0005975;carboxylic acid metabolic process#GO:0019752;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 Pyruvate metabolism#P02772>Pyruvate Carboxylase#P03140 HELRO|EnsemblGenome=HelroG64880|UniProtKB=T1FY06 T1FY06 20213704 PTHR16290:SF0 TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1 DECAPPING PROTEIN 1, ISOFORM A RNA binding#GO:0003723;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 negative regulation of gene expression#GO:0010629;regulation of catabolic process#GO:0009894;heterocycle catabolic process#GO:0046700;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;nucleobase-containing compound metabolic process#GO:0006139;RNA destabilization#GO:0050779;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;regulation of biological quality#GO:0065008;nitrogen compound metabolic process#GO:0006807;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;positive regulation of mRNA catabolic process#GO:0061014;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of catabolic process#GO:0009896;mRNA destabilization#GO:0061157;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323;positive regulation of nitrogen compound metabolic process#GO:0051173;cellular aromatic compound metabolic process#GO:0006725;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;RNA metabolic process#GO:0016070;positive regulation of cellular catabolic process#GO:0031331;cellular nitrogen compound catabolic process#GO:0044270;RNA decapping#GO:0110154;organic cyclic compound metabolic process#GO:1901360;positive regulation of metabolic process#GO:0009893;mRNA catabolic process#GO:0006402;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;positive regulation of mRNA metabolic process#GO:1903313;heterocycle metabolic process#GO:0046483;negative regulation of biosynthetic process#GO:0009890;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of cellular catabolic process#GO:0031329;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;positive regulation of RNA metabolic process#GO:0051254 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;P-body#GO:0000932;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic ribonucleoprotein granule#GO:0036464 RNA processing factor#PC00147;mRNA capping factor#PC00145 TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282 HELRO|EnsemblGenome=HelroG176399|UniProtKB=T1FAH3 T1FAH3 20205822 PTHR44314:SF1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 70 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 70 cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;cilium movement#GO:0003341;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;plasma membrane bounded cell projection assembly#GO:0120031 motile cilium#GO:0031514;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cilium#GO:0005929;organelle#GO:0043226;vesicle#GO:0031982 structural protein#PC00211 HELRO|EnsemblGenome=HelroG182583|UniProtKB=T1FIE6 T1FIE6 20208595 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG170589|UniProtKB=T1F377 T1F377 20203276 PTHR46169:SF29 DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG192009|UniProtKB=T1FTI2 T1FTI2 20212129 PTHR23291:SF47 BAX INHIBITOR-RELATED TRANSMEMBRANE BAX INHIBITOR MOTIF CONTAINING 7 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG71411|UniProtKB=T1G0L1 T1G0L1 20214609 PTHR24346:SF82 MAP/MICROTUBULE AFFINITY-REGULATING KINASE KP78A-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG180060|UniProtKB=T1FFF2 T1FFF2 20207551 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG88518|UniProtKB=T1G735 T1G735 20216882 PTHR22950:SF244 AMINO ACID TRANSPORTER NEUTRAL AMINO ACID TRANSPORTER 9 L-amino acid transmembrane transporter activity#GO:0015179;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171;organic anion transmembrane transporter activity#GO:0008514;organic acid transmembrane transporter activity#GO:0005342;transporter activity#GO:0005215 localization#GO:0051179;organic substance transport#GO:0071702;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;organic anion transport#GO:0015711;amino acid transport#GO:0006865;organic acid transport#GO:0015849;transport#GO:0006810;nitrogen compound transport#GO:0071705;organic acid transmembrane transport#GO:1903825;carboxylic acid transport#GO:0046942;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039 bounding membrane of organelle#GO:0098588;lytic vacuole membrane#GO:0098852;intracellular membrane-bounded organelle#GO:0043231;vacuolar membrane#GO:0005774;vacuole#GO:0005773;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;lytic vacuole#GO:0000323;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;lysosomal membrane#GO:0005765;lysosome#GO:0005764;membrane-bounded organelle#GO:0043227 amino acid transporter#PC00046;transporter#PC00227 HELRO|EnsemblGenome=HelroG77344|UniProtKB=T1G2W5 T1G2W5 20215413 PTHR11246:SF1 PRE-MRNA SPLICING FACTOR PRE-MRNA-PROCESSING FACTOR 6 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;spliceosomal snRNP assembly#GO:0000387;organic substance metabolic process#GO:0071704;mRNA splicing, via spliceosome#GO:0000398;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375 catalytic step 2 spliceosome#GO:0071013;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;U4/U6 x U5 tri-snRNP complex#GO:0046540;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;spliceosomal tri-snRNP complex#GO:0097526;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG90549|UniProtKB=T1G7T0 T1G7T0 20217127 PTHR47958:SF195 ATP-DEPENDENT RNA HELICASE DBP3 RNA HELICASE catalytic activity, acting on RNA#GO:0140098;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640;mRNA binding#GO:0003729 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG192253|UniProtKB=T1FTR6 T1FTR6 20212213 PTHR11289:SF0 BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2 BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;double-strand break repair#GO:0006302;regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA biosynthetic process#GO:2001141;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;recombinational repair#GO:0000725;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;regulation of DNA-templated transcription#GO:0006355;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;double-strand break repair via homologous recombination#GO:0000724;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cellular response to stress#GO:0033554;regulation of metabolic process#GO:0019222;DNA metabolic process#GO:0006259;regulation of cellular metabolic process#GO:0031323 damaged DNA-binding protein#PC00086;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG185883|UniProtKB=T1FNE2 T1FNE2 20210339 PTHR10502:SF102 ANNEXIN ANNEXIN B11 lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488;phosphatidylserine binding#GO:0001786 cytoplasm#GO:0005737;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG88976|UniProtKB=T1G778 T1G778 20216925 PTHR23276:SF2 PROTEIN PRRC1 PROTEIN PRRC1 protein kinase A binding#GO:0051018;protein kinase A regulatory subunit binding#GO:0034237;protein binding#GO:0005515;binding#GO:0005488 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;positive regulation of molecular function#GO:0044093;activation of protein kinase activity#GO:0032147;regulation of catalytic activity#GO:0050790;positive regulation of protein modification process#GO:0031401;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;regulation of kinase activity#GO:0043549;regulation of protein kinase activity#GO:0045859;positive regulation of protein phosphorylation#GO:0001934;positive regulation of phosphorylation#GO:0042327;positive regulation of catalytic activity#GO:0043085;positive regulation of phosphorus metabolic process#GO:0010562;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;positive regulation of protein metabolic process#GO:0051247;positive regulation of phosphate metabolic process#GO:0045937;regulation of macromolecule metabolic process#GO:0060255;positive regulation of protein kinase activity#GO:0045860;regulation of cellular process#GO:0050794;regulation of protein phosphorylation#GO:0001932;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;regulation of phosphorylation#GO:0042325;regulation of transferase activity#GO:0051338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG176276|UniProtKB=T1FAC9 T1FAC9 20205778 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG65191|UniProtKB=T1FY44 T1FY44 20213742 PTHR46002:SF5 EG:114D9.1 PROTEIN-RELATED EF-HAND DOMAIN-CONTAINING PROTEIN-RELATED regulation of sodium ion transmembrane transporter activity#GO:2000649;regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;regulation of sodium ion transport#GO:0002028;regulation of metal ion transport#GO:0010959;positive regulation of molecular function#GO:0044093;regulation of localization#GO:0032879;positive regulation of transport#GO:0051050;regulation of monoatomic cation transmembrane transport#GO:1904062;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of transporter activity#GO:0032411;regulation of transport#GO:0051049;regulation of cellular process#GO:0050794;regulation of molecular function#GO:0065009;biological regulation#GO:0065007;regulation of monoatomic ion transmembrane transporter activity#GO:0032412;regulation of transmembrane transporter activity#GO:0022898;regulation of monoatomic ion transport#GO:0043269;regulation of transporter activity#GO:0032409;positive regulation of biological process#GO:0048518 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG185435|UniProtKB=T1FMT7 T1FMT7 20210136 PTHR13703:SF25 SMAD MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG cis-regulatory region sequence-specific DNA binding#GO:0000987;SMAD binding#GO:0046332;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;protein binding#GO:0005515;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;signal transduction#GO:0007165;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;response to growth factor#GO:0070848;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;cellular response to BMP stimulus#GO:0071773;cell differentiation#GO:0030154;positive regulation of biosynthetic process#GO:0009891;response to endogenous stimulus#GO:0009719;positive regulation of metabolic process#GO:0009893;anatomical structure morphogenesis#GO:0009653;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;response to BMP#GO:0071772;regulation of macromolecule biosynthetic process#GO:0010556;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;signaling#GO:0023052;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;cellular response to endogenous stimulus#GO:0071495;regulation of DNA-templated transcription#GO:0006355;BMP signaling pathway#GO:0030509;cell communication#GO:0007154;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;activin receptor signaling pathway#GO:0032924;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular response to growth factor stimulus#GO:0071363;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;anatomical structure development#GO:0048856;transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0007178;biological regulation#GO:0065007;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 MYO signaling pathway#P06215>SMOX#P06314;Activin beta signaling pathway#P06210>SMOX#P06236;ALP23B signaling pathway#P06209>SMOX#P06224;BMP/activin signaling pathway-drosophila#P06211>R-Smad#P06245;TGF-beta signaling pathway#P00052>RSmads#P01292 HELRO|EnsemblGenome=HelroG102846|UniProtKB=T1EDC3 T1EDC3 20194575 PTHR46770:SF1 HOMEOBOX PROTEIN ORTHOPEDIA HOMEOBOX PROTEIN ORTHOPEDIA nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 cell differentiation#GO:0030154;cellular developmental process#GO:0048869;system development#GO:0048731;neurogenesis#GO:0022008;anatomical structure development#GO:0048856;multicellular organism development#GO:0007275;developmental process#GO:0032502;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;cellular process#GO:0009987;nervous system development#GO:0007399 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG146855|UniProtKB=T1EJV2 T1EJV2 20196852 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG174476|UniProtKB=T1F859 T1F859 20205008 PTHR43404:SF1 LIPOPOLYSACCHARIDE CHOLINEPHOSPHOTRANSFERASE LICD MNN4P transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG106472|UniProtKB=T1EE27 T1EE27 20194829 PTHR11946:SF109 VALYL-TRNA SYNTHETASES VALINE--TRNA LIGASE catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG75655|UniProtKB=T1G284 T1G284 20215182 PTHR14139:SF2 CALSYNTENIN CALSYNTENIN-1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG163048|UniProtKB=T1ETL6 T1ETL6 20199916 PTHR19282:SF534 TETRASPANIN TETRASPANIN FAMILY-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG76744|UniProtKB=T1G2N8 T1G2N8 20215336 PTHR24058:SF103 DUAL SPECIFICITY PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;peptidyl-amino acid modification#GO:0018193;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;peptidyl-threonine phosphorylation#GO:0018107;nitrogen compound metabolic process#GO:0006807;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG140459|UniProtKB=T1EJ09 T1EJ09 20196559 PTHR28670:SF1 UV-STIMULATED SCAFFOLD PROTEIN A UV-STIMULATED SCAFFOLD PROTEIN A basal RNA polymerase II transcription machinery binding#GO:0001099;RNA polymerase binding#GO:0070063;binding#GO:0005488;RNA polymerase core enzyme binding#GO:0043175;RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515;enzyme binding#GO:0019899;basal transcription machinery binding#GO:0001098 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;nucleotide-excision repair#GO:0006289;response to light stimulus#GO:0009416;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;response to stress#GO:0006950;response to UV#GO:0009411;nitrogen compound metabolic process#GO:0006807;response to radiation#GO:0009314;response to abiotic stimulus#GO:0009628;cellular response to stress#GO:0033554;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;metabolic process#GO:0008152 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG90238|UniProtKB=T1G7M9 T1G7M9 20217076 PTHR10093:SF8 IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG IRON-SULFUR CLUSTER ASSEMBLY ENZYME cation binding#GO:0043169;ferrous iron binding#GO:0008198;small molecule binding#GO:0036094;binding#GO:0005488;iron-sulfur cluster binding#GO:0051536;iron ion binding#GO:0005506;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;ion binding#GO:0043167 inorganic ion homeostasis#GO:0098771;intracellular iron ion homeostasis#GO:0006879;intracellular monoatomic cation homeostasis#GO:0030003;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic ion homeostasis#GO:0006873;chemical homeostasis#GO:0048878;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG173158|UniProtKB=T1F6H0 T1F6H0 20204419 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189102|UniProtKB=T1FQN4 T1FQN4 20211131 PTHR21074:SF0 IQ AND UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN IQ AND UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194898|UniProtKB=T1FWJ4 T1FWJ4 20213189 PTHR43544:SF7 SHORT-CHAIN DEHYDROGENASE/REDUCTASE NADB-LER2 oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG67442|UniProtKB=T1FZ09 T1FZ09 20214057 PTHR22957:SF212 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN RELATED TO THE N TERMINUS OF TRE ONCOGENE, ISOFORM A nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;activation of GTPase activity#GO:0090630;biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG86213|UniProtKB=T1G686 T1G686 20216583 PTHR22984:SF25 SERINE/THREONINE-PROTEIN KINASE PIM PROTEIN KINASE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG195129|UniProtKB=T1FWS3 T1FWS3 20213268 PTHR20886:SF11 VANG-LIKE PROTEIN VANG-LIKE PROTEIN signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;epithelium development#GO:0060429;non-canonical Wnt signaling pathway#GO:0035567;developmental process#GO:0032502;cell communication#GO:0007154;cellular process#GO:0009987;cell-cell signaling by wnt#GO:0198738;tissue development#GO:0009888;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;anatomical structure morphogenesis#GO:0009653;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;tissue morphogenesis#GO:0048729;morphogenesis of an epithelium#GO:0002009;cell-cell signaling#GO:0007267;signaling#GO:0023052;Wnt signaling pathway#GO:0016055 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG164985|UniProtKB=T1EW25 T1EW25 20200775 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG96746|UniProtKB=T1G9D5 T1G9D5 20217682 PTHR24412:SF450 KELCH PROTEIN KELCH-LIKE PROTEIN DIABLO scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG96415|UniProtKB=T1G9B9 T1G9B9 20217666 PTHR15696:SF5 SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7 NONSENSE-MEDIATED MRNA DECAY FACTOR SMG7 telomeric DNA binding#GO:0042162;sequence-specific DNA binding#GO:0043565;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;mRNA catabolic process#GO:0006402;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;negative regulation of cellular process#GO:0048523;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;nuclear-transcribed mRNA catabolic process#GO:0000956;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG104674|UniProtKB=T1EDM9 T1EDM9 20194681 PTHR23338:SF17 SMALL NUCLEAR RIBONUCLEOPROTEIN SM SMALL NUCLEAR RIBONUCLEOPROTEIN SM D3 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;organic cyclic compound metabolic process#GO:1901360;mRNA metabolic process#GO:0016071;nitrogen compound metabolic process#GO:0006807;spliceosomal snRNP assembly#GO:0000387;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375 catalytic step 2 spliceosome#GO:0071013;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;U1 snRNP#GO:0005685;U2-type spliceosomal complex#GO:0005684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;U4 snRNP#GO:0005687;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;U5 snRNP#GO:0005682;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;SMN-Sm protein complex#GO:0034719;ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;U2 snRNP#GO:0005686;spliceosomal tri-snRNP complex#GO:0097526;precatalytic spliceosome#GO:0071011;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG156237|UniProtKB=T1ELT1 T1ELT1 20197531 PTHR24410:SF26 HL07962P-RELATED BTB DOMAIN-CONTAINING PROTEIN defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG188027|UniProtKB=T1FPK2 T1FPK2 20210749 PTHR11208:SF42 RNA-BINDING PROTEIN RELATED QUAKING RELATED 54B, ISOFORM E nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of RNA splicing#GO:0043484;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of mRNA processing#GO:0050684;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;regulation of mRNA metabolic process#GO:1903311 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG188133|UniProtKB=T1FPP0 T1FPP0 20210787 PTHR24637:SF428 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG103935|UniProtKB=T1EDI7 T1EDI7 20194639 PTHR22974:SF23 MIXED LINEAGE PROTEIN KINASE TOUSLED-LIKE KINASE, ISOFORM G transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;cell cycle process#GO:0022402;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;chromosome segregation#GO:0007059;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell cycle#GO:0007049;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG192836|UniProtKB=T1FUC4 T1FUC4 20212420 PTHR11089:SF9 GTP-BINDING PROTEIN-RELATED NUCLEOLAR GTP-BINDING PROTEIN 2 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG187216|UniProtKB=T1FP78 T1FP78 20210625 PTHR42908:SF3 TRANSLATION ELONGATION FACTOR-RELATED ELONGATION FACTOR-LIKE GTPASE 1 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;nucleic acid binding#GO:0003676;translation regulator activity#GO:0045182;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;translation regulator activity, nucleic acid binding#GO:0090079;translation elongation factor activity#GO:0003746;translation factor activity, RNA binding#GO:0008135 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;translational elongation#GO:0006414;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 translation elongation factor#PC00222 HELRO|EnsemblGenome=HelroG185660|UniProtKB=T1FN37 T1FN37 20210235 PTHR23306:SF3 TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED TUMOR SUPPRESSOR PROTEIN 101 protein binding#GO:0005515;ubiquitin-like protein binding#GO:0032182;binding#GO:0005488;ubiquitin binding#GO:0043130 localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;vacuolar transport#GO:0007034;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;endosome to lysosome transport#GO:0008333;cellular process#GO:0009987;lysosomal transport#GO:0007041 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endosome membrane#GO:0010008;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ESCRT I complex#GO:0000813;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle membrane#GO:0030659 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG169288|UniProtKB=T1F1Q6 T1F1Q6 20202756 PTHR33273:SF4 DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171575|UniProtKB=T1F4F0 T1F4F0 20203699 PTHR45982:SF1 REGULATOR OF CHROMOSOME CONDENSATION REGULATOR OF CHROMOSOME CONDENSATION HELRO|EnsemblGenome=HelroG110726|UniProtKB=T1EF45 T1EF45 20195197 PTHR24418:SF373 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE SRC42A protein tyrosine kinase activity#GO:0004713;non-membrane spanning protein tyrosine kinase activity#GO:0004715;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein binding#GO:0005515;catalytic activity, acting on a protein#GO:0140096;signaling receptor binding#GO:0005102;kinase activity#GO:0016301;protein kinase activity#GO:0004672 response to external biotic stimulus#GO:0043207;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;immune response#GO:0006955;developmental process#GO:0032502;cell communication#GO:0007154;cellular process#GO:0009987;defense response to symbiont#GO:0140546;regulation of biological process#GO:0050789;immune system process#GO:0002376;response to stimulus#GO:0050896;response to external stimulus#GO:0009605;cell differentiation#GO:0030154;enzyme-linked receptor protein signaling pathway#GO:0007167;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to other organism#GO:0098542;regulation of cellular process#GO:0050794;response to other organism#GO:0051707;cell surface receptor signaling pathway#GO:0007166;biological process involved in interspecies interaction between organisms#GO:0044419;biological regulation#GO:0065007;innate immune response#GO:0045087;defense response#GO:0006952;signaling#GO:0023052;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169 non-receptor tyrosine protein kinase#PC00168 Parkinson disease#P00049>Src kinase#P01230;Integrin signalling pathway#P00034>Src#P00940 HELRO|EnsemblGenome=HelroG192110|UniProtKB=T1FTL0 T1FTL0 20212157 PTHR47969:SF15 CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED cytoskeletal motor activity#GO:0003774;microtubule motor activity#GO:0003777;ATP-dependent activity#GO:0140657 nuclear chromosome segregation#GO:0098813;mitotic spindle organization#GO:0007052;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular process#GO:0009987;spindle elongation#GO:0051231;mitotic cell cycle process#GO:1903047;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;cell cycle#GO:0007049;spindle organization#GO:0007051 intracellular non-membrane-bounded organelle#GO:0043232;microtubule associated complex#GO:0005875;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG167607|UniProtKB=T1EZJ7 T1EZJ7 20201997 PTHR48112:SF22 HIGH MOBILITY GROUP PROTEIN DSP1 MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG185544|UniProtKB=T1FMY7 T1FMY7 20210186 PTHR15430:SF1 GLOMULIN GLOMULIN enzyme inhibitor activity#GO:0004857;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG103091|UniProtKB=T1EDE3 T1EDE3 20194595 PTHR24189:SF71 MYOTROPHIN ANKYRIN REPEAT DOMAIN 39 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG79940|UniProtKB=T1G3V4 T1G3V4 20215752 PTHR11256:SF41 BCL-2 RELATED BCL-2 HOMOLOGOUS ANTAGONIST_KILLER wide pore channel activity#GO:0022829;protein binding#GO:0005515;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;channel activity#GO:0015267;binding#GO:0005488 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of cysteine-type endopeptidase activity involved in apoptotic process#GO:0043280;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;signal transduction#GO:0007165;positive regulation of cysteine-type endopeptidase activity#GO:2001056;regulation of protein metabolic process#GO:0051246;apoptotic mitochondrial changes#GO:0008637;regulation of cysteine-type endopeptidase activity#GO:2000116;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;positive regulation of proteolysis#GO:0045862;regulation of biological process#GO:0050789;activation of cysteine-type endopeptidase activity involved in apoptotic process#GO:0006919;DNA damage response#GO:0006974;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;apoptotic process#GO:0006915;cell death#GO:0008219;regulation of hydrolase activity#GO:0051336;mitochondrion organization#GO:0007005;intracellular signal transduction#GO:0035556;positive regulation of biological process#GO:0048518;positive regulation of peptidase activity#GO:0010952;signaling#GO:0023052;regulation of proteolysis#GO:0030162;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;programmed cell death#GO:0012501;cell communication#GO:0007154;cellular component organization#GO:0016043;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of hydrolase activity#GO:0051345;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;intrinsic apoptotic signaling pathway#GO:0097193;apoptotic signaling pathway#GO:0097190;response to stimulus#GO:0050896;positive regulation of protein metabolic process#GO:0051247;response to stress#GO:0006950;extrinsic apoptotic signaling pathway#GO:0097191;regulation of macromolecule metabolic process#GO:0060255;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;regulation of endopeptidase activity#GO:0052548;regulation of cysteine-type endopeptidase activity involved in apoptotic process#GO:0043281;regulation of peptidase activity#GO:0052547;release of cytochrome c from mitochondria#GO:0001836;cellular response to stress#GO:0033554;positive regulation of endopeptidase activity#GO:0010950;regulation of metabolic process#GO:0019222 bounding membrane of organelle#GO:0098588;envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial outer membrane#GO:0005741;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867 Apoptosis signaling pathway#P00006>Bak#P00275 HELRO|EnsemblGenome=HelroG71412|UniProtKB=T1G0L2 T1G0L2 20214610 PTHR10442:SF0 40S RIBOSOMAL PROTEIN S21 SMALL RIBOSOMAL SUBUNIT PROTEIN ES21 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;ribosome biogenesis#GO:0042254;maturation of 5.8S rRNA#GO:0000460;endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000447;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;cytosol#GO:0005829;small ribosomal subunit#GO:0015935;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG62457|UniProtKB=T1FX09 T1FX09 20213357 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192166|UniProtKB=T1FTN2 T1FTN2 20212179 PTHR46051:SF1 SH2 DOMAIN-CONTAINING PROTEIN INOSITOL POLYPHOSPHATE-RELATED PHOSPHATASE DOMAIN-CONTAINING PROTEIN regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;regulation of immune response#GO:0050776;regulation of signaling#GO:0023051;biological regulation#GO:0065007;regulation of immune system process#GO:0002682 HELRO|EnsemblGenome=HelroG172496|UniProtKB=T1F5E7 T1F5E7 20204046 PTHR48134:SF2 GLYCOPROTEIN 96-92-RELATED-RELATED OS04G0609100 PROTEIN HELRO|EnsemblGenome=HelroG68132|UniProtKB=T1FZA7 T1FZA7 20214155 PTHR24058:SF28 DUAL SPECIFICITY PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE MINIBRAIN transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;peptidyl-amino acid modification#GO:0018193;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;peptidyl-threonine phosphorylation#GO:0018107;nitrogen compound metabolic process#GO:0006807;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG168207|UniProtKB=T1F0B2 T1F0B2 20202262 PTHR10642:SF26 RIBONUCLEASE H1 RIBONUCLEASE H1 catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular nitrogen compound catabolic process#GO:0044270;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic cyclic compound catabolic process#GO:1901361;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;organic substance catabolic process#GO:1901575;nucleobase-containing compound catabolic process#GO:0034655;DNA replication#GO:0006260;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;cellular catabolic process#GO:0044248 endoribonuclease#PC00094;RNA metabolism protein#PC00031 DNA replication#P00017>RNase H#P00538 HELRO|EnsemblGenome=HelroG90130|UniProtKB=T1G7L5 T1G7L5 20217062 PTHR10068:SF14 BONE MARROW PROTEOGLYCAN CELL WALL ADHESIN EAP1 extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG161907|UniProtKB=T1ES11 T1ES11 20199361 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG89686|UniProtKB=T1G7F7 T1G7F7 20217004 PTHR11792:SF17 ARRESTIN KURTZ ARRESTIN protein binding#GO:0005515;G protein-coupled receptor binding#GO:0001664;binding#GO:0005488;signaling receptor binding#GO:0005102 regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;negative regulation of response to stimulus#GO:0048585;receptor internalization#GO:0031623;negative regulation of signaling#GO:0023057;transport#GO:0006810;endocytosis#GO:0006897;regulation of signaling#GO:0023051;vesicle-mediated transport#GO:0016192;regulation of G protein-coupled receptor signaling pathway#GO:0008277;cellular process#GO:0009987;localization#GO:0051179;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;receptor-mediated endocytosis#GO:0006898;negative regulation of cell communication#GO:0010648;negative regulation of cellular process#GO:0048523;import into cell#GO:0098657 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 Wnt signaling pathway#P00057>beta-arrestin#P01456;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>beta-arrestin#P00880;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>beta-arrestin#P00723 HELRO|EnsemblGenome=HelroG163653|UniProtKB=T1EUB7 T1EUB7 20200167 PTHR11852:SF0 PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB SUBUNIT BETA HOMOLOG protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG183282|UniProtKB=T1FJE7 T1FJE7 20208946 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG71642|UniProtKB=T1G0P6 T1G0P6 20214644 PTHR28661:SF1 SJOEGREN SYNDROME NUCLEAR AUTOANTIGEN 1 MICROTUBULE NUCLEATION FACTOR SSNA1 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cilium#GO:0005929;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG179547|UniProtKB=T1FEV1 T1FEV1 20207350 PTHR22588:SF3 VWFA DOMAIN-CONTAINING PROTEIN VWFA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG187353|UniProtKB=T1FP92 T1FP92 20210639 PTHR46180:SF1 VINCULIN VINCULIN protein binding#GO:0005515;binding#GO:0005488;beta-catenin binding#GO:0008013 cell adhesion#GO:0007155;cellular process#GO:0009987 cell-cell junction#GO:0005911;anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;focal adhesion#GO:0005925;cell-substrate junction#GO:0030055;adherens junction#GO:0005912;cell-cell contact zone#GO:0044291;cytoskeleton#GO:0005856;plasma membrane#GO:0005886 Gonadotropin-releasing hormone receptor pathway#P06664>Vinculin#P06771;Integrin signalling pathway#P00034>Vinculin#P00937 HELRO|EnsemblGenome=HelroG156879|UniProtKB=T1EM25 T1EM25 20197625 PTHR43128:SF16 L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)) L-LACTATE DEHYDROGENASE oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 organic hydroxy compound metabolic process#GO:1901615;oxoacid metabolic process#GO:0043436;cellular metabolic process#GO:0044237;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG125459|UniProtKB=T1EH61 T1EH61 20195911 PTHR47023:SF1 SEX PEPTIDE RECEPTOR SEX PEPTIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG114306|UniProtKB=T1EG08 T1EG08 20195510 PTHR13183:SF0 AXONEMAL INNER ARM DYNEIN LIGHT CHAIN 28 AXONEMAL DYNEIN LIGHT INTERMEDIATE POLYPEPTIDE 1 protein binding#GO:0005515;binding#GO:0005488 axoneme#GO:0005930;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;plasma membrane bounded cell projection cytoplasm#GO:0032838;ciliary plasm#GO:0097014;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cytoskeleton#GO:0005856;cilium#GO:0005929 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG75856|UniProtKB=T1G2B3 T1G2B3 20215211 PTHR10694:SF33 LYSINE-SPECIFIC DEMETHYLASE LYSINE-SPECIFIC DEMETHYLASE 5 histone modifying activity#GO:0140993;demethylase activity#GO:0032451;catalytic activity, acting on a protein#GO:0140096;histone demethylase activity#GO:0032452;catalytic activity#GO:0003824 protein-DNA complex organization#GO:0071824;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;protein-containing complex organization#GO:0043933;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG180473|UniProtKB=T1FFZ1 T1FFZ1 20207740 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG185160|UniProtKB=T1FMG5 T1FMG5 20210014 PTHR12411:SF917 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN L cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197 macromolecule catabolic process#GO:0009057;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;proteolysis#GO:0006508;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;catabolic process#GO:0009056;organonitrogen compound catabolic process#GO:1901565;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;lysosome#GO:0005764;intracellular membrane-bounded organelle#GO:0043231;extracellular region#GO:0005576;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;organelle#GO:0043226;lytic vacuole#GO:0000323;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG110029|UniProtKB=T1EEY4 T1EEY4 20195136 PTHR11328:SF28 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 12 localization#GO:0051179;organic substance transport#GO:0071702;establishment of localization#GO:0051234;transport#GO:0006810 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG170261|UniProtKB=T1F2U6 T1F2U6 20203145 PTHR24258:SF116 SERINE PROTEASE-RELATED FI16631P1-RELATED serine protease#PC00203 HELRO|EnsemblGenome=HelroG70532|UniProtKB=T1G077 T1G077 20214475 PTHR24082:SF283 NUCLEAR HORMONE RECEPTOR NUCLEAR HORMONE RECEPTOR HR96 cis-regulatory region sequence-specific DNA binding#GO:0000987;signaling receptor activity#GO:0038023;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of RNA metabolic process#GO:0051253;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of transcription by RNA polymerase II#GO:0000122;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;cellular developmental process#GO:0048869;negative regulation of biosynthetic process#GO:0009890;regulation of DNA-templated transcription#GO:0006355;negative regulation of metabolic process#GO:0009892;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;negative regulation of nitrogen compound metabolic process#GO:0051172;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG189633|UniProtKB=T1FR80 T1FR80 20211327 PTHR46035:SF1 TETRATRICOPEPTIDE REPEAT PROTEIN 4 TETRATRICOPEPTIDE REPEAT PROTEIN 4 protein binding#GO:0005515;heat shock protein binding#GO:0031072;protein-folding chaperone binding#GO:0051087;binding#GO:0005488;Hsp70 protein binding#GO:0030544;Hsp90 protein binding#GO:0051879 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG158461|UniProtKB=T1EMT5 T1EMT5 20197885 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG69165|UniProtKB=T1FZQ3 T1FZQ3 20214301 PTHR11685:SF210 RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE ARIH2 ubiquitin-like protein conjugating enzyme binding#GO:0044390;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;enzyme binding#GO:0019899;protein binding#GO:0005515;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG188276|UniProtKB=T1FPT8 T1FPT8 20210835 PTHR12387:SF0 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 peptidase complex#GO:1905368;proteasome accessory complex#GO:0022624;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;proteasome regulatory particle#GO:0005838;catalytic complex#GO:1902494;proteasome regulatory particle, lid subcomplex#GO:0008541;proteasome complex#GO:0000502;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endopeptidase complex#GO:1905369;membrane-bounded organelle#GO:0043227 protease#PC00190;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG158328|UniProtKB=T1EMN8 T1EMN8 20197838 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED BRCT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158300|UniProtKB=T1EML9 T1EML9 20197819 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG153507|UniProtKB=T1EL83 T1EL83 20197333 PTHR21454:SF31 DPH3 HOMOLOG-RELATED DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3 HELRO|EnsemblGenome=HelroG192174|UniProtKB=T1FTN6 T1FTN6 20212183 PTHR20957:SF0 RNA-BINDING PROTEIN 48 RNA-BINDING PROTEIN 48 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG85646|UniProtKB=T1G611 T1G611 20216508 PTHR14604:SF3 WD40 REPEAT PF20 SPERM-ASSOCIATED ANTIGEN 16 PROTEIN microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG63157|UniProtKB=T1FXB8 T1FXB8 20213466 PTHR15241:SF386 TRANSFORMER-2-RELATED RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN-RELATED RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG78031|UniProtKB=T1G370 T1G370 20215518 PTHR15350:SF5 COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17 COP9 SIGNALOSOME COMPLEX SUBUNIT 7 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;COP9 signalosome#GO:0008180;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG84106|UniProtKB=T1G5E9 T1G5E9 20216296 PTHR24240:SF85 OPSIN OPSIN RH1-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;response to light stimulus#GO:0009416;cellular response to stimulus#GO:0051716;detection of stimulus#GO:0051606;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to external stimulus#GO:0009605;regulation of cellular process#GO:0050794;response to radiation#GO:0009314;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;response to abiotic stimulus#GO:0009628;signaling#GO:0023052;cellular response to light stimulus#GO:0071482 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Rhodopsin#P00747 HELRO|EnsemblGenome=HelroG167446|UniProtKB=T1EZE1 T1EZE1 20201941 PTHR11103:SF10 SLR1189 PROTEIN HOMOCYSTEINE S-METHYLTRANSFERASE 1-RELATED Methionine biosynthesis#P02753>Homocysteine transmethylase#P03024;Formyltetrahydrofolate biosynthesis#P02743>Cobalamin dependent homocysteine transmethylase#P02953 HELRO|EnsemblGenome=HelroG62224|UniProtKB=T1FWX3 T1FWX3 20213321 PTHR43475:SF1 METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE isomerase activity#GO:0016853;catalytic activity#GO:0003824 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;sulfur compound metabolic process#GO:0006790;proteinogenic amino acid biosynthetic process#GO:0170038;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;aspartate family amino acid biosynthetic process#GO:0009067;alpha-amino acid biosynthetic process#GO:1901607;nitrogen compound metabolic process#GO:0006807;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;aspartate family amino acid metabolic process#GO:0009066;small molecule biosynthetic process#GO:0044283;L-amino acid biosynthetic process#GO:0170034;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 isomerase#PC00135;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG186326|UniProtKB=T1FNY6 T1FNY6 20210533 PTHR23139:SF9 RNA-BINDING PROTEIN SPLICING FACTOR U2AF 65 KDA SUBUNIT nucleic acid binding#GO:0003676;single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723;pre-mRNA binding#GO:0036002;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375;spliceosomal complex assembly#GO:0000245 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;U2-type spliceosomal complex#GO:0005684;nuclear speck#GO:0016607;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear body#GO:0016604;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;U2-type prespliceosome#GO:0071004;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG185090|UniProtKB=T1FMD8 T1FMD8 20209987 PTHR19282:SF534 TETRASPANIN TETRASPANIN FAMILY-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG175328|UniProtKB=T1F952 T1F952 20205351 PTHR23204:SF10 CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 6 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;mRNA 3'-end processing#GO:0031124;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mRNA processing#GO:0006397;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;mRNA cleavage factor complex#GO:0005849;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG190413|UniProtKB=T1FRZ1 T1FRZ1 20211588 PTHR24020:SF84 COLLAGEN ALPHA VWFA DOMAIN-CONTAINING PROTEIN extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG108883|UniProtKB=T1EEN4 T1EEN4 20195036 PTHR13462:SF10 CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;secondary active transmembrane transporter activity#GO:0015291;inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;inorganic cation transmembrane transporter activity#GO:0022890 inorganic ion homeostasis#GO:0098771;metal ion transport#GO:0030001;calcium ion homeostasis#GO:0055074;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;inorganic ion transmembrane transport#GO:0098660;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;calcium ion transport#GO:0006816;intracellular calcium ion homeostasis#GO:0006874;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;mitochondrial transport#GO:0006839;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation transport#GO:0006812;mitochondrial calcium ion homeostasis#GO:0051560;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;mitochondrial transmembrane transport#GO:1990542;monoatomic cation transmembrane transport#GO:0098655 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;transporter complex#GO:1990351;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;calcium channel complex#GO:0034704;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;cation channel complex#GO:0034703;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;mitochondrial envelope#GO:0005740;transmembrane transporter complex#GO:1902495;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;mitochondrial protein-containing complex#GO:0098798 HELRO|EnsemblGenome=HelroG190322|UniProtKB=T1FRW8 T1FRW8 20211565 PTHR13140:SF860 MYOSIN MYOSIN MOTOR DOMAIN-CONTAINING PROTEIN microfilament motor activity#GO:0000146;cytoskeletal protein binding#GO:0008092;ATP-dependent activity#GO:0140657;binding#GO:0005488;actin filament binding#GO:0051015;cytoskeletal motor activity#GO:0003774;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG171835|UniProtKB=T1F4R8 T1F4R8 20203817 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG179215|UniProtKB=T1FED2 T1FED2 20207181 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG62159|UniProtKB=T1FWW4 T1FWW4 20213312 PTHR24372:SF80 GLYCOPROTEIN HORMONE RECEPTOR FI21465P1-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 response to organic substance#GO:0010033;positive regulation of adenylate cyclase activity#GO:0045762;regulation of lyase activity#GO:0051339;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;cellular response to stimulus#GO:0051716;regulation of adenylate cyclase activity#GO:0045761;signal transduction#GO:0007165;cellular response to endogenous stimulus#GO:0071495;cellular response to chemical stimulus#GO:0070887;positive regulation of catalytic activity#GO:0043085;cellular response to organic substance#GO:0071310;regulation of cyclase activity#GO:0031279;positive regulation of molecular function#GO:0044093;cell communication#GO:0007154;regulation of catalytic activity#GO:0050790;cellular process#GO:0009987;positive regulation of cyclase activity#GO:0031281;hormone-mediated signaling pathway#GO:0009755;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to endogenous stimulus#GO:0009719;response to hormone#GO:0009725;cellular response to hormone stimulus#GO:0032870;response to chemical#GO:0042221;regulation of molecular function#GO:0065009;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;positive regulation of lyase activity#GO:0051349;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG184509|UniProtKB=T1FLC8 T1FLC8 HELRODRAFT_184509 PTHR43507:SF1 NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4 NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4 NADH dehydrogenase activity#GO:0003954;oxidoreductase activity, acting on NAD(P)H#GO:0016651;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 aerobic respiration#GO:0009060;cellular respiration#GO:0045333;transmembrane transport#GO:0055085;proton transmembrane transport#GO:1902600;inorganic cation transmembrane transport#GO:0098662;generation of precursor metabolites and energy#GO:0006091;transport#GO:0006810;cellular metabolic process#GO:0044237;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;energy derivation by oxidation of organic compounds#GO:0015980;localization#GO:0051179;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;metabolic process#GO:0008152 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG138704|UniProtKB=T1EIW6 T1EIW6 20196516 PTHR19290:SF164 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED BHLH DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;neurogenesis#GO:0022008;positive regulation of RNA biosynthetic process#GO:1902680;cell projection organization#GO:0030030;regulation of nitrogen compound metabolic process#GO:0051171;animal organ development#GO:0048513;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;regulation of biological process#GO:0050789;system development#GO:0048731;cell differentiation#GO:0030154;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;neuron differentiation#GO:0030182;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;multicellular organism development#GO:0007275;cellular component organization#GO:0016043;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;anatomical structure development#GO:0048856;biological regulation#GO:0065007;neuron development#GO:0048666;multicellular organismal process#GO:0032501;positive regulation of RNA metabolic process#GO:0051254;generation of neurons#GO:0048699;sensory organ development#GO:0007423;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG78675|UniProtKB=T1G3E4 T1G3E4 20215592 PTHR23235:SF165 KRUEPPEL-LIKE TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR BTD sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG179442|UniProtKB=T1FEQ1 T1FEQ1 20207300 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG161741|UniProtKB=T1ERV1 T1ERV1 20199301 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG63997|UniProtKB=T1FXN3 T1FXN3 20213581 PTHR20920:SF5 RPE-SPONDIN SMB DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191328|UniProtKB=T1FSW1 T1FSW1 20211908 PTHR22654:SF2 G PROTEIN PATHWAY SUPPRESSOR 2 G PROTEIN PATHWAY SUPPRESSOR 2 molecular adaptor activity#GO:0060090;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;protein-macromolecule adaptor activity#GO:0030674 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG185497|UniProtKB=T1FMW3 T1FMW3 20210162 PTHR45883:SF2 HSC70-INTERACTING PROTEIN HSC70-INTERACTING PROTEIN protein binding#GO:0005515;heat shock protein binding#GO:0031072;protein-folding chaperone binding#GO:0051087;binding#GO:0005488;Hsp70 protein binding#GO:0030544 macromolecule biosynthetic process#GO:0009059;chaperone-mediated protein folding#GO:0061077;chaperone cofactor-dependent protein refolding#GO:0051085;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;'de novo' protein folding#GO:0006458;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG77866|UniProtKB=T1G349 T1G349 20215497 PTHR42985:SF40 SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER LD47995P-RELATED symporter activity#GO:0015293;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;monoatomic cation transport#GO:0006812;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG142283|UniProtKB=T1EJ53 T1EJ53 20196603 PTHR24241:SF76 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR NEUROPEPTIDE SIFAMIDE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;binding#GO:0005488;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888;amide binding#GO:0033218 response to organic substance#GO:0010033;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;response to hormone#GO:0009725;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG171057|UniProtKB=T1F3R9 T1F3R9 20203468 PTHR24127:SF1 ANKYRIN REPEAT AND EF-HAND DOMAIN-CONTAINING PROTEIN 1 ANKYRIN REPEAT AND EF-HAND DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG104295|UniProtKB=T1EDK8 T1EDK8 20194660 PTHR45810:SF10 HISTONE H3.2 HISTONE H3 chromatin/chromatin-binding, or -regulatory protein#PC00077 DNA replication#P00017>Histones#P00527 HELRO|EnsemblGenome=HelroG178672|UniProtKB=T1FDJ7 T1FDJ7 20206896 PTHR10270:SF161 SOX TRANSCRIPTION FACTOR SEX-DETERMINING REGION Y PROTEIN DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;cell differentiation#GO:0030154;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG189453|UniProtKB=T1FR27 T1FR27 20211274 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG70969|UniProtKB=T1G0F1 T1G0F1 20214549 PTHR24092:SF190 PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE PHOSPHOLIPID-TRANSPORTING ATPASE ATPase-coupled intramembrane lipid transporter activity#GO:0140326;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;lipid transporter activity#GO:0005319 organophosphate ester transport#GO:0015748;Golgi organization#GO:0007030;macromolecule localization#GO:0033036;membrane organization#GO:0061024;transport#GO:0006810;endomembrane system organization#GO:0010256;cellular component organization#GO:0016043;regulation of membrane lipid distribution#GO:0097035;phospholipid transport#GO:0015914;cellular process#GO:0009987;lipid transport#GO:0006869;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;organelle organization#GO:0006996;biological regulation#GO:0065007;lipid translocation#GO:0034204;lipid localization#GO:0010876;phospholipid translocation#GO:0045332 cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi apparatus subcompartment#GO:0098791;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG182172|UniProtKB=T1FHV2 T1FHV2 20208401 PTHR24041:SF30 MUCIN MUCIN-3A cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG108413|UniProtKB=T1EEI7 T1EEI7 20194989 PTHR12258:SF5 JANUS-A/JANUS-B BCDNA.GH02250-RELATED hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;dephosphorylation#GO:0016311;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG179856|UniProtKB=T1FF77 T1FF77 20207476 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG68699|UniProtKB=T1FZI5 T1FZI5 20214233 PTHR24115:SF789 KINESIN-RELATED KINESIN-LIKE PROTEIN KLP68D pyrophosphatase activity#GO:0016462;cytoskeletal protein binding#GO:0008092;microtubule motor activity#GO:0003777;tubulin binding#GO:0015631;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;cytoskeletal motor activity#GO:0003774;microtubule binding#GO:0008017;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;microtubule associated complex#GO:0005875;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG64498|UniProtKB=T1FXV5 T1FXV5 20213653 PTHR12934:SF11 50S RIBOSOMAL PROTEIN L15 LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG184272|UniProtKB=T1FKW3 T1FKW3 20209462 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG185521|UniProtKB=T1FMX5 T1FMX5 20210174 PTHR13902:SF67 SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED NUCLEAR RECEPTOR-BINDING PROTEIN HOMOLOG transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG187046|UniProtKB=T1FP61 T1FP61 20210608 PTHR43127:SF1 DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2 DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 1 carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cytoplasmic translation#GO:0002181;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG194670|UniProtKB=T1FWA7 T1FWA7 20213103 PTHR10337:SF6 SHC TRANSFORMING PROTEIN CENTROSOMAL PROTEIN OF 152 KDA scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG87690|UniProtKB=T1G6U3 T1G6U3 20216790 PTHR47537:SF2 CUBILIN CUBILIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG111386|UniProtKB=T1EFA8 T1EFA8 20195260 PTHR25462:SF296 BONUS, ISOFORM C-RELATED MEIOTIC P26, ISOFORM F ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG175740|UniProtKB=T1F9M0 T1F9M0 20205519 PTHR24073:SF315 DRAB5-RELATED RAS-RELATED PROTEIN RAB-7L1 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;pigmentation#GO:0043473;nitrogen compound transport#GO:0071705;cellular component organization#GO:0016043;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;organelle organization#GO:0006996;protein transport#GO:0015031;melanosome organization#GO:0032438;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;vesicle organization#GO:0016050;intracellular transport#GO:0046907 trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;organelle subcompartment#GO:0031984;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;melanosome#GO:0042470;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;Golgi apparatus subcompartment#GO:0098791 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG85110|UniProtKB=T1G5S9 T1G5S9 20216426 PTHR11675:SF119 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2 transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG158768|UniProtKB=T1EN87 T1EN87 20198037 PTHR28624:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 51 MITOCHONDRIAL POTASSIUM CHANNEL HELRO|EnsemblGenome=HelroG184858|UniProtKB=T1FM34 T1FM34 20209883 PTHR11604:SF0 PROFILIN PROFILIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;actin binding#GO:0003779;binding#GO:0005488;actin monomer binding#GO:0003785 negative regulation of protein polymerization#GO:0032272;cellular localization#GO:0051641;negative regulation of biological process#GO:0048519;macromolecule localization#GO:0033036;regulation of cellular component organization#GO:0051128;regulation of actin polymerization or depolymerization#GO:0008064;regulation of biological process#GO:0050789;regulation of cytoskeleton organization#GO:0051493;regulation of protein-containing complex assembly#GO:0043254;regulation of biological quality#GO:0065008;regulation of cellular component biogenesis#GO:0044087;negative regulation of organelle organization#GO:0010639;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament-based process#GO:0032970;negative regulation of cellular component organization#GO:0051129;regulation of protein polymerization#GO:0032271;negative regulation of cellular process#GO:0048523;regulation of anatomical structure size#GO:0090066;regulation of actin filament length#GO:0030832;regulation of organelle organization#GO:0033043;regulation of actin filament organization#GO:0110053;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of actin filament polymerization#GO:0030833;regulation of cellular component size#GO:0032535;protein localization#GO:0008104;negative regulation of supramolecular fiber organization#GO:1902904;regulation of supramolecular fiber organization#GO:1902903;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;cellular macromolecule localization#GO:0070727;maintenance of location#GO:0051235;regulation of cellular process#GO:0050794;maintenance of location in cell#GO:0051651;negative regulation of actin filament polymerization#GO:0030837;biological regulation#GO:0065007;negative regulation of protein-containing complex assembly#GO:0031333;negative regulation of cytoskeleton organization#GO:0051494 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;cell cortex#GO:0005938;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 Cytoskeletal regulation by Rho GTPase#P00016>Profilin#P00521 HELRO|EnsemblGenome=HelroG177122|UniProtKB=T1FB91 T1FB91 20206090 PTHR46704:SF9 CXC DOMAIN-CONTAINING PROTEIN-RELATED BHLH DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178297|UniProtKB=T1FD21 T1FD21 20206720 PTHR21437:SF1 WIDE AWAKE WIDE AWAKE HELRO|EnsemblGenome=HelroG71023|UniProtKB=T1G0F9 T1G0F9 20214557 PTHR11309:SF35 FRIZZLED PROTEIN SMOOTHENED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;protein binding#GO:0005515;Wnt-protein binding#GO:0017147;signaling receptor binding#GO:0005102;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888 neuron projection guidance#GO:0097485;signal transduction#GO:0007165;neurogenesis#GO:0022008;cell projection organization#GO:0030030;smoothened signaling pathway#GO:0007224;developmental process#GO:0032502;non-canonical Wnt signaling pathway#GO:0035567;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;regulation of biological process#GO:0050789;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;central nervous system development#GO:0007417;axonogenesis#GO:0007409;plasma membrane bounded cell projection morphogenesis#GO:0120039;pattern specification process#GO:0007389;cell-cell signaling#GO:0007267;signaling#GO:0023052;canonical Wnt signaling pathway#GO:0060070;Wnt signaling pathway#GO:0016055;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;multicellular organism development#GO:0007275;cell communication#GO:0007154;cell morphogenesis#GO:0000902;cellular component organization#GO:0016043;cellular process#GO:0009987;cell-cell signaling by wnt#GO:0198738;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;response to stimulus#GO:0050896;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;anatomical structure development#GO:0048856;biological regulation#GO:0065007;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 somatodendritic compartment#GO:0036477;neuron projection#GO:0043005;dendrite#GO:0030425;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;dendritic tree#GO:0097447;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;cilium#GO:0005929;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Hedgehog signaling pathway#P00025>Smoothened#P00685 HELRO|EnsemblGenome=HelroG192173|UniProtKB=T1FTN5 T1FTN5 20212182 PTHR46534:SF1 IGGFC_BINDING DOMAIN-CONTAINING PROTEIN IGGFC-BINDING PROTEIN N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG82463|UniProtKB=T1G4S5 T1G4S5 20216073 PTHR10183:SF433 CALPAIN CALPAIN-A-RELATED cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protease#PC00190 Huntington disease#P00029>Calpain#P00788 HELRO|EnsemblGenome=HelroG72364|UniProtKB=T1G0Y9 T1G0Y9 20214737 PTHR12062:SF9 N-ACETYLGLUCOSAMINYLTRANSFERASE VI ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE A, ISOFORM A acetylglucosaminyltransferase activity#GO:0008375;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi apparatus subcompartment#GO:0098791;cellular anatomical entity#GO:0110165;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;Golgi stack#GO:0005795;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG192438|UniProtKB=T1FTY7 T1FTY7 20212284 PTHR11412:SF136 MACROGLOBULIN / COMPLEMENT CD109 ANTIGEN protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG186166|UniProtKB=T1FNR4 T1FNR4 20210461 PTHR11558:SF11 SPERMIDINE/SPERMINE SYNTHASE SPERMIDINE SYNTHASE transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG176211|UniProtKB=T1FAA8 T1FAA8 20205757 PTHR45779:SF7 PEPTIDYLPROLYL ISOMERASE PEPTIDYLPROLYL ISOMERASE TGF-beta signaling pathway#P00052>FKBP12#P01288 HELRO|EnsemblGenome=HelroG62465|UniProtKB=T1FX11 T1FX11 20213359 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG65081|UniProtKB=T1FY31 T1FY31 20213729 PTHR16222:SF26 ADP-RIBOSYLGLYCOHYDROLASE ADP-RIBOSYLHYDROLASE ARH1 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG155691|UniProtKB=T1ELK6 T1ELK6 20197456 PTHR47448:SF1 DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG185922|UniProtKB=T1FNG0 T1FNG0 20210357 PTHR24073:SF471 DRAB5-RELATED RAS-RELATED PROTEIN RAB-24 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 localization#GO:0051179;organic substance transport#GO:0071702;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;protein transport#GO:0015031;nitrogen compound transport#GO:0071705;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;endocytic vesicle#GO:0030139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;autophagosome#GO:0005776;intracellular anatomical structure#GO:0005622 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG169089|UniProtKB=T1F1D6 T1F1D6 20202636 PTHR23424:SF23 SERUM AMYLOID A PROTEIN SAAL1 apolipoprotein#PC00052;transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG187659|UniProtKB=T1FPB6 T1FPB6 20210663 PTHR13720:SF14 WD-40 REPEAT PROTEIN CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 52 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG185546|UniProtKB=T1FMY9 T1FMY9 20210188 PTHR12396:SF0 METHYL-CPG BINDING PROTEIN, MBD METHYL-CPG BINDING DOMAIN PROTEIN-LIKE, ISOFORM C chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG191640|UniProtKB=T1FT58 T1FT58 20212005 PTHR10845:SF192 REGULATOR OF G PROTEIN SIGNALING DOUBLE HIT, ISOFORM B G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731 HELRO|EnsemblGenome=HelroG106514|UniProtKB=T1EE30 T1EE30 20194832 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG185302|UniProtKB=T1FMN0 T1FMN0 20210079 PTHR19359:SF150 CYTOCHROME B5 CYTOCHROME B5 tetrapyrrole binding#GO:0046906;binding#GO:0005488;organic cyclic compound binding#GO:0097159;heme binding#GO:0020037 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG172268|UniProtKB=T1F562 T1F562 20203961 PTHR45805:SF2 NUCLEAR HORMONE RECEPTOR HR3-RELATED NUCLEAR HORMONE RECEPTOR HR3-RELATED cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;signaling receptor activity#GO:0038023;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG188563|UniProtKB=T1FQ46 T1FQ46 20210943 PTHR39490:SF8 ARRESTIN DOMAIN-CONTAINING PROTEIN D ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 21 HELRO|EnsemblGenome=HelroG184382|UniProtKB=T1FL35 T1FL35 20209534 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188428|UniProtKB=T1FPZ3 T1FPZ3 20210890 PTHR11256:SF48 BCL-2 RELATED BCL-2-RELATED OVARIAN KILLER PROTEIN protein binding#GO:0005515;binding#GO:0005488 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of cysteine-type endopeptidase activity involved in apoptotic process#GO:0043280;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;signal transduction#GO:0007165;positive regulation of cysteine-type endopeptidase activity#GO:2001056;regulation of protein metabolic process#GO:0051246;apoptotic mitochondrial changes#GO:0008637;regulation of cysteine-type endopeptidase activity#GO:2000116;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;positive regulation of proteolysis#GO:0045862;regulation of biological process#GO:0050789;activation of cysteine-type endopeptidase activity involved in apoptotic process#GO:0006919;DNA damage response#GO:0006974;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;apoptotic process#GO:0006915;cell death#GO:0008219;regulation of hydrolase activity#GO:0051336;mitochondrion organization#GO:0007005;intracellular signal transduction#GO:0035556;positive regulation of biological process#GO:0048518;positive regulation of peptidase activity#GO:0010952;signaling#GO:0023052;regulation of proteolysis#GO:0030162;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;programmed cell death#GO:0012501;cell communication#GO:0007154;cellular component organization#GO:0016043;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of hydrolase activity#GO:0051345;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;intrinsic apoptotic signaling pathway#GO:0097193;apoptotic signaling pathway#GO:0097190;response to stimulus#GO:0050896;positive regulation of protein metabolic process#GO:0051247;response to stress#GO:0006950;extrinsic apoptotic signaling pathway#GO:0097191;regulation of macromolecule metabolic process#GO:0060255;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;regulation of endopeptidase activity#GO:0052548;regulation of cysteine-type endopeptidase activity involved in apoptotic process#GO:0043281;regulation of peptidase activity#GO:0052547;release of cytochrome c from mitochondria#GO:0001836;cellular response to stress#GO:0033554;positive regulation of endopeptidase activity#GO:0010950;regulation of metabolic process#GO:0019222 bounding membrane of organelle#GO:0098588;envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial outer membrane#GO:0005741;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867 Apoptosis signaling pathway#P00006>Bok#P00261 HELRO|EnsemblGenome=HelroG179603|UniProtKB=T1FEX7 T1FEX7 20207376 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG67025|UniProtKB=T1FYV3 T1FYV3 20214001 PTHR43557:SF4 APOPTOSIS-INDUCING FACTOR 1 APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;flavin adenine dinucleotide binding#GO:0050660;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168;oxidoreductase activity, acting on NAD(P)H#GO:0016651;oxidoreductase activity#GO:0016491 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;mitochondrial respiratory chain complex assembly#GO:0033108;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;protein-containing complex assembly#GO:0065003;cell death#GO:0008219;programmed cell death#GO:0012501;cellular component organization#GO:0016043;mitochondrion organization#GO:0007005;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176 Apoptosis signaling pathway#P00006>AIF#P00286 HELRO|EnsemblGenome=HelroG176891|UniProtKB=T1FB09 T1FB09 20206008 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159084|UniProtKB=T1ENK4 T1ENK4 20198154 PTHR21676:SF6 PROTEIN STUM PROTEIN STUM HELRO|EnsemblGenome=HelroG108719|UniProtKB=T1EEL7 T1EEL7 20195019 PTHR20974:SF0 UPF0585 PROTEIN CG18661 UPF0585 PROTEIN CG18661 HELRO|EnsemblGenome=HelroG184688|UniProtKB=T1FLS0 T1FLS0 20209769 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG167246|UniProtKB=T1EZ62 T1EZ62 20201862 PTHR24012:SF897 RNA BINDING PROTEIN RNA-BINDING PROTEIN 42 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG185353|UniProtKB=T1FMQ1 T1FMQ1 20210100 PTHR45665:SF9 AQUAPORIN-8 AQUAPORIN-8 inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;channel activity#GO:0015267;water transmembrane transporter activity#GO:0005372 localization#GO:0051179;water transport#GO:0006833;establishment of localization#GO:0051234;fluid transport#GO:0042044;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG190584|UniProtKB=T1FS42 T1FS42 20211639 PTHR11157:SF17 FATTY ACID ACYL TRANSFERASE-RELATED ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 6 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;monocarboxylic acid biosynthetic process#GO:0072330;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;organic acid metabolic process#GO:0006082;membrane lipid biosynthetic process#GO:0046467;sphingolipid metabolic process#GO:0006665;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;fatty acid metabolic process#GO:0006631;membrane lipid metabolic process#GO:0006643;nitrogen compound metabolic process#GO:0006807;small molecule biosynthetic process#GO:0044283;cellular lipid metabolic process#GO:0044255;carboxylic acid metabolic process#GO:0019752;sphingolipid biosynthetic process#GO:0030148;fatty acid biosynthetic process#GO:0006633;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG191199|UniProtKB=T1FSQ7 T1FSQ7 20211854 PTHR13280:SF17 PHOSPHOFURIN ACIDIC CLUSTER SORTING PROTEIN KRUEPPEL TARGET AT 95D, ISOFORM A HELRO|EnsemblGenome=HelroG74935|UniProtKB=T1G1Y1 T1G1Y1 20215079 PTHR38537:SF8 JITTERBUG, ISOFORM N FILAMIN-A HELRO|EnsemblGenome=HelroG69215|UniProtKB=T1FZR0 T1FZR0 20214308 PTHR43655:SF2 ATP-DEPENDENT PROTEASE AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG160499|UniProtKB=T1EQB8 T1EQB8 20198768 PTHR15437:SF6 TRANSCRIPTION TERMINATION FACTOR, MITOCHONDRIAL TRANSCRIPTION TERMINATION FACTOR, MITOCHONDRIAL HELRO|EnsemblGenome=HelroG189332|UniProtKB=T1FQZ0 T1FQZ0 20211237 PTHR44535:SF1 PROTEIN CBG16200 SERINE_THREONINE-PROTEIN KINASE NEK9 HELRO|EnsemblGenome=HelroG186032|UniProtKB=T1FNK4 T1FNK4 20210401 PTHR11353:SF19 CHAPERONIN T-COMPLEX PROTEIN 1 SUBUNIT THETA protein binding#GO:0005515;unfolded protein binding#GO:0051082;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;chaperonin-containing T-complex#GO:0005832;protein folding chaperone complex#GO:0101031;intracellular anatomical structure#GO:0005622 chaperonin#PC00073 HELRO|EnsemblGenome=HelroG156238|UniProtKB=T1ELT2 T1ELT2 20197532 PTHR23050:SF518 CALCIUM BINDING PROTEIN AT16150P-RELATED cation binding#GO:0043169;small molecule binding#GO:0036094;molecular function regulator activity#GO:0098772;binding#GO:0005488;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;enzyme regulator activity#GO:0030234 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061 B cell activation#P00010>Calmodulin#P00375;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Calmodulin#P00755;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716;T cell activation#P00053>Calmodulin#P01305 HELRO|EnsemblGenome=HelroG70342|UniProtKB=T1G051 T1G051 20214449 PTHR46289:SF19 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG80086|UniProtKB=T1G3X5 T1G3X5 20215773 PTHR24637:SF388 COLLAGEN NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG95527|UniProtKB=T1G966 T1G966 20217613 PTHR19375:SF438 HEAT SHOCK PROTEIN 70KDA HEAT SHOCK 70 KDA PROTEIN 14 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;ribosome#GO:0005840;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 Hsp70 family chaperone#PC00027 HELRO|EnsemblGenome=HelroG150328|UniProtKB=T1EKF1 T1EKF1 20197051 PTHR22957:SF676 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 2B nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;activation of GTPase activity#GO:0090630;biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG183494|UniProtKB=T1FJR4 T1FJR4 20209063 PTHR21646:SF74 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 19 cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG66826|UniProtKB=T1FYR7 T1FYR7 20213965 PTHR23033:SF14 BETA1,3-GALACTOSYLTRANSFERASE GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED galactosyltransferase activity#GO:0008378;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG111042|UniProtKB=T1EF74 T1EF74 20195226 PTHR11759:SF1 40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11 40S RIBOSOMAL PROTEIN S14 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;small ribosomal subunit#GO:0015935;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG156361|UniProtKB=T1ELU1 T1ELU1 20197541 PTHR11761:SF8 50S/60S RIBOSOMAL PROTEIN L14/L23 LARGE RIBOSOMAL SUBUNIT PROTEIN UL14 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159;rRNA binding#GO:0019843 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG192807|UniProtKB=T1FUB5 T1FUB5 20212411 PTHR14952:SF21 ROPPORIN-1-LIKE PROTEIN IQ DOMAIN-CONTAINING PROTEIN E HELRO|EnsemblGenome=HelroG165510|UniProtKB=T1EWY1 T1EWY1 20201081 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG72173|UniProtKB=T1G0W7 T1G0W7 20214715 PTHR12910:SF2 NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2 NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12 response to stimulus#GO:0050896;response to stress#GO:0006950;response to oxidative stress#GO:0006979 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transporter complex#GO:1990351;oxidoreductase complex#GO:1990204;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;respirasome#GO:0070469;mitochondrial respiratory chain complex I#GO:0005747;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;mitochondrial respirasome#GO:0005746;transmembrane transporter complex#GO:1902495;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;respiratory chain complex I#GO:0045271;NADH dehydrogenase complex#GO:0030964;mitochondrial protein-containing complex#GO:0098798 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG156877|UniProtKB=T1EM24 T1EM24 20197624 PTHR48493:SF1 UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1 UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1 HELRO|EnsemblGenome=HelroG102065|UniProtKB=T1ED78 T1ED78 20194530 PTHR46550:SF1 F-BOX ONLY PROTEIN 3 F-BOX PROTEIN 3 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG103772|UniProtKB=T1EDH4 T1EDH4 20194626 PTHR14950:SF37 DICER-RELATED ENDORIBONUCLEASE DICER HELRO|EnsemblGenome=HelroG167561|UniProtKB=T1EZH7 T1EZH7 20201977 PTHR11414:SF21 CYSTATIN FAMILY MEMBER CYSTATIN 14A, TANDEM DUPLICATE 1-RELATED protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG158443|UniProtKB=T1EMS7 T1EMS7 20197877 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG136424|UniProtKB=T1EIE0 T1EIE0 20196340 PTHR23235:SF170 KRUEPPEL-LIKE TRANSCRIPTION FACTOR FI01014P-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG111895|UniProtKB=T1EFF4 T1EFF4 20195306 PTHR12072:SF4 CWF19, CELL CYCLE CONTROL PROTEIN CWF19-LIKE PROTEIN 1 enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;post-mRNA release spliceosomal complex#GO:0071014;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG169458|UniProtKB=T1F1Y8 T1F1Y8 20202838 PTHR22763:SF190 RING ZINC FINGER PROTEIN RING FINGER PROTEIN 24 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG109184|UniProtKB=T1EER1 T1EER1 20195063 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;heme binding#GO:0020037 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG191290|UniProtKB=T1FSU6 T1FSU6 20211893 PTHR24202:SF53 E3 UBIQUITIN-PROTEIN LIGASE MIB2 E3 UBIQUITIN-PROTEIN LIGASE MIB1 protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;transport#GO:0006810;endocytosis#GO:0006897;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;vesicle-mediated transport#GO:0016192;cell communication#GO:0007154;cellular process#GO:0009987;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;localization#GO:0051179;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;import into cell#GO:0098657;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;Notch signaling pathway#GO:0007219 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG97702|UniProtKB=T1G9I6 T1G9I6 20217733 PTHR23147:SF245 SERINE/ARGININE RICH SPLICING FACTOR CCHC-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;nuclear speck#GO:0016607;organelle#GO:0043226;nuclear body#GO:0016604;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG151243|UniProtKB=T1EKJ2 T1EKJ2 20197092 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG194466|UniProtKB=T1FW30 T1FW30 20213026 PTHR10694:SF33 LYSINE-SPECIFIC DEMETHYLASE LYSINE-SPECIFIC DEMETHYLASE 5 histone modifying activity#GO:0140993;demethylase activity#GO:0032451;catalytic activity, acting on a protein#GO:0140096;histone demethylase activity#GO:0032452;catalytic activity#GO:0003824 protein-DNA complex organization#GO:0071824;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;protein-containing complex organization#GO:0043933;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG162634|UniProtKB=T1ESY3 T1ESY3 20199683 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176502|UniProtKB=T1FAL3 T1FAL3 20205862 PTHR12558:SF13 CELL DIVISION CYCLE 16,23,27 CELL DIVISION CYCLE PROTEIN 27 HOMOLOG ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG175948|UniProtKB=T1F9Y2 T1F9Y2 20205631 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163202|UniProtKB=T1ETS6 T1ETS6 20199976 PTHR19372:SF7 SULFITE REDUCTASE SULFITE OXIDASE, MITOCHONDRIAL tetrapyrrole binding#GO:0046906;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;oxidoreductase activity#GO:0016491;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;heme binding#GO:0020037 cellular metabolic process#GO:0044237;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;metabolic process#GO:0008152 reductase#PC00198;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG93050|UniProtKB=T1G8S1 T1G8S1 20217468 PTHR24347:SF433 SERINE/THREONINE-PROTEIN KINASE CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE I-RELATED non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG90264|UniProtKB=T1G7N6 T1G7N6 20217083 PTHR43150:SF2 HYPERKINETIC, ISOFORM M HYPERKINETIC, ISOFORM M HELRO|EnsemblGenome=HelroG63243|UniProtKB=T1FXC8 T1FXC8 20213476 PTHR11360:SF284 MONOCARBOXYLATE TRANSPORTER EG:103B4.3 PROTEIN-RELATED transporter#PC00227 HELRO|EnsemblGenome=HelroG191555|UniProtKB=T1FT28 T1FT28 20211975 PTHR12027:SF102 WNT RELATED PROTEIN WNT molecular function activator activity#GO:0140677;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;protein binding#GO:0005515;cytokine activity#GO:0005125;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;neurogenesis#GO:0022008;developmental process#GO:0032502;multicellular organism development#GO:0007275;cell communication#GO:0007154;cell fate commitment#GO:0045165;cell-cell signaling by wnt#GO:0198738;nervous system development#GO:0007399;cellular process#GO:0009987;regulation of biological process#GO:0050789;system development#GO:0048731;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;cell-cell signaling#GO:0007267;signaling#GO:0023052;canonical Wnt signaling pathway#GO:0060070;Wnt signaling pathway#GO:0016055 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Cadherin signaling pathway#P00012>Wnt#P00474 HELRO|EnsemblGenome=HelroG193902|UniProtKB=T1FVG7 T1FVG7 20212813 PTHR11633:SF1 PLATELET-DERIVED GROWTH FACTOR LD28763P growth factor receptor binding#GO:0070851;protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of protein phosphorylation#GO:0001934;positive regulation of phosphorylation#GO:0042327;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;regulation of cell population proliferation#GO:0042127;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;positive regulation of phosphorus metabolic process#GO:0010562;positive regulation of cell population proliferation#GO:0008284;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of protein modification process#GO:0031401;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;regulation of primary metabolic process#GO:0080090;positive regulation of protein metabolic process#GO:0051247;positive regulation of metabolic process#GO:0009893;positive regulation of phosphate metabolic process#GO:0045937;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of protein phosphorylation#GO:0001932;biological regulation#GO:0065007;positive regulation of biological process#GO:0048518;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 intercellular signal molecule#PC00207;growth factor#PC00112 HELRO|EnsemblGenome=HelroG194608|UniProtKB=T1FW87 T1FW87 20213083 PTHR18866:SF33 CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED ligase#PC00142 Methylmalonyl pathway#P02755>Propionyl-CoA carboxylase#P03033 HELRO|EnsemblGenome=HelroG191370|UniProtKB=T1FSX5 T1FSX5 20211922 PTHR23189:SF102 RNA RECOGNITION MOTIF-CONTAINING FI21126P1-RELATED membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG87513|UniProtKB=T1G6R3 T1G6R3 20216760 PTHR24322:SF736 PKSB RETINOL DEHYDROGENASE 10 oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG188573|UniProtKB=T1FQ51 T1FQ51 20210948 PTHR24023:SF1095 COLLAGEN ALPHA EGF-LIKE DOMAIN-CONTAINING PROTEIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Integrin alpha#P00941;Integrin signalling pathway#P00034>Collagen#P00922 HELRO|EnsemblGenome=HelroG69428|UniProtKB=T1FZV3 T1FZV3 20214351 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG71107|UniProtKB=T1G0G7 T1G0G7 20214565 PTHR19305:SF14 SYNAPTOSOMAL ASSOCIATED PROTEIN SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED syntaxin binding#GO:0019905;molecular adaptor activity#GO:0060090;protein binding#GO:0005515;SNAP receptor activity#GO:0005484;binding#GO:0005488;SNARE binding#GO:0000149;protein-macromolecule adaptor activity#GO:0030674 vesicle fusion#GO:0006906;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;synaptic vesicle cycle#GO:0099504;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;protein-containing complex assembly#GO:0065003;endomembrane system organization#GO:0010256;regulation of biological process#GO:0050789;regulated exocytosis#GO:0045055;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;secretion#GO:0046903;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;signal release#GO:0023061;vesicle organization#GO:0016050;cell-cell signaling#GO:0007267;signaling#GO:0023052;synaptic vesicle exocytosis#GO:0016079;secretion by cell#GO:0032940;organelle fusion#GO:0048284;vesicle fusion to plasma membrane#GO:0099500;neurotransmitter secretion#GO:0007269;cellular component assembly#GO:0022607;trans-synaptic signaling#GO:0099537;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cell communication#GO:0007154;cellular process#GO:0009987;exocytic process#GO:0140029;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;signal release from synapse#GO:0099643;membrane fusion#GO:0061025;exocytosis#GO:0006887;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;export from cell#GO:0140352;vesicle-mediated transport in synapse#GO:0099003 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;SNARE complex#GO:0031201;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034 Synaptic vesicle trafficking#P05734>SNAP-25#P05778;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066;Opioid proenkephalin pathway#P05915>SNARE Complex#P05986;Thyrotropin-releasing hormone receptor signaling pathway#P04394>SNARE Complex#P04582;Dopamine receptor mediated signaling pathway#P05912>SNARE Complex#P05956;Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072;Beta3 adrenergic receptor signaling pathway#P04379>SNARE Complex#P04447;5HT4 type receptor mediated signaling pathway#P04376>SNARE Complex#P04428;Opioid prodynorphin pathway#P05916>SNARE Complex#P05996;Alpha adrenergic receptor signaling pathway#P00002>SNARE#P00074;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;5HT3 type receptor mediated signaling pathway#P04375>SNARE Complex#P04423;Ionotropic glutamate receptor pathway#P00037>SNARE Complex#P01013;Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049;Opioid proopiomelanocortin pathway#P05917>SNARE Complex#P06005;Cortocotropin releasing factor receptor signaling pathway#P04380>SNARE Complex#P04457;Beta1 adrenergic receptor signaling pathway#P04377>SNARE Complex#P04435;Oxytocin receptor mediated signaling pathway#P04391>SNARE Complex#P04532;Metabotropic glutamate receptor group III pathway#P00039>SNARE Complex#P01042;5HT2 type receptor mediated signaling pathway#P04374>SNARE Complex#P04415;5HT1 type receptor mediated signaling pathway#P04373>SNARE Complex#P04405;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;Beta2 adrenergic receptor signaling pathway#P04378>SNARE Complex#P04442 HELRO|EnsemblGenome=HelroG185227|UniProtKB=T1FMJ2 T1FMJ2 20210041 PTHR12226:SF2 MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN HELRO|EnsemblGenome=HelroG124583|UniProtKB=T1EH19 T1EH19 20195869 PTHR39074:SF1 AGAP007547-PA AGAP007547-PA HELRO|EnsemblGenome=HelroG166131|UniProtKB=T1EXT9 T1EXT9 20201389 PTHR21284:SF12 EG:80H7.2 PROTEIN EG:80H7.2 PROTEIN HELRO|EnsemblGenome=HelroG179156|UniProtKB=T1FE99 T1FE99 20207148 PTHR22748:SF6 AP ENDONUCLEASE DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE hydrolase activity, acting on ester bonds#GO:0016788;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;3'-5'-DNA exonuclease activity#GO:0008296;nuclease activity#GO:0004518;DNA exonuclease activity#GO:0004529;catalytic activity#GO:0003824;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097;phosphoric diester hydrolase activity#GO:0008081;exonuclease activity#GO:0004527;3'-5' exonuclease activity#GO:0008408;phosphoric ester hydrolase activity#GO:0042578 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;base-excision repair#GO:0006284;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 HELRO|EnsemblGenome=HelroG191469|UniProtKB=T1FT06 T1FT06 20211953 PTHR11567:SF211 ACID PHOSPHATASE-RELATED PROSTATIC ACID PHOSPHATASE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 cellular metabolic process#GO:0044237;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;dephosphorylation#GO:0016311;metabolic process#GO:0008152 metabolite interconversion enzyme#PC00262;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG110458|UniProtKB=T1EF23 T1EF23 20195175 PTHR11668:SF472 SERINE/THREONINE PROTEIN PHOSPHATASE SERINE_THREONINE-PROTEIN PHOSPHATASE PP1-BETA CATALYTIC SUBUNIT hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 Nicotine pharmacodynamics pathway#P06587>PPP1CA#P06602;Dopamine receptor mediated signaling pathway#P05912>Protein Phosphatase-1#P05969 HELRO|EnsemblGenome=HelroG184851|UniProtKB=T1FM30 T1FM30 20209879 PTHR24082:SF506 NUCLEAR HORMONE RECEPTOR NR LBD DOMAIN-CONTAINING PROTEIN C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG159928|UniProtKB=T1EPK5 T1EPK5 20198505 PTHR10151:SF114 ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE C27A7.3 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG185158|UniProtKB=T1FMG4 T1FMG4 20210013 PTHR10410:SF6 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED COP9 SIGNALOSOME COMPLEX SUBUNIT 5 hydrolase activity#GO:0016787;ubiquitin-like protein peptidase activity#GO:0019783;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein modification by small protein removal#GO:0070646;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;COP9 signalosome#GO:0008180;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223 PDGF signaling pathway#P00047>c-Jun#P01163 HELRO|EnsemblGenome=HelroG70323|UniProtKB=T1G047 T1G047 20214445 PTHR24241:SF59 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR ADIPOKINETIC HORMONE RECEPTOR, ISOFORM C signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;binding#GO:0005488;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888;amide binding#GO:0033218 response to organic substance#GO:0010033;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;response to hormone#GO:0009725;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GqPCR#P00730 HELRO|EnsemblGenome=HelroG83279|UniProtKB=T1G533 T1G533 20216181 PTHR20648:SF0 ELONGIN-C ELONGIN-C molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;transcription elongation factor complex#GO:0008023;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG178965|UniProtKB=T1FDZ5 T1FDZ5 20207044 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG189095|UniProtKB=T1FQM7 T1FQM7 20211124 PTHR13817:SF171 TITIN STRETCHIN-MLCK, ISOFORM U structural protein#PC00211 HELRO|EnsemblGenome=HelroG172075|UniProtKB=T1F501 T1F501 20203900 PTHR19818:SF139 ZINC FINGER PROTEIN ZIC AND GLI PAIR-RULE PROTEIN ODD-PAIRED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG75808|UniProtKB=T1G2A5 T1G2A5 20215203 PTHR13132:SF29 ALPHA- 1,6 -FUCOSYLTRANSFERASE ALPHA-(1,6)-FUCOSYLTRANSFERASE transferase activity#GO:0016740;fucosyltransferase activity#GO:0008417;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein glycosylation#GO:0006486;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;protein metabolic process#GO:0019538;glycosylation#GO:0070085;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 glycosyltransferase#PC00111 Notch signaling pathway#P00045>Neurotic#P01115 HELRO|EnsemblGenome=HelroG168178|UniProtKB=T1F096 T1F096 20202246 PTHR47174:SF3 BRIDGING INTEGRATOR 3 BRIDGING INTEGRATOR 3 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG105066|UniProtKB=T1EDQ3 T1EDQ3 20194705 PTHR13799:SF13 NGG1 INTERACTING FACTOR 3 NIF3-LIKE PROTEIN 1 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG90681|UniProtKB=T1G7U3 T1G7U3 20217140 PTHR13554:SF10 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5-RELATED 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 protease#PC00190 HELRO|EnsemblGenome=HelroG162200|UniProtKB=T1ESC5 T1ESC5 20199475 PTHR24230:SF75 G-PROTEIN COUPLED RECEPTOR RELAXIN FAMILY PEPTIDE RECEPTOR 3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;neuropeptide signaling pathway#GO:0007218;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG175331|UniProtKB=T1F954 T1F954 20205353 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162810|UniProtKB=T1ET72 T1ET72 20199772 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG91647|UniProtKB=T1G871 T1G871 20217268 PTHR12626:SF0 PROGRAMMED CELL DEATH 4 PROGRAMMED CELL DEATH PROTEIN 4 translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG160604|UniProtKB=T1EQH3 T1EQH3 20198823 PTHR45628:SF1 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1 calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated calcium channel activity#GO:0005245;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;calcium ion transport#GO:0006816;localization#GO:0051179;calcium ion import#GO:0070509;import across plasma membrane#GO:0098739;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;calcium ion transmembrane import into cytosol#GO:0097553;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657 voltage-gated calcium channel complex#GO:0005891;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;calcium channel complex#GO:0034704;membrane#GO:0016020;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 Beta2 adrenergic receptor signaling pathway#P04378>Ca2+ channel#P04445;Beta1 adrenergic receptor signaling pathway#P04377>Ca2+ channel#P04438;Alzheimer disease-amyloid secretase pathway#P00003>L-type calcium channels#P00082;Oxytocin receptor mediated signaling pathway#P04391>Ca2+ channel#P04535;5HT2 type receptor mediated signaling pathway#P04374>Ca2+ channel#P04411;Nicotinic acetylcholine receptor signaling pathway#P00044>Ca2+ channel#P01096 HELRO|EnsemblGenome=HelroG194199|UniProtKB=T1FVS6 T1FVS6 20212922 PTHR24349:SF527 SERINE/THREONINE-PROTEIN KINASE LD17393P transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein serine/threonine kinase activity#GO:0004674;protein binding#GO:0005515;calmodulin binding#GO:0005516;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG133970|UniProtKB=T1EI30 T1EI30 20196230 PTHR20948:SF2 TRANSMEMBRANE PROTEIN 164 TRANSMEMBRANE PROTEIN 164 HELRO|EnsemblGenome=HelroG157214|UniProtKB=T1EM83 T1EM83 20197683 PTHR10759:SF0 60S RIBOSOMAL PROTEIN L34 60S RIBOSOMAL PROTEIN L34 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG112795|UniProtKB=T1EFM2 T1EFM2 20195374 PTHR11699:SF228 ALDEHYDE DEHYDROGENASE-RELATED 4-TRIMETHYLAMINOBUTYRALDEHYDE DEHYDROGENASE oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 dehydrogenase#PC00092;oxidoreductase#PC00176 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HELRO|EnsemblGenome=HelroG68096|UniProtKB=T1FZA2 T1FZA2 20214150 PTHR18884:SF130 SEPTIN SEPTIN GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 cell division#GO:0051301;cellular localization#GO:0051641;macromolecule localization#GO:0033036;cell cycle process#GO:0022402;regulation of secretion by cell#GO:1903530;regulation of localization#GO:0032879;cellular process#GO:0009987;regulation of vesicle-mediated transport#GO:0060627;protein localization#GO:0008104;localization#GO:0051179;regulation of biological process#GO:0050789;regulation of transport#GO:0051049;cellular macromolecule localization#GO:0070727;regulation of cellular process#GO:0050794;regulation of secretion#GO:0051046;biological regulation#GO:0065007;cytoskeleton-dependent cytokinesis#GO:0061640;cell cycle#GO:0007049;cytokinesis#GO:0000910;regulation of exocytosis#GO:0017157 presynapse#GO:0098793;synapse#GO:0045202;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;cell junction#GO:0030054;cellular anatomical entity#GO:0110165;cell cortex#GO:0005938;cell periphery#GO:0071944;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;transport vesicle#GO:0030133;cell division site#GO:0032153;cytoskeleton#GO:0005856;secretory vesicle#GO:0099503 cytoskeletal protein#PC00085 Parkinson disease#P00049>CDCrel-1#P01226 HELRO|EnsemblGenome=HelroG87443|UniProtKB=T1G6Q1 T1G6Q1 20216748 PTHR42799:SF2 MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;response to stress#GO:0006950;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;cellular response to oxidative stress#GO:0034599;response to oxidative stress#GO:0006979;cellular response to stress#GO:0033554;cellular process#GO:0009987 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 reductase#PC00198;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG75040|UniProtKB=T1G1Z7 T1G1Z7 20215095 PTHR23085:SF16 GH28348P GH28348P intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG67090|UniProtKB=T1FYW1 T1FYW1 20214009 PTHR24329:SF543 HOMEOBOX PROTEIN ARISTALESS FI01017P-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG84860|UniProtKB=T1G5P7 T1G5P7 20216394 PTHR22957:SF212 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN RELATED TO THE N TERMINUS OF TRE ONCOGENE, ISOFORM A nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;activation of GTPase activity#GO:0090630;biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG132567|UniProtKB=T1EHY9 T1EHY9 20196189 PTHR24241:SF161 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;binding#GO:0005488;amide binding#GO:0033218;peptide binding#GO:0042277;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled peptide receptor activity#GO:0008528;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;cellular response to endogenous stimulus#GO:0071495;cellular response to chemical stimulus#GO:0070887;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to endogenous stimulus#GO:0009719;response to hormone#GO:0009725;cellular response to hormone stimulus#GO:0032870;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG72380|UniProtKB=T1G0Z2 T1G0Z2 20214740 PTHR20961:SF148 GLYCOSYLTRANSFERASE EGF DOMAIN-SPECIFIC O-LINKED N-ACETYLGLUCOSAMINE TRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG85565|UniProtKB=T1G5Z5 T1G5Z5 20216492 PTHR10328:SF3 PROTEIN MAX MYC-ASSOCIATED FACTOR X PROTEIN MAX transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 basic helix-loop-helix transcription factor#PC00055 Oxidative stress response#P00046>Max#P01133 HELRO|EnsemblGenome=HelroG184609|UniProtKB=T1FLK9 T1FLK9 20209708 PTHR33332:SF48 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191180|UniProtKB=T1FSP9 T1FSP9 20211846 PTHR10241:SF29 LETHAL 2 GIANT LARVAE PROTEIN LETHAL(2) GIANT LARVAE PROTEIN nucleoside-triphosphatase regulator activity#GO:0060589;cytoskeletal protein binding#GO:0008092;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;myosin binding#GO:0017022;GTPase activator activity#GO:0005096;molecular function regulator activity#GO:0098772;binding#GO:0005488;syntaxin binding#GO:0019905;protein binding#GO:0005515;enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;SNARE binding#GO:0000149 establishment or maintenance of cell polarity#GO:0007163;cellular localization#GO:0051641;organelle localization#GO:0051640;post-Golgi vesicle-mediated transport#GO:0006892;transport#GO:0006810;establishment of spindle orientation#GO:0051294;regulation of signaling#GO:0023051;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;regulation of Notch signaling pathway#GO:0008593;Golgi to plasma membrane transport#GO:0006893;regulation of biological process#GO:0050789;establishment of cell polarity#GO:0030010;actin filament-based process#GO:0030029;establishment of localization#GO:0051234;secretion#GO:0046903;regulation of signal transduction#GO:0009966;cytoskeleton organization#GO:0007010;establishment of organelle localization#GO:0051656;spindle localization#GO:0051653;secretion by cell#GO:0032940;localization within membrane#GO:0051668;regulation of cell communication#GO:0010646;vesicle-mediated transport to the plasma membrane#GO:0098876;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;establishment of spindle localization#GO:0051293;localization#GO:0051179;regulation of response to stimulus#GO:0048583;cellular component organization or biogenesis#GO:0071840;exocytosis#GO:0006887;microtubule-based process#GO:0007017;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;cortical cytoskeleton organization#GO:0030865;biological regulation#GO:0065007;cell cycle#GO:0007049;establishment of localization in cell#GO:0051649;actin cytoskeleton organization#GO:0030036;export from cell#GO:0140352;cortical actin cytoskeleton organization#GO:0030866 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;cytoskeleton#GO:0005856;cortical actin cytoskeleton#GO:0030864;cellular anatomical entity#GO:0110165;cell cortex#GO:0005938;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG82979|UniProtKB=T1G4Y8 T1G4Y8 20216136 PTHR48112:SF22 HIGH MOBILITY GROUP PROTEIN DSP1 MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG74817|UniProtKB=T1G1W1 T1G1W1 20215059 PTHR10192:SF5 MOLYBDOPTERIN BIOSYNTHESIS PROTEIN GEPHYRIN transferase activity#GO:0016740;catalytic activity#GO:0003824 heterocycle metabolic process#GO:0046483;macromolecule metabolic process#GO:0043170;organophosphate biosynthetic process#GO:0090407;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organophosphate metabolic process#GO:0019637;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG142725|UniProtKB=T1EJ71 T1EJ71 20196621 PTHR24416:SF489 TYROSINE-PROTEIN KINASE RECEPTOR PROTEIN KINASE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG183795|UniProtKB=T1FK73 T1FK73 20209222 PTHR10845:SF192 REGULATOR OF G PROTEIN SIGNALING DOUBLE HIT, ISOFORM B G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731 HELRO|EnsemblGenome=HelroG85076|UniProtKB=T1G5S5 T1G5S5 20216422 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162447|UniProtKB=T1ESN9 T1ESN9 20199589 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163981|UniProtKB=T1EUQ0 T1EUQ0 20200300 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189632|UniProtKB=T1FR79 T1FR79 20211326 PTHR45960:SF2 GRB2-ASSOCIATED-BINDING PROTEIN PROTEIN DAUGHTER OF SEVENLESS scaffold/adaptor protein#PC00226 EGF receptor signaling pathway#P00018>Gab#P00563 HELRO|EnsemblGenome=HelroG123067|UniProtKB=T1EGW8 T1EGW8 20195818 PTHR11785:SF516 AMINO ACID TRANSPORTER AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN L-amino acid transmembrane transporter activity#GO:0015179;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;amino acid transport#GO:0006865;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;nitrogen compound transport#GO:0071705;organic acid transmembrane transport#GO:1903825;carboxylic acid transport#GO:0046942;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039 transporter#PC00227 HELRO|EnsemblGenome=HelroG173738|UniProtKB=T1F765 T1F765 20204664 PTHR21531:SF0 LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED PROTEIN LTV1 HOMOLOG cellular component biogenesis#GO:0044085;ribosomal subunit export from nucleus#GO:0000054;cellular localization#GO:0051641;organelle localization#GO:0051640;transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;ribonucleoprotein complex biogenesis#GO:0022613;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;ribosome biogenesis#GO:0042254;nuclear transport#GO:0051169;establishment of organelle localization#GO:0051656;ribosomal small subunit biogenesis#GO:0042274;protein-containing complex localization#GO:0031503 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;preribosome, small subunit precursor#GO:0030688;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;preribosome#GO:0030684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG144094|UniProtKB=T1EJD6 T1EJD6 20196686 PTHR45695:SF15 LEUCOKININ RECEPTOR-RELATED OPSIN RH2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Rhodopsin#P00747 HELRO|EnsemblGenome=HelroG63446|UniProtKB=T1FXF9 T1FXF9 20213507 PTHR19269:SF45 TROPOMYOSIN TROPOMYOSIN-1, ISOFORMS 33_34 cytoskeletal protein#PC00085;actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG161814|UniProtKB=T1ERY0 T1ERY0 20199330 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG76642|UniProtKB=T1G2M4 T1G2M4 20215322 PTHR10615:SF161 HISTONE ACETYLTRANSFERASE HISTONE ACETYLTRANSFERASE KAT7 histone modifying activity#GO:0140993;acyltransferase activity#GO:0016746;peptide N-acetyltransferase activity#GO:0034212;binding#GO:0005488;catalytic activity#GO:0003824;protein-macromolecule adaptor activity#GO:0030674;N-acyltransferase activity#GO:0016410;molecular adaptor activity#GO:0060090;histone acetyltransferase activity#GO:0004402;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;N-acetyltransferase activity#GO:0008080;transferase activity#GO:0016740;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;peptide-lysine-N-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;chromatin binding#GO:0003682;protein-containing complex binding#GO:0044877;catalytic activity, acting on a protein#GO:0140096 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 Alzheimer disease-presenilin pathway#P00004>Tip60#P00137 HELRO|EnsemblGenome=HelroG115658|UniProtKB=T1EG98 T1EG98 20195600 PTHR42886:SF29 RE40534P-RELATED PUMMELIG, ISOFORM A HELRO|EnsemblGenome=HelroG98642|UniProtKB=T1G9P0 T1G9P0 20217786 PTHR48069:SF3 DIHYDROFOLATE REDUCTASE DIHYDROFOLATE REDUCTASE nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491 cellular aromatic compound metabolic process#GO:0006725;oxoacid metabolic process#GO:0043436;heterocycle metabolic process#GO:0046483;dicarboxylic acid metabolic process#GO:0043648;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;folic acid-containing compound metabolic process#GO:0006760;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;heterocycle biosynthetic process#GO:0018130;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;cellular modified amino acid metabolic process#GO:0006575;aromatic compound biosynthetic process#GO:0019438;carboxylic acid metabolic process#GO:0019752;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 reductase#PC00198;oxidoreductase#PC00176 Formyltetrahydrofolate biosynthesis#P02743>Dihydrofolate reductase#P02957;Tetrahydrofolate biosynthesis#P02742>Dihydrofolate reductase#P02948;Tetrahydrofolate biosynthesis#P02742>Dihydrofolate synthase#P02943 HELRO|EnsemblGenome=HelroG126823|UniProtKB=T1EHB2 T1EHB2 20195962 PTHR13080:SF20 ATP SYNTHASE F CHAIN, MITOCHONDRIAL-RELATED ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL-RELATED monoatomic cation channel activity#GO:0005261;ligase activity#GO:0016874;inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;catalytic activity#GO:0003824;proton transmembrane transporter activity#GO:0015078;proton channel activity#GO:0015252;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;inorganic cation transmembrane transporter activity#GO:0022890;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 cellular aromatic compound metabolic process#GO:0006725;ribonucleoside triphosphate metabolic process#GO:0009199;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative metabolic process#GO:1901135;ATP biosynthetic process#GO:0006754;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;energy derivation by oxidation of organic compounds#GO:0015980;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;purine nucleoside triphosphate biosynthetic process#GO:0009145;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;heterocycle metabolic process#GO:0046483;purine ribonucleoside triphosphate metabolic process#GO:0009205;generation of precursor metabolites and energy#GO:0006091;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;ribonucleoside triphosphate biosynthetic process#GO:0009201;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;proton motive force-driven ATP synthesis#GO:0015986;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;oxidative phosphorylation#GO:0006119;aromatic compound biosynthetic process#GO:0019438;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;purine nucleoside triphosphate metabolic process#GO:0009144;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;ATPase complex#GO:1904949;organelle inner membrane#GO:0019866;mitochondrial proton-transporting ATP synthase complex#GO:0005753;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;proton-transporting two-sector ATPase complex#GO:0016469;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;proton-transporting ATP synthase complex#GO:0045259;mitochondrial protein-containing complex#GO:0098798 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG158637|UniProtKB=T1EN22 T1EN22 20197972 PTHR36191:SF1 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG94851|UniProtKB=T1G935 T1G935 20217582 PTHR13710:SF108 DNA HELICASE RECQ FAMILY MEMBER ATP-DEPENDENT DNA HELICASE Q4 ATP-dependent activity, acting on DNA#GO:0008094;3'-5' DNA helicase activity#GO:0043138;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;double-strand break repair#GO:0006302;nucleobase-containing compound metabolic process#GO:0006139;DNA geometric change#GO:0032392;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;recombinational repair#GO:0000725;DNA duplex unwinding#GO:0032508;DNA-templated DNA replication#GO:0006261;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;DNA unwinding involved in DNA replication#GO:0006268;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;double-strand break repair via homologous recombination#GO:0000724;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;DNA conformation change#GO:0071103;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;organelle organization#GO:0006996;chromosome organization#GO:0051276;cellular response to stress#GO:0033554;DNA replication#GO:0006260;DNA metabolic process#GO:0006259 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA helicase#PC00011;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG188294|UniProtKB=T1FPU3 T1FPU3 20210840 PTHR24346:SF82 MAP/MICROTUBULE AFFINITY-REGULATING KINASE KP78A-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG166349|UniProtKB=T1EY17 T1EY17 20201467 PTHR10693:SF20 RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN AT27578P nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;cytosol#GO:0005829;protein-containing complex#GO:0032991;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG68509|UniProtKB=T1FZG1 T1FZG1 20214209 PTHR43895:SF32 CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED SERINE_THREONINE-PROTEIN KINASE CHK1 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG164050|UniProtKB=T1EUU0 T1EUU0 20200340 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG108446|UniProtKB=T1EEI9 T1EEI9 20194991 PTHR13693:SF2 CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE SERINE PALMITOYLTRANSFERASE 1 palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824 organic hydroxy compound metabolic process#GO:1901615;lipid metabolic process#GO:0006629;alcohol biosynthetic process#GO:0046165;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic hydroxy compound biosynthetic process#GO:1901617;alcohol metabolic process#GO:0006066;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;membrane lipid biosynthetic process#GO:0046467;sphingolipid metabolic process#GO:0006665;primary metabolic process#GO:0044238;ceramide metabolic process#GO:0006672;amide biosynthetic process#GO:0043604;membrane lipid metabolic process#GO:0006643;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;ceramide biosynthetic process#GO:0046513;small molecule biosynthetic process#GO:0044283;cellular lipid metabolic process#GO:0044255;amide metabolic process#GO:0043603;sphingolipid biosynthetic process#GO:0030148;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transaminase#PC00216;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG165236|UniProtKB=T1EWH4 T1EWH4 20200924 PTHR42999:SF2 ANTIBIOTIC RESISTANCE PROTEIN MCBG SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG69587|UniProtKB=T1FZW8 T1FZW8 20214366 PTHR23407:SF1 ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE 5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;folic acid-containing compound metabolic process#GO:0006760;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular modified amino acid metabolic process#GO:0006575;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ligase#PC00142;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG151206|UniProtKB=T1EKI7 T1EKI7 20197087 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG194873|UniProtKB=T1FWI4 T1FWI4 20213179 PTHR22692:SF33 MYOSIN VII, XV MYOSIN actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG192296|UniProtKB=T1FTT0 T1FTT0 20212227 PTHR14596:SF77 ZINC FINGER PROTEIN TRANSCRIPTIONAL REGULATOR MNL1 cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to nutrient levels#GO:0031667;response to extracellular stimulus#GO:0009991;response to stress#GO:0006950;response to starvation#GO:0042594 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG168710|UniProtKB=T1F0V9 T1F0V9 20202459 PTHR22419:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 172 COILED-COIL DOMAIN-CONTAINING PROTEIN 172 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG166309|UniProtKB=T1EY02 T1EY02 20201452 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER FI01427P membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG177838|UniProtKB=T1FCC6 T1FCC6 20206475 PTHR23202:SF119 WASP INTERACTING PROTEIN-RELATED TWENTY-FOUR, ISOFORM B actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG179740|UniProtKB=T1FF37 T1FF37 20207436 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG180351|UniProtKB=T1FFT0 T1FFT0 20207679 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193701|UniProtKB=T1FVA0 T1FVA0 20212746 PTHR11036:SF127 SEMAPHORIN SEMAPHORIN-1A molecular function activator activity#GO:0140677;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;protein binding#GO:0005515;signaling receptor binding#GO:0005102 cellular developmental process#GO:0048869;regulation of cell motility#GO:2000145;regulation of locomotion#GO:0040012;stem cell development#GO:0048864;animal organ development#GO:0048513;neural crest cell development#GO:0014032;developmental process#GO:0032502;positive regulation of locomotion#GO:0040017;ameboidal-type cell migration#GO:0001667;cell motility#GO:0048870;cellular process#GO:0009987;tissue development#GO:0009888;mesenchymal cell differentiation#GO:0048762;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;cell development#GO:0048468;cell differentiation#GO:0030154;regulation of cell migration#GO:0030334;positive regulation of cell migration#GO:0030335;neural crest cell differentiation#GO:0014033;regulation of cellular process#GO:0050794;mesenchyme development#GO:0060485;anatomical structure development#GO:0048856;positive regulation of cell motility#GO:2000147;biological regulation#GO:0065007;stem cell differentiation#GO:0048863;neural crest cell migration#GO:0001755;cell migration#GO:0016477;positive regulation of biological process#GO:0048518 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 membrane-bound signaling molecule#PC00152;intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG186138|UniProtKB=T1FNP9 T1FNP9 20210446 PTHR43028:SF5 3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1 3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1 hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG188603|UniProtKB=T1FQ61 T1FQ61 20210958 PTHR13440:SF7 BLOC-1 RELATED COMPLEX SUBUNIT 6 BLOC-1 RELATED COMPLEX SUBUNIT 6 lysosome localization#GO:0032418;localization#GO:0051179;organelle localization#GO:0051640 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG68430|UniProtKB=T1FZE6 T1FZE6 20214194 PTHR10177:SF527 CYCLINS CYCLIN D, ISOFORM D protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234 regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;mitotic cell cycle phase transition#GO:0044772;regulation of nitrogen compound metabolic process#GO:0051171;cell cycle G1/S phase transition#GO:0044843;cell cycle process#GO:0022402;positive regulation of cell cycle#GO:0045787;positive regulation of cell cycle G1/S phase transition#GO:1902808;regulation of catalytic activity#GO:0050790;mitotic cell cycle process#GO:1903047;G1/S transition of mitotic cell cycle#GO:0000082;regulation of phosphorus metabolic process#GO:0051174;regulation of biological process#GO:0050789;mitotic cell cycle#GO:0000278;regulation of molecular function#GO:0065009;positive regulation of cell cycle process#GO:0090068;positive regulation of mitotic cell cycle#GO:0045931;regulation of protein serine/threonine kinase activity#GO:0071900;regulation of G1/S transition of mitotic cell cycle#GO:2000045;positive regulation of biological process#GO:0048518;regulation of cyclin-dependent protein serine/threonine kinase activity#GO:0000079;regulation of kinase activity#GO:0043549;regulation of protein kinase activity#GO:0045859;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of cell cycle phase transition#GO:1901987;cellular process#GO:0009987;cell cycle phase transition#GO:0044770;regulation of cell cycle process#GO:0010564;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule metabolic process#GO:0060255;regulation of protein phosphorylation#GO:0001932;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of phosphorylation#GO:0042325;regulation of mitotic cell cycle#GO:0007346;regulation of transferase activity#GO:0051338;regulation of cell cycle G1/S phase transition#GO:1902806;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 microtubule organizing center#GO:0005815;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;centrosome#GO:0005813;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856 kinase activator#PC00138 Wnt signaling pathway#P00057>Wnt Target Genes#G01558;Cell cycle#P00013>Cyclin D#P00484 HELRO|EnsemblGenome=HelroG175277|UniProtKB=T1F934 T1F934 20205333 PTHR42264:SF6 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE PROTEIN HELRO|EnsemblGenome=HelroG178275|UniProtKB=T1FD08 T1FD08 20206707 PTHR23351:SF24 FOS TRANSCRIPTION FACTOR-RELATED ACTIVATING TRANSCRIPTION FACTOR 3-RELATED DNA-binding transcription factor#PC00218;basic leucine zipper transcription factor#PC00056 HELRO|EnsemblGenome=HelroG194781|UniProtKB=T1FWE5 T1FWE5 20213140 PTHR10782:SF4 ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN TONALLI, ISOFORM E transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;SUMO transferase activity#GO:0019789;SUMO ligase activity#GO:0061665;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;protein sumoylation#GO:0016925;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG82651|UniProtKB=T1G4U8 T1G4U8 20216096 PTHR46010:SF1 PROTEIN IWS1 HOMOLOG PROTEIN IWS1 HOMOLOG poly(A)+ mRNA export from nucleus#GO:0016973;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;mRNA transport#GO:0051028;RNA localization#GO:0006403;localization#GO:0051179;organic substance transport#GO:0071702;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG161325|UniProtKB=T1ERC4 T1ERC4 20199124 PTHR11388:SF142 ORGANIC ANION TRANSPORTER SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 5A1 secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;organic substance transport#GO:0071702;establishment of localization#GO:0051234;organic anion transport#GO:0015711;transport#GO:0006810 basal plasma membrane#GO:0009925;basolateral plasma membrane#GO:0016323;plasma membrane region#GO:0098590;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;basal part of cell#GO:0045178;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG194870|UniProtKB=T1FWI2 T1FWI2 20213177 PTHR12826:SF13 RIBONUCLEASE Y RNA-BINDING PROTEIN PNO1 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG168508|UniProtKB=T1F0N2 T1F0N2 20202382 PTHR45665:SF9 AQUAPORIN-8 AQUAPORIN-8 inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;channel activity#GO:0015267;water transmembrane transporter activity#GO:0005372 localization#GO:0051179;water transport#GO:0006833;establishment of localization#GO:0051234;fluid transport#GO:0042044;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG88175|UniProtKB=T1G6Z4 T1G6Z4 20216841 PTHR11360:SF260 MONOCARBOXYLATE TRANSPORTER MFS DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;monocarboxylic acid transmembrane transporter activity#GO:0008028;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;monocarboxylic acid transport#GO:0015718;establishment of localization#GO:0051234;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942 transporter#PC00227 HELRO|EnsemblGenome=HelroG189443|UniProtKB=T1FR24 T1FR24 20211271 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG191505|UniProtKB=T1FT19 T1FT19 20211966 PTHR13064:SF6 TRANSMEMBRANE PROTEIN 9 FAMILY MEMBER TRANSMEMBRANE PROTEIN 9 HELRO|EnsemblGenome=HelroG184825|UniProtKB=T1FM20 T1FM20 20209869 PTHR23073:SF7 26S PROTEASOME REGULATORY SUBUNIT 26S PROTEASOME REGULATORY SUBUNIT 6A ATP-dependent activity#GO:0140657 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 peptidase complex#GO:1905368;protein-containing complex#GO:0032991;proteasome accessory complex#GO:0022624;proteasome regulatory particle#GO:0005838;catalytic complex#GO:1902494;proteasome complex#GO:0000502;endopeptidase complex#GO:1905369;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 protease#PC00190;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG184988|UniProtKB=T1FM84 T1FM84 20209933 PTHR10678:SF3 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2 COP9 SIGNALOSOME COMPLEX SUBUNIT 2 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein modification by small protein removal#GO:0070646;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;COP9 signalosome#GO:0008180;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG188401|UniProtKB=T1FPY4 T1FPY4 20210881 PTHR10334:SF590 CYSTEINE-RICH SECRETORY PROTEIN-RELATED SCP DOMAIN-CONTAINING PROTEIN extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG65487|UniProtKB=T1FY85 T1FY85 20213783 PTHR13040:SF2 AUTOPHAGY PROTEIN 5 AUTOPHAGY PROTEIN 5 ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824 microautophagy#GO:0016237;cellular component biogenesis#GO:0044085;macroautophagy#GO:0016236;macromolecule modification#GO:0043412;protein modification process#GO:0036211;autophagy of mitochondrion#GO:0000422;response to extracellular stimulus#GO:0009991;biosynthetic process#GO:0009058;post-translational protein modification#GO:0043687;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;cellular component disassembly#GO:0022411;cellular response to starvation#GO:0009267;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;mitochondrion organization#GO:0007005;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;cellular response to extracellular stimulus#GO:0031668;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;cellular response to stimulus#GO:0051716;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;cellular component organization#GO:0016043;response to nutrient levels#GO:0031667;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organelle disassembly#GO:1903008;lipoprotein biosynthetic process#GO:0042158;primary metabolic process#GO:0044238;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to stress#GO:0006950;organelle organization#GO:0006996;cellular response to nutrient levels#GO:0031669;response to starvation#GO:0042594;cellular response to external stimulus#GO:0071496;autophagosome assembly#GO:0000045;lipoprotein metabolic process#GO:0042157;cellular response to stress#GO:0033554;piecemeal microautophagy of the nucleus#GO:0034727;autophagy#GO:0006914 intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;vacuole#GO:0005773;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle membrane contact site#GO:0044232;membrane#GO:0016020;intracellular organelle#GO:0043229;autophagosome#GO:0005776;mitochondria-associated endoplasmic reticulum membrane#GO:0044233;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;phagophore assembly site#GO:0000407;membrane-bounded organelle#GO:0043227 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG164249|UniProtKB=T1EV58 T1EV58 20200458 PTHR20899:SF1 PIERCE HOMOLOG PIERCER OF MICROTUBULE WALL 1 PROTEIN HELRO|EnsemblGenome=HelroG112981|UniProtKB=T1EFP1 T1EFP1 20195393 PTHR14781:SF0 INTRAFLAGELLAR TRANSPORT PROTEIN 56 INTRAFLAGELLAR TRANSPORT PROTEIN 56 protein-containing complex binding#GO:0044877;binding#GO:0005488 cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;cilium assembly#GO:0060271;cell projection organization#GO:0030030;transport#GO:0006810;microtubule-based movement#GO:0007018;cellular component organization#GO:0016043;intraciliary transport involved in cilium assembly#GO:0035735;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;transport along microtubule#GO:0010970;cell projection assembly#GO:0030031;intraciliary transport#GO:0042073;localization#GO:0051179;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based transport#GO:0099111;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;organelle organization#GO:0006996;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;plasma membrane bounded cell projection assembly#GO:0120031;protein-containing complex localization#GO:0031503 microtubule organizing center#GO:0005815;ciliary base#GO:0097546;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;intraciliary transport particle B#GO:0030992;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929;intraciliary transport particle#GO:0030990 HELRO|EnsemblGenome=HelroG178118|UniProtKB=T1FCR8 T1FCR8 20206617 PTHR22802:SF463 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG121284|UniProtKB=T1EGR3 T1EGR3 20195763 PTHR13808:SF1 CBP/P300-RELATED HISTONE ACETYLTRANSFERASE histone modifying activity#GO:0140993;nucleic acid binding#GO:0003676;acyltransferase activity#GO:0016746;peptide N-acetyltransferase activity#GO:0034212;binding#GO:0005488;catalytic activity#GO:0003824;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;N-acyltransferase activity#GO:0016410;histone acetyltransferase activity#GO:0004402;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;molecular adaptor activity#GO:0060090;N-acetyltransferase activity#GO:0008080;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;chromatin DNA binding#GO:0031490;transferase activity#GO:0016740;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;protein-containing complex binding#GO:0044877;catalytic activity, acting on a protein#GO:0140096 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of RNA metabolic process#GO:0051254;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;chromatin#GO:0000785;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;chromosome#GO:0005694 histone modifying enzyme#PC00261 DPP signaling pathway#P06213>NEJ#P06284;TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282;SCW signaling pathway#P06216>NEJ#P06328;GBB signaling pathway#P06214>NEJ#P06295;BMP/activin signaling pathway-drosophila#P06211>NEJ#P06246;p53 pathway#P00059>CBP#P04623;Wnt signaling pathway#P00057>CBP#P01448;Transcription regulation by bZIP transcription factor#P00055>CBP/P300#P01387;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CREB#P00713;DPP-SCW signaling pathway#P06212>NEJ#P06260;Huntington disease#P00029>CBP#P00777 HELRO|EnsemblGenome=HelroG156213|UniProtKB=T1ELS9 T1ELS9 20197529 PTHR45677:SF10 GLUTAMATE DECARBOXYLASE-RELATED GLUTAMATE DECARBOXYLASE lyase activity#GO:0016829;carboxy-lyase activity#GO:0016831;carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;amino acid biosynthetic process#GO:0008652;small molecule biosynthetic process#GO:0044283;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 decarboxylase#PC00089 Gamma-aminobutyric acid synthesis#P04384>Glutamate decarboxylase#P04482 HELRO|EnsemblGenome=HelroG115024|UniProtKB=T1EG59 T1EG59 20195561 PTHR11679:SF2 VESICLE PROTEIN SORTING-ASSOCIATED SEC1 FAMILY DOMAIN-CONTAINING PROTEIN 1 syntaxin binding#GO:0019905;protein binding#GO:0005515;binding#GO:0005488;SNARE binding#GO:0000149 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG186278|UniProtKB=T1FNW7 T1FNW7 20210514 PTHR11909:SF20 CASEIN KINASE-RELATED CASEIN KINASE I ISOFORM ALPHA transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Hedgehog signaling pathway#P00025>Casein kinase I#P00681;Parkinson disease#P00049>Casein kinase I#P01242 HELRO|EnsemblGenome=HelroG104083|UniProtKB=T1EDJ5 T1EDJ5 20194647 PTHR24020:SF84 COLLAGEN ALPHA VWFA DOMAIN-CONTAINING PROTEIN extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG73705|UniProtKB=T1G1H5 T1G1H5 20214923 PTHR46359:SF2 GEO07743P1 GEO07743P1 HELRO|EnsemblGenome=HelroG161895|UniProtKB=T1ES03 T1ES03 20199353 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG86309|UniProtKB=T1G6A2 T1G6A2 20216599 PTHR47227:SF5 DNA-DIRECTED RNA POLYMERASE SUBUNIT K DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2 catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;RNA polymerase activity#GO:0097747;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;RNA polymerase III activity#GO:0001056;RNA polymerase II activity#GO:0001055;RNA polymerase I activity#GO:0001054 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;tRNA metabolic process#GO:0006399;RNA metabolic process#GO:0016070;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;transcription by RNA polymerase I#GO:0006360;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;heterocycle metabolic process#GO:0046483;transcription by RNA polymerase III#GO:0006383;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;ncRNA transcription#GO:0098781;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388;General transcription regulation#P00023>RNA Polymerase II#P00660 HELRO|EnsemblGenome=HelroG175095|UniProtKB=T1F8U3 T1F8U3 20205242 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG109431|UniProtKB=T1EET8 T1EET8 20195090 PTHR46379:SF1 ZINC FINGER MYND DOMAIN-CONTAINING ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 11 protein binding#GO:0005515;methylated histone binding#GO:0035064;histone binding#GO:0042393;binding#GO:0005488;modification-dependent protein binding#GO:0140030 regulation of DNA-templated transcription elongation#GO:0032784;regulation of transcription elongation by RNA polymerase II#GO:0034243;regulation of cell communication#GO:0010646;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of signaling#GO:0023051;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG192727|UniProtKB=T1FU85 T1FU85 20212381 PTHR18898:SF2 NUCLEOPROTEIN TPR-RELATED NUCLEOPROTEIN TPR structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056 mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;mRNA transport#GO:0051028;RNA localization#GO:0006403;localization#GO:0051179;organic substance transport#GO:0071702;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 envelope#GO:0031975;nuclear pore#GO:0005643;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 primary active transporter#PC00068;transporter#PC00227 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG171436|UniProtKB=T1F4A0 T1F4A0 20203649 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG93558|UniProtKB=T1G8W5 T1G8W5 20217512 PTHR11573:SF6 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;oxidoreductase activity#GO:0016491;ATP binding#GO:0005524 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;carbohydrate derivative biosynthetic process#GO:1901137;organic cyclic compound metabolic process#GO:1901360;nucleobase-containing compound biosynthetic process#GO:0034654;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;nucleobase-containing small molecule metabolic process#GO:0055086 cytoplasm#GO:0005737;oxidoreductase complex#GO:1990204;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 reductase#PC00198;oxidoreductase#PC00176 De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>CDP Reductase#P02915;De novo purine biosynthesis#P02738>ADP reductase#P02902;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>UDP reductase#P02921;De novo purine biosynthesis#P02738>GDP reductase#P02909 HELRO|EnsemblGenome=HelroG149307|UniProtKB=T1EKC6 T1EKC6 20197026 PTHR45992:SF2 EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED EUKARYOTIC ELONGATION FACTOR 2 KINASE transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 response to organic substance#GO:0010033;response to organic cyclic compound#GO:0014070;protein-containing complex disassembly#GO:0032984;response to oxygen-containing compound#GO:1901700;cellular component organization#GO:0016043;cellular process#GO:0009987;response to stimulus#GO:0050896;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;cellular component disassembly#GO:0022411;response to chemical#GO:0042221;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036 Oxidative stress response#P00046>eEF2K#P01127;p38 MAPK pathway#P05918>eEF2K#P06022 HELRO|EnsemblGenome=HelroG168792|UniProtKB=T1F0Z2 T1F0Z2 20202492 PTHR20908:SF1 LD15586P LD15586P hydrolase activity#GO:0016787;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171 HELRO|EnsemblGenome=HelroG155980|UniProtKB=T1ELQ3 T1ELQ3 20197503 PTHR46141:SF1 SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN SODIUM LEAK CHANNEL NALCN monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215 regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;positive regulation of cell communication#GO:0010647;regulation of signaling#GO:0023051;biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177;positive regulation of synaptic transmission#GO:0050806;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG176748|UniProtKB=T1FAV4 T1FAV4 20205953 PTHR34098:SF1 F-BOX ONLY PROTEIN 47 F-BOX ONLY PROTEIN 47 HELRO|EnsemblGenome=HelroG97485|UniProtKB=T1G9H2 T1G9H2 20217719 PTHR33562:SF18 ATILLA, ISOFORM B-RELATED-RELATED BOUDIN-RELATED HELRO|EnsemblGenome=HelroG161131|UniProtKB=T1ER45 T1ER45 20199045 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191614|UniProtKB=T1FT46 T1FT46 20211993 PTHR20870:SF0 BARDET-BIEDL SYNDROME 1 PROTEIN BARDET-BIEDL SYNDROME 1 PROTEIN protein binding#GO:0005515;G protein-coupled receptor binding#GO:0001664;binding#GO:0005488;signaling receptor binding#GO:0005102 non-motile cilium assembly#GO:1905515;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;cilium assembly#GO:0060271;cell projection organization#GO:0030030;macromolecule localization#GO:0033036;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;protein localization#GO:0008104;localization#GO:0051179;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular macromolecule localization#GO:0070727;protein localization to cilium#GO:0061512;organelle organization#GO:0006996;protein localization to organelle#GO:0033365;plasma membrane bounded cell projection assembly#GO:0120031 axoneme#GO:0005930;microtubule organizing center#GO:0005815;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;ciliary plasm#GO:0097014;plasma membrane bounded cell projection cytoplasm#GO:0032838;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cytoskeleton#GO:0005856;BBSome#GO:0034464;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG159942|UniProtKB=T1EPL1 T1EPL1 20198511 PTHR24243:SF224 G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTOR 19-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG156203|UniProtKB=T1ELS6 T1ELS6 20197526 PTHR33588:SF1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 299 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 299 structural protein#PC00211 HELRO|EnsemblGenome=HelroG114439|UniProtKB=T1EG17 T1EG17 20195519 PTHR23359:SF242 NUCLEOTIDE KINASE GTP:AMP PHOSPHOTRANSFERASE, MITOCHONDRIAL transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;phosphotransferase activity, phosphate group as acceptor#GO:0016776 cellular aromatic compound metabolic process#GO:0006725;nucleoside triphosphate metabolic process#GO:0009141;purine ribonucleoside monophosphate metabolic process#GO:0009167;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;nucleoside monophosphate metabolic process#GO:0009123;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;purine nucleoside monophosphate metabolic process#GO:0009126;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribonucleoside monophosphate metabolic process#GO:0009161;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 nucleotide kinase#PC00172;kinase#PC00137 De novo purine biosynthesis#P02738>Adenylate kinase#P02896 HELRO|EnsemblGenome=HelroG90920|UniProtKB=T1G7Y0 T1G7Y0 20217177 PTHR23040:SF1 FAMILY NOT NAMED OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 4 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG153303|UniProtKB=T1EL28 T1EL28 20197278 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG84702|UniProtKB=T1G5M5 T1G5M5 20216372 PTHR13131:SF5 CYSTINOSIN CYSTINOSIN L-amino acid transmembrane transporter activity#GO:0015179;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171;organic anion transmembrane transporter activity#GO:0008514;organic acid transmembrane transporter activity#GO:0005342;transporter activity#GO:0005215 localization#GO:0051179;neutral amino acid transport#GO:0015804;organic substance transport#GO:0071702;L-amino acid transport#GO:0015807;establishment of localization#GO:0051234;organic anion transport#GO:0015711;amino acid transport#GO:0006865;organic acid transport#GO:0015849;transport#GO:0006810;nitrogen compound transport#GO:0071705;carboxylic acid transport#GO:0046942 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuolar membrane#GO:0005774;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 amino acid transporter#PC00046;transporter#PC00227 HELRO|EnsemblGenome=HelroG164855|UniProtKB=T1EVW2 T1EVW2 20200712 PTHR23312:SF8 ARMC5 ARMADILLO REPEAT-CONTAINING -RELATED ARMADILLO REPEAT-CONTAINING PROTEIN 5 anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;developmental process#GO:0032502 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG176057|UniProtKB=T1FA35 T1FA35 20205684 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162029|UniProtKB=T1ES57 T1ES57 20199407 PTHR33332:SF48 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG62632|UniProtKB=T1FX29 T1FX29 20213377 PTHR20921:SF0 TRANSMEMBRANE PROTEIN 222 TRANSMEMBRANE PROTEIN 222 HELRO|EnsemblGenome=HelroG173409|UniProtKB=T1F6S5 T1F6S5 20204524 PTHR48209:SF2 AGL056WP FI24008P1 HELRO|EnsemblGenome=HelroG163021|UniProtKB=T1ETK9 T1ETK9 20199909 PTHR11905:SF159 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG165074|UniProtKB=T1EW93 T1EW93 20200843 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG190644|UniProtKB=T1FS59 T1FS59 20211656 PTHR10073:SF12 DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL DNA MISMATCH REPAIR PROTEIN MLH1 pyrophosphatase activity#GO:0016462;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ATP hydrolysis activity#GO:0016887;ribonucleoside triphosphate phosphatase activity#GO:0017111 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;mismatch repair#GO:0006298;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG179632|UniProtKB=T1FEY8 T1FEY8 20207387 PTHR22776:SF49 MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN MARVEL DOMAIN-CONTAINING PROTEIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG193461|UniProtKB=T1FV06 T1FV06 20212652 PTHR24064:SF577 SOLUTE CARRIER FAMILY 22 MEMBER GH09241P secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG143758|UniProtKB=T1EJC1 T1EJC1 20196671 PTHR19818:SF157 ZINC FINGER PROTEIN ZIC AND GLI C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG162271|UniProtKB=T1ESF8 T1ESF8 20199508 PTHR34343:SF1 SEROLOGICALLY DEFINED COLON CANCER ANTIGEN 8 SEROLOGICALLY DEFINED COLON CANCER ANTIGEN 8 establishment or maintenance of cell polarity#GO:0007163;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;developmental process#GO:0032502;multicellular organism development#GO:0007275;microtubule cytoskeleton organization#GO:0000226;tube development#GO:0035295;cell motility#GO:0048870;cellular component organization#GO:0016043;nervous system development#GO:0007399;cellular process#GO:0009987;microtubule organizing center organization#GO:0031023;anatomical structure formation involved in morphogenesis#GO:0048646;cellular component organization or biogenesis#GO:0071840;cell differentiation#GO:0030154;establishment of cell polarity#GO:0030010;system development#GO:0048731;microtubule-based process#GO:0007017;anatomical structure morphogenesis#GO:0009653;organelle organization#GO:0006996;tube morphogenesis#GO:0035239;anatomical structure development#GO:0048856;neuron migration#GO:0001764;multicellular organismal process#GO:0032501;cytoskeleton organization#GO:0007010;generation of neurons#GO:0048699;cell migration#GO:0016477 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;centriole#GO:0005814;organelle#GO:0043226;intracellular organelle#GO:0043229;centrosome#GO:0005813;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG162708|UniProtKB=T1ET15 T1ET15 20199715 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG187684|UniProtKB=T1FPB9 T1FPB9 20210666 PTHR46596:SF1 SORTING NEXIN-4 SORTING NEXIN-4 phosphatidylinositol-3-phosphate binding#GO:0032266;lipid binding#GO:0008289;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981;binding#GO:0005488 cellular localization#GO:0051641;positive regulation of organelle organization#GO:0010638;regulation of catabolic process#GO:0009894;macromolecule localization#GO:0033036;positive regulation of cellular metabolic process#GO:0031325;transport#GO:0006810;positive regulation of cellular catabolic process#GO:0031331;nitrogen compound transport#GO:0071705;regulation of cellular component organization#GO:0051128;establishment of protein localization#GO:0045184;regulation of biological process#GO:0050789;organic substance transport#GO:0071702;positive regulation of metabolic process#GO:0009893;establishment of localization#GO:0051234;regulation of cellular component biogenesis#GO:0044087;regulation of organelle assembly#GO:1902115;positive regulation of cellular component biogenesis#GO:0044089;positive regulation of biological process#GO:0048518;regulation of autophagy#GO:0010506;regulation of organelle organization#GO:0033043;regulation of macroautophagy#GO:0016241;regulation of cellular catabolic process#GO:0031329;cellular process#GO:0009987;protein localization#GO:0008104;positive regulation of cellular process#GO:0048522;localization#GO:0051179;positive regulation of macroautophagy#GO:0016239;cellular macromolecule localization#GO:0070727;regulation of cellular process#GO:0050794;protein transport#GO:0015031;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;positive regulation of catabolic process#GO:0009896;positive regulation of autophagy#GO:0010508;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;SNARE complex#GO:0031201;early endosome#GO:0005769;organelle membrane#GO:0031090;cell periphery#GO:0071944;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endosome membrane#GO:0010008;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;early endosome membrane#GO:0031901;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cytoplasmic vesicle membrane#GO:0030659;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG68255|UniProtKB=T1FZC0 T1FZC0 20214168 PTHR45832:SF8 SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG112831|UniProtKB=T1EFM4 T1EFM4 20195376 PTHR24031:SF84 RNA HELICASE EUKARYOTIC INITIATION FACTOR 4A nucleic acid binding#GO:0003676;translation regulator activity#GO:0045182;translation regulator activity, nucleic acid binding#GO:0090079;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation initiation factor activity#GO:0003743;translation factor activity, RNA binding#GO:0008135 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cytoplasmic translation#GO:0002181;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cytoplasmic translational initiation#GO:0002183;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;translational initiation#GO:0006413;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;cytoplasmic stress granule#GO:0010494;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG180408|UniProtKB=T1FFW2 T1FFW2 20207711 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG113558|UniProtKB=T1EFT6 T1EFT6 20195438 PTHR11247:SF8 PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1 PALMITOYL-PROTEIN THIOESTERASE 1 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;thiolester hydrolase activity#GO:0016790 cytoplasm#GO:0005737;lysosome#GO:0005764;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;vacuole#GO:0005773;cellular anatomical entity#GO:0110165;lytic vacuole#GO:0000323;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG194924|UniProtKB=T1FWK6 T1FWK6 20213201 PTHR12300:SF117 HVA22-LIKE PROTEINS LP05237P-RELATED membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG168248|UniProtKB=T1F0C7 T1F0C7 20202277 PTHR24248:SF125 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR DOPAMINE D2-LIKE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG115347|UniProtKB=T1EG76 T1EG76 20195578 PTHR12027:SF102 WNT RELATED PROTEIN WNT molecular function activator activity#GO:0140677;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;protein binding#GO:0005515;cytokine activity#GO:0005125;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;neurogenesis#GO:0022008;developmental process#GO:0032502;multicellular organism development#GO:0007275;cell communication#GO:0007154;cell fate commitment#GO:0045165;cell-cell signaling by wnt#GO:0198738;nervous system development#GO:0007399;cellular process#GO:0009987;regulation of biological process#GO:0050789;system development#GO:0048731;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;cell-cell signaling#GO:0007267;signaling#GO:0023052;canonical Wnt signaling pathway#GO:0060070;Wnt signaling pathway#GO:0016055 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Cadherin signaling pathway#P00012>Wnt#P00474 HELRO|EnsemblGenome=HelroG99188|UniProtKB=T1G9R3 T1G9R3 20217809 PTHR16119:SF17 TRANSMEMBRANE PROTEIN 144 TRANSMEMBRANE PROTEIN 144 HELRO|EnsemblGenome=HelroG81318|UniProtKB=T1G4C9 T1G4C9 20215927 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG169842|UniProtKB=T1F2D3 T1F2D3 20202983 PTHR24243:SF230 G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG110480|UniProtKB=T1EF26 T1EF26 20195178 PTHR43908:SF3 AT29763P-RELATED AT29763P-RELATED heat shock protein binding#GO:0031072;protein binding#GO:0005515;protein-folding chaperone binding#GO:0051087;binding#GO:0005488;Hsp70 protein binding#GO:0030544 response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;macromolecule biosynthetic process#GO:0009059;chaperone cofactor-dependent protein refolding#GO:0051085;cellular response to chemical stimulus#GO:0070887;chaperone-mediated protein folding#GO:0061077;macromolecule metabolic process#GO:0043170;cellular response to organic substance#GO:0071310;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;cellular response to topologically incorrect protein#GO:0035967;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;response to topologically incorrect protein#GO:0035966;'de novo' protein folding#GO:0006458;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG70673|UniProtKB=T1G0A5 T1G0A5 20214503 PTHR10159:SF529 DUAL SPECIFICITY PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 regulation of MAPK cascade#GO:0043408;negative regulation of biological process#GO:0048519;macromolecule modification#GO:0043412;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;protein modification process#GO:0036211;regulation of intracellular signal transduction#GO:1902531;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;negative regulation of MAPK cascade#GO:0043409;nitrogen compound metabolic process#GO:0006807;regulation of signal transduction#GO:0009966;protein metabolic process#GO:0019538;negative regulation of cellular process#GO:0048523;negative regulation of cell communication#GO:0010648;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;regulation of cell communication#GO:0010646;negative regulation of response to stimulus#GO:0048585;macromolecule metabolic process#GO:0043170;negative regulation of signaling#GO:0023057;cellular metabolic process#GO:0044237;protein dephosphorylation#GO:0006470;organonitrogen compound metabolic process#GO:1901564;cellular process#GO:0009987;primary metabolic process#GO:0044238;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;dephosphorylation#GO:0016311;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG167294|UniProtKB=T1EZ82 T1EZ82 20201882 PTHR10579:SF43 CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG85494|UniProtKB=T1G5Y0 T1G5Y0 20216477 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG98648|UniProtKB=T1G9P2 T1G9P2 20217788 PTHR11477:SF0 TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN IP08861P-RELATED cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG111583|UniProtKB=T1EFC6 T1EFC6 20195278 PTHR47980:SF19 LD44762P RAS-RELATED PROTEIN RAB-3 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;cytoskeletal protein binding#GO:0008092;myosin binding#GO:0017022;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;ribonucleoside triphosphate phosphatase activity#GO:0017111 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;protein secretion#GO:0009306;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;establishment of protein localization to extracellular region#GO:0035592;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;protein transport#GO:0015031;protein localization to extracellular region#GO:0071692;export from cell#GO:0140352;secretion by cell#GO:0032940 presynapse#GO:0098793;synapse#GO:0045202;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;secretory vesicle#GO:0099503;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG194911|UniProtKB=T1FWK0 T1FWK0 20213195 PTHR11003:SF334 POTASSIUM CHANNEL, SUBFAMILY K FI03418P monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG165758|UniProtKB=T1EX94 T1EX94 20201194 PTHR45797:SF1 RAD54-LIKE HELICASE ARIP4 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG186289|UniProtKB=T1FNX5 T1FNX5 20210522 PTHR13296:SF0 BCAS2 PROTEIN PRE-MRNA-SPLICING FACTOR SPF27 ribonucleoprotein complex#GO:1990904;catalytic step 2 spliceosome#GO:0071013;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;precatalytic spliceosome#GO:0071011;cellular anatomical entity#GO:0110165;organelle#GO:0043226;Prp19 complex#GO:0000974;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG160790|UniProtKB=T1EQQ4 T1EQQ4 20198904 PTHR11214:SF364 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE HEXOSYLTRANSFERASE transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG64663|UniProtKB=T1FXX6 T1FXX6 20213674 PTHR12469:SF2 PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL cellular component biogenesis#GO:0044085;mitochondrial respiratory chain complex assembly#GO:0033108;macromolecule modification#GO:0043412;aerobic electron transport chain#GO:0019646;protein-containing complex assembly#GO:0065003;protein modification process#GO:0036211;electron transport chain#GO:0022900;ATP synthesis coupled electron transport#GO:0042773;energy derivation by oxidation of organic compounds#GO:0015980;tricarboxylic acid cycle#GO:0006099;nitrogen compound metabolic process#GO:0006807;respiratory electron transport chain#GO:0022904;mitochondrion organization#GO:0007005;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular component assembly#GO:0022607;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;macromolecule metabolic process#GO:0043170;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;organonitrogen compound metabolic process#GO:1901564;cellular component organization#GO:0016043;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;mitochondrial ATP synthesis coupled electron transport#GO:0042775;mitochondrial respiratory chain complex II assembly#GO:0034553;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;oxidative phosphorylation#GO:0006119;mitochondrial electron transport, succinate to ubiquinone#GO:0006121 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG168434|UniProtKB=T1F0L3 T1F0L3 20202363 PTHR22765:SF416 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE GODZILLA transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG158785|UniProtKB=T1EN94 T1EN94 20198044 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG190500|UniProtKB=T1FS17 T1FS17 20211614 PTHR31395:SF23 SHISA GEO05642P1 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG192979|UniProtKB=T1FUH3 T1FUH3 20212469 PTHR13142:SF1 INNER CENTROMERE PROTEIN INNER CENTROMERE PROTEIN HELRO|EnsemblGenome=HelroG72882|UniProtKB=T1G166 T1G166 20214814 PTHR11616:SF303 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER INE inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;organic acid:sodium symporter activity#GO:0005343;organic acid transmembrane transporter activity#GO:0005342;symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;organic anion transmembrane transporter activity#GO:0008514;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;amino acid:sodium symporter activity#GO:0005283;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;amino acid transmembrane transporter activity#GO:0015171;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;organic anion transport#GO:0015711;amino acid transport#GO:0006865;organic acid transport#GO:0015849;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;nitrogen compound transport#GO:0071705;carboxylic acid transport#GO:0046942;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;amino acid import across plasma membrane#GO:0089718;carboxylic acid transmembrane transport#GO:1905039;localization#GO:0051179;organic substance transport#GO:0071702;import across plasma membrane#GO:0098739;amino acid transmembrane transport#GO:0003333;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transport#GO:0006812;organic acid transmembrane transport#GO:1903825;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG153277|UniProtKB=T1EL24 T1EL24 20197274 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG187670|UniProtKB=T1FPB8 T1FPB8 20210665 PTHR11134:SF3 ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER AP COMPLEX SUBUNIT BETA localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;cellular process#GO:0009987;transport#GO:0006810 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG158167|UniProtKB=T1EMJ9 T1EMJ9 20197799 PTHR24353:SF153 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;cytosol#GO:0005829;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Enkephalin release#P05913>PKA#P05972;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Endothelin signaling pathway#P00019>PKA#P00570;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059 HELRO|EnsemblGenome=HelroG182961|UniProtKB=T1FJ00 T1FJ00 20208799 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED single-stranded RNA binding#GO:0003727;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;poly(A) binding#GO:0008143;binding#GO:0005488;organic cyclic compound binding#GO:0097159 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG190817|UniProtKB=T1FSB4 T1FSB4 20211711 PTHR21092:SF0 NICASTRIN NICASTRIN macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 Notch signaling pathway#P00045>Nicastrin#P01108;Alzheimer disease-presenilin pathway#P00004>Nicastrin#P00115;Alzheimer disease-amyloid secretase pathway#P00003>Nicastrin#P00095 HELRO|EnsemblGenome=HelroG194132|UniProtKB=T1FVQ4 T1FVQ4 20212900 PTHR24023:SF1095 COLLAGEN ALPHA EGF-LIKE DOMAIN-CONTAINING PROTEIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Integrin alpha#P00941;Integrin signalling pathway#P00034>Collagen#P00922 HELRO|EnsemblGenome=HelroG133373|UniProtKB=T1EI04 T1EI04 20196204 PTHR24044:SF504 NOTCH LIGAND FAMILY MEMBER EGF-LIKE DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 regulation of cell communication#GO:0010646;signal transduction#GO:0007165;negative regulation of biological process#GO:0048519;cellular response to stimulus#GO:0051716;negative regulation of response to stimulus#GO:0048585;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;cell communication#GO:0007154;cellular process#GO:0009987;negative regulation of Notch signaling pathway#GO:0045746;regulation of Notch signaling pathway#GO:0008593;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of cell communication#GO:0010648;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;Notch signaling pathway#GO:0007219 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG191553|UniProtKB=T1FT27 T1FT27 20211974 PTHR22988:SF66 MYOTONIC DYSTROPHY S/T KINASE-RELATED SERINE_THREONINE-PROTEIN KINASE GENGHIS KHAN transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;actomyosin structure organization#GO:0031032;cellular component organization#GO:0016043;protein phosphorylation#GO:0006468;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;peptidyl-threonine phosphorylation#GO:0018107;organelle organization#GO:0006996;nitrogen compound metabolic process#GO:0006807;cytoskeleton organization#GO:0007010;phosphorylation#GO:0016310;actin cytoskeleton organization#GO:0030036;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG178174|UniProtKB=T1FCW1 T1FCW1 20206660 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG109631|UniProtKB=T1EEV3 T1EEV3 20195105 PTHR24044:SF502 NOTCH LIGAND FAMILY MEMBER ANTERIOR PHARYNX IN EXCESS PROTEIN 1-RELATED protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG153264|UniProtKB=T1EL21 T1EL21 20197271 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG80468|UniProtKB=T1G414 T1G414 20215812 PTHR24353:SF37 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;GABA-B receptor II signaling#P05731>PKA#P05752;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Enkephalin release#P05913>PKA#P05972;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Endothelin signaling pathway#P00019>PKG#P00567;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Endothelin signaling pathway#P00019>PKA#P00570;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059 HELRO|EnsemblGenome=HelroG86659|UniProtKB=T1G6F0 T1G6F0 20216647 PTHR10887:SF419 DNA2/NAM7 HELICASE FAMILY RNA HELICASE MOV10L1 negative regulation of gene expression#GO:0010629;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulatory ncRNA-mediated post-transcriptional gene silencing#GO:0035194;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;P granule#GO:0043186;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG63652|UniProtKB=T1FXI7 T1FXI7 20213535 PTHR45832:SF22 SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED HELRO|EnsemblGenome=HelroG183772|UniProtKB=T1FK63 T1FK63 20209212 PTHR11256:SF48 BCL-2 RELATED BCL-2-RELATED OVARIAN KILLER PROTEIN protein binding#GO:0005515;binding#GO:0005488 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of cysteine-type endopeptidase activity involved in apoptotic process#GO:0043280;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;signal transduction#GO:0007165;positive regulation of cysteine-type endopeptidase activity#GO:2001056;regulation of protein metabolic process#GO:0051246;apoptotic mitochondrial changes#GO:0008637;regulation of cysteine-type endopeptidase activity#GO:2000116;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;positive regulation of proteolysis#GO:0045862;regulation of biological process#GO:0050789;activation of cysteine-type endopeptidase activity involved in apoptotic process#GO:0006919;DNA damage response#GO:0006974;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;apoptotic process#GO:0006915;cell death#GO:0008219;regulation of hydrolase activity#GO:0051336;mitochondrion organization#GO:0007005;intracellular signal transduction#GO:0035556;positive regulation of biological process#GO:0048518;positive regulation of peptidase activity#GO:0010952;signaling#GO:0023052;regulation of proteolysis#GO:0030162;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;programmed cell death#GO:0012501;cell communication#GO:0007154;cellular component organization#GO:0016043;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of hydrolase activity#GO:0051345;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;intrinsic apoptotic signaling pathway#GO:0097193;apoptotic signaling pathway#GO:0097190;response to stimulus#GO:0050896;positive regulation of protein metabolic process#GO:0051247;response to stress#GO:0006950;extrinsic apoptotic signaling pathway#GO:0097191;regulation of macromolecule metabolic process#GO:0060255;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;regulation of endopeptidase activity#GO:0052548;regulation of cysteine-type endopeptidase activity involved in apoptotic process#GO:0043281;regulation of peptidase activity#GO:0052547;release of cytochrome c from mitochondria#GO:0001836;cellular response to stress#GO:0033554;positive regulation of endopeptidase activity#GO:0010950;regulation of metabolic process#GO:0019222 bounding membrane of organelle#GO:0098588;envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial outer membrane#GO:0005741;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867 Apoptosis signaling pathway#P00006>Bok#P00261 HELRO|EnsemblGenome=HelroG183748|UniProtKB=T1FK49 T1FK49 20209198 PTHR24020:SF84 COLLAGEN ALPHA VWFA DOMAIN-CONTAINING PROTEIN extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG185727|UniProtKB=T1FN74 T1FN74 20210272 PTHR12737:SF9 DIMETHYLARGININE DIMETHYLAMINOHYDROLASE DIMETHYLARGININASE amino acid binding#GO:0016597;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;carboxylic acid binding#GO:0031406;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;anion binding#GO:0043168;ion binding#GO:0043167;organic acid binding#GO:0043177 positive regulation of nitrogen compound metabolic process#GO:0051173;oxoacid metabolic process#GO:0043436;regulation of nitrogen compound metabolic process#GO:0051171;arginine metabolic process#GO:0006525;positive regulation of cellular metabolic process#GO:0031325;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;alpha-amino acid metabolic process#GO:1901605;carboxylic acid metabolic process#GO:0019752;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;amino acid metabolic process#GO:0006520;regulation of cellular metabolic process#GO:0031323;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG181328|UniProtKB=T1FGW3 T1FGW3 20208062 PTHR10476:SF2 CHARGED MULTIVESICULAR BODY PROTEIN CHARGED MULTIVESICULAR BODY PROTEIN 1B-RELATED endosomal transport#GO:0016197;cellular localization#GO:0051641;macromolecule localization#GO:0033036;vacuolar transport#GO:0007034;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;late endosome to vacuole transport#GO:0045324;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;endosome transport via multivesicular body sorting pathway#GO:0032509;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endosome membrane#GO:0010008;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG156707|UniProtKB=T1EM01 T1EM01 20197601 PTHR12356:SF18 NUCLEAR MOVEMENT PROTEIN NUDC NUDC DOMAIN-CONTAINING PROTEIN 2 protein binding#GO:0005515;unfolded protein binding#GO:0051082;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG185345|UniProtKB=T1FMP7 T1FMP7 20210096 PTHR13164:SF3 CALICYLIN BINDING PROTEIN CALCYCLIN-BINDING PROTEIN membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG180212|UniProtKB=T1FFK8 T1FFK8 20207607 PTHR43968:SF6 FAMILY NOT NAMED GLUTATHIONE S-TRANSFERASE OMEGA cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG188305|UniProtKB=T1FPU7 T1FPU7 20210844 PTHR21119:SF5 C2 DOMAIN-CONTAINING PROTEIN C2 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171762|UniProtKB=T1F4M2 T1F4M2 20203771 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG94426|UniProtKB=T1G912 T1G912 20217559 PTHR15592:SF27 MATRIN 3/NUCLEAR PROTEIN 220-RELATED HEPHAESTUS, ISOFORM Y nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nitrogen compound metabolic process#GO:0051171;regulation of biosynthetic process#GO:0009889;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG186070|UniProtKB=T1FNM6 T1FNM6 20210423 PTHR43184:SF12 MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B SUGAR PHOSPHATE EXCHANGER 3 transporter#PC00227 HELRO|EnsemblGenome=HelroG159791|UniProtKB=T1EPE8 T1EPE8 20198448 PTHR12901:SF10 SPERM PROTEIN HOMOLOG COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG184947|UniProtKB=T1FM72 T1FM72 20209921 PTHR13768:SF2 SOLUBLE NSF ATTACHMENT PROTEIN SNAP GAMMA-SOLUBLE NSF ATTACHMENT PROTEIN membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG194550|UniProtKB=T1FW67 T1FW67 20213063 PTHR21330:SF1 E3 SUMO-PROTEIN LIGASE NSE2 E3 SUMO-PROTEIN LIGASE NSE2 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;SUMO transferase activity#GO:0019789;SUMO ligase activity#GO:0061665;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;double-strand break repair#GO:0006302;macromolecule modification#GO:0043412;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;post-translational protein modification#GO:0043687;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;recombinational repair#GO:0000725;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;protein modification by small protein conjugation or removal#GO:0070647;macromolecule metabolic process#GO:0043170;protein sumoylation#GO:0016925;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;double-strand break repair via homologous recombination#GO:0000724;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;catalytic complex#GO:1902494;transferase complex#GO:1990234;condensed chromosome#GO:0000793;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG170806|UniProtKB=T1F3G4 T1F3G4 20203363 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192345|UniProtKB=T1FTU6 T1FTU6 20212243 PTHR13227:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 2A EUKARYOTIC TRANSLATION INITIATION FACTOR 2A tRNA binding#GO:0000049;nucleic acid binding#GO:0003676;translation regulator activity#GO:0045182;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation initiation factor activity#GO:0003743;ribonucleoprotein complex binding#GO:0043021;ribosome binding#GO:0043022;mRNA binding#GO:0003729;protein-containing complex binding#GO:0044877;translation regulator activity, nucleic acid binding#GO:0090079;translation factor activity, RNA binding#GO:0008135 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;small ribosomal subunit#GO:0015935;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 Gonadotropin-releasing hormone receptor pathway#P06664>EIF2A#P06762 HELRO|EnsemblGenome=HelroG85564|UniProtKB=T1G5Z4 T1G5Z4 20216491 PTHR10264:SF127 BAND 7 PROTEIN-RELATED PODOCIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG188096|UniProtKB=T1FPM5 T1FPM5 20210772 PTHR14130:SF14 3BP-1 RELATED RHOGAP RHO GTPASE-ACTIVATING PROTEIN 92B nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of cytoskeleton organization#GO:0051493;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;regulation of organelle organization#GO:0033043;regulation of signaling#GO:0023051;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of cellular component organization#GO:0051128;regulation of actin filament-based process#GO:0032970;regulation of intracellular signal transduction#GO:1902531;regulation of small GTPase mediated signal transduction#GO:0051056 cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 G-protein modulator#PC00022;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG195063|UniProtKB=T1FWQ1 T1FWQ1 20213246 PTHR21586:SF0 TIPA PP2C-LIKE DOMAIN-CONTAINING PROTEIN CG9801 HELRO|EnsemblGenome=HelroG121253|UniProtKB=T1EGR1 T1EGR1 20195761 PTHR11309:SF47 FRIZZLED FRIZZLED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;protein binding#GO:0005515;Wnt-protein binding#GO:0017147;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;non-canonical Wnt signaling pathway#GO:0035567;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;cell-cell signaling by wnt#GO:0198738;canonical Wnt signaling pathway#GO:0060070;cell-cell signaling#GO:0007267;signaling#GO:0023052;Wnt signaling pathway#GO:0016055 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Angiogenesis#P00005>Fzd#P00189;Wnt signaling pathway#P00057>Frizzled#P01428;Alzheimer disease-presenilin pathway#P00004>Frizzled#P00119;Cadherin signaling pathway#P00012>Frizzled#P00475 HELRO|EnsemblGenome=HelroG109498|UniProtKB=T1EEU2 T1EEU2 20195094 PTHR14614:SF44 HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN PROTEIN N-LYSINE METHYLTRANSFERASE METTL21D cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG76379|UniProtKB=T1G2J3 T1G2J3 20215291 PTHR43313:SF50 SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C GH26015P catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 lipid metabolic process#GO:0006629;steroid metabolic process#GO:0008202;organic cyclic compound metabolic process#GO:1901360;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG89038|UniProtKB=T1G782 T1G782 20216929 PTHR46098:SF1 TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG87300|UniProtKB=T1G6N9 T1G6N9 20216736 PTHR13677:SF0 LD41638P LD41638P cytoplasm#GO:0005737;endosome#GO:0005768;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;recycling endosome#GO:0055037;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG76126|UniProtKB=T1G2F3 T1G2F3 20215251 PTHR24637:SF388 COLLAGEN NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG181350|UniProtKB=T1FGX1 T1FGX1 20208070 PTHR35270:SF2 FUSELESS, ISOFORM A FUSELESS, ISOFORM A HELRO|EnsemblGenome=HelroG62538|UniProtKB=T1FX20 T1FX20 20213368 PTHR46377:SF1 DUAL SPECIFICITY PROTEIN PHOSPHATASE 19 DUAL SPECIFICITY PROTEIN PHOSPHATASE 19 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 regulation of protein kinase activity#GO:0045859;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;regulation of nitrogen compound metabolic process#GO:0051171;regulation of catalytic activity#GO:0050790;regulation of phosphorus metabolic process#GO:0051174;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of molecular function#GO:0065009;regulation of cellular process#GO:0050794;regulation of protein phosphorylation#GO:0001932;regulation of protein serine/threonine kinase activity#GO:0071900;biological regulation#GO:0065007;regulation of MAP kinase activity#GO:0043405;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of kinase activity#GO:0043549;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG88310|UniProtKB=T1G715 T1G715 20216862 PTHR20371:SF1 ENOLASE-PHOSPHATASE E1 ENOLASE-PHOSPHATASE E1 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;sulfur compound metabolic process#GO:0006790;proteinogenic amino acid biosynthetic process#GO:0170038;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;aspartate family amino acid biosynthetic process#GO:0009067;alpha-amino acid biosynthetic process#GO:1901607;nitrogen compound metabolic process#GO:0006807;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;aspartate family amino acid metabolic process#GO:0009066;small molecule biosynthetic process#GO:0044283;L-amino acid biosynthetic process#GO:0170034;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG82279|UniProtKB=T1G4Q1 T1G4Q1 20216049 PTHR11636:SF5 POU DOMAIN POU DOMAIN MOTIF 3, ISOFORM F sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG81195|UniProtKB=T1G4A9 T1G4A9 20215907 PTHR24416:SF550 TYROSINE-PROTEIN KINASE RECEPTOR FIBROBLAST GROWTH FACTOR RECEPTOR HOMOLOG 1-RELATED signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG194728|UniProtKB=T1FWC7 T1FWC7 20213122 PTHR34724:SF2 OS12G0596101 PROTEIN OS12G0596101 PROTEIN HELRO|EnsemblGenome=HelroG92830|UniProtKB=T1G8L7 T1G8L7 20217414 PTHR11434:SF16 NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;cellular anatomical entity#GO:0110165;membrane#GO:0016020;NADH dehydrogenase complex#GO:0030964;catalytic complex#GO:1902494 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG92884|UniProtKB=T1G8N0 T1G8N0 20217427 PTHR42743:SF11 AMINO-ACID AMINOTRANSFERASE AMINODEOXYCHORISMATE LYASE oxoacid metabolic process#GO:0043436;cellular metabolic process#GO:0044237;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;organic acid metabolic process#GO:0006082;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704 transaminase#PC00216 Alanine biosynthesis#P02724>Branched chain amino acid aminotransferase#P02815;Leucine biosynthesis#P02749>Branched chain amino acid aminotransferase#P03000;Valine biosynthesis#P02785>Branched chain amino acid aminotransferase#P03215;Isoleucine biosynthesis#P02748>Branched chain amino acid aminotransferase#P02994 HELRO|EnsemblGenome=HelroG157901|UniProtKB=T1EMH6 T1EMH6 20197776 PTHR10631:SF3 N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;macromolecule methylation#GO:0043414;tRNA methylation#GO:0030488;organic cyclic compound metabolic process#GO:1901360;methylation#GO:0032259;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;RNA methylation#GO:0001510;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 RNA metabolism protein#PC00031;RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG162250|UniProtKB=T1ESE9 T1ESE9 20199499 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184540|UniProtKB=T1FLF4 T1FLF4 20209653 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG189048|UniProtKB=T1FQL3 T1FQL3 20211110 PTHR23355:SF35 RIBONUCLEASE EXOSOME COMPLEX EXONUCLEASE RRP44 catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;endonuclease activity#GO:0004519;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787;3'-5'-RNA exonuclease activity#GO:0000175;3'-5' exonuclease activity#GO:0008408;exonuclease activity#GO:0004527;RNA nuclease activity#GO:0004540 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;regulation of biological process#GO:0050789;ncRNA metabolic process#GO:0034660;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;mRNA catabolic process#GO:0006402;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;negative regulation of cellular process#GO:0048523;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;nuclear-transcribed mRNA catabolic process#GO:0000956;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;rRNA metabolic process#GO:0016072;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513;exosome (RNase complex)#GO:0000178 RNA metabolism protein#PC00031;exoribonuclease#PC00099 HELRO|EnsemblGenome=HelroG189592|UniProtKB=T1FR65 T1FR65 20211312 PTHR48209:SF2 AGL056WP FI24008P1 HELRO|EnsemblGenome=HelroG98643|UniProtKB=T1G9P1 T1G9P1 20217787 PTHR13872:SF43 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3A transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein glycosylation#GO:0006486;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;protein metabolic process#GO:0019538;protein N-linked glycosylation via asparagine#GO:0018279;glycosylation#GO:0070085;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG165967|UniProtKB=T1EXI5 T1EXI5 20201285 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG114203|UniProtKB=T1EG00 T1EG00 20195502 PTHR11675:SF101 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 5 transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG63454|UniProtKB=T1FXG0 T1FXG0 20213508 PTHR22961:SF13 SER/THR PROTEIN KINASE-TRB TRIBBLES enzyme binding#GO:0019899;protein binding#GO:0005515;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;regulation of catabolic process#GO:0009894;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of proteasomal protein catabolic process#GO:1901800;regulation of protein catabolic process#GO:0042176;regulation of proteolysis involved in protein catabolic process#GO:1903050;regulation of catalytic activity#GO:0050790;positive regulation of proteolysis#GO:0045862;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;regulation of protein serine/threonine kinase activity#GO:0071900;regulation of MAP kinase activity#GO:0043405;positive regulation of biological process#GO:0048518;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;regulation of kinase activity#GO:0043549;regulation of protein kinase activity#GO:0045859;regulation of proteolysis#GO:0030162;positive regulation of proteolysis involved in protein catabolic process#GO:1903052;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;positive regulation of macromolecule metabolic process#GO:0010604;regulation of primary metabolic process#GO:0080090;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of protein metabolic process#GO:0051247;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of protein phosphorylation#GO:0001932;biological regulation#GO:0065007;positive regulation of catabolic process#GO:0009896;positive regulation of protein catabolic process#GO:0045732;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG189162|UniProtKB=T1FQQ5 T1FQQ5 20211152 PTHR12345:SF16 SYNTENIN RELATED X11L, ISOFORM F-RELATED regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;anterograde trans-synaptic signaling#GO:0098916;biological regulation#GO:0065007;synaptic signaling#GO:0099536;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052;cell-cell signaling#GO:0007267 synapse#GO:0045202;somatodendritic compartment#GO:0036477;cell junction#GO:0030054;dendrite#GO:0030425;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;dendritic tree#GO:0097447;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;neuron projection#GO:0043005;postsynapse#GO:0098794;cell projection#GO:0042995;dendritic spine#GO:0043197;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG91627|UniProtKB=T1G866 T1G866 20217263 PTHR10768:SF0 60S RIBOSOMAL PROTEIN L37 RIBOSOMAL PROTEIN L37 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG187805|UniProtKB=T1FPE0 T1FPE0 20210687 PTHR15204:SF0 LARGE PROLINE-RICH PROTEIN BAG6 LARGE PROLINE-RICH PROTEIN BAG6 protein binding#GO:0005515;binding#GO:0005488;modification-dependent protein binding#GO:0140030;polyubiquitin modification-dependent protein binding#GO:0031593 response to organic substance#GO:0010033;macromolecule catabolic process#GO:0009057;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;response to organonitrogen compound#GO:0010243;ERAD pathway#GO:0036503;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG158535|UniProtKB=T1EMX6 T1EMX6 20197926 PTHR46543:SF1 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;modification-dependent macromolecule catabolic process#GO:0043632;regulation of biological process#GO:0050789;ncRNA metabolic process#GO:0034660;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;mRNA catabolic process#GO:0006402;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;negative regulation of cellular process#GO:0048523;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;snRNA metabolic process#GO:0016073;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;nuclear-transcribed mRNA catabolic process#GO:0000956;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;rRNA metabolic process#GO:0016072;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;polyadenylation-dependent ncRNA catabolic process#GO:0043634;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG98557|UniProtKB=T1G9N6 T1G9N6 20217782 PTHR42980:SF1 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL oxoacid metabolic process#GO:0043436;branched-chain amino acid metabolic process#GO:0009081;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;response to nutrient levels#GO:0031667;response to extracellular stimulus#GO:0009991;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;response to external stimulus#GO:0009605;amino acid catabolic process#GO:0009063;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;response to chemical#GO:0042221;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG167698|UniProtKB=T1EZP4 T1EZP4 20202044 PTHR19282:SF527 TETRASPANIN TETRASPANIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG172051|UniProtKB=T1F4Z2 T1F4Z2 20203891 PTHR13028:SF0 RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED RRNA-PROCESSING PROTEIN EBP2-RELATED cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;preribosome, large subunit precursor#GO:0030687;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;nuclear periphery#GO:0034399;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981 HELRO|EnsemblGenome=HelroG152831|UniProtKB=T1EKX5 T1EKX5 20197225 PTHR11256:SF56 BCL-2 RELATED BCL-2 BCL-2 HOMOLOGY REGION 1-3 DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;binding#GO:0005488 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of cysteine-type endopeptidase activity involved in apoptotic process#GO:0043280;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;signal transduction#GO:0007165;positive regulation of cysteine-type endopeptidase activity#GO:2001056;regulation of protein metabolic process#GO:0051246;apoptotic mitochondrial changes#GO:0008637;regulation of cysteine-type endopeptidase activity#GO:2000116;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;positive regulation of proteolysis#GO:0045862;regulation of biological process#GO:0050789;activation of cysteine-type endopeptidase activity involved in apoptotic process#GO:0006919;DNA damage response#GO:0006974;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;apoptotic process#GO:0006915;cell death#GO:0008219;regulation of hydrolase activity#GO:0051336;mitochondrion organization#GO:0007005;intracellular signal transduction#GO:0035556;positive regulation of biological process#GO:0048518;positive regulation of peptidase activity#GO:0010952;signaling#GO:0023052;regulation of proteolysis#GO:0030162;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;programmed cell death#GO:0012501;cell communication#GO:0007154;cellular component organization#GO:0016043;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of hydrolase activity#GO:0051345;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;intrinsic apoptotic signaling pathway#GO:0097193;apoptotic signaling pathway#GO:0097190;response to stimulus#GO:0050896;positive regulation of protein metabolic process#GO:0051247;response to stress#GO:0006950;extrinsic apoptotic signaling pathway#GO:0097191;regulation of macromolecule metabolic process#GO:0060255;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;regulation of endopeptidase activity#GO:0052548;regulation of cysteine-type endopeptidase activity involved in apoptotic process#GO:0043281;regulation of peptidase activity#GO:0052547;release of cytochrome c from mitochondria#GO:0001836;cellular response to stress#GO:0033554;positive regulation of endopeptidase activity#GO:0010950;regulation of metabolic process#GO:0019222 bounding membrane of organelle#GO:0098588;envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial outer membrane#GO:0005741;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867 HELRO|EnsemblGenome=HelroG167766|UniProtKB=T1EZS2 T1EZS2 20202072 PTHR24278:SF19 COAGULATION FACTOR EGF-LIKE DOMAIN-CONTAINING PROTEIN extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG85778|UniProtKB=T1G628 T1G628 20216525 PTHR45905:SF1 GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN enzyme binding#GO:0019899;protein binding#GO:0005515;small GTPase binding#GO:0031267;binding#GO:0005488 localization#GO:0051179;localization within membrane#GO:0051668;cellular localization#GO:0051641;vesicle-mediated transport to the plasma membrane#GO:0098876;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;post-Golgi vesicle-mediated transport#GO:0006892;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;Golgi to plasma membrane transport#GO:0006893;protein localization#GO:0008104 cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi apparatus subcompartment#GO:0098791;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185760|UniProtKB=T1FN91 T1FN91 20210289 PTHR44006:SF1 U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 ribonucleoprotein complex#GO:1990904;catalytic step 2 spliceosome#GO:0071013;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 mRNA splicing#P00058>U5#P01474 HELRO|EnsemblGenome=HelroG187809|UniProtKB=T1FPE2 T1FPE2 20210689 PTHR21402:SF5 GAMETOCYTE SPECIFIC FACTOR 1-RELATED GAMETOCYTE SPECIFIC FACTOR 1 HELRO|EnsemblGenome=HelroG169076|UniProtKB=T1F1D3 T1F1D3 20202633 PTHR14390:SF2 G PATCH DOMAIN CONTAINING PROTEIN 3 G PATCH DOMAIN-CONTAINING PROTEIN 3 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;positive regulation of cellular metabolic process#GO:0031325;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;positive regulation of RNA metabolic process#GO:0051254;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 HELRO|EnsemblGenome=HelroG147323|UniProtKB=T1EJZ3 T1EJZ3 20196893 PTHR11849:SF289 ETS ETS-LIKE PROTEIN POINTED transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 PDGF signaling pathway#P00047>Ets#P01167 HELRO|EnsemblGenome=HelroG167670|UniProtKB=T1EZN2 T1EZN2 20202032 PTHR16501:SF6 TRANSPORT AND GOLGI ORGANIZATION PROTEIN 11 TRANSPORT AND GOLGI ORGANIZATION PROTEIN 11 HELRO|EnsemblGenome=HelroG185751|UniProtKB=T1FN88 T1FN88 20210286 PTHR43866:SF3 MALONATE-SEMIALDEHYDE DEHYDROGENASE METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;heterocycle catabolic process#GO:0046700;branched-chain amino acid metabolic process#GO:0009081;pyrimidine-containing compound metabolic process#GO:0072527;organonitrogen compound catabolic process#GO:1901565;nucleobase metabolic process#GO:0009112;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;pyrimidine nucleobase metabolic process#GO:0006206;amino acid catabolic process#GO:0009063;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;alpha-amino acid metabolic process#GO:1901605;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248;oxoacid metabolic process#GO:0043436;heterocycle metabolic process#GO:0046483;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;pyrimidine nucleobase catabolic process#GO:0006208;organic cyclic compound catabolic process#GO:1901361;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 dehydrogenase#PC00092;oxidoreductase#PC00176 Pyrimidine Metabolism#P02771>Methylmalonate Semialdehyde Dehydrogenase#P03124 HELRO|EnsemblGenome=HelroG75680|UniProtKB=T1G287 T1G287 20215185 PTHR22811:SF14 TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN LP01981P-RELATED endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;Golgi organization#GO:0007030;macromolecule localization#GO:0033036;transport#GO:0006810;endomembrane system organization#GO:0010256;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;organelle organization#GO:0006996;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;endoplasmic reticulum#GO:0005783;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG167450|UniProtKB=T1EZE2 T1EZE2 20201942 PTHR24034:SF200 EGF-LIKE DOMAIN-CONTAINING PROTEIN EGF-LIKE AND EMI DOMAIN-CONTAINING PROTEIN 1 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG164209|UniProtKB=T1EV36 T1EV36 20200436 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165701|UniProtKB=T1EX68 T1EX68 20201168 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG143846|UniProtKB=T1EJC6 T1EJC6 20196676 PTHR46191:SF2 FAMILY NOT NAMED HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 3 HELRO|EnsemblGenome=HelroG159956|UniProtKB=T1EPL4 T1EPL4 20198514 PTHR44303:SF2 DNAJ HOMOLOG SUBFAMILY C MEMBER 16 DNAJ HOMOLOG SUBFAMILY C MEMBER 16 chaperone#PC00072 HELRO|EnsemblGenome=HelroG189001|UniProtKB=T1FQJ7 T1FQJ7 20211094 PTHR22746:SF10 RAB6A-GEF COMPLEX PARTNER PROTEIN 1 GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1 endosomal transport#GO:0016197;cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;cytosolic transport#GO:0016482;establishment of protein localization#GO:0045184;retrograde transport, endosome to Golgi#GO:0042147;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;cytosol#GO:0005829;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;guanyl-nucleotide exchange factor complex#GO:0032045;Golgi membrane#GO:0000139 HELRO|EnsemblGenome=HelroG186259|UniProtKB=T1FNV8 T1FNV8 20210505 PTHR24089:SF59 SOLUTE CARRIER FAMILY 25 MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER transmembrane transporter activity#GO:0022857;organic cation transmembrane transporter activity#GO:0015101;transporter activity#GO:0005215 localization#GO:0051179;organic substance transport#GO:0071702;quaternary ammonium group transport#GO:0015697;organophosphate ester transport#GO:0015748;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;organic anion transport#GO:0015711;organic cation transport#GO:0015695;transport#GO:0006810;vitamin transport#GO:0051180;nitrogen compound transport#GO:0071705;cellular process#GO:0009987 envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;organelle inner membrane#GO:0019866;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227 mitochondrial carrier protein#PC00158;secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG190075|UniProtKB=T1FRN6 T1FRN6 20211483 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG176131|UniProtKB=T1FA67 T1FA67 20205716 PTHR24180:SF45 CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED POLY [ADP-RIBOSE] POLYMERASE TANKYRASE kinase inhibitor#PC00139 HELRO|EnsemblGenome=HelroG93565|UniProtKB=T1G8W6 T1G8W6 20217513 PTHR11846:SF0 ADENYLOSUCCINATE SYNTHETASE ADENYLOSUCCINATE SYNTHETASE ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;purine ribonucleoside monophosphate metabolic process#GO:0009167;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;nucleotide biosynthetic process#GO:0009165;nucleoside monophosphate metabolic process#GO:0009123;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;IMP metabolic process#GO:0046040;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;purine nucleoside monophosphate metabolic process#GO:0009126;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribonucleoside monophosphate metabolic process#GO:0009161;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 Wnt signaling pathway#P00057>NFAT Target Genes#G01559;De novo purine biosynthesis#P02738>Adenylosuccinate synthase#P02890 HELRO|EnsemblGenome=HelroG177977|UniProtKB=T1FCK1 T1FCK1 20206550 PTHR47160:SF8 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG83244|UniProtKB=T1G525 T1G525 20216173 PTHR11920:SF502 GUANYLYL CYCLASE GUANYLATE CYCLASE adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG144803|UniProtKB=T1EJG5 T1EJG5 20196715 PTHR24171:SF8 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;BRCA1-A complex#GO:0070531;nuclear ubiquitin ligase complex#GO:0000152;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG191012|UniProtKB=T1FSH9 T1FSH9 20211776 PTHR31220:SF1 HYCCIN RELATED GH21176P lipid metabolic process#GO:0006629;cellular localization#GO:0051641;phospholipid biosynthetic process#GO:0008654;macromolecule localization#GO:0033036;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;protein localization to plasma membrane#GO:0072659;localization within membrane#GO:0051668;protein localization to membrane#GO:0072657;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;protein localization to cell periphery#GO:1990778;cellular macromolecule localization#GO:0070727;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG90364|UniProtKB=T1G7P9 T1G7P9 20217096 PTHR11654:SF509 OLIGOPEPTIDE TRANSPORTER-RELATED SOLUTE CARRIER FAMILY 15 MEMBER 4 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG135759|UniProtKB=T1EIA4 T1EIA4 20196304 PTHR10828:SF76 M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25 M-PHASE INDUCER PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 regulation of cell cycle G2/M phase transition#GO:1902749;mitotic cell cycle phase transition#GO:0044772;regulation of mitotic cell cycle phase transition#GO:1901990;cell cycle process#GO:0022402;regulation of cell cycle phase transition#GO:1901987;positive regulation of cell cycle#GO:0045787;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047;cell cycle phase transition#GO:0044770;positive regulation of cellular process#GO:0048522;regulation of cell cycle process#GO:0010564;regulation of biological process#GO:0050789;G2/M transition of mitotic cell cycle#GO:0000086;mitotic cell cycle#GO:0000278;regulation of meiotic cell cycle#GO:0051445;regulation of cellular process#GO:0050794;positive regulation of cell cycle process#GO:0090068;positive regulation of mitotic cell cycle#GO:0045931;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of G2/M transition of mitotic cell cycle#GO:0010389;positive regulation of biological process#GO:0048518;regulation of mitotic cell cycle#GO:0007346;cell cycle G2/M phase transition#GO:0044839 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG161955|UniProtKB=T1ES30 T1ES30 20199380 PTHR21963:SF1 PF6 SPERM-ASSOCIATED ANTIGEN 17 cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;microtubule cytoskeleton organization#GO:0000226;cellular component organization#GO:0016043;axoneme assembly#GO:0035082;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;microtubule bundle formation#GO:0001578;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection assembly#GO:0120031 axoneme#GO:0005930;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;axonemal central apparatus#GO:1990716;plasma membrane bounded cell projection cytoplasm#GO:0032838;membrane-bounded organelle#GO:0043227;ciliary plasm#GO:0097014;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG176907|UniProtKB=T1FB15 T1FB15 20206014 PTHR16021:SF23 MANSC DOMAIN CONTAINING PROTEIN 1 FI18411P1-RELATED HELRO|EnsemblGenome=HelroG83053|UniProtKB=T1G4Z6 T1G4Z6 20216144 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG99850|UniProtKB=T1G9V6 T1G9V6 20217852 PTHR11153:SF6 SIDEROFLEXIN SIDEROFLEXIN-5 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;mitochondrial transport#GO:0006839;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;mitochondrial transmembrane transport#GO:1990542;transport#GO:0006810 envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG178956|UniProtKB=T1FDY6 T1FDY6 20207035 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG103911|UniProtKB=T1EDI3 T1EDI3 20194635 PTHR23003:SF51 RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN SERINE-ARGININE PROTEIN 55 nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG187315|UniProtKB=T1FP87 T1FP87 20210634 PTHR13780:SF35 AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT LD22662P kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG193870|UniProtKB=T1FVF6 T1FVF6 20212802 PTHR10666:SF438 UBIQUITIN POLYUBIQUITIN-C structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159;ubiquitin-like protein ligase binding#GO:0044389;enzyme binding#GO:0019899;protein binding#GO:0005515;ubiquitin protein ligase binding#GO:0031625 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;protein modification by small protein conjugation#GO:0032446;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytosolic ribosome#GO:0022626;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;membrane-bounded organelle#GO:0043227;small ribosomal subunit#GO:0015935;ribosome#GO:0005840 HELRO|EnsemblGenome=HelroG164373|UniProtKB=T1EVC1 T1EVC1 20200521 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182809|UniProtKB=T1FIS5 T1FIS5 20208724 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168494|UniProtKB=T1F0M8 T1F0M8 20202378 PTHR12905:SF0 METALLOPHOSPHOESTERASE CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN esterase#PC00097 HELRO|EnsemblGenome=HelroG169375|UniProtKB=T1F1V4 T1F1V4 20202804 PTHR24410:SF47 HL07962P-RELATED BTB DOMAIN-CONTAINING PROTEIN defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG190567|UniProtKB=T1FS35 T1FS35 20211632 PTHR23121:SF9 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 transmembrane transporter activity#GO:0022857;sugar transmembrane transporter activity#GO:0051119;transporter activity#GO:0005215;carbohydrate transmembrane transporter activity#GO:0015144 transporter#PC00227 HELRO|EnsemblGenome=HelroG191131|UniProtKB=T1FSM6 T1FSM6 20211823 PTHR19855:SF12 WD40 REPEAT PROTEIN 12, 37 WD REPEAT-CONTAINING PROTEIN 37 HELRO|EnsemblGenome=HelroG167792|UniProtKB=T1EZT4 T1EZT4 20202084 PTHR11360:SF260 MONOCARBOXYLATE TRANSPORTER MFS DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;monocarboxylic acid transmembrane transporter activity#GO:0008028;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;monocarboxylic acid transport#GO:0015718;establishment of localization#GO:0051234;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942 transporter#PC00227 HELRO|EnsemblGenome=HelroG160466|UniProtKB=T1EQA2 T1EQA2 20198752 PTHR21501:SF1 PROTEIN FAM-161 PROTEIN FAM-161 cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;cellular component organization#GO:0016043;cellular process#GO:0009987;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;organelle organization#GO:0006996 membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cilium#GO:0005929;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG175503|UniProtKB=T1F9C1 T1F9C1 20205420 PTHR43011:SF1 IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;iron-sulfur cluster binding#GO:0051536;iron ion binding#GO:0005506;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;ion binding#GO:0043167 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;iron-sulfur cluster assembly#GO:0016226;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG108067|UniProtKB=T1EEF0 T1EEF0 20194952 PTHR12700:SF12 ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL monoatomic cation channel activity#GO:0005261;ligase activity#GO:0016874;inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;catalytic activity#GO:0003824;proton transmembrane transporter activity#GO:0015078;proton channel activity#GO:0015252;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;inorganic cation transmembrane transporter activity#GO:0022890;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 cellular aromatic compound metabolic process#GO:0006725;ribonucleoside triphosphate metabolic process#GO:0009199;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative metabolic process#GO:1901135;ATP biosynthetic process#GO:0006754;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;purine nucleoside triphosphate biosynthetic process#GO:0009145;heterocycle metabolic process#GO:0046483;purine ribonucleoside triphosphate metabolic process#GO:0009205;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;ribonucleoside triphosphate biosynthetic process#GO:0009201;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;proton motive force-driven ATP synthesis#GO:0015986;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;purine nucleoside triphosphate metabolic process#GO:0009144;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;proton-transporting two-sector ATPase complex, proton-transporting domain#GO:0033177;ATPase complex#GO:1904949;organelle inner membrane#GO:0019866;mitochondrial proton-transporting ATP synthase complex#GO:0005753;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;proton-transporting two-sector ATPase complex#GO:0016469;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)#GO:0000276;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;proton-transporting ATP synthase complex, coupling factor F(o)#GO:0045263;proton-transporting ATP synthase complex#GO:0045259;mitochondrial protein-containing complex#GO:0098798 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG172535|UniProtKB=T1F5H3 T1F5H3 20204072 PTHR23322:SF93 FAS-ASSOCIATED PROTEIN UBX DOMAIN-CONTAINING PROTEIN 8 protein binding#GO:0005515;ubiquitin-like protein binding#GO:0032182;binding#GO:0005488;ubiquitin binding#GO:0043130 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG163378|UniProtKB=T1ETZ3 T1ETZ3 20200043 PTHR10012:SF0 SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR phosphatase regulator activity#GO:0019208;molecular function activator activity#GO:0140677;catalytic activity#GO:0003824;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888;peptidyl-prolyl cis-trans isomerase activity#GO:0003755;enzyme activator activity#GO:0008047;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;enzyme regulator activity#GO:0030234 cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;mitotic spindle organization#GO:0007052;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;cell cycle#GO:0007049;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;spindle organization#GO:0007051;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 phosphatase activator#PC00182;phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG164111|UniProtKB=T1EUY1 T1EUY1 20200381 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159998|UniProtKB=T1EPN0 T1EPN0 20198530 PTHR28617:SF1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 77 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 77 structural protein#PC00211 HELRO|EnsemblGenome=HelroG70078|UniProtKB=T1G024 T1G024 20214422 PTHR10352:SF79 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G TRIVET, ISOFORM I translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG179898|UniProtKB=T1FF87 T1FF87 20207486 PTHR13297:SF9 TBC1 DOMAIN FAMILY MEMBER 23-RELATED ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG81743|UniProtKB=T1G4I3 T1G4I3 20215981 PTHR11348:SF17 CONNECTIVE TISSUE GROWTH FACTOR-RELATED CCN carbohydrate derivative binding#GO:0097367;integrin binding#GO:0005178;binding#GO:0005488;heparin binding#GO:0008201;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;glycosaminoglycan binding#GO:0005539;signaling receptor binding#GO:0005102 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;positive regulation of cell differentiation#GO:0045597;cell communication#GO:0007154;cell adhesion#GO:0007155;cellular process#GO:0009987;regulation of cell differentiation#GO:0045595;positive regulation of developmental process#GO:0051094;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;biological regulation#GO:0065007;signaling#GO:0023052;positive regulation of biological process#GO:0048518 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;extracellular space#GO:0005615;extracellular region#GO:0005576 growth factor#PC00112 HELRO|EnsemblGenome=HelroG174656|UniProtKB=T1F8C8 T1F8C8 20205077 PTHR11927:SF9 GALACTOSIDE 2-L-FUCOSYLTRANSFERASE L-FUCOSYLTRANSFERASE transferase activity#GO:0016740;fucosyltransferase activity#GO:0008417;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein glycosylation#GO:0006486;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycosylation#GO:0070085;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG185657|UniProtKB=T1FN35 T1FN35 20210233 PTHR43028:SF4 3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1 INOSITOL MONOPHOSPHATASE 3 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;nucleotidase activity#GO:0008252;phosphoric ester hydrolase activity#GO:0042578 cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG165760|UniProtKB=T1EX95 T1EX95 20201195 PTHR13341:SF2 MIR-INTERACTING SAPOSIN-LIKE PROTEIN PROTEIN SEELE HELRO|EnsemblGenome=HelroG175225|UniProtKB=T1F915 T1F915 20205314 PTHR24248:SF129 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG117263|UniProtKB=T1EGL5 T1EGL5 20195715 PTHR11208:SF125 RNA-BINDING PROTEIN RELATED KH DOMAIN-CONTAINING RNA-BINDING PROTEIN QKI nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of RNA splicing#GO:0043484;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of mRNA processing#GO:0050684;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;regulation of mRNA metabolic process#GO:1903311 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG159699|UniProtKB=T1EPB8 T1EPB8 20198418 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cell communication#GO:0007154;cellular process#GO:0009987;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;Notch signaling pathway#GO:0007219 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG190559|UniProtKB=T1FS32 T1FS32 20211629 PTHR23113:SF249 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6 nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;Ras protein signal transduction#GO:0007265;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052 plasma membrane region#GO:0098590;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;apical part of cell#GO:0045177;plasma membrane#GO:0005886;apical plasma membrane#GO:0016324 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG192043|UniProtKB=T1FTJ3 T1FTJ3 20212140 PTHR45676:SF41 RING-H2 FINGER PROTEIN ATL51-RELATED RING-H2 FINGER PROTEIN ATL66 HELRO|EnsemblGenome=HelroG189510|UniProtKB=T1FR41 T1FR41 20211288 PTHR14543:SF1 PROTRUDIN PROTRUDIN protein binding#GO:0005515;binding#GO:0005488 protein localization to plasma membrane#GO:0072659;cellular component assembly#GO:0022607;localization within membrane#GO:0051668;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;endoplasmic reticulum organization#GO:0007029;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;transport#GO:0006810;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;protein localization#GO:0008104;localization#GO:0051179;protein localization to cell periphery#GO:1990778;cellular component organization or biogenesis#GO:0071840;cellular macromolecule localization#GO:0070727;endoplasmic reticulum tubular network organization#GO:0071786;establishment of localization#GO:0051234;organelle organization#GO:0006996 cytoplasm#GO:0005737;endoplasmic reticulum tubular network#GO:0071782;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG176402|UniProtKB=T1FAH5 T1FAH5 20205824 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG64826|UniProtKB=T1FXZ9 T1FXZ9 20213697 PTHR13651:SF0 PROTEIN ABITRAM PROTEIN ABITRAM HELRO|EnsemblGenome=HelroG163766|UniProtKB=T1EUG0 T1EUG0 20200210 PTHR21255:SF65 T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN TCTEX1 DOMAIN-CONTAINING PROTEIN 2 protein binding#GO:0005515;binding#GO:0005488 microtubule-based movement#GO:0007018;cellular process#GO:0009987;microtubule-based process#GO:0007017 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;microtubule cytoskeleton#GO:0015630;dynein complex#GO:0030286;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic dynein complex#GO:0005868;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG172107|UniProtKB=T1F513 T1F513 20203912 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG124255|UniProtKB=T1EH06 T1EH06 20195856 PTHR12151:SF5 ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER AT19154P cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;respiratory chain complex IV assembly#GO:0008535;mitochondrial respiratory chain complex assembly#GO:0033108;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;cytochrome complex assembly#GO:0017004;protein-containing complex assembly#GO:0065003;mitochondrial cytochrome c oxidase assembly#GO:0033617;cellular component organization#GO:0016043;mitochondrion organization#GO:0007005;cellular process#GO:0009987 oxidase#PC00175;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG79745|UniProtKB=T1G3S8 T1G3S8 20215726 PTHR11473:SF16 AROMATIC AMINO ACID HYDROXYLASE TRYPTOPHAN 5-HYDROXYLASE 2 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497 cell projection#GO:0042995;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;neuron projection#GO:0043005 oxidoreductase#PC00176 5-Hydroxytryptamine biosynthesis#P04371>Tryptophan hydroxylase#P04399 HELRO|EnsemblGenome=HelroG185274|UniProtKB=T1FML5 T1FML5 20210064 PTHR10476:SF2 CHARGED MULTIVESICULAR BODY PROTEIN CHARGED MULTIVESICULAR BODY PROTEIN 1B-RELATED endosomal transport#GO:0016197;cellular localization#GO:0051641;macromolecule localization#GO:0033036;vacuolar transport#GO:0007034;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;late endosome to vacuole transport#GO:0045324;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;endosome transport via multivesicular body sorting pathway#GO:0032509;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endosome membrane#GO:0010008;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG166439|UniProtKB=T1EY49 T1EY49 20201499 PTHR23338:SF16 SMALL NUCLEAR RIBONUCLEOPROTEIN SM U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM4 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;snRNA binding#GO:0017069;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;spliceosomal snRNP assembly#GO:0000387;P-body assembly#GO:0033962;non-membrane-bounded organelle assembly#GO:0140694;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375 supramolecular complex#GO:0099080;U6 snRNP#GO:0005688;nucleus#GO:0005634;P-body#GO:0000932;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein complex#GO:1990904;ribonucleoprotein granule#GO:0035770;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;spliceosomal tri-snRNP complex#GO:0097526;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG74733|UniProtKB=T1G1U9 T1G1U9 20215047 PTHR48013:SF11 DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED LICORNE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;MAPK cascade#GO:0000165;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 FGF signaling pathway#P00021>MKK3,6#P00625;EGF receptor signaling pathway#P00018>MKK3,6#P00540;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>MEK#P00891 HELRO|EnsemblGenome=HelroG72093|UniProtKB=T1G0V5 T1G0V5 20214703 PTHR23310:SF62 ACYL-COA-BINDING PROTEIN, ACBP ACYL-COA BINDING PROTEIN 1, ISOFORM A carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;amide binding#GO:0033218;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;lipid binding#GO:0008289;anion binding#GO:0043168;ion binding#GO:0043167 lipid metabolic process#GO:0006629;oxoacid metabolic process#GO:0043436;fatty acid metabolic process#GO:0006631;cellular metabolic process#GO:0044237;cellular process#GO:0009987;cellular lipid metabolic process#GO:0044255;organic acid metabolic process#GO:0006082;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG64447|UniProtKB=T1FXV1 T1FXV1 20213649 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG171155|UniProtKB=T1F3V7 T1F3V7 20203506 PTHR46543:SF1 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;modification-dependent macromolecule catabolic process#GO:0043632;regulation of biological process#GO:0050789;ncRNA metabolic process#GO:0034660;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;mRNA catabolic process#GO:0006402;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;negative regulation of cellular process#GO:0048523;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;snRNA metabolic process#GO:0016073;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;nuclear-transcribed mRNA catabolic process#GO:0000956;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;rRNA metabolic process#GO:0016072;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;polyadenylation-dependent ncRNA catabolic process#GO:0043634;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG62499|UniProtKB=T1FX15 T1FX15 20213363 PTHR10336:SF80 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN C2 DOMAIN-CONTAINING PROTEIN hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phospholipase C activity#GO:0004629;phospholipase activity#GO:0004620;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578 lipid metabolic process#GO:0006629;signal transduction#GO:0007165;negative regulation of biological process#GO:0048519;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of sequestering of calcium ion#GO:0051282;regulation of localization#GO:0032879;inorganic ion transmembrane transport#GO:0098660;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;calcium ion transport#GO:0006816;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;glycerolipid metabolic process#GO:0046486;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;intracellular signal transduction#GO:0035556;signaling#GO:0023052;negative regulation of cellular process#GO:0048523;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular response to stimulus#GO:0051716;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;cellular metabolic process#GO:0044237;release of sequestered calcium ion into cytosol#GO:0051209;cell communication#GO:0007154;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;cellular process#GO:0009987;primary metabolic process#GO:0044238;localization#GO:0051179;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;calcium ion transmembrane import into cytosol#GO:0097553;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;monoatomic ion transport#GO:0006811;cellular lipid metabolic process#GO:0044255;negative regulation of sequestering of calcium ion#GO:0051283;monoatomic cation transmembrane transport#GO:0098655 phospholipase#PC00186 HELRO|EnsemblGenome=HelroG102150|UniProtKB=T1ED85 T1ED85 20194537 PTHR23408:SF3 METHYLMALONYL-COA MUTASE METHYLMALONIC ACIDURIA TYPE A PROTEIN, MITOCHONDRIAL hydrolase activity#GO:0016787;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 mutase#PC00160 HELRO|EnsemblGenome=HelroG127118|UniProtKB=T1EHD0 T1EHD0 20195980 PTHR10496:SF0 40S RIBOSOMAL PROTEIN S24 40S RIBOSOMAL PROTEIN S24 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG179666|UniProtKB=T1FF03 T1FF03 20207402 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG170875|UniProtKB=T1F3J3 T1F3J3 20203392 PTHR45615:SF40 MYOSIN HEAVY CHAIN, NON-MUSCLE MYOSIN HEAVY CHAIN, NON-MUSCLE microfilament motor activity#GO:0000146;cytoskeletal protein binding#GO:0008092;ATP-dependent activity#GO:0140657;binding#GO:0005488;actin filament binding#GO:0051015;cytoskeletal motor activity#GO:0003774;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779 supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;supramolecular fiber#GO:0099512;supramolecular polymer#GO:0099081;myosin complex#GO:0016459;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Myosin#P00867;Cytoskeletal regulation by Rho GTPase#P00016>Myosin#P00522;Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG86991|UniProtKB=T1G6K4 T1G6K4 20216701 PTHR11920:SF494 GUANYLYL CYCLASE ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2 adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 Gonadotropin-releasing hormone receptor pathway#P06664>Npr2#P06796;Endothelin signaling pathway#P00019>Guanylate cyclase#P00581 HELRO|EnsemblGenome=HelroG64096|UniProtKB=T1FXP1 T1FXP1 20213589 PTHR45725:SF1 FORMIN HOMOLOGY 2 FAMILY MEMBER DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG174839|UniProtKB=T1F8I9 T1F8I9 20205138 PTHR18905:SF13 NINEIN NON-CENTROSOMAL MICROTUBULE ARRAY microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule-based process#GO:0007017;organelle organization#GO:0006996 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG167419|UniProtKB=T1EZC3 T1EZC3 20201923 PTHR24026:SF126 FAT ATYPICAL CADHERIN-RELATED PROTOCADHERIN FAT 4 cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HELRO|EnsemblGenome=HelroG193253|UniProtKB=T1FUS8 T1FUS8 20212574 PTHR31126:SF1 TYROSINE-PROTEIN PHOSPHATASE TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG177413|UniProtKB=T1FBN1 T1FBN1 20206230 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED FMRFAMIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG185984|UniProtKB=T1FNI7 T1FNI7 20210384 PTHR11618:SF13 TRANSCRIPTION INITIATION FACTOR IIB-RELATED TRANSCRIPTION INITIATION FACTOR IIB cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;gene expression#GO:0010467;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;aromatic compound biosynthetic process#GO:0019438;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein-containing complex#GO:0032991;protein-DNA complex#GO:0032993 general transcription factor#PC00259 Transcription regulation by bZIP transcription factor#P00055>TFIIB#P01397;General transcription regulation#P00023>TFIIB#P00668 HELRO|EnsemblGenome=HelroG166201|UniProtKB=T1EXW5 T1EXW5 20201415 PTHR11929:SF145 ALPHA- 1,3 -FUCOSYLTRANSFERASE ALPHA-(1,3)-FUCOSYLTRANSFERASE FUT-1 transferase activity#GO:0016740;fucosyltransferase activity#GO:0008417;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycosylation#GO:0070085;metabolic process#GO:0008152 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG186765|UniProtKB=T1FP32 T1FP32 20210579 PTHR12058:SF0 ARP2/3 COMPLEX 34 KDA SUBUNIT ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2 cytoskeletal protein binding#GO:0008092;structural molecule activity#GO:0005198;binding#GO:0005488;actin filament binding#GO:0051015;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;structural constituent of cytoskeleton#GO:0005200;actin binding#GO:0003779 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;Arp2/3 complex-mediated actin nucleation#GO:0034314;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;Arp2/3 protein complex#GO:0005885;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 Integrin signalling pathway#P00034>Arp2/3#P00912;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Arp2/3#P00876;Cytoskeletal regulation by Rho GTPase#P00016>ARP2/3#P00511 HELRO|EnsemblGenome=HelroG73674|UniProtKB=T1G1H2 T1G1H2 20214920 PTHR46061:SF3 THYROTROPIN-RELEASING HORMONE RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 Thyrotropin-releasing hormone receptor signaling pathway#P04394>TRH Receptor#P04580 HELRO|EnsemblGenome=HelroG176480|UniProtKB=T1FAK1 T1FAK1 20205850 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG159597|UniProtKB=T1EP80 T1EP80 20198380 PTHR36170:SF1 CENTROSOMAL PROTEIN OF 89 KDA CENTROSOMAL PROTEIN OF 89 KDA organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;organelle organization#GO:0006996;mitochondrion organization#GO:0007005;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 microtubule organizing center#GO:0005815;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;centriole#GO:0005814;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ciliary transition fiber#GO:0097539;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG180894|UniProtKB=T1FGD7 T1FGD7 20207886 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG156955|UniProtKB=T1EM40 T1EM40 20197640 PTHR45732:SF7 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8 Huntington disease#P00029>ARF#P00786 HELRO|EnsemblGenome=HelroG172941|UniProtKB=T1F664 T1F664 20204313 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172548|UniProtKB=T1F5H9 T1F5H9 20204078 PTHR36193:SF24 PHISTB DOMAIN-CONTAINING RESA-LIKE PROTEIN 1 LIPASE MATURATION FACTOR HELRO|EnsemblGenome=HelroG170812|UniProtKB=T1F3G6 T1F3G6 20203365 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG85614|UniProtKB=T1G605 T1G605 20216502 PTHR24406:SF8 TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED FI01110P-RELATED nucleic acid binding#GO:0003676;protein-containing complex binding#GO:0044877;chromatin DNA binding#GO:0031490;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG188331|UniProtKB=T1FPW2 T1FPW2 20210859 PTHR23113:SF249 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6 nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;Ras protein signal transduction#GO:0007265;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052 plasma membrane region#GO:0098590;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;apical part of cell#GO:0045177;plasma membrane#GO:0005886;apical plasma membrane#GO:0016324 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG194575|UniProtKB=T1FW76 T1FW76 20213072 PTHR15160:SF1 VON HIPPEL-LINDAU PROTEIN VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Hypoxia response via HIF activation#P00030>VHL#P00816 HELRO|EnsemblGenome=HelroG111184|UniProtKB=T1EF92 T1EF92 20195244 PTHR14083:SF0 YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN YIP1D-INTERACTING FACTOR 1, ISOFORM C localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987 bounding membrane of organelle#GO:0098588;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;Golgi membrane#GO:0000139;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG175049|UniProtKB=T1F8S3 T1F8S3 20205222 PTHR23050:SF518 CALCIUM BINDING PROTEIN AT16150P-RELATED cation binding#GO:0043169;small molecule binding#GO:0036094;molecular function regulator activity#GO:0098772;binding#GO:0005488;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;enzyme regulator activity#GO:0030234 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061 B cell activation#P00010>Calmodulin#P00375;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Calmodulin#P00755;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716;T cell activation#P00053>Calmodulin#P01305 HELRO|EnsemblGenome=HelroG187446|UniProtKB=T1FP98 T1FP98 20210645 PTHR11024:SF3 NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER NUCLEOPORIN SEH1 positive regulation of signal transduction#GO:0009967;regulation of signaling#GO:0023051;response to extracellular stimulus#GO:0009991;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;positive regulation of response to stimulus#GO:0048584;cellular response to starvation#GO:0009267;positive regulation of TOR signaling#GO:0032008;regulation of signal transduction#GO:0009966;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;cellular response to extracellular stimulus#GO:0031668;regulation of cell communication#GO:0010646;positive regulation of TORC1 signaling#GO:1904263;cellular response to stimulus#GO:0051716;regulation of TORC1 signaling#GO:1903432;cell communication#GO:0007154;response to nutrient levels#GO:0031667;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to stress#GO:0006950;cellular response to nutrient levels#GO:0031669;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to starvation#GO:0042594;biological regulation#GO:0065007;cellular response to external stimulus#GO:0071496;cellular response to amino acid starvation#GO:0034198;cellular response to stress#GO:0033554 envelope#GO:0031975;nuclear pore#GO:0005643;protein-containing complex#GO:0032991;Seh1-associated complex#GO:0035859;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG194669|UniProtKB=T1FWA6 T1FWA6 20213102 PTHR16116:SF5 ZINC FINGER PROTEIN 839 ZINC FINGER PROTEIN 839 HELRO|EnsemblGenome=HelroG89986|UniProtKB=T1G7J9 T1G7J9 20217046 PTHR24056:SF246 CELL DIVISION PROTEIN KINASE ECDYSONE-INDUCED PROTEIN 63E, ISOFORM N cyclin-dependent protein kinase activity#GO:0097472;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG121903|UniProtKB=T1EGT1 T1EGT1 20195781 PTHR24241:SF117 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;binding#GO:0005488;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888;amide binding#GO:0033218 response to organic substance#GO:0010033;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;response to hormone#GO:0009725;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG168367|UniProtKB=T1F0H5 T1F0H5 20202325 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG78151|UniProtKB=T1G388 T1G388 20215536 PTHR24115:SF1016 KINESIN-RELATED KINESIN FAMILY MEMBER 19A pyrophosphatase activity#GO:0016462;cytoskeletal protein binding#GO:0008092;microtubule motor activity#GO:0003777;tubulin binding#GO:0015631;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;cytoskeletal motor activity#GO:0003774;microtubule binding#GO:0008017;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;microtubule associated complex#GO:0005875;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG63809|UniProtKB=T1FXK6 T1FXK6 20213554 PTHR12473:SF17 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-3 hydrolase activity#GO:0016787;ubiquitin-like protein peptidase activity#GO:0019783;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG165273|UniProtKB=T1EWJ0 T1EWJ0 20200940 PTHR15934:SF2 RNA 2',3'-CYCLIC PHOSPHODIESTERASE A-KINASE ANCHOR PROTEIN 7-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN protein kinase A binding#GO:0051018;protein kinase A regulatory subunit binding#GO:0034237;protein binding#GO:0005515;binding#GO:0005488 regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;regulation of signaling#GO:0023051;biological regulation#GO:0065007;regulation of intracellular signal transduction#GO:1902531 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG191387|UniProtKB=T1FSY2 T1FSY2 20211929 PTHR11093:SF6 RUVB-RELATED REPTIN AND PONTIN RUVB-LIKE 1 ATP-dependent activity, acting on DNA#GO:0008094;catalytic activity, acting on a nucleic acid#GO:0140640;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;protein-containing complex assembly#GO:0065003;regulation of RNA biosynthetic process#GO:2001141;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;protein-RNA complex assembly#GO:0022618;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;ribonucleoprotein complex biogenesis#GO:0022613;biological regulation#GO:0065007;chromatin organization#GO:0006325;protein-RNA complex organization#GO:0071826;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;NuA4 histone acetyltransferase complex#GO:0035267;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;chromosome#GO:0005694 HELRO|EnsemblGenome=HelroG169779|UniProtKB=T1F2B4 T1F2B4 20202964 PTHR19964:SF97 MULTIPLE PDZ DOMAIN PROTEIN PDZ DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG137972|UniProtKB=T1EIQ3 T1EIQ3 20196453 PTHR48019:SF134 SERUM RESPONSE FACTOR HOMOLOG SERUM RESPONSE FACTOR HOMOLOG sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 MADS box transcription factor#PC00250 PDGF signaling pathway#P00047>SRF#P01165 HELRO|EnsemblGenome=HelroG169436|UniProtKB=T1F1X7 T1F1X7 20202827 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185411|UniProtKB=T1FMS2 T1FMS2 20210121 PTHR10174:SF130 ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED ALPHA-TOCOPHEROL TRANSFER PROTEIN-LIKE phosphatidylinositol bisphosphate binding#GO:1902936;lipid binding#GO:0008289;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981;binding#GO:0005488 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG80911|UniProtKB=T1G471 T1G471 20215869 PTHR48013:SF31 DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;MAPK cascade#GO:0000165;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 EGF receptor signaling pathway#P00018>MEK1-2#P00559;Endothelin signaling pathway#P00019>MEK#P00572;FGF signaling pathway#P00021>MEK1-2#P00642;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>MEK#P00891;PDGF signaling pathway#P00047>MEK#P01162 HELRO|EnsemblGenome=HelroG137404|UniProtKB=T1EIK4 T1EIK4 20196404 PTHR24637:SF377 COLLAGEN COLLAGEN TYPE IX ALPHA 1 CHAIN HELRO|EnsemblGenome=HelroG68567|UniProtKB=T1FZG7 T1FZG7 20214215 PTHR43109:SF2 NUCLEOSIDE DIPHOSPHATE KINASE 7 NUCLEOSIDE DIPHOSPHATE KINASE 7 supramolecular complex#GO:0099080;axoneme#GO:0005930;cytoplasmic microtubule#GO:0005881;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;ciliary plasm#GO:0097014;plasma membrane bounded cell projection cytoplasm#GO:0032838;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929;microtubule#GO:0005874;axonemal microtubule#GO:0005879 transferase#PC00220;kinase#PC00137;metabolite interconversion enzyme#PC00262 De novo purine biosynthesis#P02738>dADP kinase#P02907;De novo purine biosynthesis#P02738>GDP kinase#P02891 HELRO|EnsemblGenome=HelroG168035|UniProtKB=T1F033 T1F033 20202183 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG107827|UniProtKB=T1EED0 T1EED0 20194932 PTHR18945:SF784 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 1 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;localization#GO:0051179;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 membrane protein complex#GO:0098796;synapse#GO:0045202;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron projection#GO:0043005;transmembrane transporter complex#GO:1902495;cell projection#GO:0042995;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 Nicotinic acetylcholine receptor signaling pathway#P00044>beta#P01095;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HELRO|EnsemblGenome=HelroG145054|UniProtKB=T1EJI3 T1EJI3 20196733 PTHR10071:SF281 TRANSCRIPTION FACTOR GATA FAMILY MEMBER BOX A-BINDING FACTOR-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of RNA metabolic process#GO:0051253;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of transcription by RNA polymerase II#GO:0000122;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;regulation of DNA-templated transcription#GO:0006355;negative regulation of metabolic process#GO:0009892;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;negative regulation of nitrogen compound metabolic process#GO:0051172;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG95818|UniProtKB=T1G978 T1G978 20217625 PTHR10615:SF82 HISTONE ACETYLTRANSFERASE HISTONE ACETYLTRANSFERASE KAT8 histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;protein-DNA complex#GO:0032993;chromatin#GO:0000785;catalytic complex#GO:1902494;NuA4 histone acetyltransferase complex#GO:0035267;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;chromosome#GO:0005694 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG83511|UniProtKB=T1G566 T1G566 20216214 PTHR43899:SF13 RH59310P RH59310P oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG168981|UniProtKB=T1F178 T1F178 20202578 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186250|UniProtKB=T1FNV3 T1FNV3 20210500 PTHR45991:SF1 PACHYTENE CHECKPOINT PROTEIN 2 PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG cellular aromatic compound metabolic process#GO:0006725;negative regulation of biological process#GO:0048519;signal transduction#GO:0007165;nuclear division#GO:0000280;cell cycle process#GO:0022402;regulation of cellular component organization#GO:0051128;negative regulation of cell cycle process#GO:0010948;negative regulation of nuclear division#GO:0051784;nucleobase-containing compound metabolic process#GO:0006139;reciprocal homologous recombination#GO:0140527;regulation of biological process#GO:0050789;cell cycle checkpoint signaling#GO:0000075;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;meiotic cell cycle process#GO:1903046;negative regulation of organelle organization#GO:0010639;meiosis I cell cycle process#GO:0061982;reciprocal meiotic recombination#GO:0007131;reproductive process#GO:0022414;intracellular signal transduction#GO:0035556;negative regulation of cellular component organization#GO:0051129;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;meiosis I#GO:0007127;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;regulation of nuclear division#GO:0051783;macromolecule metabolic process#GO:0043170;meiotic cell cycle#GO:0051321;negative regulation of cell cycle#GO:0045786;regulation of organelle organization#GO:0033043;regulation of cell cycle phase transition#GO:1901987;negative regulation of cell cycle phase transition#GO:1901988;cellular metabolic process#GO:0044237;cell communication#GO:0007154;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;regulation of cell cycle process#GO:0010564;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;reproduction#GO:0000003;regulation of meiotic cell cycle#GO:0051445;organelle organization#GO:0006996;meiotic nuclear division#GO:0140013;regulation of cellular process#GO:0050794;sexual reproduction#GO:0019953;biological regulation#GO:0065007;cell cycle#GO:0007049;organelle fission#GO:0048285;regulation of cell cycle#GO:0051726;homologous recombination#GO:0035825;DNA metabolic process#GO:0006259 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG161598|UniProtKB=T1ERP2 T1ERP2 20199242 PTHR12352:SF3 SECRETED MODULAR CALCIUM-BINDING PROTEIN NIDOGEN-2 extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG111769|UniProtKB=T1EFE3 T1EFE3 20195295 PTHR20963:SF8 MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE 1 hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG71783|UniProtKB=T1G0R7 T1G0R7 20214665 PTHR19970:SF0 RIBOSOMAL PROTEIN L39E LARGE RIBOSOMAL SUBUNIT PROTEIN EL39 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG68916|UniProtKB=T1FZL2 T1FZL2 20214260 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG68024|UniProtKB=T1FZ93 T1FZ93 20214141 PTHR46983:SF3 CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1 CHPADIPLOID STATE MAINTENANCE PROTEIN CHPA HELRO|EnsemblGenome=HelroG178558|UniProtKB=T1FDD6 T1FDD6 20206835 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG172362|UniProtKB=T1F583 T1F583 20203982 PTHR45775:SF6 RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C HELRO|EnsemblGenome=HelroG83602|UniProtKB=T1G581 T1G581 20216228 PTHR12297:SF3 HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED HIG1 DOMAIN FAMILY MEMBER 1A scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG166500|UniProtKB=T1EY65 T1EY65 20201515 PTHR12774:SF2 PEROXISOMAL BIOGENESIS FACTOR 19 PEROXISOMAL BIOGENESIS FACTOR 19 signal sequence binding#GO:0005048;binding#GO:0005488;amide binding#GO:0033218;peptide binding#GO:0042277 localization within membrane#GO:0051668;cellular localization#GO:0051641;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;transport#GO:0006810;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;cellular component organization#GO:0016043;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to membrane#GO:0090150;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;organelle organization#GO:0006996;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365;peroxisome organization#GO:0007031 bounding membrane of organelle#GO:0098588;peroxisomal membrane#GO:0005778;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;peroxisome#GO:0005777;microbody#GO:0042579;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG68925|UniProtKB=T1FZL8 T1FZL8 20214266 PTHR12651:SF1 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9 protein-containing complex assembly#GO:0065003;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cellular process#GO:0009987;protein-containing complex organization#GO:0043933 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protease#PC00190 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG144193|UniProtKB=T1EJD8 T1EJD8 20196688 PTHR13058:SF22 THREE PRIME REPAIR EXONUCLEASE 1, 2 EXODEOXYRIBONUCLEASE III hydrolase activity, acting on ester bonds#GO:0016788;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;3'-5'-DNA exonuclease activity#GO:0008296;nuclease activity#GO:0004518;DNA exonuclease activity#GO:0004529;catalytic activity#GO:0003824;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097;exonuclease activity#GO:0004527;3'-5' exonuclease activity#GO:0008408 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;heterocycle catabolic process#GO:0046700;macromolecule metabolic process#GO:0043170;DNA catabolic process#GO:0006308;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular nitrogen compound catabolic process#GO:0044270;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic cyclic compound catabolic process#GO:1901361;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;nucleobase-containing compound catabolic process#GO:0034655;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;cellular catabolic process#GO:0044248 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG173282|UniProtKB=T1F6M7 T1F6M7 20204476 PTHR16021:SF18 MANSC DOMAIN CONTAINING PROTEIN 1 GROUP-SPECIFIC ANTIGEN HELRO|EnsemblGenome=HelroG63866|UniProtKB=T1FXL3 T1FXL3 20213561 PTHR11909:SF20 CASEIN KINASE-RELATED CASEIN KINASE I ISOFORM ALPHA transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Hedgehog signaling pathway#P00025>Casein kinase I#P00681;Parkinson disease#P00049>Casein kinase I#P01242 HELRO|EnsemblGenome=HelroG68856|UniProtKB=T1FZK4 T1FZK4 20214252 PTHR43782:SF3 ARGINASE ARGINASE cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;hydrolase activity#GO:0016787;metal ion binding#GO:0046872;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;ion binding#GO:0043167 oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;arginine metabolic process#GO:0006525;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;amino acid catabolic process#GO:0009063;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;nitrogen compound metabolic process#GO:0006807;alpha-amino acid metabolic process#GO:1901605;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG153255|UniProtKB=T1EL19 T1EL19 20197269 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG98326|UniProtKB=T1G9M0 T1G9M0 20217766 PTHR13906:SF12 PORCUPINE PROTEIN-SERINE O-PALMITOLEOYLTRANSFERASE PORCUPINE protein binding#GO:0005515;transferase activity#GO:0016740;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;Wnt-protein binding#GO:0017147;binding#GO:0005488;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;cellular localization#GO:0051641;macromolecule localization#GO:0033036;macromolecule modification#GO:0043412;transport#GO:0006810;nitrogen compound transport#GO:0071705;protein modification process#GO:0036211;protein secretion#GO:0009306;lipid modification#GO:0030258;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;regulation of biological process#GO:0050789;organic substance transport#GO:0071702;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;secretion#GO:0046903;signal release#GO:0023061;protein palmitoylation#GO:0018345;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;cell-cell signaling#GO:0007267;signaling#GO:0023052;organic substance metabolic process#GO:0071704;secretion by cell#GO:0032940;metabolic process#GO:0008152;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;protein acylation#GO:0043543;cell-cell signaling by wnt#GO:0198738;cellular process#GO:0009987;lipoprotein biosynthetic process#GO:0042158;primary metabolic process#GO:0044238;protein localization#GO:0008104;localization#GO:0051179;establishment of protein localization to extracellular region#GO:0035592;cellular macromolecule localization#GO:0070727;protein transport#GO:0015031;biological regulation#GO:0065007;lipoprotein metabolic process#GO:0042157;cellular lipid metabolic process#GO:0044255;protein localization to extracellular region#GO:0071692;export from cell#GO:0140352 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 acetyltransferase#PC00038;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG185946|UniProtKB=T1FNG9 T1FNG9 20210366 PTHR11431:SF75 FERRITIN FERRITIN cation binding#GO:0043169;ferrous iron binding#GO:0008198;small molecule binding#GO:0036094;binding#GO:0005488;iron ion binding#GO:0005506;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;ion binding#GO:0043167 localization#GO:0051179;inorganic ion homeostasis#GO:0098771;cellular localization#GO:0051641;intracellular iron ion homeostasis#GO:0006879;maintenance of location#GO:0051235;maintenance of location in cell#GO:0051651;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;chemical homeostasis#GO:0048878;cellular process#GO:0009987;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 storage protein#PC00210 HELRO|EnsemblGenome=HelroG163710|UniProtKB=T1EUD9 T1EUD9 20200189 PTHR13255:SF0 ATAXIN-10 ATAXIN-10 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG78563|UniProtKB=T1G3D0 T1G3D0 20215578 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;heme binding#GO:0020037 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG171551|UniProtKB=T1F4E5 T1F4E5 20203694 PTHR23220:SF122 INTEGRIN ALPHA INTEGRIN ALPHA-PS1 cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;integrin binding#GO:0005178;binding#GO:0005488;signaling receptor binding#GO:0005102 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;cell adhesion mediated by integrin#GO:0033627;cell-cell adhesion#GO:0098609;cell communication#GO:0007154;cell adhesion#GO:0007155;cell-substrate adhesion#GO:0031589;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cell-matrix adhesion#GO:0007160;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;integrin-mediated signaling pathway#GO:0007229;biological regulation#GO:0065007;signaling#GO:0023052 receptor complex#GO:0043235;membrane protein complex#GO:0098796;external side of plasma membrane#GO:0009897;cell surface#GO:0009986;protein-containing complex#GO:0032991;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;side of membrane#GO:0098552;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;integrin#PC00126 Integrin signalling pathway#P00034>Integrin alpha#P00941 HELRO|EnsemblGenome=HelroG112997|UniProtKB=T1EFP4 T1EFP4 20195396 PTHR21506:SF0 COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;Golgi vesicle transport#GO:0048193;intra-Golgi vesicle-mediated transport#GO:0006891;transport#GO:0006810 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;vesicle tethering complex#GO:0099023;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;Golgi transport complex#GO:0017119;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG175155|UniProtKB=T1F8X5 T1F8X5 20205274 PTHR46630:SF1 TETRATRICOPEPTIDE REPEAT PROTEIN 29 TETRATRICOPEPTIDE REPEAT PROTEIN 29 HELRO|EnsemblGenome=HelroG181634|UniProtKB=T1FH70 T1FH70 20208169 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193509|UniProtKB=T1FV25 T1FV25 20212671 PTHR11533:SF299 PROTEASE M1 ZINC METALLOPROTEASE AMINOPEPTIDASE metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;amide binding#GO:0033218;metal ion binding#GO:0046872;peptidase activity#GO:0008233;metalloaminopeptidase activity#GO:0070006;cation binding#GO:0043169;peptide binding#GO:0042277;hydrolase activity#GO:0016787;aminopeptidase activity#GO:0004177;exopeptidase activity#GO:0008238;ion binding#GO:0043167;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;peptide catabolic process#GO:0043171;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;membrane#GO:0016020;extracellular region#GO:0005576;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG156658|UniProtKB=T1ELZ5 T1ELZ5 20197595 PTHR11530:SF11 D-AMINO ACID OXIDASE D-ASPARTATE OXIDASE oxidase#PC00175;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG160668|UniProtKB=T1EQK9 T1EQK9 20198859 PTHR31551:SF1 PRE-MRNA-SPLICING FACTOR CWF18 COILED-COIL DOMAIN-CONTAINING PROTEIN 12 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;U2-type spliceosomal complex#GO:0005684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;post-mRNA release spliceosomal complex#GO:0071014;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG177142|UniProtKB=T1FB96 T1FB96 20206095 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG85402|UniProtKB=T1G5W5 T1G5W5 20216462 PTHR13345:SF13 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG164778|UniProtKB=T1EVS9 T1EVS9 20200679 PTHR45624:SF24 MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN G transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;transport#GO:0006810 transporter#PC00227 HELRO|EnsemblGenome=HelroG157317|UniProtKB=T1EM95 T1EM95 20197695 PTHR10183:SF433 CALPAIN CALPAIN-A-RELATED cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protease#PC00190 Huntington disease#P00029>Calpain#P00788 HELRO|EnsemblGenome=HelroG171655|UniProtKB=T1F4I8 T1F4I8 20203737 PTHR15367:SF2 DNA-DIRECTED RNA POLYMERASE III DNA-DIRECTED RNA POLYMERASE III SUBUNIT nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;nuclear DNA-directed RNA polymerase complex#GO:0055029;RNA polymerase III complex#GO:0005666;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG166266|UniProtKB=T1EXY6 T1EXY6 20201436 PTHR24104:SF57 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED BEE-MILK PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG107104|UniProtKB=T1EE75 T1EE75 20194877 PTHR22781:SF12 DELTA ADAPTIN-RELATED AP-3 COMPLEX SUBUNIT DELTA-1 cellular localization#GO:0051641;establishment of protein localization to vacuole#GO:0072666;macromolecule localization#GO:0033036;protein targeting to vacuole#GO:0006623;vacuolar transport#GO:0007034;post-Golgi vesicle-mediated transport#GO:0006892;transport#GO:0006810;protein localization to vacuole#GO:0072665;protein targeting#GO:0006605;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;Golgi to vacuole transport#GO:0006896;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endosome membrane#GO:0010008;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;AP-type membrane coat adaptor complex#GO:0030119;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane coat#GO:0030117;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;coated membrane#GO:0048475;cytoplasmic vesicle membrane#GO:0030659 transporter#PC00227 HELRO|EnsemblGenome=HelroG165143|UniProtKB=T1EWC3 T1EWC3 20200873 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG90788|UniProtKB=T1G7W4 T1G7W4 20217161 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG82785|UniProtKB=T1G4W6 T1G4W6 20216114 PTHR19961:SF18 FIMBRIN/PLASTIN FI19014P1 cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament bundle assembly#GO:0051017;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;actin filament bundle organization#GO:0061572;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;actin filament bundle#GO:0032432;actin cytoskeleton#GO:0015629;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;actin filament#GO:0005884;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG178415|UniProtKB=T1FD50 T1FD50 20206749 PTHR10075:SF100 BASIGIN RELATED FASCICLIN-2 cell adhesion molecule binding#GO:0050839;cell-cell adhesion mediator activity#GO:0098632;protein binding#GO:0005515;binding#GO:0005488 neuron projection guidance#GO:0097485;cell recognition#GO:0008037;neurogenesis#GO:0022008;cell projection organization#GO:0030030;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;axonogenesis#GO:0007409;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156;cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cell morphogenesis#GO:0000902;cellular process#GO:0009987;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure development#GO:0048856;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;axon#GO:0030424 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG182539|UniProtKB=T1FIC0 T1FIC0 20208569 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG83644|UniProtKB=T1G586 T1G586 20216233 PTHR46010:SF1 PROTEIN IWS1 HOMOLOG PROTEIN IWS1 HOMOLOG poly(A)+ mRNA export from nucleus#GO:0016973;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;mRNA transport#GO:0051028;RNA localization#GO:0006403;localization#GO:0051179;organic substance transport#GO:0071702;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG190317|UniProtKB=T1FRW5 T1FRW5 20211562 PTHR14949:SF54 EGF-LIKE-DOMAIN, MULTIPLE 7, 8 VWFD DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 anatomical structure development#GO:0048856;developmental process#GO:0032502 cell surface#GO:0009986;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG175447|UniProtKB=T1F996 T1F996 20205395 PTHR15065:SF4 INSULINOMA-ASSOCIATED 1 LD18634P HELRO|EnsemblGenome=HelroG183449|UniProtKB=T1FJP2 T1FJP2 20209041 PTHR45659:SF4 HOMEOBOX PROTEIN HOX HOMEOBOX PROTEIN ABDOMINAL-A sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regionalization#GO:0003002;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;anterior/posterior pattern specification#GO:0009952;multicellular organismal process#GO:0032501;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;pattern specification process#GO:0007389;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG171005|UniProtKB=T1F3P4 T1F3P4 20203443 PTHR45627:SF1 ADENYLATE CYCLASE TYPE 1 ADENYLATE CYCLASE TYPE 8 adenylate cyclase activity#GO:0004016;lyase activity#GO:0016829;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cyclase#PC00079;adenylate cyclase#PC00043;lyase#PC00144 Endothelin signaling pathway#P00019>Adenylate cyclase#P00569;GABA-B receptor II signaling#P05731>AC#P05760;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>cAMP cyclase#P00719 HELRO|EnsemblGenome=HelroG112394|UniProtKB=T1EFJ5 T1EFJ5 20195347 PTHR11960:SF8 EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED nucleic acid binding#GO:0003676;RNA binding#GO:0003723;translation regulator activity#GO:0045182;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation initiation factor activity#GO:0003743;RNA cap binding#GO:0000339;translation regulator activity, nucleic acid binding#GO:0090079;translation factor activity, RNA binding#GO:0008135 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;translational initiation#GO:0006413;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG190274|UniProtKB=T1FRU7 T1FRU7 20211544 PTHR46569:SF1 E3 UBIQUITIN-PROTEIN LIGASE TRAIP E3 UBIQUITIN-PROTEIN LIGASE RFWD3-RELATED transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;post-translational protein modification#GO:0043687;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;DNA-templated DNA replication#GO:0006261;replication fork processing#GO:0031297;DNA replication#GO:0006260;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;site of DNA damage#GO:0090734;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG155987|UniProtKB=T1ELQ5 T1ELQ5 20197505 PTHR24343:SF466 SERINE/THREONINE KINASE AMP-ACTIVATED PROTEIN KINASE ALPHA SUBUNIT, ISOFORM A transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG173533|UniProtKB=T1F6Y3 T1F6Y3 20204582 PTHR12419:SF7 OTU DOMAIN CONTAINING PROTEIN OTU DOMAIN-CONTAINING PROTEIN 3 cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG164925|UniProtKB=T1EVZ2 T1EVZ2 20200742 PTHR24410:SF41 HL07962P-RELATED HL07962P defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG189679|UniProtKB=T1FR91 T1FR91 20211338 PTHR11564:SF5 SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54 SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG157830|UniProtKB=T1EMG5 T1EMG5 20197765 PTHR13007:SF19 PRE-MRNA SPLICING FACTOR-RELATED PRE-MRNA-SPLICING FACTOR 18 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;mRNA splicing, via spliceosome#GO:0000398;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;U4/U6 x U5 tri-snRNP complex#GO:0046540;U2-type spliceosomal complex#GO:0005684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;U5 snRNP#GO:0005682;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;spliceosomal tri-snRNP complex#GO:0097526;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG144735|UniProtKB=T1EJG1 T1EJG1 20196711 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG177006|UniProtKB=T1FB47 T1FB47 20206046 PTHR15907:SF182 DUF614 FAMILY PROTEIN-RELATED PROTEIN PLANT CADMIUM RESISTANCE 1-RELATED HELRO|EnsemblGenome=HelroG177730|UniProtKB=T1FC53 T1FC53 20206402 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178870|UniProtKB=T1FDU5 T1FDU5 20206994 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG105068|UniProtKB=T1EDQ4 T1EDQ4 20194706 PTHR24409:SF295 ZINC FINGER PROTEIN 142 AZ2-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG169709|UniProtKB=T1F292 T1F292 20202942 PTHR44927:SF1 FK506-BINDING PROTEIN 15 FK506-BINDING PROTEIN 15 HELRO|EnsemblGenome=HelroG148261|UniProtKB=T1EK63 T1EK63 20196963 PTHR12547:SF174 CCCH ZINC FINGER/TIS11-RELATED MRNA DECAY ACTIVATOR PROTEIN ZFP36L2 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG122869|UniProtKB=T1EGW2 T1EGW2 20195812 PTHR24228:SF74 B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG168053|UniProtKB=T1F041 T1F041 20202191 PTHR46601:SF1 ULP_PROTEASE DOMAIN-CONTAINING PROTEIN ADF-H DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG115988|UniProtKB=T1EGC4 T1EGC4 20195626 PTHR10693:SF20 RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN AT27578P nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;cytosol#GO:0005829;protein-containing complex#GO:0032991;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG181730|UniProtKB=T1FH95 T1FH95 20208194 PTHR23033:SF14 BETA1,3-GALACTOSYLTRANSFERASE GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED galactosyltransferase activity#GO:0008378;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG193240|UniProtKB=T1FUS3 T1FUS3 20212569 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185601|UniProtKB=T1FN09 T1FN09 20210208 PTHR45625:SF1 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;peptidyl-prolyl cis-trans isomerase activity#GO:0003755;aminoacyltransferase activity#GO:0016755;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein peptidyl-prolyl isomerization#GO:0000413;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;catalytic step 2 spliceosome#GO:0071013;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG166585|UniProtKB=T1EYA0 T1EYA0 20201550 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG174825|UniProtKB=T1G4I0 T1G4I0 20215978 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG164796|UniProtKB=T1EVT5 T1EVT5 20200685 PTHR13402:SF6 RGPR-RELATED SECRETORY 16, ISOFORM I localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;protein localization to endoplasmic reticulum#GO:0070972;Golgi organization#GO:0007030;macromolecule localization#GO:0033036;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;cellular component organization#GO:0016043;protein localization to organelle#GO:0033365;cellular process#GO:0009987;protein localization#GO:0008104 bounding membrane of organelle#GO:0098588;ER to Golgi transport vesicle membrane#GO:0012507;endoplasmic reticulum exit site#GO:0070971;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;coated vesicle membrane#GO:0030662;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;cytoplasmic vesicle membrane#GO:0030659;endoplasmic reticulum#GO:0005783 HELRO|EnsemblGenome=HelroG90499|UniProtKB=T1G7S3 T1G7S3 20217120 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174887|UniProtKB=T1F8K8 T1F8K8 20205157 PTHR24067:SF3 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 G1 ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E2#P01491 HELRO|EnsemblGenome=HelroG93606|UniProtKB=T1G8W8 T1G8W8 20217515 PTHR24356:SF184 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE TRICORNERED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG182523|UniProtKB=T1FIB4 T1FIB4 20208563 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159076|UniProtKB=T1ENK1 T1ENK1 20198151 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162245|UniProtKB=T1ESE4 T1ESE4 20199494 PTHR11685:SF371 RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE RNF14 ubiquitin-like protein conjugating enzyme binding#GO:0044390;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;enzyme binding#GO:0019899;protein binding#GO:0005515;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG170631|UniProtKB=T1F395 T1F395 20203294 PTHR11803:SF39 2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA 2-IMINOBUTANOATE_2-IMINOPROPANOATE DEAMINASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;deaminase activity#GO:0019239;catalytic activity#GO:0003824 organonitrogen compound metabolic process#GO:1901564;catabolic process#GO:0009056;organonitrogen compound catabolic process#GO:1901565;organic substance catabolic process#GO:1901575;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 deaminase#PC00088;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG165611|UniProtKB=T1EX28 T1EX28 20201128 PTHR10574:SF440 NETRIN/LAMININ-RELATED LAMININ EGF-LIKE DOMAIN-CONTAINING PROTEIN cellular developmental process#GO:0048869;neurogenesis#GO:0022008;cell projection organization#GO:0030030;animal organ development#GO:0048513;developmental process#GO:0032502;multicellular organism development#GO:0007275;cell morphogenesis#GO:0000902;cell projection morphogenesis#GO:0048858;cellular component organization#GO:0016043;nervous system development#GO:0007399;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;tissue development#GO:0009888;cellular anatomical entity morphogenesis#GO:0032989;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;system development#GO:0048731;cell differentiation#GO:0030154;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;animal organ morphogenesis#GO:0009887;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;neuron projection morphogenesis#GO:0048812;neuron development#GO:0048666;generation of neurons#GO:0048699;plasma membrane bounded cell projection morphogenesis#GO:0120039;axonogenesis#GO:0007409 extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG185981|UniProtKB=T1FNI5 T1FNI5 20210382 PTHR19957:SF3 SYNTAXIN SYNTAXIN-5 molecular adaptor activity#GO:0060090;protein binding#GO:0005515;SNAP receptor activity#GO:0005484;binding#GO:0005488;SNARE binding#GO:0000149;protein-macromolecule adaptor activity#GO:0030674 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;vesicle fusion#GO:0006906;cellular localization#GO:0051641;organelle localization#GO:0051640;macromolecule localization#GO:0033036;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;membrane fusion#GO:0061025;establishment of localization#GO:0051234;organelle organization#GO:0006996;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;vesicle organization#GO:0016050;intracellular transport#GO:0046907;organelle fusion#GO:0048284 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;SNARE complex#GO:0031201;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;Golgi membrane#GO:0000139 SNARE protein#PC00034;membrane traffic protein#PC00150 Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079 HELRO|EnsemblGenome=HelroG73506|UniProtKB=T1G1E9 T1G1E9 20214897 PTHR24366:SF170 IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS RE50361P cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG158226|UniProtKB=T1EMK8 T1EMK8 20197808 PTHR23043:SF36 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA PROTEIN SINGLE-MINDED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG75143|UniProtKB=T1G213 T1G213 20215111 PTHR24412:SF450 KELCH PROTEIN KELCH-LIKE PROTEIN DIABLO scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG80158|UniProtKB=T1G3Y4 T1G3Y4 20215782 PTHR11266:SF17 PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17 PROTEIN MPV17 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG92922|UniProtKB=T1G8N8 T1G8N8 20217435 PTHR10032:SF271 ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS RH12261P-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG72627|UniProtKB=T1G128 T1G128 20214776 PTHR22906:SF53 PROPERDIN HEMICENTIN-1 HELRO|EnsemblGenome=HelroG90258|UniProtKB=T1G7N5 T1G7N5 20217082 PTHR31501:SF7 CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1 CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG121890|UniProtKB=T1EGT0 T1EGT0 20195780 PTHR43876:SF7 UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG169995|UniProtKB=T1F2I3 T1F2I3 20203033 PTHR46007:SF8 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 C2H2-TYPE DOMAIN-CONTAINING PROTEIN molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;protein binding#GO:0005515;transcription factor binding#GO:0008134 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG180360|UniProtKB=T1FFT8 T1FFT8 20207687 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG162808|UniProtKB=T1ET70 T1ET70 20199770 PTHR19143:SF185 FIBRINOGEN/TENASCIN/ANGIOPOEITIN ANGIOPOIETIN-RELATED PROTEIN 5 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG96384|UniProtKB=T1G9B7 T1G9B7 20217664 PTHR11614:SF87 PHOSPHOLIPASE-RELATED MONOGLYCERIDE LIPASE hydrolase activity#GO:0016787;lipase activity#GO:0016298;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 cellular anatomical entity#GO:0110165;membrane#GO:0016020 phospholipase#PC00186;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG186309|UniProtKB=T1FNY2 T1FNY2 20210529 PTHR11071:SF547 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;catalytic activity#GO:0003824;amide binding#GO:0033218;peptide binding#GO:0042277 macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein peptidyl-prolyl isomerization#GO:0000413;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;protein modification process#GO:0036211;gene expression#GO:0010467;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein folding#GO:0006457;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG71280|UniProtKB=T1G0I9 T1G0I9 20214587 PTHR24082:SF283 NUCLEAR HORMONE RECEPTOR NUCLEAR HORMONE RECEPTOR HR96 cis-regulatory region sequence-specific DNA binding#GO:0000987;signaling receptor activity#GO:0038023;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of RNA metabolic process#GO:0051253;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of transcription by RNA polymerase II#GO:0000122;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;cellular developmental process#GO:0048869;negative regulation of biosynthetic process#GO:0009890;regulation of DNA-templated transcription#GO:0006355;negative regulation of metabolic process#GO:0009892;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;negative regulation of nitrogen compound metabolic process#GO:0051172;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG110518|UniProtKB=T1EF30 T1EF30 20195182 PTHR43381:SF20 TRANSLATION INITIATION FACTOR IF-2-RELATED TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL nucleic acid binding#GO:0003676;translation regulator activity#GO:0045182;translation regulator activity, nucleic acid binding#GO:0090079;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation initiation factor activity#GO:0003743;translation factor activity, RNA binding#GO:0008135 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;translational initiation#GO:0006413;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG178809|UniProtKB=T1FDR8 T1FDR8 20206967 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG171094|UniProtKB=T1F3T0 T1F3T0 20203479 PTHR31233:SF6 BICAUDAL D FAMILY MEMBER PROTEIN BICAUDAL D cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;dynein complex binding#GO:0070840 regulation of microtubule-based process#GO:0032886;cellular localization#GO:0051641;macromolecule localization#GO:0033036;regulation of organelle organization#GO:0033043;microtubule cytoskeleton organization#GO:0000226;regulation of cellular component organization#GO:0051128;cellular component organization#GO:0016043;cellular process#GO:0009987;protein localization#GO:0008104;localization#GO:0051179;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cytoskeleton organization#GO:0051493;cellular macromolecule localization#GO:0070727;microtubule-based process#GO:0007017;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;regulation of microtubule cytoskeleton organization#GO:0070507;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;protein localization to organelle#GO:0033365 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG177501|UniProtKB=T1FBT3 T1FBT3 20206282 PTHR47577:SF2 THAP DOMAIN-CONTAINING PROTEIN 6 THAP DOMAIN CONTAINING 9 HELRO|EnsemblGenome=HelroG181470|UniProtKB=T1FH13 T1FH13 20208112 PTHR10019:SF13 SNF5 PB1 DOMAIN-CONTAINING PROTEIN-RELATED molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 protein-DNA complex organization#GO:0071824;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;cellular component organization#GO:0016043;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG90436|UniProtKB=T1G7R3 T1G7R3 20217110 PTHR11374:SF3 UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE UDP-GLUCOSE 6-DEHYDROGENASE dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG114451|UniProtKB=T1EG19 T1EG19 20195521 PTHR12428:SF66 OXA1 MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L localization within membrane#GO:0051668;cellular localization#GO:0051641;macromolecule localization#GO:0033036;membrane organization#GO:0061024;protein localization to membrane#GO:0072657;establishment of protein localization to organelle#GO:0072594;cellular component organization#GO:0016043;protein localization to mitochondrion#GO:0070585;cellular process#GO:0009987;establishment of protein localization#GO:0045184;inner mitochondrial membrane organization#GO:0007007;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to membrane#GO:0090150;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;establishment of protein localization to mitochondrion#GO:0072655;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;protein localization to organelle#GO:0033365;mitochondrion organization#GO:0007005;mitochondrial membrane organization#GO:0007006;protein insertion into membrane#GO:0051205 envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;organelle inner membrane#GO:0019866;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227 transporter#PC00227 HELRO|EnsemblGenome=HelroG185843|UniProtKB=T1FNC9 T1FNC9 20210326 PTHR12411:SF586 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN L-LIKE cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197 macromolecule catabolic process#GO:0009057;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;proteolysis#GO:0006508;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;catabolic process#GO:0009056;organonitrogen compound catabolic process#GO:1901565;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;lysosome#GO:0005764;intracellular membrane-bounded organelle#GO:0043231;extracellular region#GO:0005576;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;organelle#GO:0043226;lytic vacuole#GO:0000323;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG90377|UniProtKB=T1G7Q3 T1G7Q3 20217100 PTHR11654:SF509 OLIGOPEPTIDE TRANSPORTER-RELATED SOLUTE CARRIER FAMILY 15 MEMBER 4 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG106870|UniProtKB=T1EE54 T1EE54 20194856 PTHR23050:SF510 CALCIUM BINDING PROTEIN CALMODULIN-LIKE PROTEIN 3 cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Calmodulin#P00755 HELRO|EnsemblGenome=HelroG71575|UniProtKB=T1G0N7 T1G0N7 20214635 PTHR23048:SF0 MYOSIN LIGHT CHAIN 1, 3 CALMODULIN LIKE 3 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;myosin complex#GO:0016459;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG191234|UniProtKB=T1FSR8 T1FSR8 20211865 PTHR45740:SF2 POLY [ADP-RIBOSE] POLYMERASE POLY [ADP-RIBOSE] POLYMERASE transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;pentosyltransferase activity#GO:0016763 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG192597|UniProtKB=T1FU42 T1FU42 20212338 PTHR13190:SF1 AUTOPHAGY-RELATED 2, ISOFORM A AUTOPHAGY-RELATED 2, ISOFORM A phosphatidylinositol-3-phosphate binding#GO:0032266;molecular adaptor activity#GO:0060090;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;protein-membrane adaptor activity#GO:0043495;lipid binding#GO:0008289;phosphatidylinositol binding#GO:0035091;phosphatidylinositol phosphate binding#GO:1901981;phospholipid binding#GO:0005543 cellular component assembly#GO:0022607;microautophagy#GO:0016237;cellular component biogenesis#GO:0044085;macroautophagy#GO:0016236;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;autophagy of mitochondrion#GO:0000422;cellular process#GO:0009987;organelle disassembly#GO:1903008;organelle assembly#GO:0070925;process utilizing autophagic mechanism#GO:0061919;cellular component organization or biogenesis#GO:0071840;reticulophagy#GO:0061709;vacuole organization#GO:0007033;cellular component disassembly#GO:0022411;organelle organization#GO:0006996;autophagosome assembly#GO:0000045;catabolic process#GO:0009056;mitochondrion organization#GO:0007005;autophagy#GO:0006914;piecemeal microautophagy of the nucleus#GO:0034727;metabolic process#GO:0008152;cellular catabolic process#GO:0044248 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;phagophore assembly site#GO:0000407;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG67796|UniProtKB=T1FZ54 T1FZ54 20214102 PTHR13844:SF7 SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D BRAHMA-ASSOCIATED PROTEIN OF 60 KDA regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;ATPase complex#GO:1904949;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;SWI/SNF complex#GO:0016514;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG184362|UniProtKB=T1FL19 T1FL19 20209518 PTHR46880:SF5 RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG116221|UniProtKB=T1EGD5 T1EGD5 20195637 PTHR11076:SF33 DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER DNA POLYMERASE KAPPA DNA-directed DNA polymerase activity#GO:0003887;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on DNA#GO:0140097;DNA polymerase activity#GO:0034061 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;postreplication repair#GO:0006301;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;translesion synthesis#GO:0019985;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;nucleobase-containing compound biosynthetic process#GO:0034654;DNA biosynthetic process#GO:0071897;DNA synthesis involved in DNA repair#GO:0000731;aromatic compound biosynthetic process#GO:0019438;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG105295|UniProtKB=T1EDT4 T1EDT4 20194736 PTHR32546:SF26 G-PROTEIN COUPLED RECEPTOR 158-RELATED SMOG, ISOFORM D G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG194101|UniProtKB=T1FVN9 T1FVN9 20212885 PTHR21284:SF12 EG:80H7.2 PROTEIN EG:80H7.2 PROTEIN HELRO|EnsemblGenome=HelroG163640|UniProtKB=T1EUA8 T1EUA8 20200158 PTHR19282:SF534 TETRASPANIN TETRASPANIN FAMILY-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG91534|UniProtKB=T1G851 T1G851 20217248 PTHR10663:SF342 GUANYL-NUCLEOTIDE EXCHANGE FACTOR FI21420P1 cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;organelle organization#GO:0006996 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG70906|UniProtKB=T1G0E1 T1G0E1 20214539 PTHR11011:SF45 MALE STERILITY PROTEIN 2-RELATED FATTY ACYL-COA REDUCTASE CG8306-RELATED oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;lipid metabolic process#GO:0006629;heterocycle metabolic process#GO:0046483;carbohydrate derivative metabolic process#GO:1901135;sulfur compound metabolic process#GO:0006790;acyl-CoA metabolic process#GO:0006637;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;amide metabolic process#GO:0043603;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;nucleobase-containing small molecule metabolic process#GO:0055086 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG153518|UniProtKB=T1EL85 T1EL85 20197335 PTHR23349:SF63 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST FER3-LIKE PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG179578|UniProtKB=T1FEW5 T1FEW5 20207364 PTHR14096:SF28 APOLIPOPROTEIN L APOLIPOPROTEIN L, 1-RELATED lipid binding#GO:0008289;binding#GO:0005488 cellular anatomical entity#GO:0110165;membrane#GO:0016020 apolipoprotein#PC00052 HELRO|EnsemblGenome=HelroG88795|UniProtKB=T1G766 T1G766 20216913 PTHR10293:SF16 GLUTAREDOXIN FAMILY MEMBER GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL reductase#PC00198;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG161743|UniProtKB=T1ERV3 T1ERV3 20199303 PTHR12766:SF7 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DEATH DOMAIN-ASSOCIATED PROTEIN 6 FAS signaling pathway#P00020>DAXX#P00602;Apoptosis signaling pathway#P00006>DAXX#P00296 HELRO|EnsemblGenome=HelroG191307|UniProtKB=T1FSV3 T1FSV3 20211900 PTHR24023:SF1112 COLLAGEN ALPHA COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN-RELATED structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922 HELRO|EnsemblGenome=HelroG172940|UniProtKB=T1F663 T1F663 20204312 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG194928|UniProtKB=T1FWK8 T1FWK8 20213203 PTHR37283:SF1 PH DOMAIN-CONTAINING PROTEIN YHR131C PH DOMAIN-CONTAINING PROTEIN YHR131C HELRO|EnsemblGenome=HelroG95960|UniProtKB=T1G992 T1G992 20217639 PTHR24408:SF58 ZINC FINGER PROTEIN TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG191057|UniProtKB=T1FSJ7 T1FSJ7 20211794 PTHR31061:SF24 LD22376P LD22376P HELRO|EnsemblGenome=HelroG191919|UniProtKB=T1FTF0 T1FTF0 20212097 PTHR33562:SF31 ATILLA, ISOFORM B-RELATED-RELATED PROTEIN QUIVER HELRO|EnsemblGenome=HelroG84668|UniProtKB=T1G5L6 T1G5L6 20216363 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;chloride transmembrane transporter activity#GO:0015108;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;inorganic anion transmembrane transport#GO:0098661;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic anion transport#GO:0006820;chloride transport#GO:0006821;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;inorganic anion transport#GO:0015698 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG175687|UniProtKB=T1F9J1 T1F9J1 20205490 PTHR42264:SF3 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN F-BOX DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG110801|UniProtKB=T1EF52 T1EF52 20195204 PTHR11849:SF195 ETS GA-BINDING PROTEIN ALPHA CHAIN transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 PDGF signaling pathway#P00047>Ets#P01167 HELRO|EnsemblGenome=HelroG174389|UniProtKB=T1F827 T1F827 20204976 PTHR47577:SF2 THAP DOMAIN-CONTAINING PROTEIN 6 THAP DOMAIN CONTAINING 9 HELRO|EnsemblGenome=HelroG163508|UniProtKB=T1EU54 T1EU54 20200104 PTHR45828:SF36 CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE REELIN DOMAIN-CONTAINING PROTEIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 reductase#PC00198;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG177007|UniProtKB=T1FB48 T1FB48 20206047 PTHR11066:SF34 ACYL-COA THIOESTERASE ACYL-COENZYME A THIOESTERASE 8 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;fatty acyl-CoA hydrolase activity#GO:0047617;catalytic activity#GO:0003824;thiolester hydrolase activity#GO:0016790 cellular aromatic compound metabolic process#GO:0006725;lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;sulfur compound metabolic process#GO:0006790;lipid catabolic process#GO:0016042;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;cellular lipid catabolic process#GO:0044242;amide metabolic process#GO:0043603;purine nucleotide metabolic process#GO:0006163;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248;oxoacid metabolic process#GO:0043436;heterocycle metabolic process#GO:0046483;acyl-CoA metabolic process#GO:0006637;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;ribonucleotide metabolic process#GO:0009259;monocarboxylic acid metabolic process#GO:0032787;fatty acid catabolic process#GO:0009062;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;fatty acid metabolic process#GO:0006631;small molecule catabolic process#GO:0044282;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;cellular lipid metabolic process#GO:0044255;carboxylic acid metabolic process#GO:0019752;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329 esterase#PC00097 HELRO|EnsemblGenome=HelroG156379|UniProtKB=T1ELU8 T1ELU8 20197548 PTHR13149:SF0 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25 VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25 identical protein binding#GO:0042802;protein binding#GO:0005515;binding#GO:0005488 endosomal transport#GO:0016197;cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;protein catabolic process#GO:0030163;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;nitrogen compound transport#GO:0071705;organonitrogen compound catabolic process#GO:1901565;late endosome to vacuole transport#GO:0045324;protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043328;establishment of protein localization#GO:0045184;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;modification-dependent macromolecule catabolic process#GO:0043632;organic substance transport#GO:0071702;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein localization to organelle#GO:0033365;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;establishment of protein localization to vacuole#GO:0072666;modification-dependent protein catabolic process#GO:0019941;vacuolar transport#GO:0007034;macromolecule metabolic process#GO:0043170;protein localization to vacuole#GO:0072665;organonitrogen compound metabolic process#GO:1901564;establishment of protein localization to organelle#GO:0072594;vesicle-mediated transport#GO:0016192;multivesicular body sorting pathway#GO:0071985;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein localization#GO:0008104;ubiquitin-dependent protein catabolic process#GO:0006511;localization#GO:0051179;cellular macromolecule localization#GO:0070727;protein transport#GO:0015031;endosome transport via multivesicular body sorting pathway#GO:0032509;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endosome membrane#GO:0010008;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cytoplasmic vesicle membrane#GO:0030659 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG76139|UniProtKB=T1G2F5 T1G2F5 20215253 PTHR47633:SF4 IMMUNOGLOBULIN MYOPALLADIN ISOFORM X1 HELRO|EnsemblGenome=HelroG178254|UniProtKB=T1FCZ9 T1FCZ9 20206698 PTHR10159:SF519 DUAL SPECIFICITY PROTEIN PHOSPHATASE DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;dephosphorylation#GO:0016311;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein phosphatase#PC00195;protein modifying enzyme#PC00260 Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG185294|UniProtKB=T1FMM4 T1FMM4 20210073 PTHR45715:SF3 ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED ATPASE H+ TRANSPORTING V1 SUBUNIT E1 inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;proton transmembrane transporter activity#GO:0015078;active monoatomic ion transmembrane transporter activity#GO:0022853;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;inorganic cation transmembrane transporter activity#GO:0022890 HELRO|EnsemblGenome=HelroG193055|UniProtKB=T1FUK8 T1FUK8 20212504 PTHR45662:SF8 PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1 PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC2 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 phospholipid dephosphorylation#GO:0046839;lipid metabolic process#GO:0006629;phosphatidylinositol dephosphorylation#GO:0046856;regulation of localization#GO:0032879;cellular metabolic process#GO:0044237;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;lipid modification#GO:0030258;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;regulation of cellular localization#GO:0060341;phosphorus metabolic process#GO:0006793;regulation of vesicle-mediated transport#GO:0060627;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;glycerolipid metabolic process#GO:0046486;regulation of transport#GO:0051049;regulation of cellular process#GO:0050794;dephosphorylation#GO:0016311;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;early endosome#GO:0005769;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;clathrin-coated vesicle#GO:0030136;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;endoplasmic reticulum#GO:0005783 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG183468|UniProtKB=T1FJQ3 T1FJQ3 20209052 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG84695|UniProtKB=T1G5M3 T1G5M3 20216370 PTHR10484:SF162 HISTONE H4 HISTONE H4-LIKE PROTEIN TYPE G nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;nucleosome organization#GO:0034728;nucleosome assembly#GO:0006334;protein-containing complex organization#GO:0043933;protein-containing complex assembly#GO:0065003;chromatin organization#GO:0006325;cellular component organization#GO:0016043;cellular process#GO:0009987;chromatin remodeling#GO:0006338;protein-DNA complex assembly#GO:0065004 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG142779|UniProtKB=T1EJ74 T1EJ74 20196624 PTHR11636:SF89 POU DOMAIN POU DOMAIN PROTEIN 2, ISOFORM B-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG177281|UniProtKB=T1FBG1 T1FBG1 20206160 PTHR31395:SF26 SHISA STANLEY-CUP scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG115552|UniProtKB=T1EG91 T1EG91 20195593 PTHR11525:SF0 FARNESYL-PYROPHOSPHATE SYNTHETASE FARNESYL PYROPHOSPHATE SYNTHASE prenyltransferase activity#GO:0004659;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;isoprenoid metabolic process#GO:0006720;phosphorus metabolic process#GO:0006793;isoprenoid biosynthetic process#GO:0008299;phosphate-containing compound metabolic process#GO:0006796;primary metabolic process#GO:0044238;terpenoid biosynthetic process#GO:0016114;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;terpenoid metabolic process#GO:0006721;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 acyltransferase#PC00042;metabolite interconversion enzyme#PC00262 Cholesterol biosynthesis#P00014>Geranyl trans-transferase#P00493 HELRO|EnsemblGenome=HelroG70359|UniProtKB=T1G054 T1G054 20214452 PTHR10913:SF78 FOLLISTATIN-RELATED AGRIN multicellular organismal process#GO:0032501;cellular developmental process#GO:0048869;cell differentiation#GO:0030154;cellular process#GO:0009987;anatomical structure development#GO:0048856;multicellular organism development#GO:0007275;developmental process#GO:0032502 cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG67906|UniProtKB=T1FZ75 T1FZ75 20214123 PTHR15614:SF2 INTRAFLAGELLAR TRANSPORT PROTEIN 81 HOMOLOG INTRAFLAGELLAR TRANSPORT PROTEIN 81 HOMOLOG cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 cilium organization#GO:0044782;cellular localization#GO:0051641;cell projection organization#GO:0030030;transport#GO:0006810;microtubule-based movement#GO:0007018;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;transport along microtubule#GO:0010970;intraciliary transport#GO:0042073;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;microtubule-based transport#GO:0099111;establishment of localization#GO:0051234;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;protein-containing complex localization#GO:0031503 microtubule organizing center#GO:0005815;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;intraciliary transport particle B#GO:0030992;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929;intraciliary transport particle#GO:0030990 HELRO|EnsemblGenome=HelroG82586|UniProtKB=T1G4U1 T1G4U1 20216089 PTHR24416:SF609 TYROSINE-PROTEIN KINASE RECEPTOR PROTEIN KINASE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG164888|UniProtKB=T1EVX2 T1EVX2 20200722 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG154240|UniProtKB=T1ELE2 T1ELE2 20197392 PTHR23137:SF6 VESICLE TRANSPORT PROTEIN-RELATED VESICLE TRANSPORT PROTEIN HELRO|EnsemblGenome=HelroG185213|UniProtKB=T1FMI6 T1FMI6 20210035 PTHR23091:SF4 N-TERMINAL ACETYLTRANSFERASE N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG124681|UniProtKB=T1EH25 T1EH25 20195875 PTHR22599:SF21 MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB MOB KINASE ACTIVATOR 2 protein kinase activator activity#GO:0030295;protein kinase regulator activity#GO:0019887;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234;kinase activator activity#GO:0019209 positive regulation of nitrogen compound metabolic process#GO:0051173;signal transduction#GO:0007165;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;positive regulation of protein modification process#GO:0031401;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of metabolic process#GO:0009893;positive regulation of biological process#GO:0048518;signaling#GO:0023052;positive regulation of protein phosphorylation#GO:0001934;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;positive regulation of protein metabolic process#GO:0051247;positive regulation of phosphate metabolic process#GO:0045937;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of protein phosphorylation#GO:0001932;biological regulation#GO:0065007;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 kinase modulator#PC00140;kinase activator#PC00138 HELRO|EnsemblGenome=HelroG90179|UniProtKB=T1G7L9 T1G7L9 20217066 PTHR10173:SF52 METHIONINE SULFOXIDE REDUCTASE METHIONINE-R-SULFOXIDE REDUCTASE B1 oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 reductase#PC00198;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG164567|UniProtKB=T1EVK6 T1EVK6 20200606 PTHR13408:SF0 DNA-DIRECTED RNA POLYMERASE III DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;transcription by RNA polymerase III#GO:0006383;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;ncRNA transcription#GO:0098781;aromatic compound biosynthetic process#GO:0019438;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;RNA polymerase III complex#GO:0005666;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG189101|UniProtKB=T1FQN3 T1FQN3 20211130 PTHR12271:SF40 POLY A POLYMERASE CID PAP -RELATED POLY(A) RNA POLYMERASE GLD2 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 nucleotidyltransferase#PC00174 HELRO|EnsemblGenome=HelroG74790|UniProtKB=T1G1V7 T1G1V7 20215055 PTHR45646:SF11 SERINE/THREONINE-PROTEIN KINASE DOA-RELATED SERINE_THREONINE-PROTEIN KINASE DOA transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG176768|UniProtKB=T1FAW2 T1FAW2 20205961 PTHR18945:SF925 NEUROTRANSMITTER GATED ION CHANNEL DUF4706 DOMAIN-CONTAINING PROTEIN ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG64031|UniProtKB=T1FXN5 T1FXN5 20213583 PTHR10176:SF3 GLYCOGEN SYNTHASE GLYCOGEN [STARCH] SYNTHASE UDP-glucosyltransferase activity#GO:0035251;transferase activity#GO:0016740;glucosyltransferase activity#GO:0046527;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758 glucan metabolic process#GO:0044042;carbohydrate biosynthetic process#GO:0016051;macromolecule biosynthetic process#GO:0009059;polysaccharide biosynthetic process#GO:0000271;macromolecule metabolic process#GO:0043170;glycogen metabolic process#GO:0005977;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;glycogen biosynthetic process#GO:0005978;energy derivation by oxidation of organic compounds#GO:0015980;primary metabolic process#GO:0044238;polysaccharide metabolic process#GO:0005976;glucan biosynthetic process#GO:0009250;energy reserve metabolic process#GO:0006112;carbohydrate metabolic process#GO:0005975;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185885|UniProtKB=T1FNE3 T1FNE3 20210340 PTHR11588:SF499 TUBULIN TUBULIN ALPHA-3 CHAIN carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;structural molecule activity#GO:0005198;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;structural constituent of cytoskeleton#GO:0005200 cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;microtubule-based process#GO:0007017;organelle organization#GO:0006996;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;cell cycle#GO:0007049;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 tubulin#PC00228;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG163325|UniProtKB=T1ETW9 T1ETW9 20200019 PTHR46989:SF3 USP DOMAIN-CONTAINING PROTEIN USPA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG80372|UniProtKB=T1G3Z9 T1G3Z9 20215797 PTHR24235:SF12 NEUROPEPTIDE Y RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG177626|UniProtKB=T1FBY4 T1FBY4 20206333 PTHR11533:SF299 PROTEASE M1 ZINC METALLOPROTEASE AMINOPEPTIDASE metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;amide binding#GO:0033218;metal ion binding#GO:0046872;peptidase activity#GO:0008233;metalloaminopeptidase activity#GO:0070006;cation binding#GO:0043169;peptide binding#GO:0042277;hydrolase activity#GO:0016787;aminopeptidase activity#GO:0004177;exopeptidase activity#GO:0008238;ion binding#GO:0043167;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;peptide catabolic process#GO:0043171;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;membrane#GO:0016020;extracellular region#GO:0005576;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG175168|UniProtKB=T1F8Y4 T1F8Y4 20205283 PTHR11533:SF174 PROTEASE M1 ZINC METALLOPROTEASE PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;amide binding#GO:0033218;metal ion binding#GO:0046872;peptidase activity#GO:0008233;metalloaminopeptidase activity#GO:0070006;cation binding#GO:0043169;peptide binding#GO:0042277;hydrolase activity#GO:0016787;aminopeptidase activity#GO:0004177;exopeptidase activity#GO:0008238;ion binding#GO:0043167;catalytic activity, acting on a protein#GO:0140096 nitrogen compound metabolic process#GO:0006807;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;catabolic process#GO:0009056;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;peptide catabolic process#GO:0043171;organic substance catabolic process#GO:1901575;cellular process#GO:0009987;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;membrane#GO:0016020;extracellular region#GO:0005576;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG177025|UniProtKB=T1FB56 T1FB56 20206055 PTHR45989:SF1 TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA nucleoside-triphosphatase regulator activity#GO:0060589;nucleic acid binding#GO:0003676;translation regulator activity#GO:0045182;GTPase regulator activity#GO:0030695;binding#GO:0005488;organic cyclic compound binding#GO:0097159;molecular function regulator activity#GO:0098772;translation initiation factor activity#GO:0003743;translation regulator activity, nucleic acid binding#GO:0090079;enzyme regulator activity#GO:0030234;translation factor activity, RNA binding#GO:0008135;guanyl-nucleotide exchange factor activity#GO:0005085 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cytoplasmic translation#GO:0002181;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cytoplasmic translational initiation#GO:0002183;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;translational initiation#GO:0006413;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;guanyl-nucleotide exchange factor complex#GO:0032045;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG88858|UniProtKB=T1G771 T1G771 20216918 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG73589|UniProtKB=T1G1G2 T1G1G2 20214910 PTHR48025:SF1 OS02G0815200 PROTEIN RRM DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183959|UniProtKB=T1FKC8 T1FKC8 20209277 PTHR10656:SF42 CELL FATE DETERMINING PROTEIN MAB21-RELATED CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED transferase#PC00220;nucleotidyltransferase#PC00174;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG194509|UniProtKB=T1FW49 T1FW49 20213045 PTHR21682:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 149 COILED-COIL DOMAIN-CONTAINING PROTEIN 149 HELRO|EnsemblGenome=HelroG149394|UniProtKB=T1EKC9 T1EKC9 20197029 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG117205|UniProtKB=T1EGL1 T1EGL1 20195711 PTHR24185:SF1 CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;phospholipase activity#GO:0004620;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;oxoacid metabolic process#GO:0043436;fatty acid metabolic process#GO:0006631;cellular metabolic process#GO:0044237;cellular process#GO:0009987;cellular lipid metabolic process#GO:0044255;organic acid metabolic process#GO:0006082;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;membrane#GO:0016020 phospholipase#PC00186;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG175003|UniProtKB=T1F8Q1 T1F8Q1 20205200 PTHR11746:SF199 O-METHYLTRANSFERASE ACETYLSEROTONIN O-METHYLTRANSFERASE methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG189099|UniProtKB=T1FQN1 T1FQN1 20211128 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG113026|UniProtKB=T1EFP7 T1EFP7 20195399 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG91609|UniProtKB=T1G861 T1G861 20217258 PTHR12675:SF12 MUSCLEBLIND-LIKE PROTEIN PROTEIN MUSCLEBLIND nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nitrogen compound metabolic process#GO:0051171;regulation of biosynthetic process#GO:0009889;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG168721|UniProtKB=T1F0W2 T1F0W2 20202462 PTHR31882:SF11 TNFAIP3-INTERACTING PROTEIN COILED COIL FAMILY MEMBER HDA1 COMPLEX SUBUNIT 2 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 HELRO|EnsemblGenome=HelroG174542|UniProtKB=T1F886 T1F886 20205035 PTHR48043:SF145 EG:EG0003.4 PROTEIN-RELATED FI06409P-RELATED HELRO|EnsemblGenome=HelroG76841|UniProtKB=T1G2Q0 T1G2Q0 20215348 PTHR34924:SF1 UPF0573 PROTEIN C2ORF70 PROTEIN FAM166C HELRO|EnsemblGenome=HelroG189514|UniProtKB=T1FR43 T1FR43 20211290 PTHR23078:SF3 VESICULAR-FUSION PROTEIN NSF VESICLE-FUSING ATPASE pyrophosphatase activity#GO:0016462;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ATP hydrolysis activity#GO:0016887;ribonucleoside triphosphate phosphatase activity#GO:0017111 protein localization to plasma membrane#GO:0072659;localization within membrane#GO:0051668;cellular localization#GO:0051641;vesicle-mediated transport to the plasma membrane#GO:0098876;intra-Golgi vesicle-mediated transport#GO:0006891;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;post-Golgi vesicle-mediated transport#GO:0006892;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;establishment of protein localization#GO:0045184;Golgi to plasma membrane transport#GO:0006893;protein localization#GO:0008104;localization#GO:0051179;protein localization to cell periphery#GO:1990778;establishment of protein localization to membrane#GO:0090150;organic substance transport#GO:0071702;Golgi to plasma membrane protein transport#GO:0043001;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein transport#GO:0015031 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi apparatus subcompartment#GO:0098791;cellular anatomical entity#GO:0110165;organelle#GO:0043226;Golgi stack#GO:0005795;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 Ionotropic glutamate receptor pathway#P00037>NSF#P01020;Synaptic vesicle trafficking#P05734>NSF#P05774 HELRO|EnsemblGenome=HelroG184582|UniProtKB=T1FLI9 T1FLI9 20209688 PTHR47160:SF5 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG114581|UniProtKB=T1EG33 T1EG33 20195535 PTHR24379:SF121 KRAB AND ZINC FINGER DOMAIN-CONTAINING C2H2-TYPE DOMAIN-CONTAINING PROTEIN C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG92479|UniProtKB=T1G8H1 T1G8H1 20217368 PTHR48112:SF22 HIGH MOBILITY GROUP PROTEIN DSP1 MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG178803|UniProtKB=T1FDR5 T1FDR5 20206964 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG190628|UniProtKB=T1FS56 T1FS56 20211653 PTHR10099:SF1 PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 De novo purine biosynthesis#P02738>Phosphoribosylformylglycinamide synthase#P02898 HELRO|EnsemblGenome=HelroG169296|UniProtKB=T1F1R0 T1F1R0 20202760 PTHR23419:SF8 DIVALENT CATION TOLERANCE CUTA-RELATED FI09726P copper ion binding#GO:0005507;cation binding#GO:0043169;metal ion binding#GO:0046872;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;transition metal ion binding#GO:0046914 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG111611|UniProtKB=T1EFC8 T1EFC8 20195280 PTHR23318:SF0 ATP SYNTHASE GAMMA-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3 phosphatase regulator activity#GO:0019208;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888 macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;dephosphorylation#GO:0016311;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;protein metabolic process#GO:0019538;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG160003|UniProtKB=T1EPN2 T1EPN2 20198532 PTHR46601:SF1 ULP_PROTEASE DOMAIN-CONTAINING PROTEIN ADF-H DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177329|UniProtKB=T1FBI2 T1FBI2 20206181 PTHR22801:SF63 LITHOSTATHINE C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG80417|UniProtKB=T1G402 T1G402 20215800 PTHR17602:SF4 RIBOSOME BIOGENESIS REGULATORY PROTEIN RIBOSOME BIOGENESIS REGULATORY PROTEIN HOMOLOG cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;ribosomal large subunit biogenesis#GO:0042273;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;ribosome biogenesis#GO:0042254;maturation of 5.8S rRNA#GO:0000460;endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000447;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;preribosome, large subunit precursor#GO:0030687;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG133608|UniProtKB=T1EI16 T1EI16 20196216 PTHR24241:SF76 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR NEUROPEPTIDE SIFAMIDE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;binding#GO:0005488;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888;amide binding#GO:0033218 response to organic substance#GO:0010033;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;response to hormone#GO:0009725;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG167008|UniProtKB=T1EYW2 T1EYW2 20201762 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185827|UniProtKB=T1FNC3 T1FNC3 20210320 PTHR19211:SF117 ATP-BINDING TRANSPORT PROTEIN-RELATED ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3 nucleotide binding#GO:0000166;carbohydrate derivative binding#GO:0097367;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168;ATP binding#GO:0005524 translation elongation factor#PC00222;translational protein#PC00263 HELRO|EnsemblGenome=HelroG190271|UniProtKB=T1FRU5 T1FRU5 20211542 PTHR24404:SF78 ZINC FINGER PROTEIN ZINC FINGER PROTEIN ZTF-16 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG84431|UniProtKB=T1G5I5 T1G5I5 20216332 PTHR10623:SF6 MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER EB1, ISOFORM F-RELATED cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;microtubule plus-end binding#GO:0051010;binding#GO:0005488 regulation of microtubule-based process#GO:0032886;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;macromolecule localization#GO:0033036;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;regulation of cellular component organization#GO:0051128;chromosome segregation#GO:0007059;regulation of biological process#GO:0050789;regulation of cytoskeleton organization#GO:0051493;regulation of microtubule cytoskeleton organization#GO:0070507;spindle assembly#GO:0051225;cytoskeleton organization#GO:0007010;spindle organization#GO:0007051;protein localization to organelle#GO:0033365;non-membrane-bounded organelle assembly#GO:0140694;cellular component assembly#GO:0022607;regulation of organelle organization#GO:0033043;cellular component organization#GO:0016043;regulation of microtubule polymerization or depolymerization#GO:0031110;cellular process#GO:0009987;protein localization#GO:0008104;organelle assembly#GO:0070925;localization#GO:0051179;protein localization to cytoskeleton#GO:0044380;cellular component organization or biogenesis#GO:0071840;cellular macromolecule localization#GO:0070727;microtubule-based process#GO:0007017;regulation of cellular process#GO:0050794;organelle organization#GO:0006996;biological regulation#GO:0065007;cell cycle#GO:0007049 supramolecular complex#GO:0099080;spindle midzone#GO:0051233;microtubule organizing center#GO:0005815;cytoplasmic microtubule#GO:0005881;supramolecular polymer#GO:0099081;cellular anatomical entity#GO:0110165;supramolecular fiber#GO:0099512;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cytoskeleton#GO:0005856;microtubule plus-end#GO:0035371;spindle#GO:0005819;microtubule#GO:0005874 non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG169845|UniProtKB=T1F2D4 T1F2D4 20202984 PTHR13800:SF1 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPM monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic cation transport#GO:0006812;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG158544|UniProtKB=T1EMX9 T1EMX9 20197929 PTHR19303:SF71 TRANSPOSON ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG184108|UniProtKB=T1FKL4 T1FKL4 20209363 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191161|UniProtKB=T1FSP0 T1FSP0 20211837 PTHR11630:SF44 DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER DNA REPLICATION LICENSING FACTOR MCM2 ATP-dependent activity, acting on DNA#GO:0008094;nucleic acid binding#GO:0003676;3'-5' DNA helicase activity#GO:0043138;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;single-stranded DNA binding#GO:0003697;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;catalytic activity, acting on a nucleic acid#GO:0140640;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097;single-stranded DNA helicase activity#GO:0017116 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;double-strand break repair#GO:0006302;cell cycle process#GO:0022402;nucleobase-containing compound metabolic process#GO:0006139;mitotic cell cycle process#GO:1903047;DNA geometric change#GO:0032392;DNA damage response#GO:0006974;mitotic cell cycle#GO:0000278;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;recombinational repair#GO:0000725;DNA duplex unwinding#GO:0032508;DNA-templated DNA replication#GO:0006261;cell cycle DNA replication#GO:0044786;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;nuclear DNA replication#GO:0033260;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;DNA unwinding involved in DNA replication#GO:0006268;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;double-strand break repair via homologous recombination#GO:0000724;cellular process#GO:0009987;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;DNA conformation change#GO:0071103;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;mitotic DNA replication initiation#GO:1902975;response to stress#GO:0006950;double-strand break repair via break-induced replication#GO:0000727;organelle organization#GO:0006996;chromosome organization#GO:0051276;mitotic DNA replication#GO:1902969;cell cycle#GO:0007049;cellular response to stress#GO:0033554;DNA replication#GO:0006260;DNA replication initiation#GO:0006270;DNA metabolic process#GO:0006259 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;MCM complex#GO:0042555;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG186206|UniProtKB=T1FNT4 T1FNT4 20210481 PTHR43272:SF32 LONG-CHAIN-FATTY-ACID--COA LIGASE AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN long-chain fatty acid-CoA ligase activity#GO:0004467;ligase activity#GO:0016874;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG185706|UniProtKB=T1FN62 T1FN62 20210260 PTHR44090:SF1 WD REPEAT-CONTAINING PROTEIN 61 SUPERKILLER COMPLEX PROTEIN 8 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;transcription elongation factor complex#GO:0008023;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase II, holoenzyme#GO:0016591;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;Cdc73/Paf1 complex#GO:0016593;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG111078|UniProtKB=T1EF77 T1EF77 20195229 PTHR43530:SF1 QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1 QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1 catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;pentosyltransferase activity#GO:0016763;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG112993|UniProtKB=T1EFP3 T1EFP3 20195395 PTHR23316:SF71 IMPORTIN ALPHA IMPORTIN SUBUNIT ALPHA signal sequence binding#GO:0005048;binding#GO:0005488;amide binding#GO:0033218;peptide binding#GO:0042277 cellular localization#GO:0051641;NLS-bearing protein import into nucleus#GO:0006607;macromolecule localization#GO:0033036;transport#GO:0006810;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;protein import into nucleus#GO:0006606;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365;nuclear transport#GO:0051169;import into nucleus#GO:0051170 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG81674|UniProtKB=T1G4H3 T1G4H3 20215971 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG75473|UniProtKB=T1G255 T1G255 20215153 PTHR10972:SF215 OXYSTEROL-BINDING PROTEIN-RELATED PH DOMAIN-CONTAINING PROTEIN binding#GO:0005488;organic cyclic compound binding#GO:0097159;sterol transporter activity#GO:0015248;steroid binding#GO:0005496;sterol binding#GO:0032934;lipid binding#GO:0008289;lipid transporter activity#GO:0005319;transporter activity#GO:0005215 cytoplasm#GO:0005737;perinuclear region of cytoplasm#GO:0048471;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG64552|UniProtKB=T1FXW4 T1FXW4 20213662 PTHR24248:SF125 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR DOPAMINE D2-LIKE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG167362|UniProtKB=T1EZB0 T1EZB0 20201910 PTHR16095:SF11 TRANSMEMBRANE PROTEIN 143 FAMILY MEMBER TRANSMEMBRANE PROTEIN 143 HELRO|EnsemblGenome=HelroG180916|UniProtKB=T1FGE8 T1FGE8 20207897 PTHR35683:SF4 YALI0C04136P AGAP002273-PA HELRO|EnsemblGenome=HelroG76996|UniProtKB=T1G2S2 T1G2S2 20215370 PTHR45982:SF1 REGULATOR OF CHROMOSOME CONDENSATION REGULATOR OF CHROMOSOME CONDENSATION HELRO|EnsemblGenome=HelroG193720|UniProtKB=T1FVA5 T1FVA5 20212751 PTHR19232:SF7 CENTROCORTIN FAMILY MEMBER CENTROCORTIN, ISOFORM A HELRO|EnsemblGenome=HelroG69219|UniProtKB=T1FZR2 T1FZR2 20214310 PTHR11575:SF48 5'-NUCLEOTIDASE-RELATED 5'-NUCLEOTIDASE phosphodiesterase#PC00185;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG181023|UniProtKB=T1FGJ5 T1FGJ5 20207944 PTHR10334:SF590 CYSTEINE-RICH SECRETORY PROTEIN-RELATED SCP DOMAIN-CONTAINING PROTEIN extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG173100|UniProtKB=T1F6C4 T1F6C4 20204373 PTHR33332:SF48 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185816|UniProtKB=T1FNB9 T1FNB9 20210316 PTHR45688:SF3 FAMILY NOT NAMED ALANINE--GLYOXYLATE AMINOTRANSFERASE 2, MITOCHONDRIAL HELRO|EnsemblGenome=HelroG80006|UniProtKB=T1G3W4 T1G3W4 20215762 PTHR23167:SF86 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG173560|UniProtKB=T1F6Z2 T1F6Z2 20204591 PTHR23107:SF34 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN HTH LA-TYPE RNA-BINDING DOMAIN-CONTAINING PROTEIN transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG161967|UniProtKB=T1ES36 T1ES36 20199386 PTHR12766:SF7 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DEATH DOMAIN-ASSOCIATED PROTEIN 6 FAS signaling pathway#P00020>DAXX#P00602;Apoptosis signaling pathway#P00006>DAXX#P00296 HELRO|EnsemblGenome=HelroG192208|UniProtKB=T1FTP5 T1FTP5 20212192 PTHR21559:SF21 DYSTROGLYCAN-RELATED DYSTROGLYCAN 1 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG172857|UniProtKB=T1F609 T1F609 20204258 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG102800|UniProtKB=T1EDC0 T1EDC0 20194572 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;chloride transmembrane transporter activity#GO:0015108;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;inorganic anion transmembrane transport#GO:0098661;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic anion transport#GO:0006820;chloride transport#GO:0006821;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;inorganic anion transport#GO:0015698 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG91513|UniProtKB=T1G848 T1G848 20217245 PTHR11096:SF0 RNA 3' TERMINAL PHOSPHATE CYCLASE RNA 3'-TERMINAL PHOSPHATE CYCLASE catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;ligase activity#GO:0016874;cyclase activity#GO:0009975;catalytic activity#GO:0003824 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG167782|UniProtKB=T1EZS8 T1EZS8 20202078 PTHR10910:SF62 EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN AT07585P-RELATED nucleic acid binding#GO:0003676;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;adenosine deaminase activity#GO:0004000;RNA binding#GO:0003723;tRNA-specific adenosine deaminase activity#GO:0008251;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;deaminase activity#GO:0019239;double-stranded RNA binding#GO:0003725 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;adenosine to inosine editing#GO:0006382;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG161732|UniProtKB=T1ERU6 T1ERU6 20199296 PTHR47537:SF6 CUBILIN CUB DOMAIN-CONTAINING PROTEIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG180058|UniProtKB=T1FFF0 T1FFF0 20207549 PTHR11360:SF260 MONOCARBOXYLATE TRANSPORTER MFS DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;monocarboxylic acid transmembrane transporter activity#GO:0008028;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;monocarboxylic acid transport#GO:0015718;establishment of localization#GO:0051234;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942 transporter#PC00227 HELRO|EnsemblGenome=HelroG81988|UniProtKB=T1G4L3 T1G4L3 20216011 PTHR10730:SF45 PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG133824|UniProtKB=T1EI26 T1EI26 20196226 PTHR12215:SF10 PHOSPHOPANTETHEINE TRANSFERASE L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;proteinogenic amino acid biosynthetic process#GO:0170038;lysine biosynthetic process#GO:0009085;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;aspartate family amino acid biosynthetic process#GO:0009067;alpha-amino acid biosynthetic process#GO:1901607;nitrogen compound metabolic process#GO:0006807;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;aspartate family amino acid metabolic process#GO:0009066;small molecule biosynthetic process#GO:0044283;L-amino acid biosynthetic process#GO:0170034;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG78642|UniProtKB=T1G3E0 T1G3E0 20215588 PTHR10024:SF227 SYNAPTOTAGMIN SYNAPTOTAGMIN 1 cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;phosphatidylserine binding#GO:0001786;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;protein binding#GO:0005515;clathrin binding#GO:0030276;lipid binding#GO:0008289;ion binding#GO:0043167;phospholipid binding#GO:0005543;SNARE binding#GO:0000149 cellular localization#GO:0051641;synaptic vesicle cycle#GO:0099504;synaptic vesicle endocytosis#GO:0048488;transport#GO:0006810;regulation of biological process#GO:0050789;regulated exocytosis#GO:0045055;synaptic vesicle recycling#GO:0036465;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;secretion#GO:0046903;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;signal release#GO:0023061;calcium-ion regulated exocytosis#GO:0017156;cell-cell signaling#GO:0007267;signaling#GO:0023052;synaptic vesicle exocytosis#GO:0016079;secretion by cell#GO:0032940;neurotransmitter secretion#GO:0007269;endocytosis#GO:0006897;trans-synaptic signaling#GO:0099537;vesicle-mediated transport#GO:0016192;cell communication#GO:0007154;cellular process#GO:0009987;localization#GO:0051179;signal release from synapse#GO:0099643;exocytosis#GO:0006887;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;import into cell#GO:0098657;export from cell#GO:0140352;vesicle-mediated transport in synapse#GO:0099003 intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;secretory vesicle#GO:0099503;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG169136|UniProtKB=T1F1G1 T1F1G1 20202661 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG105001|UniProtKB=T1EDP7 T1EDP7 20194699 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;heme binding#GO:0020037 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG157178|UniProtKB=T1EM76 T1EM76 20197676 PTHR13200:SF0 EEF1A LYSINE METHYLTRANSFERASE 1 EEF1A LYSINE METHYLTRANSFERASE 1 HELRO|EnsemblGenome=HelroG91542|UniProtKB=T1G852 T1G852 20217249 PTHR47219:SF9 RAB GTPASE-ACTIVATING PROTEIN 1-LIKE GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B nucleoside-triphosphatase regulator activity#GO:0060589;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;binding#GO:0005488;molecular function regulator activity#GO:0098772;enzyme binding#GO:0019899;protein binding#GO:0005515;enzyme activator activity#GO:0008047;small GTPase binding#GO:0031267;enzyme regulator activity#GO:0030234 biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG65566|UniProtKB=T1FY99 T1FY99 20213797 PTHR22891:SF111 EUKARYOTIC TRANSLATION INITIATION FACTOR 2C PROTEIN ARGONAUTE-3 catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;nuclease activity#GO:0004518;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521 negative regulation of gene expression#GO:0010629;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;P granule#GO:0043186;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG183744|UniProtKB=T1FK47 T1FK47 20209196 PTHR24241:SF193 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;binding#GO:0005488;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888;amide binding#GO:0033218 response to organic substance#GO:0010033;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;response to hormone#GO:0009725;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG70089|UniProtKB=T1G026 T1G026 20214424 PTHR12981:SF0 ZINC FINGER PROTEIN-LIKE 1 ZINC FINGER PROTEIN-LIKE 1 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG162203|UniProtKB=T1ESC8 T1ESC8 20199478 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED FMRFAMIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG109895|UniProtKB=T1EEX2 T1EEX2 20195124 PTHR12213:SF0 CORRINOID ADENOSYLTRANSFERASE CORRINOID ADENOSYLTRANSFERASE MMAB transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG68612|UniProtKB=T1FZH3 T1FZH3 20214221 PTHR11138:SF5 METHIONYL-TRNA FORMYLTRANSFERASE METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG190319|UniProtKB=T1FRW6 T1FRW6 20211563 PTHR31915:SF6 SKICH DOMAIN-CONTAINING PROTEIN SKICH DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168555|UniProtKB=T1F0Q2 T1F0Q2 20202402 PTHR19303:SF71 TRANSPOSON ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG81378|UniProtKB=T1G4D8 T1G4D8 20215936 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG166177|UniProtKB=T1EXV5 T1EXV5 20201405 PTHR34740:SF5 FINGER, C3HC4 TYPE, PUTATIVE-RELATED-RELATED POLYMERASE NUCLEOTIDYL TRANSFERASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188714|UniProtKB=T1FQA5 T1FQA5 20211002 PTHR13228:SF3 CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;Golgi vesicle transport#GO:0048193;intra-Golgi vesicle-mediated transport#GO:0006891;transport#GO:0006810 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;vesicle tethering complex#GO:0099023;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;Golgi transport complex#GO:0017119;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG81634|UniProtKB=T1G4G8 T1G4G8 20215966 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG193690|UniProtKB=T1FV94 T1FV94 20212740 PTHR22776:SF49 MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN MARVEL DOMAIN-CONTAINING PROTEIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG99285|UniProtKB=T1G9R9 T1G9R9 20217815 PTHR10010:SF46 SOLUTE CARRIER FAMILY 34 SODIUM PHOSPHATE , MEMBER 2-RELATED SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 2B secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG193237|UniProtKB=T1FUS1 T1FUS1 20212567 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170597|UniProtKB=T1F381 T1F381 20203280 PTHR23113:SF363 GUANINE NUCLEOTIDE EXCHANGE FACTOR PROTEIN SON OF SEVENLESS nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;Ras protein signal transduction#GO:0007265;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 FGF signaling pathway#P00021>SOS#P00641;Angiogenesis#P00005>SOS-1#P00193;Integrin signalling pathway#P00034>SOS#P00920;PDGF signaling pathway#P00047>SOS#P01159;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>SOS#P00883;EGF receptor signaling pathway#P00018>SOS#P00558;Ras Pathway#P04393>SOS#P04552 HELRO|EnsemblGenome=HelroG88426|UniProtKB=T1G723 T1G723 20216870 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-LIKE 1 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;localization#GO:0051179;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 membrane protein complex#GO:0098796;synapse#GO:0045202;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron projection#GO:0043005;transmembrane transporter complex#GO:1902495;cell projection#GO:0042995;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HELRO|EnsemblGenome=HelroG169848|UniProtKB=T1F2D5 T1F2D5 20202985 PTHR18947:SF39 HOOK PROTEINS PROTEIN HOOK cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 cellular localization#GO:0051641;transport#GO:0006810;microtubule cytoskeleton organization#GO:0000226;cellular component organization#GO:0016043;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;microtubule-based process#GO:0007017;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;cytoskeleton-dependent intracellular transport#GO:0030705;cytoskeleton organization#GO:0007010;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cytoplasmic microtubule organization#GO:0031122 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;centrosome#GO:0005813;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG105902|UniProtKB=T1EDY4 T1EDY4 20194786 PTHR13087:SF0 NF-KAPPA B ACTIVATING PROTEIN NFKB ACTIVATING PROTEIN LIKE regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG70757|UniProtKB=T1G0B8 T1G0B8 20214516 PTHR10736:SF65 BESTROPHIN BESTROPHIN 1, ISOFORM C-RELATED inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;channel activity#GO:0015267 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG77797|UniProtKB=T1G342 T1G342 20215490 PTHR22923:SF116 CEREBELLIN-RELATED C1Q DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG177449|UniProtKB=T1FBQ4 T1FBQ4 20206253 PTHR47055:SF3 DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 HELRO|EnsemblGenome=HelroG167033|UniProtKB=T1EYX5 T1EYX5 20201775 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG92182|UniProtKB=T1G8C7 T1G8C7 20217324 PTHR10390:SF61 HOMEOBOX PROTEIN SIX HOMEOBOX PROTEIN SIX2 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG194205|UniProtKB=T1FVS9 T1FVS9 20212925 PTHR15758:SF2 BCL-2-LIKE PROTEIN 13 BCL-2-LIKE PROTEIN 13 HELRO|EnsemblGenome=HelroG186197|UniProtKB=T1FNT0 T1FNT0 20210477 PTHR10263:SF18 V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT V-TYPE PROTON ATPASE 21 KDA PROTEOLIPID SUBUNIT C'' cellular anatomical entity#GO:0110165;membrane#GO:0016020 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG179196|UniProtKB=T1FEC3 T1FEC3 20207172 PTHR24339:SF67 HOMEOBOX PROTEIN EMX-RELATED GNOT1 HOMEODOMAIN PROTEIN-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;neurogenesis#GO:0022008;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;system development#GO:0048731;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;central nervous system development#GO:0007417;regulation of macromolecule biosynthetic process#GO:0010556;generation of neurons#GO:0048699;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG177885|UniProtKB=T1FCF1 T1FCF1 20206500 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG194828|UniProtKB=T1FWG5 T1FWG5 20213160 PTHR47958:SF32 ATP-DEPENDENT RNA HELICASE DBP3 RNA HELICASE nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG97407|UniProtKB=T1G9G6 T1G9G6 20217713 PTHR11347:SF209 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE PHOSPHODIESTERASE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric diester hydrolase activity#GO:0008081;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;heterocycle catabolic process#GO:0046700;cyclic nucleotide metabolic process#GO:0009187;organonitrogen compound catabolic process#GO:1901565;ribonucleotide catabolic process#GO:0009261;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;cellular nitrogen compound catabolic process#GO:0044270;phosphate-containing compound metabolic process#GO:0006796;purine-containing compound catabolic process#GO:0072523;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;purine nucleotide catabolic process#GO:0006195;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;purine ribonucleotide catabolic process#GO:0009154;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;nucleoside phosphate catabolic process#GO:1901292;carbohydrate derivative catabolic process#GO:1901136;organonitrogen compound metabolic process#GO:1901564;nucleotide catabolic process#GO:0009166;cellular metabolic process#GO:0044237;cell communication#GO:0007154;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;organophosphate catabolic process#GO:0046434;response to stimulus#GO:0050896;aromatic compound catabolic process#GO:0019439;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;nucleotide metabolic process#GO:0009117;cAMP-mediated signaling#GO:0019933;small molecule metabolic process#GO:0044281;nucleobase-containing small molecule metabolic process#GO:0055086;cyclic-nucleotide-mediated signaling#GO:0019935 phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG155753|UniProtKB=T1ELL9 T1ELL9 20197469 PTHR12882:SF1 SUPPRESSOR OF TY 4 TRANSCRIPTION ELONGATION FACTOR SPT4 basal RNA polymerase II transcription machinery binding#GO:0001099;RNA polymerase binding#GO:0070063;binding#GO:0005488;RNA polymerase core enzyme binding#GO:0043175;RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515;enzyme binding#GO:0019899;basal transcription machinery binding#GO:0001098 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;DNA-templated transcription elongation#GO:0006354;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nucleobase-containing compound biosynthetic process#GO:0034654;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;transcription elongation by RNA polymerase II#GO:0006368;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;transcription elongation factor complex#GO:0008023;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG163831|UniProtKB=T1EUI7 T1EUI7 20200237 PTHR47537:SF2 CUBILIN CUBILIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG190557|UniProtKB=T1FS31 T1FS31 20211628 PTHR12558:SF13 CELL DIVISION CYCLE 16,23,27 CELL DIVISION CYCLE PROTEIN 27 HOMOLOG ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG115589|UniProtKB=T1EG95 T1EG95 20195597 PTHR15075:SF2 ALPHA-MANNOSIDE BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE ALPHA-1,6-MANNOSYLGLYCOPROTEIN 6-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE acetylglucosaminyltransferase activity#GO:0008375;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG184881|UniProtKB=T1FM46 T1FM46 20209895 PTHR12780:SF1 RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC6 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;nuclear DNA-directed RNA polymerase complex#GO:0055029;RNA polymerase III complex#GO:0005666;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG71055|UniProtKB=T1G0G1 T1G0G1 20214559 PTHR10856:SF44 CORONIN CORONIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG191945|UniProtKB=T1FTF8 T1FTF8 20212105 PTHR11091:SF0 OXIDOREDUCTASE-RELATED MALATE DEHYDROGENASE oxidoreductase#PC00176 Pyruvate metabolism#P02772>Malate Dehydrogenase#P03138;TCA cycle#P00051>Malate Dehydrogenase#P01270;Allantoin degradation#P02725>Ureidoglycolate dehydrogenase#P02820 HELRO|EnsemblGenome=HelroG67985|UniProtKB=T1FZ90 T1FZ90 20214138 PTHR11596:SF5 ALKALINE PHOSPHATASE ALKALINE PHOSPHATASE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 cellular metabolic process#GO:0044237;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;dephosphorylation#GO:0016311;metabolic process#GO:0008152 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG181666|UniProtKB=T1FH79 T1FH79 20208178 PTHR46601:SF1 ULP_PROTEASE DOMAIN-CONTAINING PROTEIN ADF-H DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG64769|UniProtKB=T1FXY8 T1FXY8 20213686 PTHR24356:SF240 SERINE/THREONINE-PROTEIN KINASE PROTEIN KINASE C transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Alzheimer disease-amyloid secretase pathway#P00003>PKC#P00109;Endothelin signaling pathway#P00019>PKC#P00568;Angiogenesis#P00005>PKC#P00219;5HT2 type receptor mediated signaling pathway#P04374>PKC#P04420;EGF receptor signaling pathway#P00018>PKC#P00565;Histamine H1 receptor mediated signaling pathway#P04385>PKC#P04487;FGF signaling pathway#P00021>PKC#P00648;VEGF signaling pathway#P00056>PKC#P01425;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>PKC#P01074;Wnt signaling pathway#P00057>Protein Kinase C#P01458;Apoptosis signaling pathway#P00006>PKCs#P00318;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PKC#P04583;Oxytocin receptor mediated signaling pathway#P04391>PKC#P04533 HELRO|EnsemblGenome=HelroG162538|UniProtKB=T1EST4 T1EST4 20199634 PTHR46186:SF2 CYSTATIN CYSTATIN peptidase inhibitor activity#GO:0030414;molecular function regulator activity#GO:0098772;cysteine-type endopeptidase inhibitor activity#GO:0004869;peptidase regulator activity#GO:0061134;enzyme inhibitor activity#GO:0004857;endopeptidase regulator activity#GO:0061135;endopeptidase inhibitor activity#GO:0004866;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 regulation of proteolysis#GO:0030162;negative regulation of hydrolase activity#GO:0051346;negative regulation of biological process#GO:0048519;regulation of protein metabolic process#GO:0051246;regulation of cysteine-type endopeptidase activity#GO:2000116;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of cysteine-type endopeptidase activity#GO:2000117;negative regulation of peptidase activity#GO:0010466;negative regulation of endopeptidase activity#GO:0010951;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of proteolysis#GO:0045861;regulation of catalytic activity#GO:0050790;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of molecular function#GO:0065009;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336;regulation of endopeptidase activity#GO:0052548;regulation of peptidase activity#GO:0052547;negative regulation of catalytic activity#GO:0043086;regulation of metabolic process#GO:0019222;negative regulation of molecular function#GO:0044092 cytoplasm#GO:0005737;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG166133|UniProtKB=T1EXU1 T1EXU1 20201391 PTHR14618:SF0 HOMEODOX-CONTAINING PROTEIN 1 HMBOX1 HOMEOBOX-CONTAINING PROTEIN 1 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG191188|UniProtKB=T1FSQ4 T1FSQ4 20211851 PTHR23198:SF6 NUCLEOPORIN NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96 transporter#PC00227 HELRO|EnsemblGenome=HelroG67931|UniProtKB=T1FZ80 T1FZ80 20214128 PTHR31184:SF2 HUNTINGTIN-INTERACTING PROTEIN K FAMILY MEMBER HUNTINGTIN-INTERACTING PROTEIN K regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of apoptotic process#GO:0042981;regulation of biological quality#GO:0065008;negative regulation of programmed cell death#GO:0043069;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of protein stability#GO:0031647;negative regulation of cellular process#GO:0048523;negative regulation of apoptotic process#GO:0043066;protein stabilization#GO:0050821;regulation of programmed cell death#GO:0043067 HELRO|EnsemblGenome=HelroG82800|UniProtKB=T1G4W8 T1G4W8 20216116 PTHR12289:SF38 METAXIN RELATED METAXIN-2 cellular component organization or biogenesis#GO:0071840;mitochondrion organization#GO:0007005;cellular component organization#GO:0016043;cellular process#GO:0009987;organelle organization#GO:0006996 envelope#GO:0031975;bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane#GO:0005741;mitochondrial outer membrane translocase complex#GO:0005742;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867;mitochondrial protein-containing complex#GO:0098798 transporter#PC00227 HELRO|EnsemblGenome=HelroG84000|UniProtKB=T1G5D0 T1G5D0 20216277 PTHR24353:SF37 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;GABA-B receptor II signaling#P05731>PKA#P05752;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Enkephalin release#P05913>PKA#P05972;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Endothelin signaling pathway#P00019>PKG#P00567;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Endothelin signaling pathway#P00019>PKA#P00570;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059 HELRO|EnsemblGenome=HelroG194674|UniProtKB=T1FWA9 T1FWA9 20213105 PTHR47385:SF14 CALPONIN TRANSGELIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG110237|UniProtKB=T1EF08 T1EF08 20195160 PTHR10245:SF15 ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1 ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 HELRO|EnsemblGenome=HelroG181925|UniProtKB=T1FHG7 T1FHG7 20208266 PTHR18945:SF879 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission#GO:0007268;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 cell junction#GO:0030054;synapse#GO:0045202;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;neuron projection#GO:0043005 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG186296|UniProtKB=T1FNY0 T1FNY0 20210527 PTHR12862:SF0 BADF TYPE ATPASE DOMAIN-CONTAINING PROTEIN N-ACETYL-D-GLUCOSAMINE KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;carbohydrate kinase activity#GO:0019200;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301 HELRO|EnsemblGenome=HelroG93683|UniProtKB=T1G8X4 T1G8X4 20217521 PTHR28524:SF3 SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL chaperone#PC00072 HELRO|EnsemblGenome=HelroG184880|UniProtKB=T1FM45 T1FM45 20209894 PTHR31952:SF1 CB1 CANNABINOID RECEPTOR-INTERACTING PROTEIN 1 CB1 CANNABINOID RECEPTOR-INTERACTING PROTEIN 1 protein binding#GO:0005515;G protein-coupled receptor binding#GO:0001664;binding#GO:0005488;signaling receptor binding#GO:0005102 regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of molecular function#GO:0065009;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;regulation of signaling#GO:0023051;biological regulation#GO:0065007;negative regulation of molecular function#GO:0044092 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG156123|UniProtKB=T1ELR8 T1ELR8 20197518 PTHR44177:SF1 TETRATRICOPEPTIDE REPEAT PROTEIN 8 TETRATRICOPEPTIDE REPEAT PROTEIN 8 organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;non-motile cilium assembly#GO:1905515;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 microtubule organizing center#GO:0005815;non-motile cilium#GO:0097730;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cytoskeleton#GO:0005856;BBSome#GO:0034464;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG187947|UniProtKB=T1FPH9 T1FPH9 20210726 PTHR23176:SF133 RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN GTPASE-ACTIVATING PROTEIN PAC-1 biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG88997|UniProtKB=T1G780 T1G780 20216927 PTHR12968:SF1 B9 DOMAIN-CONTAINING B9 DOMAIN-CONTAINING PROTEIN 1 organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cilium#GO:0005929;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;ciliary transition zone#GO:0035869 structural protein#PC00211 HELRO|EnsemblGenome=HelroG172266|UniProtKB=T1F561 T1F561 20203960 PTHR15439:SF22 RETINOBLASTOMA-BINDING PROTEIN 6 C3H1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG175106|UniProtKB=T1F8V1 T1F8V1 20205250 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG194810|UniProtKB=T1FWF7 T1FWF7 20213152 PTHR13723:SF313 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;cellular component organization#GO:0016043;cellular process#GO:0009987;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG191118|UniProtKB=T1FSL9 T1FSL9 20211816 PTHR14948:SF25 NG5 DUF4190 DOMAIN-CONTAINING PROTEIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG68960|UniProtKB=T1FZM6 T1FZM6 20214274 PTHR11538:SF41 PHENYLALANYL-TRNA SYNTHETASE PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 aminoacyl-tRNA synthetase#PC00047 HELRO|EnsemblGenome=HelroG135380|UniProtKB=T1EI84 T1EI84 20196284 PTHR13610:SF9 METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN FI06469P N-methyltransferase activity#GO:0008170;transferase activity#GO:0016740;catalytic activity#GO:0003824;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;protein-lysine N-methyltransferase activity#GO:0016279;catalytic activity, acting on a protein#GO:0140096;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein methyltransferase activity#GO:0008276;lysine N-methyltransferase activity#GO:0016278 regulation of phosphate metabolic process#GO:0019220;macromolecule modification#GO:0043412;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of molecular function#GO:0044093;protein modification process#GO:0036211;positive regulation of cation channel activity#GO:2001259;regulation of localization#GO:0032879;peptidyl-amino acid modification#GO:0018193;regulation of monoatomic cation transmembrane transport#GO:1904062;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;regulation of transport#GO:0051049;regulation of molecular function#GO:0065009;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;regulation of monoatomic ion transmembrane transporter activity#GO:0032412;regulation of transmembrane transporter activity#GO:0022898;regulation of monoatomic ion transport#GO:0043269;protein metabolic process#GO:0019538;regulation of transporter activity#GO:0032409;positive regulation of biological process#GO:0048518;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;macromolecule metabolic process#GO:0043170;positive regulation of catalytic activity#GO:0043085;organonitrogen compound metabolic process#GO:1901564;positive regulation of transport#GO:0051050;positive regulation of cellular process#GO:0048522;primary metabolic process#GO:0044238;regulation of primary metabolic process#GO:0080090;macromolecule methylation#GO:0043414;regulation of cellular biosynthetic process#GO:0031326;methylation#GO:0032259;positive regulation of transporter activity#GO:0032411;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG181106|UniProtKB=T1FGM1 T1FGM1 20207970 PTHR10465:SF3 TRANSMEMBRANE GTPASE FZO1 TRANSMEMBRANE GTPASE MARF-RELATED GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 localization#GO:0051179;mitochondrial fusion#GO:0008053;cellular component organization or biogenesis#GO:0071840;organelle localization#GO:0051640;organelle organization#GO:0006996;cellular component organization#GO:0016043;mitochondrion organization#GO:0007005;cellular process#GO:0009987;organelle fusion#GO:0048284 envelope#GO:0031975;bounding membrane of organelle#GO:0098588;mitochondrial membrane#GO:0031966;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867 HELRO|EnsemblGenome=HelroG88257|UniProtKB=T1G707 T1G707 20216854 PTHR48041:SF116 ABC TRANSPORTER G FAMILY MEMBER 28 PROTEIN BROWN transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG159053|UniProtKB=T1ENJ3 T1ENJ3 20198143 PTHR14677:SF37 ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED AN1-TYPE ZINC FINGER PROTEIN 1 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG79615|UniProtKB=T1G3R0 T1G3R0 20215708 PTHR24343:SF348 SERINE/THREONINE KINASE AT25266P transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG66976|UniProtKB=T1FYU5 T1FYU5 20213993 PTHR45832:SF22 SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED HELRO|EnsemblGenome=HelroG164963|UniProtKB=T1EW08 T1EW08 20200758 PTHR25462:SF305 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG62909|UniProtKB=T1FX73 T1FX73 20213421 PTHR11920:SF462 GUANYLYL CYCLASE GUANYLATE CYCLASE adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG156435|UniProtKB=T1ELW6 T1ELW6 20197566 PTHR10137:SF0 V-TYPE PROTON ATPASE SUBUNIT C V-TYPE PROTON ATPASE SUBUNIT C inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;proton transmembrane transporter activity#GO:0015078;active monoatomic ion transmembrane transporter activity#GO:0022853;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;inorganic cation transmembrane transporter activity#GO:0022890;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;vacuolar membrane#GO:0005774;ATPase complex#GO:1904949;vacuole#GO:0005773;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;proton-transporting two-sector ATPase complex#GO:0016469;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG85470|UniProtKB=T1G5X5 T1G5X5 20216472 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG102301|UniProtKB=T1ED93 T1ED93 20194545 PTHR12086:SF9 EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN EF-HAND DOMAIN-CONTAINING PROTEIN 1 cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;tubulin binding#GO:0015631;alpha-tubulin binding#GO:0043014;binding#GO:0005488 cell division#GO:0051301;mitotic spindle organization#GO:0007052;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;cilium or flagellum-dependent cell motility#GO:0001539;cell motility#GO:0048870;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;cilium-dependent cell motility#GO:0060285;mitotic cytokinesis#GO:0000281;mitotic cell cycle#GO:0000278;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cytoskeleton-dependent cytokinesis#GO:0061640;cell cycle#GO:0007049;cytoskeleton organization#GO:0007010;spindle organization#GO:0007051;cytokinesis#GO:0000910 axoneme#GO:0005930;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;mitotic spindle#GO:0072686;microtubule cytoskeleton#GO:0015630;ciliary plasm#GO:0097014;plasma membrane bounded cell projection cytoplasm#GO:0032838;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929;spindle#GO:0005819 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG191702|UniProtKB=T1FT80 T1FT80 20212027 PTHR24027:SF441 CADHERIN-23 CADHERIN DOMAIN-CONTAINING PROTEIN cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;binding#GO:0005488;beta-catenin binding#GO:0008013 anatomical structure development#GO:0048856;multicellular organism development#GO:0007275;developmental process#GO:0032502;cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;multicellular organismal process#GO:0032501;cell motility#GO:0048870;cell adhesion#GO:0007155;cellular process#GO:0009987;cell migration#GO:0016477 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;extrinsic component of membrane#GO:0019898;plasma membrane#GO:0005886 cadherin#PC00057 HELRO|EnsemblGenome=HelroG182122|UniProtKB=T1FHS6 T1FHS6 20208375 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG178169|UniProtKB=T1FCV6 T1FCV6 20206655 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG107720|UniProtKB=T1EEC5 T1EEC5 20194927 PTHR10605:SF56 HEPARAN SULFATE SULFOTRANSFERASE BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG86631|UniProtKB=T1G6E6 T1G6E6 20216643 PTHR18945:SF865 NEUROTRANSMITTER GATED ION CHANNEL NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA7, ISOFORM E ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG185513|UniProtKB=T1FMX1 T1FMX1 20210170 PTHR44170:SF6 PROTEIN SIDEKICK CONTACTIN cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG182010|UniProtKB=T1FHL2 T1FHL2 20208311 PTHR23110:SF109 BTB DOMAIN TRANSCRIPTION FACTOR FI07618P-RELATED DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG175300|UniProtKB=T1F944 T1F944 20205343 PTHR21437:SF1 WIDE AWAKE WIDE AWAKE HELRO|EnsemblGenome=HelroG93365|UniProtKB=T1G8V4 T1G8V4 20217501 PTHR10024:SF344 SYNAPTOTAGMIN SYNAPTOTAGMIN-7 cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;phosphatidylserine binding#GO:0001786;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;protein binding#GO:0005515;clathrin binding#GO:0030276;lipid binding#GO:0008289;ion binding#GO:0043167;phospholipid binding#GO:0005543;SNARE binding#GO:0000149 vesicle fusion#GO:0006906;cellular localization#GO:0051641;synaptic vesicle cycle#GO:0099504;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;regulated exocytosis#GO:0045055;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;secretion#GO:0046903;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;signal release#GO:0023061;vesicle organization#GO:0016050;calcium-ion regulated exocytosis#GO:0017156;signaling#GO:0023052;cell-cell signaling#GO:0007267;synaptic vesicle exocytosis#GO:0016079;organelle fusion#GO:0048284;secretion by cell#GO:0032940;neurotransmitter secretion#GO:0007269;trans-synaptic signaling#GO:0099537;vesicle-mediated transport#GO:0016192;cell communication#GO:0007154;cellular component organization#GO:0016043;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;membrane fusion#GO:0061025;signal release from synapse#GO:0099643;exocytosis#GO:0006887;organelle organization#GO:0006996;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;export from cell#GO:0140352;vesicle-mediated transport in synapse#GO:0099003 synapse#GO:0045202;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;axon#GO:0030424;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;neuron projection#GO:0043005;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;transport vesicle#GO:0030133;cell projection#GO:0042995;secretory vesicle#GO:0099503;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG192123|UniProtKB=T1FTL5 T1FTL5 20212162 PTHR47827:SF3 AHD DOMAIN-CONTAINING PROTEIN AF-9 ANC1 HOMOLOGY DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;protein-containing complex binding#GO:0044877;histone binding#GO:0042393;binding#GO:0005488;chromatin binding#GO:0003682;modification-dependent protein binding#GO:0140030 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;transcription elongation factor complex#GO:0008023;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG170997|UniProtKB=T1F3P0 T1F3P0 20203439 PTHR11785:SF528 AMINO ACID TRANSPORTER AMINO ACID TRANSPORTER PROTEIN JHI-21 L-amino acid transmembrane transporter activity#GO:0015179;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;amino acid transport#GO:0006865;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;nitrogen compound transport#GO:0071705;organic acid transmembrane transport#GO:1903825;carboxylic acid transport#GO:0046942;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039 transporter#PC00227 HELRO|EnsemblGenome=HelroG90604|UniProtKB=T1G7T4 T1G7T4 20217131 PTHR12027:SF101 WNT RELATED PROTEIN WNT-4 molecular function activator activity#GO:0140677;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;protein binding#GO:0005515;cytokine activity#GO:0005125;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;neurogenesis#GO:0022008;developmental process#GO:0032502;multicellular organism development#GO:0007275;cell communication#GO:0007154;cell fate commitment#GO:0045165;cell-cell signaling by wnt#GO:0198738;nervous system development#GO:0007399;cellular process#GO:0009987;regulation of biological process#GO:0050789;system development#GO:0048731;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;cell-cell signaling#GO:0007267;signaling#GO:0023052;canonical Wnt signaling pathway#GO:0060070;Wnt signaling pathway#GO:0016055 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Cadherin signaling pathway#P00012>Wnt#P00474 HELRO|EnsemblGenome=HelroG136124|UniProtKB=T1EIC2 T1EIC2 20196322 PTHR11106:SF27 GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED MACRO DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG115679|UniProtKB=T1EG99 T1EG99 20195601 PTHR19850:SF36 GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5 molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591;signaling receptor complex adaptor activity#GO:0030159;protein-macromolecule adaptor activity#GO:0030674 response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;response to organic cyclic compound#GO:0014070;signal transduction#GO:0007165;cellular response to endogenous stimulus#GO:0071495;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;cellular response to organic substance#GO:0071310;response to organonitrogen compound#GO:0010243;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to nitrogen compound#GO:1901699;response to nitrogen compound#GO:1901698;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to oxygen-containing compound#GO:1901701;response to endogenous stimulus#GO:0009719;response to chemical#GO:0042221;dopamine receptor signaling pathway#GO:0007212;cellular response to organonitrogen compound#GO:0071417;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cellular response to organic cyclic compound#GO:0071407;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;side of membrane#GO:0098552;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;extrinsic component of membrane#GO:0019898 heterotrimeric G-protein#PC00117;G-protein#PC00020 5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;5HT4 type receptor mediated signaling pathway#P04376>G-protein#P04430;Histamine H2 receptor mediated signaling pathway#P04386>G-Protein#P04490;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;Beta1 adrenergic receptor signaling pathway#P04377>G-Protein#P04436;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Gbeta5L#P00748;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Opioid prodynorphin pathway#P05916>G-protein#P06002;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>Gbeta#P05930;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Enkephalin release#P05913>G-Protein (i)#P05974;PI3 kinase pathway#P00048>Gbetagamma#P01188;Enkephalin release#P05913>G-Protein (s)#P05977;Opioid proenkephalin pathway#P05915>G-protein#P05994;Beta3 adrenergic receptor signaling pathway#P04379>G-Protein#P04448;Gonadotropin-releasing hormone receptor pathway#P06664>Gbeta#P06769;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Beta2 adrenergic receptor signaling pathway#P04378>G-Protein#P04443 HELRO|EnsemblGenome=HelroG77242|UniProtKB=T1G2U9 T1G2U9 20215397 PTHR23339:SF27 TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE PROTEIN-TYROSINE-PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 regulation of mitotic cell cycle phase transition#GO:1901990;microtubule cytoskeleton organization#GO:0000226;regulation of cell cycle phase transition#GO:1901987;positive regulation of cell cycle#GO:0045787;cellular component organization#GO:0016043;regulation of cell division#GO:0051302;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;regulation of cell cycle process#GO:0010564;regulation of biological process#GO:0050789;positive regulation of cell division#GO:0051781;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;positive regulation of cell cycle process#GO:0090068;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of cell cycle#GO:0051726;regulation of cytokinesis#GO:0032465;regulation of mitotic cell cycle#GO:0007346;positive regulation of biological process#GO:0048518 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG99003|UniProtKB=T1G9Q5 T1G9Q5 20217801 PTHR11920:SF501 GUANYLYL CYCLASE GUANYLATE CYCLASE 32E adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG75866|UniProtKB=T1G2B6 T1G2B6 20215214 PTHR23048:SF33 MYOSIN LIGHT CHAIN 1, 3 MYOSIN LIGHT CHAIN ALKALI supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;supramolecular fiber#GO:0099512;supramolecular polymer#GO:0099081;myosin complex#GO:0016459;contractile fiber#GO:0043292;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG170433|UniProtKB=T1F321 T1F321 20203220 PTHR47032:SF1 UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG81006|UniProtKB=T1G481 T1G481 20215879 PTHR14453:SF67 PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN POLY [ADP-RIBOSE] POLYMERASE molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;protein-macromolecule adaptor activity#GO:0030674 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG156952|UniProtKB=T1EM38 T1EM38 20197638 PTHR23427:SF1 SURFEIT LOCUS PROTEIN SURFEIT LOCUS PROTEIN 4 endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cellular process#GO:0009987;Golgi organization#GO:0007030;organelle organization#GO:0006996 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG132487|UniProtKB=T1EHY8 T1EHY8 20196188 PTHR11097:SF14 EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN EXOSOME COMPLEX COMPONENT RRP45 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159;mRNA 3'-UTR binding#GO:0003730 negative regulation of gene expression#GO:0010629;tRNA metabolic process#GO:0006399;cellular component biogenesis#GO:0044085;regulation of catabolic process#GO:0009894;heterocycle catabolic process#GO:0046700;regulation of nitrogen compound metabolic process#GO:0051171;rRNA processing#GO:0006364;positive regulation of cellular metabolic process#GO:0031325;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA destabilization#GO:0050779;modification-dependent macromolecule catabolic process#GO:0043632;regulation of biological process#GO:0050789;ncRNA metabolic process#GO:0034660;mRNA metabolic process#GO:0016071;regulation of biological quality#GO:0065008;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;snRNA 3'-end processing#GO:0034472;ribosome biogenesis#GO:0042254;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;cellular component organization or biogenesis#GO:0071840;positive regulation of mRNA catabolic process#GO:0061014;regulation of cellular process#GO:0050794;rRNA metabolic process#GO:0016072;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of catabolic process#GO:0009896;mRNA destabilization#GO:0061157;nucleobase-containing compound catabolic process#GO:0034655;polyadenylation-dependent ncRNA catabolic process#GO:0043634;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323;positive regulation of nitrogen compound metabolic process#GO:0051173;cellular aromatic compound metabolic process#GO:0006725;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of mRNA stability#GO:0043488;regulation of mRNA catabolic process#GO:0061013;RNA metabolic process#GO:0016070;positive regulation of cellular catabolic process#GO:0031331;RNA processing#GO:0006396;biosynthetic process#GO:0009058;cellular nitrogen compound catabolic process#GO:0044270;positive regulation of metabolic process#GO:0009893;organic cyclic compound metabolic process#GO:1901360;mRNA catabolic process#GO:0006402;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;snRNA processing#GO:0016180;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;maturation of 5.8S rRNA#GO:0000460;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;positive regulation of mRNA metabolic process#GO:1903313;heterocycle metabolic process#GO:0046483;snRNA metabolic process#GO:0016073;macromolecule biosynthetic process#GO:0009059;negative regulation of biosynthetic process#GO:0009890;RNA 3'-end processing#GO:0031123;cellular biosynthetic process#GO:0044249;nuclear-transcribed mRNA catabolic process#GO:0000956;organic substance biosynthetic process#GO:1901576;regulation of cellular catabolic process#GO:0031329;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;regulation of cellular biosynthetic process#GO:0031326;aromatic compound catabolic process#GO:0019439;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;ribonucleoprotein complex biogenesis#GO:0022613;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;positive regulation of RNA metabolic process#GO:0051254 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513;exosome (RNase complex)#GO:0000178 RNA metabolism protein#PC00031;exoribonuclease#PC00099 HELRO|EnsemblGenome=HelroG191687|UniProtKB=T1FT75 T1FT75 20212022 PTHR24056:SF400 CELL DIVISION PROTEIN KINASE KINASE, PUTATIVE-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG119855|UniProtKB=T1EGN8 T1EGN8 20195738 PTHR11537:SF254 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG193911|UniProtKB=T1FVG9 T1FVG9 20212815 PTHR46785:SF1 VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3B VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3B HELRO|EnsemblGenome=HelroG190022|UniProtKB=T1FRL7 T1FRL7 20211464 PTHR42757:SF32 IGLON FAMILY OF IMMUNOGLOBULIN SUPERFAMILY-RELATED PROTEIN AMALGAM defense/immunity protein#PC00090;immunoglobulin#PC00123 HELRO|EnsemblGenome=HelroG132380|UniProtKB=T1EHY3 T1EHY3 20196183 PTHR10663:SF402 GUANYL-NUCLEOTIDE EXCHANGE FACTOR MIP16918P guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG194907|UniProtKB=T1FWJ8 T1FWJ8 20213193 PTHR11759:SF1 40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11 40S RIBOSOMAL PROTEIN S14 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;small ribosomal subunit#GO:0015935;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG193618|UniProtKB=T1FV68 T1FV68 20212714 PTHR25462:SF305 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG160971|UniProtKB=T1EQX9 T1EQX9 20198979 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG160844|UniProtKB=T1EQT4 T1EQT4 20198934 PTHR23292:SF6 LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR FI16602P1-RELATED cation binding#GO:0043169;metal ion binding#GO:0046872;ion binding#GO:0043167;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;binding#GO:0005488;transition metal ion binding#GO:0046914 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG146924|UniProtKB=T1EJV6 T1EJV6 20196856 PTHR47611:SF3 HAT DIMERISATION DOMAIN, C-TERMINAL HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185252|UniProtKB=T1FMK2 T1FMK2 20210051 PTHR19957:SF411 SYNTAXIN LD23667P molecular adaptor activity#GO:0060090;protein binding#GO:0005515;SNAP receptor activity#GO:0005484;binding#GO:0005488;SNARE binding#GO:0000149;protein-macromolecule adaptor activity#GO:0030674 vesicle fusion#GO:0006906;cellular localization#GO:0051641;organelle localization#GO:0051640;macromolecule localization#GO:0033036;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;membrane fusion#GO:0061025;establishment of localization#GO:0051234;organelle organization#GO:0006996;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;vesicle organization#GO:0016050;intracellular transport#GO:0046907;organelle fusion#GO:0048284 presynapse#GO:0098793;membrane protein complex#GO:0098796;synapse#GO:0045202;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;SNARE complex#GO:0031201;cell junction#GO:0030054;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;secretory vesicle#GO:0099503 SNARE protein#PC00034;membrane traffic protein#PC00150 Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072;Parkinson disease#P00049>Syntaxin#P01215 HELRO|EnsemblGenome=HelroG156455|UniProtKB=T1ELW9 T1ELW9 20197569 PTHR11668:SF510 SERINE/THREONINE PROTEIN PHOSPHATASE SERINE_THREONINE-PROTEIN PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG184836|UniProtKB=T1FM25 T1FM25 20209874 PTHR11118:SF1 RNA-SPLICING LIGASE RTCB HOMOLOG RNA-SPLICING LIGASE RTCB HOMOLOG catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;tRNA metabolic process#GO:0006399;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;tRNA splicing, via endonucleolytic cleavage and ligation#GO:0006388;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 DNA replication#P00017>RFC#P00529 HELRO|EnsemblGenome=HelroG162405|UniProtKB=T1ESM0 T1ESM0 20199570 PTHR31964:SF113 ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE SUPERFAMILY PROTEIN USPA DOMAIN-CONTAINING PROTEIN metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG147316|UniProtKB=T1EJZ2 T1EJZ2 20196892 PTHR23235:SF174 KRUEPPEL-LIKE TRANSCRIPTION FACTOR CABUT, ISOFORM A sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG138545|UniProtKB=T1EIV4 T1EIV4 20196504 PTHR13864:SF10 T-CELL ACUTE LYMPHOCYTIC LEUKEMIA/STEM CELL LEUKEMIA-RELATED HELIX-LOOP-HELIX PROTEIN 2 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG167350|UniProtKB=T1EZA5 T1EZA5 20201905 PTHR45713:SF15 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175937|UniProtKB=T1F9X7 T1F9X7 20205626 PTHR35450:SF2 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193825|UniProtKB=T1FVE3 T1FVE3 20212789 PTHR23509:SF10 PA-PL1 PHOSPHOLIPASE FAMILY LD21067P hydrolase activity#GO:0016787;lipase activity#GO:0016298;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0004620;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 phospholipase#PC00186;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG70877|UniProtKB=T1G0D4 T1G0D4 20214532 PTHR11909:SF20 CASEIN KINASE-RELATED CASEIN KINASE I ISOFORM ALPHA transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Hedgehog signaling pathway#P00025>Casein kinase I#P00681;Parkinson disease#P00049>Casein kinase I#P01242 HELRO|EnsemblGenome=HelroG191122|UniProtKB=T1FSM2 T1FSM2 20211819 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG93398|UniProtKB=T1G8V5 T1G8V5 20217502 PTHR12161:SF5 IST1 FAMILY MEMBER IST1 HOMOLOG localization#GO:0051179;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;cellular process#GO:0009987;macromolecule localization#GO:0033036;protein localization#GO:0008104 HELRO|EnsemblGenome=HelroG63375|UniProtKB=T1FXF0 T1FXF0 20213498 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG175127|UniProtKB=T1F8W2 T1F8W2 20205261 PTHR23149:SF9 G PATCH DOMAIN CONTAINING PROTEIN G PATCH DOMAIN-CONTAINING PROTEIN 4 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG65498|UniProtKB=T1FY88 T1FY88 20213786 PTHR10858:SF30 DEOXYRIBONUCLEASE II CELL-DEATH-RELATED NUCLEASE 7 hydrolase activity, acting on ester bonds#GO:0016788;DNA endonuclease activity#GO:0004520;nuclease activity#GO:0004518;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;execution phase of apoptosis#GO:0097194;heterocycle catabolic process#GO:0046700;macromolecule metabolic process#GO:0043170;DNA catabolic process#GO:0006308;cellular metabolic process#GO:0044237;programmed cell death#GO:0012501;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular nitrogen compound catabolic process#GO:0044270;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;cellular component disassembly#GO:0022411;aromatic compound catabolic process#GO:0019439;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;apoptotic process#GO:0006915;cell death#GO:0008219;organic cyclic compound catabolic process#GO:1901361;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;nucleobase-containing compound catabolic process#GO:0034655;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;cellular catabolic process#GO:0044248 endodeoxyribonuclease#PC00093 HELRO|EnsemblGenome=HelroG195047|UniProtKB=T1FWP8 T1FWP8 20213243 PTHR14963:SF7 RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED RHO GTPASE-ACTIVATING PROTEIN 19 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG84863|UniProtKB=T1G5P8 T1G5P8 20216395 PTHR13303:SF0 PREFOLDIN SUBUNIT 2 PREFOLDIN SUBUNIT 2 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG192276|UniProtKB=T1FTS4 T1FTS4 20212221 PTHR10736:SF65 BESTROPHIN BESTROPHIN 1, ISOFORM C-RELATED inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;channel activity#GO:0015267 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG167340|UniProtKB=T1EZA0 T1EZA0 20201900 PTHR31180:SF2 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 107-RELATED CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 107 supramolecular complex#GO:0099080;axoneme#GO:0005930;cytoplasmic microtubule#GO:0005881;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;ciliary plasm#GO:0097014;plasma membrane bounded cell projection cytoplasm#GO:0032838;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929;microtubule#GO:0005874;axonemal microtubule#GO:0005879 HELRO|EnsemblGenome=HelroG165415|UniProtKB=T1EWR2 T1EWR2 20201012 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN SI:DKEY-17M8.2 HELRO|EnsemblGenome=HelroG142891|UniProtKB=T1EJ81 T1EJ81 20196631 PTHR23226:SF139 ZINC FINGER AND SCAN DOMAIN-CONTAINING FI01106P-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG194478|UniProtKB=T1FW36 T1FW36 20213032 PTHR23504:SF1 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10 GH21943P-RELATED secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG75388|UniProtKB=T1G245 T1G245 20215143 PTHR11532:SF62 PROTEASE M14 CARBOXYPEPTIDASE CARBOXYPEPTIDASE D metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metallocarboxypeptidase activity#GO:0004181;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;carboxypeptidase activity#GO:0004180 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG162163|UniProtKB=T1ESA9 T1ESA9 20199459 PTHR47018:SF4 CXC DOMAIN-CONTAINING PROTEIN-RELATED SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG177817|UniProtKB=T1FCB5 T1FCB5 20206464 PTHR43591:SF109 METHYLTRANSFERASE METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG188352|UniProtKB=T1FPW8 T1FPW8 20210865 PTHR13817:SF170 TITIN PROTEIN-TYROSINE-PHOSPHATASE structural protein#PC00211 HELRO|EnsemblGenome=HelroG162766|UniProtKB=T1ET39 T1ET39 20199739 PTHR10725:SF78 THAP DOMAIN-CONTAINING PROTEIN 9 DNA TRANSPOSASE THAP9 HELRO|EnsemblGenome=HelroG86442|UniProtKB=T1G6C3 T1G6C3 20216620 PTHR19818:SF157 ZINC FINGER PROTEIN ZIC AND GLI C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG185484|UniProtKB=T1FMV8 T1FMV8 20210157 PTHR11599:SF15 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT ALPHA TYPE-7-1-RELATED macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protease#PC00190;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489;Parkinson disease#P00049>20S proteasome#P01227 HELRO|EnsemblGenome=HelroG175037|UniProtKB=T1F8R8 T1F8R8 20205217 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG191565|UniProtKB=T1FT32 T1FT32 20211979 PTHR22969:SF17 IKB KINASE INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;peptidyl-amino acid modification#GO:0018193;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;nitrogen compound metabolic process#GO:0006807;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Apoptosis signaling pathway#P00006>IKK#P00313 HELRO|EnsemblGenome=HelroG191009|UniProtKB=T1FSH8 T1FSH8 20211775 PTHR11787:SF4 RAB GDP-DISSOCIATION INHIBITOR CHM, RAB ESCORT PROTEIN 1 localization#GO:0051179;establishment of localization#GO:0051234;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;transport#GO:0006810;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;vesicle-mediated transport#GO:0016192;cellular metabolic process#GO:0044237;cellular process#GO:0009987;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG194280|UniProtKB=T1FVW2 T1FVW2 20212958 PTHR16071:SF2 CHROMOSOME 1 OPEN READING FRAME 112 FIGNL1-INTERACTING REGULATOR OF RECOMBINATION AND MITOSIS HELRO|EnsemblGenome=HelroG78931|UniProtKB=T1G3H4 T1G3H4 20215622 PTHR44554:SF1 LRP2-BINDING PROTEIN LRP2-BINDING PROTEIN HELRO|EnsemblGenome=HelroG189281|UniProtKB=T1FQX0 T1FQX0 20211217 PTHR24034:SF148 EGF-LIKE DOMAIN-CONTAINING PROTEIN RE58433P extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG171406|UniProtKB=T1F486 T1F486 20203635 PTHR10877:SF183 POLYCYSTIN FAMILY MEMBER AT14535P-RELATED ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG180112|UniProtKB=T1FFH4 T1FFH4 20207573 PTHR10782:SF94 ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN SUPPRESSOR OF VARIEGATION 2-10, ISOFORM I molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;SUMO transferase activity#GO:0019789;protein-macromolecule adaptor activity#GO:0030674;ubiquitin-like protein ligase activity#GO:0061659;SUMO ligase activity#GO:0061665;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;regulation of DNA-templated transcription#GO:0006355;macromolecule metabolic process#GO:0043170;regulation of nitrogen compound metabolic process#GO:0051171;protein sumoylation#GO:0016925;regulation of transcription by RNA polymerase II#GO:0006357;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;regulation of RNA biosynthetic process#GO:2001141;post-translational protein modification#GO:0043687;regulation of RNA metabolic process#GO:0051252;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Interferon-gamma signaling pathway#P00035>PIAS#P00958 HELRO|EnsemblGenome=HelroG72426|UniProtKB=T1G0Z8 T1G0Z8 20214746 PTHR45752:SF156 LEUCINE-RICH REPEAT-CONTAINING RAS SUPPRESSOR PROTEIN 1 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG68816|UniProtKB=T1FZK0 T1FZK0 20214248 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG78986|UniProtKB=T1G3H8 T1G3H8 20215626 PTHR24410:SF23 HL07962P-RELATED BTB DOMAIN-CONTAINING PROTEIN-RELATED defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG161590|UniProtKB=T1ERN8 T1ERN8 20199238 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186803|UniProtKB=T1FP38 T1FP38 20210585 PTHR15592:SF27 MATRIN 3/NUCLEAR PROTEIN 220-RELATED HEPHAESTUS, ISOFORM Y nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nitrogen compound metabolic process#GO:0051171;regulation of biosynthetic process#GO:0009889;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG81061|UniProtKB=T1G483 T1G483 20215881 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174274|UniProtKB=T1F7X3 T1F7X3 20204922 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77285|UniProtKB=T1G2V7 T1G2V7 20215405 PTHR12560:SF58 LONGEVITY ASSURANCE FACTOR 1 LAG1 CERAMIDE SYNTHASE 1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;N-acyltransferase activity#GO:0016410 lipid metabolic process#GO:0006629;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;membrane lipid biosynthetic process#GO:0046467;sphingolipid metabolic process#GO:0006665;ceramide metabolic process#GO:0006672;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;membrane lipid metabolic process#GO:0006643;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;ceramide biosynthetic process#GO:0046513;cellular lipid metabolic process#GO:0044255;amide metabolic process#GO:0043603;sphingolipid biosynthetic process#GO:0030148;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 transferase#PC00220;metabolite interconversion enzyme#PC00262 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HELRO|EnsemblGenome=HelroG172506|UniProtKB=T1F5F3 T1F5F3 20204052 PTHR45977:SF4 TARGET OF ERK KINASE MPK-1 RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 HELRO|EnsemblGenome=HelroG164372|UniProtKB=T1EVC0 T1EVC0 20200520 PTHR34094:SF1 FAMILY NOT NAMED PROTEIN FAM185A HELRO|EnsemblGenome=HelroG98479|UniProtKB=T1G9N0 T1G9N0 20217776 PTHR45619:SF12 SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 cell cycle#GO:0007049;mitotic cell cycle#GO:0000278;cellular process#GO:0009987 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 p53 pathway#P00059>PP2A#P04630;Wnt signaling pathway#P00057>PP2A#P01438;p53 pathway feedback loops 2#P04398>PP2A-C#P04659;p53 pathway by glucose deprivation#P04397>PP2A-C#P04643;FGF signaling pathway#P00021>PP2A#P00629;EGF receptor signaling pathway#P00018>PP2A#P00547 HELRO|EnsemblGenome=HelroG62653|UniProtKB=T1FX31 T1FX31 20213379 PTHR11347:SF226 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE DUAL SPECIFICITY CALCIUM_CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric diester hydrolase activity#GO:0008081;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;cAMP-mediated signaling#GO:0019933;signaling#GO:0023052;cyclic-nucleotide-mediated signaling#GO:0019935 phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG115427|UniProtKB=T1EG80 T1EG80 20195582 PTHR43084:SF1 PERSULFIDE DIOXYGENASE ETHE1 PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213 sulfur compound metabolic process#GO:0006790;nitrogen compound metabolic process#GO:0006807;peptide metabolic process#GO:0006518;cellular modified amino acid metabolic process#GO:0006575;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular process#GO:0009987;glutathione metabolic process#GO:0006749;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 oxygenase#PC00177;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG163130|UniProtKB=T1ETP3 T1ETP3 20199943 PTHR24034:SF89 EGF-LIKE DOMAIN-CONTAINING PROTEIN COMPLEMENT COMPONENT C1Q RECEPTOR extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG178890|UniProtKB=T1FDV1 T1FDV1 20207000 PTHR24104:SF50 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG184783|UniProtKB=T1FLZ6 T1FLZ6 20209845 PTHR46579:SF2 F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188699|UniProtKB=T1FQ98 T1FQ98 20210995 PTHR31179:SF7 RAB GTPASE-BINDING EFFECTOR PROTEIN FYVE-TYPE DOMAIN-CONTAINING PROTEIN membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG75876|UniProtKB=T1G2B9 T1G2B9 20215217 PTHR13166:SF7 PROTEIN C6ORF149 LYR MOTIF-CONTAINING PROTEIN 4 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;iron-sulfur cluster assembly#GO:0016226;cellular component organization#GO:0016043;cellular process#GO:0009987 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG68144|UniProtKB=T1FZA9 T1FZA9 20214157 PTHR47537:SF2 CUBILIN CUBILIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG86942|UniProtKB=T1G6J6 T1G6J6 20216693 PTHR19143:SF444 FIBRINOGEN/TENASCIN/ANGIOPOEITIN PROTEIN SCABROUS external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG72072|UniProtKB=T1G0V0 T1G0V0 20214698 PTHR12984:SF3 SCY1-RELATED S/T PROTEIN KINASE-LIKE N-TERMINAL KINASE-LIKE PROTEIN non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG177986|UniProtKB=T1FCK6 T1FCK6 20206555 PTHR13194:SF18 COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30 COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL protein binding#GO:0005515;unfolded protein binding#GO:0051082;binding#GO:0005488 aerobic respiration#GO:0009060;cellular respiration#GO:0045333;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrial electron transport, NADH to ubiquinone#GO:0006120;aerobic electron transport chain#GO:0019646;generation of precursor metabolites and energy#GO:0006091;protein-containing complex assembly#GO:0065003;electron transport chain#GO:0022900;ATP synthesis coupled electron transport#GO:0042773;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular process#GO:0009987;energy derivation by oxidation of organic compounds#GO:0015980;cellular component organization or biogenesis#GO:0071840;mitochondrial ATP synthesis coupled electron transport#GO:0042775;mitochondrial respiratory chain complex I assembly#GO:0032981;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;respiratory electron transport chain#GO:0022904;oxidative phosphorylation#GO:0006119;mitochondrion organization#GO:0007005;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG180844|UniProtKB=T1FGB9 T1FGB9 20207868 PTHR48027:SF18 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED HELRO|EnsemblGenome=HelroG80591|UniProtKB=T1G423 T1G423 20215821 PTHR48041:SF116 ABC TRANSPORTER G FAMILY MEMBER 28 PROTEIN BROWN transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG189420|UniProtKB=T1FR17 T1FR17 20211264 PTHR45976:SF1 ARMADILLO SEGMENT POLARITY PROTEIN ARMADILLO SEGMENT POLARITY PROTEIN phosphatase binding#GO:0019902;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;nuclear receptor binding#GO:0016922;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;cell adhesion molecule binding#GO:0050839;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;enzyme binding#GO:0019899;protein binding#GO:0005515;protein phosphatase binding#GO:0019903;transcription factor binding#GO:0008134;DNA-binding transcription factor binding#GO:0140297 positive regulation of nitrogen compound metabolic process#GO:0051173;signal transduction#GO:0007165;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;cell-cell signaling#GO:0007267;signaling#GO:0023052;canonical Wnt signaling pathway#GO:0060070;Wnt signaling pathway#GO:0016055;cellular response to stimulus#GO:0051716;regulation of DNA-templated transcription#GO:0006355;cell-cell adhesion#GO:0098609;cell communication#GO:0007154;cell adhesion#GO:0007155;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;cell-cell signaling by wnt#GO:0198738;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane protein complex#GO:0098796;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cell-cell junction#GO:0005911;anchoring junction#GO:0070161;plasma membrane protein complex#GO:0098797;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;extrinsic component of membrane#GO:0019898;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;adherens junction#GO:0005912;plasma membrane#GO:0005886 Cadherin signaling pathway#P00012>betacatenin#P00463;p53 pathway feedback loops 2#P04398>beta-catenin#P04670;Wnt signaling pathway#P00057>Beta-Catenin#P01432;Angiogenesis#P00005>beta catenin#P00187;Alzheimer disease-presenilin pathway#P00004>beta-catenin#P00156 HELRO|EnsemblGenome=HelroG178679|UniProtKB=T1FDK2 T1FDK2 20206901 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185535|UniProtKB=T1FMX9 T1FMX9 20210178 PTHR24345:SF93 SERINE/THREONINE-PROTEIN KINASE PLK SERINE_THREONINE-PROTEIN KINASE PLK1 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;mitotic spindle organization#GO:0007052;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;cell cycle#GO:0007049;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;spindle organization#GO:0007051;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047 supramolecular complex#GO:0099080;spindle pole#GO:0000922;microtubule organizing center#GO:0005815;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;kinetochore#GO:0000776;condensed chromosome, centromeric region#GO:0000779;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;centrosome#GO:0005813;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;chromosome#GO:0005694;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;chromosomal region#GO:0098687;cytoskeleton#GO:0005856;spindle#GO:0005819 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG186175|UniProtKB=T1FNR8 T1FNR8 20210465 PTHR11726:SF10 60S RIBOSOMAL PROTEIN L10 LARGE RIBOSOMAL SUBUNIT PROTEIN UL16 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;organelle assembly#GO:0070925;protein-RNA complex assembly#GO:0022618;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;ribosomal large subunit assembly#GO:0000027;ribonucleoprotein complex biogenesis#GO:0022613;protein-RNA complex organization#GO:0071826;ribosome biogenesis#GO:0042254;non-membrane-bounded organelle assembly#GO:0140694 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG177385|UniProtKB=T1FBL5 T1FBL5 20206214 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG68472|UniProtKB=T1FZF2 T1FZF2 20214200 PTHR24247:SF191 5-HYDROXYTRYPTAMINE RECEPTOR MUSCARINIC ACETYLCHOLINE RECEPTOR, B-TYPE, ISOFORM A signaling receptor activity#GO:0038023;G protein-coupled amine receptor activity#GO:0008227;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 response to organic substance#GO:0010033;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to nitrogen compound#GO:1901699;response to nitrogen compound#GO:1901698;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to oxygen-containing compound#GO:1901701;chemical synaptic transmission#GO:0007268;response to chemical#GO:0042221;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;synaptic signaling#GO:0099536;G protein-coupled receptor signaling pathway#GO:0007186;cell-cell signaling#GO:0007267;signaling#GO:0023052;acetylcholine receptor signaling pathway#GO:0095500 synapse#GO:0045202;somatodendritic compartment#GO:0036477;neuron projection#GO:0043005;cell junction#GO:0030054;dendrite#GO:0030425;cell projection#GO:0042995;cell periphery#GO:0071944;dendritic tree#GO:0097447;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GqPCR#P00730 HELRO|EnsemblGenome=HelroG170233|UniProtKB=T1F2T3 T1F2T3 20203132 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG65716|UniProtKB=T1FYB8 T1FYB8 20213816 PTHR10891:SF989 EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN EF-HAND DOMAIN-CONTAINING PROTEIN calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG175920|UniProtKB=T1F9W2 T1F9W2 20205611 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG85598|UniProtKB=T1G604 T1G604 20216501 PTHR45832:SF22 SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED HELRO|EnsemblGenome=HelroG183600|UniProtKB=T1FJW8 T1FJW8 20209117 PTHR24075:SF5 SEC63 DOMAIN-CONTAINING U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE catalytic activity, acting on RNA#GO:0140098;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG188291|UniProtKB=T1FPU2 T1FPU2 20210839 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;chloride transmembrane transporter activity#GO:0015108;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;inorganic anion transmembrane transport#GO:0098661;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic anion transport#GO:0006820;chloride transport#GO:0006821;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;inorganic anion transport#GO:0015698 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG79999|UniProtKB=T1G3W3 T1G3W3 20215761 PTHR12865:SF1 PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301;lipid kinase activity#GO:0001727 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;Golgi organization#GO:0007030;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycerolipid biosynthetic process#GO:0045017;endomembrane system organization#GO:0010256;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;cellular component organization or biogenesis#GO:0071840;endosome organization#GO:0007032;glycerolipid metabolic process#GO:0046486;organelle organization#GO:0006996;glycerophospholipid biosynthetic process#GO:0046474;vesicle organization#GO:0016050;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 trans-Golgi network#GO:0005802;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;organelle subcompartment#GO:0031984;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791;plasma membrane#GO:0005886 kinase#PC00137 HELRO|EnsemblGenome=HelroG192677|UniProtKB=T1FU66 T1FU66 20212362 PTHR31921:SF1 PROTEIN DPCD PROTEIN DPCD HELRO|EnsemblGenome=HelroG178226|UniProtKB=T1FCY7 T1FCY7 20206686 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165054|UniProtKB=T1EW77 T1EW77 20200827 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG127610|UniProtKB=T1EHF8 T1EHF8 20196008 PTHR24340:SF41 HOMEOBOX PROTEIN NKX MUSCLE-SPECIFIC HOMEOBOX PROTEIN TINMAN-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG92277|UniProtKB=T1G8D8 T1G8D8 20217335 PTHR12892:SF11 FGF RECEPTOR ACTIVATING PROTEIN 1 POST-GPI ATTACHMENT TO PROTEINS FACTOR 2 lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;phospholipid biosynthetic process#GO:0008654;macromolecule modification#GO:0043412;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycolipid metabolic process#GO:0006664;protein modification process#GO:0036211;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;glycerolipid biosynthetic process#GO:0045017;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;organic substance biosynthetic process#GO:1901576;liposaccharide metabolic process#GO:1903509;cellular process#GO:0009987;GPI anchor metabolic process#GO:0006505;membrane lipid biosynthetic process#GO:0046467;lipoprotein biosynthetic process#GO:0042158;primary metabolic process#GO:0044238;GPI anchor biosynthetic process#GO:0006506;carbohydrate derivative biosynthetic process#GO:1901137;membrane lipid metabolic process#GO:0006643;glycerophospholipid biosynthetic process#GO:0046474;glycolipid biosynthetic process#GO:0009247;organophosphate metabolic process#GO:0019637;lipoprotein metabolic process#GO:0042157;cellular lipid metabolic process#GO:0044255 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG193359|UniProtKB=T1FUW9 T1FUW9 20212615 PTHR21136:SF168 SNARE PROTEINS VESICLE-ASSOCIATED MEMBRANE PROTEIN 9 SNARE protein#PC00034 Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072 HELRO|EnsemblGenome=HelroG165179|UniProtKB=T1EWE1 T1EWE1 20200891 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG72267|UniProtKB=T1G0X8 T1G0X8 20214726 PTHR24031:SF727 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX47-RELATED RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG185519|UniProtKB=T1FMX3 T1FMX3 20210172 PTHR12704:SF2 TRANS-GOLGI PROTEIN GMX33 GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON HELRO|EnsemblGenome=HelroG157392|UniProtKB=T1EMA7 T1EMA7 20197707 PTHR23281:SF18 MERLIN/MOESIN/EZRIN/RADIXIN MOESIN_EZRIN_RADIXIN HOMOLOG 1 cell adhesion molecule binding#GO:0050839;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;actin binding#GO:0003779;binding#GO:0005488 regulation of anatomical structure morphogenesis#GO:0022603;regulation of organelle organization#GO:0033043;positive regulation of transport#GO:0051050;regulation of localization#GO:0032879;regulation of cellular component organization#GO:0051128;regulation of cellular localization#GO:0060341;regulation of vesicle-mediated transport#GO:0060627;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of cell shape#GO:0008360;regulation of transport#GO:0051049;regulation of biological quality#GO:0065008;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;regulation of organelle assembly#GO:1902115;biological regulation#GO:0065007;positive regulation of protein localization#GO:1903829;positive regulation of biological process#GO:0048518;regulation of protein localization#GO:0032880 actin-based cell projection#GO:0098858;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;filopodium#GO:0030175 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG157380|UniProtKB=T1EMA6 T1EMA6 20197706 PTHR12886:SF0 PIG-M MANNOSYLTRANSFERASE GPI MANNOSYLTRANSFERASE 1 mannosyltransferase activity#GO:0000030;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;phospholipid biosynthetic process#GO:0008654;macromolecule modification#GO:0043412;phosphatidylinositol biosynthetic process#GO:0006661;organophosphate biosynthetic process#GO:0090407;glycolipid metabolic process#GO:0006664;protein modification process#GO:0036211;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;glycerolipid biosynthetic process#GO:0045017;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;organic substance biosynthetic process#GO:1901576;liposaccharide metabolic process#GO:1903509;cellular process#GO:0009987;membrane lipid biosynthetic process#GO:0046467;GPI anchor metabolic process#GO:0006505;lipoprotein biosynthetic process#GO:0042158;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;GPI anchor biosynthetic process#GO:0006506;membrane lipid metabolic process#GO:0006643;glycerophospholipid biosynthetic process#GO:0046474;glycolipid biosynthetic process#GO:0009247;organophosphate metabolic process#GO:0019637;lipoprotein metabolic process#GO:0042157;cellular lipid metabolic process#GO:0044255 cytoplasm#GO:0005737;endoplasmic reticulum protein-containing complex#GO:0140534;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;mannosyltransferase complex#GO:0031501;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG73033|UniProtKB=T1G190 T1G190 20214838 PTHR11767:SF102 INWARD RECTIFIER POTASSIUM CHANNEL INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of localization#GO:0032879;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;import across plasma membrane#GO:0098739;regulation of transport#GO:0051049;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;regulation of monoatomic ion transport#GO:0043269;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;potassium ion transport#GO:0006813;potassium ion import across plasma membrane#GO:1990573 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG163097|UniProtKB=T1ETN2 T1ETN2 20199932 PTHR15577:SF2 ZINC FINGER CONTAINING PROTEIN ZINC FINGER PROTEIN 318 positive regulation of nitrogen compound metabolic process#GO:0051173;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of RNA metabolic process#GO:0051253;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of cellular metabolic process#GO:0031325;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;negative regulation of DNA-templated transcription#GO:0045892;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;regulation of DNA-templated transcription#GO:0006355;negative regulation of metabolic process#GO:0009892;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG193366|UniProtKB=T1FUX2 T1FUX2 20212618 PTHR15140:SF6 TUBULIN-SPECIFIC CHAPERONE E TUBULIN-SPECIFIC CHAPERONE COFACTOR E-LIKE PROTEIN chaperone#PC00072 HELRO|EnsemblGenome=HelroG169764|UniProtKB=T1F2B1 T1F2B1 20202961 PTHR23167:SF88 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG108146|UniProtKB=T1EEF9 T1EEF9 20194961 PTHR43807:SF20 FI04487P FI04487P transaminase activity#GO:0008483;transferase activity#GO:0016740;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 transaminase#PC00216;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG194636|UniProtKB=T1FW94 T1FW94 20213090 PTHR10762:SF2 DIPHTHAMIDE BIOSYNTHESIS PROTEIN 2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;primary metabolic process#GO:0044238 HELRO|EnsemblGenome=HelroG166978|UniProtKB=T1EYU4 T1EYU4 20201744 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185850|UniProtKB=T1FND1 T1FND1 20210328 PTHR11599:SF62 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT BETA TYPE-3 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;proteasome complex#GO:0000502;membrane-bounded organelle#GO:0043227;endopeptidase complex#GO:1905369;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protease#PC00190;protein modifying enzyme#PC00260 Parkinson disease#P00049>20S proteasome#P01227 HELRO|EnsemblGenome=HelroG160589|UniProtKB=T1EQG5 T1EQG5 20198815 PTHR15180:SF1 GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1 GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;RNA metabolic process#GO:0016070;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;rRNA transcription#GO:0009303;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;heterocycle metabolic process#GO:0046483;transcription by RNA polymerase III#GO:0006383;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;ncRNA transcription#GO:0098781;aromatic compound biosynthetic process#GO:0019438 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;transcription factor TFIIIC complex#GO:0000127 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG79231|UniProtKB=T1G3L6 T1G3L6 20215664 PTHR45810:SF1 HISTONE H3.2 HISTONE H3-LIKE CENTROMERIC PROTEIN A chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG157121|UniProtKB=T1EM64 T1EM64 20197664 PTHR45629:SF7 SNF2/RAD54 FAMILY MEMBER DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED damaged DNA-binding protein#PC00086;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG178714|UniProtKB=T1FDM0 T1FDM0 20206919 PTHR12814:SF2 RNA-BINDING PROTEIN NOB1 RNA-BINDING PROTEIN NOB1 catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 preribosome, small subunit precursor#GO:0030688;ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG63631|UniProtKB=T1FXI5 T1FXI5 20213533 PTHR11610:SF173 LIPASE LIPASE DOMAIN-CONTAINING PROTEIN-RELATED hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;lipid catabolic process#GO:0016042;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 lipase#PC00143;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG184495|UniProtKB=T1FLB6 T1FLB6 20209615 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG96656|UniProtKB=T1G9D2 T1G9D2 20217679 PTHR12354:SF1 INTERFERON-RELATED DEVELOPMENTAL REGULATOR INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1 HELRO|EnsemblGenome=HelroG66618|UniProtKB=T1FYN1 T1FYN1 20213929 PTHR12247:SF129 POLYCOMB GROUP PROTEIN SOP-2-RELATED PROTEIN 3 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;histone binding#GO:0042393;binding#GO:0005488;chromatin binding#GO:0003682 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG164242|UniProtKB=T1EV56 T1EV56 20200456 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184215|UniProtKB=T1FKS3 T1FKS3 20209422 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186959|UniProtKB=T1FP49 T1FP49 20210596 PTHR11588:SF504 TUBULIN TUBULIN BETA-1 CHAIN-RELATED carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;structural molecule activity#GO:0005198;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;structural constituent of cytoskeleton#GO:0005200 cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;microtubule-based process#GO:0007017;organelle organization#GO:0006996;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;cell cycle#GO:0007049;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 tubulin#PC00228;microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Microtubule#P00780;Huntington disease#P00029>beta-Tubulin#P00790;Cytoskeletal regulation by Rho GTPase#P00016>tubulin#P00526 HELRO|EnsemblGenome=HelroG157479|UniProtKB=T1EMB9 T1EMB9 20197719 PTHR47958:SF32 ATP-DEPENDENT RNA HELICASE DBP3 RNA HELICASE nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG186177|UniProtKB=T1FNR9 T1FNR9 20210466 PTHR13486:SF2 TELOMERE LENGTH AND SILENCING PROTEIN 1 TLS1 FAMILY MEMBER SPLICING FACTOR C9ORF78 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG158735|UniProtKB=T1EN64 T1EN64 20198014 PTHR21215:SF0 LD36024P LD36024P HELRO|EnsemblGenome=HelroG76186|UniProtKB=T1G2G4 T1G2G4 20215262 PTHR22914:SF42 CHITIN SYNTHASE CHITIN SYNTHASE acetylglucosaminyltransferase activity#GO:0008375;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758 carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;aminoglycan biosynthetic process#GO:0006023;amino sugar metabolic process#GO:0006040;aminoglycan metabolic process#GO:0006022;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;cell septum#GO:0030428 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG164142|UniProtKB=T1EUZ8 T1EUZ8 20200398 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172276|UniProtKB=T1F563 T1F563 20203962 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG113279|UniProtKB=T1EFR4 T1EFR4 20195416 PTHR11675:SF101 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 5 transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG174026|UniProtKB=T1F7I0 T1F7I0 20204779 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164127|UniProtKB=T1EUZ1 T1EUZ1 20200391 PTHR10642:SF26 RIBONUCLEASE H1 RIBONUCLEASE H1 catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular nitrogen compound catabolic process#GO:0044270;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic cyclic compound catabolic process#GO:1901361;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;organic substance catabolic process#GO:1901575;nucleobase-containing compound catabolic process#GO:0034655;DNA replication#GO:0006260;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;cellular catabolic process#GO:0044248 endoribonuclease#PC00094;RNA metabolism protein#PC00031 DNA replication#P00017>RNase H#P00538 HELRO|EnsemblGenome=HelroG71468|UniProtKB=T1G0M0 T1G0M0 20214618 PTHR22957:SF502 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;activation of GTPase activity#GO:0090630;biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG73469|UniProtKB=T1G1E1 T1G1E1 20214889 PTHR10966:SF0 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2 protein binding#GO:0005515;transcription factor binding#GO:0008134;binding#GO:0005488;TBP-class protein binding#GO:0017025 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;RNA metabolic process#GO:0016070;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;RNA polymerase II preinitiation complex assembly#GO:0051123;transcription initiation at RNA polymerase II promoter#GO:0006367;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;DNA-directed RNA polymerase complex#GO:0000428;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nucleoplasm#GO:0005654;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;transcription regulator complex#GO:0005667;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 general transcription factor#PC00259 General transcription regulation#P00023>TFIIA complex#P00662;Transcription regulation by bZIP transcription factor#P00055>TFIIA complex#P01390 HELRO|EnsemblGenome=HelroG162666|UniProtKB=T1ESZ6 T1ESZ6 20199696 PTHR10075:SF100 BASIGIN RELATED FASCICLIN-2 cell adhesion molecule binding#GO:0050839;cell-cell adhesion mediator activity#GO:0098632;protein binding#GO:0005515;binding#GO:0005488 neuron projection guidance#GO:0097485;cell recognition#GO:0008037;neurogenesis#GO:0022008;cell projection organization#GO:0030030;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;axonogenesis#GO:0007409;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156;cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cell morphogenesis#GO:0000902;cellular process#GO:0009987;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure development#GO:0048856;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;axon#GO:0030424 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG158730|UniProtKB=T1EN59 T1EN59 20198009 PTHR12400:SF51 INOSITOL POLYPHOSPHATE KINASE INOSITOL POLYPHOSPHATE MULTIKINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 organic hydroxy compound metabolic process#GO:1901615;organophosphate biosynthetic process#GO:0090407;alcohol biosynthetic process#GO:0046165;cellular metabolic process#GO:0044237;alcohol metabolic process#GO:0006066;organic hydroxy compound biosynthetic process#GO:1901617;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;organophosphate metabolic process#GO:0019637;small molecule biosynthetic process#GO:0044283;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 kinase#PC00137 HELRO|EnsemblGenome=HelroG81976|UniProtKB=T1G4L2 T1G4L2 20216010 PTHR10556:SF57 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE 1 oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 lipid metabolic process#GO:0006629;steroid metabolic process#GO:0008202;organic cyclic compound metabolic process#GO:1901360;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;lipid biosynthetic process#GO:0008610;steroid biosynthetic process#GO:0006694;metabolic process#GO:0008152;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG183713|UniProtKB=T1FK35 T1FK35 20209184 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG194356|UniProtKB=T1FVZ2 T1FVZ2 20212988 PTHR45816:SF4 MIR DOMAIN-CONTAINING PROTEIN RYR_IP3R HOMOLOGY ASSOCIATED DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171137|UniProtKB=T1F3U5 T1F3U5 20203494 PTHR24412:SF466 KELCH PROTEIN RING CANAL KELCH PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG159899|UniProtKB=T1EPI8 T1EPI8 20198488 PTHR10656:SF42 CELL FATE DETERMINING PROTEIN MAB21-RELATED CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED transferase#PC00220;nucleotidyltransferase#PC00174;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG171875|UniProtKB=T1F4S8 T1F4S8 20203827 PTHR21437:SF1 WIDE AWAKE WIDE AWAKE HELRO|EnsemblGenome=HelroG116813|UniProtKB=T1EGI1 T1EGI1 20195683 PTHR10545:SF29 DIAMINE N-ACETYLTRANSFERASE GH14572P-RELATED acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;catalytic activity#GO:0003824;N-acyltransferase activity#GO:0016410 acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG187411|UniProtKB=T1FP97 T1FP97 20210644 PTHR11034:SF40 N-MYC DOWNSTREAM REGULATED BCDNA.GH02439 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG181129|UniProtKB=T1FGN2 T1FGN2 20207981 PTHR33244:SF3 INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED PEPTIDASE A2 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG79604|UniProtKB=T1G3Q7 T1G3Q7 20215705 PTHR22894:SF5 RING-TYPE DOMAIN-CONTAINING PROTEIN RING-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165252|UniProtKB=T1EWI1 T1EWI1 20200931 PTHR21522:SF32 PROTON CHANNEL OTOP OTOPETRIN-2 monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078;proton channel activity#GO:0015252;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;proton transmembrane transport#GO:1902600;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG63257|UniProtKB=T1FXD0 T1FXD0 20213478 PTHR15315:SF64 RING FINGER PROTEIN 41, 151 RING FINGER PROTEIN 151 HELRO|EnsemblGenome=HelroG111085|UniProtKB=T1EF79 T1EF79 20195231 PTHR11584:SF394 SERINE/THREONINE PROTEIN KINASE APOPTOTIC SIGNAL-REGULATING KINASE 1, ISOFORM C transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 FGF signaling pathway#P00021>MEKK1-5#P00634;EGF receptor signaling pathway#P00018>MEKK1-5#P00553 HELRO|EnsemblGenome=HelroG193363|UniProtKB=T1FUX0 T1FUX0 20212616 PTHR12794:SF0 GEMIN2 GEM-ASSOCIATED PROTEIN 2 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;spliceosomal snRNP assembly#GO:0000387;organic substance metabolic process#GO:0071704;mRNA splicing, via spliceosome#GO:0000398;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375 SMN-Sm protein complex#GO:0034719;cytoplasm#GO:0005737;SMN complex#GO:0032797;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;Sm-like protein family complex#GO:0120114;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG164588|UniProtKB=T1EVL8 T1EVL8 20200618 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184040|UniProtKB=T1FKH0 T1FKH0 20209319 PTHR15414:SF0 OS-9-RELATED ENDOPLASMIC RETICULUM LECTIN 1 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;protein catabolic process#GO:0030163;nitrogen compound transport#GO:0071705;organonitrogen compound catabolic process#GO:1901565;establishment of protein localization#GO:0045184;organic substance transport#GO:0071702;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;response to organic substance#GO:0010033;macromolecule catabolic process#GO:0009057;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;ERAD pathway#GO:0036503;response to organonitrogen compound#GO:0010243;cellular process#GO:0009987;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;cellular macromolecule localization#GO:0070727;response to chemical#GO:0042221;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular response to stress#GO:0033554 membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;endoplasmic reticulum lumen#GO:0005788;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG131165|UniProtKB=T1EHV4 T1EHV4 20196154 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG192795|UniProtKB=T1FUB0 T1FUB0 20212406 PTHR10155:SF32 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT LP02169P enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;phosphatidylinositol 3-kinase complex#GO:0005942;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;membrane#GO:0016020;transferase complex, transferring phosphorus-containing groups#GO:0061695;extrinsic component of membrane#GO:0019898 kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG113693|UniProtKB=T1EFV1 T1EFV1 20195453 PTHR24208:SF166 LIM/HOMEOBOX PROTEIN LHX LIM HOMEOBOX TRANSCRIPTION FACTOR 1 ALPHA, ISOFORM B sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG70316|UniProtKB=T1G045 T1G045 20214443 PTHR13976:SF76 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED AT27789P ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG172540|UniProtKB=T1F5H4 T1F5H4 20204073 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG173528|UniProtKB=T1F6Y1 T1F6Y1 20204580 PTHR43010:SF1 UNIVERSAL STRESS PROTEIN SLR1230 USPA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG83641|UniProtKB=T1G585 T1G585 20216232 PTHR31849:SF1 CYSTEINE-RICH PDF MOTIF DOMAIN-CONTAINING PROTEIN 1 CYSTEINE-RICH DPF MOTIF DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG96485|UniProtKB=T1G9C4 T1G9C4 20217671 PTHR14167:SF92 SH3 DOMAIN-CONTAINING CIN85 AND CD2AP RELATED, ISOFORM J cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cell motility#GO:0048870;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;cell migration#GO:0016477 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG183684|UniProtKB=T1FK11 T1FK11 20209160 PTHR46927:SF3 AGAP005574-PA THAP-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171438|UniProtKB=T1F4A1 T1F4A1 20203650 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG193474|UniProtKB=T1FV14 T1FV14 20212660 PTHR13946:SF28 DNA-DIRECTED RNA POLYMERASE I,II,III DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;RNA polymerase activity#GO:0097747;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 General transcription by RNA polymerase I#P00022>RNA Polymerase I Complex#P00652 HELRO|EnsemblGenome=HelroG158271|UniProtKB=T1EML4 T1EML4 20197814 PTHR23428:SF349 HISTONE H2B HISTONE H2B chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG63798|UniProtKB=T1FXK4 T1FXK4 20213552 PTHR24193:SF121 ANKYRIN REPEAT PROTEIN ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D HELRO|EnsemblGenome=HelroG170361|UniProtKB=T1F2Z0 T1F2Z0 20203189 PTHR34253:SF1 PROTEIN LLP HOMOLOG PROTEIN LLP HOMOLOG nucleic acid binding#GO:0003676;basal RNA polymerase II transcription machinery binding#GO:0001099;RNA binding#GO:0003723;protein binding#GO:0005515;basal transcription machinery binding#GO:0001098;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular developmental process#GO:0048869;developmental cell growth#GO:0048588;neuron projection extension#GO:1990138;neurogenesis#GO:0022008;developmental growth involved in morphogenesis#GO:0060560;developmental growth#GO:0048589;cell projection organization#GO:0030030;developmental process#GO:0032502;multicellular organism development#GO:0007275;growth#GO:0040007;cell morphogenesis#GO:0000902;cell projection morphogenesis#GO:0048858;cellular component organization#GO:0016043;cell growth#GO:0016049;nervous system development#GO:0007399;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;cell differentiation#GO:0030154;system development#GO:0048731;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;neuron projection morphogenesis#GO:0048812;neuron development#GO:0048666;generation of neurons#GO:0048699;plasma membrane bounded cell projection morphogenesis#GO:0120039 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG167054|UniProtKB=T1EYY4 T1EYY4 20201784 PTHR10925:SF5 N-ACETYLTRANSFERASE 10 RNA CYTIDINE ACETYLTRANSFERASE tRNA binding#GO:0000049;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;acetyltransferase activity#GO:0016407;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;N-acyltransferase activity#GO:0016410 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA modification#GO:0009451;rRNA modification#GO:0000154;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;ribosome biogenesis#GO:0042254;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG67628|UniProtKB=T1FZ31 T1FZ31 20214079 PTHR11909:SF155 CASEIN KINASE-RELATED GILGAMESH, ISOFORM L transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 signal transduction#GO:0007165;macromolecule modification#GO:0043412;transport#GO:0006810;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;endocytosis#GO:0006897;cellular metabolic process#GO:0044237;vesicle-mediated transport#GO:0016192;organonitrogen compound metabolic process#GO:1901564;protein phosphorylation#GO:0006468;cell communication#GO:0007154;cellular process#GO:0009987;primary metabolic process#GO:0044238;localization#GO:0051179;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;import into cell#GO:0098657 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Parkinson disease#P00049>Casein kinase I#P01242 HELRO|EnsemblGenome=HelroG178071|UniProtKB=T1FCP4 T1FCP4 20206593 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG170574|UniProtKB=T1F371 T1F371 20203270 PTHR14948:SF25 NG5 DUF4190 DOMAIN-CONTAINING PROTEIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG73452|UniProtKB=T1G1E0 T1G1E0 20214888 PTHR21255:SF4 T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN DYNEIN LIGHT CHAIN TCTEX-TYPE protein binding#GO:0005515;binding#GO:0005488 microtubule-based movement#GO:0007018;cellular process#GO:0009987;microtubule-based process#GO:0007017 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;microtubule cytoskeleton#GO:0015630;dynein complex#GO:0030286;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic dynein complex#GO:0005868;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG169501|UniProtKB=T1F207 T1F207 20202857 PTHR21500:SF0 TUBULIN-SPECIFIC CHAPERONE A TUBULIN-SPECIFIC CHAPERONE A cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein-containing complex assembly#GO:0065003;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;protein folding#GO:0006457;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperonin#PC00073 HELRO|EnsemblGenome=HelroG179990|UniProtKB=T1FFB3 T1FFB3 20207512 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG166608|UniProtKB=T1EYA5 T1EYA5 20201555 PTHR10166:SF66 VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED VWFA AND CACHE DOMAIN-CONTAINING PROTEIN CG16868 calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated calcium channel activity#GO:0005245;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 voltage-gated calcium channel complex#GO:0005891;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;calcium channel complex#GO:0034704;membrane#GO:0016020;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG190941|UniProtKB=T1FSG0 T1FSG0 20211757 PTHR10306:SF17 SYNAPTOPHYSIN MARVEL DOMAIN-CONTAINING PROTEIN membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG78764|UniProtKB=T1G3F4 T1G3F4 20215602 PTHR24351:SF201 RIBOSOMAL PROTEIN S6 KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG165783|UniProtKB=T1EXA1 T1EXA1 20201201 PTHR11202:SF36 SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER ACTIN NUCLEATION-PROMOTING FACTOR WASL scaffold/adaptor protein#PC00226 Huntington disease#P00029>N-Wasp#P00769;Cytoskeletal regulation by Rho GTPase#P00016>N-WASP#P00525 HELRO|EnsemblGenome=HelroG171806|UniProtKB=T1F4P7 T1F4P7 20203796 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG89896|UniProtKB=T1G7I9 T1G7I9 20217036 PTHR20855:SF52 ADIPOR/PROGESTIN RECEPTOR-RELATED ADIPONECTIN RECEPTOR PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG76918|UniProtKB=T1G2R3 T1G2R3 20215361 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185129|UniProtKB=T1FMF6 T1FMF6 20210005 PTHR23055:SF178 CALCIUM BINDING PROTEINS NEUROCALCIN HOMOLOG cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG190823|UniProtKB=T1FSB7 T1FSB7 20211714 PTHR23159:SF52 CENTROSOMAL PROTEIN 2 SUBFAMILY NOT NAMED chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG87093|UniProtKB=T1G6L5 T1G6L5 20216712 PTHR22957:SF333 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 25 nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;activation of GTPase activity#GO:0090630;biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG150188|UniProtKB=T1EKE7 T1EKE7 20197047 PTHR24208:SF168 LIM/HOMEOBOX PROTEIN LHX PROTEIN APTEROUS sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;neurogenesis#GO:0022008;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;system development#GO:0048731;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;regulation of macromolecule biosynthetic process#GO:0010556;generation of neurons#GO:0048699;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG74949|UniProtKB=T1G1Y2 T1G1Y2 20215080 PTHR47961:SF12 DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED HELICASE POLQ-LIKE DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG182117|UniProtKB=T1FHS2 T1FHS2 20208371 PTHR36191:SF1 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168741|UniProtKB=T1F0W8 T1F0W8 20202468 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cell communication#GO:0007154;cellular process#GO:0009987;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;Notch signaling pathway#GO:0007219 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG176655|UniProtKB=T1FAR7 T1FAR7 20205916 PTHR13865:SF28 TIGHT JUNCTION PROTEIN POLYCHAETOID, ISOFORM O cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;binding#GO:0005488 localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;cell-cell junction organization#GO:0045216;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;protein localization to cell junction#GO:1902414;cell junction organization#GO:0034330;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cellular process#GO:0009987;protein localization#GO:0008104 tight junction#GO:0070160;cell-cell junction#GO:0005911;anchoring junction#GO:0070161;cell junction#GO:0030054;bicellular tight junction#GO:0005923;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;apical junction complex#GO:0043296;plasma membrane#GO:0005886 tight junction#PC00214 HELRO|EnsemblGenome=HelroG100946|UniProtKB=T1ED23 T1ED23 20194475 PTHR11777:SF9 ALANYL-TRNA SYNTHETASE ALANINE--TRNA LIGASE, CYTOPLASMIC catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG170488|UniProtKB=T1F343 T1F343 20203242 PTHR13140:SF550 MYOSIN MYOSIN-IIIB ISOFORM X1 microfilament motor activity#GO:0000146;cytoskeletal protein binding#GO:0008092;ATP-dependent activity#GO:0140657;binding#GO:0005488;actin filament binding#GO:0051015;cytoskeletal motor activity#GO:0003774;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG69265|UniProtKB=T1FZS2 T1FZS2 20214320 PTHR23122:SF7 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK PERIPHERAL PLASMA MEMBRANE PROTEIN CASK protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 regulation of cell communication#GO:0010646;cellular localization#GO:0051641;macromolecule localization#GO:0033036;regulation of signaling#GO:0023051;regulation of localization#GO:0032879;regulation of secretion by cell#GO:1903530;cellular process#GO:0009987;regulation of neurotransmitter secretion#GO:0046928;protein localization#GO:0008104;regulation of biological process#GO:0050789;localization#GO:0051179;regulation of transport#GO:0051049;cellular macromolecule localization#GO:0070727;regulation of cellular process#GO:0050794;regulation of secretion#GO:0051046;modulation of chemical synaptic transmission#GO:0050804;biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177 cell junction#GO:0030054;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911;anchoring junction#GO:0070161;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 Parkinson disease#P00049>CASK#P01232;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CaMK#P00847 HELRO|EnsemblGenome=HelroG69024|UniProtKB=T1FZN6 T1FZN6 20214284 PTHR16089:SF28 REST COREPRESSOR COREST PROTEIN-RELATED REST COREPRESSOR molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;protein-macromolecule adaptor activity#GO:0030674 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;histone deacetylase complex#GO:0000118;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG76967|UniProtKB=T1G2R9 T1G2R9 20215367 PTHR11051:SF8 GLYCOSYL HYDROLASE-RELATED PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 carbohydrate metabolic process#GO:0005975;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238;metabolic process#GO:0008152 glycosidase#PC00110;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG158882|UniProtKB=T1END2 T1END2 20198082 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166445|UniProtKB=T1EY53 T1EY53 20201503 PTHR47537:SF2 CUBILIN CUBILIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG180495|UniProtKB=T1FFZ5 T1FFZ5 20207744 PTHR46518:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 151 OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 3 cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;outer dynein arm assembly#GO:0036158;cell projection organization#GO:0030030;microtubule cytoskeleton organization#GO:0000226;microtubule-based movement#GO:0007018;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;axoneme assembly#GO:0035082;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;cilium movement#GO:0003341;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection assembly#GO:0120031 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;cilium#GO:0005929;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG162326|UniProtKB=T1ESI3 T1ESI3 20199533 PTHR10258:SF8 CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA CALCIUM-ACTIVATED POTASSIUM CHANNEL BK ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;molecular function regulator activity#GO:0098772;transporter regulator activity#GO:0141108;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic ion-gated channel activity#GO:0022839;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium-activated cation channel activity#GO:0005227;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;potassium channel regulator activity#GO:0015459;ligand-gated monoatomic cation channel activity#GO:0099094;channel regulator activity#GO:0016247;monoatomic ion channel activity#GO:0005216;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 detection of stimulus#GO:0051606;response to stimulus#GO:0050896;response to chemical#GO:0042221;detection of chemical stimulus#GO:0009593 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG157956|UniProtKB=T1EMI1 T1EMI1 20197781 PTHR12411:SF992 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN F cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197 macromolecule catabolic process#GO:0009057;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;proteolysis#GO:0006508;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;catabolic process#GO:0009056;organonitrogen compound catabolic process#GO:1901565;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;lysosome#GO:0005764;intracellular membrane-bounded organelle#GO:0043231;extracellular region#GO:0005576;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;organelle#GO:0043226;lytic vacuole#GO:0000323;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG193623|UniProtKB=T1FV70 T1FV70 20212716 PTHR12953:SF0 MEMBRANE PROTEIN CH1 RELATED SUN DOMAIN-CONTAINING OSSIFICATION FACTOR macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 structural protein#PC00211 HELRO|EnsemblGenome=HelroG77785|UniProtKB=T1G339 T1G339 20215487 PTHR10582:SF2 TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN INACTIVE passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;channel activity#GO:0015267;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;calcium ion transport#GO:0006816;calcium ion import#GO:0070509;localization#GO:0051179;import across plasma membrane#GO:0098739;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;calcium ion transmembrane import into cytosol#GO:0097553;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;import into cell#GO:0098657;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG101552|UniProtKB=T1ED54 T1ED54 20194506 PTHR45672:SF3 PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED THIOREDOXIN DOMAIN-CONTAINING PROTEIN 5 isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;protein disulfide isomerase activity#GO:0003756 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG191910|UniProtKB=T1FTE7 T1FTE7 20212094 PTHR33562:SF18 ATILLA, ISOFORM B-RELATED-RELATED BOUDIN-RELATED HELRO|EnsemblGenome=HelroG188105|UniProtKB=T1FPN1 T1FPN1 20210778 PTHR22765:SF450 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE HRD1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG96238|UniProtKB=T1G9A9 T1G9A9 20217656 PTHR10218:SF360 GTP-BINDING PROTEIN ALPHA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;ribonucleoside triphosphate phosphatase activity#GO:0017111;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 regulation of biological process#GO:0050789;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;side of membrane#GO:0098552;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;extrinsic component of membrane#GO:0019898 heterotrimeric G-protein#PC00117;G-protein#PC00020 HELRO|EnsemblGenome=HelroG179329|UniProtKB=T1FEK2 T1FEK2 20207251 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG186759|UniProtKB=T1FP30 T1FP30 20210577 PTHR15092:SF37 POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1 TARGET OF EGR1 PROTEIN 1 hydrolase activity, acting on ester bonds#GO:0016788;nucleic acid binding#GO:0003676;nuclease activity#GO:0004518;binding#GO:0005488;catalytic activity#GO:0003824;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;catalytic activity, acting on a nucleic acid#GO:0140640;3'-5'-RNA exonuclease activity#GO:0000175;snRNA binding#GO:0017069;exonuclease activity#GO:0004527;catalytic activity, acting on RNA#GO:0140098;RNA binding#GO:0003723;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;3'-5' exonuclease activity#GO:0008408;RNA nuclease activity#GO:0004540 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;snRNA metabolic process#GO:0016073;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;snRNA 3'-end processing#GO:0034472;snRNA processing#GO:0016180;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear body#GO:0016604;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG64352|UniProtKB=T1FXT3 T1FXT3 20213631 PTHR24056:SF400 CELL DIVISION PROTEIN KINASE KINASE, PUTATIVE-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG66185|UniProtKB=T1FYI2 T1FYI2 20213880 PTHR10721:SF1 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44 protein binding#GO:0005515;protein-folding chaperone binding#GO:0051087;binding#GO:0005488 cellular localization#GO:0051641;transmembrane transport#GO:0055085;macromolecule localization#GO:0033036;transport#GO:0006810;protein transmembrane transport#GO:0071806;protein targeting#GO:0006605;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;protein localization to mitochondrion#GO:0070585;cellular process#GO:0009987;protein transmembrane import into intracellular organelle#GO:0044743;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;mitochondrial transport#GO:0006839;organic substance transport#GO:0071702;protein import into mitochondrial matrix#GO:0030150;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein targeting to mitochondrion#GO:0006626;establishment of protein localization to mitochondrion#GO:0072655;protein transport#GO:0015031;protein localization to organelle#GO:0033365;mitochondrial transmembrane transport#GO:1990542 envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;organelle inner membrane#GO:0019866;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227 transporter#PC00227 HELRO|EnsemblGenome=HelroG173987|UniProtKB=T1F7G3 T1F7G3 20204762 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG85424|UniProtKB=T1G5W8 T1G5W8 20216465 PTHR24270:SF8 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED LD11117P-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 apolipoprotein#PC00052 HELRO|EnsemblGenome=HelroG63747|UniProtKB=T1FXJ7 T1FXJ7 20213545 PTHR15454:SF56 NISCHARIN RELATED PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7-RELATED cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG170769|UniProtKB=T1F3E5 T1F3E5 20203344 PTHR10170:SF10 HUNTINGTON DISEASE PROTEIN HUNTINGTIN cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 Huntington disease#P00029>Htt#P00766;Huntington disease#P00029>PolyQ Htt#P00800;Huntington disease#P00029>PolyQ HTT#G01532;Huntington disease#P00029>Truncated Htt#P00761;Huntington disease#P00029>HTT#G01530 HELRO|EnsemblGenome=HelroG101329|UniProtKB=T1ED40 T1ED40 20194493 PTHR11203:SF11 CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3 hydrolase activity, acting on ester bonds#GO:0016788;nucleic acid binding#GO:0003676;nuclease activity#GO:0004518;5'-3' exonuclease activity#GO:0008409;binding#GO:0005488;catalytic activity#GO:0003824;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;endonuclease activity#GO:0004519;catalytic activity, acting on a nucleic acid#GO:0140640;exonuclease activity#GO:0004527;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;RNA binding#GO:0003723;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;RNA nuclease activity#GO:0004540 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;mRNA polyadenylation#GO:0006378;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;mRNA 3'-end processing#GO:0031124;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mRNA processing#GO:0006397;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;mRNA cleavage factor complex#GO:0005849;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG188141|UniProtKB=T1FPP5 T1FPP5 20210792 PTHR15537:SF2 F-BOX ONLY PROTEIN 7 F-BOX ONLY PROTEIN 7 HELRO|EnsemblGenome=HelroG72885|UniProtKB=T1G167 T1G167 20214815 PTHR48024:SF56 GEO13361P1-RELATED HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A0 HELRO|EnsemblGenome=HelroG74054|UniProtKB=T1G1L8 T1G1L8 20214966 PTHR23055:SF172 CALCIUM BINDING PROTEINS EF-HAND DOMAIN-CONTAINING PROTEIN cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG186672|UniProtKB=T1FP22 T1FP22 20210569 PTHR18945:SF865 NEUROTRANSMITTER GATED ION CHANNEL NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA7, ISOFORM E ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG69899|UniProtKB=T1FZZ4 T1FZZ4 20214392 PTHR13803:SF39 SEC24-RELATED PROTEIN SECRETORY 24AB, ISOFORM A cation binding#GO:0043169;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;binding#GO:0005488;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;protein binding#GO:0005515;ion binding#GO:0043167;SNARE binding#GO:0000149 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;membrane organization#GO:0061024;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;vesicle budding from membrane#GO:0006900;organelle organization#GO:0006996;COPII-coated vesicle budding#GO:0090114;establishment of localization in cell#GO:0051649;vesicle organization#GO:0016050;intracellular transport#GO:0046907 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;ER to Golgi transport vesicle membrane#GO:0012507;endoplasmic reticulum exit site#GO:0070971;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;vesicle coat#GO:0030120;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;transport vesicle membrane#GO:0030658;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane coat#GO:0030117;coated vesicle membrane#GO:0030662;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;coated membrane#GO:0048475;cytoplasmic vesicle membrane#GO:0030659;endoplasmic reticulum#GO:0005783 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG113932|UniProtKB=T1EFX5 T1EFX5 20195477 PTHR43327:SF10 STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL transporter#PC00227 HELRO|EnsemblGenome=HelroG189969|UniProtKB=T1FRJ6 T1FRJ6 20211443 PTHR10279:SF10 ORNITHINE DECARBOXYLASE ANTIZYME ORNITHINE DECARBOXYLASE ANTIZYME enzyme inhibitor activity#GO:0004857;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of protein metabolic process#GO:0051246;regulation of catabolic process#GO:0009894;regulation of nitrogen compound metabolic process#GO:0051171;regulation of protein catabolic process#GO:0042176;positive regulation of macromolecule metabolic process#GO:0010604;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;positive regulation of protein metabolic process#GO:0051247;positive regulation of metabolic process#GO:0009893;regulation of macromolecule metabolic process#GO:0060255;positive regulation of catabolic process#GO:0009896;biological regulation#GO:0065007;positive regulation of protein catabolic process#GO:0045732;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG64698|UniProtKB=T1FXY1 T1FXY1 20213679 PTHR23048:SF33 MYOSIN LIGHT CHAIN 1, 3 MYOSIN LIGHT CHAIN ALKALI supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;supramolecular fiber#GO:0099512;supramolecular polymer#GO:0099081;myosin complex#GO:0016459;contractile fiber#GO:0043292;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG133959|UniProtKB=T1EI29 T1EI29 20196229 PTHR11040:SF140 ZINC/IRON TRANSPORTER ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;transition metal ion transport#GO:0000041;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG77520|UniProtKB=T1G2Z2 T1G2Z2 20215440 PTHR21213:SF0 GEO09665P1-RELATED ZINC FINGER PROTEIN 706 HELRO|EnsemblGenome=HelroG89630|UniProtKB=T1G7F3 T1G7F3 20217000 PTHR28153:SF1 PROTEIN, PUTATIVE-RELATED DUF4484 DOMAIN-CONTAINING PROTEIN intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;lipid droplet#GO:0005811;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG166196|UniProtKB=T1EXW1 T1EXW1 20201411 PTHR14196:SF0 ODD-SKIPPED - RELATED PROTEIN BOWEL sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;embryo development#GO:0009790;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG165012|UniProtKB=T1EW47 T1EW47 20200797 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG104567|UniProtKB=T1EDM4 T1EDM4 20194676 PTHR12962:SF1 CALCIUM-REGULATED HEAT STABLE PROTEIN CRHSP-24-RELATED COLD SHOCK DOMAIN-CONTAINING PROTEIN CG9705 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159;mRNA 3'-UTR binding#GO:0003730 regulation of mRNA stability#GO:0043488;regulation of catabolic process#GO:0009894;regulation of mRNA catabolic process#GO:0061013;regulation of nitrogen compound metabolic process#GO:0051171;regulation of cellular catabolic process#GO:0031329;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of biological quality#GO:0065008;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG195105|UniProtKB=T1FWR4 T1FWR4 20213259 PTHR24171:SF9 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HELRO|EnsemblGenome=HelroG135540|UniProtKB=T1EI94 T1EI94 20196294 PTHR48112:SF32 HIGH MOBILITY GROUP PROTEIN DSP1 HIGH MOBILITY GROUP PROTEIN B3 HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG67423|UniProtKB=T1FZ07 T1FZ07 20214055 PTHR46479:SF1 BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2 BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2 HELRO|EnsemblGenome=HelroG164478|UniProtKB=T1EVH3 T1EVH3 20200573 PTHR34093:SF1 CHLORIDE CHANNEL CLIC-LIKE PROTEIN 1 CHLORIDE CHANNEL CLIC-LIKE PROTEIN 1 inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG82635|UniProtKB=T1G4U4 T1G4U4 20216092 PTHR12603:SF0 CCR4-NOT TRANSCRIPTION COMPLEX RELATED CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 CCR4-NOT complex#GO:0030014;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG193817|UniProtKB=T1FVE1 T1FVE1 20212787 PTHR45761:SF1 EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG189103|UniProtKB=T1FQN5 T1FQN5 20211132 PTHR24118:SF100 POTE ANKYRIN DOMAIN FYVE-TYPE DOMAIN-CONTAINING PROTEIN membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG161662|UniProtKB=T1ERR5 T1ERR5 20199265 PTHR16231:SF2 COMM DOMAIN-CONTAINING PROTEIN 4-8 FAMILY MEMBER COMM DOMAIN-CONTAINING PROTEIN 7 NF-kappaB binding#GO:0051059;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515;transcription factor binding#GO:0008134;binding#GO:0005488;DNA-binding transcription factor binding#GO:0140297 negative regulation of cellular metabolic process#GO:0031324;signal transduction#GO:0007165;negative regulation of biological process#GO:0048519;response to cytokine#GO:0034097;negative regulation of RNA metabolic process#GO:0051253;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;regulation of RNA biosynthetic process#GO:2001141;negative regulation of NF-kappaB transcription factor activity#GO:0032088;regulation of biological process#GO:0050789;regulation of molecular function#GO:0065009;regulation of biosynthetic process#GO:0009889;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;cytokine-mediated signaling pathway#GO:0019221;negative regulation of DNA-templated transcription#GO:0045892;signaling#GO:0023052;negative regulation of cellular process#GO:0048523;response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;regulation of DNA-binding transcription factor activity#GO:0051090;negative regulation of biosynthetic process#GO:0009890;cellular response to chemical stimulus#GO:0070887;cellular response to organic substance#GO:0071310;regulation of DNA-templated transcription#GO:0006355;tumor necrosis factor-mediated signaling pathway#GO:0033209;negative regulation of metabolic process#GO:0009892;cell communication#GO:0007154;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;negative regulation of macromolecule biosynthetic process#GO:0010558;response to tumor necrosis factor#GO:0034612;regulation of cellular biosynthetic process#GO:0031326;response to chemical#GO:0042221;cellular response to cytokine stimulus#GO:0071345;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;cellular response to tumor necrosis factor#GO:0071356;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;negative regulation of molecular function#GO:0044092;regulation of cellular metabolic process#GO:0031323;negative regulation of DNA-binding transcription factor activity#GO:0043433 HELRO|EnsemblGenome=HelroG160204|UniProtKB=T1EPY9 T1EPY9 20198639 PTHR21219:SF3 FI19613P1 FI19613P1 HELRO|EnsemblGenome=HelroG191301|UniProtKB=T1FSV1 T1FSV1 20211898 PTHR45931:SF3 SI:CH211-59O9.10 RING ZINC FINGER-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG178124|UniProtKB=T1FCS4 T1FCS4 20206623 PTHR33273:SF4 DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG82872|UniProtKB=T1G4X7 T1G4X7 20216125 PTHR31409:SF0 WASH COMPLEX SUBUNIT 4 WASH COMPLEX SUBUNIT 4 localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;endosome organization#GO:0007032;endosomal transport#GO:0016197;cellular localization#GO:0051641;establishment of localization#GO:0051234;organelle organization#GO:0006996;transport#GO:0006810;endomembrane system organization#GO:0010256;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;vesicle organization#GO:0016050;intracellular transport#GO:0046907;cellular component organization#GO:0016043;cellular process#GO:0009987 cytoplasm#GO:0005737;endosome#GO:0005768;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185064|UniProtKB=T1FMC6 T1FMC6 20209975 PTHR23222:SF1 PROHIBITIN PROHIBITIN-2 cellular component organization or biogenesis#GO:0071840;mitochondrion organization#GO:0007005;cellular component organization#GO:0016043;cellular process#GO:0009987;organelle organization#GO:0006996 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG98115|UniProtKB=T1G9K8 T1G9K8 20217754 PTHR21141:SF5 60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER LARGE RIBOSOMAL SUBUNIT PROTEIN P2 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG164640|UniProtKB=T1EVN7 T1EVN7 20200637 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG80016|UniProtKB=T1G3W5 T1G3W5 20215763 PTHR24637:SF388 COLLAGEN NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG106153|UniProtKB=T1EE04 T1EE04 20194806 PTHR47096:SF1 MISSHAPEN LIKE KINASE 1 MISSHAPEN LIKE KINASE 1 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG75913|UniProtKB=T1G2C6 T1G2C6 20215224 PTHR12612:SF0 NUCLEAR TRANSPORT FACTOR 2 NUCLEAR TRANSPORT FACTOR 2 localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;transport#GO:0006810;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular process#GO:0009987;nuclear transport#GO:0051169 envelope#GO:0031975;nuclear pore#GO:0005643;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG91140|UniProtKB=T1G801 T1G801 20217198 PTHR23418:SF0 ACIREDUCTONE DIOXYGENASE ACIREDUCTONE DIOXYGENASE oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213 oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;sulfur compound metabolic process#GO:0006790;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;alpha-amino acid metabolic process#GO:1901605;aspartate family amino acid metabolic process#GO:0009066;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152 oxygenase#PC00177;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG174466|UniProtKB=T1F854 T1F854 20205003 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180917|UniProtKB=T1FGE9 T1FGE9 20207898 PTHR45749:SF21 FAMILY NOT NAMED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165623|UniProtKB=T1EX33 T1EX33 20201133 PTHR37001:SF5 PHOSPHORYN, PUTATIVE-RELATED-RELATED RIIA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG85168|UniProtKB=T1G5T7 T1G5T7 20216434 PTHR31398:SF0 MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG cellular aromatic compound metabolic process#GO:0006725;nuclear division#GO:0000280;cell cycle process#GO:0022402;nucleobase-containing compound metabolic process#GO:0006139;reciprocal homologous recombination#GO:0140527;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;meiotic cell cycle process#GO:1903046;meiosis I cell cycle process#GO:0061982;reciprocal meiotic recombination#GO:0007131;reproductive process#GO:0022414;meiosis I#GO:0007127;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule metabolic process#GO:0043170;meiotic cell cycle#GO:0051321;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;reproduction#GO:0000003;organelle organization#GO:0006996;meiotic nuclear division#GO:0140013;sexual reproduction#GO:0019953;organelle fission#GO:0048285;cell cycle#GO:0007049;homologous recombination#GO:0035825;DNA metabolic process#GO:0006259 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG95975|UniProtKB=T1G994 T1G994 20217641 PTHR13038:SF10 APG9 AUTOPHAGY 9 AUTOPHAGY-RELATED PROTEIN 9 cellular component assembly#GO:0022607;microautophagy#GO:0016237;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;macroautophagy#GO:0016236;macromolecule localization#GO:0033036;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;autophagy of mitochondrion#GO:0000422;cellular process#GO:0009987;organelle disassembly#GO:1903008;protein localization#GO:0008104;localization#GO:0051179;organelle assembly#GO:0070925;process utilizing autophagic mechanism#GO:0061919;cellular component organization or biogenesis#GO:0071840;reticulophagy#GO:0061709;vacuole organization#GO:0007033;cellular component disassembly#GO:0022411;cellular macromolecule localization#GO:0070727;organelle organization#GO:0006996;autophagosome assembly#GO:0000045;catabolic process#GO:0009056;mitochondrion organization#GO:0007005;autophagy#GO:0006914;piecemeal microautophagy of the nucleus#GO:0034727;metabolic process#GO:0008152;cellular catabolic process#GO:0044248 cytoplasm#GO:0005737;phagophore assembly site#GO:0000407;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;autophagosome#GO:0005776;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG81128|UniProtKB=T1G497 T1G497 20215895 PTHR24291:SF48 CYTOCHROME P450 FAMILY 4 CYTOCHROME P450 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG194626|UniProtKB=T1FW89 T1FW89 20213085 PTHR12271:SF40 POLY A POLYMERASE CID PAP -RELATED POLY(A) RNA POLYMERASE GLD2 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 nucleotidyltransferase#PC00174 HELRO|EnsemblGenome=HelroG162287|UniProtKB=T1ESG4 T1ESG4 20199514 PTHR10480:SF12 PROTEIN UNC-13 HOMOLOG UNC-13, ISOFORM E syntaxin binding#GO:0019905;protein binding#GO:0005515;calmodulin binding#GO:0005516;binding#GO:0005488;SNARE binding#GO:0000149 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG182739|UniProtKB=T1FIN7 T1FIN7 20208686 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG179232|UniProtKB=T1FEE4 T1FEE4 20207193 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG66077|UniProtKB=T1FYG7 T1FYG7 20213865 PTHR21275:SF1 RWD DOMAIN-CONTAINING PROTEIN 4 RWD DOMAIN-CONTAINING PROTEIN 4 HELRO|EnsemblGenome=HelroG161303|UniProtKB=T1ERB5 T1ERB5 20199115 PTHR15657:SF1 THYROID TRANSCRIPTION FACTOR 1-ASSOCIATED PROTEIN 26 THYROID TRANSCRIPTION FACTOR 1-ASSOCIATED PROTEIN 26 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG186739|UniProtKB=T1FP28 T1FP28 20210575 PTHR10480:SF12 PROTEIN UNC-13 HOMOLOG UNC-13, ISOFORM E syntaxin binding#GO:0019905;protein binding#GO:0005515;calmodulin binding#GO:0005516;binding#GO:0005488;SNARE binding#GO:0000149 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG185784|UniProtKB=T1FNA3 T1FNA3 20210300 PTHR11489:SF9 40S RIBOSOMAL PROTEIN SA SMALL RIBOSOMAL SUBUNIT PROTEIN US2 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 cellular component biogenesis#GO:0044085;peptide metabolic process#GO:0006518;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;translation#GO:0006412;protein-RNA complex assembly#GO:0022618;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;ribosome biogenesis#GO:0042254;non-membrane-bounded organelle assembly#GO:0140694;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;peptide biosynthetic process#GO:0043043;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;ribonucleoprotein complex biogenesis#GO:0022613;protein-RNA complex organization#GO:0071826;ribosomal small subunit biogenesis#GO:0042274 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;cytosol#GO:0005829;small ribosomal subunit#GO:0015935;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG170896|UniProtKB=T1F3K5 T1F3K5 20203404 PTHR11893:SF36 INNEXIN INNEXIN-5 cell junction protein#PC00070;gap junction#PC00105 HELRO|EnsemblGenome=HelroG191750|UniProtKB=T1FT96 T1FT96 20212043 PTHR42264:SF3 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN F-BOX DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG81101|UniProtKB=T1G491 T1G491 20215889 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177595|UniProtKB=T1FBX1 T1FBX1 20206320 PTHR36191:SF1 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG95088|UniProtKB=T1G944 T1G944 20217591 PTHR43880:SF12 ALCOHOL DEHYDROGENASE ALCOHOL DEHYDROGENASE CLASS-3 cation binding#GO:0043169;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;ion binding#GO:0043167;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;cellular metabolic process#GO:0044237;cellular process#GO:0009987;response to stimulus#GO:0050896;detoxification#GO:0098754;cellular response to oxygen-containing compound#GO:1901701;small molecule catabolic process#GO:0044282;response to chemical#GO:0042221;catabolic process#GO:0009056;response to toxic substance#GO:0009636;organic substance catabolic process#GO:1901575;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG158528|UniProtKB=T1EMX1 T1EMX1 20197921 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG104748|UniProtKB=T1EDN5 T1EDN5 20194687 PTHR45618:SF9 MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED MITOCHONDRIAL 2-OXOGLUTARATE_MALATE CARRIER PROTEIN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG131512|UniProtKB=T1EHV9 T1EHV9 20196159 PTHR12837:SF15 POLY ADP-RIBOSE GLYCOHYDROLASE POLY(ADP-RIBOSE) GLYCOHYDROLASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 ribonucleoside triphosphate metabolic process#GO:0009199;cellular aromatic compound metabolic process#GO:0006725;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative metabolic process#GO:1901135;regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA metabolic process#GO:0051052;regulation of DNA repair#GO:0006282;nucleotide-sugar metabolic process#GO:0009225;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;regulation of cellular response to stress#GO:0080135;organic cyclic compound metabolic process#GO:1901360;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule metabolic process#GO:0043170;purine ribonucleoside triphosphate metabolic process#GO:0009205;regulation of response to stress#GO:0080134;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;regulation of response to stimulus#GO:0048583;regulation of primary metabolic process#GO:0080090;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;purine nucleoside triphosphate metabolic process#GO:0009144;nucleotide metabolic process#GO:0009117;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosidase#PC00110;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG76461|UniProtKB=T1G2K1 T1G2K1 20215299 PTHR16092:SF14 SEC3/SYNTAXIN-RELATED EXOCYST COMPLEX COMPONENT 1 ISOFORM X1 phosphatidylinositol bisphosphate binding#GO:1902936;small molecule binding#GO:0036094;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;binding#GO:0005488;lipid binding#GO:0008289;phosphatidylinositol binding#GO:0035091;anion binding#GO:0043168;ion binding#GO:0043167;phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981 localization#GO:0051179;localization within membrane#GO:0051668;cellular localization#GO:0051641;vesicle-mediated transport to the plasma membrane#GO:0098876;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;post-Golgi vesicle-mediated transport#GO:0006892;transport#GO:0006810;vesicle-mediated transport#GO:0016192;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;export from cell#GO:0140352;Golgi to plasma membrane transport#GO:0006893;secretion by cell#GO:0032940 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;vesicle tethering complex#GO:0099023;exocyst#GO:0000145;cell cortex#GO:0005938;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034 HELRO|EnsemblGenome=HelroG179172|UniProtKB=T1FEA8 T1FEA8 20207157 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG170458|UniProtKB=T1F332 T1F332 20203231 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG161625|UniProtKB=T1ERQ2 T1ERQ2 20199252 PTHR23249:SF16 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1 localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987 protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;vesicle tethering complex#GO:0099023;TRAPP complex#GO:0030008 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG68489|UniProtKB=T1FZF4 T1FZF4 20214202 PTHR12847:SF9 ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED NECAP-LIKE PROTEIN CG9132 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;transport#GO:0006810 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;clathrin vesicle coat#GO:0030125;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;vesicle membrane#GO:0012506;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;vesicle coat#GO:0030120;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;clathrin-coated vesicle#GO:0030136;protein-containing complex#GO:0032991;membrane coat#GO:0030117;coated vesicle membrane#GO:0030662;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;coated membrane#GO:0048475;cytoplasmic vesicle membrane#GO:0030659 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG170325|UniProtKB=T1F2X5 T1F2X5 20203174 PTHR45697:SF2 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2 carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein folding#GO:0006457;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG65162|UniProtKB=T1FY39 T1FY39 20213737 PTHR11675:SF131 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 9-RELATED transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG72135|UniProtKB=T1G0W4 T1G0W4 20214712 PTHR24399:SF41 ZINC FINGER AND BTB DOMAIN-CONTAINING ZINC FINGER PROTEIN GFI-1B cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription repressor activity#GO:0001217;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG186556|UniProtKB=T1FP11 T1FP11 20210558 PTHR20852:SF57 GLUTAMINE SYNTHETASE GLUTAMINE SYNTHETASE 2 CYTOPLASMIC ligase activity#GO:0016874;catalytic activity#GO:0003824 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;proteinogenic amino acid biosynthetic process#GO:0170038;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;alpha-amino acid biosynthetic process#GO:1901607;nitrogen compound metabolic process#GO:0006807;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;small molecule biosynthetic process#GO:0044283;L-amino acid biosynthetic process#GO:0170034;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 Glutamine glutamate conversion#P02745>Glutamine synthase#P04483;Glutamine glutamate conversion#P02745>Glutamine synthetase#P02968 HELRO|EnsemblGenome=HelroG110355|UniProtKB=T1EF17 T1EF17 20195169 PTHR12552:SF1 OLIGOPHRENIN 1 RHO GTPASE-ACTIVATING PROTEIN GRAF nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;GTPase regulator activity#GO:0030695;molecular function activator activity#GO:0140677;GTPase activator activity#GO:0005096;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 PDGF signaling pathway#P00047>Rho#P01174 HELRO|EnsemblGenome=HelroG168515|UniProtKB=T1F0N4 T1F0N4 20202384 PTHR12478:SF16 DNA-DAMAGE-INDUCIBLE TRANSCRIPT 4 PROTEIN DDIT4 PROTEIN CHARYBDE-RELATED regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;apoptotic process#GO:0006915;regulation of signaling#GO:0023051;biological regulation#GO:0065007;cell death#GO:0008219;programmed cell death#GO:0012501;cellular process#GO:0009987;regulation of intracellular signal transduction#GO:1902531;regulation of TOR signaling#GO:0032006 HELRO|EnsemblGenome=HelroG155141|UniProtKB=T1ELH2 T1ELH2 20197422 PTHR18860:SF17 14-3-3 PROTEIN 14-3-3 PROTEIN EPSILON localization#GO:0051179;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular localization#GO:0051641;cellular response to stimulus#GO:0051716;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052;protein localization#GO:0008104 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 Parkinson disease#P00049>14-3-3#P01238;FGF signaling pathway#P00021>14-3-3#P00624;EGF receptor signaling pathway#P00018>14-3-3#P00539 HELRO|EnsemblGenome=HelroG170076|UniProtKB=T1F2L8 T1F2L8 20203067 PTHR21461:SF69 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 glycosylation#GO:0070085;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG186826|UniProtKB=T1FP39 T1FP39 20210586 PTHR24351:SF216 RIBOSOMAL PROTEIN S6 KINASE PROTEIN KINASE C transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG109869|UniProtKB=T1EEX0 T1EEX0 20195122 PTHR21646:SF14 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE FI05488P cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG188502|UniProtKB=T1FQ22 T1FQ22 20210919 PTHR23252:SF24 INTIMAL THICKNESS RECEPTOR-RELATED TRANSMEMBRANE PROTEIN 145 HELRO|EnsemblGenome=HelroG161770|UniProtKB=T1ERW2 T1ERW2 20199312 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG189358|UniProtKB=T1FR00 T1FR00 20211247 PTHR44461:SF1 QUINONE OXIDOREDUCTASE-LIKE PROTEIN 1 QUINONE OXIDOREDUCTASE-LIKE PROTEIN 1 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG65928|UniProtKB=T1FYE4 T1FYE4 20213842 PTHR11537:SF113 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;delayed rectifier potassium channel activity#GO:0005251;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG191272|UniProtKB=T1FST8 T1FST8 20211885 PTHR12085:SF3 SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT GAMMA SERINE_THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT GAMMA cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cortical cytoskeleton organization#GO:0030865;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;spindle#GO:0005819;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG69371|UniProtKB=T1FZU0 T1FZU0 20214338 PTHR45870:SF2 TUBULIN MONOGLYCYLASE TTLL3 TUBULIN MONOGLYCYLASE TTLL3 ligase activity#GO:0016874;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG192841|UniProtKB=T1FUC7 T1FUC7 20212423 PTHR24403:SF67 ZINC FINGER PROTEIN FI01116P-RELATED regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG108114|UniProtKB=T1EEF6 T1EEF6 20194958 PTHR11097:SF8 EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN EXOSOME COMPLEX COMPONENT RRP42 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159;mRNA 3'-UTR binding#GO:0003730 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular nitrogen compound catabolic process#GO:0044270;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;organic cyclic compound metabolic process#GO:1901360;rRNA metabolic process#GO:0016072;nitrogen compound metabolic process#GO:0006807;organic cyclic compound catabolic process#GO:1901361;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;organic substance catabolic process#GO:1901575;nucleobase-containing compound catabolic process#GO:0034655;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;exosome (RNase complex)#GO:0000178;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;exoribonuclease#PC00099 HELRO|EnsemblGenome=HelroG187232|UniProtKB=T1FP80 T1FP80 20210627 PTHR21257:SF52 DELTA(14)-STEROL REDUCTASE DELTA(14)-STEROL REDUCTASE TM7SF2 oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor#GO:0016628 sterol metabolic process#GO:0016125;organic hydroxy compound metabolic process#GO:1901615;steroid metabolic process#GO:0008202;lipid metabolic process#GO:0006629;organic cyclic compound metabolic process#GO:1901360;organic hydroxy compound biosynthetic process#GO:1901617;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;lipid biosynthetic process#GO:0008610;steroid biosynthetic process#GO:0006694;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;sterol biosynthetic process#GO:0016126;metabolic process#GO:0008152 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG168671|UniProtKB=T1F0U6 T1F0U6 20202446 PTHR12429:SF8 NEURALIZED NEURALIZED-LIKE PROTEIN 2 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Notch signaling pathway#P00045>Neuralized#P01117 HELRO|EnsemblGenome=HelroG188744|UniProtKB=T1FQB7 T1FQB7 20211014 PTHR12276:SF45 EPSIN/ENT-RELATED CLATHRIN INTERACTOR 1 protein binding#GO:0005515;lipid binding#GO:0008289;clathrin binding#GO:0030276;phospholipid binding#GO:0005543;binding#GO:0005488 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;import into cell#GO:0098657;transport#GO:0006810;endocytosis#GO:0006897 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;clathrin vesicle coat#GO:0030125;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;vesicle coat#GO:0030120;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;clathrin-coated vesicle#GO:0030136;endomembrane system#GO:0012505;membrane coat#GO:0030117;coated vesicle membrane#GO:0030662;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;coated membrane#GO:0048475;cytoplasmic vesicle membrane#GO:0030659;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG188314|UniProtKB=T1FPV3 T1FPV3 20210850 PTHR10288:SF171 KH DOMAIN CONTAINING RNA BINDING PROTEIN P-ELEMENT SOMATIC INHIBITOR, ISOFORM C nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG190418|UniProtKB=T1FRZ4 T1FRZ4 20211591 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG182241|UniProtKB=T1FHZ4 T1FHZ4 20208443 PTHR11481:SF60 IMMUNOGLOBULIN FC RECEPTOR IG-LIKE DOMAIN-CONTAINING PROTEIN external side of plasma membrane#GO:0009897;cell surface#GO:0009986;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;side of membrane#GO:0098552;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124 HELRO|EnsemblGenome=HelroG166715|UniProtKB=T1EYF1 T1EYF1 20201601 PTHR42264:SF3 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN F-BOX DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG174580|UniProtKB=T1F899 T1F899 20205048 PTHR48032:SF18 RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6 RRM DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG159991|UniProtKB=T1EPM6 T1EPM6 20198526 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG160843|UniProtKB=T1EQT3 T1EQT3 20198933 PTHR23292:SF6 LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR FI16602P1-RELATED cation binding#GO:0043169;metal ion binding#GO:0046872;ion binding#GO:0043167;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;binding#GO:0005488;transition metal ion binding#GO:0046914 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG67876|UniProtKB=T1FZ67 T1FZ67 20214115 PTHR24343:SF330 SERINE/THREONINE KINASE SNF1-ACTIVATING KINASE 1 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG88134|UniProtKB=T1G6Y8 T1G6Y8 20216835 PTHR10024:SF344 SYNAPTOTAGMIN SYNAPTOTAGMIN-7 cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;phosphatidylserine binding#GO:0001786;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;protein binding#GO:0005515;clathrin binding#GO:0030276;lipid binding#GO:0008289;ion binding#GO:0043167;phospholipid binding#GO:0005543;SNARE binding#GO:0000149 vesicle fusion#GO:0006906;cellular localization#GO:0051641;synaptic vesicle cycle#GO:0099504;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;regulated exocytosis#GO:0045055;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;secretion#GO:0046903;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;signal release#GO:0023061;vesicle organization#GO:0016050;calcium-ion regulated exocytosis#GO:0017156;signaling#GO:0023052;cell-cell signaling#GO:0007267;synaptic vesicle exocytosis#GO:0016079;organelle fusion#GO:0048284;secretion by cell#GO:0032940;neurotransmitter secretion#GO:0007269;trans-synaptic signaling#GO:0099537;vesicle-mediated transport#GO:0016192;cell communication#GO:0007154;cellular component organization#GO:0016043;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;membrane fusion#GO:0061025;signal release from synapse#GO:0099643;exocytosis#GO:0006887;organelle organization#GO:0006996;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;export from cell#GO:0140352;vesicle-mediated transport in synapse#GO:0099003 synapse#GO:0045202;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;axon#GO:0030424;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;neuron projection#GO:0043005;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;transport vesicle#GO:0030133;cell projection#GO:0042995;secretory vesicle#GO:0099503;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG63394|UniProtKB=T1FXF3 T1FXF3 20213501 PTHR34095:SF1 39S RIBOSOMAL PROTEIN L55, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN ML55 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrial large ribosomal subunit#GO:0005762;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;organellar ribosome#GO:0000313;protein-containing complex#GO:0032991;large ribosomal subunit#GO:0015934;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840;mitochondrial protein-containing complex#GO:0098798 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG185770|UniProtKB=T1FN97 T1FN97 20210295 PTHR46367:SF1 ATAXIN-7-LIKE PROTEIN 3 ATAXIN-7-LIKE PROTEIN 3 transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 SAGA-type complex#GO:0070461;peptidase complex#GO:1905368;histone acetyltransferase complex#GO:0000123;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;acetyltransferase complex#GO:1902493;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;chromosome#GO:0005694;SAGA complex#GO:0000124;membrane-bounded organelle#GO:0043227;DUBm complex#GO:0071819;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG166800|UniProtKB=T1EYJ5 T1EYJ5 20201645 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG156279|UniProtKB=T1ELT7 T1ELT7 20197537 PTHR24023:SF1105 COLLAGEN ALPHA FIBRILLAR COLLAGEN NC1 DOMAIN-CONTAINING PROTEIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG192383|UniProtKB=T1FTW1 T1FTW1 20212258 PTHR16484:SF17 PARTITIONING DEFECTIVE 3 RELATED BAZOOKA, ISOFORM B lipid binding#GO:0008289;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;binding#GO:0005488 establishment or maintenance of cell polarity#GO:0007163;cellular localization#GO:0051641;organelle localization#GO:0051640;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;macromolecule localization#GO:0033036;microtubule cytoskeleton organization#GO:0000226;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cellular process#GO:0009987;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of cell polarity#GO:0030010;cellular macromolecule localization#GO:0070727;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;organelle organization#GO:0006996;centrosome localization#GO:0051642;establishment of localization in cell#GO:0051649;establishment or maintenance of apical/basal cell polarity#GO:0035088;cytoskeleton organization#GO:0007010;establishment or maintenance of bipolar cell polarity#GO:0061245;establishment of organelle localization#GO:0051656 cytoplasm#GO:0005737;anchoring junction#GO:0070161;cell-cell junction#GO:0005911;cell junction#GO:0030054;plasma membrane region#GO:0098590;adherens junction#GO:0005912;cell cortex#GO:0005938;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886;apical junction complex#GO:0043296;apical part of cell#GO:0045177;intracellular anatomical structure#GO:0005622;apical plasma membrane#GO:0016324 HELRO|EnsemblGenome=HelroG163371|UniProtKB=T1ETY8 T1ETY8 20200038 PTHR10024:SF227 SYNAPTOTAGMIN SYNAPTOTAGMIN 1 cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;phosphatidylserine binding#GO:0001786;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;protein binding#GO:0005515;clathrin binding#GO:0030276;lipid binding#GO:0008289;ion binding#GO:0043167;phospholipid binding#GO:0005543;SNARE binding#GO:0000149 cellular localization#GO:0051641;synaptic vesicle cycle#GO:0099504;synaptic vesicle endocytosis#GO:0048488;transport#GO:0006810;regulation of biological process#GO:0050789;regulated exocytosis#GO:0045055;synaptic vesicle recycling#GO:0036465;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;secretion#GO:0046903;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;signal release#GO:0023061;calcium-ion regulated exocytosis#GO:0017156;cell-cell signaling#GO:0007267;signaling#GO:0023052;synaptic vesicle exocytosis#GO:0016079;secretion by cell#GO:0032940;neurotransmitter secretion#GO:0007269;endocytosis#GO:0006897;trans-synaptic signaling#GO:0099537;vesicle-mediated transport#GO:0016192;cell communication#GO:0007154;cellular process#GO:0009987;localization#GO:0051179;signal release from synapse#GO:0099643;exocytosis#GO:0006887;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;import into cell#GO:0098657;export from cell#GO:0140352;vesicle-mediated transport in synapse#GO:0099003 intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;secretory vesicle#GO:0099503;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG72082|UniProtKB=T1G0V3 T1G0V3 20214701 PTHR12391:SF0 ARP2/3 COMPLEX 21 KD SUBUNIT ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 3 cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;Arp2/3 complex-mediated actin nucleation#GO:0034314;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;Arp2/3 protein complex#GO:0005885;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Integrin signalling pathway#P00034>Arp2/3#P00912;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Arp2/3#P00876;Cytoskeletal regulation by Rho GTPase#P00016>ARP2/3#P00511 HELRO|EnsemblGenome=HelroG190743|UniProtKB=T1FS91 T1FS91 20211688 PTHR11785:SF528 AMINO ACID TRANSPORTER AMINO ACID TRANSPORTER PROTEIN JHI-21 L-amino acid transmembrane transporter activity#GO:0015179;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;amino acid transport#GO:0006865;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;nitrogen compound transport#GO:0071705;organic acid transmembrane transport#GO:1903825;carboxylic acid transport#GO:0046942;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039 transporter#PC00227 HELRO|EnsemblGenome=HelroG114561|UniProtKB=T1EG30 T1EG30 20195532 PTHR19308:SF53 PHOSPHATIDYLCHOLINE TRANSFER PROTEIN CERAMIDE TRANSFER PROTEIN amide transport#GO:0042886;localization#GO:0051179;organic substance transport#GO:0071702;cellular localization#GO:0051641;establishment of localization#GO:0051234;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;lipid localization#GO:0010876;cellular process#GO:0009987;lipid transport#GO:0006869;intracellular lipid transport#GO:0032365 HELRO|EnsemblGenome=HelroG189604|UniProtKB=T1FR70 T1FR70 20211317 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG194530|UniProtKB=T1FW57 T1FW57 20213053 PTHR15427:SF33 EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG161457|UniProtKB=T1ERH6 T1ERH6 20199176 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183676|UniProtKB=T1FK09 T1FK09 20209158 PTHR20956:SF12 HEH2P FLYWCH-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77693|UniProtKB=T1G324 T1G324 20215472 PTHR13271:SF151 UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE SET DOMAIN-CONTAINING PROTEIN 4 N-methyltransferase activity#GO:0008170;transferase activity#GO:0016740;catalytic activity#GO:0003824;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;protein-lysine N-methyltransferase activity#GO:0016279;catalytic activity, acting on a protein#GO:0140096;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;lysine N-methyltransferase activity#GO:0016278;protein methyltransferase activity#GO:0008276 macromolecule methylation#GO:0043414;methylation#GO:0032259;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 transferase#PC00220;methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG112716|UniProtKB=T1EFL5 T1EFL5 20195367 PTHR14795:SF0 HELICASE RELATED TRANSMEMBRANE PROTEIN 62 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG65737|UniProtKB=T1FYC1 T1FYC1 20213819 PTHR20978:SF0 SPLICING FACTOR 3B SUBUNIT 5 SPLICING FACTOR 3B SUBUNIT 5 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;protein-containing complex#GO:0032991;small nuclear ribonucleoprotein complex#GO:0030532;U2 snRNP#GO:0005686;membrane-bounded organelle#GO:0043227;precatalytic spliceosome#GO:0071011;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG162523|UniProtKB=T1ESS7 T1ESS7 20199627 PTHR45986:SF1 ZINC FINGER MATRIN-TYPE PROTEIN 2 ZINC FINGER MATRIN-TYPE PROTEIN 2 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;spliceosomal tri-snRNP complex#GO:0097526;U4/U6 x U5 tri-snRNP complex#GO:0046540;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG170905|UniProtKB=T1F3K9 T1F3K9 20203408 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168419|UniProtKB=T1F0K5 T1F0K5 20202355 PTHR44305:SF2 SI:DKEY-192D15.2-RELATED SI:DKEY-192D15.2 HELRO|EnsemblGenome=HelroG125204|UniProtKB=T1EH49 T1EH49 20195899 PTHR24193:SF121 ANKYRIN REPEAT PROTEIN ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D HELRO|EnsemblGenome=HelroG161929|UniProtKB=T1ES18 T1ES18 20199368 PTHR15889:SF2 MITOCHONDRIAL RIBOSOMAL PROTEIN L37 LARGE RIBOSOMAL SUBUNIT PROTEIN ML37 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG82965|UniProtKB=T1G4Y5 T1G4Y5 20216133 PTHR23116:SF36 PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED HARMONIN stereocilium#GO:0032420;stereocilium bundle#GO:0032421;protein-containing complex#GO:0032991;cluster of actin-based cell projections#GO:0098862;neuron projection#GO:0043005;membrane-bounded organelle#GO:0043227;actin-based cell projection#GO:0098858;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;cell periphery#GO:0071944;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;membrane#GO:0016020;cilium#GO:0005929;plasma membrane#GO:0005886 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG79043|UniProtKB=T1G3J1 T1G3J1 20215639 PTHR19229:SF250 ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;lipid transporter activity#GO:0005319;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;organic substance transport#GO:0071702;lipid localization#GO:0010876;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;lipid transport#GO:0006869;transport#GO:0006810 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG163911|UniProtKB=T1EUM0 T1EUM0 20200270 PTHR11188:SF17 ARRESTIN DOMAIN CONTAINING PROTEIN FI21816P1 localization#GO:0051179;organic substance transport#GO:0071702;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;protein transport#GO:0015031;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG110878|UniProtKB=T1EF60 T1EF60 20195212 PTHR11073:SF1 CALRETICULIN AND CALNEXIN CALNEXIN 14D-RELATED cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 protein catabolic process#GO:0030163;gene expression#GO:0010467;organonitrogen compound catabolic process#GO:1901565;biosynthetic process#GO:0009058;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;macromolecule catabolic process#GO:0009057;response to endoplasmic reticulum stress#GO:0034976;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;protein maturation#GO:0051604;ERAD pathway#GO:0036503;cellular biosynthetic process#GO:0044249;response to organonitrogen compound#GO:0010243;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;protein folding#GO:0006457;cellular response to stress#GO:0033554 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG63336|UniProtKB=T1FXE4 T1FXE4 20213492 PTHR11909:SF300 CASEIN KINASE-RELATED TAU-TUBULIN KINASE HOMOLOG ASATOR transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Parkinson disease#P00049>Casein kinase I#P01242 HELRO|EnsemblGenome=HelroG189813|UniProtKB=T1FRE0 T1FRE0 20211387 PTHR11472:SF47 DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER FANCONI ANEMIA GROUP J PROTEIN ATP-dependent activity, acting on DNA#GO:0008094;catalytic activity, acting on a nucleic acid#GO:0140640;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;double-strand break repair#GO:0006302;nuclear division#GO:0000280;cell cycle process#GO:0022402;nucleobase-containing compound metabolic process#GO:0006139;reciprocal homologous recombination#GO:0140527;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;meiotic cell cycle process#GO:1903046;meiosis I cell cycle process#GO:0061982;reproductive process#GO:0022414;reciprocal meiotic recombination#GO:0007131;meiosis I#GO:0007127;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;nucleotide-excision repair#GO:0006289;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;meiotic cell cycle#GO:0051321;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;reproduction#GO:0000003;response to stress#GO:0006950;meiotic nuclear division#GO:0140013;organelle organization#GO:0006996;sexual reproduction#GO:0019953;cell cycle#GO:0007049;organelle fission#GO:0048285;homologous recombination#GO:0035825;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA helicase#PC00011;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG167586|UniProtKB=T1EZI8 T1EZI8 20201988 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG161126|UniProtKB=T1ER43 T1ER43 20199043 PTHR10219:SF25 GLYCOLIPID TRANSFER PROTEIN-RELATED PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8 lipid transfer activity#GO:0120013;small molecule binding#GO:0036094;binding#GO:0005488;amide binding#GO:0033218;phospholipid transporter activity#GO:0005548;lipid binding#GO:0008289;ion binding#GO:0043167;anion binding#GO:0043168;phospholipid binding#GO:0005543;transporter activity#GO:0005215;lipid transporter activity#GO:0005319 amide transport#GO:0042886;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;membrane organization#GO:0061024;transport#GO:0006810;nitrogen compound transport#GO:0071705;cellular component organization#GO:0016043;lipid localization#GO:0010876;intermembrane lipid transfer#GO:0120009;cellular process#GO:0009987;lipid transport#GO:0006869 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG132800|UniProtKB=T1EHZ7 T1EHZ7 20196197 PTHR22883:SF488 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular localization#GO:0051641;macromolecule localization#GO:0033036;macromolecule modification#GO:0043412;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;protein palmitoylation#GO:0018345;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;localization within membrane#GO:0051668;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein localization to membrane#GO:0072657;organonitrogen compound biosynthetic process#GO:1901566;protein targeting#GO:0006605;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;protein acylation#GO:0043543;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipoprotein biosynthetic process#GO:0042158;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;lipoprotein metabolic process#GO:0042157 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG182127|UniProtKB=T1FHT0 T1FHT0 20208379 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG75449|UniProtKB=T1G253 T1G253 20215151 PTHR45997:SF1 DNA LIGASE 4 DNA LIGASE 4 carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;nucleic acid binding#GO:0003676;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;catalytic activity, acting on DNA#GO:0140097;anion binding#GO:0043168;ion binding#GO:0043167;ATP binding#GO:0005524 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;nucleotide-excision repair#GO:0006289;cellular response to stimulus#GO:0051716;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;double-strand break repair via nonhomologous end joining#GO:0006303;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;response to stress#GO:0006950;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;metabolic process#GO:0008152 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG164224|UniProtKB=T1FKU0 T1FKU0 20200444 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG64188|UniProtKB=T1FXR1 T1FXR1 20213609 PTHR12378:SF7 DESUMOYLATING ISOPEPTIDASE DESUMOYLATING ISOPEPTIDASE 1 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein modification by small protein removal#GO:0070646;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238;metabolic process#GO:0008152 cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG104628|UniProtKB=T1EDM7 T1EDM7 20194679 PTHR47960:SF17 DEAD-BOX ATP-DEPENDENT RNA HELICASE 50 ATP-DEPENDENT RNA HELICASE DDX6-RELATED nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;cellular component biogenesis#GO:0044085;negative regulation of biological process#GO:0048519;regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;non-membrane-bounded organelle assembly#GO:0140694;P-body assembly#GO:0033962;negative regulation of cellular process#GO:0048523;cellular component assembly#GO:0022607;negative regulation of biosynthetic process#GO:0009890;cellular component organization#GO:0016043;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;cellular process#GO:0009987;negative regulation of nitrogen compound metabolic process#GO:0051172;organelle assembly#GO:0070925;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of translation#GO:0017148;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;organelle organization#GO:0006996;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;P-body#GO:0000932;cytoplasmic stress granule#GO:0010494;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG153373|UniProtKB=T1EL56 T1EL56 20197368 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190514|UniProtKB=T1FS24 T1FS24 20211621 PTHR15723:SF0 CARBOHYDRATE SULFOTRANSFERASE 15 CARBOHYDRATE SULFOTRANSFERASE 15 sulfotransferase activity#GO:0008146;transferase activity#GO:0016740;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity#GO:0003824 hexose biosynthetic process#GO:0019319;monosaccharide metabolic process#GO:0005996;carbohydrate biosynthetic process#GO:0016051;small molecule biosynthetic process#GO:0044283;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;hexose metabolic process#GO:0019318;carbohydrate metabolic process#GO:0005975;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG129847|UniProtKB=T1EHS6 T1EHS6 20196126 PTHR13140:SF857 MYOSIN MYOSIN-11 microfilament motor activity#GO:0000146;cytoskeletal protein binding#GO:0008092;ATP-dependent activity#GO:0140657;binding#GO:0005488;actin filament binding#GO:0051015;cytoskeletal motor activity#GO:0003774;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG189931|UniProtKB=T1FRH9 T1FRH9 20211426 PTHR13437:SF2 NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1 NUCLEOPORIN P58_P45 signal sequence binding#GO:0005048;structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056;binding#GO:0005488;peptide binding#GO:0042277;amide binding#GO:0033218 envelope#GO:0031975;nuclear pore#GO:0005643;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG185809|UniProtKB=T1FNB5 T1FNB5 20210312 PTHR11581:SF0 30S/40S RIBOSOMAL PROTEIN S4 SMALL RIBOSOMAL SUBUNIT PROTEIN ES4 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;cytosol#GO:0005829;small ribosomal subunit#GO:0015935;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG162069|UniProtKB=T1ES81 T1ES81 20199431 PTHR21505:SF8 MADF DOMAIN-CONTAINING PROTEIN-RELATED DPT-YFP REPRESSOR BY OVEREXPRESSION, ISOFORM D-RELATED HELRO|EnsemblGenome=HelroG81180|UniProtKB=T1G4A7 T1G4A7 20215905 PTHR46152:SF3 NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN protein binding#GO:0005515;binding#GO:0005488 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052 HELRO|EnsemblGenome=HelroG182938|UniProtKB=T1FIY1 T1FIY1 20208780 PTHR11759:SF3 40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11 SMALL RIBOSOMAL SUBUNIT PROTEIN US11M ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG67123|UniProtKB=T1FYW7 T1FYW7 20214015 PTHR19957:SF224 SYNTAXIN HL02043P molecular adaptor activity#GO:0060090;protein binding#GO:0005515;SNAP receptor activity#GO:0005484;binding#GO:0005488;SNARE binding#GO:0000149;protein-macromolecule adaptor activity#GO:0030674 vesicle fusion#GO:0006906;cellular localization#GO:0051641;organelle localization#GO:0051640;macromolecule localization#GO:0033036;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;membrane fusion#GO:0061025;establishment of localization#GO:0051234;organelle organization#GO:0006996;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;vesicle organization#GO:0016050;intracellular transport#GO:0046907;organelle fusion#GO:0048284 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;SNARE complex#GO:0031201;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034;membrane traffic protein#PC00150 Alpha adrenergic receptor signaling pathway#P00002>SNARE#P00074 HELRO|EnsemblGenome=HelroG193469|UniProtKB=T1FV11 T1FV11 20212657 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG115219|UniProtKB=T1EG73 T1EG73 20195575 PTHR11254:SF395 HECT DOMAIN UBIQUITIN-PROTEIN LIGASE E3 UBIQUITIN-PROTEIN LIGASE SMURF1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 negative regulation of biological process#GO:0048519;macromolecule modification#GO:0043412;regulation of signaling#GO:0023051;protein catabolic process#GO:0030163;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;regulation of biological process#GO:0050789;regulation of BMP signaling pathway#GO:0030510;modification-dependent macromolecule catabolic process#GO:0043632;negative regulation of BMP signaling pathway#GO:0030514;nitrogen compound metabolic process#GO:0006807;regulation of signal transduction#GO:0009966;proteolysis#GO:0006508;regulation of cellular response to growth factor stimulus#GO:0090287;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;negative regulation of cellular process#GO:0048523;proteolysis involved in protein catabolic process#GO:0051603;negative regulation of cell communication#GO:0010648;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;regulation of cell communication#GO:0010646;macromolecule catabolic process#GO:0009057;protein ubiquitination#GO:0016567;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation or removal#GO:0070647;negative regulation of response to stimulus#GO:0048585;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;negative regulation of signaling#GO:0023057;organonitrogen compound metabolic process#GO:1901564;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;regulation of response to stimulus#GO:0048583;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 SCW signaling pathway#P06216>LACK#P06321;Activin beta signaling pathway#P06210>LACK#P06230;DPP signaling pathway#P06213>LACK#P06278;TGF-beta signaling pathway#P00052>Smurfs#P01279;BMP/activin signaling pathway-drosophila#P06211>Smurf#P06243;ALP23B signaling pathway#P06209>LACK#P06219;DPP-SCW signaling pathway#P06212>LACK#P06269;GBB signaling pathway#P06214>LACK#P06303;MYO signaling pathway#P06215>LACK#P06309 HELRO|EnsemblGenome=HelroG169248|UniProtKB=T1F1M7 T1F1M7 20202727 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177042|UniProtKB=T1FB63 T1FB63 20206062 PTHR12881:SF10 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1 molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG190526|UniProtKB=T1FS26 T1FS26 20211623 PTHR24213:SF9 ACTIN-BINDING LIM PROTEIN UNCOORDINATED 115A, ISOFORM B-RELATED cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cell projection organization#GO:0030030;cellular component organization#GO:0016043;plasma membrane bounded cell projection assembly#GO:0120031;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Axon guidance mediated by netrin#P00009>Ablim#P00358 HELRO|EnsemblGenome=HelroG184035|UniProtKB=T1FKG8 T1FKG8 20209317 PTHR13351:SF1 RENIN RECEPTOR RENIN RECEPTOR external side of plasma membrane#GO:0009897;cell surface#GO:0009986;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;side of membrane#GO:0098552;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG157126|UniProtKB=T1EM67 T1EM67 20197667 PTHR47980:SF23 LD44762P RAB10, MEMBER RAS ONCOGENE FAMILY cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;myosin binding#GO:0017022;binding#GO:0005488 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;protein secretion#GO:0009306;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;establishment of protein localization to extracellular region#GO:0035592;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;protein transport#GO:0015031;protein localization to extracellular region#GO:0071692;export from cell#GO:0140352;secretion by cell#GO:0032940 endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;recycling endosome#GO:0055037;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;secretory vesicle#GO:0099503 TGF-beta signaling pathway#P00052>Ras-GDP#P01291;TGF-beta signaling pathway#P00052>Ras-GTP#P01280 HELRO|EnsemblGenome=HelroG183936|UniProtKB=T1FKB6 T1FKB6 20209265 PTHR46186:SF2 CYSTATIN CYSTATIN peptidase inhibitor activity#GO:0030414;molecular function regulator activity#GO:0098772;cysteine-type endopeptidase inhibitor activity#GO:0004869;peptidase regulator activity#GO:0061134;enzyme inhibitor activity#GO:0004857;endopeptidase regulator activity#GO:0061135;endopeptidase inhibitor activity#GO:0004866;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 regulation of proteolysis#GO:0030162;negative regulation of hydrolase activity#GO:0051346;negative regulation of biological process#GO:0048519;regulation of protein metabolic process#GO:0051246;regulation of cysteine-type endopeptidase activity#GO:2000116;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of cysteine-type endopeptidase activity#GO:2000117;negative regulation of peptidase activity#GO:0010466;negative regulation of endopeptidase activity#GO:0010951;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of proteolysis#GO:0045861;regulation of catalytic activity#GO:0050790;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of molecular function#GO:0065009;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336;regulation of endopeptidase activity#GO:0052548;regulation of peptidase activity#GO:0052547;negative regulation of catalytic activity#GO:0043086;regulation of metabolic process#GO:0019222;negative regulation of molecular function#GO:0044092 cytoplasm#GO:0005737;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG103068|UniProtKB=T1EDE1 T1EDE1 20194593 PTHR10953:SF186 UBIQUITIN-ACTIVATING ENZYME E1 UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 6 ligase activity#GO:0016874;transferase activity#GO:0016740;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877;nucleotidyltransferase activity#GO:0016779;thiosulfate sulfurtransferase activity#GO:0004792;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity, acting on a protein#GO:0140096;sulfurtransferase activity#GO:0016783 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;cellular process#GO:0009987;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;response to stimulus#GO:0050896;DNA damage response#GO:0006974;response to stress#GO:0006950;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E1#P01492 HELRO|EnsemblGenome=HelroG178476|UniProtKB=T1FD83 T1FD83 20206782 PTHR46123:SF4 MIX-TYPE HOMEOBOX GENE 1-RELATED MIX-TYPE HOMEOBOX GENE 1-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG62045|UniProtKB=T1FWU5 T1FWU5 20213293 PTHR24083:SF103 NUCLEAR HORMONE RECEPTOR PROTEIN ULTRASPIRACLE cis-regulatory region sequence-specific DNA binding#GO:0000987;signaling receptor activity#GO:0038023;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;anatomical structure development#GO:0048856;biological regulation#GO:0065007;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG191013|UniProtKB=T1FSI0 T1FSI0 20211777 PTHR12673:SF159 FACIOGENITAL DYSPLASIA PROTEIN LD03170P nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG182898|UniProtKB=T1FIW7 T1FIW7 20208766 PTHR31336:SF3 LIN37 HOMOLOG PROTEIN LIN-37 HOMOLOG HELRO|EnsemblGenome=HelroG66166|UniProtKB=T1FYH8 T1FYH8 20213876 PTHR11679:SF30 VESICLE PROTEIN SORTING-ASSOCIATED PROTEIN ROP syntaxin binding#GO:0019905;protein binding#GO:0005515;binding#GO:0005488;SNARE binding#GO:0000149 cellular localization#GO:0051641;organelle localization#GO:0051640;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;exocytic process#GO:0140029;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;export from cell#GO:0140352;secretion by cell#GO:0032940 intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;secretory granule#GO:0030141;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;secretory vesicle#GO:0099503;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG77273|UniProtKB=T1G2V5 T1G2V5 20215403 PTHR11920:SF501 GUANYLYL CYCLASE GUANYLATE CYCLASE 32E adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG93853|UniProtKB=T1G8Y0 T1G8Y0 20217527 PTHR24413:SF213 SPECKLE-TYPE POZ PROTEIN FI01029P-RELATED enzyme binding#GO:0019899;protein binding#GO:0005515;ubiquitin protein ligase binding#GO:0031625;binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389 regulation of proteolysis#GO:0030162;macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;regulation of protein metabolic process#GO:0051246;macromolecule metabolic process#GO:0043170;regulation of nitrogen compound metabolic process#GO:0051171;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of biological process#GO:0050789;modification-dependent macromolecule catabolic process#GO:0043632;regulation of primary metabolic process#GO:0080090;regulation of macromolecule metabolic process#GO:0060255;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;biological regulation#GO:0065007;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;regulation of metabolic process#GO:0019222;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG121833|UniProtKB=T1EGS9 T1EGS9 20195779 PTHR19960:SF11 TEKTIN TEKTIN cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cilium or flagellum-dependent cell motility#GO:0001539;cell motility#GO:0048870;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;cilium movement involved in cell motility#GO:0060294;cilium movement#GO:0003341;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cilium-dependent cell motility#GO:0060285;microtubule-based process#GO:0007017;organelle organization#GO:0006996;plasma membrane bounded cell projection assembly#GO:0120031 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG166931|UniProtKB=T1EYR6 T1EYR6 20201716 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184959|UniProtKB=T1FM74 T1FM74 20209923 PTHR11276:SF42 DNA POLYMERASE TYPE-X FAMILY MEMBER DNA POLYMERASE BETA DNA-directed DNA polymerase activity#GO:0003887;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on DNA#GO:0140097;DNA polymerase activity#GO:0034061 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;base-excision repair#GO:0006284;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;double-strand break repair via nonhomologous end joining#GO:0006303;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;response to stress#GO:0006950;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-directed DNA polymerase#PC00018 HELRO|EnsemblGenome=HelroG182439|UniProtKB=T1FI72 T1FI72 20208521 PTHR25462:SF295 BONUS, ISOFORM C-RELATED B BOX-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG161987|UniProtKB=T1ES45 T1ES45 20199395 PTHR14596:SF76 ZINC FINGER PROTEIN DEFECTIVE CHORION PROTEIN, FC177 ISOFORM cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to nutrient levels#GO:0031667;response to extracellular stimulus#GO:0009991;response to stress#GO:0006950;response to starvation#GO:0042594 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG189047|UniProtKB=T1FQL2 T1FQL2 20211109 PTHR11216:SF176 EH DOMAIN EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY SUBSTRATE CLONE 15, ISOFORM A localization#GO:0051179;endosomal transport#GO:0016197;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;endocytosis#GO:0006897;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;cellular process#GO:0009987;import into cell#GO:0098657 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane coat#GO:0030117;plasma membrane protein complex#GO:0098797;coated membrane#GO:0048475;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;clathrin-coated pit#GO:0005905;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG134275|UniProtKB=T1EI38 T1EI38 20196238 PTHR24418:SF373 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE SRC42A protein tyrosine kinase activity#GO:0004713;non-membrane spanning protein tyrosine kinase activity#GO:0004715;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein binding#GO:0005515;catalytic activity, acting on a protein#GO:0140096;signaling receptor binding#GO:0005102;kinase activity#GO:0016301;protein kinase activity#GO:0004672 response to external biotic stimulus#GO:0043207;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;immune response#GO:0006955;developmental process#GO:0032502;cell communication#GO:0007154;cellular process#GO:0009987;defense response to symbiont#GO:0140546;regulation of biological process#GO:0050789;immune system process#GO:0002376;response to stimulus#GO:0050896;response to external stimulus#GO:0009605;cell differentiation#GO:0030154;enzyme-linked receptor protein signaling pathway#GO:0007167;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to other organism#GO:0098542;regulation of cellular process#GO:0050794;response to other organism#GO:0051707;cell surface receptor signaling pathway#GO:0007166;biological process involved in interspecies interaction between organisms#GO:0044419;biological regulation#GO:0065007;innate immune response#GO:0045087;defense response#GO:0006952;signaling#GO:0023052;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169 non-receptor tyrosine protein kinase#PC00168 Parkinson disease#P00049>Src kinase#P01230;Integrin signalling pathway#P00034>Src#P00940 HELRO|EnsemblGenome=HelroG170544|UniProtKB=T1F364 T1F364 20203263 PTHR47695:SF3 PID DOMAIN-CONTAINING PROTEIN PID DOMAIN-CONTAINING PROTEIN cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG99127|UniProtKB=T1G9R1 T1G9R1 20217807 PTHR14374:SF0 FOIE GRAS TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11 HELRO|EnsemblGenome=HelroG177898|UniProtKB=T1FCG0 T1FCG0 20206509 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG64786|UniProtKB=T1FXZ3 T1FXZ3 20213691 PTHR13068:SF112 CGI-12 PROTEIN-RELATED TRANSCRIPTION TERMINATION FACTOR 3, MITOCHONDRIAL HELRO|EnsemblGenome=HelroG160729|UniProtKB=T1EQN2 T1EQN2 20198882 PTHR14344:SF3 WD REPEAT PROTEIN WD REPEAT-CONTAINING PROTEIN 6 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;macromolecule methylation#GO:0043414;tRNA methylation#GO:0030488;organic cyclic compound metabolic process#GO:1901360;methylation#GO:0032259;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;RNA methylation#GO:0001510;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG95909|UniProtKB=T1G988 T1G988 20217635 PTHR42698:SF1 GTPASE ERA GTPASE ERA, MITOCHONDRIAL nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159;ribosome binding#GO:0043022;ribonucleoprotein complex binding#GO:0043021;protein-containing complex binding#GO:0044877;rRNA binding#GO:0019843 organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;protein-RNA complex assembly#GO:0022618;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;ribonucleoprotein complex biogenesis#GO:0022613;protein-containing complex assembly#GO:0065003;protein-RNA complex organization#GO:0071826;cellular component organization#GO:0016043;ribosome biogenesis#GO:0042254;cellular process#GO:0009987;non-membrane-bounded organelle assembly#GO:0140694;ribosomal small subunit biogenesis#GO:0042274 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG91744|UniProtKB=T1G883 T1G883 20217280 PTHR48112:SF32 HIGH MOBILITY GROUP PROTEIN DSP1 HIGH MOBILITY GROUP PROTEIN B3 HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG174575|UniProtKB=T1F896 T1F896 20205045 PTHR10283:SF82 SOLUTE CARRIER FAMILY 13 MEMBER SOLUTE CARRIER FAMILY 13 MEMBER 2 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG67100|UniProtKB=T1FYW4 T1FYW4 20214012 PTHR21083:SF0 TWISTER DYNEIN AXONEMAL ASSEMBLY FACTOR 6 protein binding#GO:0005515;binding#GO:0005488 cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;protein-containing complex assembly#GO:0065003;microtubule cytoskeleton organization#GO:0000226;cellular component organization#GO:0016043;axoneme assembly#GO:0035082;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection assembly#GO:0120031 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG191310|UniProtKB=T1FSV5 T1FSV5 20211902 PTHR24348:SF22 SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular component biogenesis#GO:0044085;regulation of catabolic process#GO:0009894;macroautophagy#GO:0016236;macromolecule modification#GO:0043412;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;cellular component assembly#GO:0022607;macromolecule metabolic process#GO:0043170;regulation of autophagy#GO:0010506;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;protein phosphorylation#GO:0006468;regulation of cellular catabolic process#GO:0031329;cellular process#GO:0009987;primary metabolic process#GO:0044238;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;regulation of cellular process#GO:0050794;organelle organization#GO:0006996;biological regulation#GO:0065007;autophagosome assembly#GO:0000045;peptidyl-serine modification#GO:0018209;autophagy#GO:0006914;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;phagophore assembly site#GO:0000407;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;autophagosome#GO:0005776;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG73106|UniProtKB=T1G1A3 T1G1A3 20214851 PTHR28630:SF31 FAMILY NOT NAMED PEROXIREDOXIN-LIKE 2A HELRO|EnsemblGenome=HelroG177869|UniProtKB=T1FCE3 T1FCE3 20206492 PTHR12242:SF45 OS02G0130600 PROTEIN-RELATED MARVEL DOMAIN-CONTAINING PROTEIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG181375|UniProtKB=T1FGX6 T1FGX6 20208075 PTHR24171:SF8 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;BRCA1-A complex#GO:0070531;nuclear ubiquitin ligase complex#GO:0000152;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG160782|UniProtKB=T1EQQ1 T1EQQ1 20198901 PTHR24133:SF40 ANKYRIN DOMAIN-CONTAINING ANKYRIN REPEAT DOMAIN 44 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG161459|UniProtKB=T1ERH7 T1ERH7 20199177 PTHR11731:SF200 PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED DIPEPTIDYL PEPTIDASE 10, ISOFORM B hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG79813|UniProtKB=T1G3T8 T1G3T8 20215736 PTHR10068:SF14 BONE MARROW PROTEOGLYCAN CELL WALL ADHESIN EAP1 extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG157531|UniProtKB=T1EMC6 T1EMC6 20197726 PTHR10507:SF0 CDC45-RELATED PROTEIN CELL DIVISION CONTROL PROTEIN 45 HOMOLOG sequence-specific double-stranded DNA binding#GO:1990837;DNA replication origin binding#GO:0003688;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;chromatin binding#GO:0003682;single-stranded DNA binding#GO:0003697;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;protein-containing complex binding#GO:0044877 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;double-strand break repair#GO:0006302;cell cycle process#GO:0022402;protein-containing complex assembly#GO:0065003;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;mitotic cell cycle process#GO:1903047;DNA damage response#GO:0006974;mitotic cell cycle#GO:0000278;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;recombinational repair#GO:0000725;DNA-templated DNA replication#GO:0006261;cell cycle DNA replication#GO:0044786;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;nuclear DNA replication#GO:0033260;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;double-strand break repair via homologous recombination#GO:0000724;cellular process#GO:0009987;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;double-strand break repair via break-induced replication#GO:0000727;protein-containing complex organization#GO:0043933;mitotic DNA replication#GO:1902969;cell cycle#GO:0007049;cellular response to stress#GO:0033554;DNA replication#GO:0006260;DNA replication initiation#GO:0006270;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;DNA replication preinitiation complex#GO:0031261;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 DNA metabolism protein#PC00009;replication origin binding protein#PC00199 HELRO|EnsemblGenome=HelroG79600|UniProtKB=T1G3Q6 T1G3Q6 20215704 PTHR24238:SF66 G-PROTEIN COUPLED RECEPTOR TACHYKININ-LIKE PEPTIDES RECEPTOR 86C signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;neuropeptide signaling pathway#GO:0007218;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG65637|UniProtKB=T1FYB0 T1FYB0 20213808 PTHR19960:SF25 TEKTIN TEKTIN-1 cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cilium or flagellum-dependent cell motility#GO:0001539;cell motility#GO:0048870;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;cilium movement involved in cell motility#GO:0060294;cilium movement#GO:0003341;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cilium-dependent cell motility#GO:0060285;microtubule-based process#GO:0007017;organelle organization#GO:0006996;plasma membrane bounded cell projection assembly#GO:0120031 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG167218|UniProtKB=T1EZ56 T1EZ56 20201856 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG184008|UniProtKB=T1FKE9 T1FKE9 20209298 PTHR10398:SF2 AFADIN AFADIN non-motor actin binding protein#PC00165 Alzheimer disease-presenilin pathway#P00004>Afadin#P00146 HELRO|EnsemblGenome=HelroG180700|UniProtKB=T1FG67 T1FG67 20207816 PTHR46228:SF2 KELCH DOMAIN-CONTAINING PROTEIN KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_4G14350) HELRO|EnsemblGenome=HelroG180986|UniProtKB=T1FGI0 T1FGI0 20207929 PTHR24193:SF121 ANKYRIN REPEAT PROTEIN ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D HELRO|EnsemblGenome=HelroG156580|UniProtKB=T1ELY7 T1ELY7 20197587 PTHR23073:SF13 26S PROTEASOME REGULATORY SUBUNIT 26S PROTEASOME REGULATORY SUBUNIT 7 ATP-dependent activity#GO:0140657 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 peptidase complex#GO:1905368;protein-containing complex#GO:0032991;proteasome accessory complex#GO:0022624;proteasome regulatory particle#GO:0005838;catalytic complex#GO:1902494;proteasome complex#GO:0000502;endopeptidase complex#GO:1905369;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 protease#PC00190;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG190661|UniProtKB=T1FS67 T1FS67 20211664 PTHR12913:SF1 UNR PROTEIN N-RAS UPSTREAM GENE PROTEIN COLD SHOCK DOMAIN-CONTAINING PROTEIN E1 HELRO|EnsemblGenome=HelroG170263|UniProtKB=T1F2U7 T1F2U7 20203146 PTHR10891:SF918 EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN CALCIUM-BINDING PROTEIN 2 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG174195|UniProtKB=T1F7R6 T1F7R6 20204865 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG87021|UniProtKB=T1G6K7 T1G6K7 20216704 PTHR22807:SF34 NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING TRNA (CYTOSINE(72)-C(5))-METHYLTRANSFERASE NSUN6 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;methylation#GO:0032259;macromolecule methylation#GO:0043414;nitrogen compound metabolic process#GO:0006807;RNA methylation#GO:0001510;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG100409|UniProtKB=T1ECZ6 T1ECZ6 20194448 PTHR13104:SF0 MED-6-RELATED MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 6 transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;core mediator complex#GO:0070847;RNA polymerase II transcription regulator complex#GO:0090575;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG112977|UniProtKB=T1EFP0 T1EFP0 20195392 PTHR45882:SF3 PITUITARY HOMEOBOX HOMOLOG PTX1 PITUITARY HOMEOBOX HOMOLOG PTX1 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;anatomical structure morphogenesis#GO:0009653;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG156550|UniProtKB=T1ELY1 T1ELY1 20197581 PTHR11675:SF119 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2 transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG120769|UniProtKB=T1EGQ6 T1EGQ6 20195756 PTHR19444:SF13 UNC-93 RELATED PROTEIN UNC-93 HOMOLOG A membrane-bound signaling molecule#PC00152 HELRO|EnsemblGenome=HelroG171221|UniProtKB=T1F3Y6 T1F3Y6 20203535 PTHR47055:SF3 DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 HELRO|EnsemblGenome=HelroG185121|UniProtKB=T1FMF4 T1FMF4 20210003 PTHR43157:SF31 PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG117118|UniProtKB=T1EGK3 T1EGK3 20195704 PTHR10194:SF142 RAS GTPASE-ACTIVATING PROTEINS NEUROFIBROMIN G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 EGF receptor signaling pathway#P00018>GAP#P00546 HELRO|EnsemblGenome=HelroG178667|UniProtKB=T1FDJ2 T1FDJ2 20206891 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG97508|UniProtKB=T1G9H5 T1G9H5 20217722 PTHR12131:SF1 ATP-DEPENDENT RNA AND DNA HELICASE ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG88577|UniProtKB=T1G739 T1G739 20216886 PTHR21575:SF12 PROTEIN HID1 PROTEIN HID1 cytoplasm#GO:0005737;Golgi cisterna#GO:0031985;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi apparatus subcompartment#GO:0098791;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;Golgi stack#GO:0005795;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG165588|UniProtKB=T1EX14 T1EX14 20201114 PTHR12205:SF0 CENTROMERE/KINETOCHORE PROTEIN ZW10 CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;negative regulation of sister chromatid segregation#GO:0033046;negative regulation of mitotic sister chromatid separation#GO:2000816;cellular localization#GO:0051641;negative regulation of biological process#GO:0048519;regulation of mitotic nuclear division#GO:0007088;signal transduction#GO:0007165;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;regulation of chromosome segregation#GO:0051983;mitotic cell cycle checkpoint signaling#GO:0007093;negative regulation of chromosome organization#GO:2001251;regulation of chromosome separation#GO:1905818;negative regulation of mitotic nuclear division#GO:0045839;transport#GO:0006810;cell cycle process#GO:0022402;regulation of cellular component organization#GO:0051128;negative regulation of cell cycle process#GO:0010948;negative regulation of nuclear division#GO:0051784;negative regulation of mitotic sister chromatid segregation#GO:0033048;mitotic cell cycle process#GO:1903047;regulation of biological process#GO:0050789;cell cycle checkpoint signaling#GO:0000075;negative regulation of mitotic cell cycle phase transition#GO:1901991;mitotic cell cycle#GO:0000278;establishment of localization#GO:0051234;negative regulation of organelle organization#GO:0010639;regulation of mitotic sister chromatid segregation#GO:0033047;intracellular signal transduction#GO:0035556;negative regulation of cellular component organization#GO:0051129;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;regulation of chromosome organization#GO:0033044;cellular response to stimulus#GO:0051716;regulation of mitotic sister chromatid separation#GO:0010965;regulation of nuclear division#GO:0051783;negative regulation of cell cycle#GO:0045786;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of organelle organization#GO:0033043;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;mitotic spindle assembly checkpoint signaling#GO:0007094;negative regulation of chromosome segregation#GO:0051985;regulation of cell cycle phase transition#GO:1901987;negative regulation of cell cycle phase transition#GO:1901988;vesicle-mediated transport#GO:0016192;negative regulation of mitotic cell cycle#GO:0045930;cell communication#GO:0007154;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;regulation of mitotic metaphase/anaphase transition#GO:0030071;regulation of cell cycle process#GO:0010564;localization#GO:0051179;response to stimulus#GO:0050896;negative regulation of chromosome separation#GO:1905819;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;regulation of sister chromatid segregation#GO:0033045;regulation of mitotic cell cycle#GO:0007346;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;kinetochore#GO:0000776;chromosome#GO:0005694;condensed chromosome, centromeric region#GO:0000779;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;chromosomal region#GO:0098687;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG115802|UniProtKB=T1EGA7 T1EGA7 20195609 PTHR10603:SF7 FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN FRAGILE X MESSENGER RIBONUCLEOPROTEIN 1 HOMOLOG RNA binding#GO:0003723;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159;mRNA 3'-UTR binding#GO:0003730 positive regulation of gene expression#GO:0010628;positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;regulation of mRNA stability#GO:0043488;regulation of mRNA catabolic process#GO:0061013;regulation of catabolic process#GO:0009894;macromolecule localization#GO:0033036;regulation of nitrogen compound metabolic process#GO:0051171;animal organ development#GO:0048513;positive regulation of cellular metabolic process#GO:0031325;transport#GO:0006810;developmental process#GO:0032502;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;RNA localization#GO:0006403;regulation of biological process#GO:0050789;organic substance transport#GO:0071702;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;RNA transport#GO:0050658;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;positive regulation of translation#GO:0045727;establishment of RNA localization#GO:0051236;positive regulation of cellular biosynthetic process#GO:0031328;regulation of cellular catabolic process#GO:0031329;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;mRNA transport#GO:0051028;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;localization#GO:0051179;regulation of primary metabolic process#GO:0080090;positive regulation of protein metabolic process#GO:0051247;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleobase-containing compound transport#GO:0015931;post-transcriptional regulation of gene expression#GO:0010608;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of metabolic process#GO:0019222;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytoplasmic stress granule#GO:0010494;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic ribonucleoprotein granule#GO:0036464 translation factor#PC00223 HELRO|EnsemblGenome=HelroG90361|UniProtKB=T1G7P7 T1G7P7 20217094 PTHR14187:SF46 ALPHA KINASE/ELONGATION FACTOR 2 KINASE HEAT SHOCK 70 KDA PROTEIN 12A HELRO|EnsemblGenome=HelroG107367|UniProtKB=T1EEA0 T1EEA0 20194902 PTHR24348:SF65 SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED SERINE_THREONINE-PROTEIN KINASE ULK3 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 microautophagy#GO:0016237;cellular component biogenesis#GO:0044085;regulation of catabolic process#GO:0009894;macroautophagy#GO:0016236;macromolecule modification#GO:0043412;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;autophagy of mitochondrion#GO:0000422;response to extracellular stimulus#GO:0009991;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;cellular component disassembly#GO:0022411;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;phosphorylation#GO:0016310;mitochondrion organization#GO:0007005;protein metabolic process#GO:0019538;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;macromolecule metabolic process#GO:0043170;regulation of autophagy#GO:0010506;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;cellular component organization#GO:0016043;response to nutrient levels#GO:0031667;regulation of cellular catabolic process#GO:0031329;cellular process#GO:0009987;organelle disassembly#GO:1903008;primary metabolic process#GO:0044238;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;response to external stimulus#GO:0009605;response to stimulus#GO:0050896;reticulophagy#GO:0061709;response to stress#GO:0006950;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;response to starvation#GO:0042594;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;autophagosome assembly#GO:0000045;piecemeal microautophagy of the nucleus#GO:0034727;autophagy#GO:0006914;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;phagophore assembly site#GO:0000407;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;vacuole#GO:0005773;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;autophagosome#GO:0005776;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG166598|UniProtKB=T1EYA3 T1EYA3 20201553 PTHR24217:SF0 PUTATIVE-RELATED PDZ DOMAIN-CONTAINING PROTEIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;actin binding#GO:0003779;binding#GO:0005488 positive regulation of organelle organization#GO:0010638;regulation of organelle organization#GO:0033043;regulation of actin filament organization#GO:0110053;regulation of cellular component organization#GO:0051128;positive regulation of cellular process#GO:0048522;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of cytoskeleton organization#GO:0051493;positive regulation of actin filament bundle assembly#GO:0032233;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament-based process#GO:0032970;positive regulation of cellular component biogenesis#GO:0044089;regulation of actin filament bundle assembly#GO:0032231;positive regulation of biological process#GO:0048518 supramolecular complex#GO:0099080;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;Z disc#GO:0030018;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;organelle#GO:0043226;contractile fiber#GO:0043292;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;sarcomere#GO:0030017;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;myofibril#GO:0030016;I band#GO:0031674 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG188494|UniProtKB=T1FQ20 T1FQ20 20210917 PTHR23025:SF3 TRIACYLGLYCEROL LIPASE HORMONE-SENSITIVE LIPASE hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824;triglyceride lipase activity#GO:0004806 lipid metabolic process#GO:0006629;triglyceride metabolic process#GO:0006641;neutral lipid catabolic process#GO:0046461;cellular metabolic process#GO:0044237;glycerolipid catabolic process#GO:0046503;triglyceride catabolic process#GO:0019433;lipid catabolic process#GO:0016042;cellular process#GO:0009987;acylglycerol metabolic process#GO:0006639;primary metabolic process#GO:0044238;acylglycerol catabolic process#GO:0046464;neutral lipid metabolic process#GO:0006638;glycerolipid metabolic process#GO:0046486;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 lipase#PC00143 Triacylglycerol metabolism#P02782>Triacylglycerol lipase#P03205 HELRO|EnsemblGenome=HelroG177646|UniProtKB=T1FC02 T1FC02 20206351 PTHR22765:SF416 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE GODZILLA transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG172932|UniProtKB=T1F656 T1F656 20204305 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164204|UniProtKB=T1EV34 T1EV34 20200434 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180458|UniProtKB=T1FFY1 T1FFY1 20207730 PTHR23117:SF18 GUANYLATE KINASE-RELATED LEUCINE-RICH REPEAT AND GUANYLATE KINASE DOMAIN-CONTAINING PROTEIN transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, phosphate group as acceptor#GO:0016776;catalytic activity#GO:0003824;kinase activity#GO:0016301 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 transferase#PC00220;kinase#PC00137;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG184200|UniProtKB=T1FKR2 T1FKR2 20209411 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG66198|UniProtKB=T1FYI4 T1FYI4 20213882 PTHR24044:SF506 NOTCH LIGAND FAMILY MEMBER NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2-LIKE protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG163754|UniProtKB=T1EUF1 T1EUF1 20200201 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG160756|UniProtKB=T1EQP2 T1EQP2 20198892 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172654|UniProtKB=T1F5Q6 T1F5Q6 20204155 PTHR45803:SF5 SOX100B SOX100B sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG102959|UniProtKB=T1EDD4 T1EDD4 20194586 PTHR10805:SF0 COATOMER SUBUNIT EPSILON COATOMER SUBUNIT EPSILON localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;intra-Golgi vesicle-mediated transport#GO:0006891;establishment of localization#GO:0051234;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;vesicle coat#GO:0030120;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;Golgi-associated vesicle membrane#GO:0030660;protein-containing complex#GO:0032991;COPI vesicle coat#GO:0030126;endomembrane system#GO:0012505;membrane coat#GO:0030117;coated vesicle membrane#GO:0030662;COPI-coated vesicle#GO:0030137;Golgi-associated vesicle#GO:0005798;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;coated membrane#GO:0048475;cytoplasmic vesicle membrane#GO:0030659 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG91957|UniProtKB=T1G8A7 T1G8A7 20217304 PTHR23113:SF368 GUANINE NUCLEOTIDE EXCHANGE FACTOR CELL DIVISION CONTROL PROTEIN 25 nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;Ras protein signal transduction#GO:0007265;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 PDGF signaling pathway#P00047>SOS#P01159;EGF receptor signaling pathway#P00018>SOS#P00558 HELRO|EnsemblGenome=HelroG175232|UniProtKB=T1F918 T1F918 20205317 PTHR15004:SF0 GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 HELRO|EnsemblGenome=HelroG187704|UniProtKB=T1FPC1 T1FPC1 20210668 PTHR12929:SF10 SOLUTE CARRIER FAMILY 52 RIBOFLAVIN TRANSPORTER transmembrane transporter activity#GO:0022857;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215 localization#GO:0051179;vitamin transport#GO:0051180;nitrogen compound transport#GO:0071705;organic substance transport#GO:0071702;establishment of localization#GO:0051234;organic anion transport#GO:0015711;transport#GO:0006810 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG169235|UniProtKB=T1F1M0 T1F1M0 20202720 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182868|UniProtKB=T1FIW3 T1FIW3 20208762 PTHR22763:SF162 RING ZINC FINGER PROTEIN TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG190959|UniProtKB=T1FSG6 T1FSG6 20211763 PTHR12480:SF19 ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD CUPIN-LIKE DOMAIN-CONTAINING PROTEIN sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;dioxygenase activity#GO:0051213;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491 positive regulation of gene expression#GO:0010628;positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;macromolecule modification#GO:0043412;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;protein modification process#GO:0036211;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;protein hydroxylation#GO:0018126;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;protein metabolic process#GO:0019538;positive regulation of biological process#GO:0048518;positive regulation of translation#GO:0045727;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;regulation of protein-containing complex disassembly#GO:0043244;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;primary metabolic process#GO:0044238;regulation of primary metabolic process#GO:0080090;positive regulation of protein metabolic process#GO:0051247;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;regulation of translation#GO:0006417;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG192589|UniProtKB=T1FU40 T1FU40 20212336 PTHR23163:SF0 RING FINGER PROTEIN-RELATED E3 UBIQUITIN-PROTEIN LIGASE BRE1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;chromatin#GO:0000785;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG175466|UniProtKB=T1F9A4 T1F9A4 20205403 PTHR12618:SF20 PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1 PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG153369|UniProtKB=T1EL53 T1EL53 20197303 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG72414|UniProtKB=T1G0Z7 T1G0Z7 20214745 PTHR48033:SF10 RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN RNA-BINDING PROTEIN SQUID nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG194513|UniProtKB=T1FW51 T1FW51 20213047 PTHR12425:SF5 SYNEMBRYN SYNEMBRYN nucleoside-triphosphatase regulator activity#GO:0060589;protein binding#GO:0005515;GTPase regulator activity#GO:0030695;binding#GO:0005488;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG89732|UniProtKB=T1G7G7 T1G7G7 20217014 PTHR12896:SF1 PAX6 NEIGHBOR PROTEIN PAXNEB ELONGATOR COMPLEX PROTEIN 4 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;tRNA wobble uridine modification#GO:0002098;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 elongator holoenzyme complex#GO:0033588;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;transcription elongation factor complex#GO:0008023;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG182558|UniProtKB=T1FIC5 T1FIC5 20208574 PTHR46462:SF3 UPSET, ISOFORM A UPSET, ISOFORM A HELRO|EnsemblGenome=HelroG117052|UniProtKB=T1EGJ7 T1EGJ7 20195699 PTHR24099:SF15 E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED E3 UBIQUITIN-PROTEIN LIGASE TRIM9 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG185807|UniProtKB=T1FNB4 T1FNB4 20210311 PTHR46447:SF1 INTERLEUKIN ENHANCER-BINDING FACTOR INTERLEUKIN ENHANCER-BINDING FACTOR 2 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;double-stranded RNA binding#GO:0003725;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 ribonucleoprotein complex#GO:1990904;catalytic step 2 spliceosome#GO:0071013;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG113444|UniProtKB=T1EFS5 T1EFS5 20195427 PTHR45922:SF1 CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2 CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;mRNA polyadenylation#GO:0006378;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;mRNA 3'-end processing#GO:0031124;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mRNA processing#GO:0006397;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;mRNA cleavage factor complex#GO:0005849;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG103356|UniProtKB=T1EDF8 T1EDF8 20194610 PTHR13659:SF5 AUTOSOMAL HIGHLY CONSERVED PROTEIN PROTEIN FAM8A1 HELRO|EnsemblGenome=HelroG184055|UniProtKB=T1FKH9 T1FKH9 20209328 PTHR34740:SF5 FINGER, C3HC4 TYPE, PUTATIVE-RELATED-RELATED POLYMERASE NUCLEOTIDYL TRANSFERASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157354|UniProtKB=T1EMA1 T1EMA1 20197701 PTHR24072:SF142 RHO FAMILY GTPASE RHOU, ISOFORM B GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;enzyme binding#GO:0019899;ribonucleoside triphosphate phosphatase activity#GO:0017111;kinase binding#GO:0019900;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817;protein kinase binding#GO:0019901;anion binding#GO:0043168;ion binding#GO:0043167 establishment or maintenance of cell polarity#GO:0007163;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;small GTPase-mediated signal transduction#GO:0007264;transport#GO:0006810;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cell communication#GO:0007154;cellular process#GO:0009987;Rho protein signal transduction#GO:0007266;localization#GO:0051179;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;establishment of cell polarity#GO:0030010;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;intracellular signal transduction#GO:0035556;import into cell#GO:0098657;signaling#GO:0023052 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG186038|UniProtKB=T1FNK8 T1FNK8 20210405 PTHR35836:SF1 VCBS REPEAT-CONTAINING PROTEIN VCBS REPEAT-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163064|UniProtKB=T1ETM1 T1ETM1 20199921 PTHR34587:SF2 VWFA DOMAIN-CONTAINING PROTEIN G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG114723|UniProtKB=T1EG43 T1EG43 20195545 PTHR11556:SF1 FRUCTOSE-1,6-BISPHOSPHATASE-RELATED FRUCTOSE-BISPHOSPHATASE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;sugar-phosphatase activity#GO:0050308;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 monosaccharide metabolic process#GO:0005996;carbohydrate biosynthetic process#GO:0016051;carbohydrate derivative metabolic process#GO:1901135;cellular metabolic process#GO:0044237;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;glucose metabolic process#GO:0006006;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;hexose biosynthetic process#GO:0019319;oligosaccharide biosynthetic process#GO:0009312;organophosphate metabolic process#GO:0019637;small molecule biosynthetic process#GO:0044283;hexose metabolic process#GO:0019318;carbohydrate metabolic process#GO:0005975;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 carbohydrate phosphatase#PC00066;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG173765|UniProtKB=T1F773 T1F773 20204672 PTHR11177:SF317 CHITINASE CHITINASE 12-RELATED glycosidase#PC00110;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG169185|UniProtKB=T1F1J5 T1F1J5 20202695 PTHR22748:SF6 AP ENDONUCLEASE DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE hydrolase activity, acting on ester bonds#GO:0016788;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;3'-5'-DNA exonuclease activity#GO:0008296;nuclease activity#GO:0004518;DNA exonuclease activity#GO:0004529;catalytic activity#GO:0003824;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097;phosphoric diester hydrolase activity#GO:0008081;exonuclease activity#GO:0004527;3'-5' exonuclease activity#GO:0008408;phosphoric ester hydrolase activity#GO:0042578 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;base-excision repair#GO:0006284;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 HELRO|EnsemblGenome=HelroG190283|UniProtKB=T1FRV0 T1FRV0 20211547 PTHR13524:SF2 MYOTUBULARIN-RELATED MYOTUBULARIN-RELATED PROTEIN 14 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG79991|UniProtKB=T1G3W1 T1G3W1 20215759 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG78261|UniProtKB=T1G3A0 T1G3A0 20215548 PTHR46259:SF1 ZINC FINGER CCHC-TYPE AND RNA-BINDING MOTIF-CONTAINING PROTEIN 1 ZINC FINGER CCHC-TYPE AND RNA-BINDING MOTIF-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG185311|UniProtKB=T1FMN3 T1FMN3 20210082 PTHR12000:SF42 HEMOGLOBINASE FAMILY MEMBER LEGUMAIN cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197 macromolecule catabolic process#GO:0009057;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG163956|UniProtKB=T1EUN6 T1EUN6 20200286 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED FMRFAMIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG155984|UniProtKB=T1ELQ4 T1ELQ4 20197504 PTHR11599:SF4 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT BETA hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;proteasome complex#GO:0000502;membrane-bounded organelle#GO:0043227;endopeptidase complex#GO:1905369;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG75102|UniProtKB=T1G207 T1G207 20215105 PTHR18934:SF264 ATP-DEPENDENT RNA HELICASE ATP-DEPENDENT RNA HELICASE DHX29 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640 cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG165525|UniProtKB=T1EWY9 T1EWY9 20201089 PTHR13464:SF0 TRANSCRIPTIONAL REGULATOR PROTEIN HCNGP SAP30-BINDING PROTEIN membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG169116|UniProtKB=T1F1F2 T1F1F2 20202652 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN SI:DKEY-17M8.2 HELRO|EnsemblGenome=HelroG173304|UniProtKB=T1F6N5 T1F6N5 20204484 PTHR45721:SF12 LAMIN DM0-RELATED INTERMEDIATE FILAMENT PROTEIN IFA-1 structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;nuclear migration#GO:0007097;cellular localization#GO:0051641;negative regulation of biological process#GO:0048519;protein-DNA complex organization#GO:0071824;organelle localization#GO:0051640;macromolecule localization#GO:0033036;membrane organization#GO:0061024;transport#GO:0006810;protein localization to nucleus#GO:0034504;nucleus organization#GO:0006997;endomembrane system organization#GO:0010256;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;protein localization to organelle#GO:0033365;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;establishment of organelle localization#GO:0051656;negative regulation of cellular process#GO:0048523;localization within membrane#GO:0051668;negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;cellular process#GO:0009987;negative regulation of gene expression, epigenetic#GO:0045814;epigenetic regulation of gene expression#GO:0040029;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular macromolecule localization#GO:0070727;heterochromatin organization#GO:0070828;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;chromatin organization#GO:0006325;intracellular transport#GO:0046907;nuclear envelope organization#GO:0006998;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323;protein-containing complex localization#GO:0031503 membrane-enclosed lumen#GO:0031974;envelope#GO:0031975;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;nuclear periphery#GO:0034399;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981 HELRO|EnsemblGenome=HelroG165589|UniProtKB=T1EX15 T1EX15 20201115 PTHR23350:SF4 PEROXISOME ASSEMBLY PROTEIN 10 PEROXISOME BIOGENESIS FACTOR 2 chaperone#PC00072 HELRO|EnsemblGenome=HelroG84957|UniProtKB=T1G5Q9 T1G5Q9 20216406 PTHR23113:SF363 GUANINE NUCLEOTIDE EXCHANGE FACTOR PROTEIN SON OF SEVENLESS nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;Ras protein signal transduction#GO:0007265;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 FGF signaling pathway#P00021>SOS#P00641;Angiogenesis#P00005>SOS-1#P00193;Integrin signalling pathway#P00034>SOS#P00920;PDGF signaling pathway#P00047>SOS#P01159;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>SOS#P00883;EGF receptor signaling pathway#P00018>SOS#P00558;Ras Pathway#P04393>SOS#P04552 HELRO|EnsemblGenome=HelroG96557|UniProtKB=T1G9C9 T1G9C9 20217676 PTHR11920:SF494 GUANYLYL CYCLASE ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2 adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 Gonadotropin-releasing hormone receptor pathway#P06664>Npr2#P06796;Endothelin signaling pathway#P00019>Guanylate cyclase#P00581 HELRO|EnsemblGenome=HelroG68919|UniProtKB=T1FZL5 T1FZL5 20214263 PTHR24241:SF83 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTOR 150-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;binding#GO:0005488;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888;amide binding#GO:0033218 response to organic substance#GO:0010033;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;response to hormone#GO:0009725;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG134299|UniProtKB=T1EI41 T1EI41 20196241 PTHR11267:SF190 T-BOX PROTEIN-RELATED T-BOX TRANSCRIPTION FACTOR TBX20 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cell fate commitment#GO:0045165;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;cell fate specification#GO:0001708;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HELRO|EnsemblGenome=HelroG63833|UniProtKB=T1FXL1 T1FXL1 20213559 PTHR24343:SF345 SERINE/THREONINE KINASE TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 4 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG113661|UniProtKB=T1EFU8 T1EFU8 20195450 PTHR22957:SF168 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC DOMAIN-CONTAINING PROTEIN KINASE-LIKE PROTEIN nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;activation of GTPase activity#GO:0090630;biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG182946|UniProtKB=T1FIY6 T1FIY6 20208785 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED single-stranded RNA binding#GO:0003727;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;poly(A) binding#GO:0008143;binding#GO:0005488;organic cyclic compound binding#GO:0097159 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG194751|UniProtKB=T1FWD3 T1FWD3 20213128 PTHR28559:SF1 DNA REPAIR PROTEIN XRCC4 DNA REPAIR PROTEIN XRCC4 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;double-strand break repair#GO:0006302;positive regulation of catalytic activity#GO:0043085;macromolecule metabolic process#GO:0043170;positive regulation of molecular function#GO:0044093;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;regulation of catalytic activity#GO:0050790;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;double-strand break repair via nonhomologous end joining#GO:0006303;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;response to stress#GO:0006950;regulation of molecular function#GO:0065009;nitrogen compound metabolic process#GO:0006807;response to radiation#GO:0009314;biological regulation#GO:0065007;response to abiotic stimulus#GO:0009628;cellular response to stress#GO:0033554;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;metabolic process#GO:0008152 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG64273|UniProtKB=T1FXS2 T1FXS2 20213620 PTHR24031:SF594 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX52-RELATED cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;protein-containing complex#GO:0032991;90S preribosome#GO:0030686 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG105715|UniProtKB=T1EDX1 T1EDX1 20194773 PTHR16119:SF17 TRANSMEMBRANE PROTEIN 144 TRANSMEMBRANE PROTEIN 144 HELRO|EnsemblGenome=HelroG172613|UniProtKB=T1F5M6 T1F5M6 20204125 PTHR23279:SF36 DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED DEFECTIVE PROBOSCIS EXTENSION RESPONSE 9, ISOFORM A cellular component organization or biogenesis#GO:0071840;synapse organization#GO:0050808;cellular component organization#GO:0016043;cellular process#GO:0009987;cell junction organization#GO:0034330 cell leading edge#GO:0031252;neuron projection#GO:0043005;leading edge membrane#GO:0031256;plasma membrane region#GO:0098590;cell projection membrane#GO:0031253;cell projection#GO:0042995;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG194120|UniProtKB=T1FVQ1 T1FVQ1 20212897 PTHR10693:SF20 RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN AT27578P nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;cytosol#GO:0005829;protein-containing complex#GO:0032991;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG181863|UniProtKB=T1FHE7 T1FHE7 20208246 PTHR46458:SF5 BLR2807 PROTEIN GLOBIN FAMILY PROFILE DOMAIN-CONTAINING PROTEIN transporter#PC00227 HELRO|EnsemblGenome=HelroG159716|UniProtKB=T1EPC3 T1EPC3 20198423 PTHR33332:SF48 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173929|UniProtKB=T1F7E0 T1F7E0 20204739 PTHR33395:SF21 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED PERICARDIN heart morphogenesis#GO:0003007;system development#GO:0048731;heart development#GO:0007507;circulatory system development#GO:0072359;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;animal organ development#GO:0048513;multicellular organism development#GO:0007275;developmental process#GO:0032502;animal organ morphogenesis#GO:0009887;multicellular organismal process#GO:0032501;cell adhesion#GO:0007155;cellular process#GO:0009987;post-embryonic development#GO:0009791 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG180213|UniProtKB=T1FFK9 T1FFK9 20207608 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG99725|UniProtKB=T1G9U9 T1G9U9 20217845 PTHR10555:SF170 SORTING NEXIN FI18122P1 lipid binding#GO:0008289;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;binding#GO:0005488 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG179029|UniProtKB=T1FE27 T1FE27 20207076 PTHR11339:SF402 EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED VWFD DOMAIN-CONTAINING PROTEIN extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG117043|UniProtKB=T1EGJ6 T1EGJ6 20195698 PTHR11963:SF23 LEUCINE AMINOPEPTIDASE-RELATED CYTOSOL AMINOPEPTIDASE hydrolase activity#GO:0016787;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG191658|UniProtKB=T1FT67 T1FT67 20212014 PTHR12865:SF1 PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301;lipid kinase activity#GO:0001727 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;Golgi organization#GO:0007030;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycerolipid biosynthetic process#GO:0045017;endomembrane system organization#GO:0010256;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;cellular component organization or biogenesis#GO:0071840;endosome organization#GO:0007032;glycerolipid metabolic process#GO:0046486;organelle organization#GO:0006996;glycerophospholipid biosynthetic process#GO:0046474;vesicle organization#GO:0016050;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 trans-Golgi network#GO:0005802;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;organelle subcompartment#GO:0031984;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791;plasma membrane#GO:0005886 kinase#PC00137 HELRO|EnsemblGenome=HelroG175194|UniProtKB=T1F8Z6 T1F8Z6 20205295 PTHR23285:SF7 RING FINGER AND KH DOMAIN CONTAINING PROTEIN 1 LD09246P1 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG169712|UniProtKB=T1F294 T1F294 20202944 PTHR13270:SF14 PROTEIN C20ORF116-RELATED SEX DETERMINATION AND DOSAGE COMPENSATION PROTEIN SDC-2 HELRO|EnsemblGenome=HelroG156862|UniProtKB=T1EM21 T1EM21 20197621 PTHR13042:SF0 UBIQUITIN-LIKE PROTEIN 5 UBIQUITIN-LIKE PROTEIN 5 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;protein metabolic process#GO:0019538;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG127015|UniProtKB=T1EHC1 T1EHC1 20195971 PTHR10252:SF5 HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED DR1-ASSOCIATED COREPRESSOR sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;core promoter sequence-specific DNA binding#GO:0001046;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG107813|UniProtKB=T1EEC9 T1EEC9 20194931 PTHR45780:SF2 ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;glycerophospholipid metabolic process#GO:0006650;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;primary metabolic process#GO:0044238;glycerolipid metabolic process#GO:0046486;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 nucleotidyltransferase#PC00174 HELRO|EnsemblGenome=HelroG165477|UniProtKB=T1EWV7 T1EWV7 20201057 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG90701|UniProtKB=T1G7U6 T1G7U6 20217143 PTHR22870:SF446 REGULATOR OF CHROMOSOME CONDENSATION REGULATOR OF CHROMOSOME CONDENSATION DOMAIN-CONTAINING PROTEIN guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG76754|UniProtKB=T1G2P0 T1G2P0 20215338 PTHR21245:SF15 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN RRM DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG172965|UniProtKB=T1F681 T1F681 20204330 PTHR24104:SF57 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED BEE-MILK PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG163957|UniProtKB=T1EUN7 T1EUN7 20200287 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG110124|UniProtKB=T1EEZ5 T1EEZ5 20195147 PTHR24248:SF185 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR DOPAMINE RECEPTOR 2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;regulation of cell communication#GO:0010646;cellular response to stimulus#GO:0051716;regulation of MAPK cascade#GO:0043408;signal transduction#GO:0007165;positive regulation of signal transduction#GO:0009967;regulation of signaling#GO:0023051;cell communication#GO:0007154;cellular process#GO:0009987;regulation of intracellular signal transduction#GO:1902531;positive regulation of MAPK cascade#GO:0043410;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;positive regulation of response to stimulus#GO:0048584;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;positive regulation of cell communication#GO:0010647;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HELRO|EnsemblGenome=HelroG70277|UniProtKB=T1G041 T1G041 20214439 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG87612|UniProtKB=T1G6T0 T1G6T0 20216777 PTHR11548:SF2 THYMIDYLATE SYNTHASE 1 THYMIDYLATE SYNTHASE methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;pyrimidine nucleotide metabolic process#GO:0006220;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;pyrimidine-containing compound metabolic process#GO:0072527;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;nucleoside monophosphate metabolic process#GO:0009123;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 Formyltetrahydrofolate biosynthesis#P02743>Thymidylate synthase#P02954;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>Thymidylate synthase#P02913;Formyltetrahydrofolate biosynthesis#P02743>Dihydrofolate reductase#P02957;Tetrahydrofolate biosynthesis#P02742>Dihydrofolate reductase#P02948;Tetrahydrofolate biosynthesis#P02742>Dihydrofolate synthase#P02943 HELRO|EnsemblGenome=HelroG194214|UniProtKB=T1FVT4 T1FVT4 20212930 PTHR11595:SF21 EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER ELONGATION FACTOR 1-BETA nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;translational elongation#GO:0006414;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 translation elongation factor#PC00222;translational protein#PC00263 HELRO|EnsemblGenome=HelroG173095|UniProtKB=T1F6C2 T1F6C2 20204371 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG153393|UniProtKB=T1EL67 T1EL67 20197317 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG64912|UniProtKB=T1FY11 T1FY11 20213709 PTHR10966:SF0 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2 protein binding#GO:0005515;transcription factor binding#GO:0008134;binding#GO:0005488;TBP-class protein binding#GO:0017025 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;RNA metabolic process#GO:0016070;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;RNA polymerase II preinitiation complex assembly#GO:0051123;transcription initiation at RNA polymerase II promoter#GO:0006367;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;DNA-directed RNA polymerase complex#GO:0000428;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nucleoplasm#GO:0005654;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;transcription regulator complex#GO:0005667;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 general transcription factor#PC00259 General transcription regulation#P00023>TFIIA complex#P00662;Transcription regulation by bZIP transcription factor#P00055>TFIIA complex#P01390 HELRO|EnsemblGenome=HelroG104956|UniProtKB=T1EDP4 T1EDP4 20194696 PTHR48099:SF5 C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular modified amino acid metabolic process#GO:0006575;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;folic acid-containing compound metabolic process#GO:0006760;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262 Formyltetrahydrofolate biosynthesis#P02743>Methylene tetrahydrofolate dehydrogenase#P02952 HELRO|EnsemblGenome=HelroG186652|UniProtKB=T1FP19 T1FP19 20210566 PTHR11588:SF13 TUBULIN TUBULIN EPSILON CHAIN carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;structural molecule activity#GO:0005198;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;structural constituent of cytoskeleton#GO:0005200 cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;microtubule-based process#GO:0007017;organelle organization#GO:0006996;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;cell cycle#GO:0007049;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 tubulin#PC00228;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG186037|UniProtKB=T1FNK7 T1FNK7 20210404 PTHR10656:SF70 CELL FATE DETERMINING PROTEIN MAB21-RELATED PROTEIN MAB-21-RELATED transferase#PC00220;nucleotidyltransferase#PC00174;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG182250|UniProtKB=T1FI00 T1FI00 20208449 PTHR15439:SF22 RETINOBLASTOMA-BINDING PROTEIN 6 C3H1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG175078|UniProtKB=T1F8T7 T1F8T7 20205236 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG166386|UniProtKB=T1EY27 T1EY27 20201477 PTHR12107:SF0 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT STARGAZIN (MAMMALIAN CALCIUM CHANNEL) HOMOLOG calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;voltage-gated channel activity#GO:0022832;molecular function regulator activity#GO:0098772;transporter regulator activity#GO:0141108;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;channel regulator activity#GO:0016247;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;inorganic cation transmembrane transporter activity#GO:0022890 cellular localization#GO:0051641;macromolecule localization#GO:0033036;receptor internalization#GO:0031623;system process#GO:0003008;transport#GO:0006810;regulation of signaling#GO:0023051;nitrogen compound transport#GO:0071705;regulation of localization#GO:0032879;endosome to lysosome transport#GO:0008333;lysosomal transport#GO:0007041;establishment of protein localization#GO:0045184;regulation of biological process#GO:0050789;organic substance transport#GO:0071702;regulation of transport#GO:0051049;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;regulation of molecular function#GO:0065009;regulation of signal transduction#GO:0009966;receptor-mediated endocytosis#GO:0006898;regulation of monoatomic ion transmembrane transporter activity#GO:0032412;regulation of transmembrane transporter activity#GO:0022898;protein localization to organelle#GO:0033365;regulation of transporter activity#GO:0032409;positive regulation of signaling#GO:0023056;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;positive regulation of biological process#GO:0048518;localization within membrane#GO:0051668;regulation of cell communication#GO:0010646;establishment of protein localization to vacuole#GO:0072666;regulation of transmembrane transport#GO:0034762;vacuolar transport#GO:0007034;endocytosis#GO:0006897;protein localization to vacuole#GO:0072665;vesicle-mediated transport#GO:0016192;establishment of protein localization to organelle#GO:0072594;nervous system process#GO:0050877;cell communication#GO:0007154;cellular process#GO:0009987;regulation of synaptic transmission, glutamatergic#GO:0051966;protein localization#GO:0008104;positive regulation of cellular process#GO:0048522;localization#GO:0051179;regulation of response to stimulus#GO:0048583;protein localization to lysosome#GO:0061462;cellular macromolecule localization#GO:0070727;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;positive regulation of cell communication#GO:0010647;protein transport#GO:0015031;biological regulation#GO:0065007;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;regulation of trans-synaptic signaling#GO:0099177;multicellular organismal process#GO:0032501;intracellular transport#GO:0046907;positive regulation of synaptic transmission#GO:0050806;import into cell#GO:0098657;protein-containing complex localization#GO:0031503 membrane protein complex#GO:0098796;synapse#GO:0045202;postsynaptic specialization#GO:0099572;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;plasma membrane signaling receptor complex#GO:0098802;transporter complex#GO:1990351;plasma membrane protein complex#GO:0098797;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;neuron to neuron synapse#GO:0098984;membrane#GO:0016020;synaptic membrane#GO:0097060;asymmetric synapse#GO:0032279;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;transmembrane transporter complex#GO:1902495;postsynaptic density membrane#GO:0098839;postsynaptic specialization membrane#GO:0099634;plasma membrane region#GO:0098590;postsynapse#GO:0098794;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG188809|UniProtKB=T1FQD9 T1FQD9 20211036 PTHR44176:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 25 DNAJ HOMOLOG SUBFAMILY C MEMBER 25 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein folding#GO:0006457;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG96497|UniProtKB=T1G9C6 T1G9C6 20217673 PTHR12454:SF11 TRIMERIC INTRACELLULAR CATION CHANNEL GH25683P ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG158620|UniProtKB=T1EN06 T1EN06 20197956 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG130363|UniProtKB=T1EHT7 T1EHT7 20196137 PTHR13808:SF1 CBP/P300-RELATED HISTONE ACETYLTRANSFERASE histone modifying activity#GO:0140993;nucleic acid binding#GO:0003676;acyltransferase activity#GO:0016746;peptide N-acetyltransferase activity#GO:0034212;binding#GO:0005488;catalytic activity#GO:0003824;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;N-acyltransferase activity#GO:0016410;histone acetyltransferase activity#GO:0004402;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;molecular adaptor activity#GO:0060090;N-acetyltransferase activity#GO:0008080;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;chromatin DNA binding#GO:0031490;transferase activity#GO:0016740;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;protein-containing complex binding#GO:0044877;catalytic activity, acting on a protein#GO:0140096 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of RNA metabolic process#GO:0051254;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;chromatin#GO:0000785;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;chromosome#GO:0005694 histone modifying enzyme#PC00261 DPP signaling pathway#P06213>NEJ#P06284;TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282;SCW signaling pathway#P06216>NEJ#P06328;GBB signaling pathway#P06214>NEJ#P06295;BMP/activin signaling pathway-drosophila#P06211>NEJ#P06246;p53 pathway#P00059>CBP#P04623;Wnt signaling pathway#P00057>CBP#P01448;Transcription regulation by bZIP transcription factor#P00055>CBP/P300#P01387;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CREB#P00713;DPP-SCW signaling pathway#P06212>NEJ#P06260;Huntington disease#P00029>CBP#P00777 HELRO|EnsemblGenome=HelroG155708|UniProtKB=T1ELL2 T1ELL2 20197462 PTHR45820:SF4 FI23527P1 ZINC TRANSPORTER 63C, ISOFORM F inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075 inorganic ion homeostasis#GO:0098771;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;inorganic ion transmembrane transport#GO:0098660;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation transport#GO:0006812;transition metal ion transport#GO:0000041;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG94403|UniProtKB=T1G908 T1G908 20217555 PTHR21705:SF11 RAI16 PROTEIN-RELATED FHIP FAMILY PROTEIN CG3558 HELRO|EnsemblGenome=HelroG107062|UniProtKB=T1EE70 T1EE70 20194872 PTHR23077:SF27 AAA-FAMILY ATPASE ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A pyrophosphatase activity#GO:0016462;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG83363|UniProtKB=T1G546 T1G546 20216194 PTHR46090:SF2 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 13B ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 13B HELRO|EnsemblGenome=HelroG165006|UniProtKB=T1EW41 T1EW41 20200791 PTHR45749:SF21 FAMILY NOT NAMED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG155589|UniProtKB=T1ELJ3 T1ELJ3 20197443 PTHR23118:SF42 ATP-CITRATE SYNTHASE ATP-CITRATE SYNTHASE transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;sulfur compound metabolic process#GO:0006790;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;carboxylic acid biosynthetic process#GO:0046394;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;amide metabolic process#GO:0043603;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;fatty acid biosynthetic process#GO:0006633;metabolic process#GO:0008152;organic acid biosynthetic process#GO:0016053;heterocycle metabolic process#GO:0046483;oxoacid metabolic process#GO:0043436;monocarboxylic acid biosynthetic process#GO:0072330;acyl-CoA metabolic process#GO:0006637;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;amide biosynthetic process#GO:0043604;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;fatty acid metabolic process#GO:0006631;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;small molecule biosynthetic process#GO:0044283;nucleotide metabolic process#GO:0009117;cellular lipid metabolic process#GO:0044255;carboxylic acid metabolic process#GO:0019752;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 Pyruvate metabolism#P02772>Citrate Lyase#P03137 HELRO|EnsemblGenome=HelroG174974|UniProtKB=T1F8N8 T1F8N8 20205187 PTHR33137:SF48 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15A-RELATED E3 UBIQUITIN-PROTEIN LIGASE IRF2BPL-RELATED general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG178644|UniProtKB=T1FDH7 T1FDH7 20206876 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG115562|UniProtKB=T1EG93 T1EG93 20195595 PTHR45700:SF3 UBIQUITIN-PROTEIN LIGASE E3C UBIQUITIN-PROTEIN LIGASE E3B transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E3#P01490 HELRO|EnsemblGenome=HelroG190104|UniProtKB=T1FRP4 T1FRP4 20211491 PTHR15491:SF9 FAMILY NOT NAMED CIP1-INTERACTING ZINC FINGER PROTEIN HELRO|EnsemblGenome=HelroG68329|UniProtKB=T1FZD1 T1FZD1 20214179 PTHR11753:SF5 ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY AP COMPLEX SUBUNIT SIGMA localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;cellular process#GO:0009987;transport#GO:0006810 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG155967|UniProtKB=T1ELQ1 T1ELQ1 20197501 PTHR11588:SF504 TUBULIN TUBULIN BETA-1 CHAIN-RELATED carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;structural molecule activity#GO:0005198;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;structural constituent of cytoskeleton#GO:0005200 cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;microtubule-based process#GO:0007017;organelle organization#GO:0006996;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;cell cycle#GO:0007049;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 tubulin#PC00228;microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Microtubule#P00780;Huntington disease#P00029>beta-Tubulin#P00790;Cytoskeletal regulation by Rho GTPase#P00016>tubulin#P00526 HELRO|EnsemblGenome=HelroG85197|UniProtKB=T1G5U2 T1G5U2 20216439 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG194228|UniProtKB=T1FVU2 T1FVU2 20212938 PTHR24041:SF32 MUCIN ANKYRIN REPEAT-CONTAINING PROTEIN cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG191974|UniProtKB=T1FTH1 T1FTH1 20212118 PTHR24347:SF444 SERINE/THREONINE-PROTEIN KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG160520|UniProtKB=T1EQC7 T1EQC7 20198777 PTHR24351:SF110 RIBOSOMAL PROTEIN S6 KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;nitrogen compound metabolic process#GO:0006807;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 Interleukin signaling pathway#P00036>p90RSK#P00964;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>P90 RSK#P00888;PDGF signaling pathway#P00047>p90RSK#P01142 HELRO|EnsemblGenome=HelroG157527|UniProtKB=T1EMC5 T1EMC5 20197725 PTHR43294:SF13 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium ion transmembrane transporter activity#GO:0015079;sodium ion transmembrane transporter activity#GO:0015081;P-type ion transporter activity#GO:0015662;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075 inorganic ion homeostasis#GO:0098771;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;proton transmembrane transport#GO:1902600;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;sodium ion homeostasis#GO:0055078;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;import into cell#GO:0098657;monoatomic cation transmembrane transport#GO:0098655;export from cell#GO:0140352;sodium ion transmembrane transport#GO:0035725;potassium ion import across plasma membrane#GO:1990573;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG91681|UniProtKB=T1G878 T1G878 20217275 PTHR11834:SF0 TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED PROTEIN SCALLOPED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG164928|UniProtKB=T1EVZ4 T1EVZ4 20200744 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG119140|UniProtKB=T1EGM5 T1EGM5 20195725 PTHR24416:SF539 TYROSINE-PROTEIN KINASE RECEPTOR RECEPTOR PROTEIN-TYROSINE KINASE signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG175929|UniProtKB=T1F9X0 T1F9X0 20205619 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171347|UniProtKB=T1F458 T1F458 20203607 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG81315|UniProtKB=T1G4C8 T1G4C8 20215926 PTHR11347:SF226 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE DUAL SPECIFICITY CALCIUM_CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric diester hydrolase activity#GO:0008081;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;cAMP-mediated signaling#GO:0019933;signaling#GO:0023052;cyclic-nucleotide-mediated signaling#GO:0019935 phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG143868|UniProtKB=T1EJC7 T1EJC7 20196677 PTHR46473:SF10 GH08155P LD45603P-RELATED HELRO|EnsemblGenome=HelroG184821|UniProtKB=T1FM18 T1FM18 20209867 PTHR10218:SF329 GTP-BINDING PROTEIN ALPHA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN G(Q) SUBUNIT ALPHA GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;ribonucleoside triphosphate phosphatase activity#GO:0017111;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 regulation of biological process#GO:0050789;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;side of membrane#GO:0098552;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;extrinsic component of membrane#GO:0019898 heterotrimeric G-protein#PC00117;G-protein#PC00020 Endothelin signaling pathway#P00019>Gq#P00586;Metabotropic glutamate receptor group I pathway#P00041>G-Protein#P01057;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>Gqalpha#P05927;Gonadotropin-releasing hormone receptor pathway#P06664>gnaq/11#P06841;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Galphaq#P00826;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Gqalpha#P00732;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;Wnt signaling pathway#P00057>Galpha#P01451;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Galphai/q#P00873;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;PI3 kinase pathway#P00048>Galpha#P01199 HELRO|EnsemblGenome=HelroG192026|UniProtKB=T1FTI5 T1FTI5 20212132 PTHR48041:SF116 ABC TRANSPORTER G FAMILY MEMBER 28 PROTEIN BROWN transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG191935|UniProtKB=T1FTF2 T1FTF2 20212099 PTHR15576:SF1 RIBITOL-5-PHOSPHATE XYLOSYLTRANSFERASE 1 RIBITOL-5-PHOSPHATE XYLOSYLTRANSFERASE 1 UDP-xylosyltransferase activity#GO:0035252;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;xylosyltransferase activity#GO:0042285;pentosyltransferase activity#GO:0016763;catalytic activity#GO:0003824;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;protein O-linked mannosylation#GO:0035269;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein mannosylation#GO:0035268;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085;mannosylation#GO:0097502 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG65278|UniProtKB=T1FY53 T1FY53 20213751 PTHR12835:SF5 BIOTIN PROTEIN LIGASE BIOTIN--PROTEIN LIGASE ligase activity#GO:0016874;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG193703|UniProtKB=T1FVA1 T1FVA1 20212747 PTHR22948:SF76 TUDOR DOMAIN CONTAINING PROTEIN FI20010P1-RELATED scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG164357|UniProtKB=T1EVB3 T1EVB3 20200513 PTHR16501:SF6 TRANSPORT AND GOLGI ORGANIZATION PROTEIN 11 TRANSPORT AND GOLGI ORGANIZATION PROTEIN 11 HELRO|EnsemblGenome=HelroG65501|UniProtKB=T1FY89 T1FY89 20213787 PTHR10527:SF3 IMPORTIN BETA FI21453P1-RELATED signal sequence binding#GO:0005048;binding#GO:0005488;amide binding#GO:0033218;peptide binding#GO:0042277 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;protein import into nucleus#GO:0006606;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;protein localization to organelle#GO:0033365;intracellular transport#GO:0046907;nuclear transport#GO:0051169;import into nucleus#GO:0051170 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG166358|UniProtKB=T1EY19 T1EY19 20201469 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG169862|UniProtKB=T1F2D9 T1F2D9 20202989 PTHR31395:SF23 SHISA GEO05642P1 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG124660|UniProtKB=T1EH24 T1EH24 20195874 PTHR31501:SF7 CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1 CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG69804|UniProtKB=T1FZY7 T1FZY7 20214385 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG65325|UniProtKB=T1FY63 T1FY63 20213761 PTHR21451:SF0 HISTONE H3 METHYLTRANSFERASE HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC N-methyltransferase activity#GO:0008170;histone modifying activity#GO:0140993;transferase activity#GO:0016740;catalytic activity#GO:0003824;histone methyltransferase activity#GO:0042054;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;protein-lysine N-methyltransferase activity#GO:0016279;catalytic activity, acting on a protein#GO:0140096;lysine N-methyltransferase activity#GO:0016278;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein methyltransferase activity#GO:0008276 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;signal transduction#GO:0007165;negative regulation of biological process#GO:0048519;DNA damage checkpoint signaling#GO:0000077;negative regulation of cell cycle process#GO:0010948;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;cell cycle checkpoint signaling#GO:0000075;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;regulation of molecular function#GO:0065009;nitrogen compound metabolic process#GO:0006807;signal transduction in response to DNA damage#GO:0042770;intracellular signal transduction#GO:0035556;signaling#GO:0023052;negative regulation of cellular process#GO:0048523;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;negative regulation of cell cycle#GO:0045786;macromolecule metabolic process#GO:0043170;negative regulation of cell cycle phase transition#GO:1901988;regulation of cell cycle phase transition#GO:1901987;cellular metabolic process#GO:0044237;cell communication#GO:0007154;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;regulation of cell cycle process#GO:0010564;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;DNA integrity checkpoint signaling#GO:0031570;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG105275|UniProtKB=T1EDS7 T1EDS7 20194729 PTHR10590:SF4 SODIUM/NUCLEOSIDE COTRANSPORTER SOLUTE CARRIER FAMILY 28 MEMBER 3 carbohydrate derivative transmembrane transporter activity#GO:1901505;secondary active transmembrane transporter activity#GO:0015291;nucleoside transmembrane transporter activity#GO:0005337;transmembrane transporter activity#GO:0022857;symporter activity#GO:0015293;nucleobase-containing compound transmembrane transporter activity#GO:0015932;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215 localization#GO:0051179;organic substance transport#GO:0071702;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;nucleobase-containing compound transport#GO:0015931;transport#GO:0006810;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG161503|UniProtKB=T1ERK3 T1ERK3 20199203 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG86622|UniProtKB=T1G6E4 T1G6E4 20216641 PTHR11675:SF43 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 1 transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG176661|UniProtKB=T1FAS0 T1FAS0 20205919 PTHR44500:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 12 DNAJ HOMOLOG SUBFAMILY C MEMBER 12 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG98742|UniProtKB=T1G9P5 T1G9P5 20217791 PTHR19134:SF531 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE LAR hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG66432|UniProtKB=T1FYL1 T1FYL1 20213909 PTHR28314:SF1 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29 molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein binding#GO:0005515;transcription factor binding#GO:0008134;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG161019|UniProtKB=T1ER06 T1ER06 20199006 PTHR44054:SF3 SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG-LIKE PDZ DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG109167|UniProtKB=T1EEQ8 T1EEQ8 20195060 PTHR13847:SF287 SARCOSINE DEHYDROGENASE-RELATED FAD-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG194786|UniProtKB=T1FWE8 T1FWE8 20213143 PTHR13132:SF29 ALPHA- 1,6 -FUCOSYLTRANSFERASE ALPHA-(1,6)-FUCOSYLTRANSFERASE transferase activity#GO:0016740;fucosyltransferase activity#GO:0008417;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein glycosylation#GO:0006486;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;protein metabolic process#GO:0019538;glycosylation#GO:0070085;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 glycosyltransferase#PC00111 Notch signaling pathway#P00045>Neurotic#P01115 HELRO|EnsemblGenome=HelroG192325|UniProtKB=T1FTU0 T1FTU0 20212237 PTHR24006:SF937 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG121421|UniProtKB=T1EGR9 T1EGR9 20195769 PTHR12829:SF7 N6-ADENOSINE-METHYLTRANSFERASE N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT RNA metabolism protein#PC00031;RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG192266|UniProtKB=T1FTS0 T1FTS0 20212217 PTHR23003:SF3 RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN FI21236P1-RELATED nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG79843|UniProtKB=T1G3U3 T1G3U3 20215741 PTHR10188:SF6 L-ASPARAGINASE N(4)-(BETA-N-ACETYLGLUCOSAMINYL)-L-ASPARAGINASE protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG66727|UniProtKB=T1FYP5 T1FYP5 20213943 PTHR11933:SF5 TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;tRNA metabolic process#GO:0006399;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;tRNA wobble uridine modification#GO:0002098;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 RNA metabolism protein#PC00031;RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG67498|UniProtKB=T1FZ19 T1FZ19 20214067 PTHR13617:SF14 PROTEIN ABHD18 PROTEIN ABHD18 HELRO|EnsemblGenome=HelroG185022|UniProtKB=T1FMA7 T1FMA7 20209956 PTHR12170:SF3 MACROPHAGE ERYTHROBLAST ATTACHER-RELATED GH10162P transferase activity#GO:0016740;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG84585|UniProtKB=T1G5K6 T1G5K6 20216353 PTHR24046:SF7 SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING CUB DOMAIN-CONTAINING PROTEIN regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cell surface#GO:0009986;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 extracellular matrix glycoprotein#PC00100;extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG191798|UniProtKB=T1FTC1 T1FTC1 20212068 PTHR13477:SF0 MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49 LARGE RIBOSOMAL SUBUNIT PROTEIN ML49 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrial large ribosomal subunit#GO:0005762;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;organellar ribosome#GO:0000313;protein-containing complex#GO:0032991;large ribosomal subunit#GO:0015934;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840;mitochondrial protein-containing complex#GO:0098798 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG177880|UniProtKB=T1FCE9 T1FCE9 20206498 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG70373|UniProtKB=T1G055 T1G055 20214453 PTHR24351:SF216 RIBOSOMAL PROTEIN S6 KINASE PROTEIN KINASE C transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG156415|UniProtKB=T1ELV8 T1ELV8 20197558 PTHR13779:SF7 WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER ATPASE WRNIP1 ATP-dependent activity, acting on DNA#GO:0008094;molecular function activator activity#GO:0140677;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;molecular function regulator activity#GO:0098772;catalytic activity, acting on a nucleic acid#GO:0140640;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097;single-stranded DNA helicase activity#GO:0017116;enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated DNA replication#GO:0006261;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;nucleobase-containing compound biosynthetic process#GO:0034654;DNA biosynthetic process#GO:0071897;DNA synthesis involved in DNA repair#GO:0000731;aromatic compound biosynthetic process#GO:0019438;cellular response to stress#GO:0033554;DNA replication#GO:0006260;DNA metabolic process#GO:0006259 DNA helicase#PC00011;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG109371|UniProtKB=T1EES8 T1EES8 20195080 PTHR43690:SF18 NARDILYSIN INSULIN-DEGRADING ENZYME-RELATED metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG180381|UniProtKB=T1FFV1 T1FFV1 20207700 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162950|UniProtKB=T1ETE8 T1ETE8 20199848 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172429|UniProtKB=T1F5B5 T1F5B5 20204014 PTHR11801:SF67 SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION SUBFAMILY NOT NAMED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HELRO|EnsemblGenome=HelroG84384|UniProtKB=T1G5I2 T1G5I2 20216329 PTHR11537:SF105 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAL monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG165452|UniProtKB=T1EWT8 T1EWT8 20201038 PTHR33244:SF3 INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED PEPTIDASE A2 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175534|UniProtKB=T1F9D1 T1F9D1 20205430 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG184218|UniProtKB=T1FKS6 T1FKS6 20209425 PTHR10333:SF103 INHIBITOR OF GROWTH PROTEIN INHIBITOR OF GROWTH PROTEIN 3 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG165507|UniProtKB=T1EWX9 T1EWX9 20201079 PTHR46473:SF26 GH08155P LRRNT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG87174|UniProtKB=T1G6M9 T1G6M9 20216726 PTHR13160:SF4 OLIGOSACCHARYLTRANSFERASE COMPLEX SUBUNIT OSTC OLIGOSACCHARYLTRANSFERASE COMPLEX SUBUNIT OSTC membrane protein complex#GO:0098796;endoplasmic reticulum protein-containing complex#GO:0140534;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;oligosaccharyltransferase complex#GO:0008250;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG165049|UniProtKB=T1EW72 T1EW72 20200822 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG76399|UniProtKB=T1G2J7 T1G2J7 20215295 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG193071|UniProtKB=T1FUL4 T1FUL4 20212510 PTHR13547:SF1 FAMILY NOT NAMED MITOCHONDRIAL RIBONUCLEASE P CATALYTIC SUBUNIT catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 HELRO|EnsemblGenome=HelroG159889|UniProtKB=T1EPI2 T1EPI2 20198482 PTHR12598:SF0 COPPER HOMEOSTASIS PROTEIN CUTC COPPER HOMEOSTASIS PROTEIN CUTC HOMOLOG copper ion binding#GO:0005507;cation binding#GO:0043169;metal ion binding#GO:0046872;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;transition metal ion binding#GO:0046914 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG74052|UniProtKB=T1G1L7 T1G1L7 20214965 PTHR10856:SF0 CORONIN CORONIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG168600|UniProtKB=T1F0S3 T1F0S3 20202423 PTHR23121:SF9 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 transmembrane transporter activity#GO:0022857;sugar transmembrane transporter activity#GO:0051119;transporter activity#GO:0005215;carbohydrate transmembrane transporter activity#GO:0015144 transporter#PC00227 HELRO|EnsemblGenome=HelroG63203|UniProtKB=T1FXC2 T1FXC2 20213470 PTHR22851:SF0 U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN DDB1- AND CUL4-ASSOCIATED FACTOR 13 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG75751|UniProtKB=T1G297 T1G297 20215195 PTHR24270:SF61 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 apolipoprotein#PC00052 HELRO|EnsemblGenome=HelroG62886|UniProtKB=T1FX67 T1FX67 20213415 PTHR16470:SF0 UBIQUITIN DOMAIN-CONTAINING PROTEIN UBFD1 UBIQUITIN DOMAIN-CONTAINING PROTEIN UBFD1 cell adhesion molecule binding#GO:0050839;nucleic acid binding#GO:0003676;protein binding#GO:0005515;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 HELRO|EnsemblGenome=HelroG159632|UniProtKB=T1EP97 T1EP97 20198397 PTHR11176:SF57 BOULE-RELATED PROTEIN BOULE RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG174071|UniProtKB=T1F7K0 T1F7K0 20204799 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG178000|UniProtKB=T1FCL1 T1FCL1 20206560 PTHR10334:SF498 CYSTEINE-RICH SECRETORY PROTEIN-RELATED MIP16674P defense/immunity protein#PC00090 PI3 kinase pathway#P00048>scl-1#G01545 HELRO|EnsemblGenome=HelroG103856|UniProtKB=T1EDH9 T1EDH9 20194631 PTHR11599:SF44 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT BETA-RELATED hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;proteasome complex#GO:0000502;membrane-bounded organelle#GO:0043227;endopeptidase complex#GO:1905369;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protease#PC00190;protein modifying enzyme#PC00260 Parkinson disease#P00049>20S proteasome#P01227 HELRO|EnsemblGenome=HelroG176981|UniProtKB=T1FB33 T1FB33 20206032 PTHR10183:SF433 CALPAIN CALPAIN-A-RELATED cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protease#PC00190 Huntington disease#P00029>Calpain#P00788 HELRO|EnsemblGenome=HelroG109550|UniProtKB=T1EEU7 T1EEU7 20195099 PTHR10971:SF11 MRNA EXPORT FACTOR AND BUB3 MRNA EXPORT FACTOR RAE1 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;protein binding#GO:0005515;ubiquitin-like protein binding#GO:0032182;binding#GO:0005488;organic cyclic compound binding#GO:0097159;ubiquitin binding#GO:0043130 cellular localization#GO:0051641;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;cellular component organization#GO:0016043;cellular process#GO:0009987;RNA localization#GO:0006403;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000972;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;organelle organization#GO:0006996;chromosome organization#GO:0051276;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169 envelope#GO:0031975;nuclear pore#GO:0005643;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG169306|UniProtKB=T1F1R6 T1F1R6 20202766 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG184132|UniProtKB=T1FKM9 T1FKM9 20209378 PTHR24034:SF200 EGF-LIKE DOMAIN-CONTAINING PROTEIN EGF-LIKE AND EMI DOMAIN-CONTAINING PROTEIN 1 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG172725|UniProtKB=T1F5V0 T1F5V0 20204199 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG106206|UniProtKB=T1EE08 T1EE08 20194810 PTHR11573:SF6 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;oxidoreductase activity#GO:0016491;ATP binding#GO:0005524 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;carbohydrate derivative biosynthetic process#GO:1901137;organic cyclic compound metabolic process#GO:1901360;nucleobase-containing compound biosynthetic process#GO:0034654;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;nucleobase-containing small molecule metabolic process#GO:0055086 cytoplasm#GO:0005737;oxidoreductase complex#GO:1990204;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 reductase#PC00198;oxidoreductase#PC00176 De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>CDP Reductase#P02915;De novo purine biosynthesis#P02738>ADP reductase#P02902;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>UDP reductase#P02921;De novo purine biosynthesis#P02738>GDP reductase#P02909 HELRO|EnsemblGenome=HelroG191323|UniProtKB=T1FSV9 T1FSV9 20211906 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183764|UniProtKB=T1FK61 T1FK61 20209210 PTHR31882:SF11 TNFAIP3-INTERACTING PROTEIN COILED COIL FAMILY MEMBER HDA1 COMPLEX SUBUNIT 2 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 HELRO|EnsemblGenome=HelroG173811|UniProtKB=T1F794 T1F794 20204693 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG75559|UniProtKB=T1G264 T1G264 20215162 PTHR24031:SF68 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX51 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG190235|UniProtKB=T1FRT0 T1FRT0 20211527 PTHR46697:SF1 FORMIN-BINDING PROTEIN 4 FORMIN-BINDING PROTEIN 4 HELRO|EnsemblGenome=HelroG188962|UniProtKB=T1FQI4 T1FQI4 20211081 PTHR24112:SF66 LEUCINE-RICH REPEAT, ISOFORM F-RELATED LEUCINE-RICH REPEAT, ISOFORM F regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;regulation of organelle organization#GO:0033043;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament organization#GO:0110053;regulation of cellular component organization#GO:0051128;regulation of actin filament-based process#GO:0032970;cell motility#GO:0048870;cellular process#GO:0009987;cell migration#GO:0016477 cell leading edge#GO:0031252;lamellipodium#GO:0030027;cell projection#GO:0042995;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG110615|UniProtKB=T1EF36 T1EF36 20195188 PTHR23042:SF76 CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR HOMOLOG sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG165544|UniProtKB=T1EWZ9 T1EWZ9 20201099 PTHR13817:SF172 TITIN IG-LIKE DOMAIN-CONTAINING PROTEIN structural protein#PC00211 Axon guidance mediated by Slit/Robo#P00008>Robo#P00348 HELRO|EnsemblGenome=HelroG102569|UniProtKB=T1EDA4 T1EDA4 20194556 PTHR12268:SF14 E3 UBIQUITIN-PROTEIN LIGASE KCMF1 DYSTROPHIN-1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG168835|UniProtKB=T1F108 T1F108 20202508 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG73178|UniProtKB=T1G1B3 T1G1B3 20214861 PTHR11347:SF226 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE DUAL SPECIFICITY CALCIUM_CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric diester hydrolase activity#GO:0008081;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;cAMP-mediated signaling#GO:0019933;signaling#GO:0023052;cyclic-nucleotide-mediated signaling#GO:0019935 phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG189921|UniProtKB=T1FRH8 T1FRH8 20211425 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG88163|UniProtKB=T1G6Z2 T1G6Z2 20216839 PTHR20982:SF3 RIBOSOME RECYCLING FACTOR MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1 ribonucleoprotein complex binding#GO:0043021;ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;translation#GO:0006412;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 translation release factor#PC00225;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG99945|UniProtKB=T1G9V7 T1G9V7 20217853 PTHR11616:SF265 SODIUM/CHLORIDE DEPENDENT TRANSPORTER TRANSPORTER metal ion transport#GO:0030001;transmembrane transport#GO:0055085;amino acid transport#GO:0006865;organic anion transport#GO:0015711;organic acid transport#GO:0015849;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;nitrogen compound transport#GO:0071705;carboxylic acid transport#GO:0046942;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;organic substance transport#GO:0071702;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG162227|UniProtKB=T1ESD7 T1ESD7 20199487 PTHR24418:SF373 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE SRC42A protein tyrosine kinase activity#GO:0004713;non-membrane spanning protein tyrosine kinase activity#GO:0004715;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein binding#GO:0005515;catalytic activity, acting on a protein#GO:0140096;signaling receptor binding#GO:0005102;kinase activity#GO:0016301;protein kinase activity#GO:0004672 response to external biotic stimulus#GO:0043207;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;immune response#GO:0006955;developmental process#GO:0032502;cell communication#GO:0007154;cellular process#GO:0009987;defense response to symbiont#GO:0140546;regulation of biological process#GO:0050789;immune system process#GO:0002376;response to stimulus#GO:0050896;response to external stimulus#GO:0009605;cell differentiation#GO:0030154;enzyme-linked receptor protein signaling pathway#GO:0007167;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to other organism#GO:0098542;regulation of cellular process#GO:0050794;response to other organism#GO:0051707;cell surface receptor signaling pathway#GO:0007166;biological process involved in interspecies interaction between organisms#GO:0044419;biological regulation#GO:0065007;innate immune response#GO:0045087;defense response#GO:0006952;signaling#GO:0023052;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169 non-receptor tyrosine protein kinase#PC00168 Parkinson disease#P00049>Src kinase#P01230;Integrin signalling pathway#P00034>Src#P00940 HELRO|EnsemblGenome=HelroG167589|UniProtKB=T1EZI9 T1EZI9 20201989 PTHR32026:SF10 METHYLTRANSFERASE-LIKE PROTEIN 24 METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG192853|UniProtKB=T1FUD0 T1FUD0 20212426 PTHR45868:SF80 HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 33-RELATED F15K9.8-RELATED HELRO|EnsemblGenome=HelroG194840|UniProtKB=T1FWH0 T1FWH0 20213165 PTHR22684:SF0 NULP1-RELATED RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25 protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG165722|UniProtKB=T1EX75 T1EX75 20201175 PTHR31815:SF1 AGAP005329-PA TRANSMEMBRANE PROTEIN 200C HELRO|EnsemblGenome=HelroG76772|UniProtKB=T1G2P3 T1G2P3 20215341 PTHR11006:SF124 PROTEIN ARGININE N-METHYLTRANSFERASE ARGININE METHYLTRANSFERASE 1-RELATED N-methyltransferase activity#GO:0008170;histone modifying activity#GO:0140993;transferase activity#GO:0016740;catalytic activity#GO:0003824;histone methyltransferase activity#GO:0042054;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a protein#GO:0140096;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein methyltransferase activity#GO:0008276 protein-DNA complex organization#GO:0071824;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;cellular component organization#GO:0016043;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;methylation#GO:0032259;macromolecule methylation#GO:0043414;nitrogen compound metabolic process#GO:0006807;protein-containing complex organization#GO:0043933;chromatin organization#GO:0006325;protein metabolic process#GO:0019538;chromatin remodeling#GO:0006338;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG63233|UniProtKB=T1FXC7 T1FXC7 20213475 PTHR20996:SF1 NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1 NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;catalytic complex#GO:1902494;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;protein serine/threonine phosphatase complex#GO:0008287;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG193411|UniProtKB=T1FUY9 T1FUY9 20212635 PTHR43999:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 2 DNAJ HOMOLOG SUBFAMILY C MEMBER 2 binding#GO:0005488;ribosome binding#GO:0043022;ribonucleoprotein complex binding#GO:0043021;heat shock protein binding#GO:0031072;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;protein-folding chaperone binding#GO:0051087;Hsp70 protein binding#GO:0030544 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;'de novo' protein folding#GO:0006458;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG186120|UniProtKB=T1FNP3 T1FNP3 20210440 PTHR11999:SF167 GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE AROMATIC-L-AMINO-ACID DECARBOXYLASE lyase activity#GO:0016829;carboxy-lyase activity#GO:0016831;carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 decarboxylase#PC00089 Nicotine pharmacodynamics pathway#P06587>DDC#P06608;5-Hydroxytryptamine biosynthesis#P04371>Aromatic L-amino acid decarboxylase#P04400;Dopamine receptor mediated signaling pathway#P05912>DOPA decarb.#P05961;Adrenaline and noradrenaline biosynthesis#P00001>DOPA decarb.#P00066 HELRO|EnsemblGenome=HelroG191792|UniProtKB=T1FTB9 T1FTB9 20212066 PTHR10127:SF861 DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING DORSAL-VENTRAL PATTERNING PROTEIN TOLLOID-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 SCW signaling pathway#P06216>TLD#P06327;DPP-SCW signaling pathway#P06212>TLD#P06264;TGF-beta signaling pathway#P00052>TGFbeta#P01286;DPP signaling pathway#P06213>TLD#P06283;BMP/activin signaling pathway-drosophila#P06211>TLD#P06249 HELRO|EnsemblGenome=HelroG185375|UniProtKB=T1FMQ7 T1FMQ7 20210106 PTHR11710:SF0 40S RIBOSOMAL PROTEIN S19 40S RIBOSOMAL PROTEIN S19 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;protein-RNA complex assembly#GO:0022618;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;ribonucleoprotein complex biogenesis#GO:0022613;protein-containing complex assembly#GO:0065003;ribosome biogenesis#GO:0042254;cellular component organization#GO:0016043;protein-RNA complex organization#GO:0071826;non-membrane-bounded organelle assembly#GO:0140694;cellular process#GO:0009987;ribosomal small subunit biogenesis#GO:0042274 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;cytosol#GO:0005829;small ribosomal subunit#GO:0015935;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG193470|UniProtKB=T1FV12 T1FV12 20212658 PTHR42776:SF4 SERINE PEPTIDASE S9 FAMILY MEMBER ACYLAMINO-ACID-RELEASING ENZYME hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG110936|UniProtKB=T1EF64 T1EF64 20195216 PTHR43261:SF1 TRANSLATION ELONGATION FACTOR G-RELATED RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cellular component disassembly#GO:0022411;cellular process#GO:0009987;organelle disassembly#GO:1903008;organelle organization#GO:0006996 translation elongation factor#PC00222;translational protein#PC00263 HELRO|EnsemblGenome=HelroG72786|UniProtKB=T1G156 T1G156 20214804 PTHR11878:SF76 SODIUM/CALCIUM EXCHANGER CALX-BETA DOMAIN-CONTAINING PROTEIN calcium ion transmembrane transporter activity#GO:0015085;secondary active transmembrane transporter activity#GO:0015291;inorganic molecular entity transmembrane transporter activity#GO:0015318;antiporter activity#GO:0015297;transmembrane transporter activity#GO:0022857;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;inorganic cation transmembrane transporter activity#GO:0022890;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;calcium ion transport#GO:0006816;localization#GO:0051179;calcium ion import#GO:0070509;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;calcium ion transmembrane import into cytosol#GO:0097553;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;sodium ion transmembrane transport#GO:0035725 synapse#GO:0045202;neuron projection#GO:0043005;cell junction#GO:0030054;postsynapse#GO:0098794;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;sarcolemma#GO:0042383;axon#GO:0030424;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG67964|UniProtKB=T1FZ86 T1FZ86 20214134 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG176127|UniProtKB=T1FA64 T1FA64 20205713 PTHR24121:SF32 NO MECHANORECEPTOR POTENTIAL C, ISOFORM D-RELATED DEATH DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG65173|UniProtKB=T1FY41 T1FY41 20213739 PTHR45920:SF7 FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I FORMIN-G HELRO|EnsemblGenome=HelroG174241|UniProtKB=T1F7V2 T1F7V2 20204901 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172658|UniProtKB=T1F5Q9 T1F5Q9 20204158 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cell communication#GO:0007154;cellular process#GO:0009987;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;Notch signaling pathway#GO:0007219 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG180027|UniProtKB=T1FFD1 T1FFD1 20207530 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG180364|UniProtKB=T1FFU2 T1FFU2 20207691 PTHR22792:SF62 LUPUS LA PROTEIN-RELATED LA-RELATED PROTEIN 7 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG67454|UniProtKB=T1FZ11 T1FZ11 20214059 PTHR12756:SF4 CYTOSOLIC CARBOXYPEPTIDASE PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG95507|UniProtKB=T1G962 T1G962 20217609 PTHR12040:SF0 ANTI-SILENCING PROTEIN 1 HISTONE CHAPERONE ASF1 protein binding#GO:0005515;binding#GO:0005488;histone binding#GO:0042393 cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;protein-DNA complex organization#GO:0071824;cellular component organization#GO:0016043;cellular process#GO:0009987;protein-containing complex organization#GO:0043933 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;chromosome#GO:0005694;chromatin#GO:0000785;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG71671|UniProtKB=T1G0Q0 T1G0Q0 20214648 PTHR43788:SF16 DNA2/NAM7 HELICASE FAMILY MEMBER HELICASE WITH ZINC FINGER 2 catalytic activity, acting on a nucleic acid#GO:0140640;ATP-dependent activity, acting on DNA#GO:0008094;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG165380|UniProtKB=T1EWP1 T1EWP1 20200991 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN SI:DKEY-17M8.2 HELRO|EnsemblGenome=HelroG194484|UniProtKB=T1FW40 T1FW40 20213036 PTHR46182:SF2 FI19480P1 FI19480P1 cell differentiation#GO:0030154;cellular developmental process#GO:0048869;system development#GO:0048731;neurogenesis#GO:0022008;anatomical structure development#GO:0048856;neuron migration#GO:0001764;multicellular organism development#GO:0007275;developmental process#GO:0032502;multicellular organismal process#GO:0032501;cell motility#GO:0048870;generation of neurons#GO:0048699;cellular process#GO:0009987;nervous system development#GO:0007399;cell migration#GO:0016477 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG165356|UniProtKB=T1EWM7 T1EWM7 20200977 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193598|UniProtKB=T1FV58 T1FV58 20212704 PTHR19212:SF0 LEUCINE RICH REPEAT IN FLII INTERACTING PROTEIN LD07988P DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG162676|UniProtKB=T1ET02 T1ET02 20199702 PTHR28532:SF1 GEO13458P1 ORAL CANCER OVEREXPRESSED 1 HELRO|EnsemblGenome=HelroG159485|UniProtKB=T1EP32 T1EP32 20198332 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184381|UniProtKB=T1FL34 T1FL34 20209533 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN SI:DKEY-17M8.2 HELRO|EnsemblGenome=HelroG182281|UniProtKB=T1FI09 T1FI09 20208458 PTHR36191:SF1 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166015|UniProtKB=T1EXL4 T1EXL4 20201314 PTHR12449:SF22 DEATH DOMAIN-CONTAINING PROTEIN NUCLEOLAR PROTEIN 4 HELRO|EnsemblGenome=HelroG171779|UniProtKB=T1F4N7 T1F4N7 20203786 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG72755|UniProtKB=T1G149 T1G149 20214797 PTHR33447:SF2 GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE transferase activity#GO:0016740;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824 cellular response to stimulus#GO:0051716;secondary metabolic process#GO:0019748;cellular response to chemical stimulus#GO:0070887;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;amide biosynthetic process#GO:0043604;response to stimulus#GO:0050896;detoxification#GO:0098754;peptide biosynthetic process#GO:0043043;response to stress#GO:0006950;secondary metabolite biosynthetic process#GO:0044550;response to chemical#GO:0042221;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;response to toxic substance#GO:0009636;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG65392|UniProtKB=T1FY71 T1FY71 20213769 PTHR10075:SF100 BASIGIN RELATED FASCICLIN-2 cell adhesion molecule binding#GO:0050839;cell-cell adhesion mediator activity#GO:0098632;protein binding#GO:0005515;binding#GO:0005488 neuron projection guidance#GO:0097485;cell recognition#GO:0008037;neurogenesis#GO:0022008;cell projection organization#GO:0030030;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;axonogenesis#GO:0007409;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156;cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cell morphogenesis#GO:0000902;cellular process#GO:0009987;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure development#GO:0048856;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;axon#GO:0030424 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG177395|UniProtKB=T1FBM2 T1FBM2 20206221 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG109014|UniProtKB=T1EEQ0 T1EEQ0 20195052 PTHR22883:SF414 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC24-RELATED palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular localization#GO:0051641;macromolecule localization#GO:0033036;macromolecule modification#GO:0043412;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;protein palmitoylation#GO:0018345;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;localization within membrane#GO:0051668;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein localization to membrane#GO:0072657;organonitrogen compound biosynthetic process#GO:1901566;protein targeting#GO:0006605;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;protein acylation#GO:0043543;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipoprotein biosynthetic process#GO:0042158;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;lipoprotein metabolic process#GO:0042157 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG179041|UniProtKB=T1FE32 T1FE32 20207081 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG89102|UniProtKB=T1G785 T1G785 20216932 PTHR45973:SF12 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED DYNEIN REGULATORY COMPLEX SUBUNIT 3 membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cilium#GO:0005929;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG185364|UniProtKB=T1FMQ4 T1FMQ4 20210103 PTHR42681:SF1 MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL transferase activity#GO:0016740;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824 organic acid biosynthetic process#GO:0016053;lipid metabolic process#GO:0006629;oxoacid metabolic process#GO:0043436;monocarboxylic acid biosynthetic process#GO:0072330;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;fatty acid metabolic process#GO:0006631;small molecule biosynthetic process#GO:0044283;cellular lipid metabolic process#GO:0044255;carboxylic acid metabolic process#GO:0019752;small molecule metabolic process#GO:0044281;fatty acid biosynthetic process#GO:0006633;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG157586|UniProtKB=T1EMD5 T1EMD5 20197735 PTHR44154:SF1 QUINONE OXIDOREDUCTASE QUINONE OXIDOREDUCTASE oxidoreductase#PC00176 Huntington disease#P00029>PIG3#G01535 HELRO|EnsemblGenome=HelroG189765|UniProtKB=T1FRC8 T1FRC8 20211375 PTHR46459:SF1 E1A-BINDING PROTEIN P400-RELATED E1A-BINDING PROTEIN P400 protein-containing complex binding#GO:0044877;binding#GO:0005488;chromatin binding#GO:0003682 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;NuA4 histone acetyltransferase complex#GO:0035267;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;chromosome#GO:0005694 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG168268|UniProtKB=T1F0D5 T1F0D5 20202285 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER FI01427P membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG90889|UniProtKB=T1G7X4 T1G7X4 20217171 PTHR11827:SF73 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS KAZACHOC, ISOFORM G inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium ion transmembrane transporter activity#GO:0015079;symporter activity#GO:0015293;chloride transmembrane transporter activity#GO:0015108;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 inorganic ion homeostasis#GO:0098771;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;inorganic anion transmembrane transport#GO:0098661;import across plasma membrane#GO:0098739;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;inorganic anion transport#GO:0015698;potassium ion transport#GO:0006813;regulation of anatomical structure size#GO:0090066;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;monoatomic anion transmembrane transport#GO:0098656;chloride transport#GO:0006821;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;cellular component organization#GO:0016043;cellular process#GO:0009987;chemical homeostasis#GO:0048878;regulation of cellular component size#GO:0032535;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;regulation of cell size#GO:0008361;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;potassium ion import across plasma membrane#GO:1990573 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG193822|UniProtKB=T1FVE2 T1FVE2 20212788 PTHR11360:SF286 MONOCARBOXYLATE TRANSPORTER GH22266P transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;monocarboxylic acid transmembrane transporter activity#GO:0008028;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;monocarboxylic acid transport#GO:0015718;establishment of localization#GO:0051234;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942 transporter#PC00227 HELRO|EnsemblGenome=HelroG117113|UniProtKB=T1EGK2 T1EGK2 20195703 PTHR23280:SF21 4.1 G PROTEIN PROTEIN 4.1 HOMOLOG cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG157132|UniProtKB=T1EM69 T1EM69 20197669 PTHR23147:SF133 SERINE/ARGININE RICH SPLICING FACTOR SERINE_ARGININE-RICH SPLICING FACTOR 10 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;nuclear speck#GO:0016607;organelle#GO:0043226;nuclear body#GO:0016604;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG103188|UniProtKB=T1EDE9 T1EDE9 20194601 PTHR20981:SF6 60S RIBOSOMAL PROTEIN L21 60S RIBOSOMAL PROTEIN L21 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG160181|UniProtKB=T1EPX7 T1EPX7 20198627 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG185464|UniProtKB=T1FMU8 T1FMU8 20210147 PTHR45696:SF10 60S ACIDIC RIBOSOMAL PROTEIN P1 LARGE RIBOSOMAL SUBUNIT PROTEIN P1 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG178248|UniProtKB=T1FCZ7 T1FCZ7 20206696 PTHR13264:SF5 GCIP-INTERACTING PROTEIN P29 PRE-MRNA-SPLICING FACTOR SYF2 ribonucleoprotein complex#GO:1990904;catalytic step 2 spliceosome#GO:0071013;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;post-mRNA release spliceosomal complex#GO:0071014;spliceosomal complex#GO:0005681;Prp19 complex#GO:0000974;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG98055|UniProtKB=T1G9K3 T1G9K3 20217749 PTHR45689:SF5 I[[H]] CHANNEL, ISOFORM E I[[H]] CHANNEL, ISOFORM E monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;sodium ion transport#GO:0006814;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;regulation of membrane depolarization#GO:0003254;sodium ion transmembrane transport#GO:0035725;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG86808|UniProtKB=T1G6H1 T1G6H1 20216668 PTHR45691:SF6 PROTEIN DIAPHANOUS PROTEIN DIAPHANOUS cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-containing complex assembly#GO:0065003;actin polymerization or depolymerization#GO:0008154;actin filament polymerization#GO:0030041;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;protein polymerization#GO:0051258;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036 supramolecular complex#GO:0099080;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;supramolecular fiber#GO:0099512;supramolecular polymer#GO:0099081;actin filament#GO:0005884;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG115686|UniProtKB=T1EGA0 T1EGA0 20195602 PTHR24223:SF443 ATP-BINDING CASSETTE SUB-FAMILY C MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG159582|UniProtKB=T1EP70 T1EP70 20198370 PTHR46673:SF1 4F2 CELL-SURFACE ANTIGEN HEAVY CHAIN 4F2 CELL-SURFACE ANTIGEN HEAVY CHAIN aromatic amino acid transmembrane transporter activity#GO:0015173;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;branched-chain amino acid transmembrane transporter activity#GO:0015658;organic acid transmembrane transporter activity#GO:0005342;L-amino acid transmembrane transporter activity#GO:0015179;organic anion transmembrane transporter activity#GO:0008514;amino acid transmembrane transporter activity#GO:0015171;neutral L-amino acid transmembrane transporter activity#GO:0015175;transporter activity#GO:0005215 leucine transport#GO:0015820;neutral amino acid transport#GO:0015804;L-amino acid transport#GO:0015807;transmembrane transport#GO:0055085;organic anion transport#GO:0015711;amino acid transport#GO:0006865;organic acid transport#GO:0015849;alanine transport#GO:0032328;transport#GO:0006810;branched-chain amino acid transport#GO:0015803;nitrogen compound transport#GO:0071705;carboxylic acid transport#GO:0046942;cellular process#GO:0009987;amino acid import across plasma membrane#GO:0089718;carboxylic acid transmembrane transport#GO:1905039;localization#GO:0051179;organic substance transport#GO:0071702;import across plasma membrane#GO:0098739;amino acid transmembrane transport#GO:0003333;establishment of localization#GO:0051234;L-alpha-amino acid transmembrane transport#GO:1902475;organic acid transmembrane transport#GO:1903825;import into cell#GO:0098657 basal plasma membrane#GO:0009925;basolateral plasma membrane#GO:0016323;plasma membrane region#GO:0098590;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;basal part of cell#GO:0045178;membrane#GO:0016020;apical plasma membrane#GO:0016324;apical part of cell#GO:0045177;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG92276|UniProtKB=T1G8D7 T1G8D7 20217334 PTHR10026:SF70 CYCLIN CYCLIN-Q protein kinase regulator activity#GO:0019887;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 kinase activator#PC00138 HELRO|EnsemblGenome=HelroG85816|UniProtKB=T1G630 T1G630 20216527 PTHR10183:SF433 CALPAIN CALPAIN-A-RELATED cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protease#PC00190 Huntington disease#P00029>Calpain#P00788 HELRO|EnsemblGenome=HelroG189696|UniProtKB=T1FR96 T1FR96 20211343 PTHR24404:SF110 ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG145703|UniProtKB=T1EJM2 T1EJM2 20196772 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN SI:DKEY-17M8.2 HELRO|EnsemblGenome=HelroG86301|UniProtKB=T1G6A1 T1G6A1 20216598 PTHR11929:SF145 ALPHA- 1,3 -FUCOSYLTRANSFERASE ALPHA-(1,3)-FUCOSYLTRANSFERASE FUT-1 transferase activity#GO:0016740;fucosyltransferase activity#GO:0008417;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycosylation#GO:0070085;metabolic process#GO:0008152 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG181421|UniProtKB=T1FGZ8 T1FGZ8 20208097 PTHR15696:SF0 SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7 TELOMERASE-BINDING PROTEIN EST1A telomeric DNA binding#GO:0042162;sequence-specific DNA binding#GO:0043565;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;mRNA catabolic process#GO:0006402;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;negative regulation of cellular process#GO:0048523;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;nuclear-transcribed mRNA catabolic process#GO:0000956;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG111242|UniProtKB=T1EF97 T1EF97 20195249 PTHR11848:SF309 TGF-BETA FAMILY INHIBIN BETA CHAIN molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;binding#GO:0005488;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;protein binding#GO:0005515;signaling receptor binding#GO:0005102 extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 BMP/activin signaling pathway-drosophila#P06211>Full-length BMP orthologous ligand#P06256;TGF-beta signaling pathway#P00052>TGFbeta#P01286;Activin beta signaling pathway#P06210>activinbeta full length#P06232;BMP/activin signaling pathway-drosophila#P06211>BMP/activin orthologous ligand#P06251;Activin beta signaling pathway#P06210>activin beta#P06234 HELRO|EnsemblGenome=HelroG63316|UniProtKB=T1FXE2 T1FXE2 20213490 PTHR43827:SF3 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG113249|UniProtKB=T1EFQ9 T1EFQ9 20195411 PTHR13952:SF5 U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;snRNA binding#GO:0017069;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;mRNA splicing, via spliceosome#GO:0000398;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;U1 snRNP#GO:0005685;U2-type spliceosomal complex#GO:0005684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;U2-type prespliceosome#GO:0071004;precatalytic spliceosome#GO:0071011;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG171000|UniProtKB=T1F3P2 T1F3P2 20203441 PTHR10457:SF7 MEVALONATE KINASE/GALACTOKINASE GALACTOKINASE-RELATED transferase activity, transferring phosphorus-containing groups#GO:0016772;carbohydrate kinase activity#GO:0019200;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 monosaccharide metabolic process#GO:0005996;hexose metabolic process#GO:0019318;carbohydrate metabolic process#GO:0005975;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;carbohydrate kinase#PC00065 Fructose galactose metabolism#P02744>Galactokinase#P02960 HELRO|EnsemblGenome=HelroG189566|UniProtKB=T1FR58 T1FR58 20211305 PTHR10582:SF28 TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN NANCHUNG, ISOFORM B calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;inorganic cation transmembrane transporter activity#GO:0022890;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;calcium ion transport#GO:0006816;localization#GO:0051179;calcium ion import#GO:0070509;import across plasma membrane#GO:0098739;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;calcium ion transmembrane import into cytosol#GO:0097553;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG81474|UniProtKB=T1G4E7 T1G4E7 20215945 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG66947|UniProtKB=T1FYT7 T1FYT7 20213985 PTHR12992:SF24 NUDIX HYDROLASE PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;heterocycle catabolic process#GO:0046700;organonitrogen compound catabolic process#GO:1901565;ribonucleotide catabolic process#GO:0009261;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;cellular nitrogen compound catabolic process#GO:0044270;purine-containing compound catabolic process#GO:0072523;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;purine nucleotide catabolic process#GO:0006195;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;purine ribonucleotide catabolic process#GO:0009154;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;purine nucleotide metabolic process#GO:0006163;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;nucleoside phosphate catabolic process#GO:1901292;carbohydrate derivative catabolic process#GO:1901136;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;nucleotide catabolic process#GO:0009166;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;organophosphate catabolic process#GO:0046434;primary metabolic process#GO:0044238;aromatic compound catabolic process#GO:0019439;organic cyclic compound catabolic process#GO:1901361;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;nucleotide metabolic process#GO:0009117;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG76554|UniProtKB=T1G2L5 T1G2L5 20215313 PTHR21230:SF1 VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED GOLGI SNAP RECEPTOR COMPLEX MEMBER 2 molecular adaptor activity#GO:0060090;protein binding#GO:0005515;SNAP receptor activity#GO:0005484;binding#GO:0005488;SNARE binding#GO:0000149;protein-macromolecule adaptor activity#GO:0030674 localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;vesicle fusion#GO:0006906;membrane fusion#GO:0061025;establishment of localization#GO:0051234;membrane organization#GO:0061024;organelle organization#GO:0006996;organelle membrane fusion#GO:0090174;transport#GO:0006810;vesicle-mediated transport#GO:0016192;vesicle organization#GO:0016050;cellular component organization#GO:0016043;cellular process#GO:0009987;organelle fusion#GO:0048284 bounding membrane of organelle#GO:0098588;endosome#GO:0005768;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular membrane-bounded organelle#GO:0043231;SNARE complex#GO:0031201;late endosome membrane#GO:0031902;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endosome membrane#GO:0010008;vesicle#GO:0031982;intracellular organelle#GO:0043229;transport vesicle membrane#GO:0030658;endoplasmic reticulum subcompartment#GO:0098827;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;membrane protein complex#GO:0098796;ER to Golgi transport vesicle membrane#GO:0012507;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;membrane#GO:0016020;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;coated vesicle membrane#GO:0030662;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 SNARE protein#PC00034 HELRO|EnsemblGenome=HelroG164973|UniProtKB=T1EW17 T1EW17 20200767 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190193|UniProtKB=T1FRR9 T1FRR9 20211516 PTHR10288:SF338 KH DOMAIN CONTAINING RNA BINDING PROTEIN IGF-II MRNA-BINDING PROTEIN, ISOFORM L nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159;mRNA 3'-UTR binding#GO:0003730 developmental process#GO:0032502;multicellular organism development#GO:0007275;nervous system development#GO:0007399;regulation of biological process#GO:0050789;system development#GO:0048731;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG114685|UniProtKB=T1EG39 T1EG39 20195541 PTHR21243:SF15 PROTEIN SCAI PROTEIN SCAI transcription coregulator activity#GO:0003712;molecular adaptor activity#GO:0060090;transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;protein-macromolecule adaptor activity#GO:0030674 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG193939|UniProtKB=T1FVH9 T1FVH9 20212825 PTHR12280:SF20 PANTOTHENATE KINASE 4'-PHOSPHOPANTETHEINE PHOSPHATASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 kinase#PC00137 Coenzyme A biosynthesis#P02736>Pantothenate kinase#P02885 HELRO|EnsemblGenome=HelroG150937|UniProtKB=T1EKH9 T1EKH9 20197079 PTHR10410:SF2 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED BRCA1_BRCA2-CONTAINING COMPLEX SUBUNIT 3 metallopeptidase activity#GO:0008237;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;protein binding#GO:0005515;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;modification-dependent protein binding#GO:0140030;polyubiquitin modification-dependent protein binding#GO:0031593 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;BRCA1-A complex#GO:0070531;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG156416|UniProtKB=T1ELV9 T1ELV9 20197559 PTHR14564:SF4 MICOS COMPLEX SUBUNIT MIC26 / MIC27 FAMILY MEMBER MICOS COMPLEX SUBUNIT cellular component organization or biogenesis#GO:0071840;membrane organization#GO:0061024;organelle organization#GO:0006996;cellular component organization#GO:0016043;mitochondrial membrane organization#GO:0007006;mitochondrion organization#GO:0007005;cellular process#GO:0009987;inner mitochondrial membrane organization#GO:0007007 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;mitochondrial protein-containing complex#GO:0098798 HELRO|EnsemblGenome=HelroG184437|UniProtKB=T1FL74 T1FL74 20209573 PTHR24125:SF5 ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING PROTEIN ANKYRIN REPEAT PROTEIN HELRO|EnsemblGenome=HelroG186059|UniProtKB=T1FNL9 T1FNL9 20210416 PTHR47979:SF24 DRAB11-RELATED SMALL MONOMERIC GTPASE GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;anion binding#GO:0043168;ion binding#GO:0043167 localization#GO:0051179;regulation of biological process#GO:0050789;regulation of endocytosis#GO:0030100;regulation of transport#GO:0051049;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;transport#GO:0006810;biological regulation#GO:0065007;regulation of localization#GO:0032879;vesicle-mediated transport#GO:0016192;regulation of cellular component organization#GO:0051128;cellular process#GO:0009987;regulation of vesicle-mediated transport#GO:0060627 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG159026|UniProtKB=T1ENH8 T1ENH8 20198128 PTHR13024:SF0 MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN, LARGE SUBUNIT MICROSOMAL TRIACYLGLYCEROL TRANSFER PROTEIN phospholipid transporter activity#GO:0005548;transporter activity#GO:0005215;lipid transporter activity#GO:0005319 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;lipoprotein metabolic process#GO:0042157;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 intracellular membrane-bounded organelle#GO:0043231;basolateral plasma membrane#GO:0016323;Golgi apparatus#GO:0005794;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;basal plasma membrane#GO:0009925;endomembrane system#GO:0012505;plasma membrane region#GO:0098590;membrane-bounded organelle#GO:0043227;basal part of cell#GO:0045178;endoplasmic reticulum#GO:0005783;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG72745|UniProtKB=T1G147 T1G147 20214795 PTHR38537:SF8 JITTERBUG, ISOFORM N FILAMIN-A HELRO|EnsemblGenome=HelroG165872|UniProtKB=T1EXD8 T1EXD8 20201238 PTHR23059:SF4 CYSTEINE AND HISTIDINE-RICH PROTEIN 1 ZINC FINGER TRAF-TYPE-CONTAINING PROTEIN 1 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG160078|UniProtKB=T1EPR1 T1EPR1 20198561 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG114981|UniProtKB=T1EG56 T1EG56 20195558 PTHR15336:SF0 UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL mitochondrial ATP synthesis coupled electron transport#GO:0042775;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;respiratory electron transport chain#GO:0022904;aerobic electron transport chain#GO:0019646;oxidative phosphorylation#GO:0006119;generation of precursor metabolites and energy#GO:0006091;electron transport chain#GO:0022900;ATP synthesis coupled electron transport#GO:0042773;cellular metabolic process#GO:0044237;mitochondrial electron transport, ubiquinol to cytochrome c#GO:0006122;cellular process#GO:0009987;energy derivation by oxidation of organic compounds#GO:0015980;metabolic process#GO:0008152 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;cytochrome complex#GO:0070069;respiratory chain complex#GO:0098803;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transporter complex#GO:1990351;oxidoreductase complex#GO:1990204;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;respirasome#GO:0070469;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;mitochondrial respirasome#GO:0005746;transmembrane transporter complex#GO:1902495;inner mitochondrial membrane protein complex#GO:0098800;mitochondrial respiratory chain complex III#GO:0005750;membrane-bounded organelle#GO:0043227;mitochondrial protein-containing complex#GO:0098798 reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG176895|UniProtKB=T1FB12 T1FB12 20206011 PTHR24365:SF541 TOLL-LIKE RECEPTOR PROTEIN TOLL-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Toll pathway-drosophila#P06217>TL#P06337;Toll receptor signaling pathway#P00054>TLR#P01346 HELRO|EnsemblGenome=HelroG100213|UniProtKB=T1ECY9 T1ECY9 20194441 PTHR24056:SF546 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 12 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of transcription elongation by RNA polymerase II#GO:0034243;positive regulation of transcription elongation by RNA polymerase II#GO:0032968;positive regulation of RNA biosynthetic process#GO:1902680;macromolecule modification#GO:0043412;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;protein modification process#GO:0036211;positive regulation of DNA-templated transcription, elongation#GO:0032786;regulation of RNA biosynthetic process#GO:2001141;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;phosphorylation#GO:0016310;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;protein metabolic process#GO:0019538;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;regulation of DNA-templated transcription elongation#GO:0032784;regulation of DNA-templated transcription#GO:0006355;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG67587|UniProtKB=T1FZ26 T1FZ26 20214074 PTHR20914:SF9 LY6/PLAUR DOMAIN-CONTAINING PROTEIN 8 COILED, ISOFORM A scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG174563|UniProtKB=T1F893 T1F893 20205042 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG87870|UniProtKB=T1G6W2 T1G6W2 20216809 PTHR13531:SF6 GEO07735P1-RELATED-RELATED TMEM (HUMAN TRANSMEMBRANE PROTEIN) HOMOLOG organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;non-motile cilium assembly#GO:1905515;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cilium#GO:0005929;ciliary transition zone#GO:0035869 HELRO|EnsemblGenome=HelroG140151|UniProtKB=T1EJ00 T1EJ00 20196550 PTHR31428:SF6 RGM DOMAIN FAMILY MEMBER DRAG-1 REPULSIVE GUIDANCE MOLECULE B HOMOLOG DRAG-1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular response to endogenous stimulus#GO:0071495;response to growth factor#GO:0070848;BMP signaling pathway#GO:0030509;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;cellular response to BMP stimulus#GO:0071773;response to stimulus#GO:0050896;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;enzyme-linked receptor protein signaling pathway#GO:0007167;response to endogenous stimulus#GO:0009719;regulation of cellular process#GO:0050794;cellular response to growth factor stimulus#GO:0071363;cell surface receptor signaling pathway#GO:0007166;transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0007178;biological regulation#GO:0065007;response to BMP#GO:0071772;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG170607|UniProtKB=T1F384 T1F384 20203283 PTHR19441:SF95 WHEY ACDIC PROTEIN WAP PERLWAPIN ISOFORM X1 peptidase inhibitor activity#GO:0030414;molecular function regulator activity#GO:0098772;serine-type endopeptidase inhibitor activity#GO:0004867;peptidase regulator activity#GO:0061134;enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;endopeptidase regulator activity#GO:0061135;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG115822|UniProtKB=T1EGA9 T1EGA9 20195611 PTHR11353:SF84 CHAPERONIN T-COMPLEX PROTEIN 1 SUBUNIT ALPHA protein binding#GO:0005515;unfolded protein binding#GO:0051082;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;chaperonin-containing T-complex#GO:0005832;protein folding chaperone complex#GO:0101031;intracellular anatomical structure#GO:0005622 chaperonin#PC00073 HELRO|EnsemblGenome=HelroG194316|UniProtKB=T1FVX3 T1FVX3 20212969 PTHR16002:SF4 TRANSMEMBRANE PROTEIN 248-LIKE TMEM248_TMEM219 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG187296|UniProtKB=T1FP85 T1FP85 20210632 PTHR10996:SF277 2-HYDROXYACID DEHYDROGENASE-RELATED GLYOXYLATE REDUCTASE_HYDROXYPYRUVATE REDUCTASE oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG123984|UniProtKB=T1EGZ8 T1EGZ8 20195848 PTHR16509:SF1 FAMILY NOT NAMED MANGANESE-DEPENDENT ADP-RIBOSE_CDP-ALCOHOL DIPHOSPHATASE HELRO|EnsemblGenome=HelroG185947|UniProtKB=T1FNH0 T1FNH0 20210367 PTHR10259:SF11 THIOPURINE S-METHYLTRANSFERASE THIOPURINE S-METHYLTRANSFERASE methyltransferase activity#GO:0008168;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757 methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG62217|UniProtKB=T1FWX1 T1FWX1 20213319 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185542|UniProtKB=T1FMY5 T1FMY5 20210184 PTHR12001:SF69 GERANYLGERANYL PYROPHOSPHATE SYNTHASE ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1 prenyltransferase activity#GO:0004659;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;cellular lipid metabolic process#GO:0044255;isoprenoid metabolic process#GO:0006720;metabolic process#GO:0008152;isoprenoid biosynthetic process#GO:0008299;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704 metabolite interconversion enzyme#PC00262 Cholesterol biosynthesis#P00014>Dimethylallyl trans-transferase#P00490 HELRO|EnsemblGenome=HelroG167463|UniProtKB=T1EZE6 T1EZE6 20201946 PTHR43827:SF13 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE ALDO_KETO REDUCTASE FAMILY PROTEIN oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG115085|UniProtKB=T1EG62 T1EG62 20195564 PTHR23257:SF969 SERINE-THREONINE PROTEIN KINASE INTEGRIN-LINKED PROTEIN KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG188964|UniProtKB=T1FQI5 T1FQI5 20211082 PTHR11686:SF9 GAMMA GLUTAMYL TRANSPEPTIDASE RE13973P hydrolase activity#GO:0016787;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 sulfur compound metabolic process#GO:0006790;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;peptide catabolic process#GO:0043171;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;cellular process#GO:0009987;glutathione metabolic process#GO:0006749;sulfur compound catabolic process#GO:0044273;nitrogen compound metabolic process#GO:0006807;cellular modified amino acid metabolic process#GO:0006575;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG64858|UniProtKB=T1FY04 T1FY04 20213702 PTHR45948:SF2 DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0269404-RELATED DUAL SPECIFICITY PROTEIN PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;dephosphorylation#GO:0016311;biological regulation#GO:0065007;cellular metabolic process#GO:0044237;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052;phosphorus metabolic process#GO:0006793;metabolic process#GO:0008152;phosphate-containing compound metabolic process#GO:0006796 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG153321|UniProtKB=T1EL38 T1EL38 20197288 PTHR46289:SF17 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182854|UniProtKB=T1FIV3 T1FIV3 20208752 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG157055|UniProtKB=T1EM56 T1EM56 20197656 PTHR24637:SF388 COLLAGEN NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192230|UniProtKB=T1FTQ9 T1FTQ9 20212206 PTHR24064:SF577 SOLUTE CARRIER FAMILY 22 MEMBER GH09241P secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG94730|UniProtKB=T1G926 T1G926 20217573 PTHR24056:SF0 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 7 transferase activity#GO:0016740;cyclin-dependent protein kinase activity#GO:0097472;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;macromolecule modification#GO:0043412;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;protein modification process#GO:0036211;regulation of RNA biosynthetic process#GO:2001141;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;phosphorylation#GO:0016310;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;protein metabolic process#GO:0019538;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;regulation of DNA-templated transcription#GO:0006355;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;DNA-directed RNA polymerase complex#GO:0000428;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nucleoplasm#GO:0005654;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;serine/threonine protein kinase complex#GO:1902554;RNA polymerase II transcription regulator complex#GO:0090575;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;RNA polymerase II, holoenzyme#GO:0016591;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;transcription regulator complex#GO:0005667;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;transcription factor TFIIH holo complex#GO:0005675;nuclear protein-containing complex#GO:0140513 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG173437|UniProtKB=T1F6T7 T1F6T7 20204536 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-LIKE 1 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;localization#GO:0051179;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 membrane protein complex#GO:0098796;synapse#GO:0045202;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron projection#GO:0043005;transmembrane transporter complex#GO:1902495;cell projection#GO:0042995;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HELRO|EnsemblGenome=HelroG169280|UniProtKB=T1F1P9 T1F1P9 20202749 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED BRCT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177424|UniProtKB=T1FBN9 T1FBN9 20206238 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG91248|UniProtKB=T1G819 T1G819 20217216 PTHR13476:SF0 CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6 CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6 histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;protein-DNA complex#GO:0032993;chromatin#GO:0000785;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;chromosome#GO:0005694 HELRO|EnsemblGenome=HelroG190889|UniProtKB=T1FSE2 T1FSE2 20211739 PTHR10997:SF7 IMPORTIN-7, 8, 11 IMPORTIN-11 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;protein import into nucleus#GO:0006606;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;protein localization to organelle#GO:0033365;intracellular transport#GO:0046907;nuclear transport#GO:0051169;import into nucleus#GO:0051170 envelope#GO:0031975;cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG102242|UniProtKB=T1ED88 T1ED88 20194540 PTHR18916:SF6 DYNACTIN 1-RELATED MICROTUBULE-BINDING DYNACTIN SUBUNIT 1 chaperone#PC00072 Huntington disease#P00029>Dynactin#P00781 HELRO|EnsemblGenome=HelroG121944|UniProtKB=T1EGT2 T1EGT2 20195782 PTHR19297:SF181 GLYCOSYLTRANSFERASE 14 FAMILY MEMBER PROTEIN XYLOSYLTRANSFERASE acetylglucosaminyltransferase activity#GO:0008375;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG85729|UniProtKB=T1G624 T1G624 20216521 PTHR24270:SF61 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 apolipoprotein#PC00052 HELRO|EnsemblGenome=HelroG180337|UniProtKB=T1FFR9 T1FFR9 20207668 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG122541|UniProtKB=T1EGU9 T1EGU9 20195799 PTHR11767:SF102 INWARD RECTIFIER POTASSIUM CHANNEL INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of localization#GO:0032879;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;import across plasma membrane#GO:0098739;regulation of transport#GO:0051049;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;regulation of monoatomic ion transport#GO:0043269;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;potassium ion transport#GO:0006813;potassium ion import across plasma membrane#GO:1990573 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG173143|UniProtKB=T1F6G2 T1F6G2 20204411 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193020|UniProtKB=T1FUJ0 T1FUJ0 20212486 PTHR22050:SF0 RW1 PROTEIN HOMOLOG TRANSMEMBRANE PROTEIN 131 HOMOLOG cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG95514|UniProtKB=T1G965 T1G965 20217612 PTHR23119:SF51 DISCS LARGE DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN enzyme binding#GO:0019899;protein binding#GO:0005515;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900 establishment or maintenance of cell polarity#GO:0007163;localization within membrane#GO:0051668;cellular localization#GO:0051641;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;developmental process#GO:0032502;multicellular organism development#GO:0007275;cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987;protein localization#GO:0008104;localization#GO:0051179;embryo development#GO:0009790;cellular macromolecule localization#GO:0070727;anatomical structure development#GO:0048856;establishment or maintenance of apical/basal cell polarity#GO:0035088;multicellular organismal process#GO:0032501;receptor clustering#GO:0043113;establishment or maintenance of bipolar cell polarity#GO:0061245;protein-containing complex localization#GO:0031503 basal plasma membrane#GO:0009925;basolateral plasma membrane#GO:0016323;cell junction#GO:0030054;plasma membrane region#GO:0098590;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;basal part of cell#GO:0045178;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG191853|UniProtKB=T1FTC9 T1FTC9 20212076 PTHR11362:SF82 PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4 protease inhibitor#PC00191 EGF receptor signaling pathway#P00018>RKIP#P00548;FGF signaling pathway#P00021>RKIP#P00630 HELRO|EnsemblGenome=HelroG156722|UniProtKB=T1EM03 T1EM03 20197603 PTHR11071:SF561 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;catalytic activity#GO:0003824;peptide binding#GO:0042277;amide binding#GO:0033218 macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein peptidyl-prolyl isomerization#GO:0000413;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG189122|UniProtKB=T1FQP4 T1FQP4 20211141 PTHR11214:SF364 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE HEXOSYLTRANSFERASE transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG109943|UniProtKB=T1EEX6 T1EEX6 20195128 PTHR23064:SF72 TROPONIN TROPONIN C, SKELETAL MUSCLE cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG185300|UniProtKB=T1FMM8 T1FMM8 20210077 PTHR12976:SF0 RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE DELTA-SUBUNIT RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT DELTA cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG66728|UniProtKB=T1FYP6 T1FYP6 20213944 PTHR47023:SF1 SEX PEPTIDE RECEPTOR SEX PEPTIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG164327|UniProtKB=T1EV93 T1EV93 20200493 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG133869|UniProtKB=T1EI28 T1EI28 20196228 PTHR14379:SF3 LIMKAIN B LKAP MEIOSIS REGULATOR AND MRNA STABILITY FACTOR 1 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG176720|UniProtKB=T1FAT9 T1FAT9 20205938 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG75595|UniProtKB=T1G268 T1G268 20215166 PTHR11384:SF59 ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER LYSOSOMAL COBALAMIN TRANSPORTER ABCD4 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG164349|UniProtKB=T1EVA8 T1EVA8 20200508 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG88777|UniProtKB=T1G762 T1G762 20216909 PTHR11953:SF1 EXOSOME COMPLEX COMPONENT EXOSOME COMPLEX COMPONENT RRP46 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;regulation of biological process#GO:0050789;ncRNA metabolic process#GO:0034660;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;mRNA catabolic process#GO:0006402;snRNA 3'-end processing#GO:0034472;catabolic process#GO:0009056;snRNA processing#GO:0016180;RNA catabolic process#GO:0006401;regulation of macromolecule biosynthetic process#GO:0010556;organic substance catabolic process#GO:1901575;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;snRNA metabolic process#GO:0016073;macromolecule biosynthetic process#GO:0009059;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;negative regulation of metabolic process#GO:0009892;nuclear-transcribed mRNA catabolic process#GO:0000956;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;regulation of cellular biosynthetic process#GO:0031326;aromatic compound catabolic process#GO:0019439;regulation of macromolecule metabolic process#GO:0060255;rRNA metabolic process#GO:0016072;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;exosome (RNase complex)#GO:0000178;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;exoribonuclease#PC00099 HELRO|EnsemblGenome=HelroG95968|UniProtKB=T1G993 T1G993 20217640 PTHR11082:SF5 TRNA-DIHYDROURIDINE SYNTHASE TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor#GO:0016628 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG169565|UniProtKB=T1F238 T1F238 20202888 PTHR24096:SF149 LONG-CHAIN-FATTY-ACID--COA LIGASE AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED ligase activity#GO:0016874;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 metabolite interconversion enzyme#PC00262;ligase#PC00142 HELRO|EnsemblGenome=HelroG83027|UniProtKB=T1G4Z3 T1G4Z3 20216141 PTHR44147:SF2 DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 1 DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 1 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG159028|UniProtKB=T1ENI0 T1ENI0 20198130 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED single-stranded RNA binding#GO:0003727;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;poly(A) binding#GO:0008143;binding#GO:0005488;organic cyclic compound binding#GO:0097159 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG192108|UniProtKB=T1FTK8 T1FTK8 20212155 PTHR24416:SF483 TYROSINE-PROTEIN KINASE RECEPTOR HEPATOCYTE GROWTH FACTOR RECEPTOR signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG89719|UniProtKB=T1G7G4 T1G7G4 20217011 PTHR11267:SF196 T-BOX PROTEIN-RELATED T-BOX PROTEIN 30_42-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cell fate commitment#GO:0045165;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;cell fate specification#GO:0001708;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HELRO|EnsemblGenome=HelroG191375|UniProtKB=T1FSX7 T1FSX7 20211924 PTHR31164:SF1 RAD52 MOTIF-CONTAINING PROTEIN 1 RAD52 MOTIF-CONTAINING PROTEIN 1 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG153459|UniProtKB=T1EL76 T1EL76 20197326 PTHR33273:SF4 DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG65459|UniProtKB=T1FY80 T1FY80 20213778 PTHR21562:SF122 NOTUM-RELATED PALMITOLEOYL-PROTEIN CARBOXYLESTERASE NOTUM HELRO|EnsemblGenome=HelroG193315|UniProtKB=T1FUV5 T1FUV5 20212601 PTHR24256:SF470 TRYPTASE-RELATED INACTIVE CLIP DOMAIN-CONTAINING SERINE PROTEASE A30 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG91227|UniProtKB=T1G812 T1G812 20217209 PTHR10741:SF5 TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X TRANSLIN-ASSOCIATED PROTEIN X nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG91226|UniProtKB=T1G811 T1G811 20217208 PTHR10857:SF102 COPINE C2 DOMAIN-CONTAINING PROTEIN lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;cellular process#GO:0009987;response to chemical#GO:0042221 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG181791|UniProtKB=T1FHC1 T1FHC1 20208220 PTHR23233:SF84 SAL-LIKE PROTEIN FI23031P1 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG91813|UniProtKB=T1G895 T1G895 20217292 PTHR46167:SF1 N-LYSINE METHYLTRANSFERASE KMT5A N-LYSINE METHYLTRANSFERASE KMT5A N-methyltransferase activity#GO:0008170;histone modifying activity#GO:0140993;transferase activity#GO:0016740;catalytic activity#GO:0003824;histone methyltransferase activity#GO:0042054;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;protein-lysine N-methyltransferase activity#GO:0016279;catalytic activity, acting on a protein#GO:0140096;lysine N-methyltransferase activity#GO:0016278;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein methyltransferase activity#GO:0008276 regulation of cell communication#GO:0010646;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of signaling#GO:0023051;regulation of response to stress#GO:0080134;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of intracellular signal transduction#GO:1902531;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular response to stress#GO:0080135;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG86945|UniProtKB=T1G6J7 T1G6J7 20216694 PTHR45955:SF1 PHOSPHOACETYLGLUCOSAMINE MUTASE PHOSPHOACETYLGLUCOSAMINE MUTASE isomerase activity#GO:0016853;intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;carbohydrate derivative metabolic process#GO:1901135;UDP-N-acetylglucosamine metabolic process#GO:0006047;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleotide-sugar metabolic process#GO:0009225;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;amino sugar metabolic process#GO:0006040;aromatic compound biosynthetic process#GO:0019438;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 mutase#PC00160 HELRO|EnsemblGenome=HelroG86512|UniProtKB=T1G6D4 T1G6D4 20216631 PTHR45617:SF170 LEUCINE RICH REPEAT FAMILY PROTEIN MIP14966P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG169691|UniProtKB=T1F285 T1F285 20202935 PTHR21683:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG82104|UniProtKB=T1G4M8 T1G4M8 20216026 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG179484|UniProtKB=T1FES4 T1FES4 20207323 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG183537|UniProtKB=T1FJT4 T1FJT4 20209083 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG98103|UniProtKB=T1G9K7 T1G9K7 20217753 PTHR31108:SF1 TUMOR PROTEIN P63-REGULATED GENE 1-LIKE PROTEIN HSAC2 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158579|UniProtKB=T1EMY9 T1EMY9 20197939 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG81692|UniProtKB=T1G4H7 T1G4H7 20215975 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG175726|UniProtKB=T1F9K9 T1F9K9 20205508 PTHR12449:SF22 DEATH DOMAIN-CONTAINING PROTEIN NUCLEOLAR PROTEIN 4 HELRO|EnsemblGenome=HelroG180703|UniProtKB=T1FG69 T1FG69 20207818 PTHR14454:SF11 GRB2-ASSOCIATED AND REGULATOR OF MAPK PROTEIN FAMILY MEMBER SERRANO, ISOFORM F HELRO|EnsemblGenome=HelroG163413|UniProtKB=T1EU07 T1EU07 20200057 PTHR12243:SF69 MADF DOMAIN TRANSCRIPTION FACTOR SI:CH73-59F11.3 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG190273|UniProtKB=T1FRU6 T1FRU6 20211543 PTHR16266:SF17 WD REPEAT DOMAIN 9 BRWD3 regulation of anatomical structure morphogenesis#GO:0022603;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;cellular component organization#GO:0016043;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;regulation of cell shape#GO:0008360;regulation of cellular biosynthetic process#GO:0031326;regulation of biological quality#GO:0065008;regulation of macromolecule metabolic process#GO:0060255;regulation of developmental process#GO:0050793;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG193498|UniProtKB=T1FV21 T1FV21 20212667 PTHR42733:SF13 DJ-1 PROTEIN DJ-1_PFPI DOMAIN-CONTAINING PROTEIN cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG165255|UniProtKB=T1EWI2 T1EWI2 20200932 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162124|UniProtKB=T1ES95 T1ES95 20199445 PTHR45901:SF3 PROTEIN CBG12474 LIPOXYGENASE HOMOLOGY DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG175909|UniProtKB=T1F9V3 T1F9V3 20205602 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG144670|UniProtKB=T1EJF7 T1EJF7 20196707 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG179325|UniProtKB=T1FEJ8 T1FEJ8 20207247 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG82549|UniProtKB=T1G4T7 T1G4T7 20216085 PTHR13323:SF4 LATE ENDOSOMAL/LYSOSOMAL MP1 INTERACTING PROTEIN RAGULATOR COMPLEX PROTEIN LAMTOR2 positive regulation of signal transduction#GO:0009967;regulation of signaling#GO:0023051;cellular response to nitrogen compound#GO:1901699;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;positive regulation of response to stimulus#GO:0048584;cellular response to oxygen-containing compound#GO:1901701;response to endogenous stimulus#GO:0009719;positive regulation of TOR signaling#GO:0032008;regulation of signal transduction#GO:0009966;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;response to organic substance#GO:0010033;regulation of cell communication#GO:0010646;cellular response to stimulus#GO:0051716;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;cellular response to organic substance#GO:0071310;response to organonitrogen compound#GO:0010243;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;cellular response to organonitrogen compound#GO:0071417;positive regulation of cell communication#GO:0010647;biological regulation#GO:0065007 HELRO|EnsemblGenome=HelroG94423|UniProtKB=T1G911 T1G911 20217558 PTHR24343:SF457 SERINE/THREONINE KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG182208|UniProtKB=T1FHX5 T1FHX5 20208424 PTHR15208:SF2 RECEPTOR-BINDING CANCER ANTIGEN EXPRESSED ON SISO CELLS CANCER ASSOCIATED SURFACE ANTIGEN RCAS1 ESTROGEN RECEPTOR-BINDING FRAGMENT- ASSOCIATED GENE 9 PROTEIN RECEPTOR-BINDING CANCER ANTIGEN EXPRESSED ON SISO CELLS cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;secretory vesicle#GO:0099503;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG167418|UniProtKB=T1EZC2 T1EZC2 20201922 PTHR24027:SF422 CADHERIN-23 CADHERIN DOMAIN-CONTAINING PROTEIN cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;binding#GO:0005488;beta-catenin binding#GO:0008013 cellular component assembly#GO:0022607;cell-cell junction organization#GO:0045216;cellular component biogenesis#GO:0044085;cell-cell junction assembly#GO:0007043;developmental process#GO:0032502;multicellular organism development#GO:0007275;cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cell morphogenesis#GO:0000902;cell motility#GO:0048870;cell adhesion#GO:0007155;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;cell junction organization#GO:0034330;cell junction assembly#GO:0034329;multicellular organismal process#GO:0032501;cell migration#GO:0016477;adherens junction organization#GO:0034332 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;anchoring junction#GO:0070161;cell-cell junction#GO:0005911;plasma membrane protein complex#GO:0098797;cell junction#GO:0030054;adherens junction#GO:0005912;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886;extrinsic component of membrane#GO:0019898 cadherin#PC00057 HELRO|EnsemblGenome=HelroG153940|UniProtKB=T1ELD2 T1ELD2 20197382 PTHR16705:SF4 COMPLEXIN COMPLEXIN protein binding#GO:0005515;binding#GO:0005488;SNARE binding#GO:0000149 SNARE complex#GO:0031201;cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG173174|UniProtKB=T1F6I4 T1F6I4 20204433 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77646|UniProtKB=T1G315 T1G315 20215463 PTHR11361:SF21 DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER MUTS PROTEIN HOMOLOG 4 nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 cellular aromatic compound metabolic process#GO:0006725;nuclear division#GO:0000280;cell cycle process#GO:0022402;nucleobase-containing compound metabolic process#GO:0006139;reciprocal homologous recombination#GO:0140527;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;meiotic cell cycle process#GO:1903046;meiosis I cell cycle process#GO:0061982;reciprocal meiotic recombination#GO:0007131;reproductive process#GO:0022414;meiosis I#GO:0007127;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule metabolic process#GO:0043170;meiotic cell cycle#GO:0051321;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;reproduction#GO:0000003;organelle organization#GO:0006996;meiotic nuclear division#GO:0140013;sexual reproduction#GO:0019953;organelle fission#GO:0048285;cell cycle#GO:0007049;homologous recombination#GO:0035825;DNA metabolic process#GO:0006259 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG64253|UniProtKB=T1FXR8 T1FXR8 20213616 PTHR10157:SF29 DOPAMINE BETA HYDROXYLASE RELATED DOPAMINE BETA-HYDROXYLASE cation binding#GO:0043169;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;copper ion binding#GO:0005507;metal ion binding#GO:0046872;ion binding#GO:0043167;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497 organic hydroxy compound metabolic process#GO:1901615;cellular aromatic compound metabolic process#GO:0006725;amine metabolic process#GO:0009308;alcohol biosynthetic process#GO:0046165;biogenic amine metabolic process#GO:0006576;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;alcohol metabolic process#GO:0006066;organic hydroxy compound biosynthetic process#GO:1901617;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;catecholamine metabolic process#GO:0006584;biosynthetic process#GO:0009058;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;organic cyclic compound metabolic process#GO:1901360;aromatic compound catabolic process#GO:0019439;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;organic cyclic compound catabolic process#GO:1901361;catabolic process#GO:0009056;aromatic compound biosynthetic process#GO:0019438;small molecule biosynthetic process#GO:0044283;organic substance catabolic process#GO:1901575;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152 bounding membrane of organelle#GO:0098588;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;secretory granule membrane#GO:0030667;extracellular region#GO:0005576;secretory granule#GO:0030141;organelle membrane#GO:0031090;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;vesicle membrane#GO:0012506;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cytoplasmic vesicle membrane#GO:0030659;secretory vesicle#GO:0099503 hydroxylase#PC00122 Adrenaline and noradrenaline biosynthesis#P00001>DBH#P00063;Dopamine receptor mediated signaling pathway#P05912>DBH#P05955 HELRO|EnsemblGenome=HelroG92073|UniProtKB=T1G8B9 T1G8B9 20217316 PTHR12245:SF11 SPRY DOMAIN CONTAINING SOCS BOX PROTEIN PROTEIN GUSTAVUS macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG162954|UniProtKB=T1ETF0 T1ETF0 20199850 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG68039|UniProtKB=T1FZ94 T1FZ94 20214142 PTHR13563:SF5 TRNA (GUANINE-9-) METHYLTRANSFERASE TRNA METHYLTRANSFERASE 10 HOMOLOG C tRNA binding#GO:0000049;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159 positive regulation of gene expression#GO:0010628;cellular aromatic compound metabolic process#GO:0006725;positive regulation of nitrogen compound metabolic process#GO:0051173;tRNA metabolic process#GO:0006399;regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;macromolecule modification#GO:0043412;regulation of nitrogen compound metabolic process#GO:0051171;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;positive regulation of cellular metabolic process#GO:0031325;mitochondrial gene expression#GO:0140053;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;ncRNA metabolic process#GO:0034660;tRNA methylation#GO:0030488;organic cyclic compound metabolic process#GO:1901360;positive regulation of metabolic process#GO:0009893;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;positive regulation of translation#GO:0045727;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;mitochondrial RNA metabolic process#GO:0000959;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;positive regulation of cellular biosynthetic process#GO:0031328;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;mitochondrial RNA processing#GO:0000963;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;positive regulation of protein metabolic process#GO:0051247;nucleic acid metabolic process#GO:0090304;macromolecule methylation#GO:0043414;regulation of cellular biosynthetic process#GO:0031326;methylation#GO:0032259;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of translation#GO:0006417;RNA methylation#GO:0001510;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG166122|UniProtKB=T1EXT4 T1EXT4 20201384 PTHR33590:SF1 GLUTENIN, HIGH MOLECULAR WEIGHT SUBUNIT PW212-RELATED PROTEIN PDZ DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173557|UniProtKB=T1F6Z0 T1F6Z0 20204589 PTHR22902:SF9 SESQUIPEDALIAN PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY J MEMBER 1 endosomal transport#GO:0016197;cellular localization#GO:0051641;macromolecule metabolic process#GO:0043170;transport#GO:0006810;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;endosome organization#GO:0007032;establishment of localization#GO:0051234;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;vesicle organization#GO:0016050;intracellular transport#GO:0046907;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 trans-Golgi network#GO:0005802;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;early endosome#GO:0005769;organelle subcompartment#GO:0031984;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;recycling endosome#GO:0055037;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG162255|UniProtKB=T1ESF3 T1ESF3 20199503 PTHR11841:SF1 REELIN REELIN extracellular matrix glycoprotein#PC00100;extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG164206|UniProtKB=T1EV35 T1EV35 20200435 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG107894|UniProtKB=T1EED7 T1EED7 20194939 PTHR47992:SF63 PROTEIN PHOSPHATASE ALPHABET, ISOFORM E protein phosphatase#PC00195;protein modifying enzyme#PC00260 DPP-SCW signaling pathway#P06212>PPM1A#P06261;Activin beta signaling pathway#P06210>PPM1A#P06237;MYO signaling pathway#P06215>PPM1A#P06317;BMP/activin signaling pathway-drosophila#P06211>PPM1A#P06247;ALP23B signaling pathway#P06209>PPM1A#P06226;GBB signaling pathway#P06214>PPM1A#P06296;DPP signaling pathway#P06213>PPM1A#P06289;SCW signaling pathway#P06216>PPM1A#P06332 HELRO|EnsemblGenome=HelroG159354|UniProtKB=T1ENX5 T1ENX5 20198275 PTHR46061:SF3 THYROTROPIN-RELEASING HORMONE RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 Thyrotropin-releasing hormone receptor signaling pathway#P04394>TRH Receptor#P04580 HELRO|EnsemblGenome=HelroG164780|UniProtKB=T1EVT1 T1EVT1 20200681 PTHR12390:SF0 UROPORPHYRINOGEN III SYNTHASE UROPORPHYRINOGEN-III SYNTHASE lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 tetrapyrrole metabolic process#GO:0033013;cellular aromatic compound metabolic process#GO:0006725;organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;porphyrin-containing compound metabolic process#GO:0006778;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;carboxylic acid biosynthetic process#GO:0046394;heterocycle biosynthetic process#GO:0018130;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;small molecule biosynthetic process#GO:0044283;carboxylic acid metabolic process#GO:0019752;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 hydrolase#PC00121 Heme biosynthesis#P02746>Uroporphyrinogen-III synthase#P02974 HELRO|EnsemblGenome=HelroG181843|UniProtKB=T1FHE2 T1FHE2 20208241 PTHR12514:SF1 ENHANCER OF YELLOW 2 TRANSCRIPTION FACTOR TRANSCRIPTION AND MRNA EXPORT FACTOR ENY2 molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;chromatin binding#GO:0003682;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;protein-containing complex binding#GO:0044877 cellular localization#GO:0051641;macromolecule localization#GO:0033036;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;regulation of RNA biosynthetic process#GO:2001141;biosynthetic process#GO:0009058;RNA localization#GO:0006403;regulation of biological process#GO:0050789;organic substance transport#GO:0071702;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;RNA transport#GO:0050658;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;poly(A)+ mRNA export from nucleus#GO:0016973;mRNA export from nucleus#GO:0006406;macromolecule biosynthetic process#GO:0009059;establishment of RNA localization#GO:0051236;regulation of DNA-templated transcription#GO:0006355;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;mRNA transport#GO:0051028;regulation of RNA metabolic process#GO:0051252;localization#GO:0051179;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;nuclear export#GO:0051168;regulation of macromolecule metabolic process#GO:0060255;nucleocytoplasmic transport#GO:0006913;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleobase-containing compound transport#GO:0015931;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 SAGA-type complex#GO:0070461;peptidase complex#GO:1905368;histone acetyltransferase complex#GO:0000123;nucleus#GO:0005634;acetyltransferase complex#GO:1902493;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;chromatin#GO:0000785;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;chromosome#GO:0005694;SAGA complex#GO:0000124;membrane-bounded organelle#GO:0043227;DUBm complex#GO:0071819;nuclear protein-containing complex#GO:0140513 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG182594|UniProtKB=T1FIF6 T1FIF6 20208605 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163815|UniProtKB=T1EUI2 T1EUI2 20200232 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173520|UniProtKB=T1F6X5 T1F6X5 20204574 PTHR15021:SF0 DISCONNECTED-RELATED DISCO-RELATED, ISOFORM A-RELATED regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG189214|UniProtKB=T1FQS9 T1FQS9 20211176 PTHR10098:SF108 RAPSYN-RELATED TETRATRICOPEPTIDE REPEAT PROTEIN 28 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG147095|UniProtKB=T1EJW8 T1EJW8 20196868 PTHR11954:SF22 D-DOPACHROME DECARBOXYLASE D-DOPACHROME DECARBOXYLASE isomerase activity#GO:0016853;catalytic activity#GO:0003824 extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 decarboxylase#PC00089;lyase#PC00144 HELRO|EnsemblGenome=HelroG185792|UniProtKB=T1FNA5 T1FNA5 20210302 PTHR11246:SF3 PRE-MRNA SPLICING FACTOR CROOKED NECK-LIKE PROTEIN 1 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;mRNA splicing, via spliceosome#GO:0000398;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375;spliceosomal complex assembly#GO:0000245 catalytic step 2 spliceosome#GO:0071013;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;U2-type spliceosomal complex#GO:0005684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;post-mRNA release spliceosomal complex#GO:0071014;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;precatalytic spliceosome#GO:0071011;membrane-bounded organelle#GO:0043227;Prp19 complex#GO:0000974;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG178673|UniProtKB=T1FDJ8 T1FDJ8 20206897 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG91240|UniProtKB=T1G815 T1G815 20217212 PTHR10584:SF166 SUGAR KINASE RIBOKINASE transferase#PC00220;metabolite interconversion enzyme#PC00262;carbohydrate kinase#PC00065 HELRO|EnsemblGenome=HelroG151021|UniProtKB=T1EKI3 T1EKI3 20197083 PTHR11599:SF12 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT ALPHA TYPE-1 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 peptidase complex#GO:1905368;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;proteasome complex#GO:0000502;endopeptidase complex#GO:1905369;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 protease#PC00190;protein modifying enzyme#PC00260 Parkinson disease#P00049>20S proteasome#P01227 HELRO|EnsemblGenome=HelroG193937|UniProtKB=T1FVH7 T1FVH7 20212823 PTHR12280:SF20 PANTOTHENATE KINASE 4'-PHOSPHOPANTETHEINE PHOSPHATASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 kinase#PC00137 Coenzyme A biosynthesis#P02736>Pantothenate kinase#P02885 HELRO|EnsemblGenome=HelroG192032|UniProtKB=T1FTI8 T1FTI8 20212135 PTHR12814:SF2 RNA-BINDING PROTEIN NOB1 RNA-BINDING PROTEIN NOB1 catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 preribosome, small subunit precursor#GO:0030688;ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG184939|UniProtKB=T1FM68 T1FM68 20209917 PTHR19282:SF431 TETRASPANIN TETRASPANIN 26A, ISOFORM B-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG69115|UniProtKB=T1FZP7 T1FZP7 20214295 PTHR21242:SF0 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10 protein-containing complex binding#GO:0044877;chromatin binding#GO:0003682;binding#GO:0005488 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;DNA-templated transcription#GO:0006351;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;transcription initiation at RNA polymerase II promoter#GO:0006367;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 histone acetyltransferase complex#GO:0000123;DNA-directed RNA polymerase complex#GO:0000428;acetyltransferase complex#GO:1902493;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase II, holoenzyme#GO:0016591;non-membrane-bounded organelle#GO:0043228;chromosome#GO:0005694;nuclear DNA-directed RNA polymerase complex#GO:0055029;SAGA complex#GO:0000124;membrane-enclosed lumen#GO:0031974;SAGA-type complex#GO:0070461;peptidase complex#GO:1905368;organelle lumen#GO:0043233;nucleus#GO:0005634;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;protein-DNA complex#GO:0032993;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;RNA polymerase II transcription regulator complex#GO:0090575;transcription factor TFIID complex#GO:0005669;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;protein acetyltransferase complex#GO:0031248;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG166151|UniProtKB=T1EXU5 T1EXU5 20201395 PTHR19316:SF18 PROTEIN FOLDING REGULATOR HSP70-BINDING PROTEIN 1 nucleoside phosphate binding#GO:1901265;nucleotide binding#GO:0000166;heterocyclic compound binding#GO:1901363;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;molecular function regulator activity#GO:0098772 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG193942|UniProtKB=T1FVI2 T1FVI2 20212828 PTHR23208:SF36 LYSOZYME PROTEIN LYSOZYME-RELATED metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG91264|UniProtKB=T1G821 T1G821 20217218 PTHR11537:SF113 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;delayed rectifier potassium channel activity#GO:0005251;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG109698|UniProtKB=T1EEV8 T1EEV8 20195110 PTHR24340:SF41 HOMEOBOX PROTEIN NKX MUSCLE-SPECIFIC HOMEOBOX PROTEIN TINMAN-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG172119|UniProtKB=T1F518 T1F518 20203917 PTHR14663:SF2 METHYLTRANSFERASE NSUN7-RELATED METHYLTRANSFERASE NSUN7-RELATED HELRO|EnsemblGenome=HelroG172863|UniProtKB=T1F614 T1F614 20204263 PTHR24388:SF104 ZINC FINGER PROTEIN AT-RICH BINDING PROTEIN-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG111539|UniProtKB=T1EFC2 T1EFC2 20195274 PTHR10617:SF107 ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL electron transfer activity#GO:0009055;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cellular metabolic process#GO:0044237;electron transport chain#GO:0022900;cellular process#GO:0009987;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG90503|UniProtKB=T1G7S4 T1G7S4 20217121 PTHR43520:SF8 ATP7, ISOFORM B P-TYPE CU(+) TRANSPORTER inorganic molecular entity transmembrane transporter activity#GO:0015318;small molecule binding#GO:0036094;binding#GO:0005488;transition metal ion binding#GO:0046914;copper ion binding#GO:0005507;metal ion binding#GO:0046872;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;P-type ion transporter activity#GO:0015662;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;cation binding#GO:0043169;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;ion binding#GO:0043167;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075 monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;monoatomic ion homeostasis#GO:0050801 cellular anatomical entity#GO:0110165;membrane#GO:0016020 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG194518|UniProtKB=T1FW55 T1FW55 20213051 PTHR14217:SF1 INOSITOL-TETRAKISPHOSPHATE 1-KINASE INOSITOL-TETRAKISPHOSPHATE 1-KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 transferase#PC00220;kinase#PC00137;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG76233|UniProtKB=T1G2H0 T1G2H0 20215268 PTHR22977:SF1 COX ASSEMBLY MITOCHONDRIAL PROTEIN COX ASSEMBLY MITOCHONDRIAL PROTEIN 2 HOMOLOG cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG169427|UniProtKB=T1F1X1 T1F1X1 20202821 PTHR11849:SF304 ETS DNA-BINDING PROTEIN D-ETS-3 transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG173166|UniProtKB=T1F6H7 T1F6H7 20204426 PTHR32059:SF0 RAB11-BINDING PROTEIN RELCH RAB11-BINDING PROTEIN RELCH trans-Golgi network#GO:0005802;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;organelle subcompartment#GO:0031984;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;recycling endosome#GO:0055037;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791 HELRO|EnsemblGenome=HelroG113295|UniProtKB=T1EFR5 T1EFR5 20195417 PTHR13848:SF56 PROTEIN YIPPEE-LIKE CG15309-RELATED PROTEIN YIPPEE-LIKE 5 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG94015|UniProtKB=T1G8Y5 T1G8Y5 20217532 PTHR43979:SF1 PRE-MRNA-PROCESSING FACTOR 17 PRE-MRNA-PROCESSING FACTOR 17 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;catalytic step 2 spliceosome#GO:0071013;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG185016|UniProtKB=T1FMA1 T1FMA1 20209950 PTHR12439:SF11 PLACENTAL PROTEIN 11-RELATED URIDYLATE-SPECIFIC ENDORIBONUCLEASE HELRO|EnsemblGenome=HelroG192608|UniProtKB=T1FU45 T1FU45 20212341 PTHR10218:SF227 GTP-BINDING PROTEIN ALPHA SUBUNIT G PROTEIN ALPHA I SUBUNIT GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;ribonucleoside triphosphate phosphatase activity#GO:0017111;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 regulation of biological process#GO:0050789;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;side of membrane#GO:0098552;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;extrinsic component of membrane#GO:0019898 heterotrimeric G-protein#PC00117;G-protein#PC00020 Enkephalin release#P05913>G-Protein (i)#P05974;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Gialpha#P00712;Opioid proenkephalin pathway#P05915>G-protein#P05994;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;Opioid prodynorphin pathway#P05916>G-protein#P06002;PI3 kinase pathway#P00048>Galpha#P01199;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047 HELRO|EnsemblGenome=HelroG106760|UniProtKB=T1EE47 T1EE47 20194849 PTHR12356:SF3 NUCLEAR MOVEMENT PROTEIN NUDC NUCLEAR MIGRATION PROTEIN NUDC protein binding#GO:0005515;unfolded protein binding#GO:0051082;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG188063|UniProtKB=T1FPL3 T1FPL3 20210760 PTHR17695:SF11 SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG membrane-enclosed lumen#GO:0031974;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981;90S preribosome#GO:0030686 HELRO|EnsemblGenome=HelroG164257|UniProtKB=T1EV62 T1EV62 20200462 PTHR23151:SF90 DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED transferase#PC00220;acetyltransferase#PC00038;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG178270|UniProtKB=T1FD06 T1FD06 20206705 PTHR11902:SF1 ENOLASE ENOLASE lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;ribonucleoside triphosphate metabolic process#GO:0009199;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative metabolic process#GO:1901135;heterocycle catabolic process#GO:0046700;organonitrogen compound catabolic process#GO:1901565;ribonucleotide catabolic process#GO:0009261;pyridine nucleotide metabolic process#GO:0019362;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;cellular nitrogen compound catabolic process#GO:0044270;purine-containing compound catabolic process#GO:0072523;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;purine nucleotide catabolic process#GO:0006195;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;purine ribonucleotide catabolic process#GO:0009154;nucleoside phosphate metabolic process#GO:0006753;carbohydrate catabolic process#GO:0016052;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;catabolic process#GO:0009056;nucleoside diphosphate metabolic process#GO:0009132;organic substance catabolic process#GO:1901575;carbohydrate metabolic process#GO:0005975;purine nucleotide metabolic process#GO:0006163;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;oxoacid metabolic process#GO:0043436;nucleoside phosphate catabolic process#GO:1901292;carbohydrate derivative catabolic process#GO:1901136;purine ribonucleoside triphosphate metabolic process#GO:0009205;generation of precursor metabolites and energy#GO:0006091;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;nucleotide catabolic process#GO:0009166;cellular nitrogen compound metabolic process#GO:0034641;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;nucleoside diphosphate catabolic process#GO:0009134;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;organophosphate catabolic process#GO:0046434;aromatic compound catabolic process#GO:0019439;glycolytic process#GO:0006096;organic cyclic compound catabolic process#GO:1901361;organophosphate metabolic process#GO:0019637;purine nucleoside triphosphate metabolic process#GO:0009144;nucleobase-containing compound catabolic process#GO:0034655;nucleotide metabolic process#GO:0009117;carboxylic acid metabolic process#GO:0019752;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 lyase#PC00144 Glycolysis#P00024>Enolase#P00678 HELRO|EnsemblGenome=HelroG194170|UniProtKB=T1FVS0 T1FVS0 20212916 PTHR19282:SF431 TETRASPANIN TETRASPANIN 26A, ISOFORM B-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG163662|UniProtKB=T1EUB9 T1EUB9 20200169 PTHR19282:SF534 TETRASPANIN TETRASPANIN FAMILY-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG88144|UniProtKB=T1G6Z1 T1G6Z1 20216838 PTHR10603:SF7 FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN FRAGILE X MESSENGER RIBONUCLEOPROTEIN 1 HOMOLOG RNA binding#GO:0003723;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159;mRNA 3'-UTR binding#GO:0003730 positive regulation of gene expression#GO:0010628;positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;regulation of mRNA stability#GO:0043488;regulation of mRNA catabolic process#GO:0061013;regulation of catabolic process#GO:0009894;macromolecule localization#GO:0033036;regulation of nitrogen compound metabolic process#GO:0051171;animal organ development#GO:0048513;positive regulation of cellular metabolic process#GO:0031325;transport#GO:0006810;developmental process#GO:0032502;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;RNA localization#GO:0006403;regulation of biological process#GO:0050789;organic substance transport#GO:0071702;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;RNA transport#GO:0050658;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;positive regulation of translation#GO:0045727;establishment of RNA localization#GO:0051236;positive regulation of cellular biosynthetic process#GO:0031328;regulation of cellular catabolic process#GO:0031329;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;mRNA transport#GO:0051028;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;localization#GO:0051179;regulation of primary metabolic process#GO:0080090;positive regulation of protein metabolic process#GO:0051247;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleobase-containing compound transport#GO:0015931;post-transcriptional regulation of gene expression#GO:0010608;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of metabolic process#GO:0019222;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytoplasmic stress granule#GO:0010494;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic ribonucleoprotein granule#GO:0036464 translation factor#PC00223 HELRO|EnsemblGenome=HelroG175017|UniProtKB=T1F8Q6 T1F8Q6 20205205 PTHR11760:SF32 30S/40S RIBOSOMAL PROTEIN S3 SMALL RIBOSOMAL SUBUNIT PROTEIN US3 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;small ribosomal subunit#GO:0015935;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG174957|UniProtKB=T1F8N4 T1F8N4 20205183 PTHR31802:SF31 32 KDA HEAT SHOCK PROTEIN-RELATED MSR-110, ISOFORM C intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG77257|UniProtKB=T1G2V1 T1G2V1 20215399 PTHR45689:SF5 I[[H]] CHANNEL, ISOFORM E I[[H]] CHANNEL, ISOFORM E monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;sodium ion transport#GO:0006814;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;regulation of membrane depolarization#GO:0003254;sodium ion transmembrane transport#GO:0035725;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG80026|UniProtKB=T1G3W7 T1G3W7 20215765 PTHR24056:SF246 CELL DIVISION PROTEIN KINASE ECDYSONE-INDUCED PROTEIN 63E, ISOFORM N cyclin-dependent protein kinase activity#GO:0097472;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG111854|UniProtKB=T1EFF1 T1EFF1 20195303 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG194103|UniProtKB=T1FVP1 T1FVP1 20212887 PTHR10924:SF27 MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED SOLUTE CARRIER FAMILY 49 MEMBER 4 cellular anatomical entity#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG150377|UniProtKB=T1EKF3 T1EKF3 20197053 PTHR13780:SF35 AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT LD22662P kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG185617|UniProtKB=T1FN17 T1FN17 20210216 PTHR24250:SF27 CHYMOTRYPSIN-RELATED ELASTASE 2 LIKE hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG185132|UniProtKB=T1FMF7 T1FMF7 20210006 PTHR10404:SF77 N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;carboxypeptidase activity#GO:0004180 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG79776|UniProtKB=T1G3T1 T1G3T1 20215729 PTHR24637:SF377 COLLAGEN COLLAGEN TYPE IX ALPHA 1 CHAIN HELRO|EnsemblGenome=HelroG189807|UniProtKB=T1FRD7 T1FRD7 20211384 PTHR10292:SF1 CLATHRIN HEAVY CHAIN RELATED CLATHRIN HEAVY CHAIN protein binding#GO:0005515;clathrin binding#GO:0030276;binding#GO:0005488 localization#GO:0051179;establishment of localization#GO:0051234;transport#GO:0006810;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;receptor-mediated endocytosis#GO:0006898;cellular process#GO:0009987;import into cell#GO:0098657 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;membrane coat#GO:0030117;coated membrane#GO:0048475;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 vesicle coat protein#PC00235 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Clathrin#P00738;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Clathrin#P00722 HELRO|EnsemblGenome=HelroG189328|UniProtKB=T1FQY7 T1FQY7 20211234 PTHR19325:SF575 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING LOCOMOTION-RELATED PROTEIN HIKARU GENKI complement component#PC00078 HELRO|EnsemblGenome=HelroG153371|UniProtKB=T1EL54 T1EL54 20197304 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG142985|UniProtKB=T1EJ83 T1EJ83 20196633 PTHR45902:SF1 LATROPHILIN RECEPTOR-LIKE PROTEIN A LATROPHILIN RECEPTOR-LIKE PROTEIN A transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG100540|UniProtKB=T1ED03 T1ED03 20194455 PTHR24256:SF470 TRYPTASE-RELATED INACTIVE CLIP DOMAIN-CONTAINING SERINE PROTEASE A30 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG71907|UniProtKB=T1G0S9 T1G0S9 20214677 PTHR13073:SF0 BLOC-1 COMPLEX SUBUNIT 1 BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 1 localization#GO:0051179;endosomal transport#GO:0016197;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;cellular process#GO:0009987 protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG166565|UniProtKB=T1EY93 T1EY93 20201543 PTHR22763:SF162 RING ZINC FINGER PROTEIN TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG78775|UniProtKB=T1G3F6 T1G3F6 20215604 PTHR19321:SF41 PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED FASCETTO-RELATED cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule-based process#GO:0007017;organelle organization#GO:0006996 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;spindle#GO:0005819;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG190926|UniProtKB=T1FSF4 T1FSF4 20211751 PTHR13268:SF0 BREAST CARCINOMA AMPLIFIED SEQUENCE 3 BCAS3 MICROTUBULE ASSOCIATED CELL MIGRATION FACTOR response to stimulus#GO:0050896;response to external stimulus#GO:0009605;response to nutrient levels#GO:0031667;response to stress#GO:0006950;response to extracellular stimulus#GO:0009991;response to starvation#GO:0042594 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG183747|UniProtKB=T1FK48 T1FK48 20209197 PTHR24020:SF84 COLLAGEN ALPHA VWFA DOMAIN-CONTAINING PROTEIN extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG169968|UniProtKB=T1F2H7 T1F2H7 20203027 PTHR14555:SF3 MYELIN-ASSOCIATED OLIGODENDROCYTIC BASIC PROTEIN MOBP -RELATED RABBD DOMAIN-CONTAINING PROTEIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;myosin binding#GO:0017022;actin binding#GO:0003779;binding#GO:0005488 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;cell cortex#GO:0005938;cell periphery#GO:0071944;cortical actin cytoskeleton#GO:0030864;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 myelin protein#PC00161;structural protein#PC00211 HELRO|EnsemblGenome=HelroG173658|UniProtKB=T1F732 T1F732 20204631 PTHR11339:SF395 EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED GH18 DOMAIN-CONTAINING PROTEIN extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG83731|UniProtKB=T1G598 T1G598 20216245 PTHR24031:SF706 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX27-RELATED intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG65423|UniProtKB=T1FY76 T1FY76 20213774 PTHR47958:SF11 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE DDX4-RELATED catalytic activity, acting on RNA#GO:0140098;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640;mRNA binding#GO:0003729 germ cell development#GO:0007281;cellular developmental process#GO:0048869;gamete generation#GO:0007276;cellular process involved in reproduction in multicellular organism#GO:0022412;multicellular organism reproduction#GO:0032504;developmental process#GO:0032502;cellular process#GO:0009987;cell development#GO:0048468;developmental process involved in reproduction#GO:0003006;cell differentiation#GO:0030154;reproduction#GO:0000003;anatomical structure development#GO:0048856;sexual reproduction#GO:0019953;reproductive process#GO:0022414;multicellular organismal process#GO:0032501;multicellular organismal reproductive process#GO:0048609 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;P granule#GO:0043186;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG179230|UniProtKB=T1FEE2 T1FEE2 20207191 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG158830|UniProtKB=T1ENB4 T1ENB4 20198064 PTHR19303:SF71 TRANSPOSON ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG80042|UniProtKB=T1G3W8 T1G3W8 20215766 PTHR15427:SF33 EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG113018|UniProtKB=T1EFP6 T1EFP6 20195398 PTHR11106:SF27 GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED MACRO DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG116969|UniProtKB=T1EGI9 T1EGI9 20195691 PTHR12450:SF22 DENTIN MATRIX PROTEIN 4 PROTEIN FAM20 EXTRACELLULAR SERINE_THREONINE PROTEIN CG31145 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG191292|UniProtKB=T1FSU8 T1FSU8 20211895 PTHR23257:SF706 SERINE-THREONINE PROTEIN KINASE PROTO-ONCOGENE SERINE_THREONINE-PROTEIN KINASE MOS transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG73702|UniProtKB=T1G1H4 T1G1H4 20214922 PTHR43330:SF7 METHIONINE AMINOPEPTIDASE METHIONINE AMINOPEPTIDASE 1 metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;aminopeptidase activity#GO:0004177;exopeptidase activity#GO:0008238;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;metalloaminopeptidase activity#GO:0070006 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG182059|UniProtKB=T1FHP1 T1FHP1 20208340 PTHR19282:SF456 TETRASPANIN CD63 MOLECULE cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG74446|UniProtKB=T1G1R2 T1G1R2 20215010 PTHR23257:SF981 SERINE-THREONINE PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG109714|UniProtKB=T1EEV9 T1EEV9 20195111 PTHR22847:SF637 WD40 REPEAT PROTEIN WD REPEAT DOMAIN 5B HELRO|EnsemblGenome=HelroG167830|UniProtKB=T1EZU7 T1EZU7 20202097 PTHR47013:SF1 SPLICING FACTOR, ARGININE/SERINE-RICH 19 SPLICING FACTOR, ARGININE_SERINE-RICH 19 basal RNA polymerase II transcription machinery binding#GO:0001099;RNA polymerase binding#GO:0070063;binding#GO:0005488;RNA polymerase core enzyme binding#GO:0043175;RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515;enzyme binding#GO:0019899;basal transcription machinery binding#GO:0001098 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG175638|UniProtKB=T1F9G2 T1F9G2 20205461 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG84698|UniProtKB=T1G5M4 T1G5M4 20216371 PTHR36911:SF1 LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN-RELATED LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG100131|UniProtKB=T1ECY8 T1ECY8 20194440 PTHR23308:SF28 NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1 NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE 1 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG181485|UniProtKB=T1FH19 T1FH19 20208118 PTHR12363:SF33 TRANSPORTIN 3 AND IMPORTIN 13 IMPORTIN-13 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;protein import into nucleus#GO:0006606;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365;nuclear transport#GO:0051169;import into nucleus#GO:0051170 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG185579|UniProtKB=T1FN01 T1FN01 20210200 PTHR15184:SF71 ATP SYNTHASE ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 ATP synthesis#P02721>F1 beta#P02794 HELRO|EnsemblGenome=HelroG82787|UniProtKB=T1G4W7 T1G4W7 20216115 PTHR24078:SF519 DNAJ HOMOLOG SUBFAMILY C MEMBER DNAJ HOMOLOG SUBFAMILY B MEMBER 13 protein binding#GO:0005515;protein-folding chaperone binding#GO:0051087;unfolded protein binding#GO:0051082;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;chaperone-mediated protein folding#GO:0061077;chaperone cofactor-dependent protein refolding#GO:0051085;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;'de novo' protein folding#GO:0006458;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG190074|UniProtKB=T1FRN5 T1FRN5 20211482 PTHR16184:SF6 ELONGATOR COMPLEX PROTEIN 6 ELONGATOR COMPLEX PROTEIN 6 elongator holoenzyme complex#GO:0033588;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;catalytic complex#GO:1902494 HELRO|EnsemblGenome=HelroG186484|UniProtKB=T1FP00 T1FP00 20210547 PTHR10766:SF176 TRANSMEMBRANE 9 SUPERFAMILY PROTEIN TRANSMEMBRANE 9 SUPERFAMILY MEMBER localization#GO:0051179;localization within membrane#GO:0051668;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;cellular process#GO:0009987;protein localization#GO:0008104 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG166877|UniProtKB=T1EYP3 T1EYP3 20201693 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180750|UniProtKB=T1FG85 T1FG85 20207834 PTHR10293:SF73 GLUTAREDOXIN FAMILY MEMBER GLUTAREDOXIN-3 inorganic ion homeostasis#GO:0098771;intracellular iron ion homeostasis#GO:0006879;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;chemical homeostasis#GO:0048878;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 reductase#PC00198;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG64830|UniProtKB=T1FY00 T1FY00 20213698 PTHR24126:SF14 ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED ANK_REP_REGION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193940|UniProtKB=T1FVI0 T1FVI0 20212826 PTHR12280:SF20 PANTOTHENATE KINASE 4'-PHOSPHOPANTETHEINE PHOSPHATASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 kinase#PC00137 Coenzyme A biosynthesis#P02736>Pantothenate kinase#P02885 HELRO|EnsemblGenome=HelroG173726|UniProtKB=T1F761 T1F761 20204660 PTHR14625:SF3 MICROCEPHALIN MICROCEPHALIN cell cycle#GO:0007049;mitotic cell cycle#GO:0000278;cellular process#GO:0009987 damaged DNA-binding protein#PC00086;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG157743|UniProtKB=T1EMF3 T1EMF3 20197753 PTHR47992:SF63 PROTEIN PHOSPHATASE ALPHABET, ISOFORM E protein phosphatase#PC00195;protein modifying enzyme#PC00260 DPP-SCW signaling pathway#P06212>PPM1A#P06261;Activin beta signaling pathway#P06210>PPM1A#P06237;MYO signaling pathway#P06215>PPM1A#P06317;BMP/activin signaling pathway-drosophila#P06211>PPM1A#P06247;ALP23B signaling pathway#P06209>PPM1A#P06226;GBB signaling pathway#P06214>PPM1A#P06296;DPP signaling pathway#P06213>PPM1A#P06289;SCW signaling pathway#P06216>PPM1A#P06332 HELRO|EnsemblGenome=HelroG79045|UniProtKB=T1G3J2 T1G3J2 20215640 PTHR10828:SF76 M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25 M-PHASE INDUCER PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 regulation of cell cycle G2/M phase transition#GO:1902749;mitotic cell cycle phase transition#GO:0044772;regulation of mitotic cell cycle phase transition#GO:1901990;cell cycle process#GO:0022402;regulation of cell cycle phase transition#GO:1901987;positive regulation of cell cycle#GO:0045787;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047;cell cycle phase transition#GO:0044770;positive regulation of cellular process#GO:0048522;regulation of cell cycle process#GO:0010564;regulation of biological process#GO:0050789;G2/M transition of mitotic cell cycle#GO:0000086;mitotic cell cycle#GO:0000278;regulation of meiotic cell cycle#GO:0051445;regulation of cellular process#GO:0050794;positive regulation of cell cycle process#GO:0090068;positive regulation of mitotic cell cycle#GO:0045931;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of G2/M transition of mitotic cell cycle#GO:0010389;positive regulation of biological process#GO:0048518;regulation of mitotic cell cycle#GO:0007346;cell cycle G2/M phase transition#GO:0044839 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG179218|UniProtKB=T1FED5 T1FED5 20207184 PTHR47202:SF2 HISTIDINE-RICH GLYCOPROTEIN G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG153326|UniProtKB=T1EL39 T1EL39 20197289 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG79313|UniProtKB=T1G3M5 T1G3M5 20215673 PTHR21257:SF38 DELTA(14)-STEROL REDUCTASE 7-DEHYDROCHOLESTEROL REDUCTASE oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor#GO:0016628 sterol metabolic process#GO:0016125;organic hydroxy compound metabolic process#GO:1901615;lipid metabolic process#GO:0006629;organic hydroxy compound biosynthetic process#GO:1901617;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;regulation of hormone levels#GO:0010817;lipid biosynthetic process#GO:0008610;primary metabolic process#GO:0044238;hormone metabolic process#GO:0042445;steroid metabolic process#GO:0008202;organic cyclic compound metabolic process#GO:1901360;phytosteroid metabolic process#GO:0016128;regulation of biological quality#GO:0065008;biological regulation#GO:0065007;steroid biosynthetic process#GO:0006694;metabolic process#GO:0008152;sterol biosynthetic process#GO:0016126;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG79707|UniProtKB=T1G3S4 T1G3S4 20215722 PTHR10030:SF37 ALPHA-L-FUCOSIDASE ALPHA-L-FUCOSIDASE-RELATED hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 monosaccharide metabolic process#GO:0005996;carbohydrate derivative metabolic process#GO:1901135;glycosyl compound catabolic process#GO:1901658;carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;hexose metabolic process#GO:0019318;glycosyl compound metabolic process#GO:1901657;carbohydrate metabolic process#GO:0005975;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;lysosome#GO:0005764;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;vacuole#GO:0005773;cellular anatomical entity#GO:0110165;lytic vacuole#GO:0000323;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosidase#PC00110;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG78992|UniProtKB=T1G3H9 T1G3H9 20215627 PTHR24418:SF373 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE SRC42A protein tyrosine kinase activity#GO:0004713;non-membrane spanning protein tyrosine kinase activity#GO:0004715;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein binding#GO:0005515;catalytic activity, acting on a protein#GO:0140096;signaling receptor binding#GO:0005102;kinase activity#GO:0016301;protein kinase activity#GO:0004672 response to external biotic stimulus#GO:0043207;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;immune response#GO:0006955;developmental process#GO:0032502;cell communication#GO:0007154;cellular process#GO:0009987;defense response to symbiont#GO:0140546;regulation of biological process#GO:0050789;immune system process#GO:0002376;response to stimulus#GO:0050896;response to external stimulus#GO:0009605;cell differentiation#GO:0030154;enzyme-linked receptor protein signaling pathway#GO:0007167;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to other organism#GO:0098542;regulation of cellular process#GO:0050794;response to other organism#GO:0051707;cell surface receptor signaling pathway#GO:0007166;biological process involved in interspecies interaction between organisms#GO:0044419;biological regulation#GO:0065007;innate immune response#GO:0045087;defense response#GO:0006952;signaling#GO:0023052;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169 non-receptor tyrosine protein kinase#PC00168 Parkinson disease#P00049>Src kinase#P01230;Integrin signalling pathway#P00034>Src#P00940 HELRO|EnsemblGenome=HelroG189623|UniProtKB=T1FR77 T1FR77 20211324 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG86834|UniProtKB=T1G6H8 T1G6H8 20216675 PTHR10159:SF528 DUAL SPECIFICITY PROTEIN PHOSPHATASE PUCKERED, ISOFORM A hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 regulation of MAPK cascade#GO:0043408;negative regulation of biological process#GO:0048519;peptidyl-tyrosine dephosphorylation#GO:0035335;macromolecule modification#GO:0043412;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;protein modification process#GO:0036211;regulation of intracellular signal transduction#GO:1902531;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;negative regulation of MAPK cascade#GO:0043409;nitrogen compound metabolic process#GO:0006807;regulation of signal transduction#GO:0009966;protein metabolic process#GO:0019538;negative regulation of cellular process#GO:0048523;negative regulation of cell communication#GO:0010648;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;regulation of cell communication#GO:0010646;negative regulation of response to stimulus#GO:0048585;macromolecule metabolic process#GO:0043170;negative regulation of signaling#GO:0023057;cellular metabolic process#GO:0044237;protein dephosphorylation#GO:0006470;organonitrogen compound metabolic process#GO:1901564;cellular process#GO:0009987;primary metabolic process#GO:0044238;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;dephosphorylation#GO:0016311;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG191692|UniProtKB=T1FT77 T1FT77 20212024 PTHR39369:SF6 LIN-24 (TWENTY-FOUR) LIKE LIN-24 (TWENTY-FOUR) LIKE HELRO|EnsemblGenome=HelroG167969|UniProtKB=T1F007 T1F007 20202157 PTHR45617:SF172 LEUCINE RICH REPEAT FAMILY PROTEIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN 15-LIKE scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG78629|UniProtKB=T1G3D8 T1G3D8 20215586 PTHR43595:SF2 37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL SMALL RIBOSOMAL SUBUNIT PROTEIN MS42 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG97472|UniProtKB=T1G9G8 T1G9G8 20217715 PTHR12431:SF14 SORTING NEXIN 17 AND 27 LD15323P lipid binding#GO:0008289;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;binding#GO:0005488 endosomal transport#GO:0016197;localization within membrane#GO:0051668;cellular localization#GO:0051641;vesicle-mediated transport to the plasma membrane#GO:0098876;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;endocytic recycling#GO:0032456;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;early endosome#GO:0005769;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG86265|UniProtKB=T1G695 T1G695 20216592 PTHR11461:SF372 SERINE PROTEASE INHIBITOR, SERPIN ACCESSORY GLAND PROTEIN ACP76A-RELATED extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG192690|UniProtKB=T1FU72 T1FU72 20212368 PTHR13232:SF10 NAD(P)H-HYDRATE EPIMERASE NAD(P)H-HYDRATE EPIMERASE epimerase/racemase#PC00096;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG185384|UniProtKB=T1FMR0 T1FMR0 20210109 PTHR31885:SF6 GH04784P GH04784P hydrolase activity#GO:0016787;catalytic activity#GO:0003824 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG67965|UniProtKB=T1FZ87 T1FZ87 20214135 PTHR46212:SF3 PEFLIN GH27120P HELRO|EnsemblGenome=HelroG108365|UniProtKB=T1EEI5 T1EEI5 20194987 PTHR11920:SF494 GUANYLYL CYCLASE ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2 adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 Gonadotropin-releasing hormone receptor pathway#P06664>Npr2#P06796;Endothelin signaling pathway#P00019>Guanylate cyclase#P00581 HELRO|EnsemblGenome=HelroG116952|UniProtKB=T1EGI7 T1EGI7 20195689 PTHR11524:SF16 60S RIBOSOMAL PROTEIN L7 LARGE RIBOSOMAL SUBUNIT PROTEIN UL30 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of LSU-rRNA#GO:0000470;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG69237|UniProtKB=T1FZR4 T1FZR4 20214312 PTHR12210:SF13 DULLARD PROTEIN PHOSPHATASE CTD SMALL PHOSPHATASE-LIKE PROTEIN 3 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG99073|UniProtKB=T1G9Q8 T1G9Q8 20217804 PTHR10799:SF923 SNF2/RAD54 HELICASE FAMILY LYMPHOID-SPECIFIC HELICASE ATP-dependent activity, acting on DNA#GO:0008094;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on DNA#GO:0140097 DNA helicase#PC00011;DNA metabolism protein#PC00009 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG121951|UniProtKB=T1EGT3 T1EGT3 20195783 PTHR19444:SF13 UNC-93 RELATED PROTEIN UNC-93 HOMOLOG A membrane-bound signaling molecule#PC00152 HELRO|EnsemblGenome=HelroG62958|UniProtKB=T1FX85 T1FX85 20213433 PTHR37001:SF9 PHOSPHORYN, PUTATIVE-RELATED-RELATED METHYL-ACCEPTING TRANSDUCER DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG68685|UniProtKB=T1FZI3 T1FZI3 20214231 PTHR13355:SF11 GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;catalytic activity#GO:0003824;N-acyltransferase activity#GO:0016410 acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG100598|UniProtKB=T1ED07 T1ED07 20194459 PTHR21290:SF25 SPHINGOMYELIN SYNTHETASE SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;membrane lipid biosynthetic process#GO:0046467;sphingolipid metabolic process#GO:0006665;primary metabolic process#GO:0044238;ceramide metabolic process#GO:0006672;amide biosynthetic process#GO:0043604;membrane lipid metabolic process#GO:0006643;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;ceramide biosynthetic process#GO:0046513;cellular lipid metabolic process#GO:0044255;amide metabolic process#GO:0043603;sphingolipid biosynthetic process#GO:0030148;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;Golgi membrane#GO:0000139;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG69014|UniProtKB=T1FZN5 T1FZN5 20214283 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG166576|UniProtKB=T1EY96 T1EY96 20201546 PTHR16489:SF12 GH11727P GH11727P phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;positive regulation of molecular function#GO:0044093;regulation of dephosphorylation#GO:0035303;regulation of catalytic activity#GO:0050790;positive regulation of protein modification process#GO:0031401;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;regulation of hydrolase activity#GO:0051336;positive regulation of biological process#GO:0048518;regulation of phosphoprotein phosphatase activity#GO:0043666;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;positive regulation of catalytic activity#GO:0043085;regulation of phosphatase activity#GO:0010921;positive regulation of phosphorus metabolic process#GO:0010562;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of hydrolase activity#GO:0051345;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;positive regulation of protein metabolic process#GO:0051247;positive regulation of phosphate metabolic process#GO:0045937;response to stress#GO:0006950;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cellular response to stress#GO:0033554;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG184454|UniProtKB=T1FL85 T1FL85 20209584 PTHR12400:SF21 INOSITOL POLYPHOSPHATE KINASE KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301 organic hydroxy compound metabolic process#GO:1901615;organophosphate biosynthetic process#GO:0090407;alcohol biosynthetic process#GO:0046165;cellular metabolic process#GO:0044237;alcohol metabolic process#GO:0006066;organic hydroxy compound biosynthetic process#GO:1901617;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;organophosphate metabolic process#GO:0019637;small molecule biosynthetic process#GO:0044283;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 kinase#PC00137 HELRO|EnsemblGenome=HelroG63219|UniProtKB=T1FXC5 T1FXC5 20213473 PTHR10032:SF271 ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS RH12261P-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG84604|UniProtKB=T1G5K7 T1G5K7 20216354 PTHR24543:SF334 MULTICOPPER OXIDASE-RELATED F5_8 TYPE C DOMAIN-CONTAINING PROTEIN oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG117121|UniProtKB=T1EGK4 T1EGK4 20195705 PTHR10217:SF548 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL GH12235P monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG166590|UniProtKB=T1EYA1 T1EYA1 20201551 PTHR11949:SF17 INTERFERON REGULATORY FACTOR IRF TRYPTOPHAN PENTAD REPEAT DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG176694|UniProtKB=T1FAS6 T1FAS6 20205925 PTHR47032:SF1 UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG194254|UniProtKB=T1FVV4 T1FVV4 20212950 PTHR16484:SF17 PARTITIONING DEFECTIVE 3 RELATED BAZOOKA, ISOFORM B lipid binding#GO:0008289;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;binding#GO:0005488 establishment or maintenance of cell polarity#GO:0007163;cellular localization#GO:0051641;organelle localization#GO:0051640;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;macromolecule localization#GO:0033036;microtubule cytoskeleton organization#GO:0000226;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cellular process#GO:0009987;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of cell polarity#GO:0030010;cellular macromolecule localization#GO:0070727;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;organelle organization#GO:0006996;centrosome localization#GO:0051642;establishment of localization in cell#GO:0051649;establishment or maintenance of apical/basal cell polarity#GO:0035088;cytoskeleton organization#GO:0007010;establishment or maintenance of bipolar cell polarity#GO:0061245;establishment of organelle localization#GO:0051656 cytoplasm#GO:0005737;anchoring junction#GO:0070161;cell-cell junction#GO:0005911;cell junction#GO:0030054;plasma membrane region#GO:0098590;adherens junction#GO:0005912;cell cortex#GO:0005938;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886;apical junction complex#GO:0043296;apical part of cell#GO:0045177;intracellular anatomical structure#GO:0005622;apical plasma membrane#GO:0016324 HELRO|EnsemblGenome=HelroG177566|UniProtKB=T1FBV9 T1FBV9 20206308 PTHR24213:SF9 ACTIN-BINDING LIM PROTEIN UNCOORDINATED 115A, ISOFORM B-RELATED cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cell projection organization#GO:0030030;cellular component organization#GO:0016043;plasma membrane bounded cell projection assembly#GO:0120031;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Axon guidance mediated by netrin#P00009>Ablim#P00358 HELRO|EnsemblGenome=HelroG190875|UniProtKB=T1FSD7 T1FSD7 20211734 PTHR44675:SF1 PAK1 INTERACTING PROTEIN 1 P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1 HELRO|EnsemblGenome=HelroG173132|UniProtKB=T1F6F2 T1F6F2 20204401 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77676|UniProtKB=T1G321 T1G321 20215469 PTHR12998:SF0 TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG tRNA methyltransferase activity#GO:0008175;catalytic activity, acting on RNA#GO:0140098;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;RNA methyltransferase activity#GO:0008173 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;macromolecule methylation#GO:0043414;tRNA methylation#GO:0030488;organic cyclic compound metabolic process#GO:1901360;methylation#GO:0032259;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;RNA methylation#GO:0001510;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 HELRO|EnsemblGenome=HelroG185424|UniProtKB=T1FMT1 T1FMT1 20210130 PTHR18860:SF159 14-3-3 PROTEIN 14-3-3 PROTEIN ZETA localization#GO:0051179;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular localization#GO:0051641;cellular response to stimulus#GO:0051716;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052;protein localization#GO:0008104 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 Parkinson disease#P00049>14-3-3#P01238;FGF signaling pathway#P00021>14-3-3#P00624;EGF receptor signaling pathway#P00018>14-3-3#P00539;PI3 kinase pathway#P00048>14-3-3#P01206 HELRO|EnsemblGenome=HelroG72973|UniProtKB=T1G181 T1G181 20214829 PTHR24409:SF413 ZINC FINGER PROTEIN 142 DATILOGRAFO, ISOFORM A-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG170619|UniProtKB=T1F391 T1F391 20203290 PTHR12356:SF19 NUCLEAR MOVEMENT PROTEIN NUDC NUDC DOMAIN-CONTAINING PROTEIN 3 protein binding#GO:0005515;unfolded protein binding#GO:0051082;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG102143|UniProtKB=T1ED83 T1ED83 20194535 PTHR19375:SF169 HEAT SHOCK PROTEIN 70KDA HEAT SHOCK 70 KDA PROTEIN 13 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 Hsp70 family chaperone#PC00027 HELRO|EnsemblGenome=HelroG62285|UniProtKB=T1FWY7 T1FWY7 20213335 PTHR48051:SF61 FAMILY NOT NAMED LEUCINE-RICH REPEAT PROTEIN LRRA-LIKE cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG195025|UniProtKB=T1FWN8 T1FWN8 20213233 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG193262|UniProtKB=T1FUT2 T1FUT2 20212578 PTHR10091:SF0 ALDOSE-1-EPIMERASE GALACTOSE MUTAROTASE racemase and epimerase activity, acting on carbohydrates and derivatives#GO:0016857;isomerase activity#GO:0016853;catalytic activity#GO:0003824 monosaccharide metabolic process#GO:0005996;small molecule catabolic process#GO:0044282;carbohydrate catabolic process#GO:0016052;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;hexose metabolic process#GO:0019318;carbohydrate metabolic process#GO:0005975;glucose metabolic process#GO:0006006;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704 epimerase/racemase#PC00096;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG100479|UniProtKB=T1ECZ9 T1ECZ9 20194451 PTHR11102:SF147 SEL-1-LIKE PROTEIN SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE response to organic substance#GO:0010033;macromolecule catabolic process#GO:0009057;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;response to organonitrogen compound#GO:0010243;ERAD pathway#GO:0036503;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG78719|UniProtKB=T1G3E9 T1G3E9 20215597 PTHR23023:SF266 DIMETHYLANILINE MONOOXYGENASE FLAVIN-CONTAINING MONOOXYGENASE oxygenase#PC00177;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG65623|UniProtKB=T1FYA8 T1FYA8 20213806 PTHR12107:SF0 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT STARGAZIN (MAMMALIAN CALCIUM CHANNEL) HOMOLOG calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;voltage-gated channel activity#GO:0022832;molecular function regulator activity#GO:0098772;transporter regulator activity#GO:0141108;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;channel regulator activity#GO:0016247;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;inorganic cation transmembrane transporter activity#GO:0022890 cellular localization#GO:0051641;macromolecule localization#GO:0033036;receptor internalization#GO:0031623;system process#GO:0003008;transport#GO:0006810;regulation of signaling#GO:0023051;nitrogen compound transport#GO:0071705;regulation of localization#GO:0032879;endosome to lysosome transport#GO:0008333;lysosomal transport#GO:0007041;establishment of protein localization#GO:0045184;regulation of biological process#GO:0050789;organic substance transport#GO:0071702;regulation of transport#GO:0051049;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;regulation of molecular function#GO:0065009;regulation of signal transduction#GO:0009966;receptor-mediated endocytosis#GO:0006898;regulation of monoatomic ion transmembrane transporter activity#GO:0032412;regulation of transmembrane transporter activity#GO:0022898;protein localization to organelle#GO:0033365;regulation of transporter activity#GO:0032409;positive regulation of signaling#GO:0023056;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;positive regulation of biological process#GO:0048518;localization within membrane#GO:0051668;regulation of cell communication#GO:0010646;establishment of protein localization to vacuole#GO:0072666;regulation of transmembrane transport#GO:0034762;vacuolar transport#GO:0007034;endocytosis#GO:0006897;protein localization to vacuole#GO:0072665;vesicle-mediated transport#GO:0016192;establishment of protein localization to organelle#GO:0072594;nervous system process#GO:0050877;cell communication#GO:0007154;cellular process#GO:0009987;regulation of synaptic transmission, glutamatergic#GO:0051966;protein localization#GO:0008104;positive regulation of cellular process#GO:0048522;localization#GO:0051179;regulation of response to stimulus#GO:0048583;protein localization to lysosome#GO:0061462;cellular macromolecule localization#GO:0070727;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;positive regulation of cell communication#GO:0010647;protein transport#GO:0015031;biological regulation#GO:0065007;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;regulation of trans-synaptic signaling#GO:0099177;multicellular organismal process#GO:0032501;intracellular transport#GO:0046907;positive regulation of synaptic transmission#GO:0050806;import into cell#GO:0098657;protein-containing complex localization#GO:0031503 membrane protein complex#GO:0098796;synapse#GO:0045202;postsynaptic specialization#GO:0099572;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;plasma membrane signaling receptor complex#GO:0098802;transporter complex#GO:1990351;plasma membrane protein complex#GO:0098797;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;neuron to neuron synapse#GO:0098984;membrane#GO:0016020;synaptic membrane#GO:0097060;asymmetric synapse#GO:0032279;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;transmembrane transporter complex#GO:1902495;postsynaptic density membrane#GO:0098839;postsynaptic specialization membrane#GO:0099634;plasma membrane region#GO:0098590;postsynapse#GO:0098794;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG193777|UniProtKB=T1FVC4 T1FVC4 20212770 PTHR10529:SF270 AP COMPLEX SUBUNIT MU AP-4 COMPLEX SUBUNIT MU-1 cellular localization#GO:0051641;macromolecule localization#GO:0033036;vacuolar transport#GO:0007034;post-Golgi vesicle-mediated transport#GO:0006892;transport#GO:0006810;protein targeting#GO:0006605;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;lysosomal transport#GO:0007041;cytosolic transport#GO:0016482;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;Golgi to vacuole transport#GO:0006896;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi apparatus subcompartment#GO:0098791;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG74919|UniProtKB=T1G1X8 T1G1X8 20215076 PTHR12220:SF13 50S/60S RIBOSOMAL PROTEIN L16 LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;rRNA binding#GO:0019843;binding#GO:0005488;organic cyclic compound binding#GO:0097159 ribosomal protein#PC00202;translational protein#PC00263 Opioid prodynorphin pathway#P05916>SNARE Complex#P05996;Opioid proenkephalin pathway#P05915>SNARE Complex#P05986;5HT3 type receptor mediated signaling pathway#P04375>SNARE Complex#P04423;Opioid proopiomelanocortin pathway#P05917>SNARE Complex#P06005;Thyrotropin-releasing hormone receptor signaling pathway#P04394>SNARE Complex#P04582;Beta1 adrenergic receptor signaling pathway#P04377>SNARE Complex#P04435;Cortocotropin releasing factor receptor signaling pathway#P04380>SNARE Complex#P04457;Dopamine receptor mediated signaling pathway#P05912>SNARE Complex#P05956;Oxytocin receptor mediated signaling pathway#P04391>SNARE Complex#P04532;5HT2 type receptor mediated signaling pathway#P04374>SNARE Complex#P04415;Beta3 adrenergic receptor signaling pathway#P04379>SNARE Complex#P04447;5HT1 type receptor mediated signaling pathway#P04373>SNARE Complex#P04405;5HT4 type receptor mediated signaling pathway#P04376>SNARE Complex#P04428;Beta2 adrenergic receptor signaling pathway#P04378>SNARE Complex#P04442 HELRO|EnsemblGenome=HelroG165792|UniProtKB=T1EXA4 T1EXA4 20201204 PTHR11614:SF87 PHOSPHOLIPASE-RELATED MONOGLYCERIDE LIPASE hydrolase activity#GO:0016787;lipase activity#GO:0016298;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 cellular anatomical entity#GO:0110165;membrane#GO:0016020 phospholipase#PC00186;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG160117|UniProtKB=T1EPT9 T1EPT9 20198589 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182683|UniProtKB=T1FIK8 T1FIK8 20208657 PTHR47027:SF29 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG155730|UniProtKB=T1ELL6 T1ELL6 20197466 PTHR13359:SF2 39S RIBOSOMAL PROTEIN L40, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN ML40 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;organellar ribosome#GO:0000313;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG171077|UniProtKB=T1F3S7 T1F3S7 20203476 PTHR11360:SF251 MONOCARBOXYLATE TRANSPORTER MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN transporter#PC00227 HELRO|EnsemblGenome=HelroG106950|UniProtKB=T1EE61 T1EE61 20194863 PTHR13817:SF175 TITIN IG-LIKE AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN C27B7.7 structural protein#PC00211 HELRO|EnsemblGenome=HelroG168359|UniProtKB=T1F0G8 T1F0G8 20202318 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG184803|UniProtKB=T1FM09 T1FM09 20209858 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG184813|UniProtKB=T1FM15 T1FM15 20209864 PTHR12098:SF2 E3 UBIQUITIN-PROTEIN LIGASE PELLINO-RELATED PROTEIN PELLINO transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG194945|UniProtKB=T1FWL5 T1FWL5 20213210 PTHR46527:SF1 NUCLEOPORIN-LIKE PROTEIN 2 NUCLEOPORIN NUP42 transporter#PC00227 HELRO|EnsemblGenome=HelroG184031|UniProtKB=T1FKG6 T1FKG6 20209315 PTHR42884:SF14 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED NEUROENDOCRINE CONVERTASE 1 hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;membrane#GO:0016020 serine protease#PC00203;protein modifying enzyme#PC00260 Endothelin signaling pathway#P00019>furin#P00575;Alzheimer disease-presenilin pathway#P00004>Furin#P00157;Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105 HELRO|EnsemblGenome=HelroG64434|UniProtKB=T1FXU7 T1FXU7 20213645 PTHR24343:SF299 SERINE/THREONINE KINASE SERINE_THREONINE-PROTEIN KINASE KIN-29 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG63136|UniProtKB=T1FXB5 T1FXB5 20213463 PTHR45833:SF1 METHIONINE SYNTHASE METHIONINE SYNTHASE methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;sulfur compound metabolic process#GO:0006790;proteinogenic amino acid biosynthetic process#GO:0170038;folic acid-containing compound metabolic process#GO:0006760;biosynthetic process#GO:0009058;carboxylic acid biosynthetic process#GO:0046394;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular modified amino acid metabolic process#GO:0006575;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;L-amino acid metabolic process#GO:0170033;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;heterocycle metabolic process#GO:0046483;proteinogenic amino acid metabolic process#GO:0170039;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;aspartate family amino acid biosynthetic process#GO:0009067;alpha-amino acid biosynthetic process#GO:1901607;aspartate family amino acid metabolic process#GO:0009066;L-amino acid biosynthetic process#GO:0170034;small molecule biosynthetic process#GO:0044283;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 S-adenosylmethionine biosynthesis#P02773>Cobalamin-dependent homocysteine transmethylase#P03142;Methionine biosynthesis#P02753>Homocysteine transmethylase#P03024;Formyltetrahydrofolate biosynthesis#P02743>Cobalamin dependent homocysteine transmethylase#P02953 HELRO|EnsemblGenome=HelroG158705|UniProtKB=T1EN53 T1EN53 20198003 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185321|UniProtKB=T1FMN7 T1FMN7 20210086 PTHR43884:SF9 ACYL-COA DEHYDROGENASE COMPLEX I ASSEMBLY FACTOR ACAD9, MITOCHONDRIAL oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG165207|UniProtKB=T1EWF7 T1EWF7 20200907 PTHR23196:SF1 PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN PAX-INTERACTING PROTEIN 1 HELRO|EnsemblGenome=HelroG67798|UniProtKB=T1FZ55 T1FZ55 20214103 PTHR43816:SF1 NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;pentosyltransferase activity#GO:0016763;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;pyridine nucleotide metabolic process#GO:0019362;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;nucleotide biosynthetic process#GO:0009165;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;nicotinamide nucleotide metabolic process#GO:0046496;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG179731|UniProtKB=T1FF31 T1FF31 20207430 PTHR11683:SF12 MYELIN PROTEOLIPID M6, ISOFORM F cellular developmental process#GO:0048869;neurogenesis#GO:0022008;cell projection organization#GO:0030030;multicellular organism development#GO:0007275;developmental process#GO:0032502;cellular component organization#GO:0016043;cellular process#GO:0009987;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;system development#GO:0048731;neuron projection development#GO:0031175;cell differentiation#GO:0030154;anatomical structure development#GO:0048856;neuron differentiation#GO:0030182;neuron development#GO:0048666;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 myelin protein#PC00161 HELRO|EnsemblGenome=HelroG64757|UniProtKB=T1FXY6 T1FXY6 20213684 PTHR23101:SF25 RAB GDP/GTP EXCHANGE FACTOR GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1 nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;binding#GO:0005488;molecular function regulator activity#GO:0098772;enzyme binding#GO:0019899;protein binding#GO:0005515;small GTPase binding#GO:0031267;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;endocytic vesicle#GO:0030139;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG177678|UniProtKB=T1FC24 T1FC24 20206373 PTHR11533:SF299 PROTEASE M1 ZINC METALLOPROTEASE AMINOPEPTIDASE metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;amide binding#GO:0033218;metal ion binding#GO:0046872;peptidase activity#GO:0008233;metalloaminopeptidase activity#GO:0070006;cation binding#GO:0043169;peptide binding#GO:0042277;hydrolase activity#GO:0016787;aminopeptidase activity#GO:0004177;exopeptidase activity#GO:0008238;ion binding#GO:0043167;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;peptide catabolic process#GO:0043171;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;membrane#GO:0016020;extracellular region#GO:0005576;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191446|UniProtKB=T1FSZ9 T1FSZ9 20211946 PTHR10288:SF338 KH DOMAIN CONTAINING RNA BINDING PROTEIN IGF-II MRNA-BINDING PROTEIN, ISOFORM L nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159;mRNA 3'-UTR binding#GO:0003730 developmental process#GO:0032502;multicellular organism development#GO:0007275;nervous system development#GO:0007399;regulation of biological process#GO:0050789;system development#GO:0048731;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG164841|UniProtKB=T1EVV5 T1EVV5 20200705 PTHR14948:SF25 NG5 DUF4190 DOMAIN-CONTAINING PROTEIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG92925|UniProtKB=T1G8N9 T1G8N9 20217436 PTHR11537:SF252 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;delayed rectifier potassium channel activity#GO:0005251;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG187888|UniProtKB=T1FPG2 T1FPG2 20210709 PTHR47096:SF1 MISSHAPEN LIKE KINASE 1 MISSHAPEN LIKE KINASE 1 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG70414|UniProtKB=T1G063 T1G063 20214461 PTHR15362:SF15 PHOSPHATIDYLINOSITOL SYNTHASE PHOSPHATIDYLSERINE SYNTHASE 1 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG174317|UniProtKB=T1F7Z6 T1F7Z6 20204945 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG143175|UniProtKB=T1EJ92 T1EJ92 20196642 PTHR21032:SF0 G PATCH DOMAIN-CONTAINING PROTEIN 11 G PATCH DOMAIN-CONTAINING PROTEIN 11 supramolecular complex#GO:0099080;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;kinetochore#GO:0000776;chromosome#GO:0005694;condensed chromosome, centromeric region#GO:0000779;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;chromosomal region#GO:0098687;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG179596|UniProtKB=T1FEX3 T1FEX3 20207372 PTHR11753:SF4 ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY AP COMPLEX SUBUNIT SIGMA localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;cellular process#GO:0009987;transport#GO:0006810 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG175839|UniProtKB=T1F9R1 T1F9R1 20205560 PTHR46510:SF1 BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA metabolic process#GO:0051052;positive regulation of cellular metabolic process#GO:0031325;regulation of cellular component organization#GO:0051128;regulation of RNA biosynthetic process#GO:2001141;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;biological regulation#GO:0065007;regulation of chromatin organization#GO:1902275;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG103807|UniProtKB=T1EDH6 T1EDH6 20194628 PTHR10137:SF0 V-TYPE PROTON ATPASE SUBUNIT C V-TYPE PROTON ATPASE SUBUNIT C inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;proton transmembrane transporter activity#GO:0015078;active monoatomic ion transmembrane transporter activity#GO:0022853;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;inorganic cation transmembrane transporter activity#GO:0022890;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;vacuolar membrane#GO:0005774;ATPase complex#GO:1904949;vacuole#GO:0005773;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;proton-transporting two-sector ATPase complex#GO:0016469;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG107666|UniProtKB=T1EEC1 T1EEC1 20194923 PTHR11920:SF501 GUANYLYL CYCLASE GUANYLATE CYCLASE 32E adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG102544|UniProtKB=T1EDA3 T1EDA3 20194555 PTHR19134:SF542 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE S hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 cellular component organization or biogenesis#GO:0071840;synapse organization#GO:0050808;cell junction organization#GO:0034330;cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;synaptic membrane adhesion#GO:0099560;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cellular process#GO:0009987 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG152267|UniProtKB=T1EKQ3 T1EKQ3 20197153 PTHR31195:SF2 GEO02494P1 GEO02494P1 HELRO|EnsemblGenome=HelroG192399|UniProtKB=T1FTW8 T1FTW8 20212265 PTHR46766:SF1 GLUTAMINE-RICH PROTEIN 2 GLUTAMINE-RICH PROTEIN 2 HELRO|EnsemblGenome=HelroG91778|UniProtKB=T1G887 T1G887 20217284 PTHR23506:SF26 GH10249P MFS-TYPE TRANSPORTER SLC18B1 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG168474|UniProtKB=T1F0M2 T1F0M2 20202372 PTHR24418:SF384 TYROSINE-PROTEIN KINASE ACTIVATED CDC42 KINASE 1 protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG65571|UniProtKB=T1FYA0 T1FYA0 20213798 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG185223|UniProtKB=T1FMJ0 T1FMJ0 20210039 PTHR15315:SF26 RING FINGER PROTEIN 41, 151 E3 UBIQUITIN-PROTEIN LIGASE NRDP1 HELRO|EnsemblGenome=HelroG188393|UniProtKB=T1FPY0 T1FPY0 20210877 PTHR11927:SF9 GALACTOSIDE 2-L-FUCOSYLTRANSFERASE L-FUCOSYLTRANSFERASE transferase activity#GO:0016740;fucosyltransferase activity#GO:0008417;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein glycosylation#GO:0006486;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycosylation#GO:0070085;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG183013|UniProtKB=T1FJ31 T1FJ31 20208830 PTHR15592:SF27 MATRIN 3/NUCLEAR PROTEIN 220-RELATED HEPHAESTUS, ISOFORM Y nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nitrogen compound metabolic process#GO:0051171;regulation of biosynthetic process#GO:0009889;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG80892|UniProtKB=T1G468 T1G468 20215866 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;heme binding#GO:0020037 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG84286|UniProtKB=T1G5H0 T1G5H0 20216317 PTHR13452:SF10 THUMP DOMAIN CONTAINING PROTEIN 1-RELATED THUMP DOMAIN-CONTAINING PROTEIN 1 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;tRNA metabolic process#GO:0006399;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG189235|UniProtKB=T1FQU5 T1FQU5 20211192 PTHR23320:SF130 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED TRANSMEMBRANE PROTEIN 212 transporter#PC00227 HELRO|EnsemblGenome=HelroG70180|UniProtKB=T1G032 T1G032 20214430 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-LIKE 1 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;localization#GO:0051179;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 membrane protein complex#GO:0098796;synapse#GO:0045202;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron projection#GO:0043005;transmembrane transporter complex#GO:1902495;cell projection#GO:0042995;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HELRO|EnsemblGenome=HelroG172067|UniProtKB=T1F4Z9 T1F4Z9 20203898 PTHR24056:SF254 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 2 transferase activity#GO:0016740;cyclin-dependent protein kinase activity#GO:0097472;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein serine/threonine kinase activity#GO:0004674;protein binding#GO:0005515;cyclin binding#GO:0030332;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 signal transduction#GO:0007165;mitotic cell cycle phase transition#GO:0044772;macromolecule modification#GO:0043412;cell cycle G1/S phase transition#GO:0044843;cell cycle process#GO:0022402;protein modification process#GO:0036211;mitotic cell cycle process#GO:1903047;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;G1/S transition of mitotic cell cycle#GO:0000082;regulation of biological process#GO:0050789;mitotic cell cycle#GO:0000278;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;phosphorylation#GO:0016310;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;regulation of cell cycle G2/M phase transition#GO:1902749;regulation of mitotic cell cycle phase transition#GO:1901990;macromolecule metabolic process#GO:0043170;regulation of cell cycle phase transition#GO:1901987;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;cell cycle phase transition#GO:0044770;primary metabolic process#GO:0044238;regulation of cell cycle process#GO:0010564;response to stimulus#GO:0050896;regulation of cellular biosynthetic process#GO:0031326;response to chemical#GO:0042221;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of G2/M transition of mitotic cell cycle#GO:0010389;regulation of mitotic cell cycle#GO:0007346;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695 non-receptor serine/threonine protein kinase#PC00167 EGF receptor signaling pathway#P00018>ERK1-2#P00543;p53 pathway#P00059>Cdc2#P04634;p53 pathway feedback loops 2#P04398>cdk2#P04653;p53 pathway#P00059>Cdk2#P04625 HELRO|EnsemblGenome=HelroG82314|UniProtKB=T1G4Q6 T1G4Q6 20216054 PTHR10891:SF989 EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN EF-HAND DOMAIN-CONTAINING PROTEIN calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG178119|UniProtKB=T1FCR9 T1FCR9 20206618 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG165060|UniProtKB=T1EW82 T1EW82 20200832 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED BRCT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG126000|UniProtKB=T1EH80 T1EH80 20195930 PTHR45669:SF22 GLUTAREDOXIN DOMAIN-CONTAINING CYSTEINE-RICH PROTEIN CG12206-RELATED GLUTAREDOXIN DOMAIN-CONTAINING CYSTEINE-RICH PROTEIN CG12206-RELATED oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG73151|UniProtKB=T1G1A9 T1G1A9 20214857 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161856|UniProtKB=T1ERZ0 T1ERZ0 20199340 PTHR45873:SF1 DNA POLYMERASE ETA DNA POLYMERASE ETA DNA-directed DNA polymerase activity#GO:0003887;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on DNA#GO:0140097;DNA polymerase activity#GO:0034061 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;response to radiation#GO:0009314;cellular nitrogen compound biosynthetic process#GO:0044271;response to abiotic stimulus#GO:0009628;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;postreplication repair#GO:0006301;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;translesion synthesis#GO:0019985;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;nucleobase-containing compound biosynthetic process#GO:0034654;DNA biosynthetic process#GO:0071897;DNA synthesis involved in DNA repair#GO:0000731;aromatic compound biosynthetic process#GO:0019438;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;site of DNA damage#GO:0090734;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;site of double-strand break#GO:0035861;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;replication fork#GO:0005657 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG184213|UniProtKB=T1FKS1 T1FKS1 20209420 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168686|UniProtKB=T1F0V0 T1F0V0 20202450 PTHR31077:SF1 U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;precatalytic spliceosome#GO:0071011;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185388|UniProtKB=T1FMR3 T1FMR3 20210112 PTHR13165:SF0 ARSENITE-RESISTANCE PROTEIN 2 SERRATE RNA EFFECTOR MOLECULE HOMOLOG negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;RNA metabolic process#GO:0016070;regulatory ncRNA processing#GO:0070918;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;regulatory ncRNA-mediated gene silencing#GO:0031047;miRNA processing#GO:0035196;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary miRNA processing#GO:0031053;primary metabolic process#GO:0044238;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear body#GO:0016604;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG101596|UniProtKB=T1ED56 T1ED56 20194508 PTHR24072:SF156 RHO FAMILY GTPASE RHO-RELATED BTB DOMAIN CONTAINING, ISOFORM B GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;enzyme binding#GO:0019899;ribonucleoside triphosphate phosphatase activity#GO:0017111;kinase binding#GO:0019900;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817;protein kinase binding#GO:0019901;anion binding#GO:0043168;ion binding#GO:0043167 establishment or maintenance of cell polarity#GO:0007163;regulation of anatomical structure morphogenesis#GO:0022603;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cytoskeleton organization#GO:0051493;regulation of cell shape#GO:0008360;regulation of biological quality#GO:0065008;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;organelle organization#GO:0006996;cortical cytoskeleton organization#GO:0030865;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;regulation of actin filament-based process#GO:0032970 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG185918|UniProtKB=T1FNF8 T1FNF8 20210355 PTHR10802:SF2 MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40 MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40 HOMOLOG 1-RELATED protein transmembrane transporter activity#GO:0008320;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular localization#GO:0051641;transmembrane transport#GO:0055085;macromolecule localization#GO:0033036;transport#GO:0006810;protein transmembrane transport#GO:0071806;protein targeting#GO:0006605;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;protein localization to mitochondrion#GO:0070585;cellular process#GO:0009987;protein transmembrane import into intracellular organelle#GO:0044743;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;mitochondrial transport#GO:0006839;organic substance transport#GO:0071702;protein import into mitochondrial matrix#GO:0030150;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein targeting to mitochondrion#GO:0006626;establishment of protein localization to mitochondrion#GO:0072655;protein transport#GO:0015031;protein localization to organelle#GO:0033365;mitochondrial transmembrane transport#GO:1990542 envelope#GO:0031975;bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane#GO:0005741;mitochondrial outer membrane translocase complex#GO:0005742;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867;mitochondrial protein-containing complex#GO:0098798 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG177173|UniProtKB=T1FBB4 T1FBB4 20206113 PTHR47246:SF1 MUCIN-19 MUCIN-19 HELRO|EnsemblGenome=HelroG71395|UniProtKB=T1G0K7 T1G0K7 20214605 PTHR10264:SF127 BAND 7 PROTEIN-RELATED PODOCIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG186293|UniProtKB=T1FNX8 T1FNX8 20210525 PTHR12935:SF0 GAMMA-GLUTAMYLCYCLOTRANSFERASE GAMMA-GLUTAMYLCYCLOTRANSFERASE lyase activity#GO:0016829;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG155808|UniProtKB=T1ELM5 T1ELM5 20197475 PTHR12729:SF6 TRNA(HIS) GUANYLYLTRANSFERASE-RELATED TRNA(HIS) GUANYLYLTRANSFERASE-RELATED catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;tRNA metabolic process#GO:0006399;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG161981|UniProtKB=T1ES43 T1ES43 20199393 PTHR12062:SF0 N-ACETYLGLUCOSAMINYLTRANSFERASE VI ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE B acetylglucosaminyltransferase activity#GO:0008375;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG179328|UniProtKB=T1FEK1 T1FEK1 20207250 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG182535|UniProtKB=T1FIB8 T1FIB8 20208567 PTHR19282:SF511 TETRASPANIN TETRASPANIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG177430|UniProtKB=T1FBP3 T1FBP3 20206242 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159629|UniProtKB=T1EP95 T1EP95 20198395 PTHR23107:SF34 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN HTH LA-TYPE RNA-BINDING DOMAIN-CONTAINING PROTEIN transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG74077|UniProtKB=T1G1M1 T1G1M1 20214969 PTHR46066:SF2 CHITINASE DOMAIN-CONTAINING PROTEIN 1 FAMILY MEMBER CHITINASE DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG66682|UniProtKB=T1FYP0 T1FYP0 20213938 PTHR23001:SF3 EUKARYOTIC TRANSLATION INITIATION FACTOR EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2 translation regulator activity#GO:0045182;nucleic acid binding#GO:0003676;translation regulator activity, nucleic acid binding#GO:0090079;translation initiation factor activity#GO:0003743;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation factor activity, RNA binding#GO:0008135 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG192393|UniProtKB=T1FTW4 T1FTW4 20212261 PTHR10288:SF340 KH DOMAIN CONTAINING RNA BINDING PROTEIN HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG69505|UniProtKB=T1FZW1 T1FZW1 20214359 PTHR13152:SF0 TFIIH, POLYPEPTIDE 4 GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4 nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;nucleotide-excision repair#GO:0006289;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;serine/threonine protein kinase complex#GO:1902554;RNA polymerase II transcription regulator complex#GO:0090575;protein kinase complex#GO:1902911;transcription factor TFIIH core complex#GO:0000439;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase II, holoenzyme#GO:0016591;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;transcription factor TFIIH holo complex#GO:0005675;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;general transcription factor#PC00259 Transcription regulation by bZIP transcription factor#P00055>TFIIH complex#P01392;General transcription regulation#P00023>TFIIH complex#P00664 HELRO|EnsemblGenome=HelroG66900|UniProtKB=T1FYS7 T1FYS7 20213975 PTHR12566:SF9 CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB CYTOPLASMIC POLYADENYLATION ELEMENT-BINDING PROTEIN 1 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;translation regulator activity#GO:0045182;binding#GO:0005488;organic cyclic compound binding#GO:0097159;ribonucleoprotein complex binding#GO:0043021;ribosome binding#GO:0043022;mRNA binding#GO:0003729;protein-containing complex binding#GO:0044877;translation regulator activity, nucleic acid binding#GO:0090079;translation factor activity, RNA binding#GO:0008135;mRNA 3'-UTR binding#GO:0003730 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of protein metabolic process#GO:0051246;negative regulation of biosynthetic process#GO:0009890;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of translation#GO:0017148;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;synapse#GO:0045202;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;neuron projection#GO:0043005;cell junction#GO:0030054;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG68968|UniProtKB=T1FZM7 T1FZM7 20214275 PTHR10026:SF144 CYCLIN CYCLIN-K protein kinase activator activity#GO:0030295;protein kinase regulator activity#GO:0019887;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;kinase regulator activity#GO:0019207;kinase activator activity#GO:0019209 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of DNA-templated transcription, elongation#GO:0032786;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;regulation of DNA-templated transcription elongation#GO:0032784;regulation of DNA-templated transcription#GO:0006355;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;transcription elongation factor complex#GO:0008023;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 kinase activator#PC00138 Cell cycle#P00013>CdkC#P00489 HELRO|EnsemblGenome=HelroG190036|UniProtKB=T1FRM1 T1FRM1 20211468 PTHR23327:SF42 RING FINGER PROTEIN 127 LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG194380|UniProtKB=T1FW00 T1FW00 20212996 PTHR13466:SF0 TEX2 PROTEIN-RELATED SMP-LTD DOMAIN-CONTAINING PROTEIN lipid binding#GO:0008289;binding#GO:0005488 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG177018|UniProtKB=T1FB54 T1FB54 20206053 PTHR31144:SF1 UPF0602 PROTEIN C4ORF47 UPF0602 PROTEIN C4ORF47 supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cytoplasmic microtubule#GO:0005881;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG85297|UniProtKB=T1G5V1 T1G5V1 20216448 PTHR24409:SF418 ZINC FINGER PROTEIN 142 SI:CH73-221F6.1 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG186255|UniProtKB=T1FNV6 T1FNV6 20210503 PTHR10606:SF44 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;transferase activity, transferring phosphorus-containing groups#GO:0016772;sugar-phosphatase activity#GO:0050308;carbohydrate kinase activity#GO:0019200;kinase activity#GO:0016301;phosphoric ester hydrolase activity#GO:0042578 carbohydrate derivative metabolic process#GO:1901135;cellular metabolic process#GO:0044237;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 carbohydrate phosphatase#PC00066;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG190685|UniProtKB=T1FS73 T1FS73 20211670 PTHR13802:SF52 MUCIN 4-RELATED MUCIN-4 HELRO|EnsemblGenome=HelroG100932|UniProtKB=T1ED20 T1ED20 20194472 PTHR23252:SF24 INTIMAL THICKNESS RECEPTOR-RELATED TRANSMEMBRANE PROTEIN 145 HELRO|EnsemblGenome=HelroG176603|UniProtKB=T1FAP9 T1FAP9 20205898 PTHR11202:SF22 SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER PROTEIN ENABLED scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG110490|UniProtKB=T1EF28 T1EF28 20195180 PTHR23406:SF90 MALIC ENZYME-RELATED MALIC ENZYME-RELATED oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 oxoacid metabolic process#GO:0043436;dicarboxylic acid metabolic process#GO:0043648;cellular metabolic process#GO:0044237;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG173809|UniProtKB=T1F792 T1F792 20204691 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175105|UniProtKB=T1F8V0 T1F8V0 20205249 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG96017|UniProtKB=T1G998 T1G998 20217645 PTHR10454:SF232 CASPASE AT03047P-RELATED cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197;hydrolase activity#GO:0016787;cysteine-type endopeptidase activity involved in apoptotic process#GO:0097153;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175 regulation of biological process#GO:0050789;positive regulation of apoptotic process#GO:0043065;positive regulation of programmed cell death#GO:0043068;regulation of apoptotic process#GO:0042981;regulation of cellular process#GO:0050794;apoptotic process#GO:0006915;biological regulation#GO:0065007;cell death#GO:0008219;programmed cell death#GO:0012501;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of programmed cell death#GO:0043067;positive regulation of cellular process#GO:0048522 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 protease#PC00190;protein modifying enzyme#PC00260 FAS signaling pathway#P00020>Caspase6#P00596;FAS signaling pathway#P00020>Pro-Caspase6#P00607 HELRO|EnsemblGenome=HelroG156111|UniProtKB=T1ELR7 T1ELR7 20197517 PTHR45909:SF1 ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1 ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1 GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;anion binding#GO:0043168;ion binding#GO:0043167 protein localization to plasma membrane#GO:0072659;localization within membrane#GO:0051668;cellular localization#GO:0051641;vesicle-mediated transport to the plasma membrane#GO:0098876;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;post-Golgi vesicle-mediated transport#GO:0006892;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;protein localization to Golgi apparatus#GO:0034067;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;establishment of protein localization#GO:0045184;Golgi to plasma membrane transport#GO:0006893;protein localization#GO:0008104;localization#GO:0051179;protein localization to cell periphery#GO:1990778;organic substance transport#GO:0071702;establishment of protein localization to membrane#GO:0090150;Golgi to plasma membrane protein transport#GO:0043001;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG71434|UniProtKB=T1G0L6 T1G0L6 20214614 PTHR11662:SF399 SOLUTE CARRIER FAMILY 17 FI19708P1-RELATED secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG178840|UniProtKB=T1FDT5 T1FDT5 20206984 PTHR24179:SF29 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12 LD46604P phosphatase regulator activity#GO:0019208;enzyme inhibitor activity#GO:0004857;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG177084|UniProtKB=T1FB79 T1FB79 20206078 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG99560|UniProtKB=T1G9T6 T1G9T6 20217832 PTHR23077:SF171 AAA-FAMILY ATPASE NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE pyrophosphatase activity#GO:0016462;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG84020|UniProtKB=T1G5D4 T1G5D4 20216281 PTHR10075:SF14 BASIGIN RELATED CELL ADHESION MOLECULE DSCAM2-RELATED scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG160886|UniProtKB=T1EQU3 T1EQU3 20198943 PTHR15099:SF2 PROTEIN PM1 TRANSMEMBRANE PROTEIN 11, MITOCHONDRIAL cellular component organization or biogenesis#GO:0071840;membrane organization#GO:0061024;organelle organization#GO:0006996;cellular component organization#GO:0016043;mitochondrial membrane organization#GO:0007006;mitochondrion organization#GO:0007005;cellular process#GO:0009987;inner mitochondrial membrane organization#GO:0007007 envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG156562|UniProtKB=T1ELY2 T1ELY2 20197582 PTHR36983:SF2 DNAJ HOMOLOG SUBFAMILY C MEMBER 13 DNAJ HOMOLOG SUBFAMILY C MEMBER 13 localization#GO:0051179;establishment of localization#GO:0051234;transport#GO:0006810;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;receptor-mediated endocytosis#GO:0006898;cellular process#GO:0009987;import into cell#GO:0098657 bounding membrane of organelle#GO:0098588;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;vesicle membrane#GO:0012506;organelle#GO:0043226;membrane#GO:0016020;endosome membrane#GO:0010008;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cytoplasmic vesicle membrane#GO:0030659 chaperone#PC00072 HELRO|EnsemblGenome=HelroG72832|UniProtKB=T1G160 T1G160 20214808 PTHR12777:SF0 SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2 SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;spliceosomal snRNP assembly#GO:0000387;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375 catalytic step 2 spliceosome#GO:0071013;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;U4/U6 x U5 tri-snRNP complex#GO:0046540;U1 snRNP#GO:0005685;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;U5 snRNP#GO:0005682;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;pICln-Sm protein complex#GO:0034715;protein-containing complex#GO:0032991;U2 snRNP#GO:0005686;spliceosomal tri-snRNP complex#GO:0097526;precatalytic spliceosome#GO:0071011;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG190294|UniProtKB=T1FRV5 T1FRV5 20211552 PTHR23121:SF9 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 transmembrane transporter activity#GO:0022857;sugar transmembrane transporter activity#GO:0051119;transporter activity#GO:0005215;carbohydrate transmembrane transporter activity#GO:0015144 transporter#PC00227 HELRO|EnsemblGenome=HelroG186121|UniProtKB=T1FNP4 T1FNP4 20210441 PTHR14324:SF3 CONDENSIN-2 COMPLEX SUBUNIT H2 CONDENSIN-2 COMPLEX SUBUNIT H2 protein-containing complex binding#GO:0044877;binding#GO:0005488;chromatin binding#GO:0003682 nuclear chromosome segregation#GO:0098813;chromosome separation#GO:0051304;mitotic sister chromatid separation#GO:0051306;sister chromatid segregation#GO:0000819;meiotic cell cycle#GO:0051321;nuclear division#GO:0000280;cell cycle process#GO:0022402;chromosome condensation#GO:0030261;cellular component organization#GO:0016043;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;chromosome organization involved in meiotic cell cycle#GO:0070192;mitotic cell cycle#GO:0000278;reproduction#GO:0000003;organelle organization#GO:0006996;chromosome organization#GO:0051276;meiotic cell cycle process#GO:1903046;sexual reproduction#GO:0019953;reproductive process#GO:0022414;cell cycle#GO:0007049;mitotic nuclear division#GO:0140014;organelle fission#GO:0048285;mitotic sister chromatid segregation#GO:0000070 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG181243|UniProtKB=T1FGS3 T1FGS3 20208022 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG145735|UniProtKB=T1EJM5 T1EJM5 20196775 PTHR11849:SF304 ETS DNA-BINDING PROTEIN D-ETS-3 transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG176350|UniProtKB=T1FAF1 T1FAF1 20205800 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG77557|UniProtKB=T1G2Z8 T1G2Z8 20215446 PTHR11920:SF501 GUANYLYL CYCLASE GUANYLATE CYCLASE 32E adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG178273|UniProtKB=T1FD07 T1FD07 20206706 PTHR36694:SF11 PASIFLORA 1, ISOFORM A-RELATED LP21121P-RELATED HELRO|EnsemblGenome=HelroG90252|UniProtKB=T1G7N3 T1G7N3 20217080 PTHR45721:SF12 LAMIN DM0-RELATED INTERMEDIATE FILAMENT PROTEIN IFA-1 structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;nuclear migration#GO:0007097;cellular localization#GO:0051641;negative regulation of biological process#GO:0048519;protein-DNA complex organization#GO:0071824;organelle localization#GO:0051640;macromolecule localization#GO:0033036;membrane organization#GO:0061024;transport#GO:0006810;protein localization to nucleus#GO:0034504;nucleus organization#GO:0006997;endomembrane system organization#GO:0010256;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;protein localization to organelle#GO:0033365;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;establishment of organelle localization#GO:0051656;negative regulation of cellular process#GO:0048523;localization within membrane#GO:0051668;negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;cellular process#GO:0009987;negative regulation of gene expression, epigenetic#GO:0045814;epigenetic regulation of gene expression#GO:0040029;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular macromolecule localization#GO:0070727;heterochromatin organization#GO:0070828;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;chromatin organization#GO:0006325;intracellular transport#GO:0046907;nuclear envelope organization#GO:0006998;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323;protein-containing complex localization#GO:0031503 membrane-enclosed lumen#GO:0031974;envelope#GO:0031975;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;nuclear periphery#GO:0034399;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981 HELRO|EnsemblGenome=HelroG113622|UniProtKB=T1EFU3 T1EFU3 20195445 PTHR46116:SF39 (E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 6 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG82441|UniProtKB=T1G4S2 T1G4S2 20216070 PTHR46010:SF1 PROTEIN IWS1 HOMOLOG PROTEIN IWS1 HOMOLOG poly(A)+ mRNA export from nucleus#GO:0016973;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;mRNA transport#GO:0051028;RNA localization#GO:0006403;localization#GO:0051179;organic substance transport#GO:0071702;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG167096|UniProtKB=T1EZ08 T1EZ08 20201808 PTHR22426:SF2 ARGININE_SERINE-RICH COILED-COIL PROTEIN 2 ARGININE_SERINE-RICH COILED-COIL PROTEIN 2 HELRO|EnsemblGenome=HelroG189570|UniProtKB=T1FR59 T1FR59 20211306 PTHR12948:SF3 NEDD8 ULTIMATE BUSTER-1 BS4 PROTEIN NEDD8 ULTIMATE BUSTER 1 regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of proteolysis#GO:0030162;regulation of catabolic process#GO:0009894;regulation of protein metabolic process#GO:0051246;regulation of macromolecule metabolic process#GO:0060255;regulation of nitrogen compound metabolic process#GO:0051171;biological regulation#GO:0065007;regulation of proteolysis involved in protein catabolic process#GO:1903050;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;regulation of metabolic process#GO:0019222 HELRO|EnsemblGenome=HelroG113130|UniProtKB=T1EFQ4 T1EFQ4 20195406 PTHR11895:SF7 TRANSAMIDASE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL metabolite interconversion enzyme#PC00262;ligase#PC00142 HELRO|EnsemblGenome=HelroG184133|UniProtKB=T1FKN0 T1FKN0 20209379 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG74042|UniProtKB=T1G1L4 T1G1L4 20214962 PTHR12308:SF84 ANOCTAMIN ANOCTAMIN inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216 localization#GO:0051179;inorganic anion transmembrane transport#GO:0098661;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;transport#GO:0006810;chloride transport#GO:0006821;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG188320|UniProtKB=T1FPV4 T1FPV4 20210851 PTHR12854:SF7 ATAXIN 2-RELATED ATAXIN-2 HOMOLOG nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;non-membrane-bounded organelle assembly#GO:0140694;cellular process#GO:0009987 supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;cytoplasmic stress granule#GO:0010494;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic ribonucleoprotein granule#GO:0036464 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG111519|UniProtKB=T1EFC0 T1EFC0 20195272 PTHR12001:SF55 GERANYLGERANYL PYROPHOSPHATE SYNTHASE ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS2 prenyltransferase activity#GO:0004659;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;isoprenoid metabolic process#GO:0006720;primary metabolic process#GO:0044238;isoprenoid biosynthetic process#GO:0008299;ubiquinone biosynthetic process#GO:0006744;small molecule biosynthetic process#GO:0044283;cellular lipid metabolic process#GO:0044255;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG98101|UniProtKB=T1G9K6 T1G9K6 20217752 PTHR14167:SF81 SH3 DOMAIN-CONTAINING ENDOPHILIN-A scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG106217|UniProtKB=T1EE09 T1EE09 20194811 PTHR12811:SF0 VACUOLAR PROTEIN SORTING VPS16 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;actin binding#GO:0003779;binding#GO:0005488 localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;endosomal transport#GO:0016197;cellular localization#GO:0051641;vacuole organization#GO:0007033;establishment of localization#GO:0051234;organelle organization#GO:0006996;vacuole fusion, non-autophagic#GO:0042144;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;cellular component organization#GO:0016043;cellular process#GO:0009987;organelle fusion#GO:0048284 bounding membrane of organelle#GO:0098588;lytic vacuole membrane#GO:0098852;membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle tethering complex#GO:0099023;vacuolar membrane#GO:0005774;vacuole#GO:0005773;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;lytic vacuole#GO:0000323;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;lysosomal membrane#GO:0005765;protein-containing complex#GO:0032991;lysosome#GO:0005764;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG142649|UniProtKB=T1EJ66 T1EJ66 20196616 PTHR24418:SF373 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE SRC42A protein tyrosine kinase activity#GO:0004713;non-membrane spanning protein tyrosine kinase activity#GO:0004715;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein binding#GO:0005515;catalytic activity, acting on a protein#GO:0140096;signaling receptor binding#GO:0005102;kinase activity#GO:0016301;protein kinase activity#GO:0004672 response to external biotic stimulus#GO:0043207;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;immune response#GO:0006955;developmental process#GO:0032502;cell communication#GO:0007154;cellular process#GO:0009987;defense response to symbiont#GO:0140546;regulation of biological process#GO:0050789;immune system process#GO:0002376;response to stimulus#GO:0050896;response to external stimulus#GO:0009605;cell differentiation#GO:0030154;enzyme-linked receptor protein signaling pathway#GO:0007167;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to other organism#GO:0098542;regulation of cellular process#GO:0050794;response to other organism#GO:0051707;cell surface receptor signaling pathway#GO:0007166;biological process involved in interspecies interaction between organisms#GO:0044419;biological regulation#GO:0065007;innate immune response#GO:0045087;defense response#GO:0006952;signaling#GO:0023052;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169 non-receptor tyrosine protein kinase#PC00168 Parkinson disease#P00049>Src kinase#P01230;Integrin signalling pathway#P00034>Src#P00940 HELRO|EnsemblGenome=HelroG66289|UniProtKB=T1FYJ3 T1FYJ3 20213891 PTHR23300:SF0 METHANETHIOL OXIDASE METHANETHIOL OXIDASE defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG184306|UniProtKB=T1FKY3 T1FKY3 20209482 PTHR35711:SF1 EXPRESSED PROTEIN ECTODERMAL, ISOFORM F HELRO|EnsemblGenome=HelroG172649|UniProtKB=T1F5Q2 T1F5Q2 20204151 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG187587|UniProtKB=T1FPA9 T1FPA9 20210656 PTHR11811:SF25 6-PHOSPHOGLUCONATE DEHYDROGENASE 6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;pyridine nucleotide metabolic process#GO:0019362;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;carbohydrate catabolic process#GO:0016052;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;carbohydrate metabolic process#GO:0005975;NADP metabolic process#GO:0006739;purine nucleotide metabolic process#GO:0006163;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;heterocycle metabolic process#GO:0046483;generation of precursor metabolites and energy#GO:0006091;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;nicotinamide nucleotide metabolic process#GO:0046496;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;glucose 6-phosphate metabolic process#GO:0051156;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;carboxylic acid metabolic process#GO:0019752;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092;oxidoreductase#PC00176 Pentose phosphate pathway#P02762>Gluconate Dehydrogenase#P03070 HELRO|EnsemblGenome=HelroG186168|UniProtKB=T1FNR5 T1FNR5 20210462 PTHR46989:SF3 USP DOMAIN-CONTAINING PROTEIN USPA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG156082|UniProtKB=T1ELR6 T1ELR6 20197516 PTHR23065:SF11 PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1 SYNDAPIN, ISOFORM C lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488 regulation of endocytosis#GO:0030100;membrane organization#GO:0061024;plasma membrane organization#GO:0007009;endomembrane system organization#GO:0010256;regulation of localization#GO:0032879;regulation of cellular component organization#GO:0051128;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of transport#GO:0051049;regulation of cellular process#GO:0050794;organelle organization#GO:0006996;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG177496|UniProtKB=T1FBS8 T1FBS8 20206277 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG88726|UniProtKB=T1G759 T1G759 20216906 PTHR24353:SF153 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;cytosol#GO:0005829;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Enkephalin release#P05913>PKA#P05972;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Endothelin signaling pathway#P00019>PKA#P00570;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059 HELRO|EnsemblGenome=HelroG75089|UniProtKB=T1G202 T1G202 20215100 PTHR11827:SF73 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS KAZACHOC, ISOFORM G inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium ion transmembrane transporter activity#GO:0015079;symporter activity#GO:0015293;chloride transmembrane transporter activity#GO:0015108;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 inorganic ion homeostasis#GO:0098771;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;inorganic anion transmembrane transport#GO:0098661;import across plasma membrane#GO:0098739;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;inorganic anion transport#GO:0015698;potassium ion transport#GO:0006813;regulation of anatomical structure size#GO:0090066;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;monoatomic anion transmembrane transport#GO:0098656;chloride transport#GO:0006821;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;cellular component organization#GO:0016043;cellular process#GO:0009987;chemical homeostasis#GO:0048878;regulation of cellular component size#GO:0032535;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;regulation of cell size#GO:0008361;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;potassium ion import across plasma membrane#GO:1990573 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG88502|UniProtKB=T1G734 T1G734 20216881 PTHR10926:SF0 CELL CYCLE CONTROL PROTEIN 50 CDC50, ISOFORM A cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG173689|UniProtKB=T1F743 T1F743 20204642 PTHR11673:SF6 TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER EUKARYOTIC TRANSLATION INITIATION FACTOR 5A-RELATED nucleic acid binding#GO:0003676;translation regulator activity#GO:0045182;translation regulator activity, nucleic acid binding#GO:0090079;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation elongation factor activity#GO:0003746;translation factor activity, RNA binding#GO:0008135 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;translational elongation#GO:0006414;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG184854|UniProtKB=T1FM32 T1FM32 20209881 PTHR19862:SF14 WD REPEAT-CONTAINING PROTEIN 48 WD REPEAT-CONTAINING PROTEIN 48 protein binding#GO:0005515;ubiquitin-like protein binding#GO:0032182;binding#GO:0005488;ubiquitin binding#GO:0043130 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;double-strand break repair via homologous recombination#GO:0000724;nucleobase-containing compound metabolic process#GO:0006139;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG189751|UniProtKB=T1FRC1 T1FRC1 20211368 PTHR23150:SF33 SULFATASE MODIFYING FACTOR 1, 2 INACTIVE C-ALPHA-FORMYLGLYCINE-GENERATING ENZYME 2 oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG188645|UniProtKB=T1FQ77 T1FQ77 20210974 PTHR13103:SF2 SCHWANNOMIN INTERACTING PROTEIN 1 IQCJ-SCHIP1 READTHROUGH TRANSCRIPT PROTEIN-RELATED regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;positive regulation of response to stimulus#GO:0048584;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;positive regulation of signal transduction#GO:0009967;positive regulation of cell communication#GO:0010647;regulation of signaling#GO:0023051;biological regulation#GO:0065007;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of signaling#GO:0023056;regulation of intracellular signal transduction#GO:1902531;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 cell junction#GO:0030054;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG192280|UniProtKB=T1FTS6 T1FTS6 20212223 PTHR14030:SF4 MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1 BUB1 KINASE, ISOFORM A-RELATED transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;catalytic activity#GO:0003824;protein kinase activity#GO:0004672 meiotic sister chromatid cohesion#GO:0051177;negative regulation of sister chromatid segregation#GO:0033046;negative regulation of mitotic sister chromatid separation#GO:2000816;negative regulation of biological process#GO:0048519;regulation of mitotic nuclear division#GO:0007088;signal transduction#GO:0007165;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;regulation of chromosome segregation#GO:0051983;mitotic cell cycle checkpoint signaling#GO:0007093;negative regulation of chromosome organization#GO:2001251;regulation of chromosome separation#GO:1905818;negative regulation of mitotic nuclear division#GO:0045839;cell cycle process#GO:0022402;regulation of cellular component organization#GO:0051128;negative regulation of cell cycle process#GO:0010948;negative regulation of nuclear division#GO:0051784;negative regulation of mitotic sister chromatid segregation#GO:0033048;mitotic cell cycle process#GO:1903047;regulation of biological process#GO:0050789;cell cycle checkpoint signaling#GO:0000075;sister chromatid cohesion#GO:0007062;negative regulation of mitotic cell cycle phase transition#GO:1901991;mitotic cell cycle#GO:0000278;negative regulation of organelle organization#GO:0010639;regulation of mitotic sister chromatid segregation#GO:0033047;intracellular signal transduction#GO:0035556;negative regulation of cellular component organization#GO:0051129;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;regulation of chromosome organization#GO:0033044;cellular response to stimulus#GO:0051716;regulation of mitotic sister chromatid separation#GO:0010965;regulation of nuclear division#GO:0051783;negative regulation of cell cycle#GO:0045786;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;regulation of organelle organization#GO:0033043;mitotic spindle assembly checkpoint signaling#GO:0007094;negative regulation of chromosome segregation#GO:0051985;regulation of cell cycle phase transition#GO:1901987;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of mitotic cell cycle#GO:0045930;cell communication#GO:0007154;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of mitotic metaphase/anaphase transition#GO:0030071;regulation of cell cycle process#GO:0010564;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;negative regulation of chromosome separation#GO:1905819;organelle organization#GO:0006996;chromosome organization#GO:0051276;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of sister chromatid segregation#GO:0033045;regulation of mitotic cell cycle#GO:0007346;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG160138|UniProtKB=T1EPV2 T1EPV2 20198602 PTHR36191:SF1 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183798|UniProtKB=T1FK75 T1FK75 20209224 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG87696|UniProtKB=T1G6U5 T1G6U5 20216792 PTHR21148:SF25 THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9 PHOSDUCIN-LIKE PROTEIN 1 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG180187|UniProtKB=T1FFK0 T1FFK0 20207599 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG103603|UniProtKB=T1EDG6 T1EDG6 20194618 PTHR10644:SF2 DNA REPAIR/RNA PROCESSING CPSF FAMILY CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 1 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG185685|UniProtKB=T1FN53 T1FN53 20210251 PTHR13382:SF10 MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B ATP SYNTHASE SUBUNIT S, MITOCHONDRIAL cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG90564|UniProtKB=T1G7T1 T1G7T1 20217128 PTHR19290:SF102 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED TRANSCRIPTION FACTOR ATOH8 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 positive regulation of nitrogen compound metabolic process#GO:0051173;neurogenesis#GO:0022008;positive regulation of RNA biosynthetic process#GO:1902680;cell projection organization#GO:0030030;regulation of nitrogen compound metabolic process#GO:0051171;animal organ development#GO:0048513;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;regulation of biological process#GO:0050789;system development#GO:0048731;cell differentiation#GO:0030154;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;anatomical structure morphogenesis#GO:0009653;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;neuron differentiation#GO:0030182;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;multicellular organism development#GO:0007275;cellular component organization#GO:0016043;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;anatomical structure development#GO:0048856;biological regulation#GO:0065007;neuron development#GO:0048666;multicellular organismal process#GO:0032501;positive regulation of RNA metabolic process#GO:0051254;generation of neurons#GO:0048699;sensory organ development#GO:0007423;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG163538|UniProtKB=T1EU61 T1EU61 20200111 PTHR46077:SF5 E3 UBIQUITIN-PROTEIN LIGASE TOPORS RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein monoubiquitination#GO:0006513;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG76393|UniProtKB=T1G2J5 T1G2J5 20215293 PTHR23084:SF263 PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED MORN REPEAT-CONTAINING PROTEIN 1 transferase#PC00220;kinase#PC00137;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG174321|UniProtKB=T1F800 T1F800 20204949 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG75172|UniProtKB=T1G221 T1G221 20215119 PTHR45872:SF2 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;binding#GO:0005488;molecular function regulator activity#GO:0098772;protein binding#GO:0005515;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG175621|UniProtKB=T1F9F8 T1F9F8 20205457 PTHR10827:SF52 RETICULOCALBIN IP16409P cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG163650|UniProtKB=T1EUB5 T1EUB5 20200165 PTHR23103:SF15 ALZHEIMER'S DISEASE BETA-AMYLOID RELATED AMYLOID-BETA-LIKE PROTEIN protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG113050|UniProtKB=T1EFP9 T1EFP9 20195401 PTHR22847:SF745 WD40 REPEAT PROTEIN F-BOX_WD REPEAT-CONTAINING PROTEIN 7 Notch signaling pathway#P00045>Sel 10#P01102 HELRO|EnsemblGenome=HelroG167671|UniProtKB=T1EZN3 T1EZN3 20202033 PTHR45632:SF17 LD33804P KELCH-LIKE PROTEIN 31 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG162820|UniProtKB=T1ET78 T1ET78 20199778 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG190383|UniProtKB=T1FRY2 T1FRY2 20211579 PTHR46335:SF1 CUBILIN CUBILIN HELRO|EnsemblGenome=HelroG190076|UniProtKB=T1FRN7 T1FRN7 20211484 PTHR15126:SF4 SH3-BINDING SH3 DOMAIN-BINDING PROTEIN 2 HELRO|EnsemblGenome=HelroG168952|UniProtKB=T1F167 T1F167 20202567 PTHR46601:SF1 ULP_PROTEASE DOMAIN-CONTAINING PROTEIN ADF-H DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG111692|UniProtKB=T1EFD7 T1EFD7 20195289 PTHR22961:SF16 SER/THR PROTEIN KINASE-TRB SERINE_THREONINE-PROTEIN KINASE 40 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG189730|UniProtKB=T1FRB0 T1FRB0 20211357 PTHR23320:SF167 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MARVEL DOMAIN-CONTAINING PROTEIN transporter#PC00227 HELRO|EnsemblGenome=HelroG161869|UniProtKB=T1ERZ5 T1ERZ5 20199345 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG107560|UniProtKB=T1EEB2 T1EEB2 20194914 PTHR23255:SF72 TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II RECEPTOR PROTEIN SERINE_THREONINE KINASE macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 serine/threonine protein kinase receptor#PC00205 GBB signaling pathway#P06214>SAX#P06307;TGF-beta signaling pathway#P00052>TGFbetareceptors#P01283;TGF-beta signaling pathway#P00052>TGFbetareceptor I#P01278;DPP-SCW signaling pathway#P06212>SAX#P06274;BMP/activin signaling pathway-drosophila#P06211>TGFbetaR I#P06241;SCW signaling pathway#P06216>SAX#P06329 HELRO|EnsemblGenome=HelroG76235|UniProtKB=T1G2H1 T1G2H1 20215269 PTHR11934:SF0 RIBOSE-5-PHOSPHATE ISOMERASE RIBOSE-5-PHOSPHATE ISOMERASE isomerase activity#GO:0016853;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;monosaccharide metabolic process#GO:0005996;heterocycle metabolic process#GO:0046483;carbohydrate derivative metabolic process#GO:1901135;generation of precursor metabolites and energy#GO:0006091;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;pyridine nucleotide metabolic process#GO:0019362;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;glucose 6-phosphate metabolic process#GO:0051156;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;carbohydrate metabolic process#GO:0005975;NADP metabolic process#GO:0006739;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;nucleobase-containing small molecule metabolic process#GO:0055086;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 isomerase#PC00135;metabolite interconversion enzyme#PC00262 Pentose phosphate pathway#P02762>Ribulose 5-P Isomerase#P03071 HELRO|EnsemblGenome=HelroG89291|UniProtKB=T1G7B6 T1G7B6 20216963 PTHR10037:SF288 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM SODIUM CHANNEL PROTEIN PARA monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;sodium channel activity#GO:0005272;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;inorganic cation transmembrane transporter activity#GO:0022890 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;membrane depolarization#GO:0051899;transport#GO:0006810;regulation of membrane potential#GO:0042391;system process#GO:0003008;action potential#GO:0001508;nervous system process#GO:0050877;cell communication#GO:0007154;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;sodium ion transport#GO:0006814;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;multicellular organismal process#GO:0032501;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 membrane protein complex#GO:0098796;sodium channel complex#GO:0034706;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG84358|UniProtKB=T1G5I0 T1G5I0 20216327 PTHR24115:SF1008 KINESIN-RELATED KINESIN-LIKE PROTEIN SUBITO pyrophosphatase activity#GO:0016462;cytoskeletal protein binding#GO:0008092;microtubule motor activity#GO:0003777;tubulin binding#GO:0015631;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;cytoskeletal motor activity#GO:0003774;microtubule binding#GO:0008017;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017;cellular process#GO:0009987 supramolecular complex#GO:0099080;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;microtubule#GO:0005874 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG73049|UniProtKB=T1G192 T1G192 20214840 PTHR10615:SF217 HISTONE ACETYLTRANSFERASE HISTONE ACETYLTRANSFERASE histone modifying activity#GO:0140993;acyltransferase activity#GO:0016746;peptide N-acetyltransferase activity#GO:0034212;binding#GO:0005488;catalytic activity#GO:0003824;protein-macromolecule adaptor activity#GO:0030674;N-acyltransferase activity#GO:0016410;molecular adaptor activity#GO:0060090;histone acetyltransferase activity#GO:0004402;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;N-acetyltransferase activity#GO:0008080;transferase activity#GO:0016740;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;peptide-lysine-N-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;chromatin binding#GO:0003682;protein-containing complex binding#GO:0044877;catalytic activity, acting on a protein#GO:0140096 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG74695|UniProtKB=T1G1U4 T1G1U4 20215042 PTHR20855:SF3 ADIPOR/PROGESTIN RECEPTOR-RELATED LD03007P G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG191529|UniProtKB=T1FT23 T1FT23 20211970 PTHR24161:SF124 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED TRANSIENT RECEPTOR POTENTIAL CHANNEL PYREXIA protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG188445|UniProtKB=T1FPZ7 T1FPZ7 20210894 PTHR12313:SF0 E3 UBIQUITIN-PROTEIN LIGASE RNF5-RELATED RING-TYPE E3 UBIQUITIN TRANSFERASE ubiquitin-like protein conjugating enzyme binding#GO:0044390;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;enzyme binding#GO:0019899;protein binding#GO:0005515;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 response to organic substance#GO:0010033;macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;response to organonitrogen compound#GO:0010243;ERAD pathway#GO:0036503;cellular process#GO:0009987;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;response to nitrogen compound#GO:1901698;modification-dependent macromolecule catabolic process#GO:0043632;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG177722|UniProtKB=T1FC47 T1FC47 20206396 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG166404|UniProtKB=T1EY34 T1EY34 20201484 PTHR12773:SF0 UPF0315 PROTEIN-RELATED MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;cellular component biogenesis#GO:0044085;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA modification#GO:0009451;rRNA modification#GO:0000154;tRNA processing#GO:0008033;RNA processing#GO:0006396;protein modification process#GO:0036211;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;ncRNA metabolic process#GO:0034660;tRNA methylation#GO:0030488;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;ribosome biogenesis#GO:0042254;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;rRNA methylation#GO:0031167;nucleic acid metabolic process#GO:0090304;macromolecule methylation#GO:0043414;methylation#GO:0032259;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;rRNA base methylation#GO:0070475;RNA methylation#GO:0001510 HELRO|EnsemblGenome=HelroG180237|UniProtKB=T1FFL8 T1FFL8 20207617 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG79614|UniProtKB=T1G3Q9 T1G3Q9 20215707 PTHR13718:SF61 RIBOSOMAL S SUBUNIT SMALL RIBOSOMAL SUBUNIT PROTEIN US5M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;cytosol#GO:0005829;small ribosomal subunit#GO:0015935;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG177770|UniProtKB=T1FC83 T1FC83 20206432 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG180041|UniProtKB=T1FFD8 T1FFD8 20207537 PTHR11412:SF136 MACROGLOBULIN / COMPLEMENT CD109 ANTIGEN protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG192507|UniProtKB=T1FU12 T1FU12 20212308 PTHR19134:SF531 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE LAR hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG86007|UniProtKB=T1G658 T1G658 20216555 PTHR10682:SF10 POLY A POLYMERASE POLYNUCLEOTIDE ADENYLYLTRANSFERASE adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;mRNA polyadenylation#GO:0006378;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;mRNA 3'-end processing#GO:0031124;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mRNA processing#GO:0006397;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG71181|UniProtKB=T1G0H6 T1G0H6 20214574 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG185341|UniProtKB=T1FMP5 T1FMP5 20210094 PTHR43323:SF2 3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE HYDROXYMETHYLGLUTARYL-COA SYNTHASE transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;sulfur compound metabolic process#GO:0006790;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;amide metabolic process#GO:0043603;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;acyl-CoA metabolic process#GO:0006637;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;isoprenoid metabolic process#GO:0006720;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;isoprenoid biosynthetic process#GO:0008299;primary metabolic process#GO:0044238;terpenoid biosynthetic process#GO:0016114;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;cellular lipid metabolic process#GO:0044255;terpenoid metabolic process#GO:0006721;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 Cholesterol biosynthesis#P00014>Hydroxymethyl glutaryl CoA synthase#P00498 HELRO|EnsemblGenome=HelroG164612|UniProtKB=T1EVN0 T1EVN0 20200630 PTHR22793:SF12 MYOCARDIN-RELATED TRANSCRIPTION FACTOR-RELATED MYOCARDIN-RELATED TRANSCRIPTION FACTOR, ISOFORM H transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG62661|UniProtKB=T1FX32 T1FX32 20213380 PTHR10029:SF3 ACYLPHOSPHATASE ACYLPHOSPHATASE-RELATED pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824 hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG82402|UniProtKB=T1G4R8 T1G4R8 20216066 PTHR13258:SF0 SYNDETIN SYNDETIN protein binding#GO:0005515;binding#GO:0005488;SNARE binding#GO:0000149 localization#GO:0051179;endosomal transport#GO:0016197;localization within membrane#GO:0051668;cellular localization#GO:0051641;vesicle-mediated transport to the plasma membrane#GO:0098876;endocytic recycling#GO:0032456;establishment of localization#GO:0051234;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;cellular process#GO:0009987 cytoplasm#GO:0005737;endosome#GO:0005768;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;recycling endosome#GO:0055037;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG160685|UniProtKB=T1EQL4 T1EQL4 20198864 PTHR28642:SF1 MEIOSIS 1 ARREST PROTEIN MEIOSIS 1 ARREST PROTEIN male gamete generation#GO:0048232;nuclear chromosome segregation#GO:0098813;chromosome separation#GO:0051304;gamete generation#GO:0007276;cellular process involved in reproduction in multicellular organism#GO:0022412;multicellular organism reproduction#GO:0032504;meiotic cell cycle#GO:0051321;nuclear division#GO:0000280;developmental process#GO:0032502;cell cycle process#GO:0022402;cellular component organization#GO:0016043;cellular process#GO:0009987;meiotic chromosome segregation#GO:0045132;chromosome segregation#GO:0007059;developmental process involved in reproduction#GO:0003006;cellular component organization or biogenesis#GO:0071840;reproduction#GO:0000003;meiotic nuclear division#GO:0140013;organelle organization#GO:0006996;meiotic cell cycle process#GO:1903046;spermatogenesis#GO:0007283;sexual reproduction#GO:0019953;reproductive process#GO:0022414;cell cycle#GO:0007049;organelle fission#GO:0048285;multicellular organismal process#GO:0032501;male meiotic nuclear division#GO:0007140;multicellular organismal reproductive process#GO:0048609 HELRO|EnsemblGenome=HelroG191561|UniProtKB=T1FT30 T1FT30 20211977 PTHR22929:SF0 RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG182965|UniProtKB=T1FJ01 T1FJ01 20208800 PTHR10656:SF42 CELL FATE DETERMINING PROTEIN MAB21-RELATED CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED transferase#PC00220;nucleotidyltransferase#PC00174;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG190937|UniProtKB=T1FSF8 T1FSF8 20211755 PTHR46143:SF1 CALPAIN-7 CALPAIN-7 cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;metabolic process#GO:0008152;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704 Huntington disease#P00029>Calpain#P00788 HELRO|EnsemblGenome=HelroG176214|UniProtKB=T1FAA9 T1FAA9 20205758 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG68761|UniProtKB=T1FZJ3 T1FZJ3 20214241 PTHR22847:SF637 WD40 REPEAT PROTEIN WD REPEAT DOMAIN 5B HELRO|EnsemblGenome=HelroG77993|UniProtKB=T1G362 T1G362 20215510 PTHR11920:SF499 GUANYLYL CYCLASE GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG164474|UniProtKB=T1EVG9 T1EVG9 20200569 PTHR48209:SF2 AGL056WP FI24008P1 HELRO|EnsemblGenome=HelroG190882|UniProtKB=T1FSE0 T1FSE0 20211737 PTHR11037:SF20 TRANSCRIPTION FACTOR CP2 PROTEIN GRAINYHEAD DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG80178|UniProtKB=T1G3Y6 T1G3Y6 20215784 PTHR11575:SF48 5'-NUCLEOTIDASE-RELATED 5'-NUCLEOTIDASE phosphodiesterase#PC00185;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG157532|UniProtKB=T1EMC7 T1EMC7 20197727 PTHR11931:SF0 PHOSPHOGLYCERATE MUTASE PHOSPHOGLYCERATE MUTASE mutase#PC00160 Glycolysis#P00024>Phosphoglyceromutase#P00680 HELRO|EnsemblGenome=HelroG164283|UniProtKB=T1EV73 T1EV73 20200473 PTHR24410:SF23 HL07962P-RELATED BTB DOMAIN-CONTAINING PROTEIN-RELATED defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG130418|UniProtKB=T1EHT8 T1EHT8 20196138 PTHR11814:SF55 SULFATE TRANSPORTER SODIUM-INDEPENDENT SULFATE ANION TRANSPORTER cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG193056|UniProtKB=T1FUK9 T1FUK9 20212505 PTHR12231:SF253 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG100558|UniProtKB=T1ED04 T1ED04 20194456 PTHR23150:SF19 SULFATASE MODIFYING FACTOR 1, 2 FORMYLGLYCINE-GENERATING ENZYME oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein modification process#GO:0036211;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;primary metabolic process#GO:0044238 HELRO|EnsemblGenome=HelroG168355|UniProtKB=T1F0G4 T1F0G4 20202314 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG189096|UniProtKB=T1FQM8 T1FQM8 20211125 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG164358|UniProtKB=T1EVB4 T1EVB4 20200514 PTHR14440:SF7 DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;RNA metabolic process#GO:0016070;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;transcription by RNA polymerase I#GO:0006360;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;rRNA transcription#GO:0009303;nucleolar large rRNA transcription by RNA polymerase I#GO:0042790;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;transcription elongation by RNA polymerase I#GO:0006362;cellular component assembly#GO:0022607;heterocycle metabolic process#GO:0046483;DNA-templated transcription elongation#GO:0006354;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;rRNA metabolic process#GO:0016072;ncRNA transcription#GO:0098781;aromatic compound biosynthetic process#GO:0019438 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;DNA-directed RNA polymerase complex#GO:0000428;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;RNA polymerase I complex#GO:0005736;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG106795|UniProtKB=T1EE50 T1EE50 20194852 PTHR23152:SF4 2-OXOGLUTARATE DEHYDROGENASE 2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 TCA cycle#P00051>alphaketoglutarate Dehydrogenase#P01269 HELRO|EnsemblGenome=HelroG188186|UniProtKB=T1FPR2 T1FPR2 20210809 PTHR12736:SF21 LANC-LIKE PROTEIN LANC-LIKE PROTEIN 2 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG99033|UniProtKB=T1G9Q6 T1G9Q6 20217802 PTHR43775:SF7 FATTY ACID SYNTHASE FATTY ACID SYNTHASE transferase activity#GO:0016740;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824 organic acid biosynthetic process#GO:0016053;lipid metabolic process#GO:0006629;oxoacid metabolic process#GO:0043436;monocarboxylic acid biosynthetic process#GO:0072330;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;fatty acid metabolic process#GO:0006631;small molecule biosynthetic process#GO:0044283;cellular lipid metabolic process#GO:0044255;carboxylic acid metabolic process#GO:0019752;small molecule metabolic process#GO:0044281;fatty acid biosynthetic process#GO:0006633;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG77792|UniProtKB=T1G341 T1G341 20215489 PTHR46614:SF1 MORN REPEAT-CONTAINING PROTEIN 4 MORN REPEAT-CONTAINING PROTEIN 4 response to stimulus#GO:0050896;response to stress#GO:0006950;response to wounding#GO:0009611 cell projection#GO:0042995;cellular anatomical entity#GO:0110165 HELRO|EnsemblGenome=HelroG63917|UniProtKB=T1FXM5 T1FXM5 20213573 PTHR15680:SF9 RIBOSOMAL PROTEIN L19 LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG179476|UniProtKB=T1FER6 T1FER6 20207315 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG82010|UniProtKB=T1G4L9 T1G4L9 20216017 PTHR12622:SF45 DELTEX-RELATED RING-TYPE E3 UBIQUITIN TRANSFERASE transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cell communication#GO:0007154;cellular process#GO:0009987;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;Notch signaling pathway#GO:0007219 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG187900|UniProtKB=T1FPG5 T1FPG5 20210712 PTHR11006:SF60 PROTEIN ARGININE N-METHYLTRANSFERASE PROTEIN ARGININE N-METHYLTRANSFERASE 9 N-methyltransferase activity#GO:0008170;histone modifying activity#GO:0140993;transferase activity#GO:0016740;catalytic activity#GO:0003824;histone methyltransferase activity#GO:0042054;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a protein#GO:0140096;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein methyltransferase activity#GO:0008276 protein-DNA complex organization#GO:0071824;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;cellular component organization#GO:0016043;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;methylation#GO:0032259;macromolecule methylation#GO:0043414;nitrogen compound metabolic process#GO:0006807;protein-containing complex organization#GO:0043933;chromatin organization#GO:0006325;protein metabolic process#GO:0019538;chromatin remodeling#GO:0006338;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG77652|UniProtKB=T1G316 T1G316 20215464 PTHR12728:SF0 BRIX DOMAIN CONTAINING PROTEIN RIBOSOME PRODUCTION FACTOR 2 HOMOLOG nucleic acid binding#GO:0003676;RNA binding#GO:0003723;rRNA binding#GO:0019843;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;biosynthetic process#GO:0009058;ribosomal large subunit biogenesis#GO:0042273;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;ribosomal large subunit assembly#GO:0000027;ribosome biogenesis#GO:0042254;non-membrane-bounded organelle assembly#GO:0140694;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;protein-RNA complex organization#GO:0071826;maturation of LSU-rRNA#GO:0000470 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG163573|UniProtKB=T1EU82 T1EU82 20200132 PTHR21541:SF3 BTB POZ DOMAIN CONTAINING 12 STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX4 cellular aromatic compound metabolic process#GO:0006725;nuclear division#GO:0000280;cell cycle process#GO:0022402;nucleobase-containing compound metabolic process#GO:0006139;reciprocal homologous recombination#GO:0140527;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;meiotic cell cycle process#GO:1903046;meiosis I cell cycle process#GO:0061982;reciprocal meiotic recombination#GO:0007131;reproductive process#GO:0022414;meiosis I#GO:0007127;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule metabolic process#GO:0043170;meiotic cell cycle#GO:0051321;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;DNA recombination#GO:0006310;resolution of meiotic recombination intermediates#GO:0000712;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;reproduction#GO:0000003;organelle organization#GO:0006996;meiotic nuclear division#GO:0140013;sexual reproduction#GO:0019953;cell cycle#GO:0007049;organelle fission#GO:0048285;homologous recombination#GO:0035825;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG76777|UniProtKB=T1G2P4 T1G2P4 20215342 PTHR11347:SF219 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE, ISOFORM I hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric diester hydrolase activity#GO:0008081;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;cAMP-mediated signaling#GO:0019933;signaling#GO:0023052;cyclic-nucleotide-mediated signaling#GO:0019935 phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG177308|UniProtKB=T1FBH4 T1FBH4 20206173 PTHR46576:SF1 BROMO ADJACENT HOMOLOGY DOMAIN-CONTAINING 1 PROTEIN BROMO ADJACENT HOMOLOGY DOMAIN-CONTAINING 1 PROTEIN HELRO|EnsemblGenome=HelroG190956|UniProtKB=T1FSG5 T1FSG5 20211762 PTHR12271:SF66 POLY A POLYMERASE CID PAP -RELATED TERMINAL URIDYLYLTRANSFERASE TAILOR catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 nucleotidyltransferase#PC00174 HELRO|EnsemblGenome=HelroG106284|UniProtKB=T1EE14 T1EE14 20194816 PTHR47958:SF150 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE DDX17-RELATED catalytic activity, acting on RNA#GO:0140098;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640;mRNA binding#GO:0003729 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG88288|UniProtKB=T1G711 T1G711 20216858 PTHR25480:SF0 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 73 C-MAF-INDUCING PROTEIN HELRO|EnsemblGenome=HelroG189228|UniProtKB=T1FQU0 T1FQU0 20211187 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG125752|UniProtKB=T1EH73 T1EH73 20195923 PTHR11266:SF8 PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17 MPV17-LIKE PROTEIN 2 organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;ribonucleoprotein complex biogenesis#GO:0022613;cellular component organization#GO:0016043;ribosome biogenesis#GO:0042254;cellular process#GO:0009987;non-membrane-bounded organelle assembly#GO:0140694 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG171110|UniProtKB=T1F3T7 T1F3T7 20203486 PTHR13333:SF5 M-AAA PROTEASE-INTERACTING PROTEIN 1, MITOCHONDRIAL M-AAA PROTEASE-INTERACTING PROTEIN 1, MITOCHONDRIAL ribonucleoprotein complex binding#GO:0043021;ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877;binding#GO:0005488 localization within membrane#GO:0051668;cellular localization#GO:0051641;macromolecule localization#GO:0033036;membrane organization#GO:0061024;protein localization to membrane#GO:0072657;establishment of protein localization to organelle#GO:0072594;cellular component organization#GO:0016043;protein localization to mitochondrion#GO:0070585;cellular process#GO:0009987;establishment of protein localization#GO:0045184;inner mitochondrial membrane organization#GO:0007007;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to membrane#GO:0090150;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;establishment of protein localization to mitochondrion#GO:0072655;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;protein localization to organelle#GO:0033365;mitochondrion organization#GO:0007005;mitochondrial membrane organization#GO:0007006;protein insertion into membrane#GO:0051205 envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;organelle inner membrane#GO:0019866;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG167612|UniProtKB=T1EZK1 T1EZK1 20202001 PTHR32026:SF10 METHYLTRANSFERASE-LIKE PROTEIN 24 METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG194693|UniProtKB=T1FWB8 T1FWB8 20213114 PTHR35970:SF1 SODIUM CHANNEL AND CLATHRIN LINKER 1 SODIUM CHANNEL AND CLATHRIN LINKER 1 organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;centriole#GO:0005814;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG103921|UniProtKB=T1EDI5 T1EDI5 20194637 PTHR28599:SF1 SMALL INTEGRAL MEMBRANE PROTEIN 12 SMALL INTEGRAL MEMBRANE PROTEIN 12 HELRO|EnsemblGenome=HelroG178410|UniProtKB=T1FD48 T1FD48 20206747 PTHR46232:SF1 SMARCE1 REGULATOR OF CHROMATIN SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1 nucleosome binding#GO:0031491;nucleic acid binding#GO:0003676;chromatin DNA binding#GO:0031490;nuclear receptor binding#GO:0016922;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;transcription factor binding#GO:0008134;DNA-binding transcription factor binding#GO:0140297 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;ATPase complex#GO:1904949;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;SWI/SNF complex#GO:0016514;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG183157|UniProtKB=T1FJ83 T1FJ83 20208882 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG82302|UniProtKB=T1G4Q4 T1G4Q4 20216052 PTHR19957:SF424 SYNTAXIN SYNTAXIN-1A molecular adaptor activity#GO:0060090;protein binding#GO:0005515;SNAP receptor activity#GO:0005484;binding#GO:0005488;SNARE binding#GO:0000149;protein-macromolecule adaptor activity#GO:0030674 vesicle fusion#GO:0006906;cellular localization#GO:0051641;organelle localization#GO:0051640;macromolecule localization#GO:0033036;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;membrane fusion#GO:0061025;exocytosis#GO:0006887;establishment of localization#GO:0051234;organelle organization#GO:0006996;secretion#GO:0046903;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;vesicle organization#GO:0016050;intracellular transport#GO:0046907;export from cell#GO:0140352;secretion by cell#GO:0032940;organelle fusion#GO:0048284 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;SNARE complex#GO:0031201;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034;membrane traffic protein#PC00150 Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079 HELRO|EnsemblGenome=HelroG171207|UniProtKB=T1F3X9 T1F3X9 20203528 PTHR44755:SF8 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide hormone binding#GO:0017046;hormone binding#GO:0042562;binding#GO:0005488;peptide binding#GO:0042277;amide binding#GO:0033218 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG170736|UniProtKB=T1F3D3 T1F3D3 20203332 PTHR23121:SF10 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 4A transmembrane transporter activity#GO:0022857;sugar transmembrane transporter activity#GO:0051119;transporter activity#GO:0005215;carbohydrate transmembrane transporter activity#GO:0015144 transporter#PC00227 HELRO|EnsemblGenome=HelroG173804|UniProtKB=T1F789 T1F789 20204688 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG86160|UniProtKB=T1G678 T1G678 20216575 PTHR10845:SF259 REGULATOR OF G PROTEIN SIGNALING RGS DOMAIN-CONTAINING PROTEIN-RELATED G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG98795|UniProtKB=T1G9P8 T1G9P8 20217794 PTHR24023:SF1044 COLLAGEN ALPHA FIBRILLAR COLLAGEN NC1 DOMAIN-CONTAINING PROTEIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG173147|UniProtKB=T1F6G3 T1F6G3 20204412 PTHR22748:SF6 AP ENDONUCLEASE DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE hydrolase activity, acting on ester bonds#GO:0016788;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;3'-5'-DNA exonuclease activity#GO:0008296;nuclease activity#GO:0004518;DNA exonuclease activity#GO:0004529;catalytic activity#GO:0003824;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097;phosphoric diester hydrolase activity#GO:0008081;exonuclease activity#GO:0004527;3'-5' exonuclease activity#GO:0008408;phosphoric ester hydrolase activity#GO:0042578 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;base-excision repair#GO:0006284;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 HELRO|EnsemblGenome=HelroG186180|UniProtKB=T1FNS1 T1FNS1 20210468 PTHR47385:SF14 CALPONIN TRANSGELIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG108721|UniProtKB=T1EEL8 T1EEL8 20195020 PTHR12869:SF0 SMALL SEVEN TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN BOS COMPLEX SUBUNIT TMEM147 HELRO|EnsemblGenome=HelroG180266|UniProtKB=T1FFN3 T1FFN3 20207632 PTHR12231:SF253 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG80770|UniProtKB=T1G452 T1G452 20215850 PTHR12231:SF253 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG72040|UniProtKB=T1G0U5 T1G0U5 20214693 PTHR43684:SF11 FAMILY NOT NAMED CHROMO DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166405|UniProtKB=T1EY35 T1EY35 20201485 PTHR12210:SF171 DULLARD PROTEIN PHOSPHATASE PHOSPHATASE HERZOG hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG81553|UniProtKB=T1G4F8 T1G4F8 20215956 PTHR20933:SF4 F-BOX ONLY PROTEIN 33 F-BOX INVOLVED IN POLYQ PATHOGENESIS, ISOFORM A HELRO|EnsemblGenome=HelroG165053|UniProtKB=T1EW76 T1EW76 20200826 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG194612|UniProtKB=T1FW88 T1FW88 20213084 PTHR45736:SF1 ZINC FINGER MYM-TYPE PROTEIN WITHOUT CHILDREN, ISOFORM B zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG162439|UniProtKB=T1ESN3 T1ESN3 20199583 PTHR15592:SF27 MATRIN 3/NUCLEAR PROTEIN 220-RELATED HEPHAESTUS, ISOFORM Y nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nitrogen compound metabolic process#GO:0051171;regulation of biosynthetic process#GO:0009889;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG185372|UniProtKB=T1FMQ6 T1FMQ6 20210105 PTHR43602:SF1 FAMILY NOT NAMED ENOYL-COA HYDRATASE DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;catalytic activity#GO:0003824;hydro-lyase activity#GO:0016836 HELRO|EnsemblGenome=HelroG185234|UniProtKB=T1FMJ5 T1FMJ5 20210044 PTHR11705:SF91 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B FI01817P-RELATED metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metallocarboxypeptidase activity#GO:0004181;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;carboxypeptidase activity#GO:0004180 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG165747|UniProtKB=T1EX87 T1EX87 20201187 PTHR12842:SF6 FI01459P FI01459P HELRO|EnsemblGenome=HelroG190363|UniProtKB=T1FRX5 T1FRX5 20211572 PTHR48051:SF21 FAMILY NOT NAMED CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG181150|UniProtKB=T1FGP1 T1FGP1 20207990 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG65856|UniProtKB=T1FYD8 T1FYD8 20213836 PTHR11545:SF2 RIBOSOMAL PROTEIN L13 LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of protein metabolic process#GO:0051246;negative regulation of biosynthetic process#GO:0009890;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of translation#GO:0017148;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG81270|UniProtKB=T1G4C3 T1G4C3 20215921 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG62501|UniProtKB=T1FX16 T1FX16 20213364 PTHR10217:SF435 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EAG monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG188474|UniProtKB=T1FQ12 T1FQ12 20210909 PTHR10671:SF108 EPITHELIAL MEMBRANE PROTEIN-RELATED CLAUDIN FAMILY PROTEIN-RELATED cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG175098|UniProtKB=T1F8U5 T1F8U5 20205244 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194343|UniProtKB=T1FVY5 T1FVY5 20212981 PTHR22803:SF124 MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG194536|UniProtKB=T1FW61 T1FW61 20213057 PTHR14309:SF12 EXPRESSED PROTEIN PH DOMAIN-CONTAINING PROTEIN biological regulation#GO:0065007;regulation of biological process#GO:0050789;regulation of cell differentiation#GO:0045595;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG141211|UniProtKB=T1EJ30 T1EJ30 20196580 PTHR11537:SF113 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;delayed rectifier potassium channel activity#GO:0005251;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG77462|UniProtKB=T1G2Y1 T1G2Y1 20215429 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG115001|UniProtKB=T1EG58 T1EG58 20195560 PTHR10414:SF71 ETHANOLAMINEPHOSPHOTRANSFERASE FI05338P transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;glycerophospholipid metabolic process#GO:0006650;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG193324|UniProtKB=T1FUW0 T1FUW0 20212606 PTHR11822:SF21 NADP-SPECIFIC ISOCITRATE DEHYDROGENASE ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG65456|UniProtKB=T1FY79 T1FY79 20213777 PTHR12223:SF45 VESICULAR MANNOSE-BINDING LECTIN RE50040P carbohydrate binding#GO:0030246;small molecule binding#GO:0036094;binding#GO:0005488;monosaccharide binding#GO:0048029 localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987 bounding membrane of organelle#GO:0098588;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;Golgi membrane#GO:0000139;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG153976|UniProtKB=T1ELD4 T1ELD4 20197384 PTHR43083:SF6 MANNAN POLYMERASE II MANNAN POLYMERASE COMPLEXES SUBUNIT MNN9 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG81783|UniProtKB=T1G4I7 T1G4I7 20215985 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG97663|UniProtKB=T1G9I4 T1G9I4 20217731 PTHR19965:SF82 RNA AND EXPORT FACTOR BINDING PROTEIN THO COMPLEX SUBUNIT 4 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;mRNA transport#GO:0051028;RNA localization#GO:0006403;localization#GO:0051179;organic substance transport#GO:0071702;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG194441|UniProtKB=T1FW21 T1FW21 20213017 PTHR11588:SF462 TUBULIN TUBULIN ALPHA CHAIN carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;structural molecule activity#GO:0005198;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;structural constituent of cytoskeleton#GO:0005200 cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;microtubule-based process#GO:0007017;organelle organization#GO:0006996;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;cell cycle#GO:0007049;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 tubulin#PC00228;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG106891|UniProtKB=T1EE57 T1EE57 20194859 PTHR31322:SF2 E3 UBIQUITIN-PROTEIN LIGASE TM129 E3 UBIQUITIN-PROTEIN LIGASE TM129 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG161485|UniProtKB=T1ERJ1 T1ERJ1 20199191 PTHR23004:SF23 DOUBLECORTIN DOMAIN CONTAINING 2 DOUBLECORTIN DOMAIN-CONTAINING PROTEIN supramolecular complex#GO:0099080;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185273|UniProtKB=T1FML4 T1FML4 20210063 PTHR12734:SF0 METHYLTRANSFERASE-RELATED 18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED catalytic activity, acting on RNA#GO:0140098;transferase activity#GO:0016740;catalytic activity#GO:0003824;rRNA (guanine) methyltransferase activity#GO:0016435;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on a rRNA#GO:0140102;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;rRNA methyltransferase activity#GO:0008649;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;RNA methyltransferase activity#GO:0008173 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA modification#GO:0009451;rRNA modification#GO:0000154;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;ribosome biogenesis#GO:0042254;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;rRNA methylation#GO:0031167;nucleic acid metabolic process#GO:0090304;methylation#GO:0032259;macromolecule methylation#GO:0043414;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;rRNA base methylation#GO:0070475;RNA methylation#GO:0001510 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 methyltransferase#PC00155;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG73066|UniProtKB=T1G195 T1G195 20214843 PTHR10751:SF29 GUANYLATE BINDING PROTEIN ATLASTIN GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 heterotrimeric G-protein#PC00117;G-protein#PC00020 HELRO|EnsemblGenome=HelroG182816|UniProtKB=T1FIS8 T1FIS8 20208727 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG87192|UniProtKB=T1G6N0 T1G6N0 20216727 PTHR13673:SF0 ESOPHAGEAL CANCER ASSOCIATED PROTEIN VPS35 ENDOSOMAL PROTEIN-SORTING FACTOR-LIKE localization#GO:0051179;endosomal transport#GO:0016197;localization within membrane#GO:0051668;cellular localization#GO:0051641;vesicle-mediated transport to the plasma membrane#GO:0098876;endocytic recycling#GO:0032456;establishment of localization#GO:0051234;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;cellular process#GO:0009987 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG77782|UniProtKB=T1G338 T1G338 20215486 PTHR11267:SF181 T-BOX PROTEIN-RELATED OPTOMOTOR-BLIND PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HELRO|EnsemblGenome=HelroG157878|UniProtKB=T1EMH1 T1EMH1 20197771 PTHR48112:SF32 HIGH MOBILITY GROUP PROTEIN DSP1 HIGH MOBILITY GROUP PROTEIN B3 HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG184655|UniProtKB=T1FLP4 T1FLP4 20209743 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG89736|UniProtKB=T1G7G9 T1G7G9 20217016 PTHR24356:SF210 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE N transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Alzheimer disease-amyloid secretase pathway#P00003>PKC#P00109;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>PKC#P01074 HELRO|EnsemblGenome=HelroG95979|UniProtKB=T1G995 T1G995 20217642 PTHR11680:SF59 SERINE HYDROXYMETHYLTRANSFERASE SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC transferase activity#GO:0016740;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;heterocyclic compound binding#GO:1901363;transferase activity, transferring one-carbon groups#GO:0016741;anion binding#GO:0043168;ion binding#GO:0043167 cellular aromatic compound metabolic process#GO:0006725;organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;heterocycle metabolic process#GO:0046483;proteinogenic amino acid biosynthetic process#GO:0170038;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;folic acid-containing compound metabolic process#GO:0006760;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;organic cyclic compound metabolic process#GO:1901360;alpha-amino acid biosynthetic process#GO:1901607;nitrogen compound metabolic process#GO:0006807;cellular modified amino acid metabolic process#GO:0006575;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;small molecule biosynthetic process#GO:0044283;L-amino acid biosynthetic process#GO:0170034;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 Serine glycine biosynthesis#P02776>Glycine hydroxymethyltransferase#P03158 HELRO|EnsemblGenome=HelroG98827|UniProtKB=T1G9Q0 T1G9Q0 20217796 PTHR10540:SF7 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 endopeptidase complex#GO:1905369;proteasome complex#GO:0000502;peptidase complex#GO:1905368;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;catalytic complex#GO:1902494 translation initiation factor#PC00224;translation factor#PC00223 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489;Cell cycle#P00013>Proteasome#P00480 HELRO|EnsemblGenome=HelroG160962|UniProtKB=T1EQX2 T1EQX2 20198972 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED FMRFAMIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG158818|UniProtKB=T1ENA9 T1ENA9 20198059 PTHR32226:SF2 TELO2-INTERACTING PROTEIN 2 TELO2-INTERACTING PROTEIN 2 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185352|UniProtKB=T1FMQ0 T1FMQ0 20210099 PTHR19139:SF199 AQUAPORIN TRANSPORTER MIP17260P cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG73530|UniProtKB=T1G1F3 T1G1F3 20214901 PTHR45628:SF7 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated calcium channel activity#GO:0005245;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;calcium ion transport#GO:0006816;localization#GO:0051179;calcium ion import#GO:0070509;import across plasma membrane#GO:0098739;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;calcium ion transmembrane import into cytosol#GO:0097553;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657 voltage-gated calcium channel complex#GO:0005891;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;calcium channel complex#GO:0034704;membrane#GO:0016020;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 Ionotropic glutamate receptor pathway#P00037>Ca2+ channel#P01022;Thyrotropin-releasing hormone receptor signaling pathway#P04394>Ca2+ channel#P04587;Metabotropic glutamate receptor group II pathway#P00040>Ca2+#P01051;Metabotropic glutamate receptor group III pathway#P00039>Ca2+#P01041 HELRO|EnsemblGenome=HelroG160833|UniProtKB=T1EQS7 T1EQS7 20198927 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG190525|UniProtKB=T1FS25 T1FS25 20211622 PTHR46275:SF1 HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE protein binding#GO:0005515;ubiquitin-like protein binding#GO:0032182;binding#GO:0005488;ubiquitin binding#GO:0043130 endosomal transport#GO:0016197;localization within membrane#GO:0051668;cellular localization#GO:0051641;vesicle-mediated transport to the plasma membrane#GO:0098876;receptor internalization#GO:0031623;transport#GO:0006810;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;localization#GO:0051179;endocytic recycling#GO:0032456;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;receptor-mediated endocytosis#GO:0006898;intracellular transport#GO:0046907;import into cell#GO:0098657 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;early endosome#GO:0005769;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG161909|UniProtKB=T1ES13 T1ES13 20199363 PTHR45682:SF5 AGAP008228-PA DUAL SPECIFICITY PROTEIN PHOSPHATASE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 regulation of cell communication#GO:0010646;regulation of MAPK cascade#GO:0043408;negative regulation of biological process#GO:0048519;negative regulation of response to stimulus#GO:0048585;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;negative regulation of MAPK cascade#GO:0043409;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of cellular process#GO:0048523;negative regulation of cell communication#GO:0010648 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG161402|UniProtKB=T1ERG0 T1ERG0 20199160 PTHR10696:SF51 GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED TRIMETHYLLYSINE DIOXYGENASE, MITOCHONDRIAL nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;cellular modified amino acid metabolic process#GO:0006575;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 hydroxylase#PC00122 HELRO|EnsemblGenome=HelroG193757|UniProtKB=T1FVB7 T1FVB7 20212763 PTHR14453:SF67 PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN POLY [ADP-RIBOSE] POLYMERASE molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;protein-macromolecule adaptor activity#GO:0030674 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG106804|UniProtKB=T1EE51 T1EE51 20194853 PTHR10343:SF92 5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2 enzyme binding#GO:0019899;protein binding#GO:0005515;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;membrane-bounded organelle#GO:0043227;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695 kinase modulator#PC00140 Gonadotropin-releasing hormone receptor pathway#P06664>AMPK#P06830;p53 pathway by glucose deprivation#P04397>AMPK#P04639 HELRO|EnsemblGenome=HelroG151217|UniProtKB=T1EKI9 T1EKI9 20197089 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG183403|UniProtKB=T1FJK8 T1FJK8 20209007 PTHR12242:SF45 OS02G0130600 PROTEIN-RELATED MARVEL DOMAIN-CONTAINING PROTEIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG189685|UniProtKB=T1FR92 T1FR92 20211339 PTHR10825:SF72 RING FINGER DOMAIN-CONTAINING, POLYCOMB GROUP COMPONENT UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN protein-containing complex binding#GO:0044877;binding#GO:0005488;chromatin binding#GO:0003682 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;PcG protein complex#GO:0031519;protein-containing complex#GO:0032991;PRC1 complex#GO:0035102;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG112113|UniProtKB=T1EFH1 T1EFH1 20195323 PTHR12195:SF0 CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED CYTOPLASMIC FMR1-INTERACTING PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;RNA cap binding#GO:0000339;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;developmental process#GO:0032502;cell morphogenesis#GO:0000902;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;anatomical structure morphogenesis#GO:0009653;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 Huntington disease#P00029>p53#P00797 HELRO|EnsemblGenome=HelroG104662|UniProtKB=T1EDM8 T1EDM8 20194680 PTHR12096:SF0 NUCLEAR PROTEIN SKIP-RELATED SNW DOMAIN-CONTAINING PROTEIN 1 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG179010|UniProtKB=T1FE19 T1FE19 20207068 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185285|UniProtKB=T1FML9 T1FML9 20210068 PTHR43157:SF73 PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED WW DOMAIN-CONTAINING OXIDOREDUCTASE-LIKE PROTEIN glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG165185|UniProtKB=T1EWE5 T1EWE5 20200895 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180188|UniProtKB=T1FFK1 T1FFK1 20207600 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG75097|UniProtKB=T1G205 T1G205 20215103 PTHR10715:SF0 60S RIBOSOMAL PROTEIN L6 LARGE RIBOSOMAL SUBUNIT PROTEIN EL6 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular component biogenesis#GO:0044085;peptide metabolic process#GO:0006518;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;ribosomal large subunit biogenesis#GO:0042273;translation#GO:0006412;protein-RNA complex assembly#GO:0022618;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;ribosomal large subunit assembly#GO:0000027;ribosome biogenesis#GO:0042254;non-membrane-bounded organelle assembly#GO:0140694;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cytoplasmic translation#GO:0002181;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;peptide biosynthetic process#GO:0043043;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;ribonucleoprotein complex biogenesis#GO:0022613;protein-RNA complex organization#GO:0071826 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG194976|UniProtKB=T1FWM3 T1FWM3 20213218 PTHR19441:SF95 WHEY ACDIC PROTEIN WAP PERLWAPIN ISOFORM X1 peptidase inhibitor activity#GO:0030414;molecular function regulator activity#GO:0098772;serine-type endopeptidase inhibitor activity#GO:0004867;peptidase regulator activity#GO:0061134;enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;endopeptidase regulator activity#GO:0061135;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG159741|UniProtKB=T1EPC9 T1EPC9 20198429 PTHR23423:SF21 ORGANIC SOLUTE TRANSPORTER-RELATED ORGANIC SOLUTE TRANSPORTER SUBUNIT ALPHA-LIKE localization#GO:0051179;establishment of localization#GO:0051234;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG166723|UniProtKB=T1EYF6 T1EYF6 20201606 PTHR21704:SF18 NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED NIPPED-B-LIKE PROTEIN protein-containing complex binding#GO:0044877;binding#GO:0005488;chromatin binding#GO:0003682 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;cellular localization#GO:0051641;double-strand break repair#GO:0006302;macromolecule localization#GO:0033036;cell cycle process#GO:0022402;nucleobase-containing compound metabolic process#GO:0006139;mitotic cell cycle process#GO:1903047;establishment of protein localization#GO:0045184;sister chromatid cohesion#GO:0007062;DNA damage response#GO:0006974;mitotic cell cycle#GO:0000278;organic cyclic compound metabolic process#GO:1901360;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;recombinational repair#GO:0000725;protein localization to organelle#GO:0033365;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;mitotic sister chromatid cohesion#GO:0007064;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;double-strand break repair via homologous recombination#GO:0000724;DNA recombination#GO:0006310;protein localization#GO:0008104;primary metabolic process#GO:0044238;replication-born double-strand break repair via sister chromatid exchange#GO:1990414;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;cellular macromolecule localization#GO:0070727;response to stress#GO:0006950;organelle organization#GO:0006996;chromosome organization#GO:0051276;cell cycle#GO:0007049;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG84303|UniProtKB=T1G5H3 T1G5H3 20216320 PTHR47980:SF19 LD44762P RAS-RELATED PROTEIN RAB-3 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;cytoskeletal protein binding#GO:0008092;myosin binding#GO:0017022;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;ribonucleoside triphosphate phosphatase activity#GO:0017111 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;protein secretion#GO:0009306;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;establishment of protein localization to extracellular region#GO:0035592;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;protein transport#GO:0015031;protein localization to extracellular region#GO:0071692;export from cell#GO:0140352;secretion by cell#GO:0032940 presynapse#GO:0098793;synapse#GO:0045202;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;secretory vesicle#GO:0099503;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG109972|UniProtKB=T1EEY0 T1EEY0 20195132 PTHR45840:SF2 RHOMBOID-RELATED PROTEIN PROTEIN RHOMBOID-RELATED HELRO|EnsemblGenome=HelroG183435|UniProtKB=T1FJN2 T1FJN2 20209031 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163441|UniProtKB=T1EU20 T1EU20 20200070 PTHR46077:SF5 E3 UBIQUITIN-PROTEIN LIGASE TOPORS RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein monoubiquitination#GO:0006513;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191982|UniProtKB=T1FTH4 T1FTH4 20212121 PTHR12607:SF12 ADENOMATOUS POLYPOSIS COLI PROTEIN FAMILY APC-LIKE, ISOFORM A-RELATED cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488;beta-catenin binding#GO:0008013 regulation of microtubule-based process#GO:0032886;negative regulation of protein depolymerization#GO:1901880;negative regulation of biological process#GO:0048519;developmental process#GO:0032502;regulation of signaling#GO:0023051;regulation of cellular component organization#GO:0051128;nervous system development#GO:0007399;regulation of biological process#GO:0050789;cell fate specification#GO:0001708;system development#GO:0048731;cell differentiation#GO:0030154;regulation of cytoskeleton organization#GO:0051493;regulation of signal transduction#GO:0009966;negative regulation of organelle organization#GO:0010639;regulation of microtubule cytoskeleton organization#GO:0070507;negative regulation of protein-containing complex disassembly#GO:0043242;negative regulation of cellular component organization#GO:0051129;pattern specification process#GO:0007389;negative regulation of cell communication#GO:0010648;negative regulation of cellular process#GO:0048523;cellular developmental process#GO:0048869;regulation of cell communication#GO:0010646;negative regulation of response to stimulus#GO:0048585;regulation of organelle organization#GO:0033043;multicellular organism development#GO:0007275;negative regulation of signaling#GO:0023057;cell motility#GO:0048870;regulation of protein-containing complex disassembly#GO:0043244;cell fate commitment#GO:0045165;regulation of microtubule polymerization or depolymerization#GO:0031110;cellular process#GO:0009987;regulation of canonical Wnt signaling pathway#GO:0060828;negative regulation of supramolecular fiber organization#GO:1902904;regulation of response to stimulus#GO:0048583;regulation of supramolecular fiber organization#GO:1902903;regulation of protein depolymerization#GO:1901879;regulation of cellular process#GO:0050794;regulation of Wnt signaling pathway#GO:0030111;anatomical structure development#GO:0048856;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;negative regulation of signal transduction#GO:0009968;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of canonical Wnt signaling pathway#GO:0090090;cell migration#GO:0016477;negative regulation of cytoskeleton organization#GO:0051494 supramolecular complex#GO:0099080;membrane protein complex#GO:0098796;catalytic complex#GO:1902494;plasma membrane protein complex#GO:0098797;cytoplasmic microtubule#GO:0005881;supramolecular fiber#GO:0099512;cell periphery#GO:0071944;supramolecular polymer#GO:0099081;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;membrane#GO:0016020;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;extrinsic component of membrane#GO:0019898;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;cytoskeleton#GO:0005856;microtubule#GO:0005874;plasma membrane#GO:0005886 Wnt signaling pathway#P00057>APC#P01468;Angiogenesis#P00005>APC#P00195 HELRO|EnsemblGenome=HelroG125965|UniProtKB=T1EH79 T1EH79 20195929 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG184057|UniProtKB=T1FKI0 T1FKI0 20209329 PTHR11782:SF83 ADENOSINE/GUANOSINE DIPHOSPHATASE GUANOSINE-DIPHOSPHATASE pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;nucleoside diphosphate phosphatase activity#GO:0017110;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;nucleoside phosphate catabolic process#GO:1901292;heterocycle catabolic process#GO:0046700;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleoside diphosphate catabolic process#GO:0009134;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate catabolic process#GO:0046434;phosphate-containing compound metabolic process#GO:0006796;cellular nitrogen compound catabolic process#GO:0044270;aromatic compound catabolic process#GO:0019439;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;organic cyclic compound catabolic process#GO:1901361;catabolic process#GO:0009056;nucleoside diphosphate metabolic process#GO:0009132;organophosphate metabolic process#GO:0019637;organic substance catabolic process#GO:1901575;nucleobase-containing compound catabolic process#GO:0034655;small molecule metabolic process#GO:0044281;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248 cellular anatomical entity#GO:0110165;membrane#GO:0016020 metabolite interconversion enzyme#PC00262;phosphatase#PC00181;nucleotide phosphatase#PC00173 HELRO|EnsemblGenome=HelroG194679|UniProtKB=T1FWB1 T1FWB1 20213107 PTHR12106:SF27 SORTILIN RELATED SORTILIN-RELATED RECEPTOR membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG109381|UniProtKB=T1EET0 T1EET0 20195082 PTHR13055:SF12 TUMOR ENDOTHELIAL MARKER 7 RELATED LD40707P HELRO|EnsemblGenome=HelroG64745|UniProtKB=T1FXY4 T1FXY4 20213682 PTHR24089:SF57 SOLUTE CARRIER FAMILY 25 FI05451P carbohydrate derivative transmembrane transporter activity#GO:1901505;purine nucleotide transmembrane transporter activity#GO:0015216;nucleobase-containing compound transmembrane transporter activity#GO:0015932;transmembrane transporter activity#GO:0022857;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215 localization#GO:0051179;organic substance transport#GO:0071702;organophosphate ester transport#GO:0015748;establishment of localization#GO:0051234;organic anion transport#GO:0015711;nucleobase-containing compound transport#GO:0015931;transport#GO:0006810;nitrogen compound transport#GO:0071705;carbohydrate derivative transport#GO:1901264 mitochondrial carrier protein#PC00158;secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG194758|UniProtKB=T1FWD6 T1FWD6 20213131 PTHR11689:SF136 CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER H(+)_CL(-) EXCHANGE TRANSPORTER 7 inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG186191|UniProtKB=T1FNS7 T1FNS7 20210474 PTHR10501:SF13 U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A nucleic acid binding#GO:0003676;RNA binding#GO:0003723;snRNA binding#GO:0017069;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;U1 snRNP#GO:0005685;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 mRNA splicing#P00058>U2#P01478;mRNA splicing#P00058>U1#P01479 HELRO|EnsemblGenome=HelroG192192|UniProtKB=T1FTP1 T1FTP1 20212188 PTHR46004:SF3 CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 Transcription regulation by bZIP transcription factor#P00055>CREB#P01383;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CREB#P00713 HELRO|EnsemblGenome=HelroG69441|UniProtKB=T1FZV4 T1FZV4 20214352 PTHR11599:SF10 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT ALPHA TYPE-3 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 peptidase complex#GO:1905368;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;proteasome complex#GO:0000502;endopeptidase complex#GO:1905369;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protease#PC00190;protein modifying enzyme#PC00260 Parkinson disease#P00049>20S proteasome#P01227 HELRO|EnsemblGenome=HelroG83772|UniProtKB=T1G5A0 T1G5A0 20216247 PTHR24205:SF16 FOUR AND A HALF LIM DOMAINS PROTEIN GH01042P-RELATED transcription cofactor#PC00217 Angiogenesis#P00005>Paxillin#P00194;VEGF signaling pathway#P00056>Paxillin#P01418 HELRO|EnsemblGenome=HelroG172775|UniProtKB=T1F5X5 T1F5X5 20204224 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG63271|UniProtKB=T1FXD3 T1FXD3 20217407 PTHR23431:SF3 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 5'-3' RNA polymerase activity#GO:0034062;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;zinc ion binding#GO:0008270;transition metal ion binding#GO:0046914;nucleotidyltransferase activity#GO:0016779;RNA polymerase activity#GO:0097747;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;metal ion binding#GO:0046872;catalytic activity, acting on RNA#GO:0140098;cation binding#GO:0043169;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;transferase activity#GO:0016740;ion binding#GO:0043167 DNA metabolism protein#PC00009 Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388 HELRO|EnsemblGenome=HelroG66622|UniProtKB=T1FYN2 T1FYN2 20213930 PTHR10024:SF344 SYNAPTOTAGMIN SYNAPTOTAGMIN-7 cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;phosphatidylserine binding#GO:0001786;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;protein binding#GO:0005515;clathrin binding#GO:0030276;lipid binding#GO:0008289;ion binding#GO:0043167;phospholipid binding#GO:0005543;SNARE binding#GO:0000149 vesicle fusion#GO:0006906;cellular localization#GO:0051641;synaptic vesicle cycle#GO:0099504;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;regulated exocytosis#GO:0045055;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;secretion#GO:0046903;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;signal release#GO:0023061;vesicle organization#GO:0016050;calcium-ion regulated exocytosis#GO:0017156;signaling#GO:0023052;cell-cell signaling#GO:0007267;synaptic vesicle exocytosis#GO:0016079;organelle fusion#GO:0048284;secretion by cell#GO:0032940;neurotransmitter secretion#GO:0007269;trans-synaptic signaling#GO:0099537;vesicle-mediated transport#GO:0016192;cell communication#GO:0007154;cellular component organization#GO:0016043;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;membrane fusion#GO:0061025;signal release from synapse#GO:0099643;exocytosis#GO:0006887;organelle organization#GO:0006996;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;export from cell#GO:0140352;vesicle-mediated transport in synapse#GO:0099003 synapse#GO:0045202;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;axon#GO:0030424;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;neuron projection#GO:0043005;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;transport vesicle#GO:0030133;cell projection#GO:0042995;secretory vesicle#GO:0099503;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG182051|UniProtKB=T1FHN5 T1FHN5 20208334 PTHR19282:SF534 TETRASPANIN TETRASPANIN FAMILY-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG162133|UniProtKB=T1ES98 T1ES98 20199448 PTHR23167:SF88 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG140014|UniProtKB=T1EIZ7 T1EIZ7 20196547 PTHR19134:SF449 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE 1 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG67348|UniProtKB=T1FZ00 T1FZ00 20214048 PTHR14226:SF29 NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER NEUROPATHY TARGET ESTERASE SWS esterase#PC00097;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG192800|UniProtKB=T1FUB2 T1FUB2 20212408 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG120487|UniProtKB=T1EGQ1 T1EGQ1 20195751 PTHR23337:SF3 ZINC FINGER CW-TYPE COILED-COIL DOMAIN PROTEIN 1 MORC FAMILY CW-TYPE ZINC FINGER 2 HELRO|EnsemblGenome=HelroG184490|UniProtKB=T1FLB2 T1FLB2 20209611 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183367|UniProtKB=T1FJI7 T1FJI7 20208986 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG69169|UniProtKB=T1FZQ4 T1FZQ4 20214302 PTHR13275:SF4 YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG185962|UniProtKB=T1FNH8 T1FNH8 20210375 PTHR24250:SF50 CHYMOTRYPSIN-RELATED PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG171205|UniProtKB=T1F3X8 T1F3X8 20203527 PTHR24104:SF57 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED BEE-MILK PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG64425|UniProtKB=T1FXU5 T1FXU5 20213643 PTHR15938:SF0 TBP-1 INTERACTING PROTEIN HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG nucleic acid binding#GO:0003676;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234 cellular aromatic compound metabolic process#GO:0006725;homologous chromosome segregation#GO:0045143;nuclear division#GO:0000280;cell cycle process#GO:0022402;nucleobase-containing compound metabolic process#GO:0006139;chromosome segregation#GO:0007059;reciprocal homologous recombination#GO:0140527;chromosome organization involved in meiotic cell cycle#GO:0070192;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;meiotic cell cycle process#GO:1903046;meiosis I cell cycle process#GO:0061982;reciprocal meiotic recombination#GO:0007131;reproductive process#GO:0022414;meiosis I#GO:0007127;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;nuclear chromosome segregation#GO:0098813;macromolecule metabolic process#GO:0043170;meiotic cell cycle#GO:0051321;homologous chromosome pairing at meiosis#GO:0007129;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;meiotic chromosome segregation#GO:0045132;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;reproduction#GO:0000003;organelle organization#GO:0006996;chromosome organization#GO:0051276;meiotic nuclear division#GO:0140013;sexual reproduction#GO:0019953;cell cycle#GO:0007049;organelle fission#GO:0048285;homologous recombination#GO:0035825;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;condensed chromosome#GO:0000793;intracellular organelle lumen#GO:0070013;condensed nuclear chromosome#GO:0000794;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981 DNA metabolism protein#PC00009 General transcription by RNA polymerase I#P00022>SL1 complex#P00653;General transcription by RNA polymerase I#P00022>TBP#P00657;General transcription regulation#P00023>TBP#P00670;Transcription regulation by bZIP transcription factor#P00055>TBP#P01399 HELRO|EnsemblGenome=HelroG168939|UniProtKB=T1F159 T1F159 20202559 PTHR11991:SF0 TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG170389|UniProtKB=T1F2Z8 T1F2Z8 20203197 PTHR10024:SF234 SYNAPTOTAGMIN SYNAPTOTAGMIN-15-RELATED cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;phosphatidylserine binding#GO:0001786;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;protein binding#GO:0005515;clathrin binding#GO:0030276;lipid binding#GO:0008289;ion binding#GO:0043167;phospholipid binding#GO:0005543;SNARE binding#GO:0000149 localization#GO:0051179;regulated exocytosis#GO:0045055;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;calcium-ion regulated exocytosis#GO:0017156;export from cell#GO:0140352;secretion by cell#GO:0032940 intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;secretory vesicle#GO:0099503;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG168487|UniProtKB=T1F0M5 T1F0M5 20202375 PTHR33844:SF1 SULFOTRANSFER_1 DOMAIN-CONTAINING PROTEIN SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG103700|UniProtKB=T1EDG9 T1EDG9 20194621 PTHR24089:SF57 SOLUTE CARRIER FAMILY 25 FI05451P carbohydrate derivative transmembrane transporter activity#GO:1901505;purine nucleotide transmembrane transporter activity#GO:0015216;nucleobase-containing compound transmembrane transporter activity#GO:0015932;transmembrane transporter activity#GO:0022857;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215 localization#GO:0051179;organic substance transport#GO:0071702;organophosphate ester transport#GO:0015748;establishment of localization#GO:0051234;organic anion transport#GO:0015711;nucleobase-containing compound transport#GO:0015931;transport#GO:0006810;nitrogen compound transport#GO:0071705;carbohydrate derivative transport#GO:1901264 mitochondrial carrier protein#PC00158;secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG191087|UniProtKB=T1FSK7 T1FSK7 20211804 PTHR11528:SF44 HEAT SHOCK PROTEIN 90 FAMILY MEMBER HEAT SHOCK PROTEIN 75 KDA, MITOCHONDRIAL-RELATED enzyme binding#GO:0019899;protein binding#GO:0005515;protein kinase binding#GO:0019901;unfolded protein binding#GO:0051082;binding#GO:0005488;kinase binding#GO:0019900 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein folding#GO:0006457;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;organelle inner membrane#GO:0019866;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227 Hsp90 family chaperone#PC00028 HELRO|EnsemblGenome=HelroG181949|UniProtKB=T1FHH8 T1FHH8 20208277 PTHR13720:SF33 WD-40 REPEAT PROTEIN HELP DOMAIN-CONTAINING PROTEIN cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG189133|UniProtKB=T1FQP8 T1FQP8 20211145 PTHR24408:SF58 ZINC FINGER PROTEIN TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG176291|UniProtKB=T1FAD4 T1FAD4 20205783 PTHR23107:SF34 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN HTH LA-TYPE RNA-BINDING DOMAIN-CONTAINING PROTEIN transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG165248|UniProtKB=T1EWH8 T1EWH8 20200928 PTHR34491:SF137 A-TYPE INCLUSION PROTEIN, PUTATIVE-RELATED AGL058CP HELRO|EnsemblGenome=HelroG185750|UniProtKB=T1FN87 T1FN87 20210285 PTHR24096:SF422 LONG-CHAIN-FATTY-ACID--COA LIGASE BCDNA.GH02901 ligase activity#GO:0016874;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 metabolite interconversion enzyme#PC00262;ligase#PC00142 HELRO|EnsemblGenome=HelroG66915|UniProtKB=T1FYS8 T1FYS8 20213976 PTHR11461:SF211 SERINE PROTEASE INHIBITOR, SERPIN GH10112P-RELATED protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG89490|UniProtKB=T1G7D4 T1G7D4 20216981 PTHR23147:SF189 SERINE/ARGININE RICH SPLICING FACTOR SERINE AND ARGININE-RICH-SPLICING FACTOR 3A nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;nuclear speck#GO:0016607;organelle#GO:0043226;nuclear body#GO:0016604;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG192040|UniProtKB=T1FTJ2 T1FTJ2 20212139 PTHR11923:SF110 SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1 SCAVENGER RECEPTOR CLASS B MEMBER 1 cargo receptor activity#GO:0038024 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG114601|UniProtKB=T1EG34 T1EG34 20195536 PTHR24276:SF91 POLYSERASE-RELATED AT26814P-RELATED hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG69833|UniProtKB=T1FZY8 T1FZY8 20214386 PTHR24543:SF334 MULTICOPPER OXIDASE-RELATED F5_8 TYPE C DOMAIN-CONTAINING PROTEIN oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG159498|UniProtKB=T1EP36 T1EP36 20198336 PTHR45961:SF6 IP21249P IP21249P Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG189220|UniProtKB=T1FQT4 T1FQT4 20211181 PTHR46077:SF5 E3 UBIQUITIN-PROTEIN LIGASE TOPORS RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein monoubiquitination#GO:0006513;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG188188|UniProtKB=T1FPR4 T1FPR4 20210811 PTHR18866:SF33 CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED ligase#PC00142 Methylmalonyl pathway#P02755>Propionyl-CoA carboxylase#P03033 HELRO|EnsemblGenome=HelroG177644|UniProtKB=T1FC00 T1FC00 20206349 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cell communication#GO:0007154;cellular process#GO:0009987;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;Notch signaling pathway#GO:0007219 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG168949|UniProtKB=T1F165 T1F165 20202565 PTHR22806:SF0 NUCLEOPORIN NUP37 P37 -RELATED NUCLEOPORIN NUP37 envelope#GO:0031975;nuclear pore#GO:0005643;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG175357|UniProtKB=T1F968 T1F968 20205367 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164469|UniProtKB=T1EVG5 T1EVG5 20200565 PTHR22763:SF162 RING ZINC FINGER PROTEIN TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG82977|UniProtKB=T1G4Y7 T1G4Y7 20216135 PTHR42884:SF23 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED FURIN-LIKE PROTEASE 2 hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 bounding membrane of organelle#GO:0098588;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791;Golgi membrane#GO:0000139 serine protease#PC00203;protein modifying enzyme#PC00260 Endothelin signaling pathway#P00019>furin#P00575;Alzheimer disease-presenilin pathway#P00004>Furin#P00157;Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105 HELRO|EnsemblGenome=HelroG108226|UniProtKB=T1EEH2 T1EEH2 20194974 PTHR12858:SF1 RIBOSOME BIOGENESIS PROTEIN PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG snoRNA binding#GO:0030515;GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;nucleic acid binding#GO:0003676;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;RNA binding#GO:0003723;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;anion binding#GO:0043168;ion binding#GO:0043167 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;ribosome biogenesis#GO:0042254;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274 preribosome, small subunit precursor#GO:0030688;ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG78131|UniProtKB=T1G385 T1G385 20215533 PTHR24256:SF470 TRYPTASE-RELATED INACTIVE CLIP DOMAIN-CONTAINING SERINE PROTEASE A30 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG73535|UniProtKB=T1G1F4 T1G1F4 20214902 PTHR21148:SF11 THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9 THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule-based process#GO:0007017;organelle organization#GO:0006996 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG116409|UniProtKB=T1EGE6 T1EGE6 20195648 PTHR11208:SF125 RNA-BINDING PROTEIN RELATED KH DOMAIN-CONTAINING RNA-BINDING PROTEIN QKI nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of RNA splicing#GO:0043484;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of mRNA processing#GO:0050684;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;regulation of mRNA metabolic process#GO:1903311 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG76346|UniProtKB=T1G2I6 T1G2I6 20215284 PTHR23349:SF112 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST 48 RELATED 1, ISOFORM B sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG186285|UniProtKB=T1FNX1 T1FNX1 20210518 PTHR11977:SF130 VILLIN SEVERIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;actin polymerization or depolymerization#GO:0008154;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG190918|UniProtKB=T1FSF1 T1FSF1 20211748 PTHR11361:SF35 DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER DNA MISMATCH REPAIR PROTEIN MSH2 nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;mismatch repair#GO:0006298;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mitotic recombination#GO:0006312;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG186036|UniProtKB=T1FNK6 T1FNK6 20210403 PTHR12266:SF0 NA+/CA2+ K+ INDEPENDENT EXCHANGER MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075 localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG178406|UniProtKB=T1FD46 T1FD46 20206745 PTHR21443:SF0 CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 7 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 7 localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;Golgi organization#GO:0007030;establishment of localization#GO:0051234;organelle organization#GO:0006996;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;transport#GO:0006810;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;vesicle tethering complex#GO:0099023;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;Golgi transport complex#GO:0017119;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG194221|UniProtKB=T1FVT9 T1FVT9 20212935 PTHR34930:SF2 GEO05313P1 MICROTUBULE-ASSOCIATED PROTEIN JUPITER cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG155129|UniProtKB=T1FME7 T1FME7 20197421 PTHR11937:SF532 ACTIN ACTIN, CYTOPLASMIC intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 actin and actin related protein#PC00039;cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Alzheimer disease-presenilin pathway#P00004>actin#P00114;Nicotinic acetylcholine receptor signaling pathway#P00044>Actin#P01090;Huntington disease#P00029>Actin#P00807;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>F-actin#P00858;Cadherin signaling pathway#P00012>F-actin#P00470;Cytoskeletal regulation by Rho GTPase#P00016>Actin#P00512 HELRO|EnsemblGenome=HelroG180419|UniProtKB=T1FFW8 T1FFW8 20207717 PTHR23202:SF124 WASP INTERACTING PROTEIN-RELATED C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG67096|UniProtKB=T1FYW2 T1FYW2 20214010 PTHR21328:SF2 POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP16 HELRO|EnsemblGenome=HelroG84805|UniProtKB=T1G5N8 T1G5N8 20216385 PTHR11306:SF68 NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 2 lipid binding#GO:0008289;binding#GO:0005488;organic cyclic compound binding#GO:0097159;steroid binding#GO:0005496;sterol binding#GO:0032934 localization#GO:0051179;organic hydroxy compound transport#GO:0015850;organic substance transport#GO:0071702;establishment of localization#GO:0051234;macromolecule localization#GO:0033036;sterol transport#GO:0015918;transport#GO:0006810;lipid localization#GO:0010876;lipid transport#GO:0006869 HELRO|EnsemblGenome=HelroG78359|UniProtKB=T1G3A9 T1G3A9 20215557 PTHR11824:SF5 VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT CA2+-CHANNEL-PROTEIN-BETA-SUBUNIT, ISOFORM L calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated calcium channel activity#GO:0005245;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;regulation of metal ion transport#GO:0010959;trans-synaptic signaling#GO:0099537;regulation of calcium ion transport#GO:0051924;regulation of localization#GO:0032879;regulation of monoatomic cation transmembrane transport#GO:1904062;cellular component organization#GO:0016043;cell communication#GO:0007154;cellular process#GO:0009987;neuromuscular junction development#GO:0007528;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;synapse organization#GO:0050808;regulation of transport#GO:0051049;chemical synaptic transmission#GO:0007268;anterograde trans-synaptic signaling#GO:0098916;regulation of molecular function#GO:0065009;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;biological regulation#GO:0065007;synaptic signaling#GO:0099536;regulation of monoatomic ion transmembrane transporter activity#GO:0032412;regulation of monoatomic ion transport#GO:0043269;regulation of transmembrane transporter activity#GO:0022898;regulation of transporter activity#GO:0032409;cell-cell signaling#GO:0007267;signaling#GO:0023052 voltage-gated calcium channel complex#GO:0005891;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;calcium channel complex#GO:0034704;membrane#GO:0016020;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227;voltage-gated ion channel#PC00241 Thyrotropin-releasing hormone receptor signaling pathway#P04394>Ca2+ channel#P04587 HELRO|EnsemblGenome=HelroG178772|UniProtKB=T1FDQ1 T1FDQ1 20206950 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG182825|UniProtKB=T1FIT4 T1FIT4 20208733 PTHR11360:SF260 MONOCARBOXYLATE TRANSPORTER MFS DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;monocarboxylic acid transmembrane transporter activity#GO:0008028;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;monocarboxylic acid transport#GO:0015718;establishment of localization#GO:0051234;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942 transporter#PC00227 HELRO|EnsemblGenome=HelroG84028|UniProtKB=T1G5D5 T1G5D5 20216282 PTHR14027:SF2 RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG basal RNA polymerase II transcription machinery binding#GO:0001099;RNA polymerase binding#GO:0070063;binding#GO:0005488;RNA polymerase core enzyme binding#GO:0043175;RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515;enzyme binding#GO:0019899;basal transcription machinery binding#GO:0001098 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;DNA-templated transcription elongation#GO:0006354;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nucleobase-containing compound biosynthetic process#GO:0034654;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;transcription elongation by RNA polymerase II#GO:0006368;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;transcription elongation factor complex#GO:0008023;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase II, holoenzyme#GO:0016591;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;Cdc73/Paf1 complex#GO:0016593;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG181747|UniProtKB=T1FHA0 T1FHA0 20208199 PTHR10513:SF15 DEOXYNUCLEOSIDE KINASE NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 10, MITOCHONDRIAL transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301 mitochondrial ATP synthesis coupled electron transport#GO:0042775;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;mitochondrial electron transport, NADH to ubiquinone#GO:0006120;respiratory electron transport chain#GO:0022904;aerobic electron transport chain#GO:0019646;oxidative phosphorylation#GO:0006119;generation of precursor metabolites and energy#GO:0006091;electron transport chain#GO:0022900;ATP synthesis coupled electron transport#GO:0042773;cellular metabolic process#GO:0044237;cellular process#GO:0009987;energy derivation by oxidation of organic compounds#GO:0015980;metabolic process#GO:0008152 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transporter complex#GO:1990351;oxidoreductase complex#GO:1990204;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;respirasome#GO:0070469;mitochondrial respiratory chain complex I#GO:0005747;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;mitochondrial respirasome#GO:0005746;transmembrane transporter complex#GO:1902495;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;respiratory chain complex I#GO:0045271;NADH dehydrogenase complex#GO:0030964;mitochondrial protein-containing complex#GO:0098798 nucleotide kinase#PC00172 HELRO|EnsemblGenome=HelroG164523|UniProtKB=T1EVI8 T1EVI8 20200588 PTHR32026:SF10 METHYLTRANSFERASE-LIKE PROTEIN 24 METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG175718|UniProtKB=T1F9K1 T1F9K1 20205500 PTHR12673:SF241 FACIOGENITAL DYSPLASIA PROTEIN DH DOMAIN-CONTAINING PROTEIN nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cell projection organization#GO:0030030;organelle organization#GO:0006996;filopodium assembly#GO:0046847;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG166935|UniProtKB=T1EYS0 T1EYS0 20201720 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182204|UniProtKB=T1FHX4 T1FHX4 20208423 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG174218|UniProtKB=T1F7T7 T1F7T7 20204886 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG87627|UniProtKB=T1G6T2 T1G6T2 20216779 PTHR12211:SF0 ENDOPLASMIC RETICULUM PROTEIN ERP29 ENDOPLASMIC RETICULUM RESIDENT PROTEIN 29 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG62778|UniProtKB=T1FX52 T1FX52 20213400 PTHR11042:SF183 EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 negative regulation of biological process#GO:0048519;macromolecule modification#GO:0043412;protein modification process#GO:0036211;negative regulation of cell cycle process#GO:0010948;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;nitrogen compound metabolic process#GO:0006807;reproductive process#GO:0022414;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;negative regulation of cellular process#GO:0048523;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;regulation of cell cycle G2/M phase transition#GO:1902749;negative regulation of cell cycle G2/M phase transition#GO:1902750;negative regulation of cell cycle#GO:0045786;macromolecule metabolic process#GO:0043170;meiotic cell cycle#GO:0051321;negative regulation of cell cycle phase transition#GO:1901988;regulation of cell cycle phase transition#GO:1901987;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;cellular process#GO:0009987;regulation of cell cycle process#GO:0010564;primary metabolic process#GO:0044238;reproduction#GO:0000003;regulation of cellular process#GO:0050794;regulation of meiotic cell cycle#GO:0051445;sexual reproduction#GO:0019953;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;cell cycle#GO:0007049 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG193792|UniProtKB=T1FVC9 T1FVC9 20212775 PTHR23280:SF25 4.1 G PROTEIN MOESIN_EZRIN_RADIXIN HOMOLOG 1 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;actomyosin structure organization#GO:0031032;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG174730|UniProtKB=T1F8E9 T1F8E9 20205098 PTHR14663:SF2 METHYLTRANSFERASE NSUN7-RELATED METHYLTRANSFERASE NSUN7-RELATED HELRO|EnsemblGenome=HelroG188577|UniProtKB=T1FQ52 T1FQ52 20210949 PTHR24189:SF50 MYOTROPHIN ANKYRIN REPEAT AND SOCS BOX PROTEIN 2 HELRO|EnsemblGenome=HelroG186181|UniProtKB=T1FNS2 T1FNS2 20210469 PTHR22599:SF1 MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB MOB-LIKE PROTEIN PHOCEIN cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 kinase modulator#PC00140;kinase activator#PC00138 HELRO|EnsemblGenome=HelroG194540|UniProtKB=T1FW64 T1FW64 20213060 PTHR47020:SF1 HILLARIN HILLARIN HELRO|EnsemblGenome=HelroG175930|UniProtKB=T1F9X1 T1F9X1 20205620 PTHR36191:SF10 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG170101|UniProtKB=T1F2M5 T1F2M5 20203074 PTHR15082:SF2 NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrial respiratory chain complex I assembly#GO:0032981;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;mitochondrion organization#GO:0007005;cellular process#GO:0009987 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transporter complex#GO:1990351;oxidoreductase complex#GO:1990204;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;respirasome#GO:0070469;mitochondrial respiratory chain complex I#GO:0005747;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;mitochondrial respirasome#GO:0005746;transmembrane transporter complex#GO:1902495;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;respiratory chain complex I#GO:0045271;NADH dehydrogenase complex#GO:0030964;mitochondrial protein-containing complex#GO:0098798 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG77502|UniProtKB=T1G2Y8 T1G2Y8 20215436 PTHR47611:SF3 HAT DIMERISATION DOMAIN, C-TERMINAL HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG82715|UniProtKB=T1G4V7 T1G4V7 20216105 PTHR10695:SF46 DEPHOSPHO-COA KINASE-RELATED BIFUNCTIONAL COENZYME A SYNTHASE-RELATED transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 kinase#PC00137 Coenzyme A biosynthesis#P02736>Pantetheine-phosphate adenyltransferase#P02886;Coenzyme A biosynthesis#P02736>Dephospho-CoA kinase#P02884 HELRO|EnsemblGenome=HelroG177065|UniProtKB=T1FB69 T1FB69 20206068 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG76360|UniProtKB=T1G2I9 T1G2I9 20215287 PTHR18945:SF865 NEUROTRANSMITTER GATED ION CHANNEL NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA7, ISOFORM E ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG99625|UniProtKB=T1G9U1 T1G9U1 20217837 PTHR43172:SF1 ADENYLOSUCCINATE LYASE ADENYLOSUCCINATE LYASE lyase activity#GO:0016829;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;purine ribonucleoside monophosphate metabolic process#GO:0009167;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;nucleotide biosynthetic process#GO:0009165;nucleoside monophosphate metabolic process#GO:0009123;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;purine nucleoside monophosphate metabolic process#GO:0009126;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribonucleoside monophosphate metabolic process#GO:0009161;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 lyase#PC00144 De novo purine biosynthesis#P02738>Adenosuccinate lyase#P02901;De novo purine biosynthesis#P02738>5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase#P02892 HELRO|EnsemblGenome=HelroG99557|UniProtKB=T1G9T5 T1G9T5 20217831 PTHR45747:SF4 HISTONE-LYSINE N-METHYLTRANSFERASE E(Z) HISTONE-LYSINE N-METHYLTRANSFERASE E(Z) N-methyltransferase activity#GO:0008170;histone modifying activity#GO:0140993;transferase activity#GO:0016740;binding#GO:0005488;catalytic activity#GO:0003824;histone methyltransferase activity#GO:0042054;chromatin binding#GO:0003682;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;protein-containing complex binding#GO:0044877;protein-lysine N-methyltransferase activity#GO:0016279;catalytic activity, acting on a protein#GO:0140096;lysine N-methyltransferase activity#GO:0016278;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein methyltransferase activity#GO:0008276 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;protein-DNA complex organization#GO:0071824;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;heterochromatin formation#GO:0031507;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;negative regulation of gene expression, epigenetic#GO:0045814;cellular process#GO:0009987;epigenetic regulation of gene expression#GO:0040029;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;heterochromatin organization#GO:0070828;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG193326|UniProtKB=T1FUW1 T1FUW1 20212607 PTHR21331:SF2 BRCA1-ASSOCIATED ATM ACTIVATOR 1 BRCA1-ASSOCIATED ATM ACTIVATOR 1 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;positive regulation of protein modification process#GO:0031401;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;DNA damage response#GO:0006974;positive regulation of metabolic process#GO:0009893;positive regulation of biological process#GO:0048518;positive regulation of protein phosphorylation#GO:0001934;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of phosphorus metabolic process#GO:0010562;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;positive regulation of protein metabolic process#GO:0051247;response to stress#GO:0006950;positive regulation of phosphate metabolic process#GO:0045937;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of protein phosphorylation#GO:0001932;biological regulation#GO:0065007;cellular response to stress#GO:0033554;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG128920|UniProtKB=T1EHQ9 T1EHQ9 20196109 PTHR11849:SF282 ETS ETV5-RELATED PROTEIN ETS96B transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG179787|UniProtKB=T1FF57 T1FF57 20207456 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG160130|UniProtKB=T1EPU5 T1EPU5 20198595 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173054|UniProtKB=T1F6A9 T1F6A9 20204358 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG136381|UniProtKB=T1EID7 T1EID7 20196337 PTHR24637:SF428 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG109536|UniProtKB=T1EEU6 T1EEU6 20195098 PTHR45653:SF10 DEDICATOR OF CYTOKINESIS MYOBLAST CITY, ISOFORM B nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;binding#GO:0005488;molecular function regulator activity#GO:0098772;enzyme binding#GO:0019899;protein binding#GO:0005515;small GTPase binding#GO:0031267;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 Integrin signalling pathway#P00034>Dock180#P00930 HELRO|EnsemblGenome=HelroG89289|UniProtKB=T1G7B4 T1G7B4 20216961 PTHR23032:SF13 BRO1 DOMAIN-CONTAINING PROTEIN BROX BRO1 DOMAIN-CONTAINING PROTEIN BROX HELRO|EnsemblGenome=HelroG167628|UniProtKB=T1EZL0 T1EZL0 20202010 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173440|UniProtKB=T1F6T9 T1F6T9 20204538 PTHR13619:SF0 PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;glycerolipid biosynthetic process#GO:0045017;cardiolipin biosynthetic process#GO:0032049;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;glycerophospholipid metabolic process#GO:0006650;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG169462|UniProtKB=T1F1Z0 T1F1Z0 20202840 PTHR15827:SF2 CYCLIN-DEPENDENT KINASE 2-INTERACTING PROTEIN CYCLIN-DEPENDENT KINASE 2-INTERACTING PROTEIN Cell cycle#P00013>Cdk2#P00485 HELRO|EnsemblGenome=HelroG177789|UniProtKB=T1FC99 T1FC99 20206448 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG173596|UniProtKB=T1F702 T1F702 20204601 PTHR34009:SF2 PROTEIN STAR PROTEIN STAR localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;endosomal transport#GO:0016197;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987 bounding membrane of organelle#GO:0098588;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;late endosome membrane#GO:0031902;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;endosome membrane#GO:0010008;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle membrane#GO:0030659;endoplasmic reticulum#GO:0005783;late endosome#GO:0005770;plasma membrane#GO:0005886;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG191557|UniProtKB=T1FT29 T1FT29 20211976 PTHR14166:SF17 SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN RHO-GAP DOMAIN-CONTAINING PROTEIN GTPase-activating protein#PC00257 PDGF signaling pathway#P00047>Rho#P01174 HELRO|EnsemblGenome=HelroG66323|UniProtKB=T1FYJ8 T1FYJ8 20213896 PTHR43176:SF3 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 oxoacid metabolic process#GO:0043436;branched-chain amino acid metabolic process#GO:0009081;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;amino acid catabolic process#GO:0009063;small molecule catabolic process#GO:0044282;nitrogen compound metabolic process#GO:0006807;alpha-amino acid metabolic process#GO:1901605;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;cellular catabolic process#GO:0044248 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG155661|UniProtKB=T1ELJ9 T1ELJ9 20197449 PTHR11579:SF0 PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE transferase activity#GO:0016740;O-methyltransferase activity#GO:0008171;catalytic activity#GO:0003824;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a protein#GO:0140096;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein methyltransferase activity#GO:0008276 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG170303|UniProtKB=T1F2W5 T1F2W5 20203164 PTHR46345:SF8 INVERTED FORMIN-2 FORMIN 3, ISOFORM B HELRO|EnsemblGenome=HelroG172980|UniProtKB=T1F687 T1F687 20204336 PTHR10030:SF37 ALPHA-L-FUCOSIDASE ALPHA-L-FUCOSIDASE-RELATED hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 monosaccharide metabolic process#GO:0005996;carbohydrate derivative metabolic process#GO:1901135;glycosyl compound catabolic process#GO:1901658;carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;hexose metabolic process#GO:0019318;glycosyl compound metabolic process#GO:1901657;carbohydrate metabolic process#GO:0005975;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;lysosome#GO:0005764;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;vacuole#GO:0005773;cellular anatomical entity#GO:0110165;lytic vacuole#GO:0000323;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosidase#PC00110;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG73300|UniProtKB=T1G1C6 T1G1C6 20214874 PTHR24346:SF42 MAP/MICROTUBULE AFFINITY-REGULATING KINASE SERINE_THREONINE-PROTEIN KINASE SIK3 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;microtubule cytoskeleton organization#GO:0000226;cell communication#GO:0007154;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;regulation of cellular process#GO:0050794;organelle organization#GO:0006996;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;intracellular signal transduction#GO:0035556;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG174248|UniProtKB=T1F7V7 T1F7V7 20204906 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184378|UniProtKB=T1FL32 T1FL32 20209531 PTHR47977:SF12 RAS-RELATED PROTEIN RAB RAS-RELATED PROTEIN RAB-44 GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;transport#GO:0006810 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG164998|UniProtKB=T1EW35 T1EW35 20200785 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG69384|UniProtKB=T1FZU3 T1FZU3 20214341 PTHR12294:SF1 EF HAND DOMAIN FAMILY A1,A2-RELATED CALCIUM UPTAKE PROTEIN 1, MITOCHONDRIAL cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;calcium ion transport#GO:0006816;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;mitochondrial transport#GO:0006839;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation transport#GO:0006812;mitochondrial calcium ion homeostasis#GO:0051560;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;mitochondrial transmembrane transport#GO:1990542;monoatomic cation transmembrane transport#GO:0098655 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;transporter complex#GO:1990351;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;calcium channel complex#GO:0034704;membrane#GO:0016020;organelle envelope#GO:0031967;cation channel complex#GO:0034703;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;mitochondrial envelope#GO:0005740;transmembrane transporter complex#GO:1902495;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;mitochondrial protein-containing complex#GO:0098798 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG164023|UniProtKB=T1EUS5 T1EUS5 20200325 PTHR24243:SF230 G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG91190|UniProtKB=T1G810 T1G810 20217207 PTHR19143:SF444 FIBRINOGEN/TENASCIN/ANGIOPOEITIN PROTEIN SCABROUS external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG191663|UniProtKB=T1FT70 T1FT70 20212017 PTHR15131:SF3 SMALL NUCLEAR RNA ACTIVATING COMPLEX, POLYPEPTIDE 1 SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 1 sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;RNA metabolic process#GO:0016070;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;heterocycle metabolic process#GO:0046483;snRNA metabolic process#GO:0016073;transcription by RNA polymerase III#GO:0006383;snRNA transcription by RNA polymerase II#GO:0042795;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;ncRNA transcription#GO:0098781;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667 HELRO|EnsemblGenome=HelroG113318|UniProtKB=T1EFR6 T1EFR6 20195418 PTHR11434:SF0 NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transporter complex#GO:1990351;oxidoreductase complex#GO:1990204;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;respirasome#GO:0070469;mitochondrial respiratory chain complex I#GO:0005747;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;transmembrane transporter complex#GO:1902495;mitochondrial respirasome#GO:0005746;membrane-bounded organelle#GO:0043227;respiratory chain complex I#GO:0045271;NADH dehydrogenase complex#GO:0030964;mitochondrial protein-containing complex#GO:0098798 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG103786|UniProtKB=T1EDH5 T1EDH5 20194627 PTHR11909:SF428 CASEIN KINASE-RELATED CASEIN KINASE I ISOFORM EPSILON transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of protein metabolic process#GO:0051246;regulation of catabolic process#GO:0009894;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of signal transduction#GO:0009967;regulation of proteolysis involved in protein catabolic process#GO:1903050;positive regulation of proteolysis#GO:0045862;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;regulation of signal transduction#GO:0009966;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;positive regulation of proteolysis involved in protein catabolic process#GO:1903052;macromolecule metabolic process#GO:0043170;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cellular metabolic process#GO:0044237;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;cell communication#GO:0007154;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;positive regulation of canonical Wnt signaling pathway#GO:0090263;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of catabolic process#GO:0009896;positive regulation of protein catabolic process#GO:0045732;import into cell#GO:0098657;regulation of metabolic process#GO:0019222;positive regulation of nitrogen compound metabolic process#GO:0051173;signal transduction#GO:0007165;macromolecule modification#GO:0043412;regulation of signaling#GO:0023051;transport#GO:0006810;positive regulation of proteasomal protein catabolic process#GO:1901800;protein modification process#GO:0036211;regulation of protein catabolic process#GO:0042176;peptidyl-amino acid modification#GO:0018193;positive regulation of Wnt signaling pathway#GO:0030177;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;positive regulation of response to stimulus#GO:0048584;positive regulation of metabolic process#GO:0009893;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;signaling#GO:0023052;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;metabolic process#GO:0008152;regulation of cell communication#GO:0010646;regulation of proteolysis#GO:0030162;cellular response to stimulus#GO:0051716;organonitrogen compound metabolic process#GO:1901564;protein phosphorylation#GO:0006468;cellular process#GO:0009987;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of proteasomal protein catabolic process#GO:0061136;regulation of primary metabolic process#GO:0080090;localization#GO:0051179;response to stimulus#GO:0050896;positive regulation of protein metabolic process#GO:0051247;regulation of macromolecule metabolic process#GO:0060255;regulation of Wnt signaling pathway#GO:0030111;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;CCKR signaling map#P06959>CK1delta/epsilon#P07089;Hedgehog signaling pathway#P00025>Casein kinase I#P00681;Circadian clock system#P00015>Casein kinase I#P00502;Parkinson disease#P00049>Casein kinase I#P01242 HELRO|EnsemblGenome=HelroG158402|UniProtKB=T1EMR6 T1EMR6 20197866 PTHR46103:SF1 RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL catalytic activity, acting on RNA#GO:0140098;transferase activity#GO:0016740;catalytic activity#GO:0003824;rRNA (guanine) methyltransferase activity#GO:0016435;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on a rRNA#GO:0140102;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;rRNA methyltransferase activity#GO:0008649;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;RNA methyltransferase activity#GO:0008173 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA modification#GO:0009451;rRNA modification#GO:0000154;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 RNA metabolism protein#PC00031;RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG109555|UniProtKB=T1EEU8 T1EEU8 20195100 PTHR23420:SF0 ADENOSYLHOMOCYSTEINASE ADENOSYLHOMOCYSTEINASE hydrolase activity#GO:0016787;catalytic activity#GO:0003824 cellular metabolic process#GO:0044237;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG141265|UniProtKB=T1EJ32 T1EJ32 20196582 PTHR10778:SF13 SOLUTE CARRIER FAMILY 35 MEMBER B ADENOSINE 3'-PHOSPHO 5'-PHOSPHOSULFATE TRANSPORTER 1 carbohydrate derivative transmembrane transporter activity#GO:1901505;purine nucleotide transmembrane transporter activity#GO:0015216;nucleobase-containing compound transmembrane transporter activity#GO:0015932;transmembrane transporter activity#GO:0022857;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215 localization#GO:0051179;organic substance transport#GO:0071702;organophosphate ester transport#GO:0015748;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;organic anion transport#GO:0015711;nucleobase-containing compound transport#GO:0015931;transport#GO:0006810;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264 bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;Golgi membrane#GO:0000139;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG178553|UniProtKB=T1FDD1 T1FDD1 20206830 PTHR46927:SF3 AGAP005574-PA THAP-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG116895|UniProtKB=T1EGI4 T1EGI4 20195686 PTHR12640:SF0 RIBOPHORIN II DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 membrane protein complex#GO:0098796;endoplasmic reticulum protein-containing complex#GO:0140534;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;oligosaccharyltransferase complex#GO:0008250;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG165734|UniProtKB=T1EX82 T1EX82 20201182 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG89498|UniProtKB=T1G7D7 T1G7D7 20216984 PTHR45832:SF22 SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED HELRO|EnsemblGenome=HelroG164004|UniProtKB=T1EUR2 T1EUR2 20200312 PTHR32546:SF26 G-PROTEIN COUPLED RECEPTOR 158-RELATED SMOG, ISOFORM D G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG62725|UniProtKB=T1FX41 T1FX41 20213389 PTHR43429:SF2 PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG163469|UniProtKB=T1EU36 T1EU36 20200086 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG83065|UniProtKB=T1G4Z9 T1G4Z9 20216147 PTHR22984:SF29 SERINE/THREONINE-PROTEIN KINASE PIM SERINE_THREONINE-PROTEIN KINASE PIM-1 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG83058|UniProtKB=T1G4Z8 T1G4Z8 20216146 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG161778|UniProtKB=T1ERW7 T1ERW7 20199317 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG172418|UniProtKB=T1F5A8 T1F5A8 20204007 PTHR33273:SF4 DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG66570|UniProtKB=T1FYM7 T1FYM7 20213925 PTHR11081:SF9 FLAP ENDONUCLEASE FAMILY MEMBER FLAP ENDONUCLEASE 1 DNA endonuclease activity#GO:0004520;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824;endonuclease activity#GO:0004519;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097 DNA metabolism protein#PC00009;exodeoxyribonuclease#PC00098 HELRO|EnsemblGenome=HelroG186501|UniProtKB=T1FP03 T1FP03 20210550 PTHR11721:SF3 60S RIBOSOMAL PROTEIN L27A LARGE RIBOSOMAL SUBUNIT PROTEIN UL15 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG185050|UniProtKB=T1FMB9 T1FMB9 20209968 PTHR23061:SF12 DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT DNA POLYMERASE ALPHA SUBUNIT B cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;DNA-templated DNA replication#GO:0006261;DNA replication#GO:0006260;DNA replication initiation#GO:0006270;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;transferase complex#GO:1990234;replisome#GO:0030894;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;DNA polymerase complex#GO:0042575;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;nuclear replication fork#GO:0043596;chromosome#GO:0005694;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513;replication fork#GO:0005657 DNA-directed DNA polymerase#PC00018 HELRO|EnsemblGenome=HelroG184870|UniProtKB=T1FM38 T1FM38 20209887 PTHR10210:SF45 RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 3, CHLOROPLASTIC transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695 nucleotide kinase#PC00172;kinase#PC00137 HELRO|EnsemblGenome=HelroG65174|UniProtKB=T1FY42 T1FY42 20213740 PTHR13318:SF190 PARTNER OF PAIRED, ISOFORM B-RELATED PARTNER OF PAIRED, ISOFORM B macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234 HELRO|EnsemblGenome=HelroG90753|UniProtKB=T1G7V7 T1G7V7 20217154 PTHR10742:SF386 FLAVIN MONOAMINE OXIDASE LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 oxidase#PC00175;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG180499|UniProtKB=T1FFZ7 T1FFZ7 20207746 PTHR21580:SF28 SHIPPO-1-RELATED BOREALIN N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED structural protein#PC00211 HELRO|EnsemblGenome=HelroG182488|UniProtKB=T1FI94 T1FI94 20208543 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179665|UniProtKB=T1FF02 T1FF02 20207401 PTHR24270:SF62 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 apolipoprotein#PC00052 HELRO|EnsemblGenome=HelroG157228|UniProtKB=T1EM86 T1EM86 20197686 PTHR11200:SF257 INOSITOL 5-PHOSPHATASE PHOSPHOINOSITIDE 5-PHOSPHATASE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 lipid metabolic process#GO:0006629;phospholipid dephosphorylation#GO:0046839;phosphatidylinositol dephosphorylation#GO:0046856;cellular metabolic process#GO:0044237;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;lipid modification#GO:0030258;cellular process#GO:0009987;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;dephosphorylation#GO:0016311;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 metabolite interconversion enzyme#PC00262;phosphatase#PC00181 Huntington disease#P00029>Synaptojanin#P00804 HELRO|EnsemblGenome=HelroG176485|UniProtKB=T1FAK4 T1FAK4 20205853 PTHR12766:SF7 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DEATH DOMAIN-ASSOCIATED PROTEIN 6 FAS signaling pathway#P00020>DAXX#P00602;Apoptosis signaling pathway#P00006>DAXX#P00296 HELRO|EnsemblGenome=HelroG77608|UniProtKB=T1G305 T1G305 20215453 PTHR12210:SF171 DULLARD PROTEIN PHOSPHATASE PHOSPHATASE HERZOG hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG115799|UniProtKB=T1EGA6 T1EGA6 20195608 PTHR19981:SF1 TALIN RHEA, ISOFORM B cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;cell-cell adhesion#GO:0098609;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cell adhesion#GO:0007155;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 cytoplasm#GO:0005737;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 Integrin signalling pathway#P00034>Talin#P00943 HELRO|EnsemblGenome=HelroG147997|UniProtKB=T1EK39 T1EK39 20196939 PTHR23235:SF155 KRUEPPEL-LIKE TRANSCRIPTION FACTOR EARLY GROWTH RESPONSE 4-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG87508|UniProtKB=T1G6R2 T1G6R2 20216759 PTHR46010:SF1 PROTEIN IWS1 HOMOLOG PROTEIN IWS1 HOMOLOG poly(A)+ mRNA export from nucleus#GO:0016973;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;mRNA transport#GO:0051028;RNA localization#GO:0006403;localization#GO:0051179;organic substance transport#GO:0071702;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG109994|UniProtKB=T1EEY1 T1EEY1 20195133 PTHR12295:SF30 FURRY-RELATED PROTEIN FURRY cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;developmental process#GO:0032502 cytoplasm#GO:0005737;cell periphery#GO:0071944;cell cortex#GO:0005938;cellular anatomical entity#GO:0110165;site of polarized growth#GO:0030427;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG99395|UniProtKB=T1G9S6 T1G9S6 20217822 PTHR10362:SF7 HISTIDINE AMMONIA-LYASE HISTIDINE AMMONIA-LYASE lyase activity#GO:0016829;catalytic activity#GO:0003824 lyase#PC00144 HELRO|EnsemblGenome=HelroG194277|UniProtKB=T1FVW1 T1FVW1 20212957 PTHR10233:SF14 TRANSLATION INITIATION FACTOR EIF-2B TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG72768|UniProtKB=T1G153 T1G153 20214801 PTHR21236:SF2 GOLGI MEMBRANE PROTEIN YIP1 PROTEIN YIPF endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;vesicle fusion#GO:0006906;cellular localization#GO:0051641;Golgi organization#GO:0007030;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;membrane fusion#GO:0061025;establishment of localization#GO:0051234;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;vesicle organization#GO:0016050;intracellular transport#GO:0046907;organelle fusion#GO:0048284 cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi apparatus subcompartment#GO:0098791;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 structural protein#PC00211 HELRO|EnsemblGenome=HelroG170221|UniProtKB=T1F2S9 T1F2S9 20203128 PTHR12810:SF0 MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29 SMALL RIBOSOMAL SUBUNIT PROTEIN MS29 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;organellar ribosome#GO:0000313;protein-containing complex#GO:0032991;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;small ribosomal subunit#GO:0015935;ribosome#GO:0005840;mitochondrial small ribosomal subunit#GO:0005763;mitochondrial protein-containing complex#GO:0098798 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG153376|UniProtKB=T1EL59 T1EL59 20197309 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG71473|UniProtKB=T1G0M1 T1G0M1 20214619 PTHR12735:SF27 BOLA-LIKE PROTEIN-RELATED BOLA-LIKE PROTEIN 2 small molecule binding#GO:0036094;binding#GO:0005488;iron-sulfur cluster binding#GO:0051536 inorganic ion homeostasis#GO:0098771;intracellular iron ion homeostasis#GO:0006879;intracellular monoatomic cation homeostasis#GO:0030003;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic ion homeostasis#GO:0006873;chemical homeostasis#GO:0048878;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG161346|UniProtKB=T1ERD2 T1ERD2 20199132 PTHR11276:SF28 DNA POLYMERASE TYPE-X FAMILY MEMBER DNA POLYMERASE LAMBDA DNA-directed DNA polymerase activity#GO:0003887;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on DNA#GO:0140097;DNA polymerase activity#GO:0034061 DNA-directed DNA polymerase#PC00018 HELRO|EnsemblGenome=HelroG189938|UniProtKB=T1FRI2 T1FRI2 20211429 PTHR23257:SF958 SERINE-THREONINE PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE WNK4 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG172976|UniProtKB=T1F684 T1F684 20204333 PTHR10015:SF465 HEAT SHOCK TRANSCRIPTION FACTOR HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG71289|UniProtKB=T1G0J0 T1G0J0 20214588 PTHR23327:SF42 RING FINGER PROTEIN 127 LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG86839|UniProtKB=T1G6H9 T1G6H9 20216676 PTHR12119:SF2 UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C CYTOCHROME B-C1 COMPLEX SUBUNIT 8 mitochondrial ATP synthesis coupled electron transport#GO:0042775;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;respiratory electron transport chain#GO:0022904;aerobic electron transport chain#GO:0019646;oxidative phosphorylation#GO:0006119;generation of precursor metabolites and energy#GO:0006091;electron transport chain#GO:0022900;ATP synthesis coupled electron transport#GO:0042773;cellular metabolic process#GO:0044237;mitochondrial electron transport, ubiquinol to cytochrome c#GO:0006122;cellular process#GO:0009987;energy derivation by oxidation of organic compounds#GO:0015980;metabolic process#GO:0008152 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;cytochrome complex#GO:0070069;respiratory chain complex#GO:0098803;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transporter complex#GO:1990351;oxidoreductase complex#GO:1990204;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;respirasome#GO:0070469;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;mitochondrial respirasome#GO:0005746;transmembrane transporter complex#GO:1902495;inner mitochondrial membrane protein complex#GO:0098800;mitochondrial respiratory chain complex III#GO:0005750;membrane-bounded organelle#GO:0043227;mitochondrial protein-containing complex#GO:0098798 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG163285|UniProtKB=T1ETV4 T1ETV4 20200004 PTHR13382:SF69 MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B FI18408P1 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG72429|UniProtKB=T1G0Z9 T1G0Z9 20214747 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;heme binding#GO:0020037 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG172847|UniProtKB=T1F603 T1F603 20204252 PTHR22763:SF190 RING ZINC FINGER PROTEIN RING FINGER PROTEIN 24 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG169113|UniProtKB=T1F1E9 T1F1E9 20202649 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG96714|UniProtKB=T1G9D3 T1G9D3 20217680 PTHR15228:SF24 SPERMATHECAL PHYSIOLOGY VARIANT RHO-GAP DOMAIN-CONTAINING PROTEIN nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;activation of GTPase activity#GO:0090630;biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345 G-protein modulator#PC00022;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG64314|UniProtKB=T1FXS7 T1FXS7 20213625 PTHR11960:SF18 EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B nucleic acid binding#GO:0003676;RNA binding#GO:0003723;translation regulator activity#GO:0045182;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation initiation factor activity#GO:0003743;RNA cap binding#GO:0000339;translation regulator activity, nucleic acid binding#GO:0090079;translation factor activity, RNA binding#GO:0008135 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;translational initiation#GO:0006413;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG185958|UniProtKB=T1FNH6 T1FNH6 20210373 PTHR24056:SF334 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 1 transferase activity#GO:0016740;cyclin-dependent protein kinase activity#GO:0097472;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 negative regulation of biological process#GO:0048519;signal transduction#GO:0007165;DNA damage checkpoint signaling#GO:0000077;mitotic cell cycle phase transition#GO:0044772;macromolecule modification#GO:0043412;mitotic cell cycle checkpoint signaling#GO:0007093;cell cycle process#GO:0022402;protein modification process#GO:0036211;negative regulation of cell cycle process#GO:0010948;mitotic cell cycle process#GO:1903047;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;cell cycle checkpoint signaling#GO:0000075;negative regulation of mitotic cell cycle phase transition#GO:1901991;DNA damage response#GO:0006974;mitotic cell cycle#GO:0000278;nitrogen compound metabolic process#GO:0006807;signal transduction in response to DNA damage#GO:0042770;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular response to stimulus#GO:0051716;regulation of cell cycle G2/M phase transition#GO:1902749;negative regulation of cell cycle G2/M phase transition#GO:1902750;regulation of mitotic cell cycle phase transition#GO:1901990;macromolecule metabolic process#GO:0043170;negative regulation of cell cycle#GO:0045786;regulation of cell cycle phase transition#GO:1901987;negative regulation of cell cycle phase transition#GO:1901988;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;negative regulation of mitotic cell cycle#GO:0045930;cell communication#GO:0007154;cellular process#GO:0009987;cell cycle phase transition#GO:0044770;primary metabolic process#GO:0044238;regulation of cell cycle process#GO:0010564;response to stimulus#GO:0050896;DNA integrity checkpoint signaling#GO:0031570;G2/M transition of mitotic cell cycle#GO:0000086;response to stress#GO:0006950;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;regulation of cellular process#GO:0050794;mitotic G2/M transition checkpoint#GO:0044818;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of G2/M transition of mitotic cell cycle#GO:0010389;mitotic DNA integrity checkpoint signaling#GO:0044774;mitotic G2 DNA damage checkpoint signaling#GO:0007095;cellular response to stress#GO:0033554;mitotic DNA damage checkpoint signaling#GO:0044773;regulation of mitotic cell cycle#GO:0007346;cell cycle G2/M phase transition#GO:0044839 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 p53 pathway#P00059>Cdc2#P04634 HELRO|EnsemblGenome=HelroG190818|UniProtKB=T1FSB5 T1FSB5 20211712 PTHR24370:SF10 OPTICIN LEUCINE-RICH REPEAT AND WD REPEAT-CONTAINING PROTEIN 1 extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG89522|UniProtKB=T1G7E0 T1G7E0 20216987 PTHR13305:SF0 RIBOSOME BIOGENESIS PROTEIN NOP10 H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG166132|UniProtKB=T1EXU0 T1EXU0 20201390 PTHR24054:SF28 CASEIN KINASE II SUBUNIT ALPHA CASEIN KINASE 2 ALPHA 1-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;peptidyl-threonine phosphorylation#GO:0018107;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;regulation of cell cycle#GO:0051726;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;cytosol#GO:0005829;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227 Cadherin signaling pathway#P00012>Casein kinase II#P00462;Wnt signaling pathway#P00057>Casein Kinase 2#P01459;Parkinson disease#P00049>Casein kinase II#P01236 HELRO|EnsemblGenome=HelroG81357|UniProtKB=T1G4D6 T1G4D6 20215934 PTHR14920:SF0 OSMOTIC AVOIDANCE ABNORMAL PROTEIN 1/WD REPEAT MEMBRANE PROTEIN WD REPEAT DOMAIN 19 cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;cilium assembly#GO:0060271;cell projection organization#GO:0030030;transport#GO:0006810;microtubule-based movement#GO:0007018;cellular component organization#GO:0016043;intraciliary retrograde transport#GO:0035721;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;transport along microtubule#GO:0010970;cell projection assembly#GO:0030031;intraciliary transport#GO:0042073;localization#GO:0051179;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based transport#GO:0099111;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;organelle organization#GO:0006996;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;plasma membrane bounded cell projection assembly#GO:0120031;protein-containing complex localization#GO:0031503 protein-containing complex#GO:0032991;intraciliary transport particle A#GO:0030991;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cilium#GO:0005929;intraciliary transport particle#GO:0030990 HELRO|EnsemblGenome=HelroG85703|UniProtKB=T1G619 T1G619 20216516 PTHR23055:SF69 CALCIUM BINDING PROTEINS NEURONAL CALCIUM SENSOR 2 cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG158187|UniProtKB=T1EMK1 T1EMK1 20197801 PTHR20856:SF7 DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;RNA polymerase activity#GO:0097747;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG98781|UniProtKB=T1G9P7 T1G9P7 20217793 PTHR10150:SF0 DNA REPAIR ENDONUCLEASE XPF DNA REPAIR ENDONUCLEASE XPF hydrolase activity, acting on ester bonds#GO:0016788;DNA endonuclease activity#GO:0004520;nucleic acid binding#GO:0003676;nuclease activity#GO:0004518;single-stranded DNA binding#GO:0003697;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;endonuclease activity#GO:0004519;damaged DNA binding#GO:0003684;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on DNA#GO:0140097;DNA nuclease activity#GO:0004536 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;double-strand break repair#GO:0006302;nuclear division#GO:0000280;cell cycle process#GO:0022402;nucleobase-containing compound metabolic process#GO:0006139;reciprocal homologous recombination#GO:0140527;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;interstrand cross-link repair#GO:0036297;nitrogen compound metabolic process#GO:0006807;meiotic cell cycle process#GO:1903046;recombinational repair#GO:0000725;meiosis I cell cycle process#GO:0061982;reciprocal meiotic recombination#GO:0007131;reproductive process#GO:0022414;meiosis I#GO:0007127;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;nucleotide-excision repair#GO:0006289;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;meiotic cell cycle#GO:0051321;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;double-strand break repair via homologous recombination#GO:0000724;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;resolution of meiotic recombination intermediates#GO:0000712;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;reproduction#GO:0000003;organelle organization#GO:0006996;meiotic nuclear division#GO:0140013;sexual reproduction#GO:0019953;cell cycle#GO:0007049;organelle fission#GO:0048285;homologous recombination#GO:0035825;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleotide-excision repair complex#GO:0000109;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 endodeoxyribonuclease#PC00093 HELRO|EnsemblGenome=HelroG86704|UniProtKB=T1G6F7 T1G6F7 20216654 PTHR18945:SF865 NEUROTRANSMITTER GATED ION CHANNEL NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA7, ISOFORM E ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG160227|UniProtKB=T1EQ00 T1EQ00 20198650 PTHR19134:SF562 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE PROTEIN-TYROSINE-PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG193178|UniProtKB=T1FUP8 T1FUP8 20212544 PTHR23309:SF49 3-HYDROXYACYL-COA DEHYROGENASE PEROXISOMAL BIFUNCTIONAL ENZYME oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;lipid oxidation#GO:0034440;cellular metabolic process#GO:0044237;lipid catabolic process#GO:0016042;lipid modification#GO:0030258;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;fatty acid catabolic process#GO:0009062;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;fatty acid metabolic process#GO:0006631;small molecule catabolic process#GO:0044282;fatty acid beta-oxidation#GO:0006635;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;carboxylic acid metabolic process#GO:0019752;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG160942|UniProtKB=T1EQW1 T1EQW1 20198961 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186129|UniProtKB=T1FNP8 T1FNP8 20210445 PTHR10758:SF2 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 peptidase complex#GO:1905368;protein-containing complex#GO:0032991;proteasome accessory complex#GO:0022624;proteasome regulatory particle#GO:0005838;catalytic complex#GO:1902494;proteasome regulatory particle, lid subcomplex#GO:0008541;proteasome complex#GO:0000502;endopeptidase complex#GO:1905369;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 protease#PC00190;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489;Cell cycle#P00013>Proteasome#P00480 HELRO|EnsemblGenome=HelroG113832|UniProtKB=T1EFX2 T1EFX2 20195474 PTHR14140:SF45 E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED RING-TYPE E3 UBIQUITIN TRANSFERASE transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;protein-DNA complex organization#GO:0071824;negative regulation of biological process#GO:0048519;macromolecule modification#GO:0043412;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;regulation of biological process#GO:0050789;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;negative regulation of cellular process#GO:0048523;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;cellular component organization#GO:0016043;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression, epigenetic#GO:0045814;cellular process#GO:0009987;primary metabolic process#GO:0044238;epigenetic regulation of gene expression#GO:0040029;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;protein-containing complex organization#GO:0043933;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG154963|UniProtKB=T1ELG8 T1ELG8 20197418 PTHR23430:SF429 HISTONE H2A HISTONE H2A nucleosome binding#GO:0031491;nucleic acid binding#GO:0003676;chromatin DNA binding#GO:0031490;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;protein-containing complex binding#GO:0044877 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;protein-DNA complex organization#GO:0071824;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;heterochromatin formation#GO:0031507;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;negative regulation of gene expression, epigenetic#GO:0045814;cellular process#GO:0009987;epigenetic regulation of gene expression#GO:0040029;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;heterochromatin organization#GO:0070828;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG191849|UniProtKB=T1FTC5 T1FTC5 20212072 PTHR11905:SF250 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG148469|UniProtKB=T1EK90 T1EK90 20196990 PTHR24333:SF8 HOMEO BOX HB9 LIKE A-RELATED HOMEOBOX PROTEIN CEH-62 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG83563|UniProtKB=T1G573 T1G573 20216221 PTHR20934:SF0 TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG basal RNA polymerase II transcription machinery binding#GO:0001099;RNA polymerase binding#GO:0070063;binding#GO:0005488;RNA polymerase core enzyme binding#GO:0043175;RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515;enzyme binding#GO:0019899;basal transcription machinery binding#GO:0001098 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;DNA-templated transcription elongation#GO:0006354;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nucleobase-containing compound biosynthetic process#GO:0034654;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;transcription elongation by RNA polymerase II#GO:0006368;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 HELRO|EnsemblGenome=HelroG174911|UniProtKB=T1F8L8 T1F8L8 20205167 PTHR46173:SF1 CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL tRNA binding#GO:0000049;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;tRNA metabolic process#GO:0006399;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG185607|UniProtKB=T1FN12 T1FN12 20210211 PTHR13293:SF6 AKIRIN-RELATED AKIRIN-RELATED molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG162528|UniProtKB=T1EST0 T1EST0 20199630 PTHR13710:SF105 DNA HELICASE RECQ FAMILY MEMBER ATP-DEPENDENT DNA HELICASE Q1 ATP-dependent activity, acting on DNA#GO:0008094;3'-5' DNA helicase activity#GO:0043138;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;DNA geometric change#GO:0032392;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;DNA conformation change#GO:0071103;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;response to stress#GO:0006950;organelle organization#GO:0006996;chromosome organization#GO:0051276;nitrogen compound metabolic process#GO:0006807;DNA duplex unwinding#GO:0032508;cellular response to stress#GO:0033554;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;metabolic process#GO:0008152 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;chromosome#GO:0005694;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA helicase#PC00011;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG162221|UniProtKB=T1ESD4 T1ESD4 20199484 PTHR10218:SF329 GTP-BINDING PROTEIN ALPHA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN G(Q) SUBUNIT ALPHA GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;ribonucleoside triphosphate phosphatase activity#GO:0017111;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 regulation of biological process#GO:0050789;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;side of membrane#GO:0098552;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;extrinsic component of membrane#GO:0019898 heterotrimeric G-protein#PC00117;G-protein#PC00020 Endothelin signaling pathway#P00019>Gq#P00586;Metabotropic glutamate receptor group I pathway#P00041>G-Protein#P01057;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>Gqalpha#P05927;Gonadotropin-releasing hormone receptor pathway#P06664>gnaq/11#P06841;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Galphaq#P00826;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Gqalpha#P00732;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;Wnt signaling pathway#P00057>Galpha#P01451;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Galphai/q#P00873;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;PI3 kinase pathway#P00048>Galpha#P01199 HELRO|EnsemblGenome=HelroG94435|UniProtKB=T1G913 T1G913 20217560 PTHR10383:SF9 SERINE INCORPORATOR SERINE INCORPORATOR, ISOFORM F cellular anatomical entity#GO:0110165;membrane#GO:0016020 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG176734|UniProtKB=T1FAU7 T1FAU7 20205946 PTHR23349:SF68 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST FI14601P sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG185133|UniProtKB=T1FMF8 T1FMF8 20210007 PTHR18884:SF69 SEPTIN SEPTIN-RELATED GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 localization#GO:0051179;cell division#GO:0051301;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;cytoskeleton-dependent cytokinesis#GO:0061640;cell cycle process#GO:0022402;cell cycle#GO:0007049;cellular process#GO:0009987;cytokinesis#GO:0000910;protein localization#GO:0008104 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;cell division site#GO:0032153;cell cortex#GO:0005938;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG68857|UniProtKB=T1FZK5 T1FZK5 20214253 PTHR12771:SF51 ENGULFMENT AND CELL MOTILITY LD01482P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG83594|UniProtKB=T1G577 T1G577 20216225 PTHR10257:SF3 SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM protein phosphatase#PC00195;protein modifying enzyme#PC00260 Wnt signaling pathway#P00057>PP2A#P01438;FGF signaling pathway#P00021>PP2A#P00629;EGF receptor signaling pathway#P00018>PP2A#P00547 HELRO|EnsemblGenome=HelroG193918|UniProtKB=T1FVH1 T1FVH1 20212817 PTHR23254:SF15 EIF4G DOMAIN PROTEIN POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 1 nucleic acid binding#GO:0003676;translation regulator activity#GO:0045182;translation regulator activity, nucleic acid binding#GO:0090079;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;regulation of translational initiation#GO:0006446;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG194760|UniProtKB=T1FWD8 T1FWD8 20213133 PTHR42861:SF127 CALCIUM-TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE SARCOPLASMIC_ENDOPLASMIC RETICULUM TYPE calcium ion transmembrane transporter activity#GO:0015085;inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;P-type ion transporter activity#GO:0015662;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;inorganic cation transmembrane transporter activity#GO:0022890;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;calcium ion transport#GO:0006816;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;membrane#GO:0016020 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG168554|UniProtKB=T1F0Q1 T1F0Q1 20202401 PTHR33590:SF1 GLUTENIN, HIGH MOLECULAR WEIGHT SUBUNIT PW212-RELATED PROTEIN PDZ DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG70072|UniProtKB=T1G022 T1G022 20214420 PTHR24343:SF457 SERINE/THREONINE KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG172934|UniProtKB=T1F658 T1F658 20204307 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192918|UniProtKB=T1FUF5 T1FUF5 20212451 PTHR33562:SF28 ATILLA, ISOFORM B-RELATED-RELATED PROTEIN QUIVER HELRO|EnsemblGenome=HelroG179158|UniProtKB=T1FEA1 T1FEA1 20207150 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG188971|UniProtKB=T1FQI7 T1FQI7 20211084 PTHR45943:SF1 E3 UBIQUITIN-PROTEIN LIGASE MYCBP2 E3 UBIQUITIN-PROTEIN LIGASE MYCBP2 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG86763|UniProtKB=T1G6G6 T1G6G6 20216663 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG153248|UniProtKB=T1EL15 T1EL15 20197268 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184835|UniProtKB=T1FM24 T1FM24 20209873 PTHR19877:SF13 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;spliceosomal snRNP assembly#GO:0000387;organic substance metabolic process#GO:0071704;mRNA splicing, via spliceosome#GO:0000398;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375 SMN-Sm protein complex#GO:0034719;cytoplasm#GO:0005737;SMN complex#GO:0032797;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;Sm-like protein family complex#GO:0120114;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG194391|UniProtKB=T1FW03 T1FW03 20212999 PTHR44281:SF2 SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG HELRO|EnsemblGenome=HelroG190054|UniProtKB=T1FRM5 T1FRM5 20211472 PTHR24373:SF370 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN FISH-LIPS, ISOFORM E external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG174450|UniProtKB=T1F850 T1F850 20204999 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG72245|UniProtKB=T1G0X5 T1G0X5 20214723 PTHR48112:SF22 HIGH MOBILITY GROUP PROTEIN DSP1 MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG177865|UniProtKB=T1FCD9 T1FCD9 20206488 PTHR12242:SF45 OS02G0130600 PROTEIN-RELATED MARVEL DOMAIN-CONTAINING PROTEIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG164684|UniProtKB=T1EVQ0 T1EVQ0 20200650 PTHR22906:SF43 PROPERDIN PROPERDIN HELRO|EnsemblGenome=HelroG180860|UniProtKB=T1FGC3 T1FGC3 20207872 PTHR12345:SF16 SYNTENIN RELATED X11L, ISOFORM F-RELATED regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;anterograde trans-synaptic signaling#GO:0098916;biological regulation#GO:0065007;synaptic signaling#GO:0099536;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052;cell-cell signaling#GO:0007267 synapse#GO:0045202;somatodendritic compartment#GO:0036477;cell junction#GO:0030054;dendrite#GO:0030425;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;dendritic tree#GO:0097447;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;neuron projection#GO:0043005;postsynapse#GO:0098794;cell projection#GO:0042995;dendritic spine#GO:0043197;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG109889|UniProtKB=T1EEX1 T1EEX1 20195123 PTHR23323:SF26 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 organelle localization#GO:0051640;transport#GO:0006810;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;exocytic process#GO:0140029;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;endosome organization#GO:0007032;vacuole organization#GO:0007033;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;organelle organization#GO:0006996;vesicle organization#GO:0016050;export from cell#GO:0140352;organelle fusion#GO:0048284;secretion by cell#GO:0032940 membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle tethering complex#GO:0099023;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG174863|UniProtKB=T1F8J9 T1F8J9 20205148 PTHR28589:SF1 28S RIBOSOMAL PROTEIN S34, MITOCHONDRIAL SMALL RIBOSOMAL SUBUNIT PROTEIN MS34 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG161512|UniProtKB=T1ERK6 T1ERK6 20199206 PTHR23325:SF1 SERUM RESPONSE FACTOR-BINDING SERUM RESPONSE FACTOR-BINDING PROTEIN 1 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG178489|UniProtKB=T1FD90 T1FD90 20206789 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG66523|UniProtKB=T1FYM3 T1FYM3 20213921 PTHR24031:SF761 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX49-RELATED RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG89658|UniProtKB=T1G7F6 T1G7F6 20217003 PTHR16318:SF0 GAMMA-SECRETASE SUBUNIT PEN-2 GAMMA-SECRETASE SUBUNIT PEN-2 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;plasma membrane protein complex#GO:0098797;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 Alzheimer disease-amyloid secretase pathway#P00003>Pen-2#P00089;Alzheimer disease-presenilin pathway#P00004>Pen-2#P00149 HELRO|EnsemblGenome=HelroG63300|UniProtKB=T1FXD7 T1FXD7 20213485 PTHR15036:SF85 PIKACHURIN-LIKE PROTEIN SP2353, ISOFORM A cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG130236|UniProtKB=T1EHT4 T1EHT4 20196134 PTHR14009:SF1 LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN intracellular monoatomic cation homeostasis#GO:0030003;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic ion homeostasis#GO:0006873;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG186449|UniProtKB=T1FNZ8 T1FNZ8 20210545 PTHR11606:SF13 GLUTAMATE DEHYDROGENASE GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;dicarboxylic acid metabolic process#GO:0043648;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;amino acid catabolic process#GO:0009063;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;nitrogen compound metabolic process#GO:0006807;glutamate metabolic process#GO:0006536;alpha-amino acid metabolic process#GO:1901605;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;L-amino acid metabolic process#GO:0170033;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152 dehydrogenase#PC00092;oxidoreductase#PC00176 Glutamine glutamate conversion#P02745>Glutamate Dehydrogenase#P02967 HELRO|EnsemblGenome=HelroG172738|UniProtKB=T1F5W2 T1F5W2 20204211 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG156976|UniProtKB=T1EM43 T1EM43 20197643 PTHR19856:SF0 WD-REPEATCONTAINING PROTEIN WDR1 WD REPEAT-CONTAINING PROTEIN 1 cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;cellular component disassembly#GO:0022411;actin filament-based process#GO:0030029;protein-containing complex disassembly#GO:0032984;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;actin polymerization or depolymerization#GO:0008154;cellular component organization#GO:0016043;protein depolymerization#GO:0051261;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;actin filament depolymerization#GO:0030042 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;cell cortex#GO:0005938;cell periphery#GO:0071944;cortical actin cytoskeleton#GO:0030864;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG64519|UniProtKB=T1FXV8 T1FXV8 20213656 PTHR13374:SF3 DET1 HOMOLOG DE-ETIOLATED-1 HOMOLOG DET1 HOMOLOG molecular adaptor activity#GO:0060090;binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389;protein-macromolecule adaptor activity#GO:0030674;protein binding#GO:0005515;ubiquitin ligase-substrate adaptor activity#GO:1990756;enzyme binding#GO:0019899;ubiquitin protein ligase binding#GO:0031625 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of protein metabolic process#GO:0051246;regulation of catabolic process#GO:0009894;macromolecule modification#GO:0043412;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of proteasomal protein catabolic process#GO:1901800;protein modification process#GO:0036211;regulation of protein catabolic process#GO:0042176;regulation of proteolysis involved in protein catabolic process#GO:1903050;post-translational protein modification#GO:0043687;positive regulation of proteolysis#GO:0045862;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;positive regulation of biological process#GO:0048518;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;regulation of proteolysis#GO:0030162;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;positive regulation of proteolysis involved in protein catabolic process#GO:1903052;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;regulation of primary metabolic process#GO:0080090;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of protein metabolic process#GO:0051247;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;positive regulation of catabolic process#GO:0009896;positive regulation of protein catabolic process#GO:0045732;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;regulation of metabolic process#GO:0019222 protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG183634|UniProtKB=T1FJY9 T1FJY9 20209138 PTHR23167:SF82 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG170520|UniProtKB=T1F357 T1F357 20203256 PTHR21622:SF0 COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4 COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4 protein-disulfide reductase activity#GO:0015035;disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;protein transmembrane transport#GO:0071806;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein transmembrane import into intracellular organelle#GO:0044743;establishment of protein localization#GO:0045184;organic substance transport#GO:0071702;establishment of localization#GO:0051234;protein targeting to mitochondrion#GO:0006626;nitrogen compound metabolic process#GO:0006807;protein localization to organelle#GO:0033365;protein metabolic process#GO:0019538;mitochondrial transmembrane transport#GO:1990542;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;macromolecule biosynthetic process#GO:0009059;transmembrane transport#GO:0055085;macromolecule metabolic process#GO:0043170;protein targeting#GO:0006605;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;cellular metabolic process#GO:0044237;establishment of protein localization to organelle#GO:0072594;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein localization to mitochondrion#GO:0070585;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;mitochondrial transport#GO:0006839;cellular macromolecule localization#GO:0070727;establishment of protein localization to mitochondrion#GO:0072655;protein folding#GO:0006457;protein transport#GO:0015031 envelope#GO:0031975;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;mitochondrial envelope#GO:0005740;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;mitochondrial intermembrane space#GO:0005758;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG100017|UniProtKB=T1ECY1 T1ECY1 20194433 PTHR45806:SF1 SYNAPTOBREVIN HOMOLOG YKT6 SYNAPTOBREVIN HOMOLOG YKT6 molecular adaptor activity#GO:0060090;SNAP receptor activity#GO:0005484;protein-macromolecule adaptor activity#GO:0030674 localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG76689|UniProtKB=T1G2M6 T1G2M6 20215324 PTHR44489:SF11 FAMILY NOT NAMED WD REPEAT DOMAIN 86 HELRO|EnsemblGenome=HelroG180768|UniProtKB=T1FG93 T1FG93 20207842 PTHR10627:SF31 SCP160 DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG151058|UniProtKB=T1EKI5 T1EKI5 20197085 PTHR11188:SF17 ARRESTIN DOMAIN CONTAINING PROTEIN FI21816P1 localization#GO:0051179;organic substance transport#GO:0071702;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;protein transport#GO:0015031;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG181386|UniProtKB=T1FGY3 T1FGY3 20208082 PTHR22948:SF29 TUDOR DOMAIN CONTAINING PROTEIN FI02030P-RELATED scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG87801|UniProtKB=T1G6V5 T1G6V5 20216802 PTHR10553:SF2 SMALL NUCLEAR RIBONUCLEOPROTEIN SMALL NUCLEAR RIBONUCLEOPROTEIN G RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;mRNA metabolic process#GO:0016071;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;mRNA splicing, via spliceosome#GO:0000398 supramolecular complex#GO:0099080;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein complex#GO:1990904;ribonucleoprotein granule#GO:0035770;small nuclear ribonucleoprotein complex#GO:0030532;precatalytic spliceosome#GO:0071011;Sm-like protein family complex#GO:0120114;U12-type spliceosomal complex#GO:0005689;catalytic step 2 spliceosome#GO:0071013;nucleus#GO:0005634;catalytic complex#GO:1902494;U1 snRNP#GO:0005685;U4 snRNP#GO:0005687;intracellular anatomical structure#GO:0005622;U5 snRNP#GO:0005682;cytoplasmic ribonucleoprotein granule#GO:0036464;SMN-Sm protein complex#GO:0034719;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;spliceosomal snRNP complex#GO:0097525;protein-containing complex#GO:0032991;U2 snRNP#GO:0005686;U2-type prespliceosome#GO:0071004;spliceosomal tri-snRNP complex#GO:0097526;P granule#GO:0043186;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG182432|UniProtKB=T1FI67 T1FI67 20208516 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG87727|UniProtKB=T1G6U9 T1G6U9 20216796 PTHR11537:SF254 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG184865|UniProtKB=T1FM35 T1FM35 20209884 PTHR11952:SF2 UDP- GLUCOSE PYROPHOSPHORYLASE LD24639P HELRO|EnsemblGenome=HelroG84263|UniProtKB=T1G5G6 T1G5G6 20216313 PTHR12903:SF0 MITOCHONDRIAL RIBOSOMAL PROTEIN L24 LARGE RIBOSOMAL SUBUNIT PROTEIN UL24M macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;translation#GO:0006412;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG183886|UniProtKB=T1FKA4 T1FKA4 20209253 PTHR20948:SF2 TRANSMEMBRANE PROTEIN 164 TRANSMEMBRANE PROTEIN 164 HELRO|EnsemblGenome=HelroG192562|UniProtKB=T1FU30 T1FU30 20212326 PTHR13738:SF1 TROPONIN I TROPONIN I non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG71534|UniProtKB=T1G0M9 T1G0M9 20214627 PTHR12308:SF83 ANOCTAMIN ANOCTAMIN inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216 localization#GO:0051179;inorganic anion transmembrane transport#GO:0098661;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;transport#GO:0006810;chloride transport#GO:0006821;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG90638|UniProtKB=T1G7T7 T1G7T7 20217134 PTHR11575:SF24 5'-NUCLEOTIDASE-RELATED 5'-NUCLEOTIDASE phosphodiesterase#PC00185;metabolite interconversion enzyme#PC00262 Pyrimidine Metabolism#P02771>5'-Nucleotidase#P03131;Purine metabolism#P02769>5'-Nucleotidase#P03119 HELRO|EnsemblGenome=HelroG108980|UniProtKB=T1EEP6 T1EEP6 20195048 PTHR13914:SF0 PROLINE OXIDASE PROLINE DEHYDROGENASE 1, MITOCHONDRIAL oxidase#PC00175;oxidoreductase#PC00176 Huntington disease#P00029>Proline oxidase#G01529 HELRO|EnsemblGenome=HelroG114997|UniProtKB=T1EG57 T1EG57 20195559 PTHR11237:SF4 COENZYME Q10 BIOSYNTHESIS PROTEIN 7 5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL HELRO|EnsemblGenome=HelroG158399|UniProtKB=T1EMR4 T1EMR4 20197864 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161033|UniProtKB=T1ER12 T1ER12 20199012 PTHR11046:SF25 OLIGORIBONUCLEASE, MITOCHONDRIAL SUBFAMILY NOT NAMED endoribonuclease#PC00094;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG174990|UniProtKB=T1F8P7 T1F8P7 20205196 PTHR10166:SF37 VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED STOLID, ISOFORM H ion channel#PC00133;transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG76443|UniProtKB=T1G2J9 T1G2J9 20215297 PTHR45646:SF11 SERINE/THREONINE-PROTEIN KINASE DOA-RELATED SERINE_THREONINE-PROTEIN KINASE DOA transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG159957|UniProtKB=T1EPL5 T1EPL5 20198515 PTHR46600:SF1 THAP DOMAIN-CONTAINING THAP DOMAIN-CONTAINING PROTEIN 1 zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG174896|UniProtKB=T1F8L2 T1F8L2 20205161 PTHR23113:SF99 GUANINE NUCLEOTIDE EXCHANGE FACTOR RASGEF DOMAIN-CONTAINING PROTEIN guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG127888|UniProtKB=T1EHJ5 T1EHJ5 20196045 PTHR13202:SF0 MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT SIGNAL PEPTIDASE COMPLEX SUBUNIT 1 cellular localization#GO:0051641;macromolecule localization#GO:0033036;peptide metabolic process#GO:0006518;gene expression#GO:0010467;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;protein processing#GO:0016485;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein localization to organelle#GO:0033365;establishment of protein localization to endoplasmic reticulum#GO:0072599;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;protein localization to endoplasmic reticulum#GO:0070972;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein targeting#GO:0006605;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;establishment of protein localization to organelle#GO:0072594;protein targeting to ER#GO:0045047;protein maturation#GO:0051604;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;cellular macromolecule localization#GO:0070727;signal peptide processing#GO:0006465 membrane protein complex#GO:0098796;peptidase complex#GO:1905368;endoplasmic reticulum protein-containing complex#GO:0140534;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 protease#PC00190;protein modifying enzyme#PC00260 Vasopressin synthesis#P04395>Signal Peptidase#P04589 HELRO|EnsemblGenome=HelroG177905|UniProtKB=T1FCG2 T1FCG2 20206511 PTHR13270:SF14 PROTEIN C20ORF116-RELATED SEX DETERMINATION AND DOSAGE COMPENSATION PROTEIN SDC-2 HELRO|EnsemblGenome=HelroG174494|UniProtKB=T1F868 T1F868 20205017 PTHR18934:SF83 ATP-DEPENDENT RNA HELICASE PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640 ribonucleoprotein complex#GO:1990904;catalytic step 2 spliceosome#GO:0071013;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG174875|UniProtKB=T1F8K1 T1F8K1 20205150 PTHR46515:SF1 TATA ELEMENT MODULATORY FACTOR TMF1 TATA ELEMENT MODULATORY FACTOR cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG86199|UniProtKB=T1G683 T1G683 20216580 PTHR11461:SF211 SERINE PROTEASE INHIBITOR, SERPIN GH10112P-RELATED protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG104598|UniProtKB=T1EDM5 T1EDM5 20194677 PTHR15592:SF18 MATRIN 3/NUCLEAR PROTEIN 220-RELATED SMOOTH, ISOFORM T nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nitrogen compound metabolic process#GO:0051171;regulation of biosynthetic process#GO:0009889;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG156911|UniProtKB=T1EM31 T1EM31 20197631 PTHR11808:SF15 TRANS-SULFURATION ENZYME FAMILY MEMBER CYSTATHIONINE GAMMA-LYASE small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;lyase activity#GO:0016829;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;sulfur compound metabolic process#GO:0006790;proteinogenic amino acid biosynthetic process#GO:0170038;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;alpha-amino acid biosynthetic process#GO:1901607;nitrogen compound metabolic process#GO:0006807;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;small molecule biosynthetic process#GO:0044283;L-amino acid biosynthetic process#GO:0170034;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 lyase#PC00144 Methionine biosynthesis#P02753>O-Succinyl homoserine lyase#P03026 HELRO|EnsemblGenome=HelroG112074|UniProtKB=T1EFG7 T1EFG7 20195319 PTHR11827:SF6 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS SOLUTE CARRIER FAMILY 12 MEMBER 8 inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium ion transmembrane transporter activity#GO:0015079;symporter activity#GO:0015293;chloride transmembrane transporter activity#GO:0015108;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 inorganic ion homeostasis#GO:0098771;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;inorganic anion transmembrane transport#GO:0098661;import across plasma membrane#GO:0098739;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;inorganic anion transport#GO:0015698;potassium ion transport#GO:0006813;regulation of anatomical structure size#GO:0090066;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;monoatomic anion transmembrane transport#GO:0098656;chloride transport#GO:0006821;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;cellular component organization#GO:0016043;cellular process#GO:0009987;chemical homeostasis#GO:0048878;regulation of cellular component size#GO:0032535;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;regulation of cell size#GO:0008361;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;potassium ion import across plasma membrane#GO:1990573 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG108581|UniProtKB=T1EEK5 T1EEK5 20195007 PTHR45929:SF3 JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG110065|UniProtKB=T1EEZ0 T1EEZ0 20195142 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG94863|UniProtKB=T1G936 T1G936 20217583 PTHR45721:SF11 LAMIN DM0-RELATED LAMIN DM0-RELATED FAS signaling pathway#P00020>Nuclear Lamin#P00616 HELRO|EnsemblGenome=HelroG89387|UniProtKB=T1G7C6 T1G7C6 20216973 PTHR48021:SF1 FAMILY NOT NAMED GH07001P-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG79715|UniProtKB=T1G3S6 T1G3S6 20215724 PTHR45667:SF9 S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN MITOCHONDRIAL S-ADENOSYLMETHIONINE CARRIER PROTEIN transmembrane transporter activity#GO:0022857;organic cation transmembrane transporter activity#GO:0015101;transporter activity#GO:0005215 envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227 mitochondrial carrier protein#PC00158;secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG188886|UniProtKB=T1FQF7 T1FQF7 20211054 PTHR16206:SF4 DEP DOMAIN-CONTAINING PROTEIN LET-99 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG132940|UniProtKB=T1EI00 T1EI00 20196200 PTHR45911:SF4 C2 DOMAIN-CONTAINING PROTEIN MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG181133|UniProtKB=T1FGN3 T1FGN3 20207982 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166157|UniProtKB=T1EXU8 T1EXU8 20201398 PTHR15375:SF26 ACTIVATOR OF S-PHASE KINASE-RELATED PROTEIN CHIFFON protein kinase activator activity#GO:0030295;protein kinase regulator activity#GO:0019887;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;kinase regulator activity#GO:0019207;kinase activator activity#GO:0019209 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA metabolic process#GO:0051052;positive regulation of cellular metabolic process#GO:0031325;regulation of cell cycle phase transition#GO:1901987;positive regulation of cell cycle#GO:0045787;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;regulation of cell cycle process#GO:0010564;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cell cycle process#GO:0090068;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622 kinase modulator#PC00140;kinase activator#PC00138 HELRO|EnsemblGenome=HelroG153307|UniProtKB=T1EL30 T1EL30 20197280 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170223|UniProtKB=T1F2T1 T1F2T1 20203130 PTHR13582:SF0 M-PHASE PHOSPHOPROTEIN 6 M-PHASE PHOSPHOPROTEIN 6 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;rRNA metabolic process#GO:0016072;nitrogen compound metabolic process#GO:0006807;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of 5.8S rRNA#GO:0000460;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 HELRO|EnsemblGenome=HelroG70304|UniProtKB=T1G042 T1G042 20214440 PTHR14200:SF11 CYTOCHROME C OXIDASE POLYPEPTIDE CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL mitochondrial ATP synthesis coupled electron transport#GO:0042775;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;respiratory electron transport chain#GO:0022904;aerobic electron transport chain#GO:0019646;oxidative phosphorylation#GO:0006119;generation of precursor metabolites and energy#GO:0006091;electron transport chain#GO:0022900;ATP synthesis coupled electron transport#GO:0042773;cellular metabolic process#GO:0044237;cellular process#GO:0009987;mitochondrial electron transport, cytochrome c to oxygen#GO:0006123;energy derivation by oxidation of organic compounds#GO:0015980;metabolic process#GO:0008152 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;cytochrome complex#GO:0070069;respiratory chain complex#GO:0098803;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;respirasome#GO:0070469;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;mitochondrial respirasome#GO:0005746;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;respiratory chain complex IV#GO:0045277;mitochondrial protein-containing complex#GO:0098798 oxidase#PC00175;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG167361|UniProtKB=T1EZA9 T1EZA9 20201909 PTHR23334:SF69 CCAAT/ENHANCER BINDING PROTEIN CCAAT_ENHANCER-BINDING PROTEIN GAMMA sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 DNA-binding transcription factor#PC00218;basic leucine zipper transcription factor#PC00056 HELRO|EnsemblGenome=HelroG175148|UniProtKB=T1F8X2 T1F8X2 20205271 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77014|UniProtKB=T1G2S4 T1G2S4 20215372 PTHR13180:SF2 SMALL MEMBRANE PROTEIN-RELATED TRANSMEMBRANE PROTEIN 50B endosomal transport#GO:0016197;establishment of protein localization to vacuole#GO:0072666;cellular localization#GO:0051641;macromolecule localization#GO:0033036;protein targeting to vacuole#GO:0006623;vacuolar transport#GO:0007034;transport#GO:0006810;protein localization to vacuole#GO:0072665;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;protein targeting#GO:0006605;nitrogen compound transport#GO:0071705;late endosome to vacuole transport#GO:0045324;establishment of protein localization to organelle#GO:0072594;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;endosome transport via multivesicular body sorting pathway#GO:0032509;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;protein localization to organelle#GO:0033365;intracellular transport#GO:0046907 HELRO|EnsemblGenome=HelroG141072|UniProtKB=T1EJ24 T1EJ24 20196574 PTHR22807:SF4 NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING 28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA modification#GO:0009451;rRNA modification#GO:0000154;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;ribosome biogenesis#GO:0042254;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;rRNA methylation#GO:0031167;nucleic acid metabolic process#GO:0090304;methylation#GO:0032259;macromolecule methylation#GO:0043414;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;rRNA base methylation#GO:0070475;RNA methylation#GO:0001510 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG168135|UniProtKB=T1F076 T1F076 20202226 PTHR46680:SF3 NF-KAPPA-B INHIBITOR ALPHA NF-KAPPA-B INHIBITOR CACTUS Toll pathway-drosophila#P06217>CACT#P06342 HELRO|EnsemblGenome=HelroG189957|UniProtKB=T1FRJ1 T1FRJ1 20211438 PTHR11731:SF202 PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED DIPEPTIDYL PEPTIDASE FAMILY MEMBER 2 hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG181166|UniProtKB=T1FGP7 T1FGP7 20207996 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163643|UniProtKB=T1EUB0 T1EUB0 20200160 PTHR19282:SF562 TETRASPANIN AT12771P-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG181450|UniProtKB=T1FH08 T1FH08 20208107 PTHR47246:SF1 MUCIN-19 MUCIN-19 HELRO|EnsemblGenome=HelroG155930|UniProtKB=T1ELP3 T1ELP3 20197493 PTHR24078:SF553 DNAJ HOMOLOG SUBFAMILY C MEMBER DNAJ HOMOLOG SUBFAMILY B MEMBER 5 protein binding#GO:0005515;protein-folding chaperone binding#GO:0051087;unfolded protein binding#GO:0051082;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;chaperone-mediated protein folding#GO:0061077;chaperone cofactor-dependent protein refolding#GO:0051085;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;'de novo' protein folding#GO:0006458;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG184981|UniProtKB=T1FM80 T1FM80 20209929 PTHR12620:SF8 U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT U2 SMALL NUCLEAR RNA AUXILIARY FACTOR 1 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;pre-mRNA binding#GO:0036002;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG172478|UniProtKB=T1F5D5 T1F5D5 20204034 PTHR44809:SF1 FAMILY NOT NAMED PROTEIN O-MANNOSYL-TRANSFERASE TMTC1 HELRO|EnsemblGenome=HelroG170990|UniProtKB=T1F3N7 T1F3N7 20203436 PTHR11782:SF83 ADENOSINE/GUANOSINE DIPHOSPHATASE GUANOSINE-DIPHOSPHATASE pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;nucleoside diphosphate phosphatase activity#GO:0017110;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;nucleoside phosphate catabolic process#GO:1901292;heterocycle catabolic process#GO:0046700;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleoside diphosphate catabolic process#GO:0009134;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate catabolic process#GO:0046434;phosphate-containing compound metabolic process#GO:0006796;cellular nitrogen compound catabolic process#GO:0044270;aromatic compound catabolic process#GO:0019439;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;organic cyclic compound catabolic process#GO:1901361;catabolic process#GO:0009056;nucleoside diphosphate metabolic process#GO:0009132;organophosphate metabolic process#GO:0019637;organic substance catabolic process#GO:1901575;nucleobase-containing compound catabolic process#GO:0034655;small molecule metabolic process#GO:0044281;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248 cellular anatomical entity#GO:0110165;membrane#GO:0016020 metabolite interconversion enzyme#PC00262;phosphatase#PC00181;nucleotide phosphatase#PC00173 HELRO|EnsemblGenome=HelroG159887|UniProtKB=T1EPI1 T1EPI1 20198481 PTHR21004:SF0 SERINE PROTEASE-RELATED PEROXISOMAL LEADER PEPTIDE-PROCESSING PROTEASE hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;microbody#GO:0042579;membrane-bounded organelle#GO:0043227;peroxisome#GO:0005777;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG78428|UniProtKB=T1G3B6 T1G3B6 20215564 PTHR24253:SF153 TRANSMEMBRANE PROTEASE SERINE SERINE PROTEASE HEPSIN serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG164908|UniProtKB=T1EVY5 T1EVY5 20200735 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180357|UniProtKB=T1FFT5 T1FFT5 20207684 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG104383|UniProtKB=T1EDL3 T1EDL3 20194665 PTHR46315:SF1 SPERMINE SYNTHASE SPERMINE SYNTHASE transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824 amine metabolic process#GO:0009308;biogenic amine metabolic process#GO:0006576;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;polyamine metabolic process#GO:0006595;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;polyamine biosynthetic process#GO:0006596;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG178217|UniProtKB=T1FCY4 T1FCY4 20206683 PTHR46704:SF9 CXC DOMAIN-CONTAINING PROTEIN-RELATED BHLH DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG70793|UniProtKB=T1G0C2 T1G0C2 20214520 PTHR10412:SF11 MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;glucosidase activity#GO:0015926;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 glucosidase#PC00108;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG161404|UniProtKB=T1ERG1 T1ERG1 20199161 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cell communication#GO:0007154;cellular process#GO:0009987;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;Notch signaling pathway#GO:0007219 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG192899|UniProtKB=T1FUE3 T1FUE3 20212439 PTHR11905:SF159 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG190574|UniProtKB=T1FS39 T1FS39 20211636 PTHR24044:SF502 NOTCH LIGAND FAMILY MEMBER ANTERIOR PHARYNX IN EXCESS PROTEIN 1-RELATED protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG71229|UniProtKB=T1G0I1 T1G0I1 20214579 PTHR12586:SF1 CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG105910|UniProtKB=T1EDY5 T1EDY5 20194787 PTHR14237:SF19 MOLYBDOPTERIN COFACTOR SULFURASE MOSC MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 1 HELRO|EnsemblGenome=HelroG168778|UniProtKB=T1F0Y4 T1F0Y4 20202484 PTHR24403:SF48 ZINC FINGER PROTEIN PR DOMAIN ZINC FINGER PROTEIN 10 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG86747|UniProtKB=T1G6G3 T1G6G3 20216660 PTHR31308:SF3 FAMILY NOT NAMED ENDOGLYCOCERAMIDASE HELRO|EnsemblGenome=HelroG103762|UniProtKB=T1EDH3 T1EDH3 20194625 PTHR12509:SF8 SPERMATOGENESIS-ASSOCIATED 4-RELATED SPERMATOGENESIS-ASSOCIATED PROTEIN 4 cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 biological regulation#GO:0065007;regulation of biological process#GO:0050789;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of organelle organization#GO:0033043 axoneme#GO:0005930;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;plasma membrane bounded cell projection cytoplasm#GO:0032838;ciliary plasm#GO:0097014;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cytoskeleton#GO:0005856;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG175375|UniProtKB=T1F975 T1F975 20205374 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG88252|UniProtKB=T1G706 T1G706 20216853 PTHR12510:SF4 TROPONIN C-AKIN-1 PROTEIN GAMMA-GLUTAMYLAMINECYCLOTRANSFERASE cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185207|UniProtKB=T1FMI4 T1FMI4 20210033 PTHR45769:SF3 ADENOSINE KINASE ADENOSINE KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;purine nucleobase metabolic process#GO:0006144;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase metabolic process#GO:0009112;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG66057|UniProtKB=T1FYG5 T1FYG5 20213863 PTHR11830:SF0 40S RIBOSOMAL PROTEIN S3A SMALL RIBOSOMAL SUBUNIT PROTEIN ES1 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG183804|UniProtKB=T1FK78 T1FK78 20209227 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG122772|UniProtKB=T1EGV8 T1EGV8 20195808 PTHR12210:SF171 DULLARD PROTEIN PHOSPHATASE PHOSPHATASE HERZOG hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG188966|UniProtKB=T1FQI6 T1FQI6 20211083 PTHR46510:SF1 BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA metabolic process#GO:0051052;positive regulation of cellular metabolic process#GO:0031325;regulation of cellular component organization#GO:0051128;regulation of RNA biosynthetic process#GO:2001141;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;biological regulation#GO:0065007;regulation of chromatin organization#GO:1902275;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG77403|UniProtKB=T1G2X1 T1G2X1 20215419 PTHR11908:SF132 XANTHINE DEHYDROGENASE ALDEHYDE OXIDASE 1-RELATED oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 oxidoreductase#PC00176 Adenine and hypoxanthine salvage pathway#P02723>Xanthine dehydrogenase#P02809;Purine metabolism#P02769>Xanthine Oxidase#P03116 HELRO|EnsemblGenome=HelroG71169|UniProtKB=T1G0H3 T1G0H3 20214571 PTHR24205:SF4 FOUR AND A HALF LIM DOMAINS PROTEIN PROTEIN ESPINAS molecular adaptor activity#GO:0060090;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;protein-macromolecule adaptor activity#GO:0030674 supramolecular complex#GO:0099080;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;Z disc#GO:0030018;cellular anatomical entity#GO:0110165;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;contractile fiber#GO:0043292;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;sarcomere#GO:0030017;membrane-bounded organelle#GO:0043227;myofibril#GO:0030016;I band#GO:0031674 transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG108202|UniProtKB=T1EEG8 T1EEG8 20194970 PTHR21347:SF0 CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED LIPID SCRAMBLASE CLPTM1L cellular anatomical entity#GO:0110165;membrane#GO:0016020;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG85680|UniProtKB=T1G615 T1G615 20216512 PTHR24333:SF8 HOMEO BOX HB9 LIKE A-RELATED HOMEOBOX PROTEIN CEH-62 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG179833|UniProtKB=T1FF71 T1FF71 20207470 PTHR22776:SF49 MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN MARVEL DOMAIN-CONTAINING PROTEIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG81208|UniProtKB=T1G4B3 T1G4B3 20215911 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG105256|UniProtKB=T1EDS4 T1EDS4 20194726 PTHR10972:SF200 OXYSTEROL-BINDING PROTEIN-RELATED OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 9 binding#GO:0005488;organic cyclic compound binding#GO:0097159;sterol transporter activity#GO:0015248;steroid binding#GO:0005496;sterol binding#GO:0032934;lipid binding#GO:0008289;lipid transporter activity#GO:0005319;transporter activity#GO:0005215 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG171263|UniProtKB=T1F403 T1F403 20203552 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192479|UniProtKB=T1FU01 T1FU01 20212297 PTHR15228:SF24 SPERMATHECAL PHYSIOLOGY VARIANT RHO-GAP DOMAIN-CONTAINING PROTEIN nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;activation of GTPase activity#GO:0090630;biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345 G-protein modulator#PC00022;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG165386|UniProtKB=T1EWP6 T1EWP6 20200996 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN SI:DKEY-17M8.2 HELRO|EnsemblGenome=HelroG70084|UniProtKB=T1G025 T1G025 20214423 PTHR10110:SF126 SODIUM/HYDROGEN EXCHANGER NA(+)_H(+) EXCHANGER PROTEIN 7 secondary active transmembrane transporter activity#GO:0015291;inorganic molecular entity transmembrane transporter activity#GO:0015318;antiporter activity#GO:0015297;transmembrane transporter activity#GO:0022857;potassium ion transmembrane transporter activity#GO:0015079;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;proton transmembrane transporter activity#GO:0015078;metal cation:proton antiporter activity#GO:0051139;active monoatomic ion transmembrane transporter activity#GO:0022853;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;inorganic cation transmembrane transporter activity#GO:0022890;transporter activity#GO:0005215 regulation of intracellular pH#GO:0051453;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;regulation of pH#GO:0006885;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;regulation of cellular pH#GO:0030641;import into cell#GO:0098657;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG68987|UniProtKB=T1FZN1 T1FZN1 20214279 PTHR12829:SF7 N6-ADENOSINE-METHYLTRANSFERASE N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT RNA metabolism protein#PC00031;RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG72919|UniProtKB=T1G172 T1G172 20214820 PTHR11006:SF10 PROTEIN ARGININE N-METHYLTRANSFERASE HISTONE-ARGININE METHYLTRANSFERASE CARMER-RELATED N-methyltransferase activity#GO:0008170;histone modifying activity#GO:0140993;transferase activity#GO:0016740;catalytic activity#GO:0003824;histone methyltransferase activity#GO:0042054;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a protein#GO:0140096;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein methyltransferase activity#GO:0008276 protein-DNA complex organization#GO:0071824;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular component organization#GO:0016043;peptidyl-amino acid modification#GO:0018193;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;methylation#GO:0032259;macromolecule methylation#GO:0043414;nitrogen compound metabolic process#GO:0006807;protein-containing complex organization#GO:0043933;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG145234|UniProtKB=T1EJJ5 T1EJJ5 20196745 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG130575|UniProtKB=T1EHU3 T1EHU3 20196143 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;chloride transmembrane transporter activity#GO:0015108;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;inorganic anion transmembrane transport#GO:0098661;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic anion transport#GO:0006820;chloride transport#GO:0006821;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;inorganic anion transport#GO:0015698 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG173599|UniProtKB=T1F705 T1F705 20204604 PTHR34009:SF2 PROTEIN STAR PROTEIN STAR localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;endosomal transport#GO:0016197;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987 bounding membrane of organelle#GO:0098588;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;late endosome membrane#GO:0031902;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;endosome membrane#GO:0010008;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle membrane#GO:0030659;endoplasmic reticulum#GO:0005783;late endosome#GO:0005770;plasma membrane#GO:0005886;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG185956|UniProtKB=T1FNH4 T1FNH4 20210371 PTHR23055:SF69 CALCIUM BINDING PROTEINS NEURONAL CALCIUM SENSOR 2 cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG184823|UniProtKB=T1FM19 T1FM19 20209868 PTHR11071:SF559 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;catalytic activity#GO:0003824;amide binding#GO:0033218;peptide binding#GO:0042277 macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein peptidyl-prolyl isomerization#GO:0000413;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;protein modification process#GO:0036211;gene expression#GO:0010467;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein folding#GO:0006457;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG159976|UniProtKB=T1EPM1 T1EPM1 20198521 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG70715|UniProtKB=T1G0B1 T1G0B1 20214509 PTHR43963:SF4 CARBONYL REDUCTASE 1-RELATED CARBONYL REDUCTASE (NADPH) oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG174937|UniProtKB=T1F8M9 T1F8M9 20205178 PTHR21538:SF24 ANILLIN/RHOTEKIN RTKN PH DOMAIN-CONTAINING PROTEIN cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG93668|UniProtKB=T1G8X3 T1G8X3 20217520 PTHR12307:SF53 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT phosphatase binding#GO:0019902;enzyme binding#GO:0019899;protein binding#GO:0005515;carbohydrate binding#GO:0030246;protein phosphatase binding#GO:0019903;binding#GO:0005488 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein serine/threonine phosphatase complex#GO:0008287;cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG170324|UniProtKB=T1F2X4 T1F2X4 20203173 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG108161|UniProtKB=T1EEG1 T1EEG1 20194963 PTHR24302:SF15 CYTOCHROME P450 FAMILY 3 FATTY-ACID PEROXYGENASE oxygenase#PC00177;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG110038|UniProtKB=T1EEY5 T1EEY5 20195137 PTHR18934:SF213 ATP-DEPENDENT RNA HELICASE 3'-5' RNA HELICASE YTHDC2 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640 cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG156445|UniProtKB=T1ELW8 T1ELW8 20197568 PTHR43377:SF2 BILIVERDIN REDUCTASE A BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00560)-RELATED dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG171321|UniProtKB=T1F440 T1F440 20203589 PTHR24104:SF57 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED BEE-MILK PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG105252|UniProtKB=T1EDS3 T1EDS3 20194725 PTHR12433:SF11 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 25 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 25 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG166413|UniProtKB=T1EY39 T1EY39 20201489 PTHR13144:SF0 TEX261 PROTEIN PROTEIN TEX261 cargo receptor activity#GO:0038024 localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987 bounding membrane of organelle#GO:0098588;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;Golgi membrane#GO:0000139;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG159915|UniProtKB=T1EPJ8 T1EPJ8 20198498 PTHR24249:SF406 HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG151008|UniProtKB=T1EKI1 T1EKI1 20197081 PTHR43968:SF6 FAMILY NOT NAMED GLUTATHIONE S-TRANSFERASE OMEGA cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG194458|UniProtKB=T1FW27 T1FW27 20213023 PTHR16008:SF6 F-BOX ONLY PROTEIN 4 SI:DKEY-12E7.1 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234 HELRO|EnsemblGenome=HelroG144825|UniProtKB=T1EJG7 T1EJG7 20196717 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG88668|UniProtKB=T1G752 T1G752 20216899 PTHR46202:SF1 DNA EXCISION REPAIR PROTEIN ERCC-8 DNA EXCISION REPAIR PROTEIN ERCC-8 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;macromolecule modification#GO:0043412;protein catabolic process#GO:0030163;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;nucleobase-containing compound metabolic process#GO:0006139;modification-dependent macromolecule catabolic process#GO:0043632;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;nucleotide-excision repair#GO:0006289;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;cellular response to stimulus#GO:0051716;protein ubiquitination#GO:0016567;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation or removal#GO:0070647;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259 ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234;nucleotide-excision repair complex#GO:0000109;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;Cul4-RING E3 ubiquitin ligase complex#GO:0080008;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG82595|UniProtKB=T1G4U2 T1G4U2 20216090 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG179098|UniProtKB=T1FE57 T1FE57 20207106 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG73742|UniProtKB=T1G1H9 T1G1H9 20214927 PTHR46131:SF1 SD08549P SD08549P purine nucleotide transmembrane transporter activity#GO:0015216;nucleobase-containing compound transmembrane transporter activity#GO:0015932;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG163158|UniProtKB=T1ETQ9 T1ETQ9 20199959 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG183049|UniProtKB=T1FJ39 T1FJ39 20208838 PTHR10166:SF43 VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED VWA N-TERMINAL DOMAIN-CONTAINING PROTEIN calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated calcium channel activity#GO:0005245;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 voltage-gated calcium channel complex#GO:0005891;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;calcium channel complex#GO:0034704;membrane#GO:0016020;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG72657|UniProtKB=T1G133 T1G133 20214781 PTHR11348:SF17 CONNECTIVE TISSUE GROWTH FACTOR-RELATED CCN carbohydrate derivative binding#GO:0097367;integrin binding#GO:0005178;binding#GO:0005488;heparin binding#GO:0008201;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;glycosaminoglycan binding#GO:0005539;signaling receptor binding#GO:0005102 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;positive regulation of cell differentiation#GO:0045597;cell communication#GO:0007154;cell adhesion#GO:0007155;cellular process#GO:0009987;regulation of cell differentiation#GO:0045595;positive regulation of developmental process#GO:0051094;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;biological regulation#GO:0065007;signaling#GO:0023052;positive regulation of biological process#GO:0048518 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;extracellular space#GO:0005615;extracellular region#GO:0005576 growth factor#PC00112 HELRO|EnsemblGenome=HelroG184972|UniProtKB=T1FM79 T1FM79 20209928 PTHR23222:SF0 PROHIBITIN PROHIBITIN 1 HELRO|EnsemblGenome=HelroG178527|UniProtKB=T1FDB3 T1FDB3 20206812 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG68918|UniProtKB=T1FZL4 T1FZL4 20214262 PTHR24083:SF104 NUCLEAR HORMONE RECEPTOR TRANSCRIPTION FACTOR HNF-4 HOMOLOG cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;signaling receptor activity#GO:0038023;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG110947|UniProtKB=T1EF65 T1EF65 20195217 PTHR11727:SF17 DIMETHYLADENOSINE TRANSFERASE DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL catalytic activity, acting on RNA#GO:0140098;N-methyltransferase activity#GO:0008170;transcription regulator activity#GO:0140110;transferase activity#GO:0016740;rRNA (adenine) methyltransferase activity#GO:0016433;catalytic activity#GO:0003824;catalytic activity, acting on a rRNA#GO:0140102;catalytic activity, acting on a nucleic acid#GO:0140640;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;rRNA methyltransferase activity#GO:0008649;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;RNA methyltransferase activity#GO:0008173 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;cellular component biogenesis#GO:0044085;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA modification#GO:0009451;rRNA modification#GO:0000154;mitochondrial gene expression#GO:0140053;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;mitochondrial transcription#GO:0006390;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;ribosome biogenesis#GO:0042254;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;mitochondrial RNA metabolic process#GO:0000959;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;cellular component organization or biogenesis#GO:0071840;rRNA methylation#GO:0031167;nucleic acid metabolic process#GO:0090304;macromolecule methylation#GO:0043414;nucleobase-containing compound biosynthetic process#GO:0034654;methylation#GO:0032259;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;aromatic compound biosynthetic process#GO:0019438;RNA methylation#GO:0001510 membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG189266|UniProtKB=T1FQW1 T1FQW1 20211208 PTHR14159:SF0 ATAXIN-3-RELATED ATAXIN-3-RELATED cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG193603|UniProtKB=T1FV61 T1FV61 20212707 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG164179|UniProtKB=T1EV18 T1EV18 20200418 PTHR46880:SF5 RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194117|UniProtKB=T1FVP9 T1FVP9 20212895 PTHR13900:SF0 TRANSCRIPTION INITIATION FACTOR TFIID TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1 protein binding#GO:0005515;transcription factor binding#GO:0008134;binding#GO:0005488;TBP-class protein binding#GO:0017025 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;RNA metabolic process#GO:0016070;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;RNA polymerase II preinitiation complex assembly#GO:0051123;transcription initiation at RNA polymerase II promoter#GO:0006367;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;DNA-directed RNA polymerase complex#GO:0000428;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nucleoplasm#GO:0005654;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;transcription factor TFIID complex#GO:0005669;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;transcription regulator complex#GO:0005667;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG91686|UniProtKB=T1G880 T1G880 20217277 PTHR11627:SF80 FRUCTOSE-BISPHOSPHATE ALDOLASE FRUCTOSE-BISPHOSPHATE ALDOLASE-RELATED aldolase#PC00044;lyase#PC00144 Glycolysis#P00024>Aldolase#P00679;Fructose galactose metabolism#P02744>Fructose bisphosphate aldolase#P02959 HELRO|EnsemblGenome=HelroG169894|UniProtKB=T1F2F0 T1F2F0 20203000 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG177723|UniProtKB=T1FC48 T1FC48 20206397 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG180721|UniProtKB=T1FG73 T1FG73 20207822 PTHR45625:SF2 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3 peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein peptidyl-prolyl isomerization#GO:0000413;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ribonucleoprotein complex#GO:1990904;catalytic step 2 spliceosome#GO:0071013;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG195098|UniProtKB=T1FWQ9 T1FWQ9 20213254 PTHR12544:SF29 GLUTAMINASE GLUTAMINASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824 dicarboxylic acid metabolic process#GO:0043648;proteinogenic amino acid biosynthetic process#GO:0170038;organonitrogen compound catabolic process#GO:1901565;biosynthetic process#GO:0009058;carboxylic acid biosynthetic process#GO:0046394;amino acid catabolic process#GO:0009063;nitrogen compound metabolic process#GO:0006807;glutamate metabolic process#GO:0006536;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;L-amino acid metabolic process#GO:0170033;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248;organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;alpha-amino acid biosynthetic process#GO:1901607;L-amino acid biosynthetic process#GO:0170034;small molecule biosynthetic process#GO:0044283;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG189216|UniProtKB=T1FQT1 T1FQT1 20211178 PTHR42985:SF40 SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER LD47995P-RELATED symporter activity#GO:0015293;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;monoatomic cation transport#GO:0006812;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG177697|UniProtKB=T1FC34 T1FC34 20206383 PTHR12837:SF15 POLY ADP-RIBOSE GLYCOHYDROLASE POLY(ADP-RIBOSE) GLYCOHYDROLASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 ribonucleoside triphosphate metabolic process#GO:0009199;cellular aromatic compound metabolic process#GO:0006725;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative metabolic process#GO:1901135;regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA metabolic process#GO:0051052;regulation of DNA repair#GO:0006282;nucleotide-sugar metabolic process#GO:0009225;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;regulation of cellular response to stress#GO:0080135;organic cyclic compound metabolic process#GO:1901360;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule metabolic process#GO:0043170;purine ribonucleoside triphosphate metabolic process#GO:0009205;regulation of response to stress#GO:0080134;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;regulation of response to stimulus#GO:0048583;regulation of primary metabolic process#GO:0080090;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;purine nucleoside triphosphate metabolic process#GO:0009144;nucleotide metabolic process#GO:0009117;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosidase#PC00110;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG111131|UniProtKB=T1EF85 T1EF85 20195237 PTHR46116:SF15 (E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME (E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG194396|UniProtKB=T1FW05 T1FW05 20213001 PTHR13083:SF3 WD REPEAT-CONTAINING PROTEIN 91 WD REPEAT-CONTAINING PROTEIN 91 enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 localization#GO:0051179;endosomal transport#GO:0016197;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;cellular process#GO:0009987;early endosome to late endosome transport#GO:0045022 bounding membrane of organelle#GO:0098588;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;early endosome#GO:0005769;late endosome membrane#GO:0031902;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endosome membrane#GO:0010008;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;early endosome membrane#GO:0031901;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770 HELRO|EnsemblGenome=HelroG189846|UniProtKB=T1FRF1 T1FRF1 20211398 PTHR31691:SF1 ROTATIN ROTATIN HELRO|EnsemblGenome=HelroG165075|UniProtKB=T1EW94 T1EW94 20200844 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG116445|UniProtKB=T1EGF1 T1EGF1 20195653 PTHR21321:SF4 PNAS-3 RELATED EXOSOME COMPLEX COMPONENT RRP4 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159 negative regulation of gene expression#GO:0010629;cellular component biogenesis#GO:0044085;regulation of catabolic process#GO:0009894;heterocycle catabolic process#GO:0046700;regulation of nitrogen compound metabolic process#GO:0051171;rRNA processing#GO:0006364;positive regulation of cellular metabolic process#GO:0031325;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA destabilization#GO:0050779;regulation of biological process#GO:0050789;ncRNA metabolic process#GO:0034660;mRNA metabolic process#GO:0016071;regulation of biological quality#GO:0065008;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;snRNA 3'-end processing#GO:0034472;ribosome biogenesis#GO:0042254;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;cellular component organization or biogenesis#GO:0071840;positive regulation of mRNA catabolic process#GO:0061014;regulation of cellular process#GO:0050794;rRNA metabolic process#GO:0016072;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of catabolic process#GO:0009896;mRNA destabilization#GO:0061157;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323;positive regulation of nitrogen compound metabolic process#GO:0051173;cellular aromatic compound metabolic process#GO:0006725;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of mRNA stability#GO:0043488;regulation of mRNA catabolic process#GO:0061013;RNA metabolic process#GO:0016070;positive regulation of cellular catabolic process#GO:0031331;RNA processing#GO:0006396;biosynthetic process#GO:0009058;cellular nitrogen compound catabolic process#GO:0044270;positive regulation of metabolic process#GO:0009893;organic cyclic compound metabolic process#GO:1901360;mRNA catabolic process#GO:0006402;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;snRNA processing#GO:0016180;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;maturation of 5.8S rRNA#GO:0000460;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;positive regulation of mRNA metabolic process#GO:1903313;heterocycle metabolic process#GO:0046483;snRNA metabolic process#GO:0016073;macromolecule biosynthetic process#GO:0009059;negative regulation of biosynthetic process#GO:0009890;RNA 3'-end processing#GO:0031123;cellular biosynthetic process#GO:0044249;nuclear-transcribed mRNA catabolic process#GO:0000956;organic substance biosynthetic process#GO:1901576;regulation of cellular catabolic process#GO:0031329;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;regulation of cellular biosynthetic process#GO:0031326;aromatic compound catabolic process#GO:0019439;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;ribonucleoprotein complex biogenesis#GO:0022613;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;positive regulation of RNA metabolic process#GO:0051254 cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;exosome (RNase complex)#GO:0000178;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG191512|UniProtKB=T1FT21 T1FT21 20211968 PTHR45691:SF6 PROTEIN DIAPHANOUS PROTEIN DIAPHANOUS cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-containing complex assembly#GO:0065003;actin polymerization or depolymerization#GO:0008154;actin filament polymerization#GO:0030041;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;protein polymerization#GO:0051258;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036 supramolecular complex#GO:0099080;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;supramolecular fiber#GO:0099512;supramolecular polymer#GO:0099081;actin filament#GO:0005884;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG180355|UniProtKB=T1FFT3 T1FFT3 20207682 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159625|UniProtKB=T1EP93 T1EP93 20198393 PTHR15111:SF0 RNA POLYMERASE II SUBUNIT 5-MEDIATING PROTEIN NNX3 UNCONVENTIONAL PREFOLDIN RPB5 INTERACTOR 1 molecular adaptor activity#GO:0060090;phosphatase regulator activity#GO:0019208;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;binding#GO:0005488;molecular function regulator activity#GO:0098772;chromatin binding#GO:0003682;protein-macromolecule adaptor activity#GO:0030674;protein-containing complex binding#GO:0044877;enzyme inhibitor activity#GO:0004857;phosphatase inhibitor activity#GO:0019212;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 negative regulation of hydrolase activity#GO:0051346;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of phosphate metabolic process#GO:0019220;negative regulation of RNA metabolic process#GO:0051253;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;regulation of transcription by RNA polymerase II#GO:0006357;regulation of dephosphorylation#GO:0035303;regulation of RNA biosynthetic process#GO:2001141;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;regulation of molecular function#GO:0065009;regulation of biosynthetic process#GO:0009889;regulation of hydrolase activity#GO:0051336;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;regulation of DNA-templated transcription#GO:0006355;negative regulation of phosphorus metabolic process#GO:0010563;regulation of phosphatase activity#GO:0010921;negative regulation of metabolic process#GO:0009892;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of phosphate metabolic process#GO:0045936;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of catalytic activity#GO:0043086;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;negative regulation of molecular function#GO:0044092;regulation of cellular metabolic process#GO:0031323 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG188708|UniProtKB=T1FQA2 T1FQA2 20210999 PTHR14493:SF50 UNKEMPT FAMILY MEMBER RING FINGER PROTEIN UNKEMPT HELRO|EnsemblGenome=HelroG182426|UniProtKB=T1FI64 T1FI64 20208513 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162315|UniProtKB=T1ESI1 T1ESI1 20199531 PTHR21844:SF2 AKT1 SUBSTRATE 1 PROTEIN PROLINE-RICH AKT1 SUBSTRATE 1 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;regulation of catalytic activity#GO:0050790;regulation of intracellular signal transduction#GO:1902531;negative regulation of TOR signaling#GO:0032007;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;negative regulation of protein phosphorylation#GO:0001933;negative regulation of protein modification process#GO:0031400;regulation of molecular function#GO:0065009;regulation of signal transduction#GO:0009966;negative regulation of protein kinase activity#GO:0006469;negative regulation of cellular process#GO:0048523;negative regulation of cell communication#GO:0010648;regulation of kinase activity#GO:0043549;regulation of protein kinase activity#GO:0045859;regulation of cell communication#GO:0010646;negative regulation of response to stimulus#GO:0048585;negative regulation of phosphorus metabolic process#GO:0010563;negative regulation of signaling#GO:0023057;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of TOR signaling#GO:0032006;regulation of response to stimulus#GO:0048583;regulation of primary metabolic process#GO:0080090;regulation of macromolecule metabolic process#GO:0060255;negative regulation of phosphorylation#GO:0042326;regulation of cellular process#GO:0050794;regulation of protein phosphorylation#GO:0001932;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of phosphate metabolic process#GO:0045936;negative regulation of signal transduction#GO:0009968;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;negative regulation of catalytic activity#GO:0043086;regulation of metabolic process#GO:0019222;negative regulation of molecular function#GO:0044092;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 CCKR signaling map#P06959>PRAS40#P07076 HELRO|EnsemblGenome=HelroG184876|UniProtKB=T1FM42 T1FM42 20209891 PTHR21021:SF16 GAF/PUTATIVE CYTOSKELETAL PROTEIN TIP41-LIKE PROTEIN oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;regulation of nitrogen compound metabolic process#GO:0051171;regulation of phosphatase activity#GO:0010921;regulation of dephosphorylation#GO:0035303;cell communication#GO:0007154;regulation of catalytic activity#GO:0050790;cellular process#GO:0009987;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of molecular function#GO:0065009;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336;intracellular signal transduction#GO:0035556;signaling#GO:0023052;regulation of metabolic process#GO:0019222;TOR signaling#GO:0031929;regulation of phosphoprotein phosphatase activity#GO:0043666;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG105761|UniProtKB=T1EDX3 T1EDX3 20194775 PTHR11157:SF12 FATTY ACID ACYL TRANSFERASE-RELATED ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 4 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;monocarboxylic acid biosynthetic process#GO:0072330;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;organic acid metabolic process#GO:0006082;membrane lipid biosynthetic process#GO:0046467;sphingolipid metabolic process#GO:0006665;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;fatty acid metabolic process#GO:0006631;membrane lipid metabolic process#GO:0006643;nitrogen compound metabolic process#GO:0006807;small molecule biosynthetic process#GO:0044283;cellular lipid metabolic process#GO:0044255;carboxylic acid metabolic process#GO:0019752;sphingolipid biosynthetic process#GO:0030148;fatty acid biosynthetic process#GO:0006633;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG164083|UniProtKB=T1EUW5 T1EUW5 20200365 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180801|UniProtKB=T1FGA8 T1FGA8 20207857 PTHR23107:SF34 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN HTH LA-TYPE RNA-BINDING DOMAIN-CONTAINING PROTEIN transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG110204|UniProtKB=T1EF04 T1EF04 20195156 PTHR33442:SF1 TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG185812|UniProtKB=T1FNB8 T1FNB8 20210315 PTHR11227:SF17 WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED AUTOPHAGY-RELATED 18A, ISOFORM E phosphatidylinositol-3-phosphate binding#GO:0032266;phosphatidylinositol bisphosphate binding#GO:1902936;small molecule binding#GO:0036094;binding#GO:0005488;lipid binding#GO:0008289;phosphatidylinositol binding#GO:0035091;anion binding#GO:0043168;ion binding#GO:0043167;phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981 cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;macroautophagy#GO:0016236;macromolecule localization#GO:0033036;macromolecule modification#GO:0043412;protein modification process#GO:0036211;autophagy of mitochondrion#GO:0000422;biosynthetic process#GO:0009058;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;cellular component disassembly#GO:0022411;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;mitochondrion organization#GO:0007005;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organelle disassembly#GO:1903008;lipoprotein biosynthetic process#GO:0042158;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular macromolecule localization#GO:0070727;organelle organization#GO:0006996;autophagosome assembly#GO:0000045;lipoprotein metabolic process#GO:0042157;autophagy#GO:0006914 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;phagophore assembly site#GO:0000407;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;extrinsic component of membrane#GO:0019898 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG62957|UniProtKB=T1FX84 T1FX84 20213432 PTHR24416:SF621 TYROSINE-PROTEIN KINASE RECEPTOR TYROSINE KINASE RECEPTOR CAD96CA signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG179618|UniProtKB=T1FEY0 T1FEY0 20207379 PTHR46218:SF4 LASP LIM AND SH3 DOMAIN PROTEIN LASP HELRO|EnsemblGenome=HelroG191359|UniProtKB=T1FSX2 T1FSX2 20211919 PTHR46116:SF15 (E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME (E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG189109|UniProtKB=T1FQN8 T1FQN8 20211135 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG194029|UniProtKB=T1FVL2 T1FVL2 20212858 PTHR10981:SF0 BATTENIN BATTENIN regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;regulation of biological quality#GO:0065008;intracellular monoatomic cation homeostasis#GO:0030003;biological regulation#GO:0065007;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;chemical homeostasis#GO:0048878;cellular homeostasis#GO:0019725;regulation of cellular pH#GO:0030641;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG163606|UniProtKB=T1EU98 T1EU98 20200148 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG173116|UniProtKB=T1F6E0 T1F6E0 20204389 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG163656|UniProtKB=T1EUB8 T1EUB8 20200168 PTHR23235:SF155 KRUEPPEL-LIKE TRANSCRIPTION FACTOR EARLY GROWTH RESPONSE 4-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG192309|UniProtKB=T1FTT4 T1FTT4 20212231 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG154955|UniProtKB=T1ELG6 T1ELG6 20197416 PTHR12056:SF2 DNA-DIRECTED RNA POLYMERASES I, II, AND III GEO11084P1 catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;RNA polymerase activity#GO:0097747;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;RNA polymerase III activity#GO:0001056;RNA polymerase II activity#GO:0001055;RNA polymerase I activity#GO:0001054 membrane-enclosed lumen#GO:0031974;RNA polymerase II, core complex#GO:0005665;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase II, holoenzyme#GO:0016591;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;RNA polymerase III complex#GO:0005666;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;RNA polymerase I complex#GO:0005736;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG190664|UniProtKB=T1FS69 T1FS69 20211666 PTHR46421:SF1 PROGRAMMED CELL DEATH PROTEIN 2-LIKE PROGRAMMED CELL DEATH PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG186162|UniProtKB=T1FNR1 T1FNR1 20210458 PTHR11353:SF26 CHAPERONIN T-COMPLEX PROTEIN 1 SUBUNIT DELTA protein binding#GO:0005515;unfolded protein binding#GO:0051082;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 chaperonin#PC00073 HELRO|EnsemblGenome=HelroG150039|UniProtKB=T1EKE0 T1EKE0 20197040 PTHR23280:SF25 4.1 G PROTEIN MOESIN_EZRIN_RADIXIN HOMOLOG 1 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;actomyosin structure organization#GO:0031032;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG192854|UniProtKB=T1FUD1 T1FUD1 20212427 PTHR15507:SF17 ZINC FINGER PROTEIN RLF C2H2-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG172456|UniProtKB=T1F5C5 T1F5C5 20204024 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG76722|UniProtKB=T1G2N5 T1G2N5 20215333 PTHR24068:SF129 UBIQUITIN-CONJUGATING ENZYME E2 NEDD8-CONJUGATING ENZYME UBE2F ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein neddylation#GO:0045116;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG186734|UniProtKB=T1FP27 T1FP27 20210574 PTHR12176:SF78 SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN EEF1A LYSINE AND N-TERMINAL METHYLTRANSFERASE methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG185427|UniProtKB=T1FMT2 T1FMT2 20210131 PTHR10516:SF443 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FK506-BINDING PROTEIN 59-RELATED chaperone#PC00072 TGF-beta signaling pathway#P00052>FKBP12#P01288 HELRO|EnsemblGenome=HelroG194885|UniProtKB=T1FWJ2 T1FWJ2 20213187 PTHR46273:SF4 MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED AT19640P signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG186075|UniProtKB=T1FNM8 T1FNM8 20210425 PTHR14978:SF0 BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN BETA-CATENIN-LIKE PROTEIN 1 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG158828|UniProtKB=T1ENB2 T1ENB2 20198062 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168144|UniProtKB=T1F079 T1F079 20202229 PTHR11474:SF126 TYROSINASE FAMILY MEMBER TYROSINASE-LIKE PROTEIN TYR-1-RELATED oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG185710|UniProtKB=T1FN65 T1FN65 20210263 PTHR10535:SF0 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1 catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;RNA polymerase activity#GO:0097747;transferase activity, transferring phosphorus-containing groups#GO:0016772;RNA polymerase III activity#GO:0001056;RNA polymerase II activity#GO:0001055;RNA polymerase I activity#GO:0001054 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;DNA-templated transcription#GO:0006351;RNA metabolic process#GO:0016070;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;transcription by RNA polymerase I#GO:0006360;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;rRNA transcription#GO:0009303;nucleolar large rRNA transcription by RNA polymerase I#GO:0042790;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;transcription elongation by RNA polymerase I#GO:0006362;heterocycle metabolic process#GO:0046483;transcription by RNA polymerase III#GO:0006383;DNA-templated transcription elongation#GO:0006354;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;ncRNA transcription#GO:0098781;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366 membrane-enclosed lumen#GO:0031974;RNA polymerase II, core complex#GO:0005665;organelle lumen#GO:0043233;nucleus#GO:0005634;DNA-directed RNA polymerase complex#GO:0000428;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nucleoplasm#GO:0005654;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;RNA polymerase II, holoenzyme#GO:0016591;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;RNA polymerase III complex#GO:0005666;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;RNA polymerase I complex#GO:0005736;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388;General transcription regulation#P00023>RNA Polymerase II#P00660 HELRO|EnsemblGenome=HelroG159594|UniProtKB=T1EP79 T1EP79 20198379 PTHR13217:SF6 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052;Rho protein signal transduction#GO:0007266 HELRO|EnsemblGenome=HelroG68049|UniProtKB=T1FZ96 T1FZ96 20214144 PTHR24092:SF190 PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE PHOSPHOLIPID-TRANSPORTING ATPASE ATPase-coupled intramembrane lipid transporter activity#GO:0140326;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;lipid transporter activity#GO:0005319 organophosphate ester transport#GO:0015748;Golgi organization#GO:0007030;macromolecule localization#GO:0033036;membrane organization#GO:0061024;transport#GO:0006810;endomembrane system organization#GO:0010256;cellular component organization#GO:0016043;regulation of membrane lipid distribution#GO:0097035;phospholipid transport#GO:0015914;cellular process#GO:0009987;lipid transport#GO:0006869;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;organelle organization#GO:0006996;biological regulation#GO:0065007;lipid translocation#GO:0034204;lipid localization#GO:0010876;phospholipid translocation#GO:0045332 cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi apparatus subcompartment#GO:0098791;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG164986|UniProtKB=T1EW26 T1EW26 20200776 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG85777|UniProtKB=T1G627 T1G627 20216524 PTHR21490:SF0 ENKURIN-RELATED ENKURIN protein binding#GO:0005515;calmodulin binding#GO:0005516;binding#GO:0005488 HELRO|EnsemblGenome=HelroG182846|UniProtKB=T1FIU8 T1FIU8 20208747 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG179568|UniProtKB=T1FEV9 T1FEV9 20207358 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG188546|UniProtKB=T1FQ39 T1FQ39 20210936 PTHR21532:SF0 PHOSPHODIESTERASE HL CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 36 axoneme#GO:0005930;ciliary base#GO:0097546;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;plasma membrane bounded cell projection cytoplasm#GO:0032838;ciliary plasm#GO:0097014;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cytoskeleton#GO:0005856;cilium#GO:0005929 phosphodiesterase#PC00185;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG147791|UniProtKB=T1EK28 T1EK28 20196928 PTHR19338:SF4 TRANSLOCASE OF INNER MITOCHONDRIAL MEMBRANE 13 HOMOLOG MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT HELRO|EnsemblGenome=HelroG94341|UniProtKB=T1G903 T1G903 20217550 PTHR11353:SF23 CHAPERONIN T-COMPLEX PROTEIN 1 SUBUNIT BETA protein binding#GO:0005515;unfolded protein binding#GO:0051082;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;chaperonin-containing T-complex#GO:0005832;protein folding chaperone complex#GO:0101031;intracellular anatomical structure#GO:0005622 chaperonin#PC00073 HELRO|EnsemblGenome=HelroG166444|UniProtKB=T1EY52 T1EY52 20201502 PTHR23036:SF195 CYTOKINE RECEPTOR FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;protein binding#GO:0005515;cytokine receptor activity#GO:0004896;binding#GO:0005488;cytokine binding#GO:0019955;transmembrane signaling receptor activity#GO:0004888 response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;response to cytokine#GO:0034097;cellular response to chemical stimulus#GO:0070887;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to cytokine stimulus#GO:0071345;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;cytokine-mediated signaling pathway#GO:0019221;signaling#GO:0023052 receptor complex#GO:0043235;external side of plasma membrane#GO:0009897;cell surface#GO:0009986;protein-containing complex#GO:0032991;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;side of membrane#GO:0098552;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG189218|UniProtKB=T1FQT2 T1FQT2 20211179 PTHR23322:SF6 FAS-ASSOCIATED PROTEIN UBX DOMAIN-CONTAINING PROTEIN 7 protein binding#GO:0005515;ubiquitin-like protein binding#GO:0032182;binding#GO:0005488;ubiquitin binding#GO:0043130 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG177331|UniProtKB=T1FBI4 T1FBI4 20206183 PTHR45710:SF26 C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 180 RH26557P defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG186066|UniProtKB=T1FNM3 T1FNM3 20210420 PTHR12611:SF0 PUR-TRANSCRIPTIONAL ACTIVATOR PURINE-RICH BINDING PROTEIN-ALPHA, ISOFORM B sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG155617|UniProtKB=T1ELJ8 T1ELJ8 20197448 PTHR23138:SF141 RAN BINDING PROTEIN NUCLEAR PORE COMPLEX PROTEIN NUP50 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG164856|UniProtKB=T1EVW3 T1EVW3 20200713 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG82476|UniProtKB=T1G4S7 T1G4S7 20216075 PTHR12630:SF1 N-LINKED OLIGOSACCHARIDE PROCESSING GLUCOSIDASE 2 SUBUNIT BETA carbohydrate derivative metabolic process#GO:1901135;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;endoplasmic reticulum protein-containing complex#GO:0140534;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG166269|UniProtKB=T1EXY7 T1EXY7 20201437 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG190256|UniProtKB=T1FRT6 T1FRT6 20211533 PTHR11815:SF10 SUCCINYL-COA SYNTHETASE BETA CHAIN SUCCINATE--COA LIGASE [GDP-FORMING] SUBUNIT BETA, MITOCHONDRIAL ligase activity#GO:0016874;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;sulfur compound metabolic process#GO:0006790;nucleobase-containing compound metabolic process#GO:0006139;energy derivation by oxidation of organic compounds#GO:0015980;phosphorus metabolic process#GO:0006793;tricarboxylic acid cycle#GO:0006099;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;amide metabolic process#GO:0043603;purine nucleotide metabolic process#GO:0006163;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;heterocycle metabolic process#GO:0046483;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;acyl-CoA metabolic process#GO:0006637;generation of precursor metabolites and energy#GO:0006091;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;ribonucleotide metabolic process#GO:0009259;primary metabolic process#GO:0044238;purine ribonucleotide metabolic process#GO:0009150;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG164189|UniProtKB=T1EV28 T1EV28 20200428 PTHR19860:SF42 DDB1- AND CUL4-ASSOCIATED FACTOR 12-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234;Cul4-RING E3 ubiquitin ligase complex#GO:0080008 HELRO|EnsemblGenome=HelroG188344|UniProtKB=T1FPW7 T1FPW7 20210864 PTHR10334:SF590 CYSTEINE-RICH SECRETORY PROTEIN-RELATED SCP DOMAIN-CONTAINING PROTEIN extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG184089|UniProtKB=T1FKK2 T1FKK2 20209351 PTHR47160:SF10 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77609|UniProtKB=T1G306 T1G306 20215454 PTHR11920:SF501 GUANYLYL CYCLASE GUANYLATE CYCLASE 32E adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG185029|UniProtKB=T1FMB0 T1FMB0 20209959 PTHR46228:SF2 KELCH DOMAIN-CONTAINING PROTEIN KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_4G14350) HELRO|EnsemblGenome=HelroG149645|UniProtKB=T1EKD1 T1EKD1 20197031 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG164740|UniProtKB=T1EVR6 T1EVR6 20200666 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG181941|UniProtKB=T1FHH4 T1FHH4 20208273 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG158805|UniProtKB=T1ENA2 T1ENA2 20198052 PTHR36191:SF1 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178934|UniProtKB=T1FDX3 T1FDX3 20207022 PTHR24260:SF136 FAMILY NOT NAMED GH08193P-RELATED HELRO|EnsemblGenome=HelroG162412|UniProtKB=T1ESM2 T1ESM2 20199572 PTHR12308:SF73 ANOCTAMIN ANOCTAMIN inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216 localization#GO:0051179;inorganic anion transmembrane transport#GO:0098661;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;transport#GO:0006810;chloride transport#GO:0006821;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG159772|UniProtKB=T1EPE0 T1EPE0 20198440 PTHR24637:SF388 COLLAGEN NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177242|UniProtKB=T1FBE2 T1FBE2 20206141 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG65834|UniProtKB=T1FYD2 T1FYD2 20213830 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG191722|UniProtKB=T1FT83 T1FT83 20212030 PTHR22883:SF23 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC6 palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular localization#GO:0051641;macromolecule localization#GO:0033036;macromolecule modification#GO:0043412;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;protein palmitoylation#GO:0018345;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;localization within membrane#GO:0051668;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein localization to membrane#GO:0072657;organonitrogen compound biosynthetic process#GO:1901566;protein targeting#GO:0006605;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;protein acylation#GO:0043543;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipoprotein biosynthetic process#GO:0042158;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;lipoprotein metabolic process#GO:0042157 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191868|UniProtKB=T1FTD3 T1FTD3 20212080 PTHR46007:SF8 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 C2H2-TYPE DOMAIN-CONTAINING PROTEIN molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;protein binding#GO:0005515;transcription factor binding#GO:0008134 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG185096|UniProtKB=T1FME2 T1FME2 20209991 PTHR47981:SF20 RAB FAMILY RAS-RELATED PROTEIN RAB-7A small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG175067|UniProtKB=T1F8S9 T1F8S9 20205228 PTHR31196:SF2 RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED HELRO|EnsemblGenome=HelroG109845|UniProtKB=T1EEW8 T1EEW8 20195120 PTHR24416:SF566 TYROSINE-PROTEIN KINASE RECEPTOR EPIDERMAL GROWTH FACTOR RECEPTOR signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 negative regulation of biological process#GO:0048519;signal transduction#GO:0007165;neurogenesis#GO:0022008;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;positive regulation of cell population proliferation#GO:0008284;regulation of catalytic activity#GO:0050790;nervous system development#GO:0007399;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;system development#GO:0048731;cell differentiation#GO:0030154;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;negative regulation of programmed cell death#GO:0043069;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;regulation of programmed cell death#GO:0043067;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;cellular developmental process#GO:0048869;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;regulation of apoptotic process#GO:0042981;regulation of cell population proliferation#GO:0042127;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;negative regulation of apoptotic process#GO:0043066;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;anatomical structure development#GO:0048856;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 basal plasma membrane#GO:0009925;receptor complex#GO:0043235;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;basal part of cell#GO:0045178;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 EGF receptor signaling pathway#P00018>EGFR#P00542;Cadherin signaling pathway#P00012>EGFR#P00466 HELRO|EnsemblGenome=HelroG163269|UniProtKB=T1ETU9 T1ETU9 20199999 PTHR10264:SF127 BAND 7 PROTEIN-RELATED PODOCIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG70801|UniProtKB=T1G0C4 T1G0C4 20214522 PTHR11347:SF219 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE, ISOFORM I hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric diester hydrolase activity#GO:0008081;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;cAMP-mediated signaling#GO:0019933;signaling#GO:0023052;cyclic-nucleotide-mediated signaling#GO:0019935 phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG98239|UniProtKB=T1G9L1 T1G9L1 20217757 PTHR11601:SF62 CYSTEINE DESULFURYLASE FAMILY MEMBER SELENOCYSTEINE LYASE lyase#PC00144 HELRO|EnsemblGenome=HelroG63904|UniProtKB=T1FXM2 T1FXM2 20213570 PTHR11267:SF198 T-BOX PROTEIN-RELATED T-BOX TRANSCRIPTION FACTOR TBX6L sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cell fate commitment#GO:0045165;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;cell fate specification#GO:0001708;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HELRO|EnsemblGenome=HelroG167292|UniProtKB=T1EZ81 T1EZ81 20201881 PTHR48225:SF7 HORMA DOMAIN-CONTAINING PROTEIN 1 MEIOSIS-SPECIFIC PROTEIN HOP1 HELRO|EnsemblGenome=HelroG70975|UniProtKB=T1G0F2 T1G0F2 20214550 PTHR12755:SF6 CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;tRNA processing#GO:0008033;RNA processing#GO:0006396;mRNA polyadenylation#GO:0006378;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;mRNA 3'-end processing#GO:0031124;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;tRNA splicing, via endonucleolytic cleavage and ligation#GO:0006388;mRNA processing#GO:0006397;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG193873|UniProtKB=T1FVF7 T1FVF7 20212803 PTHR42757:SF32 IGLON FAMILY OF IMMUNOGLOBULIN SUPERFAMILY-RELATED PROTEIN AMALGAM defense/immunity protein#PC00090;immunoglobulin#PC00123 HELRO|EnsemblGenome=HelroG190368|UniProtKB=T1FRX7 T1FRX7 20211574 PTHR23510:SF16 INNER MEMBRANE TRANSPORT PROTEIN YAJR MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG86641|UniProtKB=T1G6E9 T1G6E9 20216646 PTHR23257:SF954 SERINE-THREONINE PROTEIN KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;Ras protein signal transduction#GO:0007265;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG181430|UniProtKB=T1FH02 T1FH02 20208101 PTHR20338:SF8 NUCLEAR RESPIRATORY FACTOR 1 NUCLEAR RESPIRATORY FACTOR 1 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG184105|UniProtKB=T1FKL1 T1FKL1 20209360 PTHR10656:SF42 CELL FATE DETERMINING PROTEIN MAB21-RELATED CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED transferase#PC00220;nucleotidyltransferase#PC00174;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG78004|UniProtKB=T1G365 T1G365 20215513 PTHR10362:SF7 HISTIDINE AMMONIA-LYASE HISTIDINE AMMONIA-LYASE lyase activity#GO:0016829;catalytic activity#GO:0003824 lyase#PC00144 HELRO|EnsemblGenome=HelroG175278|UniProtKB=T1F935 T1F935 20205334 PTHR28607:SF4 EXPRESSED PROTEIN TRANSMEMBRANE PROTEIN HELRO|EnsemblGenome=HelroG114574|UniProtKB=T1EG31 T1EG31 20195533 PTHR43731:SF14 RHOMBOID PROTEASE PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG184715|UniProtKB=T1FLU5 T1FLU5 20209794 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG90113|UniProtKB=T1G7L1 T1G7L1 20217058 PTHR23122:SF72 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK GUANYLATE KINASE-LIKE DOMAIN-CONTAINING PROTEIN cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;cell-cell junction#GO:0005911;anchoring junction#GO:0070161;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG88724|UniProtKB=T1G758 T1G758 20216905 PTHR46289:SF17 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162396|UniProtKB=T1ESL7 T1ESL7 20199567 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN SI:DKEY-17M8.2 HELRO|EnsemblGenome=HelroG160945|UniProtKB=T1EQW4 T1EQW4 20198964 PTHR12752:SF9 PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN KRAMER, ISOFORM I HELRO|EnsemblGenome=HelroG83561|UniProtKB=T1G572 T1G572 20216220 PTHR10358:SF6 ENDOSULFINE ENDOSULFINE, ISOFORM A phosphatase regulator activity#GO:0019208;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888;enzyme inhibitor activity#GO:0004857;phosphatase inhibitor activity#GO:0019212;molecular function inhibitor activity#GO:0140678;protein phosphatase inhibitor activity#GO:0004864;enzyme regulator activity#GO:0030234 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of phosphorus metabolic process#GO:0010563;regulation of dephosphorylation#GO:0035303;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of phosphorus metabolic process#GO:0051174;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;negative regulation of protein modification process#GO:0031400;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of phosphate metabolic process#GO:0045936;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG160789|UniProtKB=T1EQQ3 T1EQQ3 20198903 PTHR12400:SF26 INOSITOL POLYPHOSPHATE KINASE KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;phosphotransferase activity, phosphate group as acceptor#GO:0016776 organic hydroxy compound metabolic process#GO:1901615;lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycerolipid biosynthetic process#GO:0045017;alcohol biosynthetic process#GO:0046165;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic hydroxy compound biosynthetic process#GO:1901617;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;alcohol metabolic process#GO:0006066;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;small molecule biosynthetic process#GO:0044283;cellular lipid metabolic process#GO:0044255;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 kinase#PC00137 HELRO|EnsemblGenome=HelroG172853|UniProtKB=T1F605 T1F605 20204254 PTHR20956:SF12 HEH2P FLYWCH-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG141773|UniProtKB=T1EJ41 T1EJ41 20196591 PTHR24229:SF103 NEUROPEPTIDES RECEPTOR ALLATOSTATIN A RECEPTOR 1, ISOFORM B neuropeptide binding#GO:0042923;signaling receptor activity#GO:0038023;binding#GO:0005488;peptide binding#GO:0042277;amide binding#GO:0033218;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;neuropeptide signaling pathway#GO:0007218;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;neuron projection#GO:0043005;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG158518|UniProtKB=T1EMW5 T1EMW5 20197915 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG63123|UniProtKB=T1FXB3 T1FXB3 20213461 PTHR12756:SF9 CYTOSOLIC CARBOXYPEPTIDASE CYTOSOLIC CARBOXYPEPTIDASE 6 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG157216|UniProtKB=T1EM84 T1EM84 20197684 PTHR22883:SF43 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE APP palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular localization#GO:0051641;macromolecule localization#GO:0033036;macromolecule modification#GO:0043412;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;protein palmitoylation#GO:0018345;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;localization within membrane#GO:0051668;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein localization to membrane#GO:0072657;organonitrogen compound biosynthetic process#GO:1901566;protein targeting#GO:0006605;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;protein acylation#GO:0043543;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipoprotein biosynthetic process#GO:0042158;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;lipoprotein metabolic process#GO:0042157 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG160229|UniProtKB=T1EQ01 T1EQ01 20198651 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG81599|UniProtKB=T1G4G2 T1G4G2 20215960 PTHR11824:SF5 VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT CA2+-CHANNEL-PROTEIN-BETA-SUBUNIT, ISOFORM L calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated calcium channel activity#GO:0005245;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;regulation of metal ion transport#GO:0010959;trans-synaptic signaling#GO:0099537;regulation of calcium ion transport#GO:0051924;regulation of localization#GO:0032879;regulation of monoatomic cation transmembrane transport#GO:1904062;cellular component organization#GO:0016043;cell communication#GO:0007154;cellular process#GO:0009987;neuromuscular junction development#GO:0007528;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;synapse organization#GO:0050808;regulation of transport#GO:0051049;chemical synaptic transmission#GO:0007268;anterograde trans-synaptic signaling#GO:0098916;regulation of molecular function#GO:0065009;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;biological regulation#GO:0065007;synaptic signaling#GO:0099536;regulation of monoatomic ion transmembrane transporter activity#GO:0032412;regulation of monoatomic ion transport#GO:0043269;regulation of transmembrane transporter activity#GO:0022898;regulation of transporter activity#GO:0032409;cell-cell signaling#GO:0007267;signaling#GO:0023052 voltage-gated calcium channel complex#GO:0005891;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;calcium channel complex#GO:0034704;membrane#GO:0016020;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227;voltage-gated ion channel#PC00241 Thyrotropin-releasing hormone receptor signaling pathway#P04394>Ca2+ channel#P04587 HELRO|EnsemblGenome=HelroG173156|UniProtKB=T1F6G8 T1F6G8 20204417 PTHR46289:SF17 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166089|UniProtKB=T1EXQ8 T1EXQ8 20201358 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176785|UniProtKB=T1FAW8 T1FAW8 20205967 PTHR39369:SF6 LIN-24 (TWENTY-FOUR) LIKE LIN-24 (TWENTY-FOUR) LIKE HELRO|EnsemblGenome=HelroG174808|UniProtKB=T1F8I1 T1F8I1 20205130 PTHR21588:SF21 COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 6 CHCH DOMAIN-CONTAINING PROTEIN cellular component organization or biogenesis#GO:0071840;membrane organization#GO:0061024;organelle organization#GO:0006996;cellular component organization#GO:0016043;mitochondrial membrane organization#GO:0007006;mitochondrion organization#GO:0007005;cellular process#GO:0009987;inner mitochondrial membrane organization#GO:0007007 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;mitochondrial protein-containing complex#GO:0098798 HELRO|EnsemblGenome=HelroG85927|UniProtKB=T1G646 T1G646 20216543 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN SI:DKEY-17M8.2 HELRO|EnsemblGenome=HelroG185005|UniProtKB=T1FM96 T1FM96 20209945 PTHR43178:SF5 DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL fatty acid binding#GO:0005504;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acetyltransferase activity#GO:0016407;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;carboxylic acid binding#GO:0031406;heterocyclic compound binding#GO:1901363;lipid binding#GO:0008289;anion binding#GO:0043168;ion binding#GO:0043167;organic acid binding#GO:0043177 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 transferase#PC00220;acetyltransferase#PC00038;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG74016|UniProtKB=T1G1L2 T1G1L2 20214960 PTHR43895:SF32 CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED SERINE_THREONINE-PROTEIN KINASE CHK1 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG85673|UniProtKB=T1G613 T1G613 20216510 PTHR12581:SF0 HIV-1 REV BINDING PROTEIN 2, 3 KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG membrane-enclosed lumen#GO:0031974;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG190477|UniProtKB=T1FS07 T1FS07 20211604 PTHR12444:SF8 PROTEIN EFR3 HOMOLOG CMP44E PROTEIN EFR3 HOMOLOG CMP44E protein localization to cell periphery#GO:1990778;localization#GO:0051179;protein localization to plasma membrane#GO:0072659;localization within membrane#GO:0051668;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;cellular process#GO:0009987;protein localization#GO:0008104 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG80596|UniProtKB=T1G425 T1G425 20215823 PTHR12308:SF84 ANOCTAMIN ANOCTAMIN inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216 localization#GO:0051179;inorganic anion transmembrane transport#GO:0098661;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;transport#GO:0006810;chloride transport#GO:0006821;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG194913|UniProtKB=T1FWK2 T1FWK2 20213197 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG76849|UniProtKB=T1G2Q1 T1G2Q1 20215349 PTHR11827:SF6 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS SOLUTE CARRIER FAMILY 12 MEMBER 8 inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium ion transmembrane transporter activity#GO:0015079;symporter activity#GO:0015293;chloride transmembrane transporter activity#GO:0015108;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 inorganic ion homeostasis#GO:0098771;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;inorganic anion transmembrane transport#GO:0098661;import across plasma membrane#GO:0098739;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;inorganic anion transport#GO:0015698;potassium ion transport#GO:0006813;regulation of anatomical structure size#GO:0090066;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;monoatomic anion transmembrane transport#GO:0098656;chloride transport#GO:0006821;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;cellular component organization#GO:0016043;cellular process#GO:0009987;chemical homeostasis#GO:0048878;regulation of cellular component size#GO:0032535;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;regulation of cell size#GO:0008361;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;potassium ion import across plasma membrane#GO:1990573 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG168921|UniProtKB=T1F148 T1F148 20202548 PTHR21522:SF32 PROTON CHANNEL OTOP OTOPETRIN-2 monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078;proton channel activity#GO:0015252;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;proton transmembrane transport#GO:1902600;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG161850|UniProtKB=T1ERY8 T1ERY8 20199338 PTHR21349:SF0 50S RIBOSOMAL PROTEIN L21 LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 ribosomal protein#PC00202;translational protein#PC00263 Methylcitrate cycle#P02754>Aconitase#P03028 HELRO|EnsemblGenome=HelroG172153|UniProtKB=T1F527 T1F527 20203926 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED BRCT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG68939|UniProtKB=T1FZM2 T1FZM2 20214270 PTHR45720:SF10 CHLORIDE CHANNEL PROTEIN 2 CHLORIDE CHANNEL PROTEIN 2 voltage-gated monoatomic ion channel activity#GO:0005244;inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267 localization#GO:0051179;chloride transport#GO:0006821;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;inorganic anion transport#GO:0015698;monoatomic anion transport#GO:0006820;transport#GO:0006810 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG64166|UniProtKB=T1FXQ7 T1FXQ7 20213605 PTHR19857:SF8 MITOCHONDRIAL DIVISION PROTEIN 1-RELATED ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN HELRO|EnsemblGenome=HelroG191144|UniProtKB=T1FSN2 T1FSN2 20211829 PTHR31804:SF2 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15 CUE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG191247|UniProtKB=T1FSS5 T1FSS5 20211872 PTHR24023:SF910 COLLAGEN ALPHA COLLECTIN-12 structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG190245|UniProtKB=T1FRT2 T1FRT2 20211529 PTHR16212:SF4 FOCADHESIN FAMILY MEMBER FOCADHESIN HELRO|EnsemblGenome=HelroG176491|UniProtKB=T1FAK7 T1FAK7 20205856 PTHR43788:SF8 DNA2/NAM7 HELICASE FAMILY MEMBER DNA-BINDING PROTEIN SMUBP-2 catalytic activity, acting on a nucleic acid#GO:0140640;ATP-dependent activity, acting on DNA#GO:0008094;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG156910|UniProtKB=T1EM30 T1EM30 20197630 PTHR10926:SF0 CELL CYCLE CONTROL PROTEIN 50 CDC50, ISOFORM A cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG86725|UniProtKB=T1G6G2 T1G6G2 20216659 PTHR46690:SF1 CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6 HOMOLOG CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6 HOMOLOG aerobic respiration#GO:0009060;cellular component assembly#GO:0022607;cellular respiration#GO:0045333;cellular component biogenesis#GO:0044085;generation of precursor metabolites and energy#GO:0006091;protein-containing complex assembly#GO:0065003;electron transport chain#GO:0022900;cellular metabolic process#GO:0044237;ATP synthesis coupled electron transport#GO:0042773;cellular component organization#GO:0016043;cellular process#GO:0009987;energy derivation by oxidation of organic compounds#GO:0015980;cellular component organization or biogenesis#GO:0071840;mitochondrial ATP synthesis coupled electron transport#GO:0042775;respiratory chain complex IV assembly#GO:0008535;protein-containing complex organization#GO:0043933;respiratory electron transport chain#GO:0022904;cytochrome complex assembly#GO:0017004;oxidative phosphorylation#GO:0006119;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG144452|UniProtKB=T1EJE9 T1EJE9 20196699 PTHR22883:SF452 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular localization#GO:0051641;macromolecule localization#GO:0033036;macromolecule modification#GO:0043412;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;protein palmitoylation#GO:0018345;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;localization within membrane#GO:0051668;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein localization to membrane#GO:0072657;organonitrogen compound biosynthetic process#GO:1901566;protein targeting#GO:0006605;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;protein acylation#GO:0043543;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipoprotein biosynthetic process#GO:0042158;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;lipoprotein metabolic process#GO:0042157 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG172218|UniProtKB=T1F554 T1F554 20203953 PTHR13491:SF0 ZCCHC10 PROTEIN ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10 HELRO|EnsemblGenome=HelroG164377|UniProtKB=T1EVC5 T1EVC5 20200525 PTHR12141:SF5 ARFAPTIN-RELATED ARFAPTIN lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488 cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;trans-Golgi network membrane#GO:0032588;organelle subcompartment#GO:0031984;Golgi apparatus subcompartment#GO:0098791;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG115387|UniProtKB=T1EG78 T1EG78 20195580 PTHR42758:SF2 PHOSPHATIDYLGLYCEROL PHOSPHOLIPASE C PHOSPHATIDYLGLYCEROL PHOSPHOLIPASE C hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric diester hydrolase activity#GO:0008081;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 lipid metabolic process#GO:0006629;cellular metabolic process#GO:0044237;glycerophospholipid metabolic process#GO:0006650;glycerolipid catabolic process#GO:0046503;glycerophospholipid catabolic process#GO:0046475;lipid catabolic process#GO:0016042;cellular process#GO:0009987;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;organophosphate catabolic process#GO:0046434;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;phospholipid catabolic process#GO:0009395;catabolic process#GO:0009056;organophosphate metabolic process#GO:0019637;organic substance catabolic process#GO:1901575;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248 phospholipase#PC00186 HELRO|EnsemblGenome=HelroG111764|UniProtKB=T1EFE2 T1EFE2 20195294 PTHR10730:SF53 PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER GLYCOSYLTRANSFERASE 25 FAMILY MEMBER protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG98030|UniProtKB=T1G9K1 T1G9K1 20217747 PTHR11267:SF190 T-BOX PROTEIN-RELATED T-BOX TRANSCRIPTION FACTOR TBX20 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cell fate commitment#GO:0045165;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;cell fate specification#GO:0001708;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HELRO|EnsemblGenome=HelroG78519|UniProtKB=T1G3C5 T1G3C5 20215573 PTHR24253:SF153 TRANSMEMBRANE PROTEASE SERINE SERINE PROTEASE HEPSIN serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG68693|UniProtKB=T1FZI4 T1FZI4 20214232 PTHR10656:SF70 CELL FATE DETERMINING PROTEIN MAB21-RELATED PROTEIN MAB-21-RELATED transferase#PC00220;nucleotidyltransferase#PC00174;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG178959|UniProtKB=T1FDY9 T1FDY9 20207038 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG186335|UniProtKB=T1FNY7 T1FNY7 20210534 PTHR18919:SF107 ACETYL-COA C-ACYLTRANSFERASE ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG171311|UniProtKB=T1F431 T1F431 20203580 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG162023|UniProtKB=T1ES55 T1ES55 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG193880|UniProtKB=T1FVF8 T1FVF8 20212804 PTHR12802:SF41 SWI/SNF COMPLEX-RELATED BRAHMA ASSOCIATED PROTEIN 155 KDA chromatin/chromatin-binding, or -regulatory protein#PC00077 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG160742|UniProtKB=T1EQN5 T1EQN5 20198885 PTHR24366:SF96 IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS LEUCINE RICH REPEAT CONTAINING 53 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG75443|UniProtKB=T1G252 T1G252 20215150 PTHR11183:SF100 GLYCOGENIN SUBFAMILY MEMBER GLYCOGENIN, ISOFORM E transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG69993|UniProtKB=T1G012 T1G012 20214410 PTHR21231:SF8 XPA-BINDING PROTEIN 1-RELATED GPN-LOOP GTPASE 1 hydrolase activity#GO:0016787;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 small GTPase#PC00208;G-protein#PC00020;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG78293|UniProtKB=T1G3A4 T1G3A4 20215552 PTHR47633:SF4 IMMUNOGLOBULIN MYOPALLADIN ISOFORM X1 HELRO|EnsemblGenome=HelroG91059|UniProtKB=T1G7Z2 T1G7Z2 20217189 PTHR12010:SF2 40S RIBOSOMAL PROTEIN S29 40S RIBOSOMAL PROTEIN S29 cation binding#GO:0043169;structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;binding#GO:0005488;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;ion binding#GO:0043167 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cytoplasmic translation#GO:0002181;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;cytosol#GO:0005829;small ribosomal subunit#GO:0015935;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG164831|UniProtKB=T1EVV1 T1EVV1 20200701 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG179415|UniProtKB=T1FEN8 T1FEN8 20207287 PTHR24637:SF428 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG88702|UniProtKB=T1G756 T1G756 20216903 PTHR23516:SF23 SAM (S-ADENOSYL METHIONINE) TRANSPORTER MOLYBDATE-ANION TRANSPORTER cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG178416|UniProtKB=T1FD51 T1FD51 20206750 PTHR24023:SF1105 COLLAGEN ALPHA FIBRILLAR COLLAGEN NC1 DOMAIN-CONTAINING PROTEIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG88302|UniProtKB=T1G713 T1G713 20216860 PTHR10974:SF1 FI08016P-RELATED FI08016P-RELATED extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 HELRO|EnsemblGenome=HelroG96341|UniProtKB=T1G9B5 T1G9B5 20217662 PTHR11851:SF149 METALLOPROTEASE GH01077P cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG173085|UniProtKB=T1F6B5 T1F6B5 20204364 PTHR19303:SF74 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG62415|UniProtKB=T1FX02 T1FX02 20213350 PTHR11571:SF224 GLUTATHIONE S-TRANSFERASE HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE glutathione transferase activity#GO:0004364;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824 sulfur compound metabolic process#GO:0006790;nitrogen compound metabolic process#GO:0006807;peptide metabolic process#GO:0006518;cellular modified amino acid metabolic process#GO:0006575;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular process#GO:0009987;glutathione metabolic process#GO:0006749;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG73217|UniProtKB=T1G1B9 T1G1B9 20214867 PTHR23415:SF4 CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7 60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7 HOMOLOG cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;ribosome biogenesis#GO:0042254;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;ribonucleoprotein complex biogenesis#GO:0022613 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;preribosome, large subunit precursor#GO:0030687;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG107158|UniProtKB=T1EE80 T1EE80 20194882 PTHR11453:SF127 ANION EXCHANGE PROTEIN SOLUTE CARRIER FAMILY 4 MEMBER 11 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;homeostatic process#GO:0042592;cellular process#GO:0009987;chemical homeostasis#GO:0048878;monoatomic ion homeostasis#GO:0050801 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG158761|UniProtKB=T1EN82 T1EN82 20198032 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169046|UniProtKB=T1F1B3 T1F1B3 20202613 PTHR46543:SF1 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;modification-dependent macromolecule catabolic process#GO:0043632;regulation of biological process#GO:0050789;ncRNA metabolic process#GO:0034660;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;mRNA catabolic process#GO:0006402;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;negative regulation of cellular process#GO:0048523;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;snRNA metabolic process#GO:0016073;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;nuclear-transcribed mRNA catabolic process#GO:0000956;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;rRNA metabolic process#GO:0016072;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;polyadenylation-dependent ncRNA catabolic process#GO:0043634;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG105492|UniProtKB=T1EDV6 T1EDV6 20194758 PTHR10984:SF25 ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3 cytoplasm#GO:0005737;COPII-coated ER to Golgi transport vesicle#GO:0030134;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;coated vesicle#GO:0030135;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG177980|UniProtKB=T1FCK3 T1FCK3 20206552 PTHR48092:SF26 KNIRPS-RELATED PROTEIN-RELATED NR LBD DOMAIN-CONTAINING PROTEIN cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;signaling receptor activity#GO:0038023;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG77067|UniProtKB=T1G2S9 T1G2S9 20215377 PTHR11003:SF335 POTASSIUM CHANNEL, SUBFAMILY K POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG182588|UniProtKB=T1FIF1 T1FIF1 20208600 PTHR22802:SF396 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG184965|UniProtKB=T1FM78 T1FM78 20209927 PTHR11085:SF10 NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED nucleotide binding#GO:0000166;histone modifying activity#GO:0140993;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;deacetylase activity#GO:0019213;histone deacetylase activity#GO:0004407;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168;catalytic activity, acting on a protein#GO:0140096 HELRO|EnsemblGenome=HelroG191101|UniProtKB=T1FSL2 T1FSL2 20211809 PTHR14963:SF7 RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED RHO GTPASE-ACTIVATING PROTEIN 19 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG181601|UniProtKB=T1FH57 T1FH57 20208156 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182016|UniProtKB=T1FHL5 T1FHL5 20208314 PTHR11893:SF36 INNEXIN INNEXIN-5 cell junction protein#PC00070;gap junction#PC00105 HELRO|EnsemblGenome=HelroG76151|UniProtKB=T1G2F7 T1G2F7 20215255 PTHR31302:SF0 TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN-RELATED TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN HELRO|EnsemblGenome=HelroG174918|UniProtKB=T1F8M1 T1F8M1 20205170 PTHR39075:SF1 FI19908P1 FI19908P1 HELRO|EnsemblGenome=HelroG190616|UniProtKB=T1FS51 T1FS51 20211648 PTHR10459:SF108 DNA LIGASE POLY [ADP-RIBOSE] POLYMERASE transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;pentosyltransferase activity#GO:0016763;catalytic activity#GO:0003824 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;double-strand break repair#GO:0006302;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;post-translational protein modification#GO:0043687;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;response to stress#GO:0006950;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;metabolic process#GO:0008152 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG112317|UniProtKB=T1EFI5 T1EFI5 20195337 PTHR11347:SF206 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE HIGH AFFINITY CAMP-SPECIFIC AND IBMX-INSENSITIVE 3',5'-CYCLIC PHOSPHODIESTERASE 8 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric diester hydrolase activity#GO:0008081;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 regulation of cell communication#GO:0010646;cellular response to stimulus#GO:0051716;regulation of MAPK cascade#GO:0043408;signal transduction#GO:0007165;positive regulation of signal transduction#GO:0009967;regulation of signaling#GO:0023051;cell communication#GO:0007154;cellular process#GO:0009987;regulation of intracellular signal transduction#GO:1902531;positive regulation of MAPK cascade#GO:0043410;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;positive regulation of response to stimulus#GO:0048584;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of ERK1 and ERK2 cascade#GO:0070372;regulation of signal transduction#GO:0009966;positive regulation of cell communication#GO:0010647;biological regulation#GO:0065007;positive regulation of intracellular signal transduction#GO:1902533;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;positive regulation of ERK1 and ERK2 cascade#GO:0070374;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;signaling#GO:0023052;cAMP-mediated signaling#GO:0019933;cyclic-nucleotide-mediated signaling#GO:0019935 phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG76855|UniProtKB=T1G2Q2 T1G2Q2 20215350 PTHR12705:SF0 ORIGIN RECOGNITION COMPLEX SUBUNIT 5 ORIGIN RECOGNITION COMPLEX SUBUNIT 5 sequence-specific double-stranded DNA binding#GO:1990837;DNA replication origin binding#GO:0003688;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;DNA-templated DNA replication#GO:0006261;DNA replication#GO:0006260;DNA replication initiation#GO:0006270;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 origin recognition complex#GO:0000808;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;nuclear origin of replication recognition complex#GO:0005664;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 DNA metabolism protein#PC00009;replication origin binding protein#PC00199 HELRO|EnsemblGenome=HelroG77867|UniProtKB=T1G350 T1G350 20215498 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;chloride transmembrane transporter activity#GO:0015108;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;inorganic anion transmembrane transport#GO:0098661;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic anion transport#GO:0006820;chloride transport#GO:0006821;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;inorganic anion transport#GO:0015698 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG116430|UniProtKB=T1EGF0 T1EGF0 20195652 PTHR22762:SF131 ALPHA-GLUCOSIDASE GLYCOSIDE HYDROLASE FAMILY 31 N-TERMINAL DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;glucosidase activity#GO:0015926;hydrolase activity, acting on glycosyl bonds#GO:0016798;alpha-glucosidase activity#GO:0090599;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 glucosidase#PC00108;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG166545|UniProtKB=T1EY82 T1EY82 20201532 PTHR10504:SF131 BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED BPI2 DOMAIN-CONTAINING PROTEIN defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG85448|UniProtKB=T1G5X2 T1G5X2 20216469 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG193914|UniProtKB=T1FVH0 T1FVH0 20212816 PTHR16777:SF2 PROTEIN ECT2 PROTEIN ECT2 cell division#GO:0051301;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;developmental process#GO:0032502;multicellular organism development#GO:0007275;activation of GTPase activity#GO:0090630;cell cycle process#GO:0022402;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;cellular process#GO:0009987;nervous system development#GO:0007399;mitotic cell cycle process#GO:1903047;positive regulation of hydrolase activity#GO:0051345;system development#GO:0048731;mitotic cytokinesis#GO:0000281;mitotic cell cycle#GO:0000278;regulation of molecular function#GO:0065009;anatomical structure development#GO:0048856;biological regulation#GO:0065007;cytoskeleton-dependent cytokinesis#GO:0061640;cell cycle#GO:0007049;multicellular organismal process#GO:0032501;regulation of hydrolase activity#GO:0051336;cytokinesis#GO:0000910 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cell cortex#GO:0005938;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG108615|UniProtKB=T1EEL0 T1EEL0 20195012 PTHR11473:SF24 AROMATIC AMINO ACID HYDROXYLASE PHENYLALANINE-4-HYDROXYLASE oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG185420|UniProtKB=T1FMS9 T1FMS9 20210128 PTHR24068:SF153 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 W ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG110599|UniProtKB=T1EF34 T1EF34 20195186 PTHR11875:SF7 TESTIS-SPECIFIC Y-ENCODED PROTEIN AT14585P-RELATED protein binding#GO:0005515;protein-containing complex binding#GO:0044877;histone binding#GO:0042393;binding#GO:0005488;chromatin binding#GO:0003682 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;nucleosome organization#GO:0034728;nucleosome assembly#GO:0006334;protein-containing complex organization#GO:0043933;protein-containing complex assembly#GO:0065003;chromatin organization#GO:0006325;cellular component organization#GO:0016043;protein-DNA complex assembly#GO:0065004;chromatin remodeling#GO:0006338;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG180413|UniProtKB=T1FFW6 T1FFW6 20207715 PTHR34921:SF1 MEIOTIC RECOMBINATION PROTEIN REC114 MEIOTIC RECOMBINATION PROTEIN REC114 HELRO|EnsemblGenome=HelroG185545|UniProtKB=T1FMY8 T1FMY8 20210187 PTHR11085:SF12 NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-6 nucleotide binding#GO:0000166;histone modifying activity#GO:0140993;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;protein-macromolecule adaptor activity#GO:0030674;deacetylase activity#GO:0019213;molecular adaptor activity#GO:0060090;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;histone deacetylase activity#GO:0004407;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;organic cyclic compound binding#GO:0097159;transcription corepressor activity#GO:0003714;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;catalytic activity, acting on a protein#GO:0140096 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG190614|UniProtKB=T1FS50 T1FS50 20211647 PTHR12191:SF37 SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER FOI secondary active transmembrane transporter activity#GO:0015291;inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;symporter activity#GO:0015293;active monoatomic ion transmembrane transporter activity#GO:0022853;organic anion transmembrane transporter activity#GO:0008514;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;import across plasma membrane#GO:0098739;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation transport#GO:0006812;transition metal ion transport#GO:0000041;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG108666|UniProtKB=T1EEL3 T1EEL3 20195015 PTHR24349:SF514 SERINE/THREONINE-PROTEIN KINASE MAP KINASE-ACTIVATED PROTEIN KINASE 2 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein serine/threonine kinase activity#GO:0004674;protein binding#GO:0005515;calmodulin binding#GO:0005516;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Ras Pathway#P04393>MAPKAP#P04564;PDGF signaling pathway#P00047>MAPKAPK2#P01157;VEGF signaling pathway#P00056>MAPKAPK2/3#P01415;Angiogenesis#P00005>MAPKAPK2/3#P00244 HELRO|EnsemblGenome=HelroG195049|UniProtKB=T1FWQ0 T1FWQ0 20213245 PTHR24243:SF233 G-PROTEIN COUPLED RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG168746|UniProtKB=T1F0X0 T1F0X0 20202470 PTHR15641:SF1 ELONGATOR COMPLEX PROTEIN 5 ELONGATOR COMPLEX PROTEIN 5 tRNA binding#GO:0000049;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 elongator holoenzyme complex#GO:0033588;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG156056|UniProtKB=T1ELR1 T1ELR1 20197511 PTHR24072:SF359 RHO FAMILY GTPASE RAS-RELATED PROTEIN RAC1-RELATED GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;enzyme binding#GO:0019899;ribonucleoside triphosphate phosphatase activity#GO:0017111;kinase binding#GO:0019900;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817;protein kinase binding#GO:0019901;anion binding#GO:0043168;ion binding#GO:0043167 establishment or maintenance of cell polarity#GO:0007163;regulation of anatomical structure morphogenesis#GO:0022603;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cytoskeleton organization#GO:0051493;regulation of cell shape#GO:0008360;regulation of biological quality#GO:0065008;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;organelle organization#GO:0006996;cortical cytoskeleton organization#GO:0030865;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;regulation of actin filament-based process#GO:0032970 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 small GTPase#PC00208 T cell activation#P00053>rac#P01324;Huntington disease#P00029>Rac#P00775;Cytoskeletal regulation by Rho GTPase#P00016>Rac#P00523;EGF receptor signaling pathway#P00018>Rac#P00564;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Cdc42#P00834;Ras Pathway#P04393>Rac#P04559;Axon guidance mediated by netrin#P00009>Rac#P00366;Integrin signalling pathway#P00034>Rac#P00927;Axon guidance mediated by Slit/Robo#P00008>Rac#P00354;FGF signaling pathway#P00021>Rac#P00645 HELRO|EnsemblGenome=HelroG100404|UniProtKB=T1ECZ5 T1ECZ5 20194447 PTHR11811:SF25 6-PHOSPHOGLUCONATE DEHYDROGENASE 6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;pyridine nucleotide metabolic process#GO:0019362;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;carbohydrate catabolic process#GO:0016052;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;carbohydrate metabolic process#GO:0005975;NADP metabolic process#GO:0006739;purine nucleotide metabolic process#GO:0006163;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;heterocycle metabolic process#GO:0046483;generation of precursor metabolites and energy#GO:0006091;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;nicotinamide nucleotide metabolic process#GO:0046496;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;glucose 6-phosphate metabolic process#GO:0051156;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;carboxylic acid metabolic process#GO:0019752;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092;oxidoreductase#PC00176 Pentose phosphate pathway#P02762>Gluconate Dehydrogenase#P03070 HELRO|EnsemblGenome=HelroG80725|UniProtKB=T1G445 T1G445 20215843 PTHR11267:SF196 T-BOX PROTEIN-RELATED T-BOX PROTEIN 30_42-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cell fate commitment#GO:0045165;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;cell fate specification#GO:0001708;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HELRO|EnsemblGenome=HelroG191657|UniProtKB=T1FT66 T1FT66 20212013 PTHR42264:SF6 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE PROTEIN HELRO|EnsemblGenome=HelroG163594|UniProtKB=T1EU95 T1EU95 20200145 PTHR14605:SF1 CHST5 PROTEIN TRANSMEMBRANE PROTEIN 231 cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;regulation of localization#GO:0032879;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of cellular localization#GO:0060341;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;organelle assembly#GO:0070925;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;plasma membrane bounded cell projection assembly#GO:0120031;regulation of protein localization#GO:0032880 bounding membrane of organelle#GO:0098588;ciliary membrane#GO:0060170;membrane-bounded organelle#GO:0043227;plasma membrane region#GO:0098590;organelle membrane#GO:0031090;cell projection membrane#GO:0031253;cell projection#GO:0042995;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;cilium#GO:0005929;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;ciliary transition zone#GO:0035869;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG169239|UniProtKB=T1F1M2 T1F1M2 20202722 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192637|UniProtKB=T1FU54 T1FU54 20212350 PTHR24270:SF61 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 apolipoprotein#PC00052 HELRO|EnsemblGenome=HelroG188978|UniProtKB=T1FQJ0 T1FQJ0 20211087 PTHR42765:SF1 SOLEUCYL-TRNA SYNTHETASE ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG86572|UniProtKB=T1G6E1 T1G6E1 20216638 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165466|UniProtKB=T1EWU7 T1EWU7 20201047 PTHR23320:SF173 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MARVEL DOMAIN-CONTAINING PROTEIN-RELATED transporter#PC00227 HELRO|EnsemblGenome=HelroG162869|UniProtKB=T1ETA8 T1ETA8 20199808 PTHR45749:SF21 FAMILY NOT NAMED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190275|UniProtKB=T1FRU8 T1FRU8 20211545 PTHR23148:SF0 SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of RNA splicing#GO:0043484;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of mRNA processing#GO:0050684;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;regulation of mRNA metabolic process#GO:1903311 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG177423|UniProtKB=T1FBN8 T1FBN8 20206237 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165342|UniProtKB=T1EWM2 T1EWM2 20200972 PTHR43250:SF2 EXODEOXYRIBONUCLEASE III EXODEOXYRIBONUCLEASE III HELRO|EnsemblGenome=HelroG150089|UniProtKB=T1EKE4 T1EKE4 20197044 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG161704|UniProtKB=T1ERT0 T1ERT0 20199280 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG108240|UniProtKB=T1EEH6 T1EEH6 20194978 PTHR11537:SF254 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG63079|UniProtKB=T1FXA8 T1FXA8 20213456 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED single-stranded RNA binding#GO:0003727;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;poly(A) binding#GO:0008143;binding#GO:0005488;organic cyclic compound binding#GO:0097159 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG106578|UniProtKB=T1EE35 T1EE35 20194837 PTHR48083:SF35 MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED ACYL-COA DEHYDROGENASE FAMILY MEMBER 10 oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;lipid oxidation#GO:0034440;cellular metabolic process#GO:0044237;lipid catabolic process#GO:0016042;lipid modification#GO:0030258;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;fatty acid catabolic process#GO:0009062;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;fatty acid metabolic process#GO:0006631;small molecule catabolic process#GO:0044282;fatty acid beta-oxidation#GO:0006635;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;carboxylic acid metabolic process#GO:0019752;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092;oxidoreductase#PC00176 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HELRO|EnsemblGenome=HelroG119358|UniProtKB=T1EGM9 T1EGM9 20195729 PTHR15859:SF1 SETA BINDING PROTEIN 1 BTB DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG97484|UniProtKB=T1G9H1 T1G9H1 20217718 PTHR24056:SF254 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 2 transferase activity#GO:0016740;cyclin-dependent protein kinase activity#GO:0097472;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein serine/threonine kinase activity#GO:0004674;protein binding#GO:0005515;cyclin binding#GO:0030332;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 signal transduction#GO:0007165;mitotic cell cycle phase transition#GO:0044772;macromolecule modification#GO:0043412;cell cycle G1/S phase transition#GO:0044843;cell cycle process#GO:0022402;protein modification process#GO:0036211;mitotic cell cycle process#GO:1903047;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;G1/S transition of mitotic cell cycle#GO:0000082;regulation of biological process#GO:0050789;mitotic cell cycle#GO:0000278;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;phosphorylation#GO:0016310;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;regulation of cell cycle G2/M phase transition#GO:1902749;regulation of mitotic cell cycle phase transition#GO:1901990;macromolecule metabolic process#GO:0043170;regulation of cell cycle phase transition#GO:1901987;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;cell cycle phase transition#GO:0044770;primary metabolic process#GO:0044238;regulation of cell cycle process#GO:0010564;response to stimulus#GO:0050896;regulation of cellular biosynthetic process#GO:0031326;response to chemical#GO:0042221;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of G2/M transition of mitotic cell cycle#GO:0010389;regulation of mitotic cell cycle#GO:0007346;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695 non-receptor serine/threonine protein kinase#PC00167 EGF receptor signaling pathway#P00018>ERK1-2#P00543;p53 pathway#P00059>Cdc2#P04634;p53 pathway feedback loops 2#P04398>cdk2#P04653;p53 pathway#P00059>Cdk2#P04625 HELRO|EnsemblGenome=HelroG170765|UniProtKB=T1F3E3 T1F3E3 20203342 PTHR10037:SF230 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM CA[2+]-CHANNEL PROTEIN ALPHA[[1]] SUBUNIT T, ISOFORM F calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;voltage-gated channel activity#GO:0022832;sodium ion transmembrane transporter activity#GO:0015081;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated calcium channel activity#GO:0005245;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 localization#GO:0051179;calcium ion import#GO:0070509;metal ion transport#GO:0030001;establishment of localization#GO:0051234;regulation of biological quality#GO:0065008;membrane depolarization#GO:0051899;transport#GO:0006810;regulation of membrane potential#GO:0042391;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;action potential#GO:0001508;monoatomic ion transport#GO:0006811;calcium ion transport#GO:0006816 membrane protein complex#GO:0098796;sodium channel complex#GO:0034706;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron projection#GO:0043005;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell projection#GO:0042995;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG176254|UniProtKB=T1FAC2 T1FAC2 20205771 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG105246|UniProtKB=T1EDS1 T1EDS1 20194723 PTHR24155:SF11 OSTEOCLAST-STIMULATING FACTOR 1 CASKIN, ISOFORM B phosphatase binding#GO:0019902;molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;protein binding#GO:0005515;enzyme binding#GO:0019899;protein phosphatase binding#GO:0019903 signal transduction#GO:0007165;neurogenesis#GO:0022008;cell projection organization#GO:0030030;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;regulation of biological process#GO:0050789;system development#GO:0048731;cell differentiation#GO:0030154;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;axonogenesis#GO:0007409;signaling#GO:0023052;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;multicellular organism development#GO:0007275;cellular component organization#GO:0016043;cell communication#GO:0007154;cell morphogenesis#GO:0000902;cellular process#GO:0009987;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;neuron projection development#GO:0031175;enzyme-linked receptor protein signaling pathway#GO:0007167;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 anchoring junction#GO:0070161;neuron projection#GO:0043005;focal adhesion#GO:0005925;cell junction#GO:0030054;cell-substrate junction#GO:0030055;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;axon#GO:0030424 HELRO|EnsemblGenome=HelroG177732|UniProtKB=T1FC55 T1FC55 20206404 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG182148|UniProtKB=T1FHU0 T1FHU0 20208389 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178636|UniProtKB=T1FDH3 T1FDH3 20206872 PTHR15934:SF2 RNA 2',3'-CYCLIC PHOSPHODIESTERASE A-KINASE ANCHOR PROTEIN 7-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN protein kinase A binding#GO:0051018;protein kinase A regulatory subunit binding#GO:0034237;protein binding#GO:0005515;binding#GO:0005488 regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;regulation of signaling#GO:0023051;biological regulation#GO:0065007;regulation of intracellular signal transduction#GO:1902531 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG77530|UniProtKB=T1G2Z3 T1G2Z3 20215441 PTHR45881:SF6 CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED FORK-HEAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG116956|UniProtKB=T1EGI8 T1EGI8 20195690 PTHR12993:SF11 N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824 deacetylase#PC00087;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG114301|UniProtKB=T1EG07 T1EG07 20195509 PTHR23326:SF1 CCR4 NOT-RELATED CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 3 negative regulation of gene expression#GO:0010629;regulation of catabolic process#GO:0009894;heterocycle catabolic process#GO:0046700;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;nucleobase-containing compound metabolic process#GO:0006139;RNA destabilization#GO:0050779;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;regulation of biological quality#GO:0065008;nitrogen compound metabolic process#GO:0006807;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;positive regulation of mRNA catabolic process#GO:0061014;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of catabolic process#GO:0009896;mRNA destabilization#GO:0061157;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323;positive regulation of nitrogen compound metabolic process#GO:0051173;cellular aromatic compound metabolic process#GO:0006725;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;RNA metabolic process#GO:0016070;positive regulation of cellular catabolic process#GO:0031331;cellular nitrogen compound catabolic process#GO:0044270;organic cyclic compound metabolic process#GO:1901360;positive regulation of metabolic process#GO:0009893;mRNA catabolic process#GO:0006402;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;positive regulation of mRNA metabolic process#GO:1903313;heterocycle metabolic process#GO:0046483;negative regulation of biosynthetic process#GO:0009890;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of cellular catabolic process#GO:0031329;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;positive regulation of RNA metabolic process#GO:0051254 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;protein-containing complex#GO:0032991;P-body#GO:0000932;CCR4-NOT complex#GO:0030014;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular anatomical structure#GO:0005622 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG171977|UniProtKB=T1F4W8 T1F4W8 20203867 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG113667|UniProtKB=T1EFU9 T1EFU9 20195451 PTHR24058:SF28 DUAL SPECIFICITY PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE MINIBRAIN transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;peptidyl-amino acid modification#GO:0018193;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;peptidyl-threonine phosphorylation#GO:0018107;nitrogen compound metabolic process#GO:0006807;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG161979|UniProtKB=T1ES42 T1ES42 20199392 PTHR46513:SF41 VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN transmembrane signal receptor#PC00197 Wnt signaling pathway#P00057>LRP5/6#P01431 HELRO|EnsemblGenome=HelroG169153|UniProtKB=T1F1H5 T1F1H5 20202675 PTHR33395:SF21 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED PERICARDIN heart morphogenesis#GO:0003007;system development#GO:0048731;heart development#GO:0007507;circulatory system development#GO:0072359;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;animal organ development#GO:0048513;multicellular organism development#GO:0007275;developmental process#GO:0032502;animal organ morphogenesis#GO:0009887;multicellular organismal process#GO:0032501;cell adhesion#GO:0007155;cellular process#GO:0009987;post-embryonic development#GO:0009791 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG165358|UniProtKB=T1EWM8 T1EWM8 20200978 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG85008|UniProtKB=T1G5R3 T1G5R3 20216410 PTHR11049:SF24 ACYL COENZYME A THIOESTER HYDROLASE CYTOSOLIC ACYL COENZYME A THIOESTER HYDROLASE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;fatty acyl-CoA hydrolase activity#GO:0047617;catalytic activity#GO:0003824;thiolester hydrolase activity#GO:0016790 cellular aromatic compound metabolic process#GO:0006725;lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;sulfur compound metabolic process#GO:0006790;lipid catabolic process#GO:0016042;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;cellular lipid catabolic process#GO:0044242;amide metabolic process#GO:0043603;purine nucleotide metabolic process#GO:0006163;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248;oxoacid metabolic process#GO:0043436;heterocycle metabolic process#GO:0046483;acyl-CoA metabolic process#GO:0006637;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;ribonucleotide metabolic process#GO:0009259;monocarboxylic acid metabolic process#GO:0032787;fatty acid catabolic process#GO:0009062;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;fatty acid metabolic process#GO:0006631;small molecule catabolic process#GO:0044282;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;cellular lipid metabolic process#GO:0044255;carboxylic acid metabolic process#GO:0019752;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 esterase#PC00097 HELRO|EnsemblGenome=HelroG115505|UniProtKB=T1EG88 T1EG88 20195590 PTHR23512:SF3 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG172156|UniProtKB=T1F529 T1F529 20203928 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG170575|UniProtKB=T1F372 T1F372 20203271 PTHR14948:SF25 NG5 DUF4190 DOMAIN-CONTAINING PROTEIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG77994|UniProtKB=T1G363 T1G363 20215511 PTHR24070:SF263 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY RAS-RELATED PROTEIN RAP1 GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 small GTPase#PC00208;G-protein#PC00020 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Rap1#P00703;Integrin signalling pathway#P00034>Rap1#P00906;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Rap1#P00734 HELRO|EnsemblGenome=HelroG157038|UniProtKB=T1EM51 T1EM51 20197651 PTHR13162:SF8 CCR4-NOT TRANSCRIPTION COMPLEX CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1 negative regulation of gene expression#GO:0010629;regulation of catabolic process#GO:0009894;heterocycle catabolic process#GO:0046700;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;nucleobase-containing compound metabolic process#GO:0006139;RNA destabilization#GO:0050779;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;regulation of biological quality#GO:0065008;nitrogen compound metabolic process#GO:0006807;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;positive regulation of mRNA catabolic process#GO:0061014;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of catabolic process#GO:0009896;mRNA destabilization#GO:0061157;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323;positive regulation of nitrogen compound metabolic process#GO:0051173;cellular aromatic compound metabolic process#GO:0006725;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;RNA metabolic process#GO:0016070;positive regulation of cellular catabolic process#GO:0031331;cellular nitrogen compound catabolic process#GO:0044270;organic cyclic compound metabolic process#GO:1901360;positive regulation of metabolic process#GO:0009893;mRNA catabolic process#GO:0006402;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;positive regulation of mRNA metabolic process#GO:1903313;heterocycle metabolic process#GO:0046483;negative regulation of biosynthetic process#GO:0009890;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of cellular catabolic process#GO:0031329;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;positive regulation of RNA metabolic process#GO:0051254 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;protein-containing complex#GO:0032991;P-body#GO:0000932;CCR4-NOT complex#GO:0030014;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG184929|UniProtKB=T1FM63 T1FM63 20209912 PTHR13264:SF5 GCIP-INTERACTING PROTEIN P29 PRE-MRNA-SPLICING FACTOR SYF2 ribonucleoprotein complex#GO:1990904;catalytic step 2 spliceosome#GO:0071013;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;post-mRNA release spliceosomal complex#GO:0071014;spliceosomal complex#GO:0005681;Prp19 complex#GO:0000974;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG180640|UniProtKB=T1FG41 T1FG41 20207790 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG65753|UniProtKB=T1FYC4 T1FYC4 20213822 PTHR11849:SF289 ETS ETS-LIKE PROTEIN POINTED transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 PDGF signaling pathway#P00047>Ets#P01167 HELRO|EnsemblGenome=HelroG190610|UniProtKB=T1FS47 T1FS47 20211644 PTHR10350:SF6 NUCLEAR PORE COMPLEX PROTEIN NUP155 NUCLEAR PORE COMPLEX PROTEIN NUP155 structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;protein localization to nucleus#GO:0034504;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;establishment of protein localization#GO:0045184;RNA localization#GO:0006403;organic substance transport#GO:0071702;protein import into nucleus#GO:0006606;transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000972;establishment of localization#GO:0051234;RNA transport#GO:0050658;protein localization to organelle#GO:0033365;nuclear transport#GO:0051169;localization within membrane#GO:0051668;establishment of RNA localization#GO:0051236;protein localization to membrane#GO:0072657;establishment of protein localization to organelle#GO:0072594;cellular component organization#GO:0016043;cellular process#GO:0009987;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;cellular macromolecule localization#GO:0070727;nuclear export#GO:0051168;chromosome organization#GO:0051276;organelle organization#GO:0006996;nucleocytoplasmic transport#GO:0006913;nucleobase-containing compound transport#GO:0015931;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;import into nucleus#GO:0051170 envelope#GO:0031975;nuclear pore#GO:0005643;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG73540|UniProtKB=T1G1F5 T1G1F5 20214903 PTHR21222:SF1 MIT DOMAIN-CONTAINING PROTEIN 1 MIT DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG180922|UniProtKB=T1FGF2 T1FGF2 20207901 PTHR22738:SF10 RASSF RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 1 HOMOLOG regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG193292|UniProtKB=T1FUU4 T1FUU4 20212590 PTHR44170:SF6 PROTEIN SIDEKICK CONTACTIN cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG163200|UniProtKB=T1ETS5 T1ETS5 20199975 PTHR23050:SF536 CALCIUM BINDING PROTEIN EF-HAND DOMAIN-CONTAINING PROTEIN cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 calmodulin-related#PC00061 B cell activation#P00010>Calmodulin#P00375;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Calmodulin#P00755;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716;T cell activation#P00053>Calmodulin#P01305 HELRO|EnsemblGenome=HelroG172421|UniProtKB=T1F5B0 T1F5B0 20204009 PTHR47705:SF1 AGAP000321-PA PNP_UDP_1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185620|UniProtKB=T1FN19 T1FN19 20210218 PTHR24250:SF27 CHYMOTRYPSIN-RELATED ELASTASE 2 LIKE hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG157806|UniProtKB=T1EMG0 T1EMG0 20197760 PTHR10853:SF0 PELOTA PROTEIN PELOTA HOMOLOG negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;regulation of biological process#GO:0050789;ncRNA metabolic process#GO:0034660;mRNA metabolic process#GO:0016071;cellular component disassembly#GO:0022411;organic cyclic compound metabolic process#GO:1901360;mRNA catabolic process#GO:0006402;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;organic substance catabolic process#GO:1901575;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;nuclear-transcribed mRNA catabolic process#GO:0000956;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organelle disassembly#GO:1903008;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;rRNA metabolic process#GO:0016072;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 translation release factor#PC00225;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG111789|UniProtKB=T1EFE6 T1EFE6 20195298 PTHR11055:SF1 BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE PAPS SYNTHETASE, ISOFORM D transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 Sulfate assimilation#P02778>Sulfate adenylyltransferase#P03167;Sulfate assimilation#P02778>Adenylylsulfate kinase#P03164 HELRO|EnsemblGenome=HelroG104360|UniProtKB=T1EDL2 T1EDL2 20194664 PTHR23123:SF21 PHD/F-BOX CONTAINING PROTEIN JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN 1 histone modifying activity#GO:0140993;molecular adaptor activity#GO:0060090;demethylase activity#GO:0032451;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;histone demethylase activity#GO:0032452;catalytic activity#GO:0003824;protein-macromolecule adaptor activity#GO:0030674;catalytic activity, acting on a protein#GO:0140096 macromolecule modification#GO:0043412;regulation of DNA-templated transcription#GO:0006355;macromolecule metabolic process#GO:0043170;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;protein metabolic process#GO:0019538;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG163896|UniProtKB=T1EUL2 T1EUL2 20200262 PTHR24406:SF8 TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED FI01110P-RELATED nucleic acid binding#GO:0003676;protein-containing complex binding#GO:0044877;chromatin DNA binding#GO:0031490;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG157789|UniProtKB=T1EMF8 T1EMF8 20197758 PTHR24247:SF202 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE RECEPTOR 1 signaling receptor activity#GO:0038023;G protein-coupled amine receptor activity#GO:0008227;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;chemical synaptic transmission#GO:0007268;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;synaptic signaling#GO:0099536;trans-synaptic signaling#GO:0099537;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;cell-cell signaling#GO:0007267;signaling#GO:0023052 somatodendritic compartment#GO:0036477;neuron projection#GO:0043005;dendrite#GO:0030425;cell periphery#GO:0071944;dendritic tree#GO:0097447;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720 HELRO|EnsemblGenome=HelroG148863|UniProtKB=T1EKC0 T1EKC0 20197020 PTHR45771:SF6 HOMEOTIC PROTEIN DEFORMED HOMEOTIC PROTEIN SEX COMBS REDUCED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;pattern specification process#GO:0007389;positive regulation of biological process#GO:0048518;regulation of DNA-templated transcription#GO:0006355;multicellular organism development#GO:0007275;regionalization#GO:0003002;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;anatomical structure development#GO:0048856;biological regulation#GO:0065007;anterior/posterior pattern specification#GO:0009952;multicellular organismal process#GO:0032501;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG162628|UniProtKB=T1ESX9 T1ESX9 20199679 PTHR24249:SF424 HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG83337|UniProtKB=T1G543 T1G543 20216191 PTHR22847:SF637 WD40 REPEAT PROTEIN WD REPEAT DOMAIN 5B HELRO|EnsemblGenome=HelroG82517|UniProtKB=T1G4T1 T1G4T1 20216079 PTHR12560:SF0 LONGEVITY ASSURANCE FACTOR 1 LAG1 LD18904P transferase activity#GO:0016740;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;N-acyltransferase activity#GO:0016410 lipid metabolic process#GO:0006629;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;membrane lipid biosynthetic process#GO:0046467;sphingolipid metabolic process#GO:0006665;ceramide metabolic process#GO:0006672;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;membrane lipid metabolic process#GO:0006643;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;ceramide biosynthetic process#GO:0046513;cellular lipid metabolic process#GO:0044255;amide metabolic process#GO:0043603;sphingolipid biosynthetic process#GO:0030148;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG183843|UniProtKB=T1FK94 T1FK94 20209243 PTHR14024:SF49 PERILIPIN LIPID STORAGE DROPLETS SURFACE-BINDING PROTEIN 1 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG184920|UniProtKB=T1FM60 T1FM60 20209909 PTHR24068:SF74 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2-17 KDA ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E2#P01491 HELRO|EnsemblGenome=HelroG193638|UniProtKB=T1FV79 T1FV79 20212725 PTHR11232:SF2 PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER FI05246P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG155850|UniProtKB=T1ELN4 T1ELN4 20197484 PTHR10048:SF111 PHOSPHATIDYLINOSITOL KINASE PHOSPHATIDYLINOSITOL 3-KINASE AGE-1 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301;lipid kinase activity#GO:0001727 lipid metabolic process#GO:0006629;signal transduction#GO:0007165;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;glycerolipid metabolic process#GO:0046486;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular response to stimulus#GO:0051716;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;cell communication#GO:0007154;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;cell motility#GO:0048870;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0043491;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;glycerophospholipid biosynthetic process#GO:0046474;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;cell migration#GO:0016477 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;phosphatidylinositol 3-kinase complex#GO:0005942;catalytic complex#GO:1902494;transferase complex#GO:1990234;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;extrinsic component of membrane#GO:0019898 kinase#PC00137 Hypoxia response via HIF activation#P00030>PI3K#P00823;Axon guidance mediated by netrin#P00009>PI3K#P00363;Angiogenesis#P00005>PI3K#P00236;EGF receptor signaling pathway#P00018>PI3K#P00557;VEGF signaling pathway#P00056>PI3K#P01413;FGF signaling pathway#P00021>PI3K#P00640;p53 pathway feedback loops 2#P04398>PI3K#P04661;Ras Pathway#P04393>PI3K#P04567;p53 pathway#P00059>PI3K#P04609;Endothelin signaling pathway#P00019>PI3K#P00577;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PI3K#P00900;Integrin signalling pathway#P00034>PI3K#P00936 HELRO|EnsemblGenome=HelroG66676|UniProtKB=T1FYN8 T1FYN8 20213936 PTHR21229:SF2 LUNG SEVEN TRANSMEMBRANE RECEPTOR RE59932P localization#GO:0051179;establishment of localization#GO:0051234;transport#GO:0006810 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG71407|UniProtKB=T1G0K9 T1G0K9 20214607 PTHR22069:SF0 MITOCHONDRIAL RIBOSOMAL PROTEIN S18 RADIAL SPOKE HEAD PROTEIN 9 HOMOLOG cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;microtubule cytoskeleton organization#GO:0000226;microtubule-based movement#GO:0007018;cilium or flagellum-dependent cell motility#GO:0001539;cell motility#GO:0048870;cellular component organization#GO:0016043;axoneme assembly#GO:0035082;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;cilium movement involved in cell motility#GO:0060294;cilium movement#GO:0003341;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cilium-dependent cell motility#GO:0060285;microtubule-based process#GO:0007017;organelle organization#GO:0006996;microtubule bundle formation#GO:0001578;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection assembly#GO:0120031;motile cilium assembly#GO:0044458 axoneme#GO:0005930;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;plasma membrane bounded cell projection cytoplasm#GO:0032838;membrane-bounded organelle#GO:0043227;ciliary plasm#GO:0097014;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG74685|UniProtKB=T1G1U1 T1G1U1 20215039 PTHR24637:SF428 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG158631|UniProtKB=T1EN16 T1EN16 20197966 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161213|UniProtKB=T1ER79 T1ER79 20199079 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG101724|UniProtKB=T1ED64 T1ED64 20194516 PTHR43400:SF7 FUMARATE REDUCTASE FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG164619|UniProtKB=T1EVN3 T1EVN3 20200633 PTHR24180:SF45 CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED POLY [ADP-RIBOSE] POLYMERASE TANKYRASE kinase inhibitor#PC00139 HELRO|EnsemblGenome=HelroG185325|UniProtKB=T1FMP0 T1FMP0 20210089 PTHR24240:SF220 OPSIN 5-HYDROXYTRYPTAMINE RECEPTOR 1D-LIKE G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG188024|UniProtKB=T1FPK0 T1FPK0 20210747 PTHR22948:SF76 TUDOR DOMAIN CONTAINING PROTEIN FI20010P1-RELATED scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG181338|UniProtKB=T1FGW8 T1FGW8 20208067 PTHR11258:SF22 2-5 OLIGOADENYLATE SYNTHETASE MATH DOMAIN-CONTAINING PROTEIN adenylyltransferase activity#GO:0070566;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;transferase activity#GO:0016740;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772;double-stranded RNA binding#GO:0003725 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule metabolic process#GO:0060255;regulation of molecular function#GO:0065009;regulation of nitrogen compound metabolic process#GO:0051171;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 nucleotidyltransferase#PC00174 HELRO|EnsemblGenome=HelroG157436|UniProtKB=T1EMB5 T1EMB5 20197715 PTHR45673:SF1 SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;protein binding#GO:0005515;calmodulin binding#GO:0005516;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;calcium-mediated signaling#GO:0019722;regulation of cellular process#GO:0050794;calcineurin-mediated signaling#GO:0097720;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052 protein serine/threonine phosphatase complex#GO:0008287;cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 B cell activation#P00010>Calcineurin#P00386;Wnt signaling pathway#P00057>Calcineurin#P01446 HELRO|EnsemblGenome=HelroG62512|UniProtKB=T1FX17 T1FX17 20213365 PTHR10291:SF43 DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS prenyltransferase activity#GO:0004659;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824 organic hydroxy compound metabolic process#GO:1901615;lipid metabolic process#GO:0006629;alcohol biosynthetic process#GO:0046165;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;alcohol metabolic process#GO:0006066;organic hydroxy compound biosynthetic process#GO:1901617;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;isoprenoid metabolic process#GO:0006720;isoprenoid biosynthetic process#GO:0008299;primary metabolic process#GO:0044238;small molecule biosynthetic process#GO:0044283;cellular lipid metabolic process#GO:0044255;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 transferase#PC00220;acyltransferase#PC00042;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG180066|UniProtKB=T1FFF7 T1FFF7 20207556 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG184909|UniProtKB=T1FM59 T1FM59 20209908 PTHR45618:SF13 MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED MITOCHONDRIAL DICARBOXYLATE CARRIER inorganic molecular entity transmembrane transporter activity#GO:0015318;secondary active transmembrane transporter activity#GO:0015291;antiporter activity#GO:0015297;transmembrane transporter activity#GO:0022857;succinate transmembrane transporter activity#GO:0015141;carboxylic acid transmembrane transporter activity#GO:0046943;organic acid transmembrane transporter activity#GO:0005342;inorganic anion transmembrane transporter activity#GO:0015103;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 succinate transport#GO:0015744;transmembrane transport#GO:0055085;dicarboxylic acid transport#GO:0006835;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039;inorganic anion transmembrane transport#GO:0098661;localization#GO:0051179;organic substance transport#GO:0071702;phosphate ion transport#GO:0006817;establishment of localization#GO:0051234;C4-dicarboxylate transport#GO:0015740;organic acid transmembrane transport#GO:1903825;inorganic anion transport#GO:0015698 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG71353|UniProtKB=T1G0K1 T1G0K1 20214599 PTHR45701:SF3 SYNAPTOBREVIN FAMILY MEMBER SYNAPTOBREVIN syntaxin binding#GO:0019905;molecular adaptor activity#GO:0060090;protein binding#GO:0005515;SNAP receptor activity#GO:0005484;binding#GO:0005488;SNARE binding#GO:0000149;protein-macromolecule adaptor activity#GO:0030674 localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;vesicle fusion#GO:0006906;membrane fusion#GO:0061025;establishment of localization#GO:0051234;membrane organization#GO:0061024;organelle organization#GO:0006996;organelle membrane fusion#GO:0090174;transport#GO:0006810;vesicle-mediated transport#GO:0016192;vesicle organization#GO:0016050;cellular component organization#GO:0016043;cellular process#GO:0009987;organelle fusion#GO:0048284 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;SNARE complex#GO:0031201;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 Opioid proenkephalin pathway#P05915>SNARE Complex#P05986;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066;Thyrotropin-releasing hormone receptor signaling pathway#P04394>SNARE Complex#P04582;Dopamine receptor mediated signaling pathway#P05912>SNARE Complex#P05956;Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072;Beta3 adrenergic receptor signaling pathway#P04379>SNARE Complex#P04447;5HT4 type receptor mediated signaling pathway#P04376>SNARE Complex#P04428;Opioid prodynorphin pathway#P05916>SNARE Complex#P05996;Alpha adrenergic receptor signaling pathway#P00002>SNARE#P00074;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;5HT3 type receptor mediated signaling pathway#P04375>SNARE Complex#P04423;Ionotropic glutamate receptor pathway#P00037>SNARE Complex#P01013;Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049;Opioid proopiomelanocortin pathway#P05917>SNARE Complex#P06005;Beta1 adrenergic receptor signaling pathway#P04377>SNARE Complex#P04435;Cortocotropin releasing factor receptor signaling pathway#P04380>SNARE Complex#P04457;Metabotropic glutamate receptor group III pathway#P00039>SNARE Complex#P01042;Oxytocin receptor mediated signaling pathway#P04391>SNARE Complex#P04532;5HT2 type receptor mediated signaling pathway#P04374>SNARE Complex#P04415;5HT1 type receptor mediated signaling pathway#P04373>SNARE Complex#P04405;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;Beta2 adrenergic receptor signaling pathway#P04378>SNARE Complex#P04442 HELRO|EnsemblGenome=HelroG167513|UniProtKB=T1EZF9 T1EZF9 20201959 PTHR25462:SF291 BONUS, ISOFORM C-RELATED E3 UBIQUITIN-PROTEIN LIGASE TRIM45 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG70830|UniProtKB=T1G0C8 T1G0C8 20214526 PTHR16777:SF2 PROTEIN ECT2 PROTEIN ECT2 cell division#GO:0051301;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;developmental process#GO:0032502;multicellular organism development#GO:0007275;activation of GTPase activity#GO:0090630;cell cycle process#GO:0022402;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;cellular process#GO:0009987;nervous system development#GO:0007399;mitotic cell cycle process#GO:1903047;positive regulation of hydrolase activity#GO:0051345;system development#GO:0048731;mitotic cytokinesis#GO:0000281;mitotic cell cycle#GO:0000278;regulation of molecular function#GO:0065009;anatomical structure development#GO:0048856;biological regulation#GO:0065007;cytoskeleton-dependent cytokinesis#GO:0061640;cell cycle#GO:0007049;multicellular organismal process#GO:0032501;regulation of hydrolase activity#GO:0051336;cytokinesis#GO:0000910 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cell cortex#GO:0005938;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG173501|UniProtKB=T1F6W6 T1F6W6 20204565 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG114081|UniProtKB=T1EFY9 T1EFY9 20195491 PTHR11042:SF91 EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;macromolecule modification#GO:0043412;regulation of nitrogen compound metabolic process#GO:0051171;protein modification process#GO:0036211;regulation of translational initiation#GO:0006446;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;phosphorylation#GO:0016310;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;cellular process#GO:0009987;primary metabolic process#GO:0044238;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;response to stress#GO:0006950;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of translation#GO:0006417;cellular response to stress#GO:0033554;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG177465|UniProtKB=T1FBQ7 T1FBQ7 20206256 PTHR46927:SF3 AGAP005574-PA THAP-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186861|UniProtKB=T1FP42 T1FP42 20210589 PTHR22573:SF2 PHOSPHOHEXOMUTASE FAMILY MEMBER PHOSPHOGLUCOMUTASE isomerase activity#GO:0016853;intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824 carbohydrate metabolic process#GO:0005975;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 mutase#PC00160 HELRO|EnsemblGenome=HelroG185249|UniProtKB=T1FMK0 T1FMK0 20210049 PTHR11922:SF2 GMP SYNTHASE-RELATED GMP SYNTHASE [GLUTAMINE-HYDROLYZING] ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;purine ribonucleoside monophosphate metabolic process#GO:0009167;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;nucleotide biosynthetic process#GO:0009165;nucleoside monophosphate metabolic process#GO:0009123;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;purine nucleoside monophosphate metabolic process#GO:0009126;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribonucleoside monophosphate metabolic process#GO:0009161;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 De novo purine biosynthesis#P02738>GMP synthase#P02899 HELRO|EnsemblGenome=HelroG159246|UniProtKB=T1ENS8 T1ENS8 20198228 PTHR21522:SF32 PROTON CHANNEL OTOP OTOPETRIN-2 monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078;proton channel activity#GO:0015252;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;proton transmembrane transport#GO:1902600;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG192372|UniProtKB=T1FTV6 T1FTV6 20212253 PTHR14700:SF0 PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2, MITOCHONDRIAL PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2, MITOCHONDRIAL nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of nitrogen compound metabolic process#GO:0051171;developmental process#GO:0032502;multicellular organism development#GO:0007275;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of macromolecule metabolic process#GO:0060255;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of mRNA processing#GO:0050684;multicellular organismal process#GO:0032501;mitochondrion organization#GO:0007005;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;regulation of mRNA metabolic process#GO:1903311 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG165728|UniProtKB=T1EX78 T1EX78 20201178 PTHR34717:SF1 EG:BACR7A4.20 PROTEIN EG:BACR7A4.20 PROTEIN HELRO|EnsemblGenome=HelroG176625|UniProtKB=T1FAR0 T1FAR0 20205909 PTHR24115:SF344 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF28P pyrophosphatase activity#GO:0016462;cytoskeletal protein binding#GO:0008092;microtubule motor activity#GO:0003777;tubulin binding#GO:0015631;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;cytoskeletal motor activity#GO:0003774;microtubule binding#GO:0008017;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 vesicle transport along microtubule#GO:0047496;cellular localization#GO:0051641;organelle localization#GO:0051640;vesicle localization#GO:0051648;transport#GO:0006810;microtubule-based movement#GO:0007018;cellular process#GO:0009987;transport along microtubule#GO:0010970;localization#GO:0051179;microtubule-based transport#GO:0099111;establishment of localization#GO:0051234;microtubule-based process#GO:0007017;establishment of vesicle localization#GO:0051650;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;organelle transport along microtubule#GO:0072384;establishment of organelle localization#GO:0051656;vesicle cytoskeletal trafficking#GO:0099518 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;microtubule associated complex#GO:0005875;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG174345|UniProtKB=T1F811 T1F811 20204960 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG81825|UniProtKB=T1G4J2 T1G4J2 20215990 PTHR46052:SF1 PHOSDUCIN-LIKE PROTEIN PHOSDUCIN-LIKE PROTEIN HELRO|EnsemblGenome=HelroG192415|UniProtKB=T1FTX9 T1FTX9 20212276 PTHR46989:SF3 USP DOMAIN-CONTAINING PROTEIN USPA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178145|UniProtKB=T1FCU1 T1FCU1 20206640 PTHR31105:SF42 EXTRA-LARGE G-PROTEIN-LIKE OS02G0258300 PROTEIN HELRO|EnsemblGenome=HelroG193007|UniProtKB=T1FUI3 T1FUI3 20212479 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG81620|UniProtKB=T1G4G6 T1G4G6 20215964 PTHR45629:SF7 SNF2/RAD54 FAMILY MEMBER DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED damaged DNA-binding protein#PC00086;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG73990|UniProtKB=T1G1K8 T1G1K8 20214956 PTHR11247:SF1 PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1 DOLICHYLDIPHOSPHATASE 1 pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG172964|UniProtKB=T1F680 T1F680 20204329 PTHR24104:SF57 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED BEE-MILK PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG189012|UniProtKB=T1FQK1 T1FQK1 20211098 PTHR31518:SF3 ARGININE/SERINE-RICH PROTEIN PNISR ARGININE_SERINE-RICH PROTEIN PNISR HELRO|EnsemblGenome=HelroG185418|UniProtKB=T1FMS8 T1FMS8 20210127 PTHR47979:SF53 DRAB11-RELATED FI07418P GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;transport#GO:0006810 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG166228|UniProtKB=T1EXX2 T1EXX2 20201422 PTHR11616:SF321 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;organic acid:sodium symporter activity#GO:0005343;organic acid transmembrane transporter activity#GO:0005342;symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;organic anion transmembrane transporter activity#GO:0008514;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;amino acid:sodium symporter activity#GO:0005283;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;amino acid transmembrane transporter activity#GO:0015171;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;organic anion transport#GO:0015711;amino acid transport#GO:0006865;organic acid transport#GO:0015849;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;nitrogen compound transport#GO:0071705;carboxylic acid transport#GO:0046942;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;amino acid import across plasma membrane#GO:0089718;carboxylic acid transmembrane transport#GO:1905039;localization#GO:0051179;organic substance transport#GO:0071702;import across plasma membrane#GO:0098739;amino acid transmembrane transport#GO:0003333;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transport#GO:0006812;organic acid transmembrane transport#GO:1903825;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>CHT1#P01084 HELRO|EnsemblGenome=HelroG192726|UniProtKB=T1FU84 T1FU84 20212380 PTHR18884:SF126 SEPTIN SEPTIN-7 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 localization#GO:0051179;cell division#GO:0051301;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;cytoskeleton-dependent cytokinesis#GO:0061640;cell cycle process#GO:0022402;cell cycle#GO:0007049;cellular process#GO:0009987;cytokinesis#GO:0000910;protein localization#GO:0008104 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;cell division site#GO:0032153;cell cortex#GO:0005938;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG156778|UniProtKB=T1EM09 T1EM09 20197609 PTHR24078:SF553 DNAJ HOMOLOG SUBFAMILY C MEMBER DNAJ HOMOLOG SUBFAMILY B MEMBER 5 protein binding#GO:0005515;protein-folding chaperone binding#GO:0051087;unfolded protein binding#GO:0051082;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;chaperone-mediated protein folding#GO:0061077;chaperone cofactor-dependent protein refolding#GO:0051085;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;'de novo' protein folding#GO:0006458;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG159817|UniProtKB=T1EPF8 T1EPF8 20198458 PTHR10221:SF22 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6 TAF6-LIKE RNA POLYMERASE II P300_CBP-ASSOCIATED FACTOR-ASSOCIATED FACTOR 65 KDA SUBUNIT 6L transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;RNA metabolic process#GO:0016070;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;RNA polymerase II preinitiation complex assembly#GO:0051123;transcription initiation at RNA polymerase II promoter#GO:0006367;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;DNA-directed RNA polymerase complex#GO:0000428;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nucleoplasm#GO:0005654;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;transcription factor TFIID complex#GO:0005669;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;transcription regulator complex#GO:0005667;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG67319|UniProtKB=T1FYZ6 T1FYZ6 20214044 PTHR11850:SF295 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS ACHINTYA, ISOFORM C-RELATED DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG85810|UniProtKB=T1G629 T1G629 20216526 PTHR12259:SF1 RGS-GAIP INTERACTING PROTEIN GIPC GH21964P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG66818|UniProtKB=T1FYR4 T1FYR4 20213962 PTHR24210:SF0 LIM DOMAIN-CONTAINING PROTEIN LIM DOMAIN-CONTAINING PROTEIN cell junction protein#PC00070 Integrin signalling pathway#P00034>PINCH#P00921 HELRO|EnsemblGenome=HelroG159295|UniProtKB=T1ENU7 T1ENU7 20198247 PTHR12713:SF11 VACUOLAR ATP SYNTHASE SUBUNIT G V-TYPE PROTON ATPASE SUBUNIT G inorganic molecular entity transmembrane transporter activity#GO:0015318;catalytic activity#GO:0003824;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887;ATPase-coupled transmembrane transporter activity#GO:0042626;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;pyrophosphatase activity#GO:0016462;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;proton transmembrane transporter activity#GO:0015078;hydrolase activity#GO:0016787;active monoatomic ion transmembrane transporter activity#GO:0022853;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;vacuolar membrane#GO:0005774;ATPase complex#GO:1904949;vacuole#GO:0005773;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;proton-transporting two-sector ATPase complex#GO:0016469;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG157415|UniProtKB=T1EMB1 T1EMB1 20197711 PTHR11767:SF102 INWARD RECTIFIER POTASSIUM CHANNEL INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of localization#GO:0032879;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;import across plasma membrane#GO:0098739;regulation of transport#GO:0051049;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;regulation of monoatomic ion transport#GO:0043269;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;potassium ion transport#GO:0006813;potassium ion import across plasma membrane#GO:1990573 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG177816|UniProtKB=T1FCB4 T1FCB4 20206463 PTHR12242:SF45 OS02G0130600 PROTEIN-RELATED MARVEL DOMAIN-CONTAINING PROTEIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG134261|UniProtKB=T1EI37 T1EI37 20196237 PTHR14057:SF47 TRANSCRIPTION FACTOR ONECUT HOMEOBOX PROTEIN ONECUT sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG184679|UniProtKB=T1FLR2 T1FLR2 20209761 PTHR28643:SF1 SWI5-DEPENDENT RECOMBINATION DNA REPAIR PROTEIN 1 HOMOLOG SWI5-DEPENDENT RECOMBINATION DNA REPAIR PROTEIN 1 HOMOLOG transcription coactivator activity#GO:0003713;nuclear receptor coactivator activity#GO:0030374;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;positive regulation of nitrogen compound metabolic process#GO:0051173;double-strand break repair#GO:0006302;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of RNA biosynthetic process#GO:2001141;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;DNA damage response#GO:0006974;positive regulation of metabolic process#GO:0009893;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;recombinational repair#GO:0000725;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;regulation of DNA-templated transcription#GO:0006355;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;positive regulation of cellular biosynthetic process#GO:0031328;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;double-strand break repair via homologous recombination#GO:0000724;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;positive regulation of RNA metabolic process#GO:0051254;cellular response to stress#GO:0033554;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;chromatin#GO:0000785;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG110309|UniProtKB=T1EF12 T1EF12 20195164 PTHR24023:SF1019 COLLAGEN ALPHA COLLAGEN ALPHA-5(IV) CHAIN ISOFORM X1 structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922 HELRO|EnsemblGenome=HelroG91560|UniProtKB=T1G854 T1G854 20217251 PTHR13363:SF6 RING FINGER AND SRY DOMAIN-CONTAINING RING FINGER AND SPRY DOMAIN-CONTAINING PROTEIN 1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787 macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;catabolic process#GO:0009056;organonitrogen compound catabolic process#GO:1901565;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG78007|UniProtKB=T1G366 T1G366 20215514 PTHR10362:SF7 HISTIDINE AMMONIA-LYASE HISTIDINE AMMONIA-LYASE lyase activity#GO:0016829;catalytic activity#GO:0003824 lyase#PC00144 HELRO|EnsemblGenome=HelroG163274|UniProtKB=T1ETV1 T1ETV1 20200001 PTHR14939:SF5 F-BOX ONLY PROTEIN 22 F-BOX ONLY PROTEIN 22 HELRO|EnsemblGenome=HelroG184905|UniProtKB=T1FM56 T1FM56 20209905 PTHR10809:SF6 VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN AT11025P-RELATED localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organelle localization#GO:0051640;endoplasmic reticulum organization#GO:0007029;membrane organization#GO:0061024;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;plasma membrane#GO:0005886;endoplasmic reticulum membrane#GO:0005789 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG168181|UniProtKB=T1F097 T1F097 20202247 PTHR47202:SF2 HISTIDINE-RICH GLYCOPROTEIN G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194326|UniProtKB=T1FVX8 T1FVX8 20212974 PTHR21677:SF1 CRAMPED PROTEIN PROTEIN CRAMPED-LIKE protein-containing complex binding#GO:0044877;binding#GO:0005488;chromatin binding#GO:0003682 multicellular organismal process#GO:0032501;pattern specification process#GO:0007389;anatomical structure development#GO:0048856;multicellular organism development#GO:0007275;developmental process#GO:0032502 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG190695|UniProtKB=T1FS76 T1FS76 20211673 PTHR14689:SF0 PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN COILED-COIL DOMAIN-CONTAINING PROTEIN 82 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG108080|UniProtKB=T1EEF1 T1EEF1 20194953 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG170102|UniProtKB=T1F2M6 T1F2M6 20203075 PTHR46644:SF2 DNA REPAIR PROTEIN XRCC2 DNA REPAIR PROTEIN XRCC2 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG194331|UniProtKB=T1FVY1 T1FVY1 20212977 PTHR15495:SF7 NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED GPI INOSITOL-DEACYLASE hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;lipid metabolic process#GO:0006629;cellular localization#GO:0051641;carbohydrate derivative metabolic process#GO:1901135;transport#GO:0006810;glycolipid metabolic process#GO:0006664;vesicle-mediated transport#GO:0016192;cellular metabolic process#GO:0044237;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;liposaccharide metabolic process#GO:1903509;Golgi vesicle transport#GO:0048193;GPI anchor metabolic process#GO:0006505;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;localization#GO:0051179;glycerolipid metabolic process#GO:0046486;membrane lipid metabolic process#GO:0006643;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;organophosphate metabolic process#GO:0019637;intracellular transport#GO:0046907;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG171029|UniProtKB=T1F3Q5 T1F3Q5 20203454 PTHR24410:SF23 HL07962P-RELATED BTB DOMAIN-CONTAINING PROTEIN-RELATED defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG89197|UniProtKB=T1G7A1 T1G7A1 20216948 PTHR24055:SF598 MITOGEN-ACTIVATED PROTEIN KINASE STRESS-ACTIVATED PROTEIN KINASE JNK transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Integrin signalling pathway#P00034>Jnk#P00951;TGF-beta signaling pathway#P00052>JNK#P01284;Oxidative stress response#P00046>JNK1/2#P01129;Ras Pathway#P04393>JNK#P04572;Angiogenesis#P00005>JNK1#P00221;Interferon-gamma signaling pathway#P00035>Serine kinase#P00955;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;EGF receptor signaling pathway#P00018>JNK1-3#P00545;Apoptosis signaling pathway#P00006>JNK#P00274;Toll receptor signaling pathway#P00054>JNK#P01375;Parkinson disease#P00049>SAPK#P01219;FGF signaling pathway#P00021>JNK1-3#P00628;FAS signaling pathway#P00020>JNK#P00615 HELRO|EnsemblGenome=HelroG78406|UniProtKB=T1G3B5 T1G3B5 20215563 PTHR12377:SF2 CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2A macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;gene expression#GO:0010467;protein maturation#GO:0051604;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;primary metabolic process#GO:0044238 HELRO|EnsemblGenome=HelroG176119|UniProtKB=T1FA59 T1FA59 20205708 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188109|UniProtKB=T1FPN3 T1FPN3 20210780 PTHR47537:SF2 CUBILIN CUBILIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG177544|UniProtKB=T1FBV1 T1FBV1 20206300 PTHR45749:SF21 FAMILY NOT NAMED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167918|UniProtKB=T1EZY6 T1EZY6 20202136 PTHR24249:SF424 HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG188102|UniProtKB=T1FPM9 T1FPM9 20210776 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG133549|UniProtKB=T1EI13 T1EI13 20196213 PTHR12416:SF3 RRNA-PROCESSING PROTEIN UTP23 HOMOLOG RRNA-PROCESSING PROTEIN UTP23 HOMOLOG HELRO|EnsemblGenome=HelroG72757|UniProtKB=T1G151 T1G151 20214799 PTHR45689:SF5 I[[H]] CHANNEL, ISOFORM E I[[H]] CHANNEL, ISOFORM E monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;sodium ion transport#GO:0006814;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;regulation of membrane depolarization#GO:0003254;sodium ion transmembrane transport#GO:0035725;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG183751|UniProtKB=T1FK52 T1FK52 20209201 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164066|UniProtKB=T1EUV2 T1EUV2 20200352 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG95727|UniProtKB=T1G971 T1G971 20217618 PTHR10177:SF593 CYCLINS G2_MITOTIC-SPECIFIC CYCLIN-A protein kinase regulator activity#GO:0019887;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 regulation of protein kinase activity#GO:0045859;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;mitotic cell cycle phase transition#GO:0044772;regulation of nitrogen compound metabolic process#GO:0051171;cell cycle process#GO:0022402;regulation of catalytic activity#GO:0050790;cellular process#GO:0009987;cell cycle phase transition#GO:0044770;mitotic cell cycle process#GO:1903047;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;regulation of primary metabolic process#GO:0080090;mitotic cell cycle#GO:0000278;regulation of macromolecule metabolic process#GO:0060255;regulation of molecular function#GO:0065009;regulation of protein phosphorylation#GO:0001932;regulation of cellular process#GO:0050794;regulation of protein serine/threonine kinase activity#GO:0071900;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cyclin-dependent protein serine/threonine kinase activity#GO:0000079;regulation of kinase activity#GO:0043549;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622 kinase activator#PC00138 HELRO|EnsemblGenome=HelroG160537|UniProtKB=T1EQD8 T1EQD8 20198788 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG85270|UniProtKB=T1G5U9 T1G5U9 20216446 PTHR11005:SF161 LYSOSOMAL ACID LIPASE-RELATED LIPASE lipase#PC00143;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG193762|UniProtKB=T1FVC1 T1FVC1 20212767 PTHR13328:SF6 NEGATIVE ELONGATION FACTOR A NELF-A GEX-3-INTERACTING PROTEIN 13 regulation of DNA-templated transcription elongation#GO:0032784;regulation of transcription elongation by RNA polymerase II#GO:0034243;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;transcription elongation factor complex#GO:0008023;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG102639|UniProtKB=T1EDA7 T1EDA7 20194559 PTHR22763:SF184 RING ZINC FINGER PROTEIN E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 response to organic substance#GO:0010033;macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;response to organonitrogen compound#GO:0010243;ERAD pathway#GO:0036503;cellular process#GO:0009987;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;response to nitrogen compound#GO:1901698;modification-dependent macromolecule catabolic process#GO:0043632;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG183308|UniProtKB=T1FJF9 T1FJF9 20208958 PTHR12766:SF7 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DEATH DOMAIN-ASSOCIATED PROTEIN 6 FAS signaling pathway#P00020>DAXX#P00602;Apoptosis signaling pathway#P00006>DAXX#P00296 HELRO|EnsemblGenome=HelroG83432|UniProtKB=T1G555 T1G555 20216203 PTHR12787:SF0 RIBOSOMAL RNA-PROCESSING PROTEIN 8 RIBOSOMAL RNA-PROCESSING PROTEIN 8 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG184465|UniProtKB=T1FL93 T1FL93 20209592 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG83529|UniProtKB=T1G567 T1G567 20216215 PTHR24031:SF91 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX24 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG100818|UniProtKB=T1ED17 T1ED17 20194469 PTHR11210:SF1 RING BOX ANAPHASE-PROMOTING COMPLEX SUBUNIT 11 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;cullin family protein binding#GO:0097602;protein binding#GO:0005515;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 regulation of mitotic nuclear division#GO:0007088;regulation of chromosome segregation#GO:0051983;positive regulation of organelle organization#GO:0010638;macromolecule modification#GO:0043412;regulation of chromosome separation#GO:1905818;protein catabolic process#GO:0030163;organonitrogen compound catabolic process#GO:1901565;protein modification process#GO:0036211;regulation of cellular component organization#GO:0051128;positive regulation of cell cycle#GO:0045787;post-translational protein modification#GO:0043687;modification-dependent macromolecule catabolic process#GO:0043632;regulation of biological process#GO:0050789;nitrogen compound metabolic process#GO:0006807;positive regulation of cell cycle process#GO:0090068;positive regulation of mitotic cell cycle#GO:0045931;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;positive regulation of biological process#GO:0048518;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;regulation of chromosome organization#GO:0033044;macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;regulation of mitotic sister chromatid separation#GO:0010965;regulation of nuclear division#GO:0051783;protein modification by small protein conjugation or removal#GO:0070647;regulation of mitotic cell cycle phase transition#GO:1901990;macromolecule metabolic process#GO:0043170;regulation of organelle organization#GO:0033043;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;positive regulation of mitotic nuclear division#GO:0045840;regulation of cell cycle phase transition#GO:1901987;organonitrogen compound metabolic process#GO:1901564;regulation of mitotic metaphase/anaphase transition#GO:0030071;primary metabolic process#GO:0044238;regulation of cell cycle process#GO:0010564;positive regulation of cellular process#GO:0048522;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;regulation of cell cycle#GO:0051726;regulation of sister chromatid segregation#GO:0033045;regulation of mitotic cell cycle#GO:0007346 ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234;anaphase-promoting complex#GO:0005680;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG171604|UniProtKB=T1F4G2 T1F4G2 20203711 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178715|UniProtKB=T1FDM1 T1FDM1 20206920 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174388|UniProtKB=T1F826 T1F826 20204975 PTHR47027:SF20 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN HELRO|EnsemblGenome=HelroG108967|UniProtKB=T1EEP4 T1EEP4 20195046 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG101510|UniProtKB=T1ED51 T1ED51 20194503 PTHR13803:SF39 SEC24-RELATED PROTEIN SECRETORY 24AB, ISOFORM A cation binding#GO:0043169;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;binding#GO:0005488;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;protein binding#GO:0005515;ion binding#GO:0043167;SNARE binding#GO:0000149 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;membrane organization#GO:0061024;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;vesicle budding from membrane#GO:0006900;organelle organization#GO:0006996;COPII-coated vesicle budding#GO:0090114;establishment of localization in cell#GO:0051649;vesicle organization#GO:0016050;intracellular transport#GO:0046907 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;ER to Golgi transport vesicle membrane#GO:0012507;endoplasmic reticulum exit site#GO:0070971;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;vesicle coat#GO:0030120;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;transport vesicle membrane#GO:0030658;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane coat#GO:0030117;coated vesicle membrane#GO:0030662;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;coated membrane#GO:0048475;cytoplasmic vesicle membrane#GO:0030659;endoplasmic reticulum#GO:0005783 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG191479|UniProtKB=T1FT08 T1FT08 20211955 PTHR13817:SF166 TITIN NEURONAL IGCAM-RELATED structural protein#PC00211 HELRO|EnsemblGenome=HelroG113658|UniProtKB=T1EFU7 T1EFU7 20195449 PTHR10160:SF19 NAD(P) TRANSHYDROGENASE PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;oxidoreductase activity, acting on NAD(P)H#GO:0016651;oxidoreductase activity#GO:0016491 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;generation of precursor metabolites and energy#GO:0006091;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;pyridine nucleotide metabolic process#GO:0019362;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;NADP metabolic process#GO:0006739;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG187113|UniProtKB=T1FP71 T1FP71 20210618 PTHR42807:SF1 GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG95955|UniProtKB=T1G990 T1G990 20217637 PTHR19957:SF411 SYNTAXIN LD23667P molecular adaptor activity#GO:0060090;protein binding#GO:0005515;SNAP receptor activity#GO:0005484;binding#GO:0005488;SNARE binding#GO:0000149;protein-macromolecule adaptor activity#GO:0030674 vesicle fusion#GO:0006906;cellular localization#GO:0051641;organelle localization#GO:0051640;macromolecule localization#GO:0033036;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;membrane fusion#GO:0061025;establishment of localization#GO:0051234;organelle organization#GO:0006996;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;vesicle organization#GO:0016050;intracellular transport#GO:0046907;organelle fusion#GO:0048284 presynapse#GO:0098793;membrane protein complex#GO:0098796;synapse#GO:0045202;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;SNARE complex#GO:0031201;cell junction#GO:0030054;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;secretory vesicle#GO:0099503 SNARE protein#PC00034;membrane traffic protein#PC00150 Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072;Parkinson disease#P00049>Syntaxin#P01215 HELRO|EnsemblGenome=HelroG106710|UniProtKB=T1EE39 T1EE39 20194841 PTHR10183:SF379 CALPAIN CALPAIN-5 cysteine protease#PC00081;protease#PC00190 Huntington disease#P00029>Calpain#P00788 HELRO|EnsemblGenome=HelroG162503|UniProtKB=T1ESR5 T1ESR5 20199615 PTHR33604:SF3 OSJNBA0004B13.7 PROTEIN OSJNBA0004B13.7 PROTEIN HELRO|EnsemblGenome=HelroG160458|UniProtKB=T1EQ99 T1EQ99 20198749 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184429|UniProtKB=T1FL68 T1FL68 20209567 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185661|UniProtKB=T1FN38 T1FN38 20210236 PTHR24055:SF599 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE ERK-A transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 EGF receptor signaling pathway#P00018>ERK1-2#P00543;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>MAPK#P00835;FGF signaling pathway#P00021>ERK1-2#P00627;Interferon-gamma signaling pathway#P00035>Serine kinase#P00955;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;Apoptosis signaling pathway#P00006>MAPK#P00269;TGF-beta signaling pathway#P00052>p42/p44MAPKs#P01293;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>ERK#P00889;Parkinson disease#P00049>ERK#P01211;Endothelin signaling pathway#P00019>ERK#P00566 HELRO|EnsemblGenome=HelroG192402|UniProtKB=T1FTW9 T1FTW9 20212266 PTHR45762:SF3 ZINC FINGER RNA-BINDING PROTEIN ZINC-FINGER PROTEIN AT 72D, ISOFORM B RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG152427|UniProtKB=T1EKR8 T1EKR8 20197168 PTHR24333:SF5 HOMEO BOX HB9 LIKE A-RELATED VENT HOMEOBOX homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG192219|UniProtKB=T1FTQ3 T1FTQ3 20212200 PTHR11683:SF12 MYELIN PROTEOLIPID M6, ISOFORM F cellular developmental process#GO:0048869;neurogenesis#GO:0022008;cell projection organization#GO:0030030;multicellular organism development#GO:0007275;developmental process#GO:0032502;cellular component organization#GO:0016043;cellular process#GO:0009987;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;system development#GO:0048731;neuron projection development#GO:0031175;cell differentiation#GO:0030154;anatomical structure development#GO:0048856;neuron differentiation#GO:0030182;neuron development#GO:0048666;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 myelin protein#PC00161 HELRO|EnsemblGenome=HelroG185261|UniProtKB=T1FMK6 T1FMK6 20210055 PTHR11977:SF130 VILLIN SEVERIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;actin polymerization or depolymerization#GO:0008154;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG72558|UniProtKB=T1G118 T1G118 20214766 PTHR11011:SF116 MALE STERILITY PROTEIN 2-RELATED FATTY ACYL-COA REDUCTASE CG5065-RELATED oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;lipid metabolic process#GO:0006629;heterocycle metabolic process#GO:0046483;carbohydrate derivative metabolic process#GO:1901135;sulfur compound metabolic process#GO:0006790;acyl-CoA metabolic process#GO:0006637;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;amide metabolic process#GO:0043603;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;nucleobase-containing small molecule metabolic process#GO:0055086 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;microbody#GO:0042579;membrane-bounded organelle#GO:0043227;peroxisome#GO:0005777;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG179973|UniProtKB=T1FFA6 T1FFA6 20207505 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174271|UniProtKB=T1F7X2 T1F7X2 20204921 PTHR46954:SF1 C2H2-TYPE DOMAIN-CONTAINING PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG91978|UniProtKB=T1G8B2 T1G8B2 20217309 PTHR21442:SF0 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206 biological regulation#GO:0065007;regulation of biological process#GO:0050789;regulation of microtubule-based process#GO:0032886;regulation of cellular process#GO:0050794 axoneme#GO:0005930;microtubule organizing center#GO:0005815;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;plasma membrane bounded cell projection cytoplasm#GO:0032838;ciliary plasm#GO:0097014;cell projection#GO:0042995;cytoskeleton#GO:0005856;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG115304|UniProtKB=T1EG74 T1EG74 20195576 PTHR23123:SF35 PHD/F-BOX CONTAINING PROTEIN F-BOX_LRR-REPEAT PROTEIN 19 histone modifying activity#GO:0140993;molecular adaptor activity#GO:0060090;demethylase activity#GO:0032451;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;histone demethylase activity#GO:0032452;catalytic activity#GO:0003824;protein-macromolecule adaptor activity#GO:0030674;catalytic activity, acting on a protein#GO:0140096 macromolecule modification#GO:0043412;regulation of DNA-templated transcription#GO:0006355;macromolecule metabolic process#GO:0043170;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;protein metabolic process#GO:0019538;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG192497|UniProtKB=T1FU10 T1FU10 20212306 PTHR42264:SF3 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN F-BOX DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG171812|UniProtKB=T1F4Q3 T1F4Q3 20203802 PTHR47055:SF3 DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 HELRO|EnsemblGenome=HelroG173504|UniProtKB=T1F6W7 T1F6W7 20204566 PTHR47537:SF2 CUBILIN CUBILIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG164457|UniProtKB=T1EVF9 T1EVF9 20200559 PTHR47055:SF3 DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 HELRO|EnsemblGenome=HelroG161971|UniProtKB=T1ES39 T1ES39 20199389 PTHR48209:SF3 AGL056WP SYNDECAN_NEUREXIN DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163366|UniProtKB=T1ETY5 T1ETY5 20200035 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG191051|UniProtKB=T1FSJ6 T1FSJ6 20211793 PTHR46641:SF25 FMRFAMIDE RECEPTOR-RELATED CNMAMIDE RECEPTOR-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG90406|UniProtKB=T1G7Q9 T1G7Q9 20217106 PTHR23333:SF20 UBX DOMAIN CONTAINING PROTEIN NSFL1 COFACTOR P47 protein binding#GO:0005515;ubiquitin-like protein binding#GO:0032182;binding#GO:0005488;ubiquitin binding#GO:0043130 cellular component biogenesis#GO:0044085;macroautophagy#GO:0016236;membrane organization#GO:0061024;protein catabolic process#GO:0030163;nucleus organization#GO:0006997;endomembrane system organization#GO:0010256;organonitrogen compound catabolic process#GO:1901565;modification-dependent macromolecule catabolic process#GO:0043632;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;membrane assembly#GO:0071709;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;nuclear membrane organization#GO:0071763;cellular catabolic process#GO:0044248;cellular component assembly#GO:0022607;macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;Golgi organization#GO:0007030;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;membrane fusion#GO:0061025;organelle organization#GO:0006996;autophagosome assembly#GO:0000045;nuclear envelope organization#GO:0006998;autophagy#GO:0006914 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG168918|UniProtKB=T1F146 T1F146 20202546 PTHR24351:SF234 RIBOSOMAL PROTEIN S6 KINASE SERINE_THREONINE-PROTEIN KINASE YPK2_YKR2 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG177338|UniProtKB=T1FBJ1 T1FBJ1 20206190 PTHR45784:SF5 C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED HELRO|EnsemblGenome=HelroG71648|UniProtKB=T1G0P8 T1G0P8 20214646 PTHR14614:SF109 HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG89456|UniProtKB=T1G7D1 T1G7D1 20216978 PTHR43591:SF24 METHYLTRANSFERASE 2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL methyltransferase activity#GO:0008168;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824 methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG113524|UniProtKB=T1EFT1 T1EFT1 20195433 PTHR19139:SF199 AQUAPORIN TRANSPORTER MIP17260P cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG113361|UniProtKB=T1EFR7 T1EFR7 20195419 PTHR23044:SF61 3'-5' EXONUCLEASE ERI1-RELATED 3'-5' EXORIBONUCLEASE 1-RELATED RNA metabolism protein#PC00031;exoribonuclease#PC00099 HELRO|EnsemblGenome=HelroG138322|UniProtKB=T1EIT6 T1EIT6 20196486 PTHR10083:SF381 KUNITZ-TYPE PROTEASE INHIBITOR-RELATED BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN peptidase inhibitor activity#GO:0030414;molecular function regulator activity#GO:0098772;serine-type endopeptidase inhibitor activity#GO:0004867;peptidase regulator activity#GO:0061134;enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;endopeptidase regulator activity#GO:0061135;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG193451|UniProtKB=T1FV00 T1FV00 20212646 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG132019|UniProtKB=T1EHX1 T1EHX1 20196171 PTHR24056:SF246 CELL DIVISION PROTEIN KINASE ECDYSONE-INDUCED PROTEIN 63E, ISOFORM N cyclin-dependent protein kinase activity#GO:0097472;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG86266|UniProtKB=T1G696 T1G696 20216593 PTHR24179:SF29 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12 LD46604P phosphatase regulator activity#GO:0019208;enzyme inhibitor activity#GO:0004857;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG73543|UniProtKB=T1G1F7 T1G1F7 20214905 PTHR12413:SF1 DOLICHYL GLYCOSYLTRANSFERASE DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE glucosyltransferase activity#GO:0046527;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;cellular lipid metabolic process#GO:0044255;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG170315|UniProtKB=T1F2X0 T1F2X0 20203169 PTHR10027:SF33 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic ion-gated channel activity#GO:0022839;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium-activated cation channel activity#GO:0005227;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG180002|UniProtKB=T1FFB7 T1FFB7 20207516 PTHR11905:SF247 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG189835|UniProtKB=T1FRE6 T1FRE6 20211393 PTHR10075:SF100 BASIGIN RELATED FASCICLIN-2 cell adhesion molecule binding#GO:0050839;cell-cell adhesion mediator activity#GO:0098632;protein binding#GO:0005515;binding#GO:0005488 neuron projection guidance#GO:0097485;cell recognition#GO:0008037;neurogenesis#GO:0022008;cell projection organization#GO:0030030;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;axonogenesis#GO:0007409;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156;cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cell morphogenesis#GO:0000902;cellular process#GO:0009987;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure development#GO:0048856;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;axon#GO:0030424 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG191626|UniProtKB=T1FT53 T1FT53 20212000 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG62198|UniProtKB=T1FWW9 T1FWW9 20213317 PTHR20967:SF0 PROHORMONE-4 PROHORMONE-4 HELRO|EnsemblGenome=HelroG167896|UniProtKB=T1EZX7 T1EZX7 20202127 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG81535|UniProtKB=T1G4F5 T1G4F5 20215953 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG186003|UniProtKB=T1FNJ3 T1FNJ3 20210390 PTHR23428:SF349 HISTONE H2B HISTONE H2B chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG173319|UniProtKB=T1F6N9 T1F6N9 20204488 PTHR23261:SF77 GROUNDHOG-RELATED GROUND-LIKE DOMAIN-CONTAINING PROTEIN intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG121337|UniProtKB=T1EGR4 T1EGR4 20195764 PTHR11537:SF113 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;delayed rectifier potassium channel activity#GO:0005251;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG189234|UniProtKB=T1FQU4 T1FQU4 20211191 PTHR11533:SF301 PROTEASE M1 ZINC METALLOPROTEASE AMINOPEPTIDASE metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;amide binding#GO:0033218;metal ion binding#GO:0046872;peptidase activity#GO:0008233;metalloaminopeptidase activity#GO:0070006;cation binding#GO:0043169;peptide binding#GO:0042277;hydrolase activity#GO:0016787;aminopeptidase activity#GO:0004177;exopeptidase activity#GO:0008238;ion binding#GO:0043167;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;peptide catabolic process#GO:0043171;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;membrane#GO:0016020;extracellular region#GO:0005576;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG178761|UniProtKB=T1FDP4 T1FDP4 20206943 PTHR14445:SF36 GRB10 INTERACTING GYF PROTEIN FI03272P-RELATED cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG155421|UniProtKB=T1ELI3 T1ELI3 20197433 PTHR13505:SF7 TRANSMEMBRANE PROTEIN 208 TRANSMEMBRANE PROTEIN 208 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG156683|UniProtKB=T1ELZ9 T1ELZ9 20197599 PTHR10218:SF302 GTP-BINDING PROTEIN ALPHA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;ribonucleoside triphosphate phosphatase activity#GO:0017111;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 regulation of biological process#GO:0050789;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;side of membrane#GO:0098552;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;extrinsic component of membrane#GO:0019898 heterotrimeric G-protein#PC00117;G-protein#PC00020 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Galphai#P00828;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Galphai/q#P00873 HELRO|EnsemblGenome=HelroG93501|UniProtKB=T1G8W1 T1G8W1 20217508 PTHR12730:SF0 HSDA/SDA1-RELATED PROTEIN SDA1 HOMOLOG cellular component biogenesis#GO:0044085;ribosomal subunit export from nucleus#GO:0000054;cellular localization#GO:0051641;organelle localization#GO:0051640;transport#GO:0006810;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;ribonucleoprotein complex biogenesis#GO:0022613;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;ribosome biogenesis#GO:0042254;nuclear transport#GO:0051169;establishment of organelle localization#GO:0051656;protein-containing complex localization#GO:0031503 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG169882|UniProtKB=T1F2E4 T1F2E4 20202994 PTHR15504:SF0 NASOPHARYNGEAL EPITHELIUM SPECIFIC PROTEIN 1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 45 HELRO|EnsemblGenome=HelroG67514|UniProtKB=T1FZ20 T1FZ20 20214068 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cell communication#GO:0007154;cellular process#GO:0009987;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;Notch signaling pathway#GO:0007219 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG174776|UniProtKB=T1F8G5 T1F8G5 20205114 PTHR15090:SF0 SEQUESTOSOME 1-RELATED SEQUESTOSOME-1 K63-linked polyubiquitin modification-dependent protein binding#GO:0070530;binding#GO:0005488;protein binding#GO:0005515;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;modification-dependent protein binding#GO:0140030;polyubiquitin modification-dependent protein binding#GO:0031593;kinase binding#GO:0019900 macroautophagy#GO:0016236;mitophagy#GO:0000423;endomembrane system organization#GO:0010256;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;autophagy of mitochondrion#GO:0000422;cellular process#GO:0009987;organelle disassembly#GO:1903008;process utilizing autophagic mechanism#GO:0061919;cellular component organization or biogenesis#GO:0071840;endosome organization#GO:0007032;cellular component disassembly#GO:0022411;organelle organization#GO:0006996;catabolic process#GO:0009056;vesicle organization#GO:0016050;mitochondrion organization#GO:0007005;autophagy#GO:0006914;metabolic process#GO:0008152;cellular catabolic process#GO:0044248 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;autophagosome#GO:0005776;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG175342|UniProtKB=T1F963 T1F963 20205362 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG190662|UniProtKB=T1FS68 T1FS68 20211665 PTHR24215:SF37 RHO-GTPASE-ACTIVATING PROTEIN LRG1 LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;organelle organization#GO:0006996 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG120633|UniProtKB=T1EGQ3 T1EGQ3 20195753 PTHR24241:SF76 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR NEUROPEPTIDE SIFAMIDE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;binding#GO:0005488;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888;amide binding#GO:0033218 response to organic substance#GO:0010033;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;response to hormone#GO:0009725;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG184866|UniProtKB=T1FM36 T1FM36 20209885 PTHR10956:SF0 60S RIBOSOMAL PROTEIN L31 60S RIBOSOMAL PROTEIN L31 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cytoplasmic translation#GO:0002181;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG89615|UniProtKB=T1G7E9 T1G7E9 20216996 PTHR21236:SF1 GOLGI MEMBRANE PROTEIN YIP1 PROTEIN YIPF6 cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi apparatus subcompartment#GO:0098791;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 structural protein#PC00211 HELRO|EnsemblGenome=HelroG184275|UniProtKB=T1FKW5 T1FKW5 20209464 PTHR33332:SF48 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179953|UniProtKB=T1FFA2 T1FFA2 20207501 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG108064|UniProtKB=T1EEE9 T1EEE9 20194951 PTHR45976:SF1 ARMADILLO SEGMENT POLARITY PROTEIN ARMADILLO SEGMENT POLARITY PROTEIN phosphatase binding#GO:0019902;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;nuclear receptor binding#GO:0016922;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;cell adhesion molecule binding#GO:0050839;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;enzyme binding#GO:0019899;protein binding#GO:0005515;protein phosphatase binding#GO:0019903;transcription factor binding#GO:0008134;DNA-binding transcription factor binding#GO:0140297 positive regulation of nitrogen compound metabolic process#GO:0051173;signal transduction#GO:0007165;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;cell-cell signaling#GO:0007267;signaling#GO:0023052;canonical Wnt signaling pathway#GO:0060070;Wnt signaling pathway#GO:0016055;cellular response to stimulus#GO:0051716;regulation of DNA-templated transcription#GO:0006355;cell-cell adhesion#GO:0098609;cell communication#GO:0007154;cell adhesion#GO:0007155;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;cell-cell signaling by wnt#GO:0198738;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane protein complex#GO:0098796;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cell-cell junction#GO:0005911;anchoring junction#GO:0070161;plasma membrane protein complex#GO:0098797;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;extrinsic component of membrane#GO:0019898;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;adherens junction#GO:0005912;plasma membrane#GO:0005886 Cadherin signaling pathway#P00012>betacatenin#P00463;p53 pathway feedback loops 2#P04398>beta-catenin#P04670;Wnt signaling pathway#P00057>Beta-Catenin#P01432;Angiogenesis#P00005>beta catenin#P00187;Alzheimer disease-presenilin pathway#P00004>beta-catenin#P00156 HELRO|EnsemblGenome=HelroG181014|UniProtKB=T1FGJ1 T1FGJ1 20207940 PTHR10656:SF42 CELL FATE DETERMINING PROTEIN MAB21-RELATED CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED transferase#PC00220;nucleotidyltransferase#PC00174;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG162994|UniProtKB=T1ETI6 T1ETI6 20199886 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189935|UniProtKB=T1FRI0 T1FRI0 20211427 PTHR10182:SF3 CALCIUM-BINDING PROTEIN 39-RELATED PROTEIN MO25 protein kinase activator activity#GO:0030295;molecular function activator activity#GO:0140677;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234;kinase activator activity#GO:0019209 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 HELRO|EnsemblGenome=HelroG83989|UniProtKB=T1G5C8 T1G5C8 20216275 PTHR11347:SF102 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE PHOSPHODIESTERASE hydrolase activity, acting on ester bonds#GO:0016788;cyclic-nucleotide phosphodiesterase activity#GO:0004112;binding#GO:0005488;catalytic activity#GO:0003824;identical protein binding#GO:0042802;hydrolase activity#GO:0016787;protein binding#GO:0005515;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578 positive regulation of gene expression#GO:0010628;heterocycle catabolic process#GO:0046700;cyclic nucleotide metabolic process#GO:0009187;positive regulation of cellular metabolic process#GO:0031325;regulation of cellular component organization#GO:0051128;ribonucleotide catabolic process#GO:0009261;regulation of cAMP-mediated signaling#GO:0043949;regulation of intracellular signal transduction#GO:1902531;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;regulation of mitochondrion organization#GO:0010821;purine ribonucleotide catabolic process#GO:0009154;regulation of signal transduction#GO:0009966;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;positive regulation of biological process#GO:0048518;negative regulation of cell communication#GO:0010648;organic substance metabolic process#GO:0071704;purine nucleotide metabolic process#GO:0006163;nucleoside phosphate catabolic process#GO:1901292;carbohydrate derivative catabolic process#GO:1901136;regulation of organelle organization#GO:0033043;negative regulation of signaling#GO:0023057;cellular metabolic process#GO:0044237;nucleotide catabolic process#GO:0009166;cell communication#GO:0007154;cellular nitrogen compound metabolic process#GO:0034641;positive regulation of macromolecule metabolic process#GO:0010604;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;organophosphate catabolic process#GO:0046434;positive regulation of cellular process#GO:0048522;primary metabolic process#GO:0044238;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;negative regulation of signal transduction#GO:0009968;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;nucleotide metabolic process#GO:0009117;cAMP-mediated signaling#GO:0019933;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;small molecule metabolic process#GO:0044281;cellular aromatic compound metabolic process#GO:0006725;negative regulation of biological process#GO:0048519;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;organonitrogen compound catabolic process#GO:1901565;phosphorus metabolic process#GO:0006793;purine-containing compound catabolic process#GO:0072523;cellular nitrogen compound catabolic process#GO:0044270;phosphate-containing compound metabolic process#GO:0006796;positive regulation of biosynthetic process#GO:0009891;purine nucleotide catabolic process#GO:0006195;positive regulation of metabolic process#GO:0009893;organic cyclic compound metabolic process#GO:1901360;regulation of biosynthetic process#GO:0009889;positive regulation of macromolecule biosynthetic process#GO:0010557;catabolic process#GO:0009056;regulation of macromolecule biosynthetic process#GO:0010556;organic substance catabolic process#GO:1901575;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;heterocycle metabolic process#GO:0046483;regulation of cell communication#GO:0010646;cellular response to stimulus#GO:0051716;negative regulation of response to stimulus#GO:0048585;organonitrogen compound metabolic process#GO:1901564;cGMP-mediated signaling#GO:0019934;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;response to stimulus#GO:0050896;negative regulation of cAMP-mediated signaling#GO:0043951;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;cyclic-nucleotide-mediated signaling#GO:0019935;nucleobase-containing small molecule metabolic process#GO:0055086 bounding membrane of organelle#GO:0098588;synapse#GO:0045202;perinuclear region of cytoplasm#GO:0048471;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;mitochondrial matrix#GO:0005759;plasma membrane region#GO:0098590;membrane-enclosed lumen#GO:0031974;envelope#GO:0031975;mitochondrial membrane#GO:0031966;organelle lumen#GO:0043233;nucleus#GO:0005634;cell junction#GO:0030054;intracellular organelle lumen#GO:0070013;organelle inner membrane#GO:0019866;mitochondrion#GO:0005739;cell periphery#GO:0071944;membrane#GO:0016020;synaptic membrane#GO:0097060;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867;plasma membrane#GO:0005886 phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG62222|UniProtKB=T1FWX2 T1FWX2 20213320 PTHR12268:SF14 E3 UBIQUITIN-PROTEIN LIGASE KCMF1 DYSTROPHIN-1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG180766|UniProtKB=T1FG91 T1FG91 20207840 PTHR10627:SF31 SCP160 DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG108787|UniProtKB=T1EEM4 T1EEM4 20195026 PTHR11662:SF399 SOLUTE CARRIER FAMILY 17 FI19708P1-RELATED secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG183518|UniProtKB=T1FJS2 T1FJS2 20209071 PTHR21084:SF1 DENSE INCISORS DENSE INCISORS HELRO|EnsemblGenome=HelroG86883|UniProtKB=T1G6I8 T1G6I8 20216685 PTHR20863:SF28 ACYL CARRIER PROTEIN ACYL CARRIER PROTEIN, MITOCHONDRIAL small molecule binding#GO:0036094;binding#GO:0005488 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG165620|UniProtKB=T1EX32 T1EX32 20201132 PTHR24406:SF24 TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED IP01015P-RELATED nucleic acid binding#GO:0003676;protein-containing complex binding#GO:0044877;chromatin DNA binding#GO:0031490;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG116255|UniProtKB=T1EGD8 T1EGD8 20195640 PTHR24241:SF161 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;binding#GO:0005488;amide binding#GO:0033218;peptide binding#GO:0042277;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled peptide receptor activity#GO:0008528;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;cellular response to endogenous stimulus#GO:0071495;cellular response to chemical stimulus#GO:0070887;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to endogenous stimulus#GO:0009719;response to hormone#GO:0009725;cellular response to hormone stimulus#GO:0032870;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG160140|UniProtKB=T1EPV4 T1EPV4 20198604 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190776|UniProtKB=T1FSA4 T1FSA4 20211701 PTHR10857:SF102 COPINE C2 DOMAIN-CONTAINING PROTEIN lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;cellular process#GO:0009987;response to chemical#GO:0042221 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG75635|UniProtKB=T1G280 T1G280 20215178 PTHR24092:SF190 PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE PHOSPHOLIPID-TRANSPORTING ATPASE ATPase-coupled intramembrane lipid transporter activity#GO:0140326;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;lipid transporter activity#GO:0005319 organophosphate ester transport#GO:0015748;Golgi organization#GO:0007030;macromolecule localization#GO:0033036;membrane organization#GO:0061024;transport#GO:0006810;endomembrane system organization#GO:0010256;cellular component organization#GO:0016043;regulation of membrane lipid distribution#GO:0097035;phospholipid transport#GO:0015914;cellular process#GO:0009987;lipid transport#GO:0006869;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;organelle organization#GO:0006996;biological regulation#GO:0065007;lipid translocation#GO:0034204;lipid localization#GO:0010876;phospholipid translocation#GO:0045332 cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi apparatus subcompartment#GO:0098791;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG62108|UniProtKB=T1FWV9 T1FWV9 20213307 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG181213|UniProtKB=T1FGR2 T1FGR2 20208011 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193117|UniProtKB=T1FUN0 T1FUN0 20212526 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184015|UniProtKB=T1FKF4 T1FKF4 20209303 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG78206|UniProtKB=T1G395 T1G395 20215543 PTHR10357:SF179 ALPHA-AMYLASE FAMILY MEMBER NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 carbohydrate catabolic process#GO:0016052;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carbohydrate metabolic process#GO:0005975;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238;metabolic process#GO:0008152 amylase#PC00048;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG175784|UniProtKB=T1F9N5 T1F9N5 20205534 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163669|UniProtKB=T1EUC3 T1EUC3 20200173 PTHR46601:SF1 ULP_PROTEASE DOMAIN-CONTAINING PROTEIN ADF-H DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG108746|UniProtKB=T1EEM2 T1EEM2 20195024 PTHR11071:SF561 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;catalytic activity#GO:0003824;peptide binding#GO:0042277;amide binding#GO:0033218 macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein peptidyl-prolyl isomerization#GO:0000413;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG75552|UniProtKB=T1G263 T1G263 20215161 PTHR43655:SF8 ATP-DEPENDENT PROTEASE PARAPLEGIN mitochondrial protein processing#GO:0034982;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;peptidase complex#GO:1905368;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;mitochondrial protein-containing complex#GO:0098798 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG188468|UniProtKB=T1FQ09 T1FQ09 20210906 PTHR12327:SF0 ALPHA-TUBULIN N-ACETYLTRANSFERASE 1 ALPHA-TUBULIN N-ACETYLTRANSFERASE 1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;protein acylation#GO:0043543;protein metabolic process#GO:0019538;protein acetylation#GO:0006473;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG188900|UniProtKB=T1FQG4 T1FQG4 20211061 PTHR14398:SF0 RNA RECOGNITION RRM/RNP DOMAIN ZINC FINGER PROTEIN SWM nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG68226|UniProtKB=T1FZB8 T1FZB8 20214166 PTHR10155:SF32 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT LP02169P enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;phosphatidylinositol 3-kinase complex#GO:0005942;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;membrane#GO:0016020;transferase complex, transferring phosphorus-containing groups#GO:0061695;extrinsic component of membrane#GO:0019898 kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG176191|UniProtKB=T1FAA2 T1FAA2 20205751 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192968|UniProtKB=T1FUG8 T1FUG8 20212464 PTHR23033:SF14 BETA1,3-GALACTOSYLTRANSFERASE GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED galactosyltransferase activity#GO:0008378;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG158469|UniProtKB=T1EMU0 T1EMU0 20197890 PTHR39267:SF1 SURVIVAL MOTOR NEURON-LIKE PROTEIN 1 SURVIVAL MOTOR NEURON PROTEIN HELRO|EnsemblGenome=HelroG189760|UniProtKB=T1FRC5 T1FRC5 20211372 PTHR19861:SF0 WD40 REPEAT PROTEIN SWD2 WD REPEAT-CONTAINING PROTEIN 82 protein-containing complex binding#GO:0044877;binding#GO:0005488;chromatin binding#GO:0003682 membrane-enclosed lumen#GO:0031974;histone methyltransferase complex#GO:0035097;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;methyltransferase complex#GO:0034708;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;Set1C/COMPASS complex#GO:0048188;nuclear protein-containing complex#GO:0140513 methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG161095|UniProtKB=T1ER36 T1ER36 20199036 PTHR14796:SF3 NEURENSIN 1-RELATED NEURENSIN 1-LIKE-RELATED multicellular organismal process#GO:0032501;system development#GO:0048731;nervous system development#GO:0007399;anatomical structure development#GO:0048856;multicellular organism development#GO:0007275;developmental process#GO:0032502 somatodendritic compartment#GO:0036477;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;neuronal cell body#GO:0043025;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;neuron projection#GO:0043005;cell body#GO:0044297;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;transport vesicle#GO:0030133;cell projection#GO:0042995 HELRO|EnsemblGenome=HelroG189386|UniProtKB=T1FR06 T1FR06 20211253 PTHR10177:SF584 CYCLINS CYCLIN G protein kinase regulator activity#GO:0019887;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 regulation of protein kinase activity#GO:0045859;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;mitotic cell cycle phase transition#GO:0044772;regulation of nitrogen compound metabolic process#GO:0051171;cell cycle process#GO:0022402;regulation of catalytic activity#GO:0050790;cellular process#GO:0009987;cell cycle phase transition#GO:0044770;mitotic cell cycle process#GO:1903047;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;regulation of primary metabolic process#GO:0080090;mitotic cell cycle#GO:0000278;regulation of macromolecule metabolic process#GO:0060255;regulation of molecular function#GO:0065009;regulation of protein phosphorylation#GO:0001932;regulation of cellular process#GO:0050794;regulation of protein serine/threonine kinase activity#GO:0071900;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cyclin-dependent protein serine/threonine kinase activity#GO:0000079;regulation of kinase activity#GO:0043549;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622 kinase activator#PC00138 HELRO|EnsemblGenome=HelroG193034|UniProtKB=T1FUJ7 T1FUJ7 20212493 PTHR22765:SF416 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE GODZILLA transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG68111|UniProtKB=T1FZA4 T1FZA4 20214152 PTHR46061:SF3 THYROTROPIN-RELEASING HORMONE RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 Thyrotropin-releasing hormone receptor signaling pathway#P04394>TRH Receptor#P04580 HELRO|EnsemblGenome=HelroG112766|UniProtKB=T1EFM0 T1EFM0 20195372 PTHR45630:SF8 CATION-TRANSPORTING ATPASE-RELATED CATION-TRANSPORTING ATPASE transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;active monoatomic ion transmembrane transporter activity#GO:0022853;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation transmembrane transporter activity#GO:0008324 localization#GO:0051179;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG133020|UniProtKB=T1EI02 T1EI02 20196202 PTHR24392:SF56 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 510 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG173679|UniProtKB=T1F740 T1F740 20204639 PTHR21297:SF0 DNA-DIRECTED RNA POLYMERASE II DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB4 protein binding#GO:0005515;translation initiation factor binding#GO:0031369;binding#GO:0005488 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;transcription initiation at RNA polymerase II promoter#GO:0006367;mRNA 3'-end processing#GO:0031124;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;aromatic compound biosynthetic process#GO:0019438;protein-RNA complex organization#GO:0071826;transcription by RNA polymerase II#GO:0006366 membrane-enclosed lumen#GO:0031974;RNA polymerase II, core complex#GO:0005665;organelle lumen#GO:0043233;nucleus#GO:0005634;DNA-directed RNA polymerase complex#GO:0000428;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nucleoplasm#GO:0005654;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388;General transcription regulation#P00023>RNA Polymerase II#P00660 HELRO|EnsemblGenome=HelroG173090|UniProtKB=T1F6B8 T1F6B8 20204367 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG71773|UniProtKB=T1G0R4 T1G0R4 20214662 PTHR18945:SF784 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 1 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;localization#GO:0051179;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 membrane protein complex#GO:0098796;synapse#GO:0045202;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron projection#GO:0043005;transmembrane transporter complex#GO:1902495;cell projection#GO:0042995;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 Nicotinic acetylcholine receptor signaling pathway#P00044>beta#P01095;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HELRO|EnsemblGenome=HelroG173963|UniProtKB=T1F7F2 T1F7F2 20204751 PTHR47032:SF1 UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG157895|UniProtKB=T1EMH5 T1EMH5 20197775 PTHR21292:SF1 EXOCYST COMPLEX COMPONENT SEC6-RELATED EXOCYST COMPLEX COMPONENT 3 protein binding#GO:0005515;binding#GO:0005488;SNARE binding#GO:0000149 localization#GO:0051179;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;export from cell#GO:0140352;protein-containing complex localization#GO:0031503;secretion by cell#GO:0032940 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;vesicle tethering complex#GO:0099023;exocyst#GO:0000145;cell cortex#GO:0005938;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG83659|UniProtKB=T1G588 T1G588 20216235 PTHR24056:SF495 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 8-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Insulin/IGF pathway-protein kinase B signaling cascade#P00033>GSK-3#P00902;Cell cycle#P00013>Cdk4/6#P00479;PDGF signaling pathway#P00047>GSK3#P01153 HELRO|EnsemblGenome=HelroG181600|UniProtKB=T1FH56 T1FH56 20208155 PTHR22973:SF12 LD35087P LD35087P cytoplasm#GO:0005737;bounding membrane of organelle#GO:0098588;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG111841|UniProtKB=T1EFE9 T1EFE9 20195301 PTHR10454:SF210 CASPASE CASPASE-2 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG123056|UniProtKB=T1EGW7 T1EGW7 20195817 PTHR23279:SF36 DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED DEFECTIVE PROBOSCIS EXTENSION RESPONSE 9, ISOFORM A cellular component organization or biogenesis#GO:0071840;synapse organization#GO:0050808;cellular component organization#GO:0016043;cellular process#GO:0009987;cell junction organization#GO:0034330 cell leading edge#GO:0031252;neuron projection#GO:0043005;leading edge membrane#GO:0031256;plasma membrane region#GO:0098590;cell projection membrane#GO:0031253;cell projection#GO:0042995;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG186235|UniProtKB=T1FNU8 T1FNU8 20210495 PTHR12697:SF5 PBS LYASE HEAT-LIKE PROTEIN DEOXYHYPUSINE HYDROXYLASE oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 lyase#PC00144 HELRO|EnsemblGenome=HelroG142036|UniProtKB=T1EJ47 T1EJ47 20196597 PTHR24230:SF75 G-PROTEIN COUPLED RECEPTOR RELAXIN FAMILY PEPTIDE RECEPTOR 3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;neuropeptide signaling pathway#GO:0007218;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG133378|UniProtKB=T1EI06 T1EI06 20196206 PTHR24409:SF409 ZINC FINGER PROTEIN 142 C2H2-TYPE DOMAIN-CONTAINING PROTEIN C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG169999|UniProtKB=T1F2I6 T1F2I6 20203036 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG159559|UniProtKB=T1EP59 T1EP59 20198359 PTHR10682:SF10 POLY A POLYMERASE POLYNUCLEOTIDE ADENYLYLTRANSFERASE adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;mRNA polyadenylation#GO:0006378;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;mRNA 3'-end processing#GO:0031124;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mRNA processing#GO:0006397;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG105598|UniProtKB=T1EDW5 T1EDW5 20194767 PTHR12372:SF7 PECANEX PROTEIN PECANEX HELRO|EnsemblGenome=HelroG109820|UniProtKB=T1EEW6 T1EEW6 20195118 PTHR43157:SF31 PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG153295|UniProtKB=T1EL27 T1EL27 20197277 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG100335|UniProtKB=T1ECZ2 T1ECZ2 20194444 PTHR13504:SF34 FIDO DOMAIN-CONTAINING PROTEIN DDB_G0283145 PROTEIN ADENYLYLTRANSFERASE FICD HELRO|EnsemblGenome=HelroG172507|UniProtKB=T1F5F4 T1F5F4 20204053 PTHR13595:SF3 ARL6IP4 PROTEIN CXC DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171364|UniProtKB=T1F465 T1F465 20203614 PTHR16089:SF28 REST COREPRESSOR COREST PROTEIN-RELATED REST COREPRESSOR molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;protein-macromolecule adaptor activity#GO:0030674 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;histone deacetylase complex#GO:0000118;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG185072|UniProtKB=T1FMD0 T1FMD0 20209979 PTHR45698:SF1 TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG165024|UniProtKB=T1EW57 T1EW57 20200807 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG70561|UniProtKB=T1G086 T1G086 20214484 PTHR15079:SF3 MYD88 MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88 scaffold/adaptor protein#PC00226 Toll pathway-drosophila#P06217>MyD88#P06346;Toll receptor signaling pathway#P00054>MyD88#P01377 HELRO|EnsemblGenome=HelroG117164|UniProtKB=T1EGK7 T1EGK7 20195707 PTHR11920:SF501 GUANYLYL CYCLASE GUANYLATE CYCLASE 32E adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG129502|UniProtKB=T1EHR6 T1EHR6 20196116 PTHR24093:SF369 CATION TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE calcium ion transmembrane transporter activity#GO:0015085;inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;P-type ion transporter activity#GO:0015662;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075 intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG66482|UniProtKB=T1FYL9 T1FYL9 20213917 PTHR11827:SF73 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS KAZACHOC, ISOFORM G inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium ion transmembrane transporter activity#GO:0015079;symporter activity#GO:0015293;chloride transmembrane transporter activity#GO:0015108;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 inorganic ion homeostasis#GO:0098771;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;inorganic anion transmembrane transport#GO:0098661;import across plasma membrane#GO:0098739;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;inorganic anion transport#GO:0015698;potassium ion transport#GO:0006813;regulation of anatomical structure size#GO:0090066;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;monoatomic anion transmembrane transport#GO:0098656;chloride transport#GO:0006821;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;cellular component organization#GO:0016043;cellular process#GO:0009987;chemical homeostasis#GO:0048878;regulation of cellular component size#GO:0032535;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;regulation of cell size#GO:0008361;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;potassium ion import across plasma membrane#GO:1990573 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG132449|UniProtKB=T1EHY6 T1EHY6 20196186 PTHR13370:SF3 RNA METHYLASE-RELATED TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG methyltransferase activity#GO:0008168;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG126196|UniProtKB=T1EH85 T1EH85 20195935 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED single-stranded RNA binding#GO:0003727;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;poly(A) binding#GO:0008143;binding#GO:0005488;organic cyclic compound binding#GO:0097159 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG185960|UniProtKB=T1FNH7 T1FNH7 20210374 PTHR24250:SF50 CHYMOTRYPSIN-RELATED PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG67914|UniProtKB=T1FZ76 T1FZ76 20214124 PTHR12968:SF2 B9 DOMAIN-CONTAINING B9 DOMAIN-CONTAINING PROTEIN 2 organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cilium#GO:0005929;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;ciliary transition zone#GO:0035869 structural protein#PC00211 HELRO|EnsemblGenome=HelroG174303|UniProtKB=T1F7Z1 T1F7Z1 20204940 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191241|UniProtKB=T1FSS3 T1FSS3 20211870 PTHR12081:SF18 TRANSCRIPTION FACTOR E2F TRANSCRIPTION FACTOR E2F2-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 p53 pathway feedback loops 2#P04398>E2F-1#P04652;p53 pathway#P00059>E2F-1#P04627;Cell cycle#P00013>E2F#P00488 HELRO|EnsemblGenome=HelroG85515|UniProtKB=T1G5Y3 T1G5Y3 20216480 PTHR12468:SF2 GPI MANNOSYLTRANSFERASE 2 GPI MANNOSYLTRANSFERASE 2 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG167644|UniProtKB=T1EZL8 T1EZL8 20202018 PTHR24410:SF23 HL07962P-RELATED BTB DOMAIN-CONTAINING PROTEIN-RELATED defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG98278|UniProtKB=T1G9L7 T1G9L7 20217763 PTHR24412:SF451 KELCH PROTEIN KELCH-LIKE PROTEIN 20 scaffold/adaptor protein#PC00226 Apoptosis signaling pathway#P00006>Smac/Diablo#P00309 HELRO|EnsemblGenome=HelroG78116|UniProtKB=T1G382 T1G382 20215530 PTHR12982:SF0 PHOSPHATIDYLINOSITOL GLYCAN, CLASS C PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C membrane protein complex#GO:0098796;endoplasmic reticulum protein-containing complex#GO:0140534;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG187620|UniProtKB=T1FPB2 T1FPB2 20210659 PTHR11537:SF254 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG166960|UniProtKB=T1EYT2 T1EYT2 20201732 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG111405|UniProtKB=T1EFA9 T1EFA9 20195261 PTHR19961:SF18 FIMBRIN/PLASTIN FI19014P1 cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament bundle assembly#GO:0051017;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;actin filament bundle organization#GO:0061572;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;actin filament bundle#GO:0032432;actin cytoskeleton#GO:0015629;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;actin filament#GO:0005884;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG99479|UniProtKB=T1G9T0 T1G9T0 20217826 PTHR14463:SF5 LIPASE MATURATION FACTOR LIPASE MATURATION FACTOR 2 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG192199|UniProtKB=T1FTP3 T1FTP3 20212190 PTHR31056:SF1 TRANSMEMBRANE PROTEIN 179B TRANSMEMBRANE PROTEIN 179B HELRO|EnsemblGenome=HelroG191164|UniProtKB=T1FSP2 T1FSP2 20211839 PTHR24416:SF349 TYROSINE-PROTEIN KINASE RECEPTOR TYROSINE-PROTEIN KINASE RYK signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;regulation of cellular component organization#GO:0051128;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;regulation of plasma membrane bounded cell projection organization#GO:0120035;cell communication#GO:0007154;cellular process#GO:0009987;regulation of neuron projection development#GO:0010975;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;regulation of cell projection organization#GO:0031344;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG175152|UniProtKB=T1F8X4 T1F8X4 20205273 PTHR15505:SF4 RIIA DOMAIN-CONTAINING PROTEIN 1 RIIA DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG114417|UniProtKB=T1EG15 T1EG15 20195517 PTHR11822:SF21 NADP-SPECIFIC ISOCITRATE DEHYDROGENASE ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG183467|UniProtKB=T1FJQ2 T1FJQ2 20209051 PTHR14155:SF627 RING FINGER DOMAIN-CONTAINING OS06G0192800 PROTEIN ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG83286|UniProtKB=T1G535 T1G535 20216183 PTHR47979:SF53 DRAB11-RELATED FI07418P GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;transport#GO:0006810 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG172251|UniProtKB=T1F560 T1F560 20203959 PTHR46557:SF1 SERINE/THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10 phosphatase binding#GO:0019902;enzyme binding#GO:0019899;protein binding#GO:0005515;protein phosphatase binding#GO:0019903;binding#GO:0005488 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;protein-DNA complex#GO:0032993;chromosome#GO:0005694;chromatin#GO:0000785;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG93352|UniProtKB=T1G8V3 T1G8V3 20217500 PTHR45961:SF6 IP21249P IP21249P Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG183252|UniProtKB=T1FJD6 T1FJD6 20208935 PTHR24410:SF23 HL07962P-RELATED BTB DOMAIN-CONTAINING PROTEIN-RELATED defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG166534|UniProtKB=T1EY80 T1EY80 20201530 PTHR28634:SF1 ZINC FINGER B-BOX DOMAIN-CONTAINING PROTEIN 1 ZINC FINGER B-BOX DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG188814|UniProtKB=T1FQE2 T1FQE2 20211039 PTHR15672:SF8 CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN PROTEIN ENCORE HELRO|EnsemblGenome=HelroG126208|UniProtKB=T1EH86 T1EH86 20195936 PTHR45942:SF1 PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1 PROTEIN PHOSPHATASE 3 REGULATORY SUBUNIT B, ALPHA phosphatase binding#GO:0019902;phosphatase regulator activity#GO:0019208;binding#GO:0005488;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888;protein binding#GO:0005515;enzyme binding#GO:0019899;enzyme regulator activity#GO:0030234 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;calcium-mediated signaling#GO:0019722;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;calcineurin-mediated signaling#GO:0097720;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;cell communication#GO:0007154;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;dephosphorylation#GO:0016311;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 protein serine/threonine phosphatase complex#GO:0008287;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;catalytic complex#GO:1902494 Wnt signaling pathway#P00057>Calcineurin#P01446 HELRO|EnsemblGenome=HelroG178702|UniProtKB=T1FDL5 T1FDL5 20206914 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG78040|UniProtKB=T1G371 T1G371 20215519 PTHR23129:SF0 ACYL-COENZYME A DIPHOSPHATASE FITM2 ACYL-COENZYME A DIPHOSPHATASE FITM2 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;macromolecule localization#GO:0033036;organophosphate biosynthetic process#GO:0090407;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;maintenance of location#GO:0051235;organophosphate metabolic process#GO:0019637;lipid localization#GO:0010876;lipid storage#GO:0019915;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG192963|UniProtKB=T1FUG6 T1FUG6 20212462 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG135982|UniProtKB=T1EIB3 T1EIB3 20196313 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG184310|UniProtKB=T1FKY7 T1FKY7 20209486 PTHR45735:SF2 CLEAVAGE STIMULATION FACTOR SUBUNIT 2 CLEAVAGE STIMULATION FACTOR SUBUNIT 2 nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;mRNA cleavage factor complex#GO:0005849;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG176639|UniProtKB=T1FAR3 T1FAR3 20205912 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG71249|UniProtKB=T1G0I4 T1G0I4 20214582 PTHR11616:SF321 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;organic acid:sodium symporter activity#GO:0005343;organic acid transmembrane transporter activity#GO:0005342;symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;organic anion transmembrane transporter activity#GO:0008514;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;amino acid:sodium symporter activity#GO:0005283;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;amino acid transmembrane transporter activity#GO:0015171;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;organic anion transport#GO:0015711;amino acid transport#GO:0006865;organic acid transport#GO:0015849;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;nitrogen compound transport#GO:0071705;carboxylic acid transport#GO:0046942;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;amino acid import across plasma membrane#GO:0089718;carboxylic acid transmembrane transport#GO:1905039;localization#GO:0051179;organic substance transport#GO:0071702;import across plasma membrane#GO:0098739;amino acid transmembrane transport#GO:0003333;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transport#GO:0006812;organic acid transmembrane transport#GO:1903825;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>CHT1#P01084 HELRO|EnsemblGenome=HelroG72863|UniProtKB=T1G164 T1G164 20214812 PTHR45620:SF1 PDF RECEPTOR-LIKE PROTEIN-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;peptide hormone binding#GO:0017046;binding#GO:0005488;peptide binding#GO:0042277;amide binding#GO:0033218;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled peptide receptor activity#GO:0008528;hormone binding#GO:0042562;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG62111|UniProtKB=T1FWW0 T1FWW0 20213308 PTHR23003:SF51 RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN SERINE-ARGININE PROTEIN 55 nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG71732|UniProtKB=T1G0Q8 T1G0Q8 20214656 PTHR11202:SF3 SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER SPROUTY-RELATED PROTEIN WITH EVH-1 DOMAIN, ISOFORM C enzyme binding#GO:0019899;protein binding#GO:0005515;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900 regulation of cell communication#GO:0010646;regulation of MAPK cascade#GO:0043408;negative regulation of biological process#GO:0048519;negative regulation of response to stimulus#GO:0048585;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;negative regulation of MAPK cascade#GO:0043409;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of cellular process#GO:0048523;negative regulation of cell communication#GO:0010648 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG88016|UniProtKB=T1G6X4 T1G6X4 20216821 PTHR45864:SF2 SLINGSHOT PROTEIN PHOSPHATASE HOMOLOG PROTEIN PHOSPHATASE SLINGSHOT protein phosphatase#PC00195;protein modifying enzyme#PC00260 Cytoskeletal regulation by Rho GTPase#P00016>Slingshot#P00509 HELRO|EnsemblGenome=HelroG87629|UniProtKB=T1G6T3 T1G6T3 20216780 PTHR23506:SF23 GH10249P GH10249P secondary carrier transporter#PC00258;transporter#PC00227 Adrenaline and noradrenaline biosynthesis#P00001>VAT1#P00071;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>VAChT#P01078;5HT3 type receptor mediated signaling pathway#P04375>5HT vesicular transporter#P04424;5HT2 type receptor mediated signaling pathway#P04374>5HT vesicular transporter#P04418;Nicotinic acetylcholine receptor signaling pathway#P00044>VAChT#P01089;5HT4 type receptor mediated signaling pathway#P04376>5HT vesicular transporter#P04432;5HT1 type receptor mediated signaling pathway#P04373>5HT vesicular transporter#P04410 HELRO|EnsemblGenome=HelroG183207|UniProtKB=T1FJB2 T1FJB2 20208911 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED FMRFAMIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG87714|UniProtKB=T1G6U7 T1G6U7 20216794 PTHR23147:SF22 SERINE/ARGININE RICH SPLICING FACTOR SERINE_ARGININE-RICH SPLICING FACTOR 2 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;nuclear speck#GO:0016607;organelle#GO:0043226;nuclear body#GO:0016604;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG80550|UniProtKB=T1G419 T1G419 20215817 PTHR46306:SF1 BTB/POZ DOMAIN-CONTAINING PROTEIN 9 BTB_POZ DOMAIN-CONTAINING PROTEIN 9 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG156363|UniProtKB=T1ELU3 T1ELU3 20197543 PTHR13568:SF6 FAM11A, B PROTEIN TRANSMEMBRANE PROTEIN 185A HELRO|EnsemblGenome=HelroG166542|UniProtKB=T1EY81 T1EY81 20201531 PTHR11668:SF300 SERINE/THREONINE PROTEIN PHOSPHATASE SERINE_THREONINE-PROTEIN PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 Nicotine pharmacodynamics pathway#P06587>PPP1CA#P06602;Dopamine receptor mediated signaling pathway#P05912>Protein Phosphatase-1#P05969 HELRO|EnsemblGenome=HelroG66967|UniProtKB=T1FYU1 T1FYU1 20213989 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-LIKE 1 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;localization#GO:0051179;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 membrane protein complex#GO:0098796;synapse#GO:0045202;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron projection#GO:0043005;transmembrane transporter complex#GO:1902495;cell projection#GO:0042995;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HELRO|EnsemblGenome=HelroG153385|UniProtKB=T1EL62 T1EL62 20197319 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176269|UniProtKB=T1FAC6 T1FAC6 20205775 PTHR24039:SF52 FIBRILLIN-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG166344|UniProtKB=T1EY15 T1EY15 20201465 PTHR24134:SF9 ANKYRIN REPEAT-CONTAINING PROTEIN DDB_G0279043 ANKYRIN REPEAT AND SOCS BOX PROTEIN 8 HELRO|EnsemblGenome=HelroG101612|UniProtKB=T1ED58 T1ED58 20194510 PTHR11999:SF70 GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE MIP05841P decarboxylase#PC00089 5-Hydroxytryptamine biosynthesis#P04371>Aromatic L-amino acid decarboxylase#P04400;Dopamine receptor mediated signaling pathway#P05912>DOPA decarb.#P05961;Adrenaline and noradrenaline biosynthesis#P00001>DOPA decarb.#P00066 HELRO|EnsemblGenome=HelroG85704|UniProtKB=T1G620 T1G620 20216517 PTHR24045:SF0 FAMILY NOT NAMED N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNITS ALPHA_BETA HELRO|EnsemblGenome=HelroG145609|UniProtKB=T1EJL3 T1EJL3 20196763 PTHR24390:SF222 ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG166711|UniProtKB=T1EYE7 T1EYE7 20201597 PTHR46830:SF1 TRANSFERASE, PUTATIVE-RELATED ALPHA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG72925|UniProtKB=T1G173 T1G173 20214821 PTHR24248:SF66 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR OCTOPAMINE RECEPTOR BETA-3R signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;regulation of cell communication#GO:0010646;cellular response to stimulus#GO:0051716;regulation of MAPK cascade#GO:0043408;signal transduction#GO:0007165;positive regulation of signal transduction#GO:0009967;regulation of signaling#GO:0023051;cell communication#GO:0007154;cellular process#GO:0009987;regulation of intracellular signal transduction#GO:1902531;positive regulation of MAPK cascade#GO:0043410;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;positive regulation of response to stimulus#GO:0048584;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;positive regulation of cell communication#GO:0010647;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG167614|UniProtKB=T1EZK3 T1EZK3 20202003 PTHR32026:SF10 METHYLTRANSFERASE-LIKE PROTEIN 24 METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG75829|UniProtKB=T1G2A8 T1G2A8 20215206 PTHR43329:SF141 EPOXIDE HYDROLASE AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED hydrolase activity#GO:0016787;catalytic activity#GO:0003824 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG116792|UniProtKB=T1EGH9 T1EGH9 20195681 PTHR12587:SF14 LAR INTERACTING PROTEIN LIP -RELATED PROTEIN AT31531P cellular component organization or biogenesis#GO:0071840;synapse organization#GO:0050808;cellular component organization#GO:0016043;cellular process#GO:0009987;cell junction organization#GO:0034330;neuromuscular junction development#GO:0007528 cell junction#GO:0030054;presynapse#GO:0098793;synapse#GO:0045202;cellular anatomical entity#GO:0110165;presynaptic active zone#GO:0048786 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG187454|UniProtKB=T1FP99 T1FP99 20210646 PTHR18937:SF12 STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 cellular component organization or biogenesis#GO:0071840;sister chromatid cohesion#GO:0007062;organelle organization#GO:0006996;chromosome organization#GO:0051276;cell cycle process#GO:0022402;cell cycle#GO:0007049;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;cohesin complex#GO:0008278;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG160141|UniProtKB=T1EPV5 T1EPV5 20198605 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191436|UniProtKB=T1FSZ4 T1FSZ4 20211941 PTHR45702:SF2 ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER KUZBANIAN, ISOFORM A hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 membrane protein proteolysis#GO:0033619;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;membrane protein ectodomain proteolysis#GO:0006509;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-amyloid secretase pathway#P00003>ADAM10#P00108 HELRO|EnsemblGenome=HelroG186863|UniProtKB=T1FP43 T1FP43 20210590 PTHR11820:SF7 ACYLPYRUVASE ACYLPYRUVASE FAHD1, MITOCHONDRIAL hydrolase activity#GO:0016787;catalytic activity#GO:0003824 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG116230|UniProtKB=T1EGD6 T1EGD6 20195638 PTHR13096:SF8 MINA53 MYC INDUCED NUCLEAR ANTIGEN RIBOSOMAL OXYGENASE 1 HELRO|EnsemblGenome=HelroG87671|UniProtKB=T1G6U0 T1G6U0 20216787 PTHR46257:SF3 TYROSINE-PROTEIN PHOSPHATASE CORKSCREW TYROSINE-PROTEIN PHOSPHATASE CORKSCREW hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;protein binding#GO:0005515;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;peptidyl-tyrosine dephosphorylation#GO:0035335;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;developmental process#GO:0032502;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;cell communication#GO:0007154;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cell differentiation#GO:0030154;mitotic cell cycle#GO:0000278;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;dephosphorylation#GO:0016311;biological regulation#GO:0065007;cell cycle#GO:0007049;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 FGF signaling pathway#P00021>SHP2#P00647;Interferon-gamma signaling pathway#P00035>PTP#P00960 HELRO|EnsemblGenome=HelroG184997|UniProtKB=T1FM90 T1FM90 20209939 PTHR12931:SF15 UBIQUITIN THIOLESTERASE PROTEIN OTUB UBIQUITIN THIOESTERASE OTUBAIN-LIKE cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;ubiquitin-like protein binding#GO:0032182;binding#GO:0005488;catalytic activity#GO:0003824;ubiquitin binding#GO:0043130;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;protein binding#GO:0005515;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;protein K48-linked deubiquitination#GO:0071108;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG171770|UniProtKB=T1F4N0 T1F4N0 20203779 PTHR47027:SF20 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN HELRO|EnsemblGenome=HelroG188530|UniProtKB=T1FQ35 T1FQ35 20210932 PTHR46513:SF13 VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG176024|UniProtKB=T1FA14 T1FA14 20205663 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG158893|UniProtKB=T1END8 T1END8 20198088 PTHR19303:SF71 TRANSPOSON ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG105121|UniProtKB=T1EDR0 T1EDR0 20194712 PTHR24292:SF54 CYTOCHROME P450 CYP9F3-RELATED oxygenase#PC00177 HELRO|EnsemblGenome=HelroG174010|UniProtKB=T1F7H1 T1F7H1 20204770 PTHR11819:SF195 SOLUTE CARRIER FAMILY 5 SODIUM_GLUCOSE COTRANSPORTER 4 inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;carbohydrate transmembrane transporter activity#GO:0015144;symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;sugar transmembrane transporter activity#GO:0051119;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;monoatomic ion transmembrane transporter activity#GO:0015075;inorganic cation transmembrane transporter activity#GO:0022890;solute:monoatomic cation symporter activity#GO:0015294 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG80632|UniProtKB=T1G431 T1G431 20215829 PTHR43201:SF5 ACYL-COA SYNTHETASE MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL ligase activity#GO:0016874;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 lipid metabolic process#GO:0006629;oxoacid metabolic process#GO:0043436;fatty acid metabolic process#GO:0006631;cellular metabolic process#GO:0044237;cellular process#GO:0009987;cellular lipid metabolic process#GO:0044255;organic acid metabolic process#GO:0006082;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ligase#PC00142;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG139423|UniProtKB=T1EIY6 T1EIY6 20196536 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG183850|UniProtKB=T1FK96 T1FK96 20209245 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG181731|UniProtKB=T1FH96 T1FH96 20208195 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG175183|UniProtKB=T1F8Z1 T1F8Z1 20205290 PTHR23159:SF31 CENTROSOMAL PROTEIN 2 CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG176262|UniProtKB=T1FAC4 T1FAC4 20205773 PTHR19303:SF71 TRANSPOSON ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG179131|UniProtKB=T1FE78 T1FE78 20207127 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189594|UniProtKB=T1FR66 T1FR66 20211313 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG111117|UniProtKB=T1EF84 T1EF84 20195236 PTHR12616:SF8 VACUOLAR PROTEIN SORTING VPS41 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG vesicle fusion#GO:0006906;cellular localization#GO:0051641;macromolecule localization#GO:0033036;protein targeting to vacuole#GO:0006623;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;nitrogen compound transport#GO:0071705;establishment of protein localization#GO:0045184;organic substance transport#GO:0071702;establishment of localization#GO:0051234;vesicle organization#GO:0016050;protein localization to organelle#GO:0033365;organelle fusion#GO:0048284;establishment of protein localization to vacuole#GO:0072666;vacuolar transport#GO:0007034;protein localization to vacuole#GO:0072665;protein targeting#GO:0006605;establishment of protein localization to organelle#GO:0072594;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;membrane fusion#GO:0061025;cellular macromolecule localization#GO:0070727;organelle organization#GO:0006996;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle tethering complex#GO:0099023;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;late endosome#GO:0005770 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG178457|UniProtKB=T1FD68 T1FD68 20206767 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED BRCT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG114833|UniProtKB=T1EG47 T1EG47 20195549 PTHR11347:SF179 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 3',5'-CYCLIC PHOSPHODIESTERASE PDE-3-RELATED hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric diester hydrolase activity#GO:0008081;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;cAMP-mediated signaling#GO:0019933;signaling#GO:0023052;cyclic-nucleotide-mediated signaling#GO:0019935 phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG180190|UniProtKB=T1FFK3 T1FFK3 20207602 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG182860|UniProtKB=T1FIV8 T1FIV8 20208757 PTHR23121:SF9 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 transmembrane transporter activity#GO:0022857;sugar transmembrane transporter activity#GO:0051119;transporter activity#GO:0005215;carbohydrate transmembrane transporter activity#GO:0015144 transporter#PC00227 HELRO|EnsemblGenome=HelroG132401|UniProtKB=T1EHY4 T1EHY4 20196184 PTHR13225:SF3 MISEXPRESSION SUPPRESSOR OF RAS 6 UPF0489 PROTEIN C5ORF22 HELRO|EnsemblGenome=HelroG185741|UniProtKB=T1FN81 T1FN81 20210279 PTHR46283:SF2 E3 UBIQUITIN-PROTEIN LIGASE MARCH5 AT07234P-RELATED transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;regulation of anatomical structure morphogenesis#GO:0022603;macromolecule metabolic process#GO:0043170;regulation of organelle organization#GO:0033043;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;regulation of cellular component organization#GO:0051128;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of mitochondrion organization#GO:0010821;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 envelope#GO:0031975;bounding membrane of organelle#GO:0098588;mitochondrial membrane#GO:0031966;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG156571|UniProtKB=T1ELY5 T1ELY5 20197585 PTHR24351:SF234 RIBOSOMAL PROTEIN S6 KINASE SERINE_THREONINE-PROTEIN KINASE YPK2_YKR2 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG187844|UniProtKB=T1FPF2 T1FPF2 20210699 PTHR24345:SF91 SERINE/THREONINE-PROTEIN KINASE PLK SERINE_THREONINE-PROTEIN KINASE PLK4 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG66878|UniProtKB=T1FYS3 T1FYS3 20213971 PTHR47046:SF1 SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 1, MITOCHONDRIAL SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 1, MITOCHONDRIAL cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrial respiratory chain complex II assembly#GO:0034553;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;mitochondrion organization#GO:0007005;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG89573|UniProtKB=T1G7E4 T1G7E4 20216991 PTHR48012:SF18 STERILE20-LIKE KINASE, ISOFORM B-RELATED HAPPYHOUR, ISOFORM A transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Apoptosis signaling pathway#P00006>GCKR#P00311;Apoptosis signaling pathway#P00006>GCK#P00268 HELRO|EnsemblGenome=HelroG65082|UniProtKB=T1FY32 T1FY32 20213730 PTHR44269:SF2 DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7-RELATED DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG193009|UniProtKB=T1FUI4 T1FUI4 20212480 PTHR24028:SF339 CADHERIN-87A CADHERIN DOMAIN-CONTAINING PROTEIN cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG161006|UniProtKB=T1ER00 T1ER00 20199000 PTHR23025:SF3 TRIACYLGLYCEROL LIPASE HORMONE-SENSITIVE LIPASE hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824;triglyceride lipase activity#GO:0004806 lipid metabolic process#GO:0006629;triglyceride metabolic process#GO:0006641;neutral lipid catabolic process#GO:0046461;cellular metabolic process#GO:0044237;glycerolipid catabolic process#GO:0046503;triglyceride catabolic process#GO:0019433;lipid catabolic process#GO:0016042;cellular process#GO:0009987;acylglycerol metabolic process#GO:0006639;primary metabolic process#GO:0044238;acylglycerol catabolic process#GO:0046464;neutral lipid metabolic process#GO:0006638;glycerolipid metabolic process#GO:0046486;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 lipase#PC00143 Triacylglycerol metabolism#P02782>Triacylglycerol lipase#P03205 HELRO|EnsemblGenome=HelroG172591|UniProtKB=T1F5K5 T1F5K5 20204104 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG107343|UniProtKB=T1EE97 T1EE97 20194899 PTHR10653:SF0 F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 negative regulation of protein polymerization#GO:0032272;negative regulation of protein depolymerization#GO:1901880;negative regulation of biological process#GO:0048519;negative regulation of actin filament depolymerization#GO:0030835;regulation of cellular component organization#GO:0051128;regulation of actin polymerization or depolymerization#GO:0008064;regulation of biological process#GO:0050789;regulation of cytoskeleton organization#GO:0051493;actin filament-based process#GO:0030029;regulation of protein-containing complex assembly#GO:0043254;regulation of biological quality#GO:0065008;regulation of cellular component biogenesis#GO:0044087;negative regulation of organelle organization#GO:0010639;negative regulation of protein-containing complex disassembly#GO:0043242;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;barbed-end actin filament capping#GO:0051016;regulation of actin filament-based process#GO:0032970;negative regulation of cellular component organization#GO:0051129;regulation of protein polymerization#GO:0032271;negative regulation of cellular process#GO:0048523;regulation of anatomical structure size#GO:0090066;regulation of actin filament length#GO:0030832;regulation of organelle organization#GO:0033043;regulation of actin filament organization#GO:0110053;regulation of protein-containing complex disassembly#GO:0043244;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of actin filament polymerization#GO:0030833;regulation of cellular component size#GO:0032535;negative regulation of supramolecular fiber organization#GO:1902904;regulation of supramolecular fiber organization#GO:1902903;cellular component organization or biogenesis#GO:0071840;regulation of protein depolymerization#GO:1901879;regulation of actin filament depolymerization#GO:0030834;regulation of cellular process#GO:0050794;organelle organization#GO:0006996;negative regulation of actin filament polymerization#GO:0030837;biological regulation#GO:0065007;negative regulation of protein-containing complex assembly#GO:0031333;actin cytoskeleton organization#GO:0030036;negative regulation of cytoskeleton organization#GO:0051494 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;cell cortex#GO:0005938;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG171218|UniProtKB=T1F3Y5 T1F3Y5 20203534 PTHR10339:SF25 ADP-RIBOSYLTRANSFERASE SECRETED EXOENZYME S transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG160526|UniProtKB=T1EQC9 T1EQC9 20198779 PTHR13217:SF11 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 5 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052;Rho protein signal transduction#GO:0007266 HELRO|EnsemblGenome=HelroG156242|UniProtKB=T1ELT3 T1ELT3 20197533 PTHR11886:SF2 DYNEIN LIGHT CHAIN DYNEIN AXONEMAL LIGHT CHAIN 4 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Dynein complex#P00774 HELRO|EnsemblGenome=HelroG188683|UniProtKB=T1FQ91 T1FQ91 20210988 PTHR10288:SF338 KH DOMAIN CONTAINING RNA BINDING PROTEIN IGF-II MRNA-BINDING PROTEIN, ISOFORM L nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159;mRNA 3'-UTR binding#GO:0003730 developmental process#GO:0032502;multicellular organism development#GO:0007275;nervous system development#GO:0007399;regulation of biological process#GO:0050789;system development#GO:0048731;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG156780|UniProtKB=T1EM10 T1EM10 20197610 PTHR10061:SF0 S-FORMYLGLUTATHIONE HYDROLASE S-FORMYLGLUTATHIONE HYDROLASE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;thiolester hydrolase activity#GO:0016790 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG161003|UniProtKB=T1EQZ8 T1EQZ8 20198998 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194645|UniProtKB=T1FW99 T1FW99 20213095 PTHR22922:SF19 GPI-ANCHORED PROTEIN P137 CAPRIN HOMOLOG nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG71177|UniProtKB=T1G0H5 T1G0H5 20214573 PTHR10037:SF288 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM SODIUM CHANNEL PROTEIN PARA monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;sodium channel activity#GO:0005272;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;inorganic cation transmembrane transporter activity#GO:0022890 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;membrane depolarization#GO:0051899;transport#GO:0006810;regulation of membrane potential#GO:0042391;system process#GO:0003008;action potential#GO:0001508;nervous system process#GO:0050877;cell communication#GO:0007154;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;sodium ion transport#GO:0006814;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;multicellular organismal process#GO:0032501;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 membrane protein complex#GO:0098796;sodium channel complex#GO:0034706;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG66433|UniProtKB=T1FYL2 T1FYL2 20213910 PTHR10983:SF24 1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED 1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 3, ISOFORM E-RELATED acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;O-acyltransferase activity#GO:0008374 cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG163542|UniProtKB=T1EU65 T1EU65 20200115 PTHR20873:SF0 L-SERYL-TRNA(SEC) KINASE L-SERYL-TRNA(SEC) KINASE tRNA binding#GO:0000049;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;transferase activity#GO:0016740;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 HELRO|EnsemblGenome=HelroG180211|UniProtKB=T1FFK7 T1FFK7 20207606 PTHR43968:SF6 FAMILY NOT NAMED GLUTATHIONE S-TRANSFERASE OMEGA cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG186069|UniProtKB=T1FNM5 T1FNM5 20210422 PTHR43842:SF2 PROPIONYL-COA CARBOXYLASE BETA CHAIN PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL ligase activity#GO:0016874;catalytic activity#GO:0003824 metabolite interconversion enzyme#PC00262;ligase#PC00142 Methylmalonyl pathway#P02755>Propionyl-CoA carboxylase#P03033;Succinate to proprionate conversion#P02777>Methylmalonyl-CoA decarboxylase#P03163 HELRO|EnsemblGenome=HelroG108482|UniProtKB=T1EEJ5 T1EEJ5 20194997 PTHR11614:SF87 PHOSPHOLIPASE-RELATED MONOGLYCERIDE LIPASE hydrolase activity#GO:0016787;lipase activity#GO:0016298;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 cellular anatomical entity#GO:0110165;membrane#GO:0016020 phospholipase#PC00186;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG77859|UniProtKB=T1G348 T1G348 20215496 PTHR10807:SF109 MYOTUBULARIN-RELATED SET DOMAIN BINDING FACTOR, ISOFORM A nucleoside-triphosphatase regulator activity#GO:0060589;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;GTPase regulator activity#GO:0030695;catalytic activity#GO:0003824;molecular function regulator activity#GO:0098772;hydrolase activity#GO:0016787;enzyme regulator activity#GO:0030234;phosphoric ester hydrolase activity#GO:0042578;guanyl-nucleotide exchange factor activity#GO:0005085 phospholipid dephosphorylation#GO:0046839;lipid metabolic process#GO:0006629;phosphatidylinositol dephosphorylation#GO:0046856;cellular metabolic process#GO:0044237;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;lipid modification#GO:0030258;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;dephosphorylation#GO:0016311;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG116074|UniProtKB=T1EGC7 T1EGC7 20195629 PTHR10177:SF593 CYCLINS G2_MITOTIC-SPECIFIC CYCLIN-A protein kinase regulator activity#GO:0019887;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 regulation of protein kinase activity#GO:0045859;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;mitotic cell cycle phase transition#GO:0044772;regulation of nitrogen compound metabolic process#GO:0051171;cell cycle process#GO:0022402;regulation of catalytic activity#GO:0050790;cellular process#GO:0009987;cell cycle phase transition#GO:0044770;mitotic cell cycle process#GO:1903047;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;regulation of primary metabolic process#GO:0080090;mitotic cell cycle#GO:0000278;regulation of macromolecule metabolic process#GO:0060255;regulation of molecular function#GO:0065009;regulation of protein phosphorylation#GO:0001932;regulation of cellular process#GO:0050794;regulation of protein serine/threonine kinase activity#GO:0071900;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cyclin-dependent protein serine/threonine kinase activity#GO:0000079;regulation of kinase activity#GO:0043549;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622 kinase activator#PC00138 HELRO|EnsemblGenome=HelroG108808|UniProtKB=T1EEM7 T1EEM7 20195029 PTHR15608:SF0 SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2 HIV TAT-SPECIFIC FACTOR 1 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;protein-containing complex#GO:0032991;small nuclear ribonucleoprotein complex#GO:0030532;U2 snRNP#GO:0005686;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG182601|UniProtKB=T1FIG2 T1FIG2 20208611 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG181593|UniProtKB=T1FH52 T1FH52 20208151 PTHR21580:SF28 SHIPPO-1-RELATED BOREALIN N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED structural protein#PC00211 HELRO|EnsemblGenome=HelroG178929|UniProtKB=T1FDX0 T1FDX0 20207019 PTHR45713:SF15 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG69844|UniProtKB=T1FZY9 T1FZY9 20214387 PTHR22792:SF166 LUPUS LA PROTEIN-RELATED LUPUS LA PROTEIN HOMOLOG nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 positive regulation of gene expression#GO:0010628;positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of protein metabolic process#GO:0051247;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biological process#GO:0048518;positive regulation of translation#GO:0045727;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;cytosol#GO:0005829;cytoplasmic stress granule#GO:0010494;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG169896|UniProtKB=T1F2F1 T1F2F1 20203001 PTHR10792:SF1 60S RIBOSOMAL PROTEIN L24 RIBOSOMAL PROTEIN L24 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG114226|UniProtKB=T1EG03 T1EG03 20195505 PTHR45783:SF3 KINESIN LIGHT CHAIN KINESIN LIGHT CHAIN kinesin binding#GO:0019894;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;binding#GO:0005488 microtubule-based movement#GO:0007018;cellular process#GO:0009987;microtubule-based process#GO:0007017 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 Alzheimer disease-amyloid secretase pathway#P00003>kinesin#P00107 HELRO|EnsemblGenome=HelroG191050|UniProtKB=T1FSJ5 T1FSJ5 20211792 PTHR18911:SF5 CTCL TUMOR ANTIGEN HD-CL-01 COILED-COIL DOMAIN-CONTAINING PROTEIN 186 HELRO|EnsemblGenome=HelroG180782|UniProtKB=T1FG99 T1FG99 20207848 PTHR48249:SF3 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13 transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG111791|UniProtKB=T1EFE7 T1EFE7 20195299 PTHR11373:SF4 DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 cellular aromatic compound metabolic process#GO:0006725;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative metabolic process#GO:1901135;heterocycle catabolic process#GO:0046700;organonitrogen compound catabolic process#GO:1901565;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;purine-containing compound catabolic process#GO:0072523;phosphate-containing compound metabolic process#GO:0006796;cellular nitrogen compound catabolic process#GO:0044270;organic cyclic compound metabolic process#GO:1901360;purine nucleotide catabolic process#GO:0006195;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;purine nucleotide metabolic process#GO:0006163;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;nucleoside phosphate catabolic process#GO:1901292;carbohydrate derivative catabolic process#GO:1901136;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;nucleotide catabolic process#GO:0009166;nucleoside triphosphate catabolic process#GO:0009143;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organophosphate catabolic process#GO:0046434;primary metabolic process#GO:0044238;aromatic compound catabolic process#GO:0019439;organic cyclic compound catabolic process#GO:1901361;organophosphate metabolic process#GO:0019637;purine nucleoside triphosphate metabolic process#GO:0009144;nucleobase-containing compound catabolic process#GO:0034655;nucleotide metabolic process#GO:0009117;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG190063|UniProtKB=T1FRN0 T1FRN0 20211477 PTHR22948:SF29 TUDOR DOMAIN CONTAINING PROTEIN FI02030P-RELATED scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG174600|UniProtKB=T1F8A6 T1F8A6 20205055 PTHR11214:SF364 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE HEXOSYLTRANSFERASE transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG182431|UniProtKB=T1FI66 T1FI66 20208515 PTHR45798:SF97 RING-H2 FINGER PROTEIN ATL61-RELATED-RELATED ALCOHOL-SENSITIVE RING FINGER PROTEIN 1 HELRO|EnsemblGenome=HelroG155706|UniProtKB=T1ELL1 T1ELL1 20197461 PTHR15139:SF0 TUBULIN FOLDING COFACTOR C TUBULIN-SPECIFIC CHAPERONE C cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein-containing complex assembly#GO:0065003;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nitrogen compound metabolic process#GO:0006807;protein-containing complex organization#GO:0043933;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG116302|UniProtKB=T1EGE1 T1EGE1 20195643 PTHR12106:SF23 SORTILIN RELATED SORTILIN Golgi to endosome transport#GO:0006895;cellular localization#GO:0051641;post-Golgi vesicle-mediated transport#GO:0006892;transport#GO:0006810;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;cytosolic transport#GO:0016482;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;organelle organization#GO:0006996;vesicle organization#GO:0016050;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;import into cell#GO:0098657 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG114744|UniProtKB=T1EG44 T1EG44 20195546 PTHR45622:SF76 UBIQUITIN-PROTEIN LIGASE E3A-RELATED HECT AND RLD DOMAIN CONTAINING E3 UBIQUITIN LIGASE 4, ISOFORM C transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG73656|UniProtKB=T1G1G9 T1G1G9 20214917 PTHR12216:SF3 UROCANATE HYDRATASE UROCANATE HYDRATASE carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;catalytic activity#GO:0003824;hydro-lyase activity#GO:0016836 oxoacid metabolic process#GO:0043436;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;organic acid catabolic process#GO:0016054;amino acid catabolic process#GO:0009063;small molecule catabolic process#GO:0044282;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;carboxylic acid metabolic process#GO:0019752;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;cellular catabolic process#GO:0044248 lyase#PC00144;hydratase#PC00120 HELRO|EnsemblGenome=HelroG173956|UniProtKB=T1F7E9 T1F7E9 20204748 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166983|UniProtKB=T1EYU5 T1EYU5 20201745 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194139|UniProtKB=T1FVR0 T1FVR0 20212906 PTHR13793:SF160 PHD FINGER PROTEINS PHD FINGER PROTEIN RHINOCEROS regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG193281|UniProtKB=T1FUT9 T1FUT9 20212585 PTHR13043:SF1 EXOCYST COMPLEX COMPONENT SEC5 EXOCYST COMPLEX COMPONENT 2 localization#GO:0051179;localization within membrane#GO:0051668;cellular localization#GO:0051641;vesicle-mediated transport to the plasma membrane#GO:0098876;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;post-Golgi vesicle-mediated transport#GO:0006892;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;Golgi to plasma membrane transport#GO:0006893;export from cell#GO:0140352;secretion by cell#GO:0032940 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;vesicle tethering complex#GO:0099023;exocyst#GO:0000145;cell cortex#GO:0005938;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 Ras Pathway#P04393>Sec5#P04545 HELRO|EnsemblGenome=HelroG189614|UniProtKB=T1FR74 T1FR74 20211321 PTHR23114:SF17 M7GPPPN-MRNA HYDROLASE M7GPPPN-MRNA HYDROLASE cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG171506|UniProtKB=T1F4C9 T1F4C9 20203678 PTHR10912:SF7 ADP-RIBOSYL CYCLASE ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE lyase activity#GO:0016829;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824 regulation of multicellular organismal process#GO:0051239;regulation of cell population proliferation#GO:0042127;positive regulation of cell population proliferation#GO:0008284;positive regulation of immune system process#GO:0002684;positive regulation of lymphocyte activation#GO:0051251;positive regulation of leukocyte activation#GO:0002696;positive regulation of cellular process#GO:0048522;regulation of cell activation#GO:0050865;regulation of biological process#GO:0050789;regulation of leukocyte activation#GO:0002694;regulation of mononuclear cell proliferation#GO:0032944;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of lymphocyte proliferation#GO:0050670;regulation of immune system process#GO:0002682;regulation of leukocyte proliferation#GO:0070663;positive regulation of cell activation#GO:0050867;regulation of lymphocyte activation#GO:0051249;positive regulation of biological process#GO:0048518;regulation of B cell proliferation#GO:0030888;positive regulation of multicellular organismal process#GO:0051240 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 cyclase#PC00079;lyase#PC00144 HELRO|EnsemblGenome=HelroG194143|UniProtKB=T1FVR4 T1FVR4 20212910 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG102897|UniProtKB=T1EDC9 T1EDC9 20194581 PTHR24210:SF0 LIM DOMAIN-CONTAINING PROTEIN LIM DOMAIN-CONTAINING PROTEIN cell junction protein#PC00070 Integrin signalling pathway#P00034>PINCH#P00921 HELRO|EnsemblGenome=HelroG184857|UniProtKB=T1FM33 T1FM33 20209882 PTHR12277:SF194 ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN FI04476P hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;phospholipase activity#GO:0004620;catalytic activity#GO:0003824;lysophospholipase activity#GO:0004622 lipid metabolic process#GO:0006629;neutral lipid catabolic process#GO:0046461;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;glycerophospholipid metabolic process#GO:0006650;glycerolipid catabolic process#GO:0046503;lipid catabolic process#GO:0016042;glycerophospholipid catabolic process#GO:0046475;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;acylglycerol metabolic process#GO:0006639;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate catabolic process#GO:0046434;acylglycerol catabolic process#GO:0046464;phosphate-containing compound metabolic process#GO:0006796;neutral lipid metabolic process#GO:0006638;glycerolipid metabolic process#GO:0046486;nitrogen compound metabolic process#GO:0006807;cellular modified amino acid metabolic process#GO:0006575;phospholipid catabolic process#GO:0009395;catabolic process#GO:0009056;organophosphate metabolic process#GO:0019637;organic substance catabolic process#GO:1901575;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG190234|UniProtKB=T1FRS9 T1FRS9 20211526 PTHR21425:SF2 NICE-3 PROTEIN C1ORF43 HELRO|EnsemblGenome=HelroG104783|UniProtKB=T1EDN6 T1EDN6 20194688 PTHR24390:SF245 ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG176769|UniProtKB=T1FAW3 T1FAW3 20205962 PTHR18945:SF925 NEUROTRANSMITTER GATED ION CHANNEL DUF4706 DOMAIN-CONTAINING PROTEIN ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG162330|UniProtKB=T1ESI6 T1ESI6 20199536 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194237|UniProtKB=T1FVU6 T1FVU6 20212942 PTHR10332:SF88 EQUILIBRATIVE NUCLEOSIDE TRANSPORTER EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1, ISOFORM A carbohydrate derivative transmembrane transporter activity#GO:1901505;nucleobase-containing compound transmembrane transporter activity#GO:0015932;nucleoside transmembrane transporter activity#GO:0005337;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG184114|UniProtKB=T1FKL7 T1FKL7 20209366 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182706|UniProtKB=T1FIM1 T1FIM1 20208670 PTHR11452:SF83 ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE ALPHA-GALACTOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 carbohydrate derivative metabolic process#GO:1901135;glycosyl compound catabolic process#GO:1901658;carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;glycosyl compound metabolic process#GO:1901657;carbohydrate metabolic process#GO:0005975;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 galactosidase#PC00104;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG112427|UniProtKB=T1EFJ8 T1EFJ8 20195350 PTHR11685:SF441 RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING RBR-TYPE E3 UBIQUITIN TRANSFERASE ubiquitin-like protein conjugating enzyme binding#GO:0044390;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;enzyme binding#GO:0019899;protein binding#GO:0005515;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG188265|UniProtKB=T1FPT6 T1FPT6 20210833 PTHR13364:SF6 DEFECTIVE SPERMATOGENESIS PROTEIN 39 SPERMATOGENESIS-DEFECTIVE PROTEIN 39 HOMOLOG cellular localization#GO:0051641;macromolecule localization#GO:0033036;vacuolar transport#GO:0007034;transport#GO:0006810;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG96420|UniProtKB=T1G9C0 T1G9C0 20217667 PTHR22847:SF637 WD40 REPEAT PROTEIN WD REPEAT DOMAIN 5B HELRO|EnsemblGenome=HelroG188601|UniProtKB=T1FQ60 T1FQ60 20210957 PTHR11884:SF1 SELECTIN LIGAND RELATED GOLGI APPARATUS PROTEIN 1 HELRO|EnsemblGenome=HelroG88048|UniProtKB=T1G6X9 T1G6X9 20216826 PTHR13048:SF0 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;establishment of localization#GO:0051234;intra-Golgi vesicle-mediated transport#GO:0006891;transport#GO:0006810;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193 bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;vesicle tethering complex#GO:0099023;TRAPP complex#GO:0030008;Golgi apparatus#GO:0005794;cytosol#GO:0005829;organelle membrane#GO:0031090;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cis-Golgi network#GO:0005801;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG173594|UniProtKB=T1F701 T1F701 20204600 PTHR31362:SF0 GLYCOSYLTRANSFERASE STELLO1-RELATED EXOSTOSIN DOMAIN-CONTAINING PROTEIN-RELATED glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG191549|UniProtKB=T1FT25 T1FT25 20211972 PTHR14139:SF2 CALSYNTENIN CALSYNTENIN-1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG172392|UniProtKB=T1F590 T1F590 20203989 PTHR24246:SF27 OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR ADENOSINE RECEPTOR, ISOFORM A G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HELRO|EnsemblGenome=HelroG165877|UniProtKB=T1EXE2 T1EXE2 20201242 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG160645|UniProtKB=T1EQJ8 T1EQJ8 20198848 PTHR22255:SF9 LP06548P LP06548P HELRO|EnsemblGenome=HelroG162077|UniProtKB=T1ES82 T1ES82 20199432 PTHR46770:SF1 HOMEOBOX PROTEIN ORTHOPEDIA HOMEOBOX PROTEIN ORTHOPEDIA nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 cell differentiation#GO:0030154;cellular developmental process#GO:0048869;system development#GO:0048731;neurogenesis#GO:0022008;anatomical structure development#GO:0048856;multicellular organism development#GO:0007275;developmental process#GO:0032502;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;cellular process#GO:0009987;nervous system development#GO:0007399 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG176525|UniProtKB=T1FAM2 T1FAM2 20205871 PTHR47827:SF3 AHD DOMAIN-CONTAINING PROTEIN AF-9 ANC1 HOMOLOGY DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;protein-containing complex binding#GO:0044877;histone binding#GO:0042393;binding#GO:0005488;chromatin binding#GO:0003682;modification-dependent protein binding#GO:0140030 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;transcription elongation factor complex#GO:0008023;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG157793|UniProtKB=T1EMF9 T1EMF9 20197759 PTHR10217:SF435 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EAG monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG77440|UniProtKB=T1G2X7 T1G2X7 20215425 PTHR12770:SF31 RUS1 FAMILY PROTEIN C16ORF58 RUS FAMILY MEMBER 1 HELRO|EnsemblGenome=HelroG111709|UniProtKB=T1EFE0 T1EFE0 20195292 PTHR24409:SF420 ZINC FINGER PROTEIN 142 IP01303P sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG123385|UniProtKB=T1EGX7 T1EGX7 20195827 PTHR10068:SF14 BONE MARROW PROTEOGLYCAN CELL WALL ADHESIN EAP1 extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG84170|UniProtKB=T1G5F9 T1G5F9 20216306 PTHR24346:SF82 MAP/MICROTUBULE AFFINITY-REGULATING KINASE KP78A-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG106117|UniProtKB=T1EE02 T1EE02 20194804 PTHR11561:SF0 PHOSPHOENOLPYRUVATE CARBOXYKINASE PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP]-RELATED cation binding#GO:0043169;carboxy-lyase activity#GO:0016831;carbon-carbon lyase activity#GO:0016830;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;lyase activity#GO:0016829;ion binding#GO:0043167 dicarboxylic acid metabolic process#GO:0043648;alcohol biosynthetic process#GO:0046165;lipid catabolic process#GO:0016042;response to extracellular stimulus#GO:0009991;acylglycerol metabolic process#GO:0006639;lipid biosynthetic process#GO:0008610;neutral lipid metabolic process#GO:0006638;triglyceride biosynthetic process#GO:0019432;carboxylic acid catabolic process#GO:0046395;cellular lipid catabolic process#GO:0044242;organic substance metabolic process#GO:0071704;organic hydroxy compound metabolic process#GO:1901615;oxoacid metabolic process#GO:0043436;response to oxygen-containing compound#GO:1901700;cellular response to organic substance#GO:0071310;cellular metabolic process#GO:0044237;alcohol metabolic process#GO:0006066;intracellular chemical homeostasis#GO:0055082;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;hexose biosynthetic process#GO:0019319;organic acid catabolic process#GO:0016054;response to glucose#GO:0009749;small molecule catabolic process#GO:0044282;response to stress#GO:0006950;small molecule biosynthetic process#GO:0044283;carbohydrate homeostasis#GO:0033500;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329;lipid metabolic process#GO:0006629;monosaccharide metabolic process#GO:0005996;response to lipid#GO:0033993;organic hydroxy compound biosynthetic process#GO:1901617;biosynthetic process#GO:0009058;cellular homeostasis#GO:0019725;cellular response to oxygen-containing compound#GO:1901701;glycerolipid metabolic process#GO:0046486;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carbohydrate metabolic process#GO:0005975;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;response to organic substance#GO:0010033;carbohydrate biosynthetic process#GO:0016051;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;triglyceride metabolic process#GO:0006641;glycerolipid biosynthetic process#GO:0045017;glucose homeostasis#GO:0042593;homeostatic process#GO:0042592;cellular biosynthetic process#GO:0044249;response to nutrient levels#GO:0031667;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;chemical homeostasis#GO:0048878;glucose metabolic process#GO:0006006;fatty acid catabolic process#GO:0009062;response to external stimulus#GO:0009605;response to stimulus#GO:0050896;intracellular glucose homeostasis#GO:0001678;fatty acid metabolic process#GO:0006631;response to chemical#GO:0042221;response to starvation#GO:0042594;hexose metabolic process#GO:0019318;cellular lipid metabolic process#GO:0044255;carboxylic acid metabolic process#GO:0019752 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 kinase#PC00137 Pyruvate metabolism#P02772>Phosphoenolpyruvate Carboxykinase#P03135 HELRO|EnsemblGenome=HelroG91834|UniProtKB=T1G896 T1G896 20217293 PTHR23417:SF16 3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE tRNA methyltransferase activity#GO:0008175;catalytic activity, acting on RNA#GO:0140098;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;RNA methyltransferase activity#GO:0008173 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;macromolecule methylation#GO:0043414;tRNA methylation#GO:0030488;organic cyclic compound metabolic process#GO:1901360;methylation#GO:0032259;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;RNA methylation#GO:0001510;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 methyltransferase complex#GO:0034708;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG189892|UniProtKB=T1FRG4 T1FRG4 20211411 PTHR45695:SF15 LEUCOKININ RECEPTOR-RELATED OPSIN RH2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Rhodopsin#P00747 HELRO|EnsemblGenome=HelroG188774|UniProtKB=T1FQC4 T1FQC4 20211021 PTHR46292:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 102A COILED-COIL DOMAIN-CONTAINING PROTEIN 102A HELRO|EnsemblGenome=HelroG157108|UniProtKB=T1EM61 T1EM61 20197661 PTHR10552:SF6 U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A' RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG79798|UniProtKB=T1G3T4 T1G3T4 20215732 PTHR24637:SF377 COLLAGEN COLLAGEN TYPE IX ALPHA 1 CHAIN HELRO|EnsemblGenome=HelroG82781|UniProtKB=T1G4W5 T1G4W5 20216113 PTHR11767:SF102 INWARD RECTIFIER POTASSIUM CHANNEL INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of localization#GO:0032879;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;import across plasma membrane#GO:0098739;regulation of transport#GO:0051049;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;regulation of monoatomic ion transport#GO:0043269;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;potassium ion transport#GO:0006813;potassium ion import across plasma membrane#GO:1990573 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG96204|UniProtKB=T1G9A7 T1G9A7 20217654 PTHR12117:SF0 HISTONE ACETYLTRANSFERASE COMPLEX PROLYL 3-HYDROXYLASE OGFOD1 histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG176599|UniProtKB=T1FAP7 T1FAP7 20205896 PTHR33865:SF3 PROTEIN FAM183B PROTEIN FAM183B membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cilium#GO:0005929;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;ciliary base#GO:0097546 HELRO|EnsemblGenome=HelroG90168|UniProtKB=T1G7L8 T1G7L8 20217065 PTHR21321:SF1 PNAS-3 RELATED EXOSOME COMPLEX COMPONENT RRP40 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159 negative regulation of gene expression#GO:0010629;tRNA metabolic process#GO:0006399;cellular component biogenesis#GO:0044085;regulation of catabolic process#GO:0009894;heterocycle catabolic process#GO:0046700;regulation of nitrogen compound metabolic process#GO:0051171;rRNA processing#GO:0006364;positive regulation of cellular metabolic process#GO:0031325;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA destabilization#GO:0050779;modification-dependent macromolecule catabolic process#GO:0043632;regulation of biological process#GO:0050789;ncRNA metabolic process#GO:0034660;mRNA metabolic process#GO:0016071;regulation of biological quality#GO:0065008;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;snRNA 3'-end processing#GO:0034472;ribosome biogenesis#GO:0042254;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;cellular component organization or biogenesis#GO:0071840;positive regulation of mRNA catabolic process#GO:0061014;regulation of cellular process#GO:0050794;rRNA metabolic process#GO:0016072;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of catabolic process#GO:0009896;mRNA destabilization#GO:0061157;nucleobase-containing compound catabolic process#GO:0034655;polyadenylation-dependent ncRNA catabolic process#GO:0043634;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323;positive regulation of nitrogen compound metabolic process#GO:0051173;cellular aromatic compound metabolic process#GO:0006725;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of mRNA stability#GO:0043488;regulation of mRNA catabolic process#GO:0061013;RNA metabolic process#GO:0016070;positive regulation of cellular catabolic process#GO:0031331;RNA processing#GO:0006396;biosynthetic process#GO:0009058;cellular nitrogen compound catabolic process#GO:0044270;positive regulation of metabolic process#GO:0009893;organic cyclic compound metabolic process#GO:1901360;mRNA catabolic process#GO:0006402;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;snRNA processing#GO:0016180;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;maturation of 5.8S rRNA#GO:0000460;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;positive regulation of mRNA metabolic process#GO:1903313;heterocycle metabolic process#GO:0046483;snRNA metabolic process#GO:0016073;macromolecule biosynthetic process#GO:0009059;negative regulation of biosynthetic process#GO:0009890;RNA 3'-end processing#GO:0031123;cellular biosynthetic process#GO:0044249;nuclear-transcribed mRNA catabolic process#GO:0000956;organic substance biosynthetic process#GO:1901576;regulation of cellular catabolic process#GO:0031329;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;regulation of cellular biosynthetic process#GO:0031326;aromatic compound catabolic process#GO:0019439;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;ribonucleoprotein complex biogenesis#GO:0022613;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;positive regulation of RNA metabolic process#GO:0051254 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513;exosome (RNase complex)#GO:0000178 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG182832|UniProtKB=T1FIT9 T1FIT9 20208738 PTHR11360:SF260 MONOCARBOXYLATE TRANSPORTER MFS DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;monocarboxylic acid transmembrane transporter activity#GO:0008028;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;monocarboxylic acid transport#GO:0015718;establishment of localization#GO:0051234;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942 transporter#PC00227 HELRO|EnsemblGenome=HelroG76935|UniProtKB=T1G2R7 T1G2R7 20215365 PTHR43918:SF12 ACETYLCHOLINESTERASE ACETYLCHOLINESTERASE 1 hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;extracellular space#GO:0005615;membrane#GO:0016020;extracellular region#GO:0005576;plasma membrane#GO:0005886 esterase#PC00097;hydrolase#PC00121 Nicotinic acetylcholine receptor signaling pathway#P00044>AChE#P01093;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>AChE#P01067;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>AChE#P01080 HELRO|EnsemblGenome=HelroG177668|UniProtKB=T1FC15 T1FC15 20206364 PTHR14155:SF627 RING FINGER DOMAIN-CONTAINING OS06G0192800 PROTEIN ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG184684|UniProtKB=T1FLR6 T1FLR6 20209765 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED BRCT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG154179|UniProtKB=T1ELD9 T1ELD9 20197389 PTHR11893:SF36 INNEXIN INNEXIN-5 cell junction protein#PC00070;gap junction#PC00105 HELRO|EnsemblGenome=HelroG66983|UniProtKB=T1FYU6 T1FYU6 20213994 PTHR47023:SF1 SEX PEPTIDE RECEPTOR SEX PEPTIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG65701|UniProtKB=T1FYB6 T1FYB6 20213814 PTHR16301:SF25 IMPACT-RELATED PROTEIN IMPACT cellular response to stimulus#GO:0051716;regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;cellular process#GO:0009987;regulation of translational initiation#GO:0006446;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular biosynthetic process#GO:0031326;response to stress#GO:0006950;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;cellular response to stress#GO:0033554;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG163326|UniProtKB=T1ETX0 T1ETX0 20200020 PTHR16267:SF11 BANK1/PIK3AP1 FAMILY MEMBER STUMPS, ISOFORM E protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 HELRO|EnsemblGenome=HelroG95842|UniProtKB=T1G982 T1G982 20217629 PTHR11953:SF0 EXOSOME COMPLEX COMPONENT EXOSOME COMPLEX COMPONENT RRP41 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular nitrogen compound catabolic process#GO:0044270;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;organic cyclic compound metabolic process#GO:1901360;rRNA metabolic process#GO:0016072;nitrogen compound metabolic process#GO:0006807;organic cyclic compound catabolic process#GO:1901361;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;organic substance catabolic process#GO:1901575;nucleobase-containing compound catabolic process#GO:0034655;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248 RNA metabolism protein#PC00031;exoribonuclease#PC00099 HELRO|EnsemblGenome=HelroG174630|UniProtKB=T1F8B5 T1F8B5 20205064 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG75061|UniProtKB=T1G201 T1G201 20215099 PTHR11993:SF10 NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG179349|UniProtKB=T1FEL1 T1FEL1 20207260 PTHR22906:SF21 PROPERDIN SEMA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169950|UniProtKB=T1F2H0 T1F2H0 20203020 PTHR13551:SF1 BRAIN PROTEIN I3 MEMBRANE PROTEIN BRI3 HELRO|EnsemblGenome=HelroG129652|UniProtKB=T1EHS0 T1EHS0 20196120 PTHR45134:SF22 OS08G0543275 PROTEIN G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG96859|UniProtKB=T1G9D9 T1G9D9 20217686 PTHR13090:SF1 ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL HELRO|EnsemblGenome=HelroG192950|UniProtKB=T1FUG2 T1FUG2 20212458 PTHR12121:SF34 CARBON CATABOLITE REPRESSOR PROTEIN 4 PROTEIN ANGEL catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787;3'-5'-RNA exonuclease activity#GO:0000175;exonuclease activity#GO:0004527;3'-5' exonuclease activity#GO:0008408;RNA nuclease activity#GO:0004540 mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG193588|UniProtKB=T1FV53 T1FV53 20212699 PTHR12809:SF2 MEDIATOR COMPLEX SUBUNIT MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14 molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;core mediator complex#GO:0070847;RNA polymerase II transcription regulator complex#GO:0090575;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG181083|UniProtKB=T1FGL6 T1FGL6 20207965 PTHR21493:SF9 CGI-141-RELATED/LIPASE CONTAINING PROTEIN GOLGI TRANSPORT PROTEIN 1-RELATED lipase#PC00143;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG185094|UniProtKB=T1FME0 T1FME0 20209989 PTHR13050:SF7 USE1-LIKE PROTEIN VESICLE TRANSPORT PROTEIN USE1 molecular adaptor activity#GO:0060090;SNAP receptor activity#GO:0005484;protein-macromolecule adaptor activity#GO:0030674 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;Golgi vesicle transport#GO:0048193;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;transport#GO:0006810 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;SNARE complex#GO:0031201;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG191738|UniProtKB=T1FT90 T1FT90 20212037 PTHR23147:SF75 SERINE/ARGININE RICH SPLICING FACTOR OS01G0155600 PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;nuclear speck#GO:0016607;organelle#GO:0043226;nuclear body#GO:0016604;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG73849|UniProtKB=T1G1J4 T1G1J4 20214942 PTHR10574:SF435 NETRIN/LAMININ-RELATED LAMININ SUBUNIT GAMMA-1 neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;cell projection organization#GO:0030030;animal organ development#GO:0048513;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;axonogenesis#GO:0007409;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization#GO:0016043;cell morphogenesis#GO:0000902;cellular process#GO:0009987;tissue development#GO:0009888;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure development#GO:0048856;animal organ morphogenesis#GO:0009887;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Laminin#P00947 HELRO|EnsemblGenome=HelroG106880|UniProtKB=T1EE56 T1EE56 20194858 PTHR45876:SF8 FI04035P FI04035P nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;GTPase regulator activity#GO:0030695;molecular function activator activity#GO:0140677;GTPase activator activity#GO:0005096;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG189086|UniProtKB=T1FQM4 T1FQM4 20211121 PTHR19854:SF1 TRANSDUCIN BETA-LIKE 3 GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG77058|UniProtKB=T1G2S8 T1G2S8 20215376 PTHR11800:SF13 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;RNA polymerase activity#GO:0097747;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;RNA polymerase III activity#GO:0001056;RNA polymerase I activity#GO:0001054 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;RNA polymerase III complex#GO:0005666;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;RNA polymerase I complex#GO:0005736;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG165641|UniProtKB=T1EX41 T1EX41 20201141 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG134329|UniProtKB=T1EI44 T1EI44 20196244 PTHR45614:SF25 MYB PROTEIN-RELATED MYB PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG172376|UniProtKB=T1F586 T1F586 20203985 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177161|UniProtKB=T1FBA6 T1FBA6 20206105 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG99722|UniProtKB=T1G9U7 T1G9U7 20217843 PTHR11905:SF159 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG189288|UniProtKB=T1FQX2 T1FQX2 20211219 PTHR19879:SF1 TRANSCRIPTION INITIATION FACTOR TFIID CANNONBALL-RELATED cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;transcription initiation at RNA polymerase II promoter#GO:0006367;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nucleobase-containing compound biosynthetic process#GO:0034654;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;transcription factor TFIID complex#GO:0005669;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase II, holoenzyme#GO:0016591;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG107319|UniProtKB=T1EE95 T1EE95 20194897 PTHR24034:SF200 EGF-LIKE DOMAIN-CONTAINING PROTEIN EGF-LIKE AND EMI DOMAIN-CONTAINING PROTEIN 1 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG170286|UniProtKB=T1F2V8 T1F2V8 20203157 PTHR48033:SF9 RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN TAR DNA-BINDING PROTEIN 43 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG132066|UniProtKB=T1EHX2 T1EHX2 20196172 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;heme binding#GO:0020037 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG84937|UniProtKB=T1G5Q5 T1G5Q5 20216402 PTHR11929:SF145 ALPHA- 1,3 -FUCOSYLTRANSFERASE ALPHA-(1,3)-FUCOSYLTRANSFERASE FUT-1 transferase activity#GO:0016740;fucosyltransferase activity#GO:0008417;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycosylation#GO:0070085;metabolic process#GO:0008152 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG66381|UniProtKB=T1FYK4 T1FYK4 20213902 PTHR10183:SF433 CALPAIN CALPAIN-A-RELATED cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protease#PC00190 Huntington disease#P00029>Calpain#P00788 HELRO|EnsemblGenome=HelroG171272|UniProtKB=T1F405 T1F405 20203554 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG176145|UniProtKB=T1FA73 T1FA73 20205722 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163072|UniProtKB=T1ETM5 T1ETM5 20199925 PTHR46016:SF1 ZINC FINGER, RING/FYVE/PHD-TYPE RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 HELRO|EnsemblGenome=HelroG130073|UniProtKB=T1EHT0 T1EHT0 20196130 PTHR24229:SF40 NEUROPEPTIDES RECEPTOR ALLATOSTATIN C RECEPTOR 1-RELATED G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HELRO|EnsemblGenome=HelroG194847|UniProtKB=T1FWH3 T1FWH3 20213168 PTHR18861:SF0 ELKS/RAB6-INTERACTING/CAST PROTEIN BRUCHPILOT, ISOFORM J membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG192596|UniProtKB=T1FU41 T1FU41 20212337 PTHR10574:SF435 NETRIN/LAMININ-RELATED LAMININ SUBUNIT GAMMA-1 neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;cell projection organization#GO:0030030;animal organ development#GO:0048513;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;axonogenesis#GO:0007409;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization#GO:0016043;cell morphogenesis#GO:0000902;cellular process#GO:0009987;tissue development#GO:0009888;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure development#GO:0048856;animal organ morphogenesis#GO:0009887;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Laminin#P00947 HELRO|EnsemblGenome=HelroG114157|UniProtKB=T1EFZ7 T1EFZ7 20195499 PTHR48021:SF1 FAMILY NOT NAMED GH07001P-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG73737|UniProtKB=T1G1H8 T1G1H8 20214926 PTHR11048:SF28 PRENYLTRANSFERASES 4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL transferase activity#GO:0016740;catalytic activity#GO:0003824 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 acyltransferase#PC00042 Heme biosynthesis#P02746>Protoheme IX farnesyl transferase#P02982 HELRO|EnsemblGenome=HelroG159619|UniProtKB=T1EP90 T1EP90 20198390 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157320|UniProtKB=T1EM97 T1EM97 20197697 PTHR43977:SF1 STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3 STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3 HELRO|EnsemblGenome=HelroG190570|UniProtKB=T1FS37 T1FS37 20211634 PTHR13598:SF1 AT07567P-RELATED AT07567P-RELATED HELRO|EnsemblGenome=HelroG185907|UniProtKB=T1FNF4 T1FNF4 20210351 PTHR19957:SF83 SYNTAXIN SYNTAXIN-16 molecular adaptor activity#GO:0060090;protein binding#GO:0005515;SNAP receptor activity#GO:0005484;binding#GO:0005488;SNARE binding#GO:0000149;protein-macromolecule adaptor activity#GO:0030674 vesicle fusion#GO:0006906;cellular localization#GO:0051641;organelle localization#GO:0051640;macromolecule localization#GO:0033036;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;membrane fusion#GO:0061025;establishment of localization#GO:0051234;organelle organization#GO:0006996;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;vesicle organization#GO:0016050;intracellular transport#GO:0046907;organelle fusion#GO:0048284 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;SNARE complex#GO:0031201;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034;membrane traffic protein#PC00150 Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079 HELRO|EnsemblGenome=HelroG171382|UniProtKB=T1F477 T1F477 20203626 PTHR46601:SF1 ULP_PROTEASE DOMAIN-CONTAINING PROTEIN ADF-H DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185361|UniProtKB=T1FMQ3 T1FMQ3 20210102 PTHR19282:SF456 TETRASPANIN CD63 MOLECULE cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG190028|UniProtKB=T1FRL9 T1FRL9 20211466 PTHR22619:SF1 ZINC FINGER SWIM DOMAIN CONTAINING PROTEIN 4, 5, 6 ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 8 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234 HELRO|EnsemblGenome=HelroG75694|UniProtKB=T1G291 T1G291 20215189 PTHR11829:SF388 FORKHEAD BOX PROTEIN FORK HEAD DOMAIN-CONTAINING PROTEIN L1-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;anatomical structure morphogenesis#GO:0009653;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG64443|UniProtKB=T1FXV0 T1FXV0 20213648 PTHR10110:SF187 SODIUM/HYDROGEN EXCHANGER SODIUM_HYDROGEN EXCHANGER secondary active transmembrane transporter activity#GO:0015291;inorganic molecular entity transmembrane transporter activity#GO:0015318;antiporter activity#GO:0015297;transmembrane transporter activity#GO:0022857;potassium ion transmembrane transporter activity#GO:0015079;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;proton transmembrane transporter activity#GO:0015078;metal cation:proton antiporter activity#GO:0051139;active monoatomic ion transmembrane transporter activity#GO:0022853;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;inorganic cation transmembrane transporter activity#GO:0022890;transporter activity#GO:0005215 regulation of intracellular pH#GO:0051453;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;regulation of pH#GO:0006885;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;regulation of cellular pH#GO:0030641;import into cell#GO:0098657;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG103366|UniProtKB=T1EDF9 T1EDF9 20194611 PTHR43948:SF10 DNAJ HOMOLOG SUBFAMILY B MRJ, ISOFORM E chaperone#PC00072 HELRO|EnsemblGenome=HelroG109653|UniProtKB=T1EEV6 T1EEV6 20195108 PTHR24406:SF24 TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED IP01015P-RELATED nucleic acid binding#GO:0003676;protein-containing complex binding#GO:0044877;chromatin DNA binding#GO:0031490;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG175087|UniProtKB=T1F8U2 T1F8U2 20205241 PTHR25462:SF305 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG156441|UniProtKB=T1ELW7 T1ELW7 20197567 PTHR46493:SF1 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP3 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP3 chaperone#PC00072 HELRO|EnsemblGenome=HelroG74366|UniProtKB=T1G1Q1 T1G1Q1 20214999 PTHR22762:SF54 ALPHA-GLUCOSIDASE BCDNA.GH04962 hydrolase activity#GO:0016787;glucosidase activity#GO:0015926;hydrolase activity, acting on glycosyl bonds#GO:0016798;alpha-glucosidase activity#GO:0090599;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 carbohydrate derivative metabolic process#GO:1901135;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 glucosidase#PC00108;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG164536|UniProtKB=T1EVJ8 T1EVJ8 20200598 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG177701|UniProtKB=T1FC37 T1FC37 20206386 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG156183|UniProtKB=T1ELS3 T1ELS3 20197523 PTHR23086:SF8 PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301;lipid kinase activity#GO:0001727 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 kinase#PC00137 HELRO|EnsemblGenome=HelroG94839|UniProtKB=T1G934 T1G934 20217581 PTHR10336:SF80 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN C2 DOMAIN-CONTAINING PROTEIN hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phospholipase C activity#GO:0004629;phospholipase activity#GO:0004620;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578 lipid metabolic process#GO:0006629;signal transduction#GO:0007165;negative regulation of biological process#GO:0048519;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of sequestering of calcium ion#GO:0051282;regulation of localization#GO:0032879;inorganic ion transmembrane transport#GO:0098660;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;calcium ion transport#GO:0006816;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;glycerolipid metabolic process#GO:0046486;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;intracellular signal transduction#GO:0035556;signaling#GO:0023052;negative regulation of cellular process#GO:0048523;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular response to stimulus#GO:0051716;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;cellular metabolic process#GO:0044237;release of sequestered calcium ion into cytosol#GO:0051209;cell communication#GO:0007154;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;cellular process#GO:0009987;primary metabolic process#GO:0044238;localization#GO:0051179;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;calcium ion transmembrane import into cytosol#GO:0097553;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;monoatomic ion transport#GO:0006811;cellular lipid metabolic process#GO:0044255;negative regulation of sequestering of calcium ion#GO:0051283;monoatomic cation transmembrane transport#GO:0098655 phospholipase#PC00186 HELRO|EnsemblGenome=HelroG174588|UniProtKB=T1F8A1 T1F8A1 20205050 PTHR12320:SF78 PROTEIN PHOSPHATASE 2C SUBFAMILY NOT NAMED hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;dephosphorylation#GO:0016311;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185009|UniProtKB=T1FM99 T1FM99 20209948 PTHR43160:SF3 ACONITATE HYDRATASE B ACONITATE HYDRATASE, MITOCHONDRIAL carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;small molecule binding#GO:0036094;binding#GO:0005488;iron-sulfur cluster binding#GO:0051536;catalytic activity#GO:0003824;hydro-lyase activity#GO:0016836 aerobic respiration#GO:0009060;cellular respiration#GO:0045333;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;cellular process#GO:0009987;tricarboxylic acid cycle#GO:0006099;energy derivation by oxidation of organic compounds#GO:0015980;primary metabolic process#GO:0044238;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 lyase#PC00144;hydratase#PC00120 TCA cycle#P00051>Aconitase#P01268 HELRO|EnsemblGenome=HelroG162653|UniProtKB=T1ESZ0 T1ESZ0 20199690 PTHR23068:SF25 DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED DNA (CYTOSINE-5)-METHYLTRANSFERASE DRM2 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA methyltransferase#PC00013 HELRO|EnsemblGenome=HelroG182655|UniProtKB=T1FIJ7 T1FIJ7 20208646 PTHR24082:SF506 NUCLEAR HORMONE RECEPTOR NR LBD DOMAIN-CONTAINING PROTEIN C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG192453|UniProtKB=T1FTZ4 T1FTZ4 20212291 PTHR12585:SF27 SCC1 / RAD21 FAMILY MEMBER MEIOTIC RECOMBINATION PROTEIN REC8 HOMOLOG protein-containing complex binding#GO:0044877;binding#GO:0005488;chromatin binding#GO:0003682 DNA repair#GO:0006281;meiotic sister chromatid cohesion#GO:0051177;cellular aromatic compound metabolic process#GO:0006725;double-strand break repair#GO:0006302;cell cycle process#GO:0022402;nucleobase-containing compound metabolic process#GO:0006139;sister chromatid cohesion#GO:0007062;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;recombinational repair#GO:0000725;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;double-strand break repair via homologous recombination#GO:0000724;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;replication-born double-strand break repair via sister chromatid exchange#GO:1990414;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;chromosome organization#GO:0051276;organelle organization#GO:0006996;cell cycle#GO:0007049;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;cohesin complex#GO:0008278;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG190246|UniProtKB=T1FRT3 T1FRT3 20211530 PTHR18966:SF422 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED signaling receptor activity#GO:0038023;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;ligand-gated channel activity#GO:0022834 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019 HELRO|EnsemblGenome=HelroG194496|UniProtKB=T1FW44 T1FW44 20213040 PTHR24104:SF51 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG83543|UniProtKB=T1G569 T1G569 20216217 PTHR12532:SF0 TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1 TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1 HELRO|EnsemblGenome=HelroG67330|UniProtKB=T1FYZ8 T1FYZ8 20214046 PTHR30521:SF0 DEFERROCHELATASE/PEROXIDASE DYP-TYPE PEROXIDASE FAMILY PROTEIN antioxidant activity#GO:0016209;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;tetrapyrrole binding#GO:0046906;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;oxidoreductase activity#GO:0016491;heme binding#GO:0020037 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 peroxidase#PC00180;oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG75228|UniProtKB=T1G228 T1G228 20215126 PTHR11937:SF491 ACTIN PH DOMAIN-CONTAINING PROTEIN intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 actin and actin related protein#PC00039;cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG165645|UniProtKB=T1EX43 T1EX43 20201143 PTHR12850:SF5 40S RIBOSOMAL PROTEIN S25 SMALL RIBOSOMAL SUBUNIT PROTEIN ES25 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;small ribosomal subunit#GO:0015935;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG161680|UniProtKB=T1ERS3 T1ERS3 20199273 PTHR24044:SF421 NOTCH LIGAND FAMILY MEMBER PROTEIN JAGGED-2 protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 intercellular signal molecule#PC00207 Notch signaling pathway#P00045>Next#P01103;Angiogenesis#P00005>Delta/Serrate#P00226;Notch signaling pathway#P00045>Serrate#P01104 HELRO|EnsemblGenome=HelroG164153|UniProtKB=T1EV04 T1EV04 20200404 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167047|UniProtKB=T1EYY0 T1EYY0 20201780 PTHR13581:SF5 MRG-BINDING PROTEIN MRG_MORF4L-BINDING PROTEIN regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;NuA4 histone acetyltransferase complex#GO:0035267;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;chromosome#GO:0005694 HELRO|EnsemblGenome=HelroG184840|UniProtKB=T1FM26 T1FM26 20209875 PTHR13664:SF0 BECLIN 1-ASSOCIATED AUTOPHAGY-RELATED KEY REGULATOR BECLIN 1-ASSOCIATED AUTOPHAGY-RELATED KEY REGULATOR protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234;protein-macromolecule adaptor activity#GO:0030674 cellular component biogenesis#GO:0044085;organelle localization#GO:0051640;macroautophagy#GO:0016236;mitophagy#GO:0000423;autophagy of mitochondrion#GO:0000422;response to extracellular stimulus#GO:0009991;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;cellular component disassembly#GO:0022411;cellular response to starvation#GO:0009267;catabolic process#GO:0009056;mitochondrion organization#GO:0007005;autophagosome maturation#GO:0097352;cellular response to extracellular stimulus#GO:0031668;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;cellular component assembly#GO:0022607;cellular response to stimulus#GO:0051716;protein-containing complex disassembly#GO:0032984;cellular metabolic process#GO:0044237;cell communication#GO:0007154;cellular component organization#GO:0016043;response to nutrient levels#GO:0031667;cellular process#GO:0009987;organelle disassembly#GO:1903008;localization#GO:0051179;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to stress#GO:0006950;organelle organization#GO:0006996;cellular response to nutrient levels#GO:0031669;protein-containing complex organization#GO:0043933;response to starvation#GO:0042594;cellular response to external stimulus#GO:0071496;autophagosome assembly#GO:0000045;cellular response to stress#GO:0033554;autophagy#GO:0006914 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;phosphatidylinositol 3-kinase complex#GO:0005942;transferase complex#GO:1990234;vacuole#GO:0005773;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;phosphatidylinositol 3-kinase complex, class III#GO:0035032;intracellular organelle#GO:0043229;autophagosome#GO:0005776;transferase complex, transferring phosphorus-containing groups#GO:0061695;extrinsic component of membrane#GO:0019898;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;phagophore assembly site#GO:0000407;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG66029|UniProtKB=T1FYG0 T1FYG0 20213858 PTHR43053:SF4 GLYCOSIDASE FAMILY 31 MYOGENESIS-REGULATING GLYCOSIDASE glucosidase#PC00108 HELRO|EnsemblGenome=HelroG159832|UniProtKB=T1EPG4 T1EPG4 20198464 PTHR12242:SF45 OS02G0130600 PROTEIN-RELATED MARVEL DOMAIN-CONTAINING PROTEIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG163491|UniProtKB=T1EU46 T1EU46 20200096 PTHR11533:SF301 PROTEASE M1 ZINC METALLOPROTEASE AMINOPEPTIDASE metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;amide binding#GO:0033218;metal ion binding#GO:0046872;peptidase activity#GO:0008233;metalloaminopeptidase activity#GO:0070006;cation binding#GO:0043169;peptide binding#GO:0042277;hydrolase activity#GO:0016787;aminopeptidase activity#GO:0004177;exopeptidase activity#GO:0008238;ion binding#GO:0043167;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;peptide catabolic process#GO:0043171;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;membrane#GO:0016020;extracellular region#GO:0005576;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG153389|UniProtKB=T1EL64 T1EL64 20197314 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG154744|UniProtKB=T1ELF9 T1ELF9 20197409 PTHR44942:SF4 METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG123161|UniProtKB=T1EGX1 T1EGX1 20195821 PTHR16557:SF2 ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED NUCLEIC ACID DIOXYGENASE ALKBH1 ferrous iron binding#GO:0008198;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;catalytic activity, acting on a nucleic acid#GO:0140640;metal ion binding#GO:0046872;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;cation binding#GO:0043169;catalytic activity, acting on RNA#GO:0140098;demethylase activity#GO:0032451;iron ion binding#GO:0005506;dioxygenase activity#GO:0051213;catalytic activity, acting on DNA#GO:0140097;ion binding#GO:0043167 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;DNA modification#GO:0006304;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;DNA demethylation#GO:0080111;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG116539|UniProtKB=T1EGF8 T1EGF8 20195660 PTHR10534:SF2 PYRIDOXAL KINASE PYRIDOXAL KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 cellular aromatic compound metabolic process#GO:0006725;organic hydroxy compound metabolic process#GO:1901615;heterocycle metabolic process#GO:0046483;organophosphate biosynthetic process#GO:0090407;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic hydroxy compound biosynthetic process#GO:1901617;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;heterocycle biosynthetic process#GO:0018130;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;pyridine-containing compound metabolic process#GO:0072524;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;small molecule biosynthetic process#GO:0044283;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 kinase#PC00137 Vitamin B6 metabolism#P02787>Pyridoxal kinase#P03244;Pyridoxal phosphate salvage pathway#P02770>Pyridoxal kinase#P03121;Pyridoxal phosphate salvage pathway#P02770>Pyridoxamine kinase#P03122 HELRO|EnsemblGenome=HelroG155705|UniProtKB=T1ELL0 T1ELL0 20197460 PTHR11624:SF96 DEHYDROGENASE RELATED PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;sulfur compound metabolic process#GO:0006790;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;amide metabolic process#GO:0043603;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;heterocycle metabolic process#GO:0046483;acyl-CoA metabolic process#GO:0006637;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;monocarboxylic acid metabolic process#GO:0032787;purine ribonucleotide metabolic process#GO:0009150;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;carboxylic acid metabolic process#GO:0019752;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG107672|UniProtKB=T1EEC2 T1EEC2 20194924 PTHR11347:SF219 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE, ISOFORM I hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric diester hydrolase activity#GO:0008081;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;cAMP-mediated signaling#GO:0019933;signaling#GO:0023052;cyclic-nucleotide-mediated signaling#GO:0019935 phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG145872|UniProtKB=T1EJN6 T1EJN6 20196786 PTHR24388:SF100 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 423 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG168133|UniProtKB=T1F074 T1F074 20202224 PTHR24193:SF121 ANKYRIN REPEAT PROTEIN ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D HELRO|EnsemblGenome=HelroG90186|UniProtKB=T1G7M0 T1G7M0 20217067 PTHR10680:SF36 PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE PEPTIDYL-ALPHA-HYDROXYGLYCINE ALPHA-AMIDATING LYASE 1 cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 oxygenase#PC00177 Vasopressin synthesis#P04395>Amidating Enzyme#P04599 HELRO|EnsemblGenome=HelroG189732|UniProtKB=T1FRB2 T1FRB2 20211359 PTHR23003:SF3 RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN FI21236P1-RELATED nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG194043|UniProtKB=T1FVL8 T1FVL8 20212864 PTHR12243:SF67 MADF DOMAIN TRANSCRIPTION FACTOR COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG182570|UniProtKB=T1FID4 T1FID4 20208583 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG84960|UniProtKB=T1G5R0 T1G5R0 20216407 PTHR11533:SF299 PROTEASE M1 ZINC METALLOPROTEASE AMINOPEPTIDASE metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;amide binding#GO:0033218;metal ion binding#GO:0046872;peptidase activity#GO:0008233;metalloaminopeptidase activity#GO:0070006;cation binding#GO:0043169;peptide binding#GO:0042277;hydrolase activity#GO:0016787;aminopeptidase activity#GO:0004177;exopeptidase activity#GO:0008238;ion binding#GO:0043167;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;peptide catabolic process#GO:0043171;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;membrane#GO:0016020;extracellular region#GO:0005576;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG69886|UniProtKB=T1FZZ3 T1FZZ3 20214391 PTHR46961:SF8 DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN DYNEIN AXONEMAL HEAVY CHAIN 7 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG180797|UniProtKB=T1FGA4 T1FGA4 20207853 PTHR24235:SF29 NEUROPEPTIDE Y RECEPTOR GH23382P G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG167331|UniProtKB=T1EZ97 T1EZ97 20201897 PTHR15217:SF0 WILMS' TUMOR 1-ASSOCIATING PROTEIN PRE-MRNA-SPLICING REGULATOR WTAP cellular aromatic compound metabolic process#GO:0006725;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;regulation of nitrogen compound metabolic process#GO:0051171;RNA modification#GO:0009451;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;regulation of mRNA processing#GO:0050684;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;mRNA modification#GO:0016556;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;primary metabolic process#GO:0044238;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;nucleic acid metabolic process#GO:0090304;macromolecule methylation#GO:0043414;methylation#GO:0032259;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;RNA methylation#GO:0001510;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of metabolic process#GO:0019222;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;regulation of cellular metabolic process#GO:0031323;regulation of mRNA metabolic process#GO:1903311 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG190497|UniProtKB=T1FS16 T1FS16 20211613 PTHR12960:SF0 GLE-1-RELATED MRNA EXPORT FACTOR GLE1 translation initiation factor binding#GO:0031369;small molecule binding#GO:0036094;binding#GO:0005488;protein binding#GO:0005515;lipid binding#GO:0008289;anion binding#GO:0043168;ion binding#GO:0043167;phospholipid binding#GO:0005543;alcohol binding#GO:0043178 poly(A)+ mRNA export from nucleus#GO:0016973;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;mRNA transport#GO:0051028;RNA localization#GO:0006403;localization#GO:0051179;organic substance transport#GO:0071702;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 envelope#GO:0031975;cytoplasm#GO:0005737;nuclear pore#GO:0005643;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG188729|UniProtKB=T1FQB0 T1FQB0 20211007 PTHR11223:SF3 EXPORTIN 1/5 EXPORTIN-5 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular localization#GO:0051641;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;RNA localization#GO:0006403;localization#GO:0051179;organic substance transport#GO:0071702;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG173115|UniProtKB=T1F6D9 T1F6D9 20204388 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG67463|UniProtKB=T1FZ12 T1FZ12 20214060 PTHR24082:SF473 NUCLEAR HORMONE RECEPTOR ECDYSONE-INDUCED PROTEIN 75B, ISOFORM B cis-regulatory region sequence-specific DNA binding#GO:0000987;signaling receptor activity#GO:0038023;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;signal transduction#GO:0007165;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of RNA metabolic process#GO:0051253;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;hormone-mediated signaling pathway#GO:0009755;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;positive regulation of biosynthetic process#GO:0009891;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of transcription by RNA polymerase II#GO:0000122;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;response to organic substance#GO:0010033;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;cellular response to endogenous stimulus#GO:0071495;negative regulation of biosynthetic process#GO:0009890;cellular response to chemical stimulus#GO:0070887;regulation of DNA-templated transcription#GO:0006355;cellular response to organic substance#GO:0071310;negative regulation of metabolic process#GO:0009892;cell communication#GO:0007154;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;negative regulation of nitrogen compound metabolic process#GO:0051172;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;negative regulation of macromolecule biosynthetic process#GO:0010558;response to hormone#GO:0009725;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;response to chemical#GO:0042221;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG162773|UniProtKB=T1ET44 T1ET44 20199744 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG123829|UniProtKB=T1EGZ2 T1EGZ2 20195842 PTHR23279:SF36 DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED DEFECTIVE PROBOSCIS EXTENSION RESPONSE 9, ISOFORM A cellular component organization or biogenesis#GO:0071840;synapse organization#GO:0050808;cellular component organization#GO:0016043;cellular process#GO:0009987;cell junction organization#GO:0034330 cell leading edge#GO:0031252;neuron projection#GO:0043005;leading edge membrane#GO:0031256;plasma membrane region#GO:0098590;cell projection membrane#GO:0031253;cell projection#GO:0042995;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG82866|UniProtKB=T1G4X6 T1G4X6 20216124 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-LIKE 1 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;localization#GO:0051179;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 membrane protein complex#GO:0098796;synapse#GO:0045202;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron projection#GO:0043005;transmembrane transporter complex#GO:1902495;cell projection#GO:0042995;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HELRO|EnsemblGenome=HelroG191971|UniProtKB=T1FTG9 T1FTG9 20212116 PTHR33494:SF1 OS02G0793800 PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG107485|UniProtKB=T1EEA8 T1EEA8 20194910 PTHR43806:SF14 PEPTIDASE S8 TRIPEPTIDYL-PEPTIDASE 2 serine-type endopeptidase activity#GO:0004252;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG166528|UniProtKB=T1EY76 T1EY76 20201526 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG82909|UniProtKB=T1G4Y0 T1G4Y0 20216128 PTHR24347:SF454 SERINE/THREONINE-PROTEIN KINASE PHOSPHORYLASE KINASE non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716 HELRO|EnsemblGenome=HelroG158397|UniProtKB=T1EMR3 T1EMR3 20197863 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG70925|UniProtKB=T1G0E4 T1G0E4 20214542 PTHR46712:SF1 PHOSPHATIDYLGLYCEROPHOSPHATASE AND PROTEIN-TYROSINE PHOSPHATASE 1 PHOSPHATIDYLGLYCEROPHOSPHATASE AND PROTEIN-TYROSINE PHOSPHATASE 1 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 HELRO|EnsemblGenome=HelroG77825|UniProtKB=T1G346 T1G346 20215494 PTHR46472:SF1 NUCLEOREDOXIN NUCLEOREDOXIN protein-disulfide reductase activity#GO:0015035;disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;antioxidant activity#GO:0016209;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of protein modification process#GO:0031399;regulation of protein metabolic process#GO:0051246;negative regulation of response to stimulus#GO:0048585;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of protein modification process#GO:0031400;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of protein ubiquitination#GO:0031397;regulation of Wnt signaling pathway#GO:0030111;negative regulation of macromolecule metabolic process#GO:0010605;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of cellular process#GO:0048523;negative regulation of cell communication#GO:0010648;regulation of metabolic process#GO:0019222 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG182180|UniProtKB=T1FHV8 T1FHV8 20208407 PTHR13723:SF313 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;cellular component organization#GO:0016043;cellular process#GO:0009987;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG178828|UniProtKB=T1FDT0 T1FDT0 20206979 PTHR10334:SF590 CYSTEINE-RICH SECRETORY PROTEIN-RELATED SCP DOMAIN-CONTAINING PROTEIN extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG191249|UniProtKB=T1FSS7 T1FSS7 20211874 PTHR46380:SF2 CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1 CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG76015|UniProtKB=T1G2E0 T1G2E0 20215238 PTHR12406:SF41 CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED BRUMMER, ISOFORM B-RELATED hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824;triglyceride lipase activity#GO:0004806 lipid metabolic process#GO:0006629;triglyceride metabolic process#GO:0006641;neutral lipid catabolic process#GO:0046461;cellular metabolic process#GO:0044237;homeostatic process#GO:0042592;glycerolipid catabolic process#GO:0046503;lipid catabolic process#GO:0016042;triglyceride catabolic process#GO:0019433;chemical homeostasis#GO:0048878;cellular process#GO:0009987;acylglycerol metabolic process#GO:0006639;primary metabolic process#GO:0044238;acylglycerol catabolic process#GO:0046464;neutral lipid metabolic process#GO:0006638;glycerolipid metabolic process#GO:0046486;lipid homeostasis#GO:0055088;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;lipid droplet#GO:0005811;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 phospholipase#PC00186 HELRO|EnsemblGenome=HelroG62096|UniProtKB=T1FWV7 T1FWV7 20213305 PTHR10155:SF0 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT SUPPRESSOR OF CYTOKINE SIGNALING AT 36E, ISOFORM D kinase modulator#PC00140 Interferon-gamma signaling pathway#P00035>SOCS#P00956 HELRO|EnsemblGenome=HelroG172843|UniProtKB=T1F602 T1F602 20204251 PTHR22763:SF190 RING ZINC FINGER PROTEIN RING FINGER PROTEIN 24 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG120472|UniProtKB=T1EGQ0 T1EGQ0 20195750 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG179002|UniProtKB=T1FE14 T1FE14 20207063 PTHR31395:SF26 SHISA STANLEY-CUP scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG66479|UniProtKB=T1FYL8 T1FYL8 20213916 PTHR16017:SF0 GASTRULATION DEFECTIVE PROTEIN 1-RELATED WD REPEAT-CONTAINING PROTEIN 70 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;site of DNA damage#GO:0090734;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;site of double-strand break#GO:0035861;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG75396|UniProtKB=T1G246 T1G246 20215144 PTHR13134:SF3 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;vesicle tethering complex#GO:0099023;TRAPP complex#GO:0030008;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG188483|UniProtKB=T1FQ15 T1FQ15 20210912 PTHR45617:SF169 LEUCINE RICH REPEAT FAMILY PROTEIN LRRCT DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG174126|UniProtKB=T1F7N6 T1F7N6 20204835 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG160318|UniProtKB=T1EQ32 T1EQ32 20198682 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG112743|UniProtKB=T1EFL8 T1EFL8 20195370 PTHR46223:SF3 HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H HISTONE-LYSINE N-METHYLTRANSFERASE SET-23 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG155972|UniProtKB=T1ELQ2 T1ELQ2 20197502 PTHR46021:SF2 ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1 nucleoside-triphosphatase regulator activity#GO:0060589;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;small molecule binding#GO:0036094;binding#GO:0005488;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047;lipid binding#GO:0008289;anion binding#GO:0043168;phosphatidylinositol binding#GO:0035091;ion binding#GO:0043167;phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981;enzyme regulator activity#GO:0030234 biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;regulation of GTPase activity#GO:0043087;regulation of molecular function#GO:0065009 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG158636|UniProtKB=T1EN21 T1EN21 20197971 PTHR47510:SF3 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167749|UniProtKB=T1EZR1 T1EZR1 20202061 PTHR46601:SF1 ULP_PROTEASE DOMAIN-CONTAINING PROTEIN ADF-H DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185844|UniProtKB=T1FND0 T1FND0 20210327 PTHR45827:SF1 SORTING NEXIN SORTING NEXIN lipid binding#GO:0008289;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;binding#GO:0005488 endosomal transport#GO:0016197;cellular localization#GO:0051641;membrane organization#GO:0061024;plasma membrane organization#GO:0007009;transport#GO:0006810;endocytosis#GO:0006897;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;import into cell#GO:0098657 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG94235|UniProtKB=T1G8Z6 T1G8Z6 20217543 PTHR31624:SF4 UPF0472 PROTEIN C16ORF72 CHROMOSOME 16 OPEN READING FRAME 72 HELRO|EnsemblGenome=HelroG181717|UniProtKB=T1FH91 T1FH91 20208190 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189299|UniProtKB=T1FQX7 T1FQX7 20211224 PTHR12553:SF49 ZINC PHOSPHODIESTERASE ELAC PROTEIN 2 ZINC PHOSPHODIESTERASE ELAC PROTEIN 2 catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;mitochondrial RNA metabolic process#GO:0000959;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;mitochondrial gene expression#GO:0140053;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;mitochondrial RNA processing#GO:0000963;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;tRNA 3'-end processing#GO:0042780;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 phosphodiesterase#PC00185;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG183438|UniProtKB=T1FJN4 T1FJN4 20209033 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG92366|UniProtKB=T1G8F1 T1G8F1 20217348 PTHR24083:SF54 NUCLEAR HORMONE RECEPTOR NUCLEAR HORMONE RECEPTOR HR78 cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;signaling receptor activity#GO:0038023;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG185473|UniProtKB=T1FMV1 T1FMV1 20210150 PTHR43313:SF50 SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C GH26015P catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 lipid metabolic process#GO:0006629;steroid metabolic process#GO:0008202;organic cyclic compound metabolic process#GO:1901360;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG186957|UniProtKB=T1FP48 T1FP48 20210595 PTHR11627:SF80 FRUCTOSE-BISPHOSPHATE ALDOLASE FRUCTOSE-BISPHOSPHATE ALDOLASE-RELATED aldolase#PC00044;lyase#PC00144 Glycolysis#P00024>Aldolase#P00679;Fructose galactose metabolism#P02744>Fructose bisphosphate aldolase#P02959 HELRO|EnsemblGenome=HelroG113813|UniProtKB=T1EFX1 T1EFX1 20195473 PTHR43311:SF2 GLUTAMATE--TRNA LIGASE GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 Heme biosynthesis#P02746>Glutamyl-tRNA-synthetase#P02977 HELRO|EnsemblGenome=HelroG62236|UniProtKB=T1FWX5 T1FWX5 20213323 PTHR11216:SF31 EH DOMAIN AT21416P localization#GO:0051179;endosomal transport#GO:0016197;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;endocytosis#GO:0006897;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;cellular process#GO:0009987;import into cell#GO:0098657 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG72339|UniProtKB=T1G0Y6 T1G0Y6 20214734 PTHR11040:SF140 ZINC/IRON TRANSPORTER ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;transition metal ion transport#GO:0000041;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG133578|UniProtKB=T1EI15 T1EI15 20196215 PTHR24416:SF489 TYROSINE-PROTEIN KINASE RECEPTOR PROTEIN KINASE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG75183|UniProtKB=T1G223 T1G223 20215121 PTHR46172:SF1 DNA POLYMERASE EPSILON SUBUNIT 3 DNA POLYMERASE EPSILON SUBUNIT 3 nucleic acid binding#GO:0003676;protein-containing complex binding#GO:0044877;chromatin DNA binding#GO:0031490;chromatin binding#GO:0003682;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;protein-DNA complex organization#GO:0071824;heterochromatin formation#GO:0031507;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;DNA-templated DNA replication#GO:0006261;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;negative regulation of gene expression, epigenetic#GO:0045814;epigenetic regulation of gene expression#GO:0040029;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;heterochromatin organization#GO:0070828;response to stress#GO:0006950;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;chromatin organization#GO:0006325;cellular response to stress#GO:0033554;chromatin remodeling#GO:0006338;DNA replication#GO:0006260;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;DNA strand elongation involved in DNA replication#GO:0006271;regulation of cellular metabolic process#GO:0031323;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;chromatin#GO:0000785;transferase complex#GO:1990234;epsilon DNA polymerase complex#GO:0008622;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;DNA polymerase complex#GO:0042575;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG175630|UniProtKB=T1F9G0 T1F9G0 20205459 PTHR12021:SF26 THYMOSIN BETA THYMOSIN BETA cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;actin binding#GO:0003779;binding#GO:0005488;actin monomer binding#GO:0003785 negative regulation of protein polymerization#GO:0032272;cellular localization#GO:0051641;negative regulation of biological process#GO:0048519;macromolecule localization#GO:0033036;regulation of locomotion#GO:0040012;regulation of cellular component organization#GO:0051128;regulation of actin polymerization or depolymerization#GO:0008064;regulation of biological process#GO:0050789;regulation of cytoskeleton organization#GO:0051493;regulation of protein-containing complex assembly#GO:0043254;regulation of cell migration#GO:0030334;regulation of biological quality#GO:0065008;regulation of cellular component biogenesis#GO:0044087;negative regulation of organelle organization#GO:0010639;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament-based process#GO:0032970;negative regulation of cellular component organization#GO:0051129;regulation of protein polymerization#GO:0032271;negative regulation of cellular process#GO:0048523;regulation of anatomical structure size#GO:0090066;regulation of cell motility#GO:2000145;regulation of actin filament length#GO:0030832;regulation of organelle organization#GO:0033043;regulation of actin filament organization#GO:0110053;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of actin filament polymerization#GO:0030833;regulation of cellular component size#GO:0032535;protein localization#GO:0008104;negative regulation of supramolecular fiber organization#GO:1902904;regulation of supramolecular fiber organization#GO:1902903;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;cellular macromolecule localization#GO:0070727;maintenance of location#GO:0051235;regulation of cellular process#GO:0050794;negative regulation of actin filament polymerization#GO:0030837;maintenance of location in cell#GO:0051651;biological regulation#GO:0065007;negative regulation of protein-containing complex assembly#GO:0031333;negative regulation of cytoskeleton organization#GO:0051494 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG107242|UniProtKB=T1EE90 T1EE90 20194892 PTHR46395:SF1 ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1 ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1 nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of endocytosis#GO:0030100;regulation of transport#GO:0051049;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;regulation of signaling#GO:0023051;biological regulation#GO:0065007;regulation of localization#GO:0032879;regulation of cellular component organization#GO:0051128;regulation of intracellular signal transduction#GO:1902531;regulation of vesicle-mediated transport#GO:0060627;regulation of small GTPase mediated signal transduction#GO:0051056 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 GTPase-activating protein#PC00257 Integrin signalling pathway#P00034>ASAP1#P00909 HELRO|EnsemblGenome=HelroG158598|UniProtKB=T1EN01 T1EN01 20197951 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG92864|UniProtKB=T1G8M4 T1G8M4 20217421 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG162499|UniProtKB=T1ESR3 T1ESR3 20199613 PTHR47160:SF8 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG181625|UniProtKB=T1FH67 T1FH67 20208166 PTHR23107:SF34 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN HTH LA-TYPE RNA-BINDING DOMAIN-CONTAINING PROTEIN transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG180684|UniProtKB=T1FG60 T1FG60 20207809 PTHR11243:SF23 GROWTH FACTOR RECEPTOR-BOUND PROTEIN LD06925P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG189042|UniProtKB=T1FQL1 T1FQL1 20211108 PTHR15751:SF12 TRAFFICKING KINESIN-BINDING PROTEIN TRAFFICKING KINESIN-BINDING PROTEIN MILT cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;myosin binding#GO:0017022;binding#GO:0005488 vesicle transport along microtubule#GO:0047496;cellular localization#GO:0051641;organelle localization#GO:0051640;macromolecule localization#GO:0033036;vesicle localization#GO:0051648;transport#GO:0006810;microtubule-based movement#GO:0007018;protein targeting#GO:0006605;cellular component organization#GO:0016043;cellular process#GO:0009987;transport along microtubule#GO:0010970;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;microtubule-based transport#GO:0099111;cellular macromolecule localization#GO:0070727;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;organelle organization#GO:0006996;establishment of vesicle localization#GO:0051650;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;mitochondrion organization#GO:0007005;establishment of organelle localization#GO:0051656;organelle transport along microtubule#GO:0072384;vesicle cytoskeletal trafficking#GO:0099518 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG159526|UniProtKB=T1EP47 T1EP47 20198347 PTHR11616:SF240 SODIUM/CHLORIDE DEPENDENT TRANSPORTER BLOATED TUBULES, ISOFORM B-RELATED localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;nitrogen compound transport#GO:0071705;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG185973|UniProtKB=T1FNI1 T1FNI1 20210378 PTHR24067:SF254 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2-17 KDA ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;macromolecule modification#GO:0043412;protein catabolic process#GO:0030163;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;nucleobase-containing compound metabolic process#GO:0006139;modification-dependent macromolecule catabolic process#GO:0043632;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;cellular response to stimulus#GO:0051716;protein ubiquitination#GO:0016567;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation or removal#GO:0070647;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E2#P01491 HELRO|EnsemblGenome=HelroG181074|UniProtKB=T1FGL0 T1FGL0 20207959 PTHR13217:SF11 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 5 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052;Rho protein signal transduction#GO:0007266 HELRO|EnsemblGenome=HelroG182789|UniProtKB=T1FIQ7 T1FIQ7 20208706 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG191179|UniProtKB=T1FSP8 T1FSP8 20211845 PTHR45716:SF2 BITESIZE, ISOFORM I BITESIZE, ISOFORM I protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 localization#GO:0051179;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;export from cell#GO:0140352;secretion by cell#GO:0032940 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG146879|UniProtKB=T1EJV3 T1EJV3 20196853 PTHR11829:SF343 FORKHEAD BOX PROTEIN FORK-HEAD DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;anatomical structure morphogenesis#GO:0009653;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG79024|UniProtKB=T1G3I7 T1G3I7 20215635 PTHR23055:SF60 CALCIUM BINDING PROTEINS CALAXIN cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG188870|UniProtKB=T1FQF3 T1FQF3 20211050 PTHR34529:SF1 AP-1 COMPLEX-ASSOCIATED REGULATORY PROTEIN AP-1 COMPLEX-ASSOCIATED REGULATORY PROTEIN HELRO|EnsemblGenome=HelroG185511|UniProtKB=T1FMX0 T1FMX0 20210169 PTHR47979:SF33 DRAB11-RELATED DRAB11 GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;anion binding#GO:0043168;ion binding#GO:0043167 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;transport#GO:0006810 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG101626|UniProtKB=T1ED59 T1ED59 20194511 PTHR45762:SF3 ZINC FINGER RNA-BINDING PROTEIN ZINC-FINGER PROTEIN AT 72D, ISOFORM B RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG80090|UniProtKB=T1G3X6 T1G3X6 20215774 PTHR24416:SF564 TYROSINE-PROTEIN KINASE RECEPTOR MACROPHAGE-STIMULATING PROTEIN RECEPTOR signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;nervous system development#GO:0007399;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;system development#GO:0048731;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cell motility#GO:0048870;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;cell migration#GO:0016477;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG86367|UniProtKB=T1G6B3 T1G6B3 20216610 PTHR10799:SF973 SNF2/RAD54 HELICASE FAMILY ATP-DEPENDENT HELICASE BRM ATP-dependent activity, acting on DNA#GO:0008094;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on DNA#GO:0140097 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA helicase#PC00011;DNA metabolism protein#PC00009 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG63303|UniProtKB=T1FXD8 T1FXD8 20213486 PTHR24356:SF163 SERINE/THREONINE-PROTEIN KINASE 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PDK1#P00831;Ras Pathway#P04393>PDK#P04555;CCKR signaling map#P06959>PDPK1#P07162;PI3 kinase pathway#P00048>PDK1 ACT#P01190;PI3 kinase pathway#P00048>PDK1#P01196;p53 pathway feedback loops 2#P04398>PDK1/2#P04656;p53 pathway#P00059>PDK1/2#P04616;Interleukin signaling pathway#P00036>PDK1/2#P00985;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PDK1/2#P00903;PDGF signaling pathway#P00047>PDK1/2#P01164;PI3 kinase pathway#P00048>P110ACT#P01177 HELRO|EnsemblGenome=HelroG161865|UniProtKB=T1ERZ2 T1ERZ2 20199342 PTHR15730:SF5 EXPERIMENTAL AUTOIMMUNE PROSTATITIS ANTIGEN 2-RELATED SI:CH211-210B2.2-RELATED HELRO|EnsemblGenome=HelroG176143|UniProtKB=T1FA71 T1FA71 20205720 PTHR33244:SF3 INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED PEPTIDASE A2 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG103256|UniProtKB=T1EDF2 T1EDF2 20194604 PTHR23142:SF1 PRE-MRNA-SPLICING FACTOR 38A-RELATED PRE-MRNA-SPLICING FACTOR 38A ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;precatalytic spliceosome#GO:0071011;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG162746|UniProtKB=T1ET28 T1ET28 20199728 PTHR10032:SF271 ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS RH12261P-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG97732|UniProtKB=T1G9I7 T1G9I7 20217734 PTHR23147:SF22 SERINE/ARGININE RICH SPLICING FACTOR SERINE_ARGININE-RICH SPLICING FACTOR 2 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;nuclear speck#GO:0016607;organelle#GO:0043226;nuclear body#GO:0016604;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG63267|UniProtKB=T1FXD1 T1FXD1 20213479 PTHR11208:SF125 RNA-BINDING PROTEIN RELATED KH DOMAIN-CONTAINING RNA-BINDING PROTEIN QKI nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of RNA splicing#GO:0043484;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of mRNA processing#GO:0050684;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;regulation of mRNA metabolic process#GO:1903311 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG112528|UniProtKB=T1EFK5 T1EFK5 20195357 PTHR21329:SF3 PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;phospholipid biosynthetic process#GO:0008654;macromolecule modification#GO:0043412;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycolipid metabolic process#GO:0006664;protein modification process#GO:0036211;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;glycerolipid biosynthetic process#GO:0045017;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;organic substance biosynthetic process#GO:1901576;liposaccharide metabolic process#GO:1903509;cellular process#GO:0009987;GPI anchor metabolic process#GO:0006505;membrane lipid biosynthetic process#GO:0046467;lipoprotein biosynthetic process#GO:0042158;primary metabolic process#GO:0044238;GPI anchor biosynthetic process#GO:0006506;carbohydrate derivative biosynthetic process#GO:1901137;membrane lipid metabolic process#GO:0006643;glycerophospholipid biosynthetic process#GO:0046474;glycolipid biosynthetic process#GO:0009247;organophosphate metabolic process#GO:0019637;lipoprotein metabolic process#GO:0042157;cellular lipid metabolic process#GO:0044255 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG191221|UniProtKB=T1FSR4 T1FSR4 20211861 PTHR13491:SF0 ZCCHC10 PROTEIN ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10 HELRO|EnsemblGenome=HelroG86044|UniProtKB=T1G664 T1G664 20216561 PTHR11800:SF2 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;RNA polymerase activity#GO:0097747;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388;General transcription regulation#P00023>RNA Polymerase II#P00660 HELRO|EnsemblGenome=HelroG134508|UniProtKB=T1EI50 T1EI50 20196250 PTHR11409:SF39 ADENOSINE DEAMINASE ADENOSINE DEAMINASE 2 hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;adenosine deaminase activity#GO:0004000;deaminase activity#GO:0019239;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;nucleoside metabolic process#GO:0009116;glycosyl compound catabolic process#GO:1901658;carbohydrate derivative metabolic process#GO:1901135;heterocycle catabolic process#GO:0046700;organonitrogen compound catabolic process#GO:1901565;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase metabolic process#GO:0009112;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;purine-containing compound catabolic process#GO:0072523;organic cyclic compound metabolic process#GO:1901360;purine nucleoside metabolic process#GO:0042278;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;purine-containing compound metabolic process#GO:0072521;catabolic process#GO:0009056;nucleoside catabolic process#GO:0009164;organic substance catabolic process#GO:1901575;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;carbohydrate derivative catabolic process#GO:1901136;purine nucleobase metabolic process#GO:0006144;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;purine nucleoside catabolic process#GO:0006152;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;aromatic compound catabolic process#GO:0019439;nucleobase-containing compound biosynthetic process#GO:0034654;small molecule catabolic process#GO:0044282;nucleobase-containing small molecule catabolic process#GO:0034656;adenosine metabolic process#GO:0046085;organic cyclic compound catabolic process#GO:1901361;aromatic compound biosynthetic process#GO:0019438;small molecule biosynthetic process#GO:0044283;nucleobase-containing compound catabolic process#GO:0034655;glycosyl compound metabolic process#GO:1901657;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 deaminase#PC00088;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG177479|UniProtKB=T1FBR6 T1FBR6 20206265 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77987|UniProtKB=T1G361 T1G361 20215509 PTHR11681:SF5 NEUROPHYSIN ISOTOCIN neuropeptide hormone activity#GO:0005184;molecular function activator activity#GO:0140677;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;protein binding#GO:0005515;hormone activity#GO:0005179;signaling receptor binding#GO:0005102 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;extracellular region#GO:0005576;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;organelle#GO:0043226;secretory vesicle#GO:0099503;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 neuropeptide#PC00162;peptide hormone#PC00179 Opioid prodynorphin pathway#P05916>provasopressin#P05999;Opioid prodynorphin pathway#P05916>prepropressophysin#G06050;Vasopressin synthesis#P04395>Pro-Vasopressin#P04598;Vasopressin synthesis#P04395>Signal Peptide#P04597;Opioid prodynorphin pathway#P05916>vasopressin#P06000;Vasopressin synthesis#P04395>Vasopressin#P04590;Opioid prodynorphin pathway#P05916>prepropressophysin#G06048;Vasopressin synthesis#P04395>Pro-Neurophysin#P04591;Vasopressin synthesis#P04395>Glycopeptide#P04593;Vasopressin synthesis#P04395>Pro2-Vasopressin#P04595;Vasopressin synthesis#P04395>Neurophysin#P04594 HELRO|EnsemblGenome=HelroG99505|UniProtKB=T1G9T1 T1G9T1 20217827 PTHR24409:SF295 ZINC FINGER PROTEIN 142 AZ2-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG162182|UniProtKB=T1ESC0 T1ESC0 20199470 PTHR15572:SF0 GLIOMA TUMOR SUPPRESSOR CANDIDATE REGION GENE 1 GLUTAMINE-RICH PROTEIN-RELATED positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;ATPase complex#GO:1904949;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;SWI/SNF complex#GO:0016514;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG111918|UniProtKB=T1EFF8 T1EFF8 20195310 PTHR10829:SF23 CORTACTIN AND DREBRIN CORTACTIN, ISOFORM A cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 regulation of anatomical structure size#GO:0090066;regulation of actin filament length#GO:0030832;regulation of organelle organization#GO:0033043;regulation of actin filament organization#GO:0110053;regulation of cellular component organization#GO:0051128;cell motility#GO:0048870;cellular component organization#GO:0016043;regulation of actin polymerization or depolymerization#GO:0008064;cellular process#GO:0009987;regulation of actin filament polymerization#GO:0030833;regulation of cellular component size#GO:0032535;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cytoskeleton organization#GO:0051493;regulation of protein-containing complex assembly#GO:0043254;regulation of biological quality#GO:0065008;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament-based process#GO:0032970;cell migration#GO:0016477;regulation of protein polymerization#GO:0032271 supramolecular complex#GO:0099080;cortical cytoskeleton#GO:0030863;supramolecular polymer#GO:0099081;cellular anatomical entity#GO:0110165;cell cortex#GO:0005938;cell periphery#GO:0071944;supramolecular fiber#GO:0099512;cortical actin cytoskeleton#GO:0030864;organelle#GO:0043226;actin filament#GO:0005884;membrane#GO:0016020;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;plasma membrane#GO:0005886;site of polarized growth#GO:0030427 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG178946|UniProtKB=T1FDX9 T1FDX9 20207028 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG105468|UniProtKB=T1EDV1 T1EDV1 20194753 PTHR46007:SF8 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 C2H2-TYPE DOMAIN-CONTAINING PROTEIN molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;protein binding#GO:0005515;transcription factor binding#GO:0008134 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG185020|UniProtKB=T1FMA5 T1FMA5 20209954 PTHR10351:SF23 TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER TRANSCRIPTION FACTOR BTF3 cytoplasm#GO:0005737;cytosol#GO:0005829;protein-containing complex#GO:0032991;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG71833|UniProtKB=T1G0S1 T1G0S1 20214669 PTHR16517:SF7 TUBBY-RELATED PROTEIN KING TUBBY scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG169856|UniProtKB=T1F2D6 T1F2D6 20202986 PTHR23040:SF1 FAMILY NOT NAMED OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 4 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG186030|UniProtKB=T1FNK3 T1FNK3 20210400 PTHR20852:SF57 GLUTAMINE SYNTHETASE GLUTAMINE SYNTHETASE 2 CYTOPLASMIC ligase activity#GO:0016874;catalytic activity#GO:0003824 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;proteinogenic amino acid biosynthetic process#GO:0170038;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;alpha-amino acid biosynthetic process#GO:1901607;nitrogen compound metabolic process#GO:0006807;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;small molecule biosynthetic process#GO:0044283;L-amino acid biosynthetic process#GO:0170034;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 Glutamine glutamate conversion#P02745>Glutamine synthase#P04483;Glutamine glutamate conversion#P02745>Glutamine synthetase#P02968 HELRO|EnsemblGenome=HelroG186207|UniProtKB=T1FNT5 T1FNT5 20210482 PTHR10683:SF18 TRANSALDOLASE TRANSALDOLASE cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 aldolase#PC00044;lyase#PC00144 Pentose phosphate pathway#P02762>Transaldolase#P03081 HELRO|EnsemblGenome=HelroG153365|UniProtKB=T1EL50 T1EL50 20197305 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194220|UniProtKB=T1FVT8 T1FVT8 20212934 PTHR11139:SF119 ATAXIA TELANGIECTASIA MUTATED ATM -RELATED SERINE_THREONINE-PROTEIN KINASE SMG1 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 negative regulation of cellular metabolic process#GO:0031324;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;negative regulation of biological process#GO:0048519;regulation of catabolic process#GO:0009894;regulation of autophagy#GO:0010506;negative regulation of cellular catabolic process#GO:0031330;regulation of macroautophagy#GO:0016241;negative regulation of metabolic process#GO:0009892;cell communication#GO:0007154;negative regulation of autophagy#GO:0010507;regulation of cellular catabolic process#GO:0031329;negative regulation of macroautophagy#GO:0016242;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;negative regulation of catabolic process#GO:0009895;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;intracellular signal transduction#GO:0035556;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;regulation of metabolic process#GO:0019222;TOR signaling#GO:0031929;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 EGF receptor signaling pathway#P00018>PI3K#P00557 HELRO|EnsemblGenome=HelroG157880|UniProtKB=T1EMH2 T1EMH2 20197772 PTHR23064:SF32 TROPONIN CALTRACTIN ICL1F cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG166240|UniProtKB=T1EXX7 T1EXX7 20201427 PTHR45894:SF1 RNA-BINDING PROTEIN 8A RNA-BINDING PROTEIN 8A nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG110109|UniProtKB=T1EEZ1 T1EEZ1 20195143 PTHR24253:SF185 TRANSMEMBRANE PROTEASE SERINE PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG86082|UniProtKB=T1G671 T1G671 20216568 PTHR10126:SF37 TATA-BOX BINDING PROTEIN TATA BOX-BINDING PROTEIN-LIKE 2 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;gene expression#GO:0010467;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;aromatic compound biosynthetic process#GO:0019438;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 RNA metabolism protein#PC00031;general transcription factor#PC00259 General transcription by RNA polymerase I#P00022>TBP#P00657;Transcription regulation by bZIP transcription factor#P00055>TBP#P01399 HELRO|EnsemblGenome=HelroG184551|UniProtKB=T1FLG4 T1FLG4 20209663 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG86178|UniProtKB=T1G681 T1G681 20216578 PTHR21255:SF65 T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN TCTEX1 DOMAIN-CONTAINING PROTEIN 2 protein binding#GO:0005515;binding#GO:0005488 microtubule-based movement#GO:0007018;cellular process#GO:0009987;microtubule-based process#GO:0007017 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;microtubule cytoskeleton#GO:0015630;dynein complex#GO:0030286;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic dynein complex#GO:0005868;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG142631|UniProtKB=T1EJ64 T1EJ64 20196614 PTHR22961:SF13 SER/THR PROTEIN KINASE-TRB TRIBBLES enzyme binding#GO:0019899;protein binding#GO:0005515;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;regulation of catabolic process#GO:0009894;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of proteasomal protein catabolic process#GO:1901800;regulation of protein catabolic process#GO:0042176;regulation of proteolysis involved in protein catabolic process#GO:1903050;regulation of catalytic activity#GO:0050790;positive regulation of proteolysis#GO:0045862;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;regulation of protein serine/threonine kinase activity#GO:0071900;regulation of MAP kinase activity#GO:0043405;positive regulation of biological process#GO:0048518;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;regulation of kinase activity#GO:0043549;regulation of protein kinase activity#GO:0045859;regulation of proteolysis#GO:0030162;positive regulation of proteolysis involved in protein catabolic process#GO:1903052;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;positive regulation of macromolecule metabolic process#GO:0010604;regulation of primary metabolic process#GO:0080090;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of protein metabolic process#GO:0051247;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of protein phosphorylation#GO:0001932;biological regulation#GO:0065007;positive regulation of catabolic process#GO:0009896;positive regulation of protein catabolic process#GO:0045732;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG165205|UniProtKB=T1EWF5 T1EWF5 20200905 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193220|UniProtKB=T1FUR6 T1FUR6 20212562 PTHR20338:SF7 NUCLEAR RESPIRATORY FACTOR 1 MISEXPRESSION SUPPRESSOR OF RAS 3, ISOFORM B sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG175332|UniProtKB=T1F955 T1F955 20205354 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG115575|UniProtKB=T1EG94 T1EG94 20195596 PTHR10666:SF438 UBIQUITIN POLYUBIQUITIN-C structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159;ubiquitin-like protein ligase binding#GO:0044389;enzyme binding#GO:0019899;protein binding#GO:0005515;ubiquitin protein ligase binding#GO:0031625 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;protein modification by small protein conjugation#GO:0032446;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytosolic ribosome#GO:0022626;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;membrane-bounded organelle#GO:0043227;small ribosomal subunit#GO:0015935;ribosome#GO:0005840 HELRO|EnsemblGenome=HelroG187533|UniProtKB=T1FPA4 T1FPA4 20210651 PTHR17583:SF0 PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4 PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular localization#GO:0051641;establishment of protein localization to vacuole#GO:0072666;macroautophagy#GO:0016236;macromolecule localization#GO:0033036;protein targeting to vacuole#GO:0006623;vacuolar transport#GO:0007034;transport#GO:0006810;protein localization to vacuole#GO:0072665;protein targeting#GO:0006605;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;late endosome to vacuole transport#GO:0045324;establishment of protein localization to organelle#GO:0072594;cellular metabolic process#GO:0044237;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;process utilizing autophagic mechanism#GO:0061919;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein transport#GO:0015031;catabolic process#GO:0009056;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365;autophagy#GO:0006914;metabolic process#GO:0008152;cellular catabolic process#GO:0044248 membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;phosphatidylinositol 3-kinase complex#GO:0005942;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle membrane contact site#GO:0044232;phosphatidylinositol 3-kinase complex, class III#GO:0035032;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;extrinsic component of membrane#GO:0019898;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;late endosome#GO:0005770 kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG140303|UniProtKB=T1EJ05 T1EJ05 20196555 PTHR24031:SF54 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX10-RELATED cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG173198|UniProtKB=T1F6J6 T1F6J6 20204445 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG167111|UniProtKB=T1EZ11 T1EZ11 20201811 PTHR46787:SF1 SYNDROMES PUTATIVE CHAPERONIN-RELATED MOLECULAR CHAPERONE MKKS cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;cilium assembly#GO:0060271;cell projection organization#GO:0030030;transport#GO:0006810;protein-containing complex assembly#GO:0065003;chaperone-mediated protein complex assembly#GO:0051131;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;localization#GO:0051179;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;plasma membrane bounded cell projection assembly#GO:0120031 microtubule organizing center#GO:0005815;non-motile cilium#GO:0097730;cluster of actin-based cell projections#GO:0098862;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;stereocilium bundle#GO:0032421;kinocilium#GO:0060091;neuron projection#GO:0043005;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929 chaperone#PC00072 HELRO|EnsemblGenome=HelroG182218|UniProtKB=T1FHY2 T1FHY2 20208431 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG177041|UniProtKB=T1FB62 T1FB62 20206061 PTHR12665:SF7 ORMDL PROTEINS ORM1-LIKE PROTEIN lipid metabolic process#GO:0006629;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;homeostatic process#GO:0042592;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;intracellular chemical homeostasis#GO:0055082;membrane lipid biosynthetic process#GO:0046467;sphingolipid metabolic process#GO:0006665;primary metabolic process#GO:0044238;ceramide metabolic process#GO:0006672;membrane lipid metabolic process#GO:0006643;nitrogen compound metabolic process#GO:0006807;lipid homeostasis#GO:0055088;cellular lipid metabolic process#GO:0044255;amide metabolic process#GO:0043603;sphingolipid biosynthetic process#GO:0030148;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;endoplasmic reticulum protein-containing complex#GO:0140534;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;catalytic complex#GO:1902494;transferase complex#GO:1990234;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG178982|UniProtKB=T1FE04 T1FE04 20207053 PTHR24253:SF176 TRANSMEMBRANE PROTEASE SERINE CORIN, ISOFORM B serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG173517|UniProtKB=T1F6X3 T1F6X3 20204572 PTHR46449:SF5 ZGC:158260 FAMILY WITH SEQUENCE SIMILARITY 47 MEMBER E positive regulation of gene expression#GO:0010628;cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;protein-DNA complex organization#GO:0071824;RNA metabolic process#GO:0016070;positive regulation of cellular metabolic process#GO:0031325;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;transcription initiation at RNA polymerase II promoter#GO:0006367;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;positive regulation of cellular biosynthetic process#GO:0031328;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;organic cyclic compound biosynthetic process#GO:1901362;epigenetic regulation of gene expression#GO:0040029;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;positive regulation of cellular process#GO:0048522;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;transcription by RNA polymerase II#GO:0006366;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;protein-DNA complex#GO:0032993;chromosome#GO:0005694;chromatin#GO:0000785;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG135400|UniProtKB=T1EI87 T1EI87 20196287 PTHR10828:SF17 M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25 PROTEIN-TYROSINE-PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 regulation of cell cycle G2/M phase transition#GO:1902749;mitotic cell cycle phase transition#GO:0044772;regulation of mitotic cell cycle phase transition#GO:1901990;cell cycle process#GO:0022402;regulation of cell cycle phase transition#GO:1901987;positive regulation of cell cycle#GO:0045787;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047;cell cycle phase transition#GO:0044770;positive regulation of cellular process#GO:0048522;regulation of cell cycle process#GO:0010564;regulation of biological process#GO:0050789;G2/M transition of mitotic cell cycle#GO:0000086;mitotic cell cycle#GO:0000278;regulation of meiotic cell cycle#GO:0051445;regulation of cellular process#GO:0050794;positive regulation of cell cycle process#GO:0090068;positive regulation of mitotic cell cycle#GO:0045931;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of G2/M transition of mitotic cell cycle#GO:0010389;positive regulation of biological process#GO:0048518;regulation of mitotic cell cycle#GO:0007346;cell cycle G2/M phase transition#GO:0044839 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG86224|UniProtKB=T1G687 T1G687 20216584 PTHR13809:SF48 GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA-RELATED heterotrimeric G-protein#PC00117;G-protein#PC00020 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Gbetagamma#P00836;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GIRK#P00743;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047 HELRO|EnsemblGenome=HelroG171971|UniProtKB=T1F4W7 T1F4W7 20203866 PTHR17985:SF8 SER/THR-RICH PROTEIN T10 IN DGCR REGION TRANSPORT AND GOLGI ORGANIZATION PROTEIN 2 HOMOLOG HELRO|EnsemblGenome=HelroG84522|UniProtKB=T1G5J6 T1G5J6 20216343 PTHR21107:SF2 CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19 CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;respiratory chain complex IV assembly#GO:0008535;mitochondrial respiratory chain complex assembly#GO:0033108;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;cytochrome complex assembly#GO:0017004;protein-containing complex assembly#GO:0065003;mitochondrial cytochrome c oxidase assembly#GO:0033617;mitochondrion organization#GO:0007005;cellular component organization#GO:0016043;cellular process#GO:0009987 envelope#GO:0031975;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;mitochondrial envelope#GO:0005740;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;mitochondrial intermembrane space#GO:0005758;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG104126|UniProtKB=T1EDJ7 T1EDJ7 20194649 PTHR22883:SF488 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular localization#GO:0051641;macromolecule localization#GO:0033036;macromolecule modification#GO:0043412;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;protein palmitoylation#GO:0018345;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;localization within membrane#GO:0051668;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein localization to membrane#GO:0072657;organonitrogen compound biosynthetic process#GO:1901566;protein targeting#GO:0006605;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;protein acylation#GO:0043543;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipoprotein biosynthetic process#GO:0042158;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;lipoprotein metabolic process#GO:0042157 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG189308|UniProtKB=T1FQY0 T1FQY0 20211227 PTHR14568:SF8 TRANSMEMBRANE SUPERFAMILY 6 MEMBER 1/2 EXPERA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG109524|UniProtKB=T1EEU4 T1EEU4 20195096 PTHR10663:SF342 GUANYL-NUCLEOTIDE EXCHANGE FACTOR FI21420P1 cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;organelle organization#GO:0006996 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG187239|UniProtKB=T1FP82 T1FP82 20210629 PTHR43380:SF1 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL oxoacid metabolic process#GO:0043436;branched-chain amino acid metabolic process#GO:0009081;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;amino acid catabolic process#GO:0009063;small molecule catabolic process#GO:0044282;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;cellular catabolic process#GO:0044248 dehydrogenase#PC00092;oxidoreductase#PC00176 Pyruvate metabolism#P02772>Pyruvate Dehydrogenase#P03133 HELRO|EnsemblGenome=HelroG81548|UniProtKB=T1G4F6 T1G4F6 20215954 PTHR12937:SF0 VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG protein-containing complex binding#GO:0044877;binding#GO:0005488 endosomal transport#GO:0016197;cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;protein catabolic process#GO:0030163;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;nitrogen compound transport#GO:0071705;organonitrogen compound catabolic process#GO:1901565;late endosome to vacuole transport#GO:0045324;protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043328;establishment of protein localization#GO:0045184;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;modification-dependent macromolecule catabolic process#GO:0043632;organic substance transport#GO:0071702;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein localization to organelle#GO:0033365;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;establishment of protein localization to vacuole#GO:0072666;modification-dependent protein catabolic process#GO:0019941;vacuolar transport#GO:0007034;macromolecule metabolic process#GO:0043170;protein localization to vacuole#GO:0072665;organonitrogen compound metabolic process#GO:1901564;establishment of protein localization to organelle#GO:0072594;vesicle-mediated transport#GO:0016192;multivesicular body sorting pathway#GO:0071985;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein localization#GO:0008104;ubiquitin-dependent protein catabolic process#GO:0006511;localization#GO:0051179;cellular macromolecule localization#GO:0070727;protein transport#GO:0015031;endosome transport via multivesicular body sorting pathway#GO:0032509;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endosome membrane#GO:0010008;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ESCRT I complex#GO:0000813;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cytoplasmic vesicle membrane#GO:0030659 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG188008|UniProtKB=T1FPJ5 T1FPJ5 20210742 PTHR15907:SF161 DUF614 FAMILY PROTEIN-RELATED PLAC8 FAMILY PROTEIN HELRO|EnsemblGenome=HelroG190684|UniProtKB=T1FS72 T1FS72 20211669 PTHR12329:SF5 BCL2-ASSOCIATED ATHANOGENE STARVIN, ISOFORM E nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;molecular function regulator activity#GO:0098772;nucleoside phosphate binding#GO:1901265;protein binding#GO:0005515;heterocyclic compound binding#GO:1901363;protein-folding chaperone binding#GO:0051087 biological regulation#GO:0065007;regulation of protein stability#GO:0031647;regulation of biological quality#GO:0065008;protein stabilization#GO:0050821 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG169858|UniProtKB=T1F2D7 T1F2D7 20202987 PTHR46154:SF4 FAMILY NOT NAMED UREA ACTIVE TRANSPORTER HELRO|EnsemblGenome=HelroG117017|UniProtKB=T1EGJ3 T1EGJ3 20195695 PTHR14958:SF29 POTASSIUM CHANNEL TETRAMERISATION DOMAIN CONTAINING PROTEIN INSOMNIAC, ISOFORM B cullin family protein binding#GO:0097602;protein binding#GO:0005515;binding#GO:0005488 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG157035|UniProtKB=T1EM50 T1EM50 20197650 PTHR12821:SF0 BYSTIN BYSTIN snoRNA binding#GO:0030515;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;preribosome, small subunit precursor#GO:0030688;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981 HELRO|EnsemblGenome=HelroG184487|UniProtKB=T1FLA9 T1FLA9 20209608 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG111560|UniProtKB=T1EFC5 T1EFC5 20195277 PTHR11452:SF83 ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE ALPHA-GALACTOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 carbohydrate derivative metabolic process#GO:1901135;glycosyl compound catabolic process#GO:1901658;carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;glycosyl compound metabolic process#GO:1901657;carbohydrate metabolic process#GO:0005975;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 galactosidase#PC00104;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG70034|UniProtKB=T1G017 T1G017 20214415 PTHR20935:SF0 PHOSPHOGLYCERATE MUTASE-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE PGAM5, MITOCHONDRIAL mutase#PC00160 HELRO|EnsemblGenome=HelroG89171|UniProtKB=T1G796 T1G796 20216943 PTHR18945:SF879 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission#GO:0007268;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 cell junction#GO:0030054;synapse#GO:0045202;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;neuron projection#GO:0043005 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG188913|UniProtKB=T1FQH1 T1FQH1 20211068 PTHR12747:SF0 ELONGATOR COMPLEX PROTEIN 1 ELONGATOR COMPLEX PROTEIN 1 tRNA binding#GO:0000049;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;tRNA wobble uridine modification#GO:0002098;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 elongator holoenzyme complex#GO:0033588;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 PDGF signaling pathway#P00047>Ikk#P01146 HELRO|EnsemblGenome=HelroG182433|UniProtKB=T1FI68 T1FI68 20208517 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG163616|UniProtKB=T1EUA2 T1EUA2 20200152 PTHR24365:SF530 TOLL-LIKE RECEPTOR MSTPROX-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;response to stress#GO:0006950;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;defense response#GO:0006952;signaling#GO:0023052;inflammatory response#GO:0006954 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG164215|UniProtKB=T1EV39 T1EV39 20200439 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159580|UniProtKB=T1EP68 T1EP68 20198368 PTHR31251:SF169 SQUAMOSA PROMOTER-BINDING-LIKE PROTEIN 4 SQUAMOSA PROMOTER-BINDING-LIKE PROTEIN 8 HELRO|EnsemblGenome=HelroG167939|UniProtKB=T1EZZ6 T1EZZ6 20202146 PTHR11081:SF70 FLAP ENDONUCLEASE FAMILY MEMBER FLAP ENDONUCLEASE GEN HOMOLOG 1 DNA endonuclease activity#GO:0004520;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824;endonuclease activity#GO:0004519;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097 DNA metabolism protein#PC00009;exodeoxyribonuclease#PC00098 HELRO|EnsemblGenome=HelroG179480|UniProtKB=T1FES0 T1FES0 20207319 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG75171|UniProtKB=T1G220 T1G220 20215118 PTHR11937:SF13 ACTIN ACTIN-RELATED PROTEIN 8 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;double-strand break repair#GO:0006302;regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA biosynthetic process#GO:2001141;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;regulation of DNA-templated transcription#GO:0006355;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;primary metabolic process#GO:0044238;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;regulation of cellular biosynthetic process#GO:0031326;response to stress#GO:0006950;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;cellular response to stress#GO:0033554;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;Ino80 complex#GO:0031011;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;chromatin#GO:0000785;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;INO80-type complex#GO:0097346;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 cytoskeletal protein#PC00085;actin and actin related protein#PC00039;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG191624|UniProtKB=T1FT52 T1FT52 20211999 PTHR15431:SF4 FGFR1 ONCOGENE PARTNER/LISH DOMAIN-CONTAINING PROTEIN PROTEIN TONNEAU 1B HELRO|EnsemblGenome=HelroG174537|UniProtKB=T1F884 T1F884 20205033 PTHR48043:SF145 EG:EG0003.4 PROTEIN-RELATED FI06409P-RELATED HELRO|EnsemblGenome=HelroG157894|UniProtKB=T1EMH4 T1EMH4 20197774 PTHR13861:SF2 VACUOLAR ATP SYNTHASE SUBUNIT F V-TYPE PROTON ATPASE SUBUNIT F cellular anatomical entity#GO:0110165;membrane#GO:0016020 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG177110|UniProtKB=T1FB86 T1FB86 20206085 PTHR22802:SF463 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG164645|UniProtKB=T1EVP0 T1EVP0 20200640 PTHR22761:SF10 CHARGED MULTIVESICULAR BODY PROTEIN GH13992P endosomal transport#GO:0016197;cellular localization#GO:0051641;membrane organization#GO:0061024;vacuolar transport#GO:0007034;transport#GO:0006810;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;vesicle-mediated transport#GO:0016192;late endosome to vacuole transport#GO:0045324;cellular component organization#GO:0016043;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;vesicle budding from membrane#GO:0006900;establishment of localization#GO:0051234;organelle organization#GO:0006996;endosome transport via multivesicular body sorting pathway#GO:0032509;establishment of localization in cell#GO:0051649;vesicle organization#GO:0016050;intracellular transport#GO:0046907 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;endosome membrane#GO:0010008;membrane#GO:0016020;side of membrane#GO:0098552;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG79262|UniProtKB=T1G3L8 T1G3L8 20215666 PTHR45810:SF9 HISTONE H3.2 HISTONE H3 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG156470|UniProtKB=T1ELX2 T1ELX2 20197572 PTHR10934:SF2 60S RIBOSOMAL PROTEIN L18 LARGE RIBOSOMAL SUBUNIT PROTEIN EL18 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG175374|UniProtKB=T1F974 T1F974 20205373 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161283|UniProtKB=T1ERA4 T1ERA4 20199104 PTHR23185:SF0 PROTEIN VIRILIZER HOMOLOG PROTEIN VIRILIZER HOMOLOG nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;cellular metabolic process#GO:0044237;mRNA modification#GO:0016556;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;methylation#GO:0032259;macromolecule methylation#GO:0043414;nitrogen compound metabolic process#GO:0006807;RNA methylation#GO:0001510;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;methyltransferase complex#GO:0034708;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;transferase complex#GO:1990234 HELRO|EnsemblGenome=HelroG194007|UniProtKB=T1FVK3 T1FVK3 20212849 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG82058|UniProtKB=T1G4M3 T1G4M3 20216021 PTHR21245:SF10 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN SYNCRIP, ISOFORM Q-RELATED nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG172391|UniProtKB=T1F589 T1F589 20203988 PTHR13491:SF0 ZCCHC10 PROTEIN ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10 HELRO|EnsemblGenome=HelroG166512|UniProtKB=T1EY71 T1EY71 20201521 PTHR10075:SF100 BASIGIN RELATED FASCICLIN-2 cell adhesion molecule binding#GO:0050839;cell-cell adhesion mediator activity#GO:0098632;protein binding#GO:0005515;binding#GO:0005488 neuron projection guidance#GO:0097485;cell recognition#GO:0008037;neurogenesis#GO:0022008;cell projection organization#GO:0030030;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;axonogenesis#GO:0007409;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156;cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cell morphogenesis#GO:0000902;cellular process#GO:0009987;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure development#GO:0048856;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;axon#GO:0030424 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG116156|UniProtKB=T1EGD4 T1EGD4 20195636 PTHR10629:SF52 CYTOSINE-SPECIFIC METHYLTRANSFERASE DNA (CYTOSINE-5)-METHYLTRANSFERASE 1 DNA methyltransferase#PC00013 HELRO|EnsemblGenome=HelroG184879|UniProtKB=T1FM44 T1FM44 20209893 PTHR12046:SF0 HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG193042|UniProtKB=T1FUK0 T1FUK0 20212496 PTHR46358:SF1 TONSOKU-LIKE PROTEIN TONSOKU-LIKE PROTEIN DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;double-strand break repair via homologous recombination#GO:0000724;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;response to stress#GO:0006950;nitrogen compound metabolic process#GO:0006807;recombinational repair#GO:0000725;DNA-templated DNA replication#GO:0006261;replication fork processing#GO:0031297;DNA replication#GO:0006260;cellular response to stress#GO:0033554;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;metabolic process#GO:0008152 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;chromosome#GO:0005694;nuclear replication fork#GO:0043596;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;replication fork#GO:0005657 HELRO|EnsemblGenome=HelroG185040|UniProtKB=T1FMB6 T1FMB6 20209965 PTHR31964:SF113 ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE SUPERFAMILY PROTEIN USPA DOMAIN-CONTAINING PROTEIN metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG188756|UniProtKB=T1FQC0 T1FQC0 20211017 PTHR14690:SF0 IQ MOTIF CONTAINING WITH AAA DOMAIN 1 IQ MOTIF CONTAINING WITH AAA DOMAIN 1 HELRO|EnsemblGenome=HelroG84503|UniProtKB=T1G5J3 T1G5J3 20216340 PTHR24346:SF51 MAP/MICROTUBULE AFFINITY-REGULATING KINASE PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 negative regulation of cellular metabolic process#GO:0031324;signal transduction#GO:0007165;negative regulation of biological process#GO:0048519;macromolecule modification#GO:0043412;protein modification process#GO:0036211;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;phosphorylation#GO:0016310;regulation of macromolecule biosynthetic process#GO:0010556;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;negative regulation of cellular process#GO:0048523;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular response to stimulus#GO:0051716;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;cell communication#GO:0007154;negative regulation of metabolic process#GO:0009892;cellular process#GO:0009987;primary metabolic process#GO:0044238;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG160219|UniProtKB=T1EPZ8 T1EPZ8 20198648 PTHR44826:SF3 SPORE COAT PROTEIN SP85 SPORE COAT PROTEIN SP85 HELRO|EnsemblGenome=HelroG179258|UniProtKB=T1FEG0 T1FEG0 20207209 PTHR34203:SF15 METHYLTRANSFERASE, FKBM FAMILY PROTEIN SLL1173 PROTEIN methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG185768|UniProtKB=T1FN96 T1FN96 20210294 PTHR19375:SF184 HEAT SHOCK PROTEIN 70KDA STRESS-70 PROTEIN, MITOCHONDRIAL Hsp70 family chaperone#PC00027 Parkinson disease#P00049>Hsp70#P01208 HELRO|EnsemblGenome=HelroG188408|UniProtKB=T1FPY7 T1FPY7 20210884 PTHR34009:SF2 PROTEIN STAR PROTEIN STAR localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;endosomal transport#GO:0016197;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987 bounding membrane of organelle#GO:0098588;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;late endosome membrane#GO:0031902;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;endosome membrane#GO:0010008;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle membrane#GO:0030659;endoplasmic reticulum#GO:0005783;late endosome#GO:0005770;plasma membrane#GO:0005886;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG160549|UniProtKB=T1EQE5 T1EQE5 20198795 PTHR10334:SF590 CYSTEINE-RICH SECRETORY PROTEIN-RELATED SCP DOMAIN-CONTAINING PROTEIN extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG194833|UniProtKB=T1FWG8 T1FWG8 20213163 PTHR24347:SF424 SERINE/THREONINE-PROTEIN KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein serine/threonine kinase activity#GO:0004674;protein binding#GO:0005515;calmodulin binding#GO:0005516;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191789|UniProtKB=T1FTB8 T1FTB8 20212065 PTHR45080:SF33 CONTACTIN 5 IG-LIKE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cellular component organization or biogenesis#GO:0071840;synapse organization#GO:0050808;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156;cell junction organization#GO:0034330;cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cellular process#GO:0009987 somatodendritic compartment#GO:0036477;cell body#GO:0044297;neuron projection#GO:0043005;neuronal cell body#GO:0043025;cell projection#GO:0042995;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;plasma membrane#GO:0005886;axon#GO:0030424 HELRO|EnsemblGenome=HelroG175868|UniProtKB=T1F9S9 T1F9S9 20205578 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG104183|UniProtKB=T1EDK2 T1EDK2 20194654 PTHR13817:SF73 TITIN FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN structural protein#PC00211 HELRO|EnsemblGenome=HelroG87802|UniProtKB=T1G6V6 T1G6V6 20216803 PTHR10146:SF14 PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG85304|UniProtKB=T1G5V2 T1G5V2 20216449 PTHR45617:SF170 LEUCINE RICH REPEAT FAMILY PROTEIN MIP14966P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG184565|UniProtKB=T1FLH6 T1FLH6 20209675 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157680|UniProtKB=T1EME5 T1EME5 20197745 PTHR23264:SF19 NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2 small molecule binding#GO:0036094;binding#GO:0005488;iron-sulfur cluster binding#GO:0051536 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;iron-sulfur cluster assembly#GO:0016226;cellular component organization#GO:0016043;cellular process#GO:0009987 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG157080|UniProtKB=T1EM60 T1EM60 20197660 PTHR28080:SF1 PEROXISOMAL BIOGENESIS FACTOR 3 PEROXISOMAL BIOGENESIS FACTOR 3 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 localization within membrane#GO:0051668;cellular localization#GO:0051641;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;transport#GO:0006810;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;cellular component organization#GO:0016043;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to membrane#GO:0090150;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;organelle organization#GO:0006996;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365;peroxisome organization#GO:0007031 bounding membrane of organelle#GO:0098588;peroxisomal membrane#GO:0005778;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;peroxisome#GO:0005777;microbody#GO:0042579;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG168642|UniProtKB=T1F0U1 T1F0U1 20202441 PTHR46896:SF3 SENTRIN-SPECIFIC PROTEASE FI06413P-RELATED cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG170932|UniProtKB=T1F3M0 T1F3M0 20203419 PTHR23107:SF39 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN SS18 N-TERMINAL DOMAIN-CONTAINING PROTEIN gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG84675|UniProtKB=T1G5L8 T1G5L8 20216365 PTHR21668:SF0 EIF-1A EUKARYOTIC TRANSLATION INITIATION FACTOR 4C nucleic acid binding#GO:0003676;translation regulator activity#GO:0045182;translation regulator activity, nucleic acid binding#GO:0090079;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation initiation factor activity#GO:0003743;translation factor activity, RNA binding#GO:0008135 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;translational initiation#GO:0006413;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG111102|UniProtKB=T1EF82 T1EF82 20195234 PTHR15276:SF0 H4 D10S170 PROTEIN-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN 6 HELRO|EnsemblGenome=HelroG97810|UniProtKB=T1G9J1 T1G9J1 20217738 PTHR12121:SF100 CARBON CATABOLITE REPRESSOR PROTEIN 4 POLY(A)-SPECIFIC RIBONUCLEASE catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787;3'-5'-RNA exonuclease activity#GO:0000175;exonuclease activity#GO:0004527;3'-5' exonuclease activity#GO:0008408;RNA nuclease activity#GO:0004540 mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG181816|UniProtKB=T1FHD3 T1FHD3 20208232 PTHR31697:SF2 INTEGRATOR COMPLEX SUBUNIT 5 INTEGRATOR COMPLEX SUBUNIT 5 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;snRNA metabolic process#GO:0016073;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;snRNA 3'-end processing#GO:0034472;snRNA processing#GO:0016180;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;integrator complex#GO:0032039 HELRO|EnsemblGenome=HelroG193864|UniProtKB=T1FVF4 T1FVF4 20212800 PTHR11947:SF20 PYRUVATE DEHYDROGENASE KINASE [3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE, MITOCHONDRIAL transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;regulation of metabolic process#GO:0019222;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG162228|UniProtKB=T1ESD8 T1ESD8 20199488 PTHR46181:SF3 MITOCHONDRIAL GLYCINE TRANSPORTER MITOCHONDRIAL GLYCINE TRANSPORTER transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;organic acid transmembrane transporter activity#GO:0005342;L-amino acid transmembrane transporter activity#GO:0015179;glycine transmembrane transporter activity#GO:0015187;organic anion transmembrane transporter activity#GO:0008514;amino acid transmembrane transporter activity#GO:0015171;neutral L-amino acid transmembrane transporter activity#GO:0015175;transporter activity#GO:0005215 neutral amino acid transport#GO:0015804;L-amino acid transport#GO:0015807;transmembrane transport#GO:0055085;organic anion transport#GO:0015711;amino acid transport#GO:0006865;organic acid transport#GO:0015849;transport#GO:0006810;nitrogen compound transport#GO:0071705;carboxylic acid transport#GO:0046942;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039;localization#GO:0051179;mitochondrial transport#GO:0006839;organic substance transport#GO:0071702;amino acid transmembrane transport#GO:0003333;establishment of localization#GO:0051234;L-alpha-amino acid transmembrane transport#GO:1902475;organic acid transmembrane transport#GO:1903825;glycine transport#GO:0015816;mitochondrial transmembrane transport#GO:1990542 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG184535|UniProtKB=T1FLF0 T1FLF0 20209649 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG183655|UniProtKB=T1FK01 T1FK01 20209150 PTHR25462:SF305 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG62623|UniProtKB=T1FX28 T1FX28 20213376 PTHR11571:SF224 GLUTATHIONE S-TRANSFERASE HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE glutathione transferase activity#GO:0004364;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824 sulfur compound metabolic process#GO:0006790;nitrogen compound metabolic process#GO:0006807;peptide metabolic process#GO:0006518;cellular modified amino acid metabolic process#GO:0006575;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular process#GO:0009987;glutathione metabolic process#GO:0006749;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG90686|UniProtKB=T1G7U5 T1G7U5 20217142 PTHR14614:SF39 HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG183791|UniProtKB=T1FK71 T1FK71 20209220 PTHR10417:SF15 GLUCOCORTICOID MODULATORY ELEMENT-BINDING PROTEIN STERILE ALPHA MOTIF DOMAIN-CONTAINING 11 HELRO|EnsemblGenome=HelroG160928|UniProtKB=T1EQV4 T1EQV4 20198954 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168416|UniProtKB=T1F0K3 T1F0K3 20202353 PTHR13808:SF1 CBP/P300-RELATED HISTONE ACETYLTRANSFERASE histone modifying activity#GO:0140993;nucleic acid binding#GO:0003676;acyltransferase activity#GO:0016746;peptide N-acetyltransferase activity#GO:0034212;binding#GO:0005488;catalytic activity#GO:0003824;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;N-acyltransferase activity#GO:0016410;histone acetyltransferase activity#GO:0004402;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;molecular adaptor activity#GO:0060090;N-acetyltransferase activity#GO:0008080;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;chromatin DNA binding#GO:0031490;transferase activity#GO:0016740;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;protein-containing complex binding#GO:0044877;catalytic activity, acting on a protein#GO:0140096 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of RNA metabolic process#GO:0051254;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;chromatin#GO:0000785;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;chromosome#GO:0005694 histone modifying enzyme#PC00261 DPP signaling pathway#P06213>NEJ#P06284;TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282;SCW signaling pathway#P06216>NEJ#P06328;GBB signaling pathway#P06214>NEJ#P06295;BMP/activin signaling pathway-drosophila#P06211>NEJ#P06246;p53 pathway#P00059>CBP#P04623;Wnt signaling pathway#P00057>CBP#P01448;Transcription regulation by bZIP transcription factor#P00055>CBP/P300#P01387;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CREB#P00713;DPP-SCW signaling pathway#P06212>NEJ#P06260;Huntington disease#P00029>CBP#P00777 HELRO|EnsemblGenome=HelroG194789|UniProtKB=T1FWE9 T1FWE9 20213144 PTHR22880:SF225 FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED protein binding#GO:0005515;histone binding#GO:0042393;binding#GO:0005488;modification-dependent protein binding#GO:0140030 protein-DNA complex organization#GO:0071824;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;cellular component organization#GO:0016043;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG189584|UniProtKB=T1FR63 T1FR63 20211310 PTHR14312:SF6 CREB/ATF BZIP TRANSCRIPTION FACTOR SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG194573|UniProtKB=T1FW75 T1FW75 20213071 PTHR11679:SF71 VESICLE PROTEIN SORTING-ASSOCIATED SEC1 FAMILY DOMAIN-CONTAINING PROTEIN 2 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG95115|UniProtKB=T1G946 T1G946 20217593 PTHR20920:SF5 RPE-SPONDIN SMB DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174883|UniProtKB=T1F8K6 T1F8K6 20205155 PTHR14596:SF72 ZINC FINGER PROTEIN ZINC FINGER PROTEIN MSN2-RELATED cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to nutrient levels#GO:0031667;response to extracellular stimulus#GO:0009991;response to stress#GO:0006950;response to starvation#GO:0042594 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG103288|UniProtKB=T1EDF4 T1EDF4 20194606 PTHR10361:SF28 SODIUM-BILE ACID COTRANSPORTER P3 PROTEIN-RELATED primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG141185|UniProtKB=T1EJ28 T1EJ28 20196578 PTHR24416:SF580 TYROSINE-PROTEIN KINASE RECEPTOR DISCOIDIN DOMAIN RECEPTOR, ISOFORM F signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888;transferase activity#GO:0016740;transmembrane receptor protein kinase activity#GO:0019199;collagen binding#GO:0005518;molecular transducer activity#GO:0060089;protein-containing complex binding#GO:0044877;catalytic activity, acting on a protein#GO:0140096 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;regulation of cellular component organization#GO:0051128;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;regulation of plasma membrane bounded cell projection organization#GO:0120035;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;regulation of neuron projection development#GO:0010975;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;anatomical structure development#GO:0048856;regulation of cell projection organization#GO:0031344;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG82006|UniProtKB=T1G4L7 T1G4L7 20216015 PTHR13387:SF9 PROTEIN HGH1 HOMOLOG PROTEIN HGH1 HOMOLOG HELRO|EnsemblGenome=HelroG97580|UniProtKB=T1G9H7 T1G9H7 20217724 PTHR13720:SF50 WD-40 REPEAT PROTEIN ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 2 cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule-based process#GO:0007017;organelle organization#GO:0006996 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;mitotic spindle#GO:0072686;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;spindle#GO:0005819;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG187766|UniProtKB=T1FPD0 T1FPD0 20210677 PTHR12081:SF7 TRANSCRIPTION FACTOR E2F TRANSCRIPTION FACTOR EFL-3 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG185687|UniProtKB=T1FN54 T1FN54 20210252 PTHR43851:SF3 FAMILY NOT NAMED COENZYME Q8 HELRO|EnsemblGenome=HelroG180867|UniProtKB=T1FGC6 T1FGC6 20207875 PTHR45776:SF2 MIP04163P MIP04163P sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG119961|UniProtKB=T1EGP1 T1EGP1 20195741 PTHR11533:SF299 PROTEASE M1 ZINC METALLOPROTEASE AMINOPEPTIDASE metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;amide binding#GO:0033218;metal ion binding#GO:0046872;peptidase activity#GO:0008233;metalloaminopeptidase activity#GO:0070006;cation binding#GO:0043169;peptide binding#GO:0042277;hydrolase activity#GO:0016787;aminopeptidase activity#GO:0004177;exopeptidase activity#GO:0008238;ion binding#GO:0043167;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;peptide catabolic process#GO:0043171;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;membrane#GO:0016020;extracellular region#GO:0005576;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG169215|UniProtKB=T1F1L2 T1F1L2 20202712 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG78375|UniProtKB=T1G3B1 T1G3B1 20215559 PTHR12906:SF0 PROTEIN C20ORF24 RAB5-INTERACTING PROTEIN GEL COMPLEX SUBUNIT OPTI HELRO|EnsemblGenome=HelroG184656|UniProtKB=T1FLP5 T1FLP5 20209744 PTHR47160:SF8 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG82157|UniProtKB=T1G4N7 T1G4N7 20216035 PTHR11566:SF67 DYNAMIN DYNAMIN-LIKE 120 KDA PROTEIN, MITOCHONDRIAL GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;microtubule binding#GO:0008017;ribonucleoside triphosphate phosphatase activity#GO:0017111 mitochondrial fusion#GO:0008053;organelle localization#GO:0051640;transport#GO:0006810;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;organelle organization#GO:0006996;organelle fission#GO:0048285;mitochondrion organization#GO:0007005;peroxisome organization#GO:0007031;import into cell#GO:0098657;mitochondrial fission#GO:0000266;organelle fusion#GO:0048284 envelope#GO:0031975;membrane-enclosed lumen#GO:0031974;supramolecular complex#GO:0099080;mitochondrial membrane#GO:0031966;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;organelle membrane#GO:0031090;supramolecular polymer#GO:0099081;mitochondrion#GO:0005739;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;mitochondrial envelope#GO:0005740;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;mitochondrial intermembrane space#GO:0005758;cytoskeleton#GO:0005856;microtubule#GO:0005874 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG161897|UniProtKB=T1ES05 T1ES05 20199355 PTHR47372:SF11 DAUER UP-REGULATED-RELATED RE19971P HELRO|EnsemblGenome=HelroG185198|UniProtKB=T1FMH9 T1FMH9 20210028 PTHR13483:SF11 BOX C_D SNORNA PROTEIN 1-RELATED ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;biosynthetic process#GO:0009058;ribosomal large subunit biogenesis#GO:0042273;nucleobase-containing compound metabolic process#GO:0006139;RNA localization#GO:0006403;protein-RNA complex assembly#GO:0022618;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;ribosome biogenesis#GO:0042254;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;protein-RNA complex organization#GO:0071826;maturation of LSU-rRNA#GO:0000470 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG161934|UniProtKB=T1ES19 T1ES19 20199369 PTHR47204:SF1 OS02G0168900 PROTEIN RIBONUCLEASE H2 SUBUNIT C HELRO|EnsemblGenome=HelroG70594|UniProtKB=T1G090 T1G090 20214488 PTHR48160:SF1 LARGE RIBOSOMAL SUBUNIT PROTEIN EL43 LARGE RIBOSOMAL SUBUNIT PROTEIN EL43 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein complex#GO:1990904;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391 HELRO|EnsemblGenome=HelroG168889|UniProtKB=T1F136 T1F136 20202536 PTHR14167:SF92 SH3 DOMAIN-CONTAINING CIN85 AND CD2AP RELATED, ISOFORM J cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cell motility#GO:0048870;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;cell migration#GO:0016477 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG163885|UniProtKB=T1EUK9 T1EUK9 20200259 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172599|UniProtKB=T1F5L2 T1F5L2 20204111 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG66301|UniProtKB=T1FYJ4 T1FYJ4 20213892 PTHR10779:SF3 DYNEIN LIGHT CHAIN ROADBLOCK DYNEIN LIGHT CHAIN ROADBLOCK-TYPE 2 protein binding#GO:0005515;binding#GO:0005488 microtubule-based movement#GO:0007018;cellular process#GO:0009987;microtubule-based process#GO:0007017 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;microtubule cytoskeleton#GO:0015630;dynein complex#GO:0030286;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic dynein complex#GO:0005868;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG83835|UniProtKB=T1G5A9 T1G5A9 20216256 PTHR10762:SF1 DIPHTHAMIDE BIOSYNTHESIS PROTEIN 2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;primary metabolic process#GO:0044238 HELRO|EnsemblGenome=HelroG164763|UniProtKB=T1EVS3 T1EVS3 20200673 PTHR24330:SF19 HOMEOBOX PROTEIN BARH-LIKE MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG191048|UniProtKB=T1FSJ4 T1FSJ4 20211791 PTHR12121:SF34 CARBON CATABOLITE REPRESSOR PROTEIN 4 PROTEIN ANGEL catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787;3'-5'-RNA exonuclease activity#GO:0000175;exonuclease activity#GO:0004527;3'-5' exonuclease activity#GO:0008408;RNA nuclease activity#GO:0004540 mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG193316|UniProtKB=T1FUV6 T1FUV6 20212602 PTHR10649:SF12 ARYL HYDROCARBON RECEPTOR SPINELESS, ISOFORM C sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;molecular transducer activity#GO:0060089;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG160158|UniProtKB=T1EPW7 T1EPW7 20198617 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169037|UniProtKB=T1F1A5 T1F1A5 20202605 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163135|UniProtKB=T1ETP6 T1ETP6 20199946 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG75648|UniProtKB=T1G283 T1G283 20215181 PTHR13780:SF35 AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT LD22662P kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG170771|UniProtKB=T1F3E7 T1F3E7 20203346 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG108854|UniProtKB=T1EEN1 T1EEN1 20195033 PTHR45629:SF7 SNF2/RAD54 FAMILY MEMBER DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED damaged DNA-binding protein#PC00086;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG182098|UniProtKB=T1FHQ9 T1FHQ9 20208358 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191137|UniProtKB=T1FSM8 T1FSM8 20211825 PTHR18921:SF2 MYOSIN HEAVY CHAIN - RELATED THYROID RECEPTOR-INTERACTING PROTEIN 11 enzyme binding#GO:0019899;protein binding#GO:0005515;small GTPase binding#GO:0031267;binding#GO:0005488 localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;Golgi organization#GO:0007030;establishment of localization#GO:0051234;organelle organization#GO:0006996;transport#GO:0006810;endomembrane system organization#GO:0010256;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;cellular component organization#GO:0016043;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG172141|UniProtKB=T1F523 T1F523 20203922 PTHR17616:SF8 YES-ASSOCIATED PROTEIN YAP1 FAMILY MEMBER TRANSCRIPTIONAL COACTIVATOR YORKIE transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 positive regulation of nitrogen compound metabolic process#GO:0051173;signal transduction#GO:0007165;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;intracellular signal transduction#GO:0035556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;hippo signaling#GO:0035329;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG184986|UniProtKB=T1FM83 T1FM83 20209932 PTHR23291:SF32 BAX INHIBITOR-RELATED BAX INHIBITOR 1 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 Apoptosis signaling pathway#P00006>Bi1#P00277 HELRO|EnsemblGenome=HelroG194896|UniProtKB=T1FWJ3 T1FWJ3 20213188 PTHR13063:SF10 ENOS INTERACTING PROTEIN NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG157218|UniProtKB=T1EM85 T1EM85 20197685 PTHR15172:SF1 GALACTOCEREBROSIDASE GALACTOCEREBROSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;carbohydrate derivative catabolic process#GO:1901136;glycolipid metabolic process#GO:0006664;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;lipid catabolic process#GO:0016042;cellular process#GO:0009987;liposaccharide metabolic process#GO:1903509;sphingolipid metabolic process#GO:0006665;primary metabolic process#GO:0044238;ceramide metabolic process#GO:0006672;membrane lipid metabolic process#GO:0006643;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;sphingolipid catabolic process#GO:0030149;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248 cytoplasm#GO:0005737;lysosome#GO:0005764;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;lytic vacuole#GO:0000323;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 galactosidase#PC00104 HELRO|EnsemblGenome=HelroG100688|UniProtKB=T1ED12 T1ED12 20194464 PTHR12435:SF2 FAMILY NOT NAMED PROTEIN KTI12 HOMOLOG cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;tRNA metabolic process#GO:0006399;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;tRNA wobble uridine modification#GO:0002098;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG74876|UniProtKB=T1G1X0 T1G1X0 20215068 PTHR11827:SF103 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium ion transmembrane transporter activity#GO:0015079;sodium ion transmembrane transporter activity#GO:0015081;symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;chloride transmembrane transporter activity#GO:0015108;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 inorganic ion homeostasis#GO:0098771;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;sodium ion homeostasis#GO:0055078;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;inorganic anion transmembrane transport#GO:0098661;import across plasma membrane#GO:0098739;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;inorganic anion transport#GO:0015698;potassium ion transport#GO:0006813;regulation of anatomical structure size#GO:0090066;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;monoatomic anion transmembrane transport#GO:0098656;chloride transport#GO:0006821;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;cellular component organization#GO:0016043;cellular process#GO:0009987;chemical homeostasis#GO:0048878;regulation of cellular component size#GO:0032535;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;sodium ion transport#GO:0006814;regulation of cell size#GO:0008361;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;sodium ion transmembrane transport#GO:0035725;potassium ion import across plasma membrane#GO:1990573 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG178780|UniProtKB=T1FDQ4 T1FDQ4 20206953 PTHR12766:SF7 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DEATH DOMAIN-ASSOCIATED PROTEIN 6 FAS signaling pathway#P00020>DAXX#P00602;Apoptosis signaling pathway#P00006>DAXX#P00296 HELRO|EnsemblGenome=HelroG74787|UniProtKB=T1G1V5 T1G1V5 20215053 PTHR19871:SF14 BETA TRANSDUCIN-RELATED PROTEIN DUF4062 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG69301|UniProtKB=T1FZT1 T1FZT1 20214329 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-LIKE 1 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;localization#GO:0051179;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 membrane protein complex#GO:0098796;synapse#GO:0045202;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron projection#GO:0043005;transmembrane transporter complex#GO:1902495;cell projection#GO:0042995;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HELRO|EnsemblGenome=HelroG65129|UniProtKB=T1FY35 T1FY35 20213733 PTHR16222:SF26 ADP-RIBOSYLGLYCOHYDROLASE ADP-RIBOSYLHYDROLASE ARH1 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG144773|UniProtKB=T1EJG2 T1EJG2 20196712 PTHR23033:SF14 BETA1,3-GALACTOSYLTRANSFERASE GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED galactosyltransferase activity#GO:0008378;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG182409|UniProtKB=T1FI56 T1FI56 20208505 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG106052|UniProtKB=T1EDZ7 T1EDZ7 20194799 PTHR10687:SF61 SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN localization#GO:0051179;organic substance transport#GO:0071702;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;protein transport#GO:0015031;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 bounding membrane of organelle#GO:0098588;trans-Golgi network#GO:0005802;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;trans-Golgi network membrane#GO:0032588;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;recycling endosome membrane#GO:0055038;organelle#GO:0043226;endosome membrane#GO:0010008;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;recycling endosome#GO:0055037;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791;cytoplasmic vesicle membrane#GO:0030659 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG189993|UniProtKB=T1FRK5 T1FRK5 20211452 PTHR23033:SF14 BETA1,3-GALACTOSYLTRANSFERASE GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED galactosyltransferase activity#GO:0008378;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG145858|UniProtKB=T1EJN4 T1EJN4 20196784 PTHR45787:SF13 LD11652P LD11652P HELRO|EnsemblGenome=HelroG182633|UniProtKB=T1FII5 T1FII5 20208634 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG75645|UniProtKB=T1G282 T1G282 20215180 PTHR11575:SF24 5'-NUCLEOTIDASE-RELATED 5'-NUCLEOTIDASE phosphodiesterase#PC00185;metabolite interconversion enzyme#PC00262 Pyrimidine Metabolism#P02771>5'-Nucleotidase#P03131;Purine metabolism#P02769>5'-Nucleotidase#P03119 HELRO|EnsemblGenome=HelroG126295|UniProtKB=T1EH92 T1EH92 20195942 PTHR22978:SF22 B-CELL TRANSLOCATION GENE BTG FAMILY PROTEIN cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG158313|UniProtKB=T1EMM7 T1EMM7 20197827 PTHR21461:SF87 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GH12965P transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 glycosylation#GO:0070085;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG194133|UniProtKB=T1FVQ5 T1FVQ5 20212901 PTHR13859:SF11 ATROPHIN-RELATED GRUNGE, ISOFORM J transcription coregulator activity#GO:0003712;molecular adaptor activity#GO:0060090;transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;protein-macromolecule adaptor activity#GO:0030674 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG190625|UniProtKB=T1FS54 T1FS54 20211651 PTHR31247:SF5 TRANSMEMBRANE PROTEIN 198 FAMILY MEMBER DUF4203 DOMAIN-CONTAINING PROTEIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG67729|UniProtKB=T1FZ46 T1FZ46 20214094 PTHR18966:SF422 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED signaling receptor activity#GO:0038023;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;ligand-gated channel activity#GO:0022834 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019 HELRO|EnsemblGenome=HelroG163938|UniProtKB=T1EUM8 T1EUM8 20200278 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG80744|UniProtKB=T1G448 T1G448 20215846 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG88652|UniProtKB=T1G750 T1G750 20216897 PTHR20854:SF4 INOSITOL MONOPHOSPHATASE INOSITOL-1-MONOPHOSPHATASE-RELATED inositol phosphate phosphatase activity#GO:0052745;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 regulation of biological process#GO:0050789;organic hydroxy compound metabolic process#GO:1901615;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;alcohol metabolic process#GO:0006066;cellular process#GO:0009987;signaling#GO:0023052;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG194327|UniProtKB=T1FVX9 T1FVX9 20212975 PTHR31233:SF6 BICAUDAL D FAMILY MEMBER PROTEIN BICAUDAL D cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;dynein complex binding#GO:0070840 regulation of microtubule-based process#GO:0032886;cellular localization#GO:0051641;macromolecule localization#GO:0033036;regulation of organelle organization#GO:0033043;microtubule cytoskeleton organization#GO:0000226;regulation of cellular component organization#GO:0051128;cellular component organization#GO:0016043;cellular process#GO:0009987;protein localization#GO:0008104;localization#GO:0051179;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cytoskeleton organization#GO:0051493;cellular macromolecule localization#GO:0070727;microtubule-based process#GO:0007017;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;regulation of microtubule cytoskeleton organization#GO:0070507;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;protein localization to organelle#GO:0033365 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG177004|UniProtKB=T1FB45 T1FB45 20206044 PTHR22906:SF43 PROPERDIN PROPERDIN HELRO|EnsemblGenome=HelroG86902|UniProtKB=T1G6I9 T1G6I9 20216686 PTHR21109:SF0 MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S21 SMALL RIBOSOMAL SUBUNIT PROTEIN BS21M ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG71576|UniProtKB=T1G0N8 T1G0N8 20214636 PTHR10075:SF100 BASIGIN RELATED FASCICLIN-2 cell adhesion molecule binding#GO:0050839;cell-cell adhesion mediator activity#GO:0098632;protein binding#GO:0005515;binding#GO:0005488 neuron projection guidance#GO:0097485;cell recognition#GO:0008037;neurogenesis#GO:0022008;cell projection organization#GO:0030030;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;axonogenesis#GO:0007409;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156;cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cell morphogenesis#GO:0000902;cellular process#GO:0009987;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure development#GO:0048856;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;axon#GO:0030424 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG138932|UniProtKB=T1EIY2 T1EIY2 20196532 PTHR23310:SF77 ACYL-COA-BINDING PROTEIN, ACBP LD25952P carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;amide binding#GO:0033218;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;lipid binding#GO:0008289;anion binding#GO:0043168;ion binding#GO:0043167 lipid metabolic process#GO:0006629;oxoacid metabolic process#GO:0043436;fatty acid metabolic process#GO:0006631;cellular metabolic process#GO:0044237;cellular process#GO:0009987;cellular lipid metabolic process#GO:0044255;organic acid metabolic process#GO:0006082;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG102635|UniProtKB=T1EDA6 T1EDA6 20194558 PTHR46205:SF3 LOQUACIOUS, ISOFORM B LOQUACIOUS, ISOFORM B HELRO|EnsemblGenome=HelroG99061|UniProtKB=T1G9Q7 T1G9Q7 20217803 PTHR12498:SF0 N-TERMINAL ASPARAGINE AMIDOHYDROLASE PROTEIN N-TERMINAL ASPARAGINE AMIDOHYDROLASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191408|UniProtKB=T1FSY6 T1FSY6 20211933 PTHR23220:SF122 INTEGRIN ALPHA INTEGRIN ALPHA-PS1 cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;integrin binding#GO:0005178;binding#GO:0005488;signaling receptor binding#GO:0005102 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;cell adhesion mediated by integrin#GO:0033627;cell-cell adhesion#GO:0098609;cell communication#GO:0007154;cell adhesion#GO:0007155;cell-substrate adhesion#GO:0031589;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cell-matrix adhesion#GO:0007160;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;integrin-mediated signaling pathway#GO:0007229;biological regulation#GO:0065007;signaling#GO:0023052 receptor complex#GO:0043235;membrane protein complex#GO:0098796;external side of plasma membrane#GO:0009897;cell surface#GO:0009986;protein-containing complex#GO:0032991;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;side of membrane#GO:0098552;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;integrin#PC00126 Integrin signalling pathway#P00034>Integrin alpha#P00941 HELRO|EnsemblGenome=HelroG176884|UniProtKB=T1FB05 T1FB05 20206004 PTHR33562:SF20 ATILLA, ISOFORM B-RELATED-RELATED PROTEIN QUIVER HELRO|EnsemblGenome=HelroG83294|UniProtKB=T1G536 T1G536 20216184 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG193368|UniProtKB=T1FUX4 T1FUX4 20212620 PTHR45868:SF80 HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 33-RELATED F15K9.8-RELATED HELRO|EnsemblGenome=HelroG170481|UniProtKB=T1F340 T1F340 20203239 PTHR12080:SF48 SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE IMMUNOGLOBULIN SUBTYPE DOMAIN-CONTAINING PROTEIN immunoglobulin receptor superfamily#PC00124 HELRO|EnsemblGenome=HelroG182229|UniProtKB=T1FHY7 T1FHY7 20208436 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG78298|UniProtKB=T1G3A5 T1G3A5 20215553 PTHR11817:SF3 PYRUVATE KINASE AT14039P-RELATED transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;ribonucleoside triphosphate metabolic process#GO:0009199;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative metabolic process#GO:1901135;heterocycle catabolic process#GO:0046700;organonitrogen compound catabolic process#GO:1901565;ribonucleotide catabolic process#GO:0009261;pyridine nucleotide metabolic process#GO:0019362;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;cellular nitrogen compound catabolic process#GO:0044270;purine-containing compound catabolic process#GO:0072523;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;purine nucleotide catabolic process#GO:0006195;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;purine ribonucleotide catabolic process#GO:0009154;nucleoside phosphate metabolic process#GO:0006753;carbohydrate catabolic process#GO:0016052;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;catabolic process#GO:0009056;nucleoside diphosphate metabolic process#GO:0009132;organic substance catabolic process#GO:1901575;carbohydrate metabolic process#GO:0005975;purine nucleotide metabolic process#GO:0006163;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;oxoacid metabolic process#GO:0043436;nucleoside phosphate catabolic process#GO:1901292;carbohydrate derivative catabolic process#GO:1901136;purine ribonucleoside triphosphate metabolic process#GO:0009205;generation of precursor metabolites and energy#GO:0006091;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;nucleotide catabolic process#GO:0009166;cellular nitrogen compound metabolic process#GO:0034641;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;nucleoside diphosphate catabolic process#GO:0009134;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;organophosphate catabolic process#GO:0046434;aromatic compound catabolic process#GO:0019439;glycolytic process#GO:0006096;organic cyclic compound catabolic process#GO:1901361;organophosphate metabolic process#GO:0019637;purine nucleoside triphosphate metabolic process#GO:0009144;nucleobase-containing compound catabolic process#GO:0034655;nucleotide metabolic process#GO:0009117;carboxylic acid metabolic process#GO:0019752;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 kinase#PC00137 Pyruvate metabolism#P02772>Pyruvate Kinase#P03132 HELRO|EnsemblGenome=HelroG189827|UniProtKB=T1FRE5 T1FRE5 20211392 PTHR14134:SF2 E3 UBIQUITIN-PROTEIN LIGASE RAD18 E3 UBIQUITIN-PROTEIN LIGASE RAD18 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;postreplication repair#GO:0006301;protein monoubiquitination#GO:0006513;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;post-translational protein modification#GO:0043687;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;response to stress#GO:0006950;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;metabolic process#GO:0008152 protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185021|UniProtKB=T1FMA6 T1FMA6 20209955 PTHR45962:SF1 N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1 N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG172769|UniProtKB=T1F5X1 T1F5X1 20204220 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG189271|UniProtKB=T1FQW5 T1FQW5 20211212 PTHR33604:SF3 OSJNBA0004B13.7 PROTEIN OSJNBA0004B13.7 PROTEIN HELRO|EnsemblGenome=HelroG111676|UniProtKB=T1EFD6 T1EFD6 20195288 PTHR12566:SF12 CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB TRANSLATIONAL REGULATOR ORB2 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;translation regulator activity#GO:0045182;binding#GO:0005488;organic cyclic compound binding#GO:0097159;ribonucleoprotein complex binding#GO:0043021;ribosome binding#GO:0043022;mRNA binding#GO:0003729;protein-containing complex binding#GO:0044877;translation regulator activity, nucleic acid binding#GO:0090079;translation factor activity, RNA binding#GO:0008135;mRNA 3'-UTR binding#GO:0003730 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of protein metabolic process#GO:0051246;negative regulation of biosynthetic process#GO:0009890;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of translation#GO:0017148;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;synapse#GO:0045202;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;neuron projection#GO:0043005;cell junction#GO:0030054;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG77715|UniProtKB=T1G330 T1G330 20215478 PTHR24055:SF52 MITOGEN-ACTIVATED PROTEIN KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG168226|UniProtKB=T1F0C0 T1F0C0 20202270 PTHR24115:SF9 KINESIN-RELATED KINESIN HEAVY CHAIN cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;plus-end-directed microtubule motor activity#GO:0008574;binding#GO:0005488;catalytic activity#GO:0003824;cytoskeletal motor activity#GO:0003774;microtubule binding#GO:0008017;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887;pyrophosphatase activity#GO:0016462;microtubule motor activity#GO:0003777;ATP-dependent activity#GO:0140657;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817 localization#GO:0051179;cellular localization#GO:0051641;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;transport#GO:0006810;cytoskeleton-dependent intracellular transport#GO:0030705;microtubule-based movement#GO:0007018;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;microtubule associated complex#GO:0005875;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG95426|UniProtKB=T1G958 T1G958 20217605 PTHR13016:SF0 AMMECR1 HOMOLOG AMME SYNDROME CANDIDATE GENE 1 PROTEIN HELRO|EnsemblGenome=HelroG171671|UniProtKB=T1F4J2 T1F4J2 20203741 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77216|UniProtKB=T1G2U5 T1G2U5 20215393 PTHR12247:SF104 POLYCOMB GROUP PROTEIN POLYCOMB PROTEIN SFMBT protein binding#GO:0005515;protein-containing complex binding#GO:0044877;histone binding#GO:0042393;binding#GO:0005488;chromatin binding#GO:0003682 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG191072|UniProtKB=T1FSK2 T1FSK2 20211799 PTHR20992:SF9 AT15442P-RELATED AT15442P-RELATED HELRO|EnsemblGenome=HelroG157299|UniProtKB=T1EM90 T1EM90 20197690 PTHR12398:SF20 PROTEIN PHOSPHATASE INHIBITOR PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2 phosphatase regulator activity#GO:0019208;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888;enzyme inhibitor activity#GO:0004857;phosphatase inhibitor activity#GO:0019212;molecular function inhibitor activity#GO:0140678;protein phosphatase inhibitor activity#GO:0004864;enzyme regulator activity#GO:0030234 regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;regulation of nitrogen compound metabolic process#GO:0051171;regulation of phosphatase activity#GO:0010921;regulation of dephosphorylation#GO:0035303;regulation of catalytic activity#GO:0050790;regulation of phosphorus metabolic process#GO:0051174;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of molecular function#GO:0065009;biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336;regulation of phosphoprotein phosphatase activity#GO:0043666;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 phosphatase modulator#PC00184;phosphatase inhibitor#PC00183 HELRO|EnsemblGenome=HelroG165069|UniProtKB=T1EW89 T1EW89 20200839 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG63543|UniProtKB=T1FXH1 T1FXH1 20213519 PTHR13088:SF3 FAS APOPTOTIC INHIBITORY MOLECULE FAIM FAS APOPTOTIC INHIBITORY MOLECULE 1 regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of apoptotic process#GO:0042981;negative regulation of apoptotic signaling pathway#GO:2001234;negative regulation of response to stimulus#GO:0048585;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of extrinsic apoptotic signaling pathway#GO:2001236;regulation of apoptotic signaling pathway#GO:2001233;negative regulation of apoptotic process#GO:0043066;regulation of response to stimulus#GO:0048583;negative regulation of extrinsic apoptotic signaling pathway#GO:2001237;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;negative regulation of programmed cell death#GO:0043069;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of cellular process#GO:0048523;negative regulation of cell communication#GO:0010648;regulation of programmed cell death#GO:0043067 HELRO|EnsemblGenome=HelroG185280|UniProtKB=T1FML7 T1FML7 20210066 PTHR12732:SF0 UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING PCI DOMAIN-CONTAINING PROTEIN 2 RNA binding#GO:0003723;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;cellular localization#GO:0051641;macromolecule localization#GO:0033036;RNA metabolic process#GO:0016070;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA localization#GO:0006403;organic substance transport#GO:0071702;organic cyclic compound metabolic process#GO:1901360;transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000972;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;RNA transport#GO:0050658;cellular nitrogen compound biosynthetic process#GO:0044271;transcription elongation by RNA polymerase II#GO:0006368;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;poly(A)+ mRNA export from nucleus#GO:0016973;mRNA export from nucleus#GO:0006406;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;DNA-templated transcription elongation#GO:0006354;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;mRNA transport#GO:0051028;primary metabolic process#GO:0044238;post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000973;heterocycle biosynthetic process#GO:0018130;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;nuclear export#GO:0051168;organelle organization#GO:0006996;chromosome organization#GO:0051276;nucleocytoplasmic transport#GO:0006913;nucleobase-containing compound transport#GO:0015931;aromatic compound biosynthetic process#GO:0019438;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;transcription by RNA polymerase II#GO:0006366 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;transcription export complex 2#GO:0070390;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG122800|UniProtKB=T1EGW0 T1EGW0 20195810 PTHR11132:SF515 SOLUTE CARRIER FAMILY 35 SOLUTE CARRIER FAMILY 35 MEMBER D3 secondary active transmembrane transporter activity#GO:0015291;antiporter activity#GO:0015297;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG167439|UniProtKB=T1EZD7 T1EZD7 20201937 PTHR10024:SF234 SYNAPTOTAGMIN SYNAPTOTAGMIN-15-RELATED cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;phosphatidylserine binding#GO:0001786;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;protein binding#GO:0005515;clathrin binding#GO:0030276;lipid binding#GO:0008289;ion binding#GO:0043167;phospholipid binding#GO:0005543;SNARE binding#GO:0000149 localization#GO:0051179;regulated exocytosis#GO:0045055;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;calcium-ion regulated exocytosis#GO:0017156;export from cell#GO:0140352;secretion by cell#GO:0032940 intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;secretory vesicle#GO:0099503;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG76592|UniProtKB=T1G2M0 T1G2M0 20215318 PTHR12276:SF115 EPSIN/ENT-RELATED FI19443P1 protein binding#GO:0005515;lipid binding#GO:0008289;clathrin binding#GO:0030276;phospholipid binding#GO:0005543;binding#GO:0005488 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;import into cell#GO:0098657;transport#GO:0006810;endocytosis#GO:0006897 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;clathrin vesicle coat#GO:0030125;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;vesicle coat#GO:0030120;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;clathrin-coated vesicle#GO:0030136;endomembrane system#GO:0012505;membrane coat#GO:0030117;coated vesicle membrane#GO:0030662;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;coated membrane#GO:0048475;cytoplasmic vesicle membrane#GO:0030659;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG165241|UniProtKB=T1EWH5 T1EWH5 20200925 PTHR12766:SF7 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DEATH DOMAIN-ASSOCIATED PROTEIN 6 FAS signaling pathway#P00020>DAXX#P00602;Apoptosis signaling pathway#P00006>DAXX#P00296 HELRO|EnsemblGenome=HelroG168706|UniProtKB=T1F0V6 T1F0V6 20202456 PTHR46007:SF8 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 C2H2-TYPE DOMAIN-CONTAINING PROTEIN molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;protein binding#GO:0005515;transcription factor binding#GO:0008134 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG186116|UniProtKB=T1FNP1 T1FNP1 20210438 PTHR33444:SF2 SI:DKEY-19B23.12-RELATED MARVEL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162852|UniProtKB=T1ETA0 T1ETA0 20199800 PTHR45749:SF21 FAMILY NOT NAMED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG95052|UniProtKB=T1G943 T1G943 20217590 PTHR11255:SF118 DIACYLGLYCEROL KINASE DIACYLGLYCEROL KINASE EPSILON transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301;lipid kinase activity#GO:0001727 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transferase#PC00220;kinase#PC00137;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG64710|UniProtKB=T1FXY2 T1FXY2 20213680 PTHR20940:SF1 TETRA THYMOSIN CIBOULOT, ISOFORM A cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;actin binding#GO:0003779;binding#GO:0005488;actin monomer binding#GO:0003785 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG194479|UniProtKB=T1FW37 T1FW37 20213033 PTHR16017:SF0 GASTRULATION DEFECTIVE PROTEIN 1-RELATED WD REPEAT-CONTAINING PROTEIN 70 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;site of DNA damage#GO:0090734;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;site of double-strand break#GO:0035861;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG191892|UniProtKB=T1FTE3 T1FTE3 20212090 PTHR31802:SF3 32 KDA HEAT SHOCK PROTEIN-RELATED 32 KDA HEAT SHOCK PROTEIN intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG158516|UniProtKB=T1EMW3 T1EMW3 20197913 PTHR47020:SF1 HILLARIN HILLARIN HELRO|EnsemblGenome=HelroG170120|UniProtKB=T1F2N9 T1F2N9 20203088 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183636|UniProtKB=T1FJZ0 T1FJZ0 20209139 PTHR16021:SF18 MANSC DOMAIN CONTAINING PROTEIN 1 GROUP-SPECIFIC ANTIGEN HELRO|EnsemblGenome=HelroG162705|UniProtKB=T1ET12 T1ET12 20199712 PTHR12442:SF11 DYNEIN INTERMEDIATE CHAIN DYNEIN AXONEMAL INTERMEDIATE CHAIN 1 protein binding#GO:0005515;binding#GO:0005488 cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;outer dynein arm assembly#GO:0036158;cell projection organization#GO:0030030;microtubule cytoskeleton organization#GO:0000226;microtubule-based movement#GO:0007018;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;axoneme assembly#GO:0035082;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;cilium movement#GO:0003341;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection assembly#GO:0120031 axoneme#GO:0005930;outer dynein arm#GO:0036157;catalytic complex#GO:1902494;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;microtubule associated complex#GO:0005875;axonemal dynein complex#GO:0005858;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;ciliary plasm#GO:0097014;plasma membrane bounded cell projection cytoplasm#GO:0032838;membrane-bounded organelle#GO:0043227;dynein complex#GO:0030286;cell projection#GO:0042995;cytoskeleton#GO:0005856;cilium#GO:0005929 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG168488|UniProtKB=T1F0M6 T1F0M6 20202376 PTHR33844:SF1 SULFOTRANSFER_1 DOMAIN-CONTAINING PROTEIN SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166963|UniProtKB=T1EYT5 T1EYT5 20201735 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167925|UniProtKB=T1EZY9 T1EZY9 20202139 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG100028|UniProtKB=T1ECY2 T1ECY2 20194434 PTHR48041:SF116 ABC TRANSPORTER G FAMILY MEMBER 28 PROTEIN BROWN transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG92768|UniProtKB=T1G8K7 T1G8K7 20217404 PTHR46289:SF17 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193935|UniProtKB=T1FVH5 T1FVH5 20212821 PTHR12920:SF4 RYBP AND YAF2-RELATED GEO03726P1 molecular adaptor activity#GO:0060090;nucleic acid binding#GO:0003676;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;binding#GO:0005488;organic cyclic compound binding#GO:0097159;protein-macromolecule adaptor activity#GO:0030674;DNA binding#GO:0003677 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG163117|UniProtKB=T1ETP1 T1ETP1 20199941 PTHR22738:SF10 RASSF RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 1 HOMOLOG regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG98035|UniProtKB=T1G9K2 T1G9K2 20217748 PTHR10890:SF3 CYSTEINYL-TRNA SYNTHETASE CYSTEINE--TRNA LIGASE, CYTOPLASMIC catalytic activity, acting on RNA#GO:0140098;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;ligase activity#GO:0016874;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;catalytic activity, acting on a nucleic acid#GO:0140640;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168;ATP binding#GO:0005524 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG192112|UniProtKB=T1FTL2 T1FTL2 20212159 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cell communication#GO:0007154;cellular process#GO:0009987;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;Notch signaling pathway#GO:0007219 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG182195|UniProtKB=T1FHW7 T1FHW7 20208416 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192215|UniProtKB=T1FTP9 T1FTP9 20212196 PTHR16861:SF4 GLYCOPROTEIN 38 SH3 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G13610) HELRO|EnsemblGenome=HelroG178502|UniProtKB=T1FD99 T1FD99 20206798 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG79617|UniProtKB=T1G3R1 T1G3R1 20215709 PTHR31609:SF1 YDJC DEACETYLASE FAMILY MEMBER CARBOHYDRATE DEACETYLASE hydrolase activity#GO:0016787;deacetylase activity#GO:0019213;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG111285|UniProtKB=T1EFA1 T1EFA1 20195253 PTHR14859:SF1 CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR PGAP2-INTERACTING PROTEIN lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;phospholipid biosynthetic process#GO:0008654;macromolecule modification#GO:0043412;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycolipid metabolic process#GO:0006664;protein modification process#GO:0036211;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;glycerolipid biosynthetic process#GO:0045017;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;organic substance biosynthetic process#GO:1901576;liposaccharide metabolic process#GO:1903509;cellular process#GO:0009987;GPI anchor metabolic process#GO:0006505;membrane lipid biosynthetic process#GO:0046467;lipoprotein biosynthetic process#GO:0042158;primary metabolic process#GO:0044238;GPI anchor biosynthetic process#GO:0006506;carbohydrate derivative biosynthetic process#GO:1901137;membrane lipid metabolic process#GO:0006643;glycerophospholipid biosynthetic process#GO:0046474;glycolipid biosynthetic process#GO:0009247;organophosphate metabolic process#GO:0019637;lipoprotein metabolic process#GO:0042157;cellular lipid metabolic process#GO:0044255 HELRO|EnsemblGenome=HelroG188529|UniProtKB=T1FQ34 T1FQ34 20210931 PTHR23065:SF15 PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1 AT02057P cytoplasm#GO:0005737;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG185065|UniProtKB=T1FMC7 T1FMC7 20209976 PTHR21139:SF2 TRIOSEPHOSPHATE ISOMERASE TRIOSEPHOSPHATE ISOMERASE isomerase activity#GO:0016853;catalytic activity#GO:0003824 ribonucleoside triphosphate metabolic process#GO:0009199;nucleoside triphosphate metabolic process#GO:0009141;heterocycle catabolic process#GO:0046700;ribonucleotide catabolic process#GO:0009261;pyridine nucleotide metabolic process#GO:0019362;nucleobase-containing compound metabolic process#GO:0006139;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;purine ribonucleotide catabolic process#GO:0009154;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;organic hydroxy compound metabolic process#GO:1901615;oxoacid metabolic process#GO:0043436;nucleoside phosphate catabolic process#GO:1901292;carbohydrate derivative catabolic process#GO:1901136;purine ribonucleoside triphosphate metabolic process#GO:0009205;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;nucleotide catabolic process#GO:0009166;alcohol metabolic process#GO:0006066;cellular nitrogen compound metabolic process#GO:0034641;nicotinamide nucleotide metabolic process#GO:0046496;nucleoside diphosphate catabolic process#GO:0009134;organic acid metabolic process#GO:0006082;ribonucleotide metabolic process#GO:0009259;monocarboxylic acid metabolic process#GO:0032787;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;organophosphate catabolic process#GO:0046434;carbohydrate derivative biosynthetic process#GO:1901137;hexose biosynthetic process#GO:0019319;small molecule catabolic process#GO:0044282;glycolytic process#GO:0006096;organophosphate metabolic process#GO:0019637;small molecule biosynthetic process#GO:0044283;nucleobase-containing compound catabolic process#GO:0034655;nucleotide metabolic process#GO:0009117;small molecule metabolic process#GO:0044281;cellular aromatic compound metabolic process#GO:0006725;monosaccharide metabolic process#GO:0005996;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;organonitrogen compound catabolic process#GO:1901565;biosynthetic process#GO:0009058;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;purine-containing compound catabolic process#GO:0072523;cellular nitrogen compound catabolic process#GO:0044270;purine nucleotide catabolic process#GO:0006195;organic cyclic compound metabolic process#GO:1901360;carbohydrate catabolic process#GO:0016052;catabolic process#GO:0009056;nucleoside diphosphate metabolic process#GO:0009132;organic substance catabolic process#GO:1901575;carbohydrate metabolic process#GO:0005975;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;carbohydrate biosynthetic process#GO:0016051;heterocycle metabolic process#GO:0046483;organonitrogen compound metabolic process#GO:1901564;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;glucose metabolic process#GO:0006006;aromatic compound catabolic process#GO:0019439;organic cyclic compound catabolic process#GO:1901361;purine nucleoside triphosphate metabolic process#GO:0009144;hexose metabolic process#GO:0019318;carboxylic acid metabolic process#GO:0019752;nucleobase-containing small molecule metabolic process#GO:0055086 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 isomerase#PC00135;metabolite interconversion enzyme#PC00262 Glycolysis#P00024>Triosephosphate isomerase#P00673 HELRO|EnsemblGenome=HelroG159979|UniProtKB=T1EPM2 T1EPM2 20198522 PTHR12801:SF115 RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED FI18136P1-RELATED hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;exonuclease activity#GO:0004527;catalytic activity#GO:0003824 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;exoribonuclease#PC00099 DNA replication#P00017>RNase H#P00538 HELRO|EnsemblGenome=HelroG194984|UniProtKB=T1FWM5 T1FWM5 20213220 PTHR11388:SF142 ORGANIC ANION TRANSPORTER SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 5A1 secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;organic substance transport#GO:0071702;establishment of localization#GO:0051234;organic anion transport#GO:0015711;transport#GO:0006810 basal plasma membrane#GO:0009925;basolateral plasma membrane#GO:0016323;plasma membrane region#GO:0098590;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;basal part of cell#GO:0045178;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG173013|UniProtKB=T1F696 T1F696 20204345 PTHR19303:SF74 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG77631|UniProtKB=T1G312 T1G312 20215460 PTHR20208:SF10 STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1 STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1 hydrolase activity, acting on ester bonds#GO:0016788;DNA endonuclease activity#GO:0004520;nuclease activity#GO:0004518;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;double-strand break repair via homologous recombination#GO:0000724;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;response to stress#GO:0006950;nitrogen compound metabolic process#GO:0006807;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 endodeoxyribonuclease#PC00093 Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388 HELRO|EnsemblGenome=HelroG157495|UniProtKB=T1EMC3 T1EMC3 20197723 PTHR22850:SF214 WD40 REPEAT FAMILY CHROMATIN ASSEMBLY FACTOR 1 P55 SUBUNIT nucleosome binding#GO:0031491;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;histone binding#GO:0042393;binding#GO:0005488;chromatin binding#GO:0003682 protein-DNA complex organization#GO:0071824;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;cellular component organization#GO:0016043;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG164909|UniProtKB=T1EVY6 T1EVY6 20200736 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172433|UniProtKB=T1F5B7 T1F5B7 20204016 PTHR11850:SF295 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS ACHINTYA, ISOFORM C-RELATED DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG171557|UniProtKB=T1F4E6 T1F4E6 20203695 PTHR23055:SF172 CALCIUM BINDING PROTEINS EF-HAND DOMAIN-CONTAINING PROTEIN cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG107039|UniProtKB=T1EE69 T1EE69 20194871 PTHR11705:SF91 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B FI01817P-RELATED metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metallocarboxypeptidase activity#GO:0004181;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;carboxypeptidase activity#GO:0004180 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG110282|UniProtKB=T1EF10 T1EF10 20195162 PTHR46091:SF3 BLR7054 PROTEIN AMINE OXIDASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG95625|UniProtKB=T1G970 T1G970 20217617 PTHR11829:SF411 FORKHEAD BOX PROTEIN FORKHEAD BOX PROTEIN L2 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;anatomical structure morphogenesis#GO:0009653;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG126756|UniProtKB=T1EHA9 T1EHA9 20195959 PTHR23349:SF63 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST FER3-LIKE PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG164480|UniProtKB=T1EVH4 T1EVH4 20200574 PTHR24014:SF4 2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 2 2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 2 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG167326|UniProtKB=T1EZ95 T1EZ95 20201895 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG82857|UniProtKB=T1G4X5 T1G4X5 20216123 PTHR13914:SF0 PROLINE OXIDASE PROLINE DEHYDROGENASE 1, MITOCHONDRIAL oxidase#PC00175;oxidoreductase#PC00176 Huntington disease#P00029>Proline oxidase#G01529 HELRO|EnsemblGenome=HelroG83793|UniProtKB=T1G5A5 T1G5A5 20216252 PTHR11920:SF499 GUANYLYL CYCLASE GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG91367|UniProtKB=T1G830 T1G830 20217227 PTHR11216:SF31 EH DOMAIN AT21416P localization#GO:0051179;endosomal transport#GO:0016197;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;endocytosis#GO:0006897;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;cellular process#GO:0009987;import into cell#GO:0098657 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG176723|UniProtKB=T1FAU1 T1FAU1 20205940 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG67881|UniProtKB=T1FZ69 T1FZ69 20214117 PTHR22878:SF63 DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED DYNEIN AXONEMAL HEAVY CHAIN 10 Huntington disease#P00029>Dynein complex#P00774 HELRO|EnsemblGenome=HelroG155898|UniProtKB=T1ELN9 T1ELN9 20197489 PTHR45746:SF6 LP21163P LP21163P nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of cell communication#GO:0010646;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;regulation of signaling#GO:0023051;positive regulation of molecular function#GO:0044093;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;regulation of molecular function#GO:0065009;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731 HELRO|EnsemblGenome=HelroG158934|UniProtKB=T1ENF3 T1ENF3 20198103 PTHR12766:SF7 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DEATH DOMAIN-ASSOCIATED PROTEIN 6 FAS signaling pathway#P00020>DAXX#P00602;Apoptosis signaling pathway#P00006>DAXX#P00296 HELRO|EnsemblGenome=HelroG102482|UniProtKB=T1ED98 T1ED98 20194550 PTHR44340:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 10 DNAJ HOMOLOG SUBFAMILY C MEMBER 10 protein-disulfide reductase activity#GO:0015035;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;binding#GO:0005488;catalytic activity#GO:0003824;protein binding#GO:0005515;disulfide oxidoreductase activity#GO:0015036;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491 response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;endoplasmic reticulum unfolded protein response#GO:0030968;response to endoplasmic reticulum stress#GO:0034976;cellular response to chemical stimulus#GO:0070887;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to topologically incorrect protein#GO:0035967;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;response to topologically incorrect protein#GO:0035966;response to unfolded protein#GO:0006986;cellular response to unfolded protein#GO:0034620;biological regulation#GO:0065007;cellular response to stress#GO:0033554;signaling#GO:0023052 membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;endoplasmic reticulum lumen#GO:0005788;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG153381|UniProtKB=T1EL61 T1EL61 20197311 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162009|UniProtKB=T1ES53 T1ES53 20199403 PTHR48125:SF16 LP07818P1 UBZ4-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162256|UniProtKB=T1ESF4 T1ESF4 20199504 PTHR19964:SF92 MULTIPLE PDZ DOMAIN PROTEIN PATJ HOMOLOG scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG76196|UniProtKB=T1G2G6 T1G2G6 20215264 PTHR24347:SF433 SERINE/THREONINE-PROTEIN KINASE CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE I-RELATED non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191744|UniProtKB=T1FT92 T1FT92 20212039 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG112087|UniProtKB=T1EFG9 T1EFG9 20195321 PTHR23389:SF6 CHROMOSOME TRANSMISSION FIDELITY FACTOR 18 REPLICATION FACTOR C SUBUNIT 1 DNA metabolism protein#PC00009 DNA replication#P00017>RFC#P00529 HELRO|EnsemblGenome=HelroG96328|UniProtKB=T1G9B4 T1G9B4 20217661 PTHR24092:SF5 PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE PHOSPHOLIPID-TRANSPORTING ATPASE ATPase-coupled intramembrane lipid transporter activity#GO:0140326;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;lipid transporter activity#GO:0005319 organophosphate ester transport#GO:0015748;macromolecule localization#GO:0033036;membrane organization#GO:0061024;transport#GO:0006810;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;regulation of membrane lipid distribution#GO:0097035;phospholipid transport#GO:0015914;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;lipid transport#GO:0006869;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;biological regulation#GO:0065007;lipid translocation#GO:0034204;lipid localization#GO:0010876;import into cell#GO:0098657;phospholipid translocation#GO:0045332 trans-Golgi network#GO:0005802;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;organelle subcompartment#GO:0031984;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG108304|UniProtKB=T1EEI2 T1EEI2 20194984 PTHR10953:SF9 UBIQUITIN-ACTIVATING ENZYME E1 UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 5 ligase activity#GO:0016874;transferase activity#GO:0016740;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877;nucleotidyltransferase activity#GO:0016779;thiosulfate sulfurtransferase activity#GO:0004792;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity, acting on a protein#GO:0140096;sulfurtransferase activity#GO:0016783 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG77533|UniProtKB=T1G2Z5 T1G2Z5 20215443 PTHR13348:SF0 RIBONUCLEASE P SUBUNIT P29 RIBONUCLEASE P PROTEIN SUBUNIT P29 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;endoribonuclease complex#GO:1902555;ribonuclease MRP complex#GO:0000172;ribonuclease P complex#GO:0030677;catalytic complex#GO:1902494;endonuclease complex#GO:1905348;intracellular protein-containing complex#GO:0140535;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG107037|UniProtKB=T1EE67 T1EE67 20194869 PTHR11705:SF91 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B FI01817P-RELATED metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metallocarboxypeptidase activity#GO:0004181;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;carboxypeptidase activity#GO:0004180 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG80768|UniProtKB=T1G451 T1G451 20215849 PTHR46532:SF4 MALE FERTILITY FACTOR KL5 AAA+ ATPASE DOMAIN-CONTAINING PROTEIN axoneme#GO:0005930;catalytic complex#GO:1902494;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;axonemal dynein complex#GO:0005858;microtubule associated complex#GO:0005875;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;plasma membrane bounded cell projection cytoplasm#GO:0032838;ciliary plasm#GO:0097014;dynein complex#GO:0030286;cell projection#GO:0042995;cytoskeleton#GO:0005856;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG70349|UniProtKB=T1G053 T1G053 20214451 PTHR16705:SF4 COMPLEXIN COMPLEXIN protein binding#GO:0005515;binding#GO:0005488;SNARE binding#GO:0000149 SNARE complex#GO:0031201;cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG80148|UniProtKB=T1G3Y2 T1G3Y2 20215780 PTHR11362:SF133 PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN LARGE RIBOSOMAL SUBUNIT PROTEIN ML38 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrial large ribosomal subunit#GO:0005762;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;organellar ribosome#GO:0000313;protein-containing complex#GO:0032991;large ribosomal subunit#GO:0015934;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840;mitochondrial protein-containing complex#GO:0098798 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG165585|UniProtKB=T1EX13 T1EX13 20201113 PTHR46190:SF1 SI:CH211-201H21.5-RELATED SI:CH211-201H21.5 HELRO|EnsemblGenome=HelroG188473|UniProtKB=T1FQ11 T1FQ11 20210908 PTHR44267:SF1 WD REPEAT-CONTAINING PROTEIN 43 WD REPEAT-CONTAINING PROTEIN 43 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG164161|UniProtKB=T1EV08 T1EV08 20200408 PTHR46954:SF1 C2H2-TYPE DOMAIN-CONTAINING PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161330|UniProtKB=T1ERC6 T1ERC6 20199126 PTHR11985:SF15 GLYCEROL-3-PHOSPHATE DEHYDROGENASE GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG180692|UniProtKB=T1FG64 T1FG64 20207813 PTHR21439:SF0 OXIDORED-NITRO DOMAIN-CONTAINING PROTEIN PROTEIN OSCP1 localization#GO:0051179;establishment of localization#GO:0051234;transport#GO:0006810 cytoplasm#GO:0005737;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG175308|UniProtKB=T1F947 T1F947 20205346 PTHR21437:SF1 WIDE AWAKE WIDE AWAKE HELRO|EnsemblGenome=HelroG176612|UniProtKB=T1FAQ5 T1FAQ5 20205904 PTHR13297:SF9 TBC1 DOMAIN FAMILY MEMBER 23-RELATED ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG193472|UniProtKB=T1FV13 T1FV13 20212659 PTHR13455:SF7 TRANSCRIPTIONAL REPRESSOR P66-RELATED SIMJANG, ISOFORM E negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;chromosome#GO:0005694;histone deacetylase complex#GO:0000118;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG171574|UniProtKB=T1F4E9 T1F4E9 20203698 PTHR45982:SF1 REGULATOR OF CHROMOSOME CONDENSATION REGULATOR OF CHROMOSOME CONDENSATION HELRO|EnsemblGenome=HelroG62245|UniProtKB=T1FWX8 T1FWX8 20213326 PTHR12308:SF83 ANOCTAMIN ANOCTAMIN inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216 localization#GO:0051179;inorganic anion transmembrane transport#GO:0098661;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;transport#GO:0006810;chloride transport#GO:0006821;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG76708|UniProtKB=T1G2M9 T1G2M9 20215327 PTHR11662:SF279 SOLUTE CARRIER FAMILY 17 VOLTAGE-GATED PURINE NUCLEOTIDE UNIPORTER SLC17A9 localization#GO:0051179;organic substance transport#GO:0071702;organophosphate ester transport#GO:0015748;establishment of localization#GO:0051234;organic anion transport#GO:0015711;nucleobase-containing compound transport#GO:0015931;transport#GO:0006810;nitrogen compound transport#GO:0071705;carbohydrate derivative transport#GO:1901264 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG150388|UniProtKB=T1EKF5 T1EKF5 20197055 PTHR11132:SF521 SOLUTE CARRIER FAMILY 35 SOLUTE CARRIER FAMILY 35 MEMBER E2A-RELATED secondary active transmembrane transporter activity#GO:0015291;antiporter activity#GO:0015297;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG179326|UniProtKB=T1FEJ9 T1FEJ9 20207248 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG156647|UniProtKB=T1ELZ2 T1ELZ2 20197592 PTHR11476:SF7 HISTIDYL-TRNA SYNTHETASE HISTIDINE--TRNA LIGASE aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG75380|UniProtKB=T1G244 T1G244 20215142 PTHR12241:SF39 TUBULIN POLYGLUTAMYLASE TUBULIN POLYGLUTAMYLASE TTLL9-RELATED cytoskeletal protein binding#GO:0008092;ligase activity#GO:0016874;protein binding#GO:0005515;tubulin binding#GO:0015631;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;microtubule cytoskeleton organization#GO:0000226;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;cellular component organization#GO:0016043;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;nitrogen compound metabolic process#GO:0006807;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;cilium#GO:0005929;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG123898|UniProtKB=T1EGZ6 T1EGZ6 20195846 PTHR48043:SF145 EG:EG0003.4 PROTEIN-RELATED FI06409P-RELATED HELRO|EnsemblGenome=HelroG144776|UniProtKB=T1EJG3 T1EJG3 20196713 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG173711|UniProtKB=T1F753 T1F753 20204652 PTHR34153:SF2 SI:CH211-262H13.3-RELATED-RELATED SI:CH211-262H13.3-RELATED HELRO|EnsemblGenome=HelroG194546|UniProtKB=T1FW65 T1FW65 20213061 PTHR34203:SF15 METHYLTRANSFERASE, FKBM FAMILY PROTEIN SLL1173 PROTEIN methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG184264|UniProtKB=T1FKV5 T1FKV5 20209454 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG192405|UniProtKB=T1FTX1 T1FTX1 20212268 PTHR45798:SF97 RING-H2 FINGER PROTEIN ATL61-RELATED-RELATED ALCOHOL-SENSITIVE RING FINGER PROTEIN 1 HELRO|EnsemblGenome=HelroG62422|UniProtKB=T1FX04 T1FX04 20213352 PTHR24637:SF388 COLLAGEN NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184185|UniProtKB=T1FKQ6 T1FKQ6 20209405 PTHR33332:SF48 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG141083|UniProtKB=T1EJ25 T1EJ25 20196575 PTHR24356:SF418 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE WARTS transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG178878|UniProtKB=T1FDU6 T1FDU6 20206995 PTHR37002:SF10 AGAP007005-PA TRANSGLUTAMINASE-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162041|UniProtKB=T1ES66 T1ES66 20199416 PTHR12756:SF11 CYTOSOLIC CARBOXYPEPTIDASE CYTOSOLIC CARBOXYPEPTIDASE 1 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG177871|UniProtKB=T1FCE4 T1FCE4 20206493 PTHR12242:SF45 OS02G0130600 PROTEIN-RELATED MARVEL DOMAIN-CONTAINING PROTEIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG111783|UniProtKB=T1EFE5 T1EFE5 20195297 PTHR23281:SF18 MERLIN/MOESIN/EZRIN/RADIXIN MOESIN_EZRIN_RADIXIN HOMOLOG 1 cell adhesion molecule binding#GO:0050839;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;actin binding#GO:0003779;binding#GO:0005488 regulation of anatomical structure morphogenesis#GO:0022603;regulation of organelle organization#GO:0033043;positive regulation of transport#GO:0051050;regulation of localization#GO:0032879;regulation of cellular component organization#GO:0051128;regulation of cellular localization#GO:0060341;regulation of vesicle-mediated transport#GO:0060627;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of cell shape#GO:0008360;regulation of transport#GO:0051049;regulation of biological quality#GO:0065008;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;regulation of organelle assembly#GO:1902115;biological regulation#GO:0065007;positive regulation of protein localization#GO:1903829;positive regulation of biological process#GO:0048518;regulation of protein localization#GO:0032880 actin-based cell projection#GO:0098858;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;filopodium#GO:0030175 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG73174|UniProtKB=T1G1B1 T1G1B1 20214859 PTHR11093:SF2 RUVB-RELATED REPTIN AND PONTIN RUVB-LIKE 2 ATP-dependent activity, acting on DNA#GO:0008094;catalytic activity, acting on a nucleic acid#GO:0140640;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;protein-RNA complex assembly#GO:0022618;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of biosynthetic process#GO:0009889;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;ribonucleoprotein complex biogenesis#GO:0022613;biological regulation#GO:0065007;chromatin organization#GO:0006325;protein-RNA complex organization#GO:0071826;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 Ino80 complex#GO:0031011;histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;NuA4 histone acetyltransferase complex#GO:0035267;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;non-membrane-bounded organelle#GO:0043228;chromosome#GO:0005694;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;protein-DNA complex#GO:0032993;transferase complex#GO:1990234;INO80-type complex#GO:0097346;intracellular organelle lumen#GO:0070013;ATPase complex#GO:1904949;SWI/SNF superfamily-type complex#GO:0070603;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;histone deacetylase complex#GO:0000118;nuclear lumen#GO:0031981;Swr1 complex#GO:0000812;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG179809|UniProtKB=T1FF64 T1FF64 20207463 PTHR45784:SF5 C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED HELRO|EnsemblGenome=HelroG162562|UniProtKB=T1ESU3 T1ESU3 20199643 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG114638|UniProtKB=T1EG36 T1EG36 20195538 PTHR12546:SF60 FER-1-LIKE MISFIRE, ISOFORM F endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cellular process#GO:0009987;membrane organization#GO:0061024;plasma membrane organization#GO:0007009 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG177755|UniProtKB=T1FC72 T1FC72 20206421 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG194939|UniProtKB=T1FWL4 T1FWL4 20213209 PTHR10165:SF103 LIPID PHOSPHATE PHOSPHATASE PHOSPHOLIPID PHOSPHATASE HOMOLOG 1.2 HOMOLOG hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 phospholipid dephosphorylation#GO:0046839;lipid metabolic process#GO:0006629;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;cellular metabolic process#GO:0044237;cell communication#GO:0007154;lipid modification#GO:0030258;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;dephosphorylation#GO:0016311;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG168105|UniProtKB=T1F062 T1F062 20202212 PTHR28597:SF1 VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT-ASSOCIATED REGULATORY PROTEIN VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT-ASSOCIATED REGULATORY PROTEIN protein binding#GO:0005515;transmembrane transporter binding#GO:0044325;binding#GO:0005488 regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;negative regulation of biological process#GO:0048519;regulation of metal ion transport#GO:0010959;regulation of secretion by cell#GO:1903530;regulation of calcium ion transport#GO:0051924;regulation of localization#GO:0032879;negative regulation of transport#GO:0051051;regulation of monoatomic cation transmembrane transport#GO:1904062;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of transport#GO:0051049;regulation of molecular function#GO:0065009;regulation of cellular process#GO:0050794;regulation of secretion#GO:0051046;negative regulation of monoatomic ion transport#GO:0043271;biological regulation#GO:0065007;regulation of monoatomic ion transmembrane transporter activity#GO:0032412;regulation of monoatomic ion transport#GO:0043269;regulation of transmembrane transporter activity#GO:0022898;regulation of transporter activity#GO:0032409;negative regulation of cellular process#GO:0048523;regulation of exocytosis#GO:0017157;negative regulation of molecular function#GO:0044092 intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;secretory granule#GO:0030141;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;secretory vesicle#GO:0099503;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG77182|UniProtKB=T1G2U2 T1G2U2 20215390 PTHR12804:SF0 MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23 SIGNAL PEPTIDASE COMPLEX SUBUNIT 3 cellular localization#GO:0051641;macromolecule localization#GO:0033036;peptide metabolic process#GO:0006518;gene expression#GO:0010467;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;protein processing#GO:0016485;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein localization to organelle#GO:0033365;establishment of protein localization to endoplasmic reticulum#GO:0072599;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;protein localization to endoplasmic reticulum#GO:0070972;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein targeting#GO:0006605;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;establishment of protein localization to organelle#GO:0072594;protein targeting to ER#GO:0045047;protein maturation#GO:0051604;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;cellular macromolecule localization#GO:0070727;signal peptide processing#GO:0006465 membrane protein complex#GO:0098796;peptidase complex#GO:1905368;endoplasmic reticulum protein-containing complex#GO:0140534;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 protease#PC00190;protein modifying enzyme#PC00260 Vasopressin synthesis#P04395>Signal Peptidase#P04589 HELRO|EnsemblGenome=HelroG193990|UniProtKB=T1FVJ8 T1FVJ8 20212844 PTHR12358:SF31 SPHINGOSINE KINASE ACYLGLYCEROL KINASE, MITOCHONDRIAL transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;lipid kinase activity#GO:0001727 organic hydroxy compound metabolic process#GO:1901615;lipid metabolic process#GO:0006629;alcohol biosynthetic process#GO:0046165;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic hydroxy compound biosynthetic process#GO:1901617;alcohol metabolic process#GO:0006066;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;membrane lipid biosynthetic process#GO:0046467;sphingolipid metabolic process#GO:0006665;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;membrane lipid metabolic process#GO:0006643;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;phosphorylation#GO:0016310;small molecule biosynthetic process#GO:0044283;cellular lipid metabolic process#GO:0044255;sphingolipid biosynthetic process#GO:0030148;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 kinase#PC00137 HELRO|EnsemblGenome=HelroG181398|UniProtKB=T1FGY8 T1FGY8 20208087 PTHR24064:SF577 SOLUTE CARRIER FAMILY 22 MEMBER GH09241P secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG178210|UniProtKB=T1FCY1 T1FCY1 20206680 PTHR33244:SF3 INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED PEPTIDASE A2 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG101948|UniProtKB=T1ED76 T1ED76 20194528 PTHR11732:SF506 ALDO/KETO REDUCTASE ALDO-KETO REDUCTASE 1B, ISOFORM C-RELATED oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG167602|UniProtKB=T1EZJ3 T1EZJ3 20201993 PTHR22770:SF47 UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED E3 UBIQUITIN-PROTEIN LIGASE RNF216 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG63014|UniProtKB=T1FX98 T1FX98 20213446 PTHR45987:SF4 39S RIBOSOMAL PROTEIN L12 LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;translation#GO:0006412;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG72035|UniProtKB=T1G0U3 T1G0U3 20214691 PTHR13780:SF35 AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT LD22662P kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG78591|UniProtKB=T1G3D5 T1G3D5 20215583 PTHR12782:SF5 MICROSOMAL PROSTAGLANDIN E SYNTHASE-2 PROSTAGLANDIN E SYNTHASE 2 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 reductase#PC00198;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG146217|UniProtKB=T1EJQ9 T1EJQ9 20196809 PTHR24416:SF564 TYROSINE-PROTEIN KINASE RECEPTOR MACROPHAGE-STIMULATING PROTEIN RECEPTOR signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;nervous system development#GO:0007399;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;system development#GO:0048731;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cell motility#GO:0048870;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;cell migration#GO:0016477;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG155844|UniProtKB=T1ELN2 T1ELN2 20197482 PTHR45896:SF1 N-ALPHA-ACETYLTRANSFERASE 30 N-ALPHA-ACETYLTRANSFERASE 30 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acetyltransferase activity#GO:0016407;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;peptide alpha-N-acetyltransferase activity#GO:0004596;N-acyltransferase activity#GO:0016410 cytoplasm#GO:0005737;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;acetyltransferase complex#GO:1902493;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG145344|UniProtKB=T1EJK2 T1EJK2 20196752 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG81592|UniProtKB=T1G4G1 T1G4G1 20215959 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;heme binding#GO:0020037 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG86324|UniProtKB=T1G6A4 T1G6A4 20216601 PTHR10755:SF0 COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 tetrapyrrole metabolic process#GO:0033013;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;pigment metabolic process#GO:0042440;porphyrin-containing compound metabolic process#GO:0006778;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;heme biosynthetic process#GO:0006783;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;pigment biosynthetic process#GO:0046148;aromatic compound biosynthetic process#GO:0019438;organic substance metabolic process#GO:0071704;heme metabolic process#GO:0042168;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 oxidase#PC00175;oxidoreductase#PC00176 Heme biosynthesis#P02746>Coproporphyrinogen Oxidase (oxygen dependent)#P02980 HELRO|EnsemblGenome=HelroG193646|UniProtKB=T1FV80 T1FV80 20212726 PTHR10183:SF433 CALPAIN CALPAIN-A-RELATED cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protease#PC00190 Huntington disease#P00029>Calpain#P00788 HELRO|EnsemblGenome=HelroG188439|UniProtKB=T1FPZ6 T1FPZ6 20210893 PTHR23339:SF27 TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE PROTEIN-TYROSINE-PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 regulation of mitotic cell cycle phase transition#GO:1901990;microtubule cytoskeleton organization#GO:0000226;regulation of cell cycle phase transition#GO:1901987;positive regulation of cell cycle#GO:0045787;cellular component organization#GO:0016043;regulation of cell division#GO:0051302;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;regulation of cell cycle process#GO:0010564;regulation of biological process#GO:0050789;positive regulation of cell division#GO:0051781;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;positive regulation of cell cycle process#GO:0090068;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of cell cycle#GO:0051726;regulation of cytokinesis#GO:0032465;regulation of mitotic cell cycle#GO:0007346;positive regulation of biological process#GO:0048518 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG167566|UniProtKB=T1EZH9 T1EZH9 20201979 PTHR13339:SF0 COP9 SIGNALOSOME COMPLEX SUBUNIT 8 COP9 SIGNALOSOME COMPLEX SUBUNIT 8 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG106865|UniProtKB=T1EE53 T1EE53 20194855 PTHR12300:SF161 HVA22-LIKE PROTEINS RECEPTOR EXPRESSION-ENHANCING PROTEIN membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG70377|UniProtKB=T1G057 T1G057 20214455 PTHR43601:SF3 THIOREDOXIN, MITOCHONDRIAL THIOREDOXIN, MITOCHONDRIAL homeostatic process#GO:0042592;cellular homeostasis#GO:0019725 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 Hypoxia response via HIF activation#P00030>Thioredoxin#P00825 HELRO|EnsemblGenome=HelroG184648|UniProtKB=T1FLN8 T1FLN8 20209737 PTHR46273:SF4 MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED AT19640P signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG165867|UniProtKB=T1EXD7 T1EXD7 20201237 PTHR46447:SF1 INTERLEUKIN ENHANCER-BINDING FACTOR INTERLEUKIN ENHANCER-BINDING FACTOR 2 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;double-stranded RNA binding#GO:0003725;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 ribonucleoprotein complex#GO:1990904;catalytic step 2 spliceosome#GO:0071013;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG113493|UniProtKB=T1EFS9 T1EFS9 20195431 PTHR10067:SF6 PHOSPHATIDYLSERINE DECARBOXYLASE PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL lyase activity#GO:0016829;carboxy-lyase activity#GO:0016831;carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;glycerophospholipid metabolic process#GO:0006650;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;primary metabolic process#GO:0044238;glycerolipid metabolic process#GO:0046486;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 decarboxylase#PC00089 HELRO|EnsemblGenome=HelroG79952|UniProtKB=T1G3V6 T1G3V6 20215754 PTHR24637:SF422 COLLAGEN COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG84464|UniProtKB=T1G5I9 T1G5I9 20216336 PTHR23086:SF8 PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301;lipid kinase activity#GO:0001727 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 kinase#PC00137 HELRO|EnsemblGenome=HelroG75190|UniProtKB=T1G224 T1G224 20215122 PTHR11575:SF24 5'-NUCLEOTIDASE-RELATED 5'-NUCLEOTIDASE phosphodiesterase#PC00185;metabolite interconversion enzyme#PC00262 Pyrimidine Metabolism#P02771>5'-Nucleotidase#P03131;Purine metabolism#P02769>5'-Nucleotidase#P03119 HELRO|EnsemblGenome=HelroG186253|UniProtKB=T1FNV5 T1FNV5 20210502 PTHR15975:SF0 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11 CCR4-NOT complex#GO:0030014;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG94219|UniProtKB=T1G8Z4 T1G8Z4 20217541 PTHR11632:SF51 SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG65617|UniProtKB=T1FYA7 T1FYA7 20213805 PTHR24353:SF153 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;cytosol#GO:0005829;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Enkephalin release#P05913>PKA#P05972;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Endothelin signaling pathway#P00019>PKA#P00570;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059 HELRO|EnsemblGenome=HelroG154629|UniProtKB=T1ELF4 T1ELF4 20197404 PTHR12806:SF0 EAP30 SUBUNIT OF ELL COMPLEX VACUOLAR-SORTING PROTEIN SNF8 endosomal transport#GO:0016197;cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;protein catabolic process#GO:0030163;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;nitrogen compound transport#GO:0071705;organonitrogen compound catabolic process#GO:1901565;late endosome to vacuole transport#GO:0045324;protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043328;establishment of protein localization#GO:0045184;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;modification-dependent macromolecule catabolic process#GO:0043632;organic substance transport#GO:0071702;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein localization to organelle#GO:0033365;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;establishment of protein localization to vacuole#GO:0072666;modification-dependent protein catabolic process#GO:0019941;vacuolar transport#GO:0007034;macromolecule metabolic process#GO:0043170;protein localization to vacuole#GO:0072665;organonitrogen compound metabolic process#GO:1901564;establishment of protein localization to organelle#GO:0072594;vesicle-mediated transport#GO:0016192;multivesicular body sorting pathway#GO:0071985;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein localization#GO:0008104;ubiquitin-dependent protein catabolic process#GO:0006511;localization#GO:0051179;cellular macromolecule localization#GO:0070727;protein transport#GO:0015031;endosome transport via multivesicular body sorting pathway#GO:0032509;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endosome membrane#GO:0010008;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cytoplasmic vesicle membrane#GO:0030659 HELRO|EnsemblGenome=HelroG190440|UniProtKB=T1FRZ9 T1FRZ9 20211596 PTHR43272:SF83 LONG-CHAIN-FATTY-ACID--COA LIGASE ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J long-chain fatty acid-CoA ligase activity#GO:0004467;ligase activity#GO:0016874;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG187823|UniProtKB=T1FPE6 T1FPE6 20210693 PTHR15829:SF13 PROTEIN KINASE PKN/PRK1, EFFECTOR FAM65 N-TERMINAL DOMAIN-CONTAINING PROTEIN non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG185806|UniProtKB=T1FNB3 T1FNB3 20210310 PTHR31019:SF1 SMALL INTEGRAL MEMBRANE PROTEIN 14 SMALL INTEGRAL MEMBRANE PROTEIN 14 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG159014|UniProtKB=T1ENH5 T1ENH5 20198125 PTHR37018:SF1 CULTURE SPECIFIC PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00130)-RELATED CULTURE SPECIFIC PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00130)-RELATED HELRO|EnsemblGenome=HelroG189902|UniProtKB=T1FRG7 T1FRG7 20211414 PTHR12873:SF0 T7-LIKE MITOCHONDRIAL DNA HELICASE TWINKLE MTDNA HELICASE ATP-dependent activity, acting on DNA#GO:0008094;nucleic acid binding#GO:0003676;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;single-stranded DNA binding#GO:0003697;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;catalytic activity, acting on a nucleic acid#GO:0140640;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097 DNA helicase#PC00011;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG155611|UniProtKB=T1ELJ6 T1ELJ6 20197446 PTHR22780:SF5 ADAPTIN, ALPHA/GAMMA/EPSILON AP-1 COMPLEX SUBUNIT GAMMA molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 localization#GO:0051179;cellular localization#GO:0051641;Golgi to vacuole transport#GO:0006896;establishment of localization#GO:0051234;vacuolar transport#GO:0007034;post-Golgi vesicle-mediated transport#GO:0006892;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987 bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;clathrin vesicle coat#GO:0030125;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;AP-type membrane coat adaptor complex#GO:0030119;transport vesicle membrane#GO:0030658;clathrin-coated vesicle#GO:0030136;membrane coat#GO:0030117;coated membrane#GO:0048475;cytoplasmic vesicle membrane#GO:0030659;trans-Golgi network transport vesicle#GO:0030140;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;membrane#GO:0016020;coated vesicle#GO:0030135;vesicle coat#GO:0030120;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;Golgi-associated vesicle membrane#GO:0030660;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;coated vesicle membrane#GO:0030662;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;Golgi-associated vesicle#GO:0005798;transport vesicle#GO:0030133 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG182183|UniProtKB=T1FHW1 T1FHW1 20208410 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163951|UniProtKB=T1EUN3 T1EUN3 20200283 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG125265|UniProtKB=T1EH53 T1EH53 20195903 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED single-stranded RNA binding#GO:0003727;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;poly(A) binding#GO:0008143;binding#GO:0005488;organic cyclic compound binding#GO:0097159 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG173681|UniProtKB=T1F741 T1F741 20204640 PTHR10281:SF72 MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED NEUDESIN cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG185811|UniProtKB=T1FNB7 T1FNB7 20210314 PTHR10598:SF0 SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2 SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 membrane-enclosed lumen#GO:0031974;histone methyltransferase complex#GO:0035097;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;methyltransferase complex#GO:0034708;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;Set1C/COMPASS complex#GO:0048188;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG165437|UniProtKB=T1EWS6 T1EWS6 20201026 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG63060|UniProtKB=T1FXA5 T1FXA5 20213453 PTHR43015:SF1 D-RIBITOL-5-PHOSPHATE CYTIDYLYLTRANSFERASE D-RIBITOL-5-PHOSPHATE CYTIDYLYLTRANSFERASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG90241|UniProtKB=T1G7N0 T1G7N0 20217077 PTHR18945:SF856 NEUROTRANSMITTER GATED ION CHANNEL GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA signaling receptor activity#GO:0038023;inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;molecular transducer activity#GO:0060089;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;transmembrane signaling receptor activity#GO:0004888 localization#GO:0051179;inorganic anion transmembrane transport#GO:0098661;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic anion transport#GO:0006820;chloride transport#GO:0006821;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;inorganic anion transport#GO:0015698 receptor complex#GO:0043235;protein-containing complex#GO:0032991 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG187944|UniProtKB=T1FPH7 T1FPH7 20210724 PTHR13140:SF713 MYOSIN UNCONVENTIONAL MYOSIN ID microfilament motor activity#GO:0000146;cytoskeletal protein binding#GO:0008092;ATP-dependent activity#GO:0140657;binding#GO:0005488;actin filament binding#GO:0051015;cytoskeletal motor activity#GO:0003774;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779 actin filament-based movement#GO:0030048;transport#GO:0006810;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;establishment of localization#GO:0051234;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;import into cell#GO:0098657 microvillus#GO:0005902;actin-based cell projection#GO:0098858;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cell projection#GO:0042995;plasma membrane#GO:0005886 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG75748|UniProtKB=T1G296 T1G296 20215194 PTHR12875:SF0 GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG localization within membrane#GO:0051668;protein insertion into ER membrane#GO:0045048;cellular localization#GO:0051641;endoplasmic reticulum organization#GO:0007029;macromolecule localization#GO:0033036;membrane organization#GO:0061024;protein localization to membrane#GO:0072657;endomembrane system organization#GO:0010256;cellular component organization#GO:0016043;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to membrane#GO:0090150;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;organelle organization#GO:0006996;protein localization to organelle#GO:0033365;protein insertion into membrane#GO:0051205 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG92217|UniProtKB=T1G8D0 T1G8D0 20217327 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG92371|UniProtKB=T1G8F2 T1G8F2 20217349 PTHR24185:SF1 CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;phospholipase activity#GO:0004620;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;oxoacid metabolic process#GO:0043436;fatty acid metabolic process#GO:0006631;cellular metabolic process#GO:0044237;cellular process#GO:0009987;cellular lipid metabolic process#GO:0044255;organic acid metabolic process#GO:0006082;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;membrane#GO:0016020 phospholipase#PC00186;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG161462|UniProtKB=T1ERH9 T1ERH9 20199179 PTHR11804:SF79 PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED MITOCHONDRIAL INTERMEDIATE PEPTIDASE hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;peptide metabolic process#GO:0006518;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG91349|UniProtKB=T1G828 T1G828 20217225 PTHR48021:SF1 FAMILY NOT NAMED GH07001P-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG95543|UniProtKB=T1G967 T1G967 20217614 PTHR14136:SF17 BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD9 BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD9 HELRO|EnsemblGenome=HelroG177887|UniProtKB=T1FCF3 T1FCF3 20206502 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG109728|UniProtKB=T1EEW0 T1EEW0 20195112 PTHR24335:SF4 MOTOR NEURON AND PANCREAS HOMEOBOX PROTEIN EXTRA-EXTRA sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 cellular developmental process#GO:0048869;neurogenesis#GO:0022008;cell projection organization#GO:0030030;developmental process#GO:0032502;multicellular organism development#GO:0007275;cell morphogenesis#GO:0000902;cell projection morphogenesis#GO:0048858;cellular component organization#GO:0016043;nervous system development#GO:0007399;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;cell differentiation#GO:0030154;system development#GO:0048731;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;neuron projection morphogenesis#GO:0048812;neuron development#GO:0048666;central nervous system development#GO:0007417;plasma membrane bounded cell projection morphogenesis#GO:0120039;generation of neurons#GO:0048699 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG188796|UniProtKB=T1FQD3 T1FQD3 20211030 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG123894|UniProtKB=T1EGZ5 T1EGZ5 20195845 PTHR23050:SF536 CALCIUM BINDING PROTEIN EF-HAND DOMAIN-CONTAINING PROTEIN cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 calmodulin-related#PC00061 B cell activation#P00010>Calmodulin#P00375;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Calmodulin#P00755;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716;T cell activation#P00053>Calmodulin#P01305 HELRO|EnsemblGenome=HelroG106340|UniProtKB=T1EE22 T1EE22 20194824 PTHR24204:SF8 INSULIN GENE ENHANCER PROTEIN TAILUP, ISOFORM A cellular developmental process#GO:0048869;neurogenesis#GO:0022008;cell projection organization#GO:0030030;multicellular organism development#GO:0007275;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;cell morphogenesis#GO:0000902;cellular component organization#GO:0016043;cell fate commitment#GO:0045165;cellular process#GO:0009987;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;cell fate specification#GO:0001708;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;cell differentiation#GO:0030154;system development#GO:0048731;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;neuron differentiation#GO:0030182;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;axonogenesis#GO:0007409;plasma membrane bounded cell projection morphogenesis#GO:0120039;generation of neurons#GO:0048699 HELRO|EnsemblGenome=HelroG188730|UniProtKB=T1FQB1 T1FQB1 20211008 PTHR21284:SF12 EG:80H7.2 PROTEIN EG:80H7.2 PROTEIN HELRO|EnsemblGenome=HelroG154695|UniProtKB=T1ELF7 T1ELF7 20197407 PTHR46207:SF1 PROTEIN RCC2 PROTEIN RCC2 enzyme binding#GO:0019899;protein binding#GO:0005515;small GTPase binding#GO:0031267;binding#GO:0005488 regulation of biological process#GO:0050789;negative regulation of hydrolase activity#GO:0051346;negative regulation of biological process#GO:0048519;regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087;biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;negative regulation of catalytic activity#GO:0043086;negative regulation of molecular function#GO:0044092 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG91961|UniProtKB=T1G8A9 T1G8A9 20217306 PTHR18952:SF208 CARBONIC ANHYDRASE CARBONIC ANHYDRASE XA-RELATED carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 cellular metabolic process#GO:0044237;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG89170|UniProtKB=T1G795 T1G795 20216942 PTHR18849:SF0 LEUCINE RICH REPEAT PROTEIN CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 410-RELATED HELRO|EnsemblGenome=HelroG63476|UniProtKB=T1FXG4 T1FXG4 20213512 PTHR16083:SF83 LEUCINE RICH REPEAT CONTAINING PROTEIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN 40 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG115899|UniProtKB=T1EGB5 T1EGB5 20195617 PTHR12743:SF0 CYTOCHROME C1 HEME LYASE HOLOCYTOCHROME C-TYPE SYNTHASE lyase activity#GO:0016829;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein-containing complex assembly#GO:0065003;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular component organization#GO:0016043;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nitrogen compound metabolic process#GO:0006807;protein-containing complex organization#GO:0043933;cytochrome complex assembly#GO:0017004;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 lyase#PC00144 HELRO|EnsemblGenome=HelroG65938|UniProtKB=T1FYE6 T1FYE6 20213844 PTHR23064:SF32 TROPONIN CALTRACTIN ICL1F cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG173603|UniProtKB=T1F709 T1F709 20204608 PTHR46601:SF1 ULP_PROTEASE DOMAIN-CONTAINING PROTEIN ADF-H DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193953|UniProtKB=T1FVI6 T1FVI6 20212832 PTHR19139:SF199 AQUAPORIN TRANSPORTER MIP17260P cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG173357|UniProtKB=T1F6Q3 T1F6Q3 20204502 PTHR11362:SF82 PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4 protease inhibitor#PC00191 EGF receptor signaling pathway#P00018>RKIP#P00548;FGF signaling pathway#P00021>RKIP#P00630 HELRO|EnsemblGenome=HelroG92779|UniProtKB=T1G8K9 T1G8K9 20217406 PTHR22957:SF27 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 13 nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 cellular localization#GO:0051641;macromolecule localization#GO:0033036;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;transport#GO:0006810;activation of GTPase activity#GO:0090630;positive regulation of molecular function#GO:0044093;nitrogen compound transport#GO:0071705;regulation of catalytic activity#GO:0050790;cellular process#GO:0009987;establishment of protein localization#GO:0045184;positive regulation of hydrolase activity#GO:0051345;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;regulation of molecular function#GO:0065009;protein transport#GO:0015031;biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG98900|UniProtKB=T1G9Q2 T1G9Q2 20217798 PTHR10529:SF262 AP COMPLEX SUBUNIT MU ADAPTOR PROTEIN COMPLEX 1, MU SUBUNIT localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;transport#GO:0006810 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG185801|UniProtKB=T1FNB0 T1FNB0 20210307 PTHR31965:SF1 TRANSMEMBRANE PROTEIN 42 TRANSMEMBRANE PROTEIN 42 HELRO|EnsemblGenome=HelroG63272|UniProtKB=T1FXD4 T1FXD4 20213482 PTHR23074:SF78 AAA DOMAIN-CONTAINING KATANIN P60 ATPASE-CONTAINING SUBUNIT A-LIKE 2 pyrophosphatase activity#GO:0016462;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG160345|UniProtKB=T1EQ45 T1EQ45 20198695 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG88222|UniProtKB=T1G701 T1G701 20216848 PTHR10390:SF61 HOMEOBOX PROTEIN SIX HOMEOBOX PROTEIN SIX2 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG178849|UniProtKB=T1FDT6 T1FDT6 20206985 PTHR23279:SF36 DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED DEFECTIVE PROBOSCIS EXTENSION RESPONSE 9, ISOFORM A cellular component organization or biogenesis#GO:0071840;synapse organization#GO:0050808;cellular component organization#GO:0016043;cellular process#GO:0009987;cell junction organization#GO:0034330 cell leading edge#GO:0031252;neuron projection#GO:0043005;leading edge membrane#GO:0031256;plasma membrane region#GO:0098590;cell projection membrane#GO:0031253;cell projection#GO:0042995;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG157196|UniProtKB=T1EM78 T1EM78 20197678 PTHR23055:SF167 CALCIUM BINDING PROTEINS EF-HAND DOMAIN-CONTAINING PROTEIN cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG121515|UniProtKB=T1EGS2 T1EGS2 20195772 PTHR11003:SF334 POTASSIUM CHANNEL, SUBFAMILY K FI03418P monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG108152|UniProtKB=T1EEG0 T1EEG0 20194962 PTHR31661:SF1 SIMILAR TO CDNA SEQUENCE BC052040 CDAN1-INTERACTING NUCLEASE 1 HELRO|EnsemblGenome=HelroG159811|UniProtKB=T1EPF2 T1EPF2 20198452 PTHR22914:SF42 CHITIN SYNTHASE CHITIN SYNTHASE acetylglucosaminyltransferase activity#GO:0008375;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758 carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;aminoglycan biosynthetic process#GO:0006023;amino sugar metabolic process#GO:0006040;aminoglycan metabolic process#GO:0006022;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;cell septum#GO:0030428 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG86632|UniProtKB=T1G6E7 T1G6E7 20216644 PTHR11909:SF20 CASEIN KINASE-RELATED CASEIN KINASE I ISOFORM ALPHA transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Hedgehog signaling pathway#P00025>Casein kinase I#P00681;Parkinson disease#P00049>Casein kinase I#P01242 HELRO|EnsemblGenome=HelroG160080|UniProtKB=T1EPR2 T1EPR2 20198562 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG65661|UniProtKB=T1FYB3 T1FYB3 20213811 PTHR11132:SF255 SOLUTE CARRIER FAMILY 35 GDP-FUCOSE TRANSPORTER 1 secondary active transmembrane transporter activity#GO:0015291;antiporter activity#GO:0015297;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG174405|UniProtKB=T1F833 T1F833 20204982 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG192938|UniProtKB=T1FUF8 T1FUF8 20212454 PTHR23119:SF44 DISCS LARGE PROTEIN LAP4 enzyme binding#GO:0019899;protein binding#GO:0005515;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900 establishment or maintenance of cell polarity#GO:0007163;localization within membrane#GO:0051668;cellular localization#GO:0051641;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;developmental process#GO:0032502;multicellular organism development#GO:0007275;cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987;protein localization#GO:0008104;localization#GO:0051179;embryo development#GO:0009790;cellular macromolecule localization#GO:0070727;anatomical structure development#GO:0048856;establishment or maintenance of apical/basal cell polarity#GO:0035088;multicellular organismal process#GO:0032501;receptor clustering#GO:0043113;establishment or maintenance of bipolar cell polarity#GO:0061245;protein-containing complex localization#GO:0031503 basal plasma membrane#GO:0009925;anchoring junction#GO:0070161;cell-cell junction#GO:0005911;basolateral plasma membrane#GO:0016323;cell junction#GO:0030054;plasma membrane region#GO:0098590;adherens junction#GO:0005912;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;basal part of cell#GO:0045178;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG90119|UniProtKB=T1G7L3 T1G7L3 20217060 PTHR22734:SF2 U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4 U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4 snoRNA binding#GO:0030515;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981;90S preribosome#GO:0030686;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG184583|UniProtKB=T1FLJ0 T1FLJ0 20209689 PTHR46601:SF1 ULP_PROTEASE DOMAIN-CONTAINING PROTEIN ADF-H DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193766|UniProtKB=T1FVC2 T1FVC2 20212768 PTHR13271:SF34 UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE N-LYSINE METHYLTRANSFERASE SETD6 N-methyltransferase activity#GO:0008170;transferase activity#GO:0016740;catalytic activity#GO:0003824;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;protein-lysine N-methyltransferase activity#GO:0016279;catalytic activity, acting on a protein#GO:0140096;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein methyltransferase activity#GO:0008276;lysine N-methyltransferase activity#GO:0016278 macromolecule methylation#GO:0043414;methylation#GO:0032259;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;primary metabolic process#GO:0044238 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transferase#PC00220;methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG184989|UniProtKB=T1FM85 T1FM85 20209934 PTHR11703:SF0 DEOXYHYPUSINE SYNTHASE DEOXYHYPUSINE SYNTHASE transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;peptidyl-amino acid modification#GO:0018193;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG77175|UniProtKB=T1G2U0 T1G2U0 20215388 PTHR12281:SF32 RP42 RELATED DCN1-LIKE PROTEIN cullin family protein binding#GO:0097602;enzyme binding#GO:0019899;ubiquitin-like protein conjugating enzyme binding#GO:0044390;protein binding#GO:0005515;ubiquitin-like protein binding#GO:0032182;binding#GO:0005488 protein neddylation#GO:0045116;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG174531|UniProtKB=T1F882 T1F882 20205031 PTHR36960:SF1 SI:DKEY-32E6.3 SI:DKEY-32E6.3 HELRO|EnsemblGenome=HelroG63815|UniProtKB=T1FXK8 T1FXK8 20213556 PTHR10585:SF14 ER LUMEN PROTEIN RETAINING RECEPTOR ER LUMEN PROTEIN-RETAINING RECEPTOR signal sequence binding#GO:0005048;binding#GO:0005488;amide binding#GO:0033218;peptide binding#GO:0042277 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;protein localization to endoplasmic reticulum#GO:0070972;macromolecule localization#GO:0033036;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;protein localization#GO:0008104;localization#GO:0051179;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;maintenance of location#GO:0051235;maintenance of location in cell#GO:0051651;establishment of localization in cell#GO:0051649;protein localization to organelle#GO:0033365;intracellular transport#GO:0046907 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cis-Golgi network#GO:0005801;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG168748|UniProtKB=T1F0X1 T1F0X1 20202471 PTHR23354:SF62 NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED MUSTARD, ISOFORM V HELRO|EnsemblGenome=HelroG181811|UniProtKB=T1FHD0 T1FHD0 20208229 PTHR19303:SF71 TRANSPOSON ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG67205|UniProtKB=T1FYY1 T1FYY1 20214029 PTHR15045:SF1 FUCOSE-1-PHOSPHATE GUANYLYLTRANSFERASE FUCOSE-1-PHOSPHATE GUANYLYLTRANSFERASE transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG168497|UniProtKB=T1F0N0 T1F0N0 20202380 PTHR46674:SF1 INACTIVE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP6 INACTIVE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP6 chaperone#PC00072 HELRO|EnsemblGenome=HelroG185182|UniProtKB=T1FMH3 T1FMH3 20210022 PTHR10333:SF42 INHIBITOR OF GROWTH PROTEIN INHIBITOR OF GROWTH PROTEIN 5 protein binding#GO:0005515;methylated histone binding#GO:0035064;binding#GO:0005488;histone binding#GO:0042393;modification-dependent protein binding#GO:0140030 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG164330|UniProtKB=T1EV95 T1EV95 20200495 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG180074|UniProtKB=T1FFG1 T1FFG1 20207560 PTHR19325:SF575 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING LOCOMOTION-RELATED PROTEIN HIKARU GENKI complement component#PC00078 HELRO|EnsemblGenome=HelroG156498|UniProtKB=T1ELX6 T1ELX6 20197576 PTHR47958:SF26 ATP-DEPENDENT RNA HELICASE DBP3 EUKARYOTIC INITIATION FACTOR 4A-III catalytic activity, acting on RNA#GO:0140098;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640;mRNA binding#GO:0003729 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;mRNA splicing, via spliceosome#GO:0000398;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;catalytic step 2 spliceosome#GO:0071013;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG110400|UniProtKB=T1EF19 T1EF19 20195171 PTHR10921:SF1 NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1 NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 vesicle transport along microtubule#GO:0047496;establishment or maintenance of cell polarity#GO:0007163;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;organelle localization#GO:0051640;nuclear division#GO:0000280;transport#GO:0006810;establishment of spindle orientation#GO:0051294;cell cycle process#GO:0022402;microtubule-based movement#GO:0007018;microtubule cytoskeleton organization#GO:0000226;protein-containing complex assembly#GO:0065003;centrosome cycle#GO:0007098;microtubule cytoskeleton organization involved in mitosis#GO:1902850;microtubule polymerization or depolymerization#GO:0031109;mitotic cell cycle process#GO:1903047;chromosome segregation#GO:0007059;establishment of cell polarity#GO:0030010;mitotic cell cycle#GO:0000278;microtubule polymerization#GO:0046785;establishment of localization#GO:0051234;establishment of vesicle localization#GO:0051650;supramolecular fiber organization#GO:0097435;cytoskeleton-dependent intracellular transport#GO:0030705;cytoskeleton organization#GO:0007010;mitotic nuclear division#GO:0140014;establishment of organelle localization#GO:0051656;spindle localization#GO:0051653;cellular component assembly#GO:0022607;establishment of chromosome localization#GO:0051303;vesicle localization#GO:0051648;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule organizing center organization#GO:0031023;establishment of spindle localization#GO:0051293;transport along microtubule#GO:0010970;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of mitotic spindle localization#GO:0040001;establishment of mitotic spindle orientation#GO:0000132;microtubule-based transport#GO:0099111;microtubule-based process#GO:0007017;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;centrosome localization#GO:0051642;protein polymerization#GO:0051258;cell cycle#GO:0007049;establishment of localization in cell#GO:0051649;organelle fission#GO:0048285;intracellular transport#GO:0046907;chromosome localization#GO:0050000;microtubule nucleation#GO:0007020;organelle transport along microtubule#GO:0072384;vesicle cytoskeletal trafficking#GO:0099518 supramolecular complex#GO:0099080;microtubule organizing center#GO:0005815;kinetochore#GO:0000776;condensed chromosome, centromeric region#GO:0000779;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;centrosome#GO:0005813;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;chromosome#GO:0005694;microtubule cytoskeleton#GO:0015630;chromosomal region#GO:0098687;cytoskeleton#GO:0005856 HELRO|EnsemblGenome=HelroG174847|UniProtKB=T1F8J3 T1F8J3 20205142 PTHR13526:SF8 TRANSCRIPTION FACTOR SPT20 HOMOLOG TRANSCRIPTION FACTOR SPT20 HOMOLOG molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 SAGA-type complex#GO:0070461;peptidase complex#GO:1905368;histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;chromosome#GO:0005694;SAGA complex#GO:0000124 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG174841|UniProtKB=T1F8J1 T1F8J1 20205140 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG79167|UniProtKB=T1G3L1 T1G3L1 20215659 PTHR12829:SF7 N6-ADENOSINE-METHYLTRANSFERASE N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT RNA metabolism protein#PC00031;RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG178793|UniProtKB=T1FDR1 T1FDR1 20206960 PTHR11431:SF75 FERRITIN FERRITIN cation binding#GO:0043169;ferrous iron binding#GO:0008198;small molecule binding#GO:0036094;binding#GO:0005488;iron ion binding#GO:0005506;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;ion binding#GO:0043167 localization#GO:0051179;inorganic ion homeostasis#GO:0098771;cellular localization#GO:0051641;intracellular iron ion homeostasis#GO:0006879;maintenance of location#GO:0051235;maintenance of location in cell#GO:0051651;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;chemical homeostasis#GO:0048878;cellular process#GO:0009987;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 storage protein#PC00210 HELRO|EnsemblGenome=HelroG161584|UniProtKB=T1ERN4 T1ERN4 20199234 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182905|UniProtKB=T1FIW9 T1FIW9 20208768 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG105878|UniProtKB=T1EDY2 T1EDY2 20194784 PTHR10555:SF170 SORTING NEXIN FI18122P1 lipid binding#GO:0008289;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;binding#GO:0005488 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG161972|UniProtKB=T1ES40 T1ES40 20199390 PTHR43020:SF2 CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 1 MITOCHONDRIAL TRNA METHYLTHIOTRANSFERASE CDK5RAP1 transferase activity#GO:0016740;transferase activity, transferring sulphur-containing groups#GO:0016782;small molecule binding#GO:0036094;iron-sulfur cluster binding#GO:0051536;binding#GO:0005488;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 HELRO|EnsemblGenome=HelroG100443|UniProtKB=T1ECZ8 T1ECZ8 20194450 PTHR45615:SF40 MYOSIN HEAVY CHAIN, NON-MUSCLE MYOSIN HEAVY CHAIN, NON-MUSCLE microfilament motor activity#GO:0000146;cytoskeletal protein binding#GO:0008092;ATP-dependent activity#GO:0140657;binding#GO:0005488;actin filament binding#GO:0051015;cytoskeletal motor activity#GO:0003774;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779 supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;supramolecular fiber#GO:0099512;supramolecular polymer#GO:0099081;myosin complex#GO:0016459;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Myosin#P00867;Cytoskeletal regulation by Rho GTPase#P00016>Myosin#P00522;Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG189774|UniProtKB=T1FRD2 T1FRD2 20211379 PTHR46424:SF1 UBX DOMAIN-CONTAINING PROTEIN 4 UBX DOMAIN-CONTAINING PROTEIN 4 response to organic substance#GO:0010033;macromolecule catabolic process#GO:0009057;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;response to organonitrogen compound#GO:0010243;ERAD pathway#GO:0036503;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG169137|UniProtKB=T1F1G2 T1F1G2 20202662 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183584|UniProtKB=T1FJV7 T1FJV7 20209106 PTHR19303:SF71 TRANSPOSON ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG168923|UniProtKB=T1F150 T1F150 20202550 PTHR21522:SF32 PROTON CHANNEL OTOP OTOPETRIN-2 monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078;proton channel activity#GO:0015252;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;proton transmembrane transport#GO:1902600;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG150185|UniProtKB=T1EKE6 T1EKE6 20197046 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;heme binding#GO:0020037 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG64375|UniProtKB=T1FXT9 T1FXT9 20213637 PTHR12253:SF34 RH14732P PHOSPHOLIPASE A2 GROUP III, ISOFORM B HELRO|EnsemblGenome=HelroG175437|UniProtKB=T1F995 T1F995 20205394 PTHR33936:SF24 PROTEIN CBG17840 C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG74511|UniProtKB=T1G1S1 T1G1S1 20215019 PTHR10231:SF106 NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER UDP-GALACTOSE TRANSLOCATOR transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 cytoplasm#GO:0005737;bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG185299|UniProtKB=T1FMM7 T1FMM7 20210076 PTHR12646:SF0 NOT56 - RELATED DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE mannosyltransferase activity#GO:0000030;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG158693|UniProtKB=T1EN47 T1EN47 20197997 PTHR15176:SF1 NEPHROCYSTIN NEPHROCYSTIN-1 localization#GO:0051179;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;anatomical structure morphogenesis#GO:0009653;epithelium development#GO:0060429;anatomical structure development#GO:0048856;developmental process#GO:0032502;tissue morphogenesis#GO:0048729;morphogenesis of an epithelium#GO:0002009;cellular process#GO:0009987;tissue development#GO:0009888;protein localization#GO:0008104 cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cilium#GO:0005929;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular anatomical structure#GO:0005622 cell junction protein#PC00070 HELRO|EnsemblGenome=HelroG74895|UniProtKB=T1G1X4 T1G1X4 20215072 PTHR43272:SF83 LONG-CHAIN-FATTY-ACID--COA LIGASE ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J long-chain fatty acid-CoA ligase activity#GO:0004467;ligase activity#GO:0016874;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG170319|UniProtKB=T1F2X2 T1F2X2 20203171 PTHR10027:SF33 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic ion-gated channel activity#GO:0022839;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium-activated cation channel activity#GO:0005227;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG74950|UniProtKB=T1G1Y3 T1G1Y3 20215081 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-LIKE 1 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;localization#GO:0051179;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 membrane protein complex#GO:0098796;synapse#GO:0045202;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron projection#GO:0043005;transmembrane transporter complex#GO:1902495;cell projection#GO:0042995;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HELRO|EnsemblGenome=HelroG181423|UniProtKB=T1FGZ9 T1FGZ9 20208098 PTHR34914:SF1 LYMPHOCYTE EXPANSION MOLECULE LYMPHOCYTE EXPANSION MOLECULE HELRO|EnsemblGenome=HelroG159857|UniProtKB=T1EPH1 T1EPH1 20198471 PTHR11571:SF224 GLUTATHIONE S-TRANSFERASE HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE glutathione transferase activity#GO:0004364;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824 sulfur compound metabolic process#GO:0006790;nitrogen compound metabolic process#GO:0006807;peptide metabolic process#GO:0006518;cellular modified amino acid metabolic process#GO:0006575;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular process#GO:0009987;glutathione metabolic process#GO:0006749;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG176772|UniProtKB=T1FAW5 T1FAW5 20205964 PTHR45765:SF1 METHIONINE--TRNA LIGASE METHIONINE--TRNA LIGASE, CYTOPLASMIC catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG180379|UniProtKB=T1FFU9 T1FFU9 20207698 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG86578|UniProtKB=T1G6E3 T1G6E3 20216640 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG189610|UniProtKB=T1FR73 T1FR73 20211320 PTHR11106:SF111 GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED MACRO DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG73017|UniProtKB=T1G187 T1G187 20214835 PTHR48078:SF19 THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED ACT DOMAIN-CONTAINING PROTEIN lyase activity#GO:0016829;catalytic activity#GO:0003824 branched-chain amino acid metabolic process#GO:0009081;organonitrogen compound catabolic process#GO:1901565;biosynthetic process#GO:0009058;branched-chain amino acid biosynthetic process#GO:0009082;carboxylic acid biosynthetic process#GO:0046394;amino acid catabolic process#GO:0009063;nitrogen compound metabolic process#GO:0006807;alpha-amino acid metabolic process#GO:1901605;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;L-amino acid metabolic process#GO:0170033;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248;organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;alpha-amino acid biosynthetic process#GO:1901607;aspartate family amino acid metabolic process#GO:0009066;small molecule biosynthetic process#GO:0044283;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281 dehydratase#PC00091;lyase#PC00144 Isoleucine biosynthesis#P02748>Threonine dehydratase#P02995 HELRO|EnsemblGenome=HelroG180008|UniProtKB=T1FFC3 T1FFC3 20207522 PTHR19303:SF71 TRANSPOSON ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG172348|UniProtKB=T1F577 T1F577 20203976 PTHR24056:SF46 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 5 cyclin-dependent protein kinase activity#GO:0097472;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Nicotine pharmacodynamics pathway#P06587>CDK5#P06597;Axon guidance mediated by semaphorins#P00007>Cdk5#P00336;p53 pathway#P00059>Cdc2#P04634;Dopamine receptor mediated signaling pathway#P05912>CDK5#P05951 HELRO|EnsemblGenome=HelroG95510|UniProtKB=T1G963 T1G963 20217610 PTHR10625:SF5 HISTONE DEACETYLASE HDAC1-RELATED HISTONE DEACETYLASE histone modifying activity#GO:0140993;histone deacetylase activity#GO:0004407;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;deacetylase activity#GO:0019213;catalytic activity, acting on a protein#GO:0140096 protein-DNA complex organization#GO:0071824;cellular component organization#GO:0016043;cellular process#GO:0009987;epigenetic regulation of gene expression#GO:0040029;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;protein-containing complex organization#GO:0043933;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;histone deacetylase complex#GO:0000118;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG112029|UniProtKB=T1EFG6 T1EFG6 20195318 PTHR10747:SF38 TRANSCRIPTION FACTOR COE FAMILY MEMBER TRANSCRIPTION FACTOR COLLIER sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 P53-like transcription factor#PC00253;immunoglobulin fold transcription factor#PC00251 HELRO|EnsemblGenome=HelroG175852|UniProtKB=T1F9S1 T1F9S1 20205570 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159708|UniProtKB=T1EPC0 T1EPC0 20198420 PTHR11941:SF27 ENOYL-COA HYDRATASE-RELATED ETHYLMALONYL-COA DECARBOXYLASE lipid metabolic process#GO:0006629;oxoacid metabolic process#GO:0043436;cellular metabolic process#GO:0044237;lipid oxidation#GO:0034440;lipid modification#GO:0030258;lipid catabolic process#GO:0016042;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;fatty acid catabolic process#GO:0009062;primary metabolic process#GO:0044238;fatty acid metabolic process#GO:0006631;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;fatty acid beta-oxidation#GO:0006635;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;cellular lipid metabolic process#GO:0044255;carboxylic acid catabolic process#GO:0046395;cellular lipid catabolic process#GO:0044242;carboxylic acid metabolic process#GO:0019752;cellular catabolic process#GO:0044248;monocarboxylic acid catabolic process#GO:0072329;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 hydratase#PC00120 Succinate to proprionate conversion#P02777>Methylmalonyl-CoA decarboxylase#P03163 HELRO|EnsemblGenome=HelroG163207|UniProtKB=T1ETS9 T1ETS9 20199979 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG87741|UniProtKB=T1G6V1 T1G6V1 20216798 PTHR13948:SF3 RNA-BINDING PROTEIN FI21118P1 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG110137|UniProtKB=T1EEZ7 T1EEZ7 20195149 PTHR24416:SF564 TYROSINE-PROTEIN KINASE RECEPTOR MACROPHAGE-STIMULATING PROTEIN RECEPTOR signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;nervous system development#GO:0007399;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;system development#GO:0048731;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cell motility#GO:0048870;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;cell migration#GO:0016477;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG96355|UniProtKB=T1G9B6 T1G9B6 20217663 PTHR42884:SF13 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED NEUROENDOCRINE CONVERTASE 2 hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;regulation of hormone levels#GO:0010817;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;hormone metabolic process#GO:0042445;regulation of biological quality#GO:0065008;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;biological regulation#GO:0065007;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 bounding membrane of organelle#GO:0098588;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;extracellular region#GO:0005576;Golgi apparatus#GO:0005794;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;neuron projection#GO:0043005;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791;cell projection#GO:0042995;Golgi membrane#GO:0000139 serine protease#PC00203;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Furin#P00157;Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105 HELRO|EnsemblGenome=HelroG193850|UniProtKB=T1FVF0 T1FVF0 20212796 PTHR46205:SF3 LOQUACIOUS, ISOFORM B LOQUACIOUS, ISOFORM B HELRO|EnsemblGenome=HelroG171884|UniProtKB=T1F4T0 T1F4T0 20203829 PTHR21437:SF1 WIDE AWAKE WIDE AWAKE HELRO|EnsemblGenome=HelroG189297|UniProtKB=T1FQX6 T1FQX6 20211223 PTHR19282:SF516 TETRASPANIN TETRASPANIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185272|UniProtKB=T1FML3 T1FML3 20210062 PTHR11599:SF13 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT ALPHA TYPE-4 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;proteasome complex#GO:0000502;membrane-bounded organelle#GO:0043227;endopeptidase complex#GO:1905369;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protease#PC00190;protein modifying enzyme#PC00260 Parkinson disease#P00049>20S proteasome#P01227 HELRO|EnsemblGenome=HelroG62992|UniProtKB=T1FX91 T1FX91 20213439 PTHR43804:SF7 LD18447P LD18447P translation release factor#PC00225;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG83131|UniProtKB=T1G507 T1G507 20216155 PTHR12611:SF0 PUR-TRANSCRIPTIONAL ACTIVATOR PURINE-RICH BINDING PROTEIN-ALPHA, ISOFORM B sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG168910|UniProtKB=T1F144 T1F144 20202544 PTHR15818:SF2 G PATCH AND KOW-CONTAINING G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG75940|UniProtKB=T1G2D0 T1G2D0 20215228 PTHR23402:SF1 PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED PYROGLUTAMYL-PEPTIDASE I cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG192138|UniProtKB=T1FTM3 T1FTM3 20212170 PTHR21595:SF0 PATRONIN PATRONIN HELRO|EnsemblGenome=HelroG177213|UniProtKB=T1FBD1 T1FBD1 20206130 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG164391|UniProtKB=T1EVD3 T1EVD3 20200533 PTHR11927:SF9 GALACTOSIDE 2-L-FUCOSYLTRANSFERASE L-FUCOSYLTRANSFERASE transferase activity#GO:0016740;fucosyltransferase activity#GO:0008417;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein glycosylation#GO:0006486;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycosylation#GO:0070085;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG170497|UniProtKB=T1F347 T1F347 20203246 PTHR12195:SF0 CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED CYTOPLASMIC FMR1-INTERACTING PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;RNA cap binding#GO:0000339;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;developmental process#GO:0032502;cell morphogenesis#GO:0000902;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;anatomical structure morphogenesis#GO:0009653;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 Huntington disease#P00029>p53#P00797 HELRO|EnsemblGenome=HelroG165592|UniProtKB=T1EX18 T1EX18 20201118 PTHR46989:SF3 USP DOMAIN-CONTAINING PROTEIN USPA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG84252|UniProtKB=T1G5G5 T1G5G5 20216312 PTHR24073:SF128 DRAB5-RELATED RAB-LIKE PROTEIN 3 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 localization#GO:0051179;organic substance transport#GO:0071702;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;protein transport#GO:0015031;nitrogen compound transport#GO:0071705;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG177490|UniProtKB=T1FBS3 T1FBS3 20206272 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171258|UniProtKB=T1F400 T1F400 20203549 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193072|UniProtKB=T1FUL5 T1FUL5 20212511 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG95271|UniProtKB=T1G953 T1G953 20217600 PTHR43353:SF5 SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402;Aminobutyrate degradation#P02726>Succinate semi-aldehyde dehydrogenase#P02824;Gamma-aminobutyric acid synthesis#P04384>Succinic semialdehyde dehydrogenase#P04481 HELRO|EnsemblGenome=HelroG89886|UniProtKB=T1G7I8 T1G7I8 20217035 PTHR11178:SF1 IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL HELRO|EnsemblGenome=HelroG186277|UniProtKB=T1FNW6 T1FNW6 20210513 PTHR11570:SF0 S-ADENOSYLMETHIONINE DECARBOXYLASE S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME decarboxylase#PC00089;lyase#PC00144 HELRO|EnsemblGenome=HelroG185055|UniProtKB=T1FMC0 T1FMC0 20209969 PTHR31212:SF4 ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3 ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3 oxygenase#PC00177 HELRO|EnsemblGenome=HelroG76092|UniProtKB=T1G2E8 T1G2E8 20215246 PTHR11523:SF28 SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT NA_K-ATPASE BETA SUBUNIT ISOFORM 4-RELATED molecular function activator activity#GO:0140677;ATPase activator activity#GO:0001671;molecular function regulator activity#GO:0098772 inorganic ion homeostasis#GO:0098771;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;sodium ion homeostasis#GO:0055078;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;import into cell#GO:0098657;monoatomic cation transmembrane transport#GO:0098655;export from cell#GO:0140352;sodium ion transmembrane transport#GO:0035725;potassium ion import across plasma membrane#GO:1990573;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG107160|UniProtKB=T1EE81 T1EE81 20194883 PTHR23346:SF7 TRANSLATIONAL ACTIVATOR GCN1-RELATED STALLED RIBOSOME SENSOR GCN1 protein kinase regulator activity#GO:0019887;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 cellular response to stimulus#GO:0051716;regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;cell communication#GO:0007154;response to nutrient levels#GO:0031667;response to extracellular stimulus#GO:0009991;cellular process#GO:0009987;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;response to external stimulus#GO:0009605;regulation of cellular biosynthetic process#GO:0031326;response to stress#GO:0006950;cellular response to starvation#GO:0009267;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cellular response to nutrient levels#GO:0031669;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;response to starvation#GO:0042594;biological regulation#GO:0065007;cellular response to external stimulus#GO:0071496;regulation of translation#GO:0006417;regulation of macromolecule biosynthetic process#GO:0010556;cellular response to amino acid starvation#GO:0034198;regulation of gene expression#GO:0010468;cellular response to stress#GO:0033554;regulation of metabolic process#GO:0019222;cellular response to extracellular stimulus#GO:0031668;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG186534|UniProtKB=T1FP08 T1FP08 20210555 PTHR14146:SF0 EXOCYST COMPLEX COMPONENT 4 EXOCYST COMPLEX COMPONENT 4 localization#GO:0051179;localization within membrane#GO:0051668;cellular localization#GO:0051641;vesicle-mediated transport to the plasma membrane#GO:0098876;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;post-Golgi vesicle-mediated transport#GO:0006892;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;Golgi to plasma membrane transport#GO:0006893;export from cell#GO:0140352;secretion by cell#GO:0032940 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;vesicle tethering complex#GO:0099023;exocyst#GO:0000145;cell cortex#GO:0005938;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG161804|UniProtKB=T1ERX6 T1ERX6 20199326 PTHR12439:SF11 PLACENTAL PROTEIN 11-RELATED URIDYLATE-SPECIFIC ENDORIBONUCLEASE HELRO|EnsemblGenome=HelroG121581|UniProtKB=T1EGS4 T1EGS4 20195774 PTHR24247:SF222 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE (SEROTONIN) RECEPTOR 2B, ISOFORM E signaling receptor activity#GO:0038023;G protein-coupled amine receptor activity#GO:0008227;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;response to organic cyclic compound#GO:0014070;signal transduction#GO:0007165;cellular response to endogenous stimulus#GO:0071495;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;cellular response to organic substance#GO:0071310;trans-synaptic signaling#GO:0099537;response to organonitrogen compound#GO:0010243;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to nitrogen compound#GO:1901699;response to nitrogen compound#GO:1901698;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to oxygen-containing compound#GO:1901701;response to endogenous stimulus#GO:0009719;chemical synaptic transmission#GO:0007268;response to chemical#GO:0042221;anterograde trans-synaptic signaling#GO:0098916;cellular response to organonitrogen compound#GO:0071417;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;synaptic signaling#GO:0099536;cellular response to organic cyclic compound#GO:0071407;G protein-coupled receptor signaling pathway#GO:0007186;cell-cell signaling#GO:0007267;signaling#GO:0023052 somatodendritic compartment#GO:0036477;neuron projection#GO:0043005;dendrite#GO:0030425;cell periphery#GO:0071944;dendritic tree#GO:0097447;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG188890|UniProtKB=T1FQG1 T1FQG1 20211058 PTHR13866:SF29 SPARC OSTEONECTIN FOLLISTATIN cation binding#GO:0043169;extracellular matrix binding#GO:0050840;small molecule binding#GO:0036094;binding#GO:0005488;collagen binding#GO:0005518;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;protein-containing complex binding#GO:0044877;ion binding#GO:0043167 anatomical structure development#GO:0048856;developmental process#GO:0032502 extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 extracellular matrix glycoprotein#PC00100 HELRO|EnsemblGenome=HelroG193827|UniProtKB=T1FVE4 T1FVE4 20212790 PTHR15749:SF4 FANCONI-ASSOCIATED NUCLEASE 1 FANCONI-ASSOCIATED NUCLEASE 1 HELRO|EnsemblGenome=HelroG156805|UniProtKB=T1EM14 T1EM14 20197614 PTHR11557:SF0 PORPHOBILINOGEN DEAMINASE PORPHOBILINOGEN DEAMINASE transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824 tetrapyrrole metabolic process#GO:0033013;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;pigment metabolic process#GO:0042440;porphyrin-containing compound metabolic process#GO:0006778;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;heme biosynthetic process#GO:0006783;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;pigment biosynthetic process#GO:0046148;aromatic compound biosynthetic process#GO:0019438;organic substance metabolic process#GO:0071704;heme metabolic process#GO:0042168;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 deaminase#PC00088;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 Heme biosynthesis#P02746>Hydroxymethylbilane synthase#P02983 HELRO|EnsemblGenome=HelroG165469|UniProtKB=T1EWV0 T1EWV0 20201050 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164917|UniProtKB=T1EVZ1 T1EVZ1 20200741 PTHR12411:SF917 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN L cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197 macromolecule catabolic process#GO:0009057;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;proteolysis#GO:0006508;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;catabolic process#GO:0009056;organonitrogen compound catabolic process#GO:1901565;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;lysosome#GO:0005764;intracellular membrane-bounded organelle#GO:0043231;extracellular region#GO:0005576;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;organelle#GO:0043226;lytic vacuole#GO:0000323;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG77791|UniProtKB=T1G340 T1G340 20215488 PTHR14336:SF15 TANDEM PH DOMAIN CONTAINING PROTEIN DUAL ADAPTER FOR PHOSPHOTYROSINE AND 3-PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDE HELRO|EnsemblGenome=HelroG157163|UniProtKB=T1EM73 T1EM73 20197673 PTHR45809:SF3 VIRAL IAP-ASSOCIATED FACTOR HOMOLOG VIRAL IAP-ASSOCIATED FACTOR HOMOLOG macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG73542|UniProtKB=T1G1F6 T1G1F6 20214904 PTHR23245:SF31 TRNA METHYLTRANSFERASE TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3 HOMOLOG tRNA methyltransferase activity#GO:0008175;catalytic activity, acting on RNA#GO:0140098;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;RNA methyltransferase activity#GO:0008173 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;carbohydrate derivative metabolic process#GO:1901135;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;ncRNA metabolic process#GO:0034660;tRNA methylation#GO:0030488;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nucleic acid metabolic process#GO:0090304;methylation#GO:0032259;macromolecule methylation#GO:0043414;RNA methylation#GO:0001510;glycosyl compound metabolic process#GO:1901657 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG191283|UniProtKB=T1FSU3 T1FSU3 20211890 PTHR11346:SF189 GALECTIN GALECTIN carbohydrate binding#GO:0030246;binding#GO:0005488 extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG191379|UniProtKB=T1FSX9 T1FSX9 20211926 PTHR10145:SF6 TRANSCRIPTION ELONGATION FACTOR SPT6 TRANSCRIPTION ELONGATION FACTOR SPT6 nucleosome binding#GO:0031491;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;histone binding#GO:0042393;binding#GO:0005488;chromatin binding#GO:0003682 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;protein-DNA complex organization#GO:0071824;nucleosome organization#GO:0034728;RNA metabolic process#GO:0016070;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;transcription elongation by RNA polymerase II#GO:0006368;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;DNA-templated transcription elongation#GO:0006354;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;chromatin organization#GO:0006325;aromatic compound biosynthetic process#GO:0019438;chromatin remodeling#GO:0006338;transcription by RNA polymerase II#GO:0006366 membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;transcription elongation factor complex#GO:0008023;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG164968|UniProtKB=T1EW12 T1EW12 20200762 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG90376|UniProtKB=T1G7Q2 T1G7Q2 20217099 PTHR12636:SF5 NEP1/MRA1 RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1 catalytic activity, acting on RNA#GO:0140098;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;transferase activity#GO:0016740;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on a rRNA#GO:0140102;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;rRNA methyltransferase activity#GO:0008649;rRNA binding#GO:0019843;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;RNA methyltransferase activity#GO:0008173 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA modification#GO:0009451;rRNA modification#GO:0000154;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;ribosome biogenesis#GO:0042254;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;rRNA methylation#GO:0031167;nucleic acid metabolic process#GO:0090304;methylation#GO:0032259;macromolecule methylation#GO:0043414;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;rRNA base methylation#GO:0070475;RNA methylation#GO:0001510 transferase#PC00220;methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG70230|UniProtKB=T1G036 T1G036 20214434 PTHR45728:SF3 ACETYL-COA CARBOXYLASE, ISOFORM A ACETYL-COA CARBOXYLASE ligase activity#GO:0016874;catalytic activity#GO:0003824 organic acid biosynthetic process#GO:0016053;lipid metabolic process#GO:0006629;oxoacid metabolic process#GO:0043436;monocarboxylic acid biosynthetic process#GO:0072330;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;fatty acid metabolic process#GO:0006631;small molecule biosynthetic process#GO:0044283;cellular lipid metabolic process#GO:0044255;carboxylic acid metabolic process#GO:0019752;small molecule metabolic process#GO:0044281;fatty acid biosynthetic process#GO:0006633;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG180512|UniProtKB=T1FG01 T1FG01 20207750 PTHR47186:SF61 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 57 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 57-RELATED HELRO|EnsemblGenome=HelroG162022|UniProtKB=T1ES54 T1ES54 20199404 PTHR47160:SF10 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194295|UniProtKB=T1FVW6 T1FVW6 20212962 PTHR11384:SF67 ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1 carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;ATPase-coupled transmembrane transporter activity#GO:0042626;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;lipid transporter activity#GO:0005319;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;ATP binding#GO:0005524 lipid metabolic process#GO:0006629;monocarboxylic acid transport#GO:0015718;cellular localization#GO:0051641;macromolecule localization#GO:0033036;organic acid transport#GO:0015849;fatty acid transport#GO:0015908;transport#GO:0006810;lipid catabolic process#GO:0016042;lipid modification#GO:0030258;lipid transport#GO:0006869;carboxylic acid transmembrane transport#GO:1905039;organic substance transport#GO:0071702;establishment of localization#GO:0051234;fatty acid beta-oxidation#GO:0006635;catabolic process#GO:0009056;lipid localization#GO:0010876;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;cellular lipid catabolic process#GO:0044242;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;intracellular lipid transport#GO:0032365;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;transmembrane transport#GO:0055085;organic anion transport#GO:0015711;cellular metabolic process#GO:0044237;carboxylic acid transport#GO:0046942;lipid oxidation#GO:0034440;cellular component organization#GO:0016043;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;fatty acid catabolic process#GO:0009062;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic acid catabolic process#GO:0016054;fatty acid metabolic process#GO:0006631;small molecule catabolic process#GO:0044282;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;organic acid transmembrane transport#GO:1903825;intracellular transport#GO:0046907;cellular lipid metabolic process#GO:0044255;carboxylic acid metabolic process#GO:0019752;peroxisome organization#GO:0007031;long-chain fatty acid transport#GO:0015909;monocarboxylic acid catabolic process#GO:0072329;small molecule metabolic process#GO:0044281 bounding membrane of organelle#GO:0098588;peroxisomal membrane#GO:0005778;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;peroxisome#GO:0005777;microbody#GO:0042579;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG189138|UniProtKB=T1FQQ0 T1FQQ0 20211147 PTHR24241:SF76 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR NEUROPEPTIDE SIFAMIDE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;binding#GO:0005488;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888;amide binding#GO:0033218 response to organic substance#GO:0010033;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;response to hormone#GO:0009725;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG142748|UniProtKB=T1EJ73 T1EJ73 20196623 PTHR19303:SF71 TRANSPOSON ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG185618|UniProtKB=T1FN18 T1FN18 20210217 PTHR24256:SF572 TRYPTASE-RELATED PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG107575|UniProtKB=T1EEB4 T1EEB4 20194916 PTHR19855:SF11 WD40 REPEAT PROTEIN 12, 37 RIBOSOME BIOGENESIS PROTEIN WDR12 HELRO|EnsemblGenome=HelroG175370|UniProtKB=T1F972 T1F972 20205371 PTHR20961:SF38 GLYCOSYLTRANSFERASE PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2 transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG70726|UniProtKB=T1G0B2 T1G0B2 20214510 PTHR13329:SF2 MITOCHONDRIAL RIBOSOMAL PROTEIN S18B SMALL RIBOSOMAL SUBUNIT PROTEIN MS40 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG186172|UniProtKB=T1FNR7 T1FNR7 20210464 PTHR10218:SF227 GTP-BINDING PROTEIN ALPHA SUBUNIT G PROTEIN ALPHA I SUBUNIT GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;ribonucleoside triphosphate phosphatase activity#GO:0017111;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 regulation of biological process#GO:0050789;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;side of membrane#GO:0098552;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;extrinsic component of membrane#GO:0019898 heterotrimeric G-protein#PC00117;G-protein#PC00020 Enkephalin release#P05913>G-Protein (i)#P05974;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Gialpha#P00712;Opioid proenkephalin pathway#P05915>G-protein#P05994;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;Opioid prodynorphin pathway#P05916>G-protein#P06002;PI3 kinase pathway#P00048>Galpha#P01199;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047 HELRO|EnsemblGenome=HelroG192521|UniProtKB=T1FU18 T1FU18 20212314 PTHR14191:SF3 PDZ DOMAIN CONTAINING PROTEIN NA(+)_H(+) EXCHANGE REGULATORY COFACTOR-LIKE PROTEIN NRFL-1 protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 localization#GO:0051179;protein localization to plasma membrane#GO:0072659;protein localization to cell periphery#GO:1990778;localization within membrane#GO:0051668;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;cellular process#GO:0009987;protein localization#GO:0008104 plasma membrane region#GO:0098590;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;apical part of cell#GO:0045177;plasma membrane#GO:0005886;apical plasma membrane#GO:0016324 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG73394|UniProtKB=T1G1D5 T1G1D5 20214883 PTHR10632:SF2 SULFIDE:QUINONE OXIDOREDUCTASE SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL nucleotide binding#GO:0000166;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;flavin adenine dinucleotide binding#GO:0050660;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;oxidoreductase activity#GO:0016491 cellular metabolic process#GO:0044237;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;metabolic process#GO:0008152 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG162879|UniProtKB=T1ETB1 T1ETB1 20199811 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG62144|UniProtKB=T1FWW2 T1FWW2 20213310 PTHR20903:SF0 PREFOLDIN SUBUNIT 1-RELATED PREFOLDIN SUBUNIT 1 protein binding#GO:0005515;unfolded protein binding#GO:0051082;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG71941|UniProtKB=T1G0T1 T1G0T1 20214679 PTHR15460:SF3 PEROXISOMAL MEMBRANE PROTEIN 4 PEROXISOMAL MEMBRANE PROTEIN 4 peroxisomal membrane#GO:0005778;cytoplasm#GO:0005737;bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;peroxisome#GO:0005777;microbody#GO:0042579;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG179020|UniProtKB=T1FE25 T1FE25 20207074 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG138705|UniProtKB=T1EIW7 T1EIW7 20196517 PTHR19290:SF164 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED BHLH DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;neurogenesis#GO:0022008;positive regulation of RNA biosynthetic process#GO:1902680;cell projection organization#GO:0030030;regulation of nitrogen compound metabolic process#GO:0051171;animal organ development#GO:0048513;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;regulation of biological process#GO:0050789;system development#GO:0048731;cell differentiation#GO:0030154;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;neuron differentiation#GO:0030182;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;multicellular organism development#GO:0007275;cellular component organization#GO:0016043;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;anatomical structure development#GO:0048856;biological regulation#GO:0065007;neuron development#GO:0048666;multicellular organismal process#GO:0032501;positive regulation of RNA metabolic process#GO:0051254;generation of neurons#GO:0048699;sensory organ development#GO:0007423;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG174236|UniProtKB=T1F7U7 T1F7U7 20204896 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG97122|UniProtKB=T1G9F6 T1G9F6 20217703 PTHR24637:SF428 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG90841|UniProtKB=T1G7W8 T1G7W8 20217165 PTHR45771:SF6 HOMEOTIC PROTEIN DEFORMED HOMEOTIC PROTEIN SEX COMBS REDUCED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;pattern specification process#GO:0007389;positive regulation of biological process#GO:0048518;regulation of DNA-templated transcription#GO:0006355;multicellular organism development#GO:0007275;regionalization#GO:0003002;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;anatomical structure development#GO:0048856;biological regulation#GO:0065007;anterior/posterior pattern specification#GO:0009952;multicellular organismal process#GO:0032501;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG190174|UniProtKB=T1FRR5 T1FRR5 20211512 PTHR45902:SF4 LATROPHILIN RECEPTOR-LIKE PROTEIN A G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG122556|UniProtKB=T1EGV1 T1EGV1 20195801 PTHR19300:SF57 BETA-1,4-GALACTOSYLTRANSFERASE BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE galactosyltransferase activity#GO:0008378;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycosylation#GO:0070085;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG164871|UniProtKB=T1EVW7 T1EVW7 20200717 PTHR15549:SF26 PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR AXIAL BUDDING PATTERN PROTEIN 2-RELATED immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG194688|UniProtKB=T1FWB6 T1FWB6 20213112 PTHR22957:SF212 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN RELATED TO THE N TERMINUS OF TRE ONCOGENE, ISOFORM A nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;activation of GTPase activity#GO:0090630;biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG72683|UniProtKB=T1G139 T1G139 20214787 PTHR11249:SF2 GLIAL FACTOR NATURATION FACTOR GLIA MATURATION FACTOR protein-containing complex binding#GO:0044877;binding#GO:0005488 negative regulation of biological process#GO:0048519;regulation of organelle organization#GO:0033043;regulation of actin filament organization#GO:0110053;regulation of cellular component organization#GO:0051128;cellular process#GO:0009987;negative regulation of supramolecular fiber organization#GO:1902904;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of cytoskeleton organization#GO:0051493;actin filament-based process#GO:0030029;regulation of cellular process#GO:0050794;negative regulation of organelle organization#GO:0010639;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament-based process#GO:0032970;negative regulation of cellular component organization#GO:0051129;negative regulation of cellular process#GO:0048523;negative regulation of cytoskeleton organization#GO:0051494 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;cell cortex#GO:0005938;cell periphery#GO:0071944;cortical actin cytoskeleton#GO:0030864;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG158445|UniProtKB=T1EMS8 T1EMS8 20197878 PTHR43785:SF14 GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE GLUTAMINE SYNTHETASE metabolite interconversion enzyme#PC00262;ligase#PC00142 HELRO|EnsemblGenome=HelroG193298|UniProtKB=T1FUU8 T1FUU8 20212594 PTHR16021:SF20 MANSC DOMAIN CONTAINING PROTEIN 1 C3H1-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG84352|UniProtKB=T1G5H7 T1G5H7 20216324 PTHR10302:SF0 SINGLE-STRANDED DNA-BINDING PROTEIN SINGLE-STRANDED DNA-BINDING PROTEIN, MITOCHONDRIAL nucleic acid binding#GO:0003676;single-stranded DNA binding#GO:0003697;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;positive regulation of catalytic activity#GO:0043085;regulation of molecular function#GO:0065009 cellular anatomical entity#GO:0110165 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG179460|UniProtKB=T1FER1 T1FER1 20207310 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG122103|UniProtKB=T1EGT9 T1EGT9 20195789 PTHR47023:SF1 SEX PEPTIDE RECEPTOR SEX PEPTIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG182716|UniProtKB=T1FIM9 T1FIM9 20208678 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED BRCT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178236|UniProtKB=T1FCZ4 T1FCZ4 20206693 PTHR33273:SF4 DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG67222|UniProtKB=T1FYY3 T1FYY3 20214031 PTHR13490:SF0 MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28 SMALL RIBOSOMAL SUBUNIT PROTEIN MS35 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;organellar ribosome#GO:0000313;protein-containing complex#GO:0032991;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;small ribosomal subunit#GO:0015935;ribosome#GO:0005840;mitochondrial small ribosomal subunit#GO:0005763;mitochondrial protein-containing complex#GO:0098798 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG95925|UniProtKB=T1G989 T1G989 20217636 PTHR24223:SF443 ATP-BINDING CASSETTE SUB-FAMILY C MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG102849|UniProtKB=T1EDC4 T1EDC4 20194576 PTHR12611:SF0 PUR-TRANSCRIPTIONAL ACTIVATOR PURINE-RICH BINDING PROTEIN-ALPHA, ISOFORM B sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG146448|UniProtKB=T1EJS3 T1EJS3 20196823 PTHR15561:SF0 CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;transcription by RNA polymerase III#GO:0006383;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;aromatic compound biosynthetic process#GO:0019438;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;RNA polymerase III complex#GO:0005666;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG176375|UniProtKB=T1FAG4 T1FAG4 20205813 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG169944|UniProtKB=T1F2G6 T1F2G6 20203016 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED FMRFAMIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG129617|UniProtKB=T1EHR7 T1EHR7 20196117 PTHR24238:SF75 G-PROTEIN COUPLED RECEPTOR CHOLECYSTOKININ-LIKE RECEPTOR AT 17D1-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;neuropeptide signaling pathway#GO:0007218;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG116789|UniProtKB=T1EGH8 T1EGH8 20195680 PTHR10264:SF127 BAND 7 PROTEIN-RELATED PODOCIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG111962|UniProtKB=T1EFG0 T1EFG0 20195312 PTHR11360:SF260 MONOCARBOXYLATE TRANSPORTER MFS DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;monocarboxylic acid transmembrane transporter activity#GO:0008028;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;monocarboxylic acid transport#GO:0015718;establishment of localization#GO:0051234;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942 transporter#PC00227 HELRO|EnsemblGenome=HelroG194830|UniProtKB=T1FWG6 T1FWG6 20213161 PTHR23504:SF1 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10 GH21943P-RELATED secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG105060|UniProtKB=T1EDQ2 T1EDQ2 20194704 PTHR13186:SF0 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;core mediator complex#GO:0070847;RNA polymerase II transcription regulator complex#GO:0090575;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG193045|UniProtKB=T1FUK1 T1FUK1 20212497 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG180511|UniProtKB=T1FG00 T1FG00 20207749 PTHR19211:SF14 ATP-BINDING TRANSPORT PROTEIN-RELATED ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1 nucleotide binding#GO:0000166;carbohydrate derivative binding#GO:0097367;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168;ATP binding#GO:0005524 translation elongation factor#PC00222;translational protein#PC00263 HELRO|EnsemblGenome=HelroG180009|UniProtKB=T1FFC4 T1FFC4 20207523 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG65555|UniProtKB=T1FY95 T1FY95 20213793 PTHR16105:SF0 RNA-BINDING REGION-CONTAINING PROTEIN 3 RNA-BINDING REGION-CONTAINING PROTEIN 3 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;snRNA binding#GO:0017069;pre-mRNA binding#GO:0036002;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;U12-type spliceosomal complex#GO:0005689 HELRO|EnsemblGenome=HelroG66461|UniProtKB=T1FYL4 T1FYL4 20213912 PTHR48012:SF10 STERILE20-LIKE KINASE, ISOFORM B-RELATED FI20177P1 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG171157|UniProtKB=T1F3V9 T1F3V9 20203508 PTHR15561:SF0 CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;transcription by RNA polymerase III#GO:0006383;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;aromatic compound biosynthetic process#GO:0019438;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;RNA polymerase III complex#GO:0005666;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG189940|UniProtKB=T1FRI4 T1FRI4 20211431 PTHR11640:SF31 NEPHRIN IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;binding#GO:0005488 cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987 cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;cell-cell junction#GO:0005911;anchoring junction#GO:0070161;plasma membrane#GO:0005886 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG168519|UniProtKB=T1F0N5 T1F0N5 20202385 PTHR11652:SF71 30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER SMALL RIBOSOMAL SUBUNIT PROTEIN US12M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG162325|UniProtKB=T1ESI2 T1ESI2 20199532 PTHR10258:SF8 CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA CALCIUM-ACTIVATED POTASSIUM CHANNEL BK ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;molecular function regulator activity#GO:0098772;transporter regulator activity#GO:0141108;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic ion-gated channel activity#GO:0022839;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium-activated cation channel activity#GO:0005227;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;potassium channel regulator activity#GO:0015459;ligand-gated monoatomic cation channel activity#GO:0099094;channel regulator activity#GO:0016247;monoatomic ion channel activity#GO:0005216;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 detection of stimulus#GO:0051606;response to stimulus#GO:0050896;response to chemical#GO:0042221;detection of chemical stimulus#GO:0009593 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG81183|UniProtKB=T1G4A8 T1G4A8 20215906 PTHR11255:SF54 DIACYLGLYCEROL KINASE DIACYLGLYCEROL KINASE THETA transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301;lipid kinase activity#GO:0001727 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transferase#PC00220;kinase#PC00137;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG144436|UniProtKB=T1EJE6 T1EJE6 20196696 PTHR24390:SF235 ZINC FINGER PROTEIN GH09339P-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG188195|UniProtKB=T1FPR6 T1FPR6 20210813 PTHR45686:SF4 ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H vesicle targeting, to, from or within Golgi#GO:0048199;cellular localization#GO:0051641;organelle localization#GO:0051640;vesicle localization#GO:0051648;membrane organization#GO:0061024;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;vesicle targeting#GO:0006903;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;vesicle budding from membrane#GO:0006900;establishment of vesicle localization#GO:0051650;organelle organization#GO:0006996;vesicle organization#GO:0016050;establishment of localization in cell#GO:0051649;establishment of organelle localization#GO:0051656 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG154433|UniProtKB=T1ELE8 T1ELE8 20197398 PTHR21250:SF0 PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG182831|UniProtKB=T1FIT8 T1FIT8 20208737 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173822|UniProtKB=T1F7A1 T1F7A1 20204700 PTHR33395:SF21 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED PERICARDIN heart morphogenesis#GO:0003007;system development#GO:0048731;heart development#GO:0007507;circulatory system development#GO:0072359;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;animal organ development#GO:0048513;multicellular organism development#GO:0007275;developmental process#GO:0032502;animal organ morphogenesis#GO:0009887;multicellular organismal process#GO:0032501;cell adhesion#GO:0007155;cellular process#GO:0009987;post-embryonic development#GO:0009791 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG191958|UniProtKB=T1FTG2 T1FTG2 20212109 PTHR46165:SF7 SET AND MYND DOMAIN-CONTAINING PROTEIN 4 SET AND MYND DOMAIN-CONTAINING PROTEIN 4 enzyme binding#GO:0019899;protein binding#GO:0005515;histone deacetylase binding#GO:0042826;binding#GO:0005488 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG188342|UniProtKB=T1FPW6 T1FPW6 20210863 PTHR10334:SF590 CYSTEINE-RICH SECRETORY PROTEIN-RELATED SCP DOMAIN-CONTAINING PROTEIN extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG128981|UniProtKB=T1EHR0 T1EHR0 20196110 PTHR11255:SF109 DIACYLGLYCEROL KINASE DIACYLGLYCEROL KINASE ETA transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301;lipid kinase activity#GO:0001727 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transferase#PC00220;kinase#PC00137;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG77374|UniProtKB=T1G2X0 T1G2X0 20215418 PTHR18916:SF82 DYNACTIN 1-RELATED MICROTUBULE-BINDING CAP-GLY DOMAIN-CONTAINING PROTEIN cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;microtubule plus-end binding#GO:0051010;binding#GO:0005488 cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987;cytoplasmic microtubule organization#GO:0031122 supramolecular complex#GO:0099080;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;supramolecular polymer#GO:0099081;cellular anatomical entity#GO:0110165;cell cortex#GO:0005938;cell periphery#GO:0071944;supramolecular fiber#GO:0099512;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;microtubule plus-end#GO:0035371;microtubule#GO:0005874 chaperone#PC00072 HELRO|EnsemblGenome=HelroG165651|UniProtKB=T1EX46 T1EX46 20201146 PTHR19303:SF73 TRANSPOSON PROTEIN PDC2 nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG189456|UniProtKB=T1FR28 T1FR28 20211275 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG183444|UniProtKB=T1FJN9 T1FJN9 20209038 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED single-stranded RNA binding#GO:0003727;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;poly(A) binding#GO:0008143;binding#GO:0005488;organic cyclic compound binding#GO:0097159 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG194017|UniProtKB=T1FVK6 T1FVK6 20212852 PTHR13723:SF305 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE PROTEIN MADD-4 hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;cellular component organization#GO:0016043;cellular process#GO:0009987;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG176454|UniProtKB=T1FAI8 T1FAI8 20205837 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG192663|UniProtKB=T1FU61 T1FU61 20212357 PTHR43344:SF2 PHOSPHOSERINE PHOSPHATASE PHOSPHOSERINE PHOSPHATASE cation binding#GO:0043169;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;magnesium ion binding#GO:0000287;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;metal ion binding#GO:0046872;ion binding#GO:0043167;phosphoric ester hydrolase activity#GO:0042578 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;proteinogenic amino acid biosynthetic process#GO:0170038;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;phosphorus metabolic process#GO:0006793;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;alpha-amino acid biosynthetic process#GO:1901607;nitrogen compound metabolic process#GO:0006807;dephosphorylation#GO:0016311;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;small molecule biosynthetic process#GO:0044283;L-amino acid biosynthetic process#GO:0170034;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 phosphatase#PC00181;hydrolase#PC00121 Serine glycine biosynthesis#P02776>Phosphoserine phosphatase#P03159 HELRO|EnsemblGenome=HelroG109971|UniProtKB=T1EEX9 T1EEX9 20195131 PTHR48099:SF11 C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE_CYCLOHYDROLASE, MITOCHONDRIAL hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular modified amino acid metabolic process#GO:0006575;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;folic acid-containing compound metabolic process#GO:0006760;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262 Formyltetrahydrofolate biosynthesis#P02743>Methylene tetrahydrofolate dehydrogenase#P02952 HELRO|EnsemblGenome=HelroG72182|UniProtKB=T1G0W9 T1G0W9 20214717 PTHR12277:SF81 ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN PROTEIN ABHD13 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG154098|UniProtKB=T1ELD7 T1ELD7 20197387 PTHR13412:SF0 T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG T-CELL IMMUNOMODULATORY PROTEIN HELRO|EnsemblGenome=HelroG176353|UniProtKB=T1FAF4 T1FAF4 20205803 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG166724|UniProtKB=T1EYF7 T1EYF7 20201607 PTHR22504:SF0 REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG enzyme binding#GO:0019899;protein binding#GO:0005515;RNA polymerase binding#GO:0070063;binding#GO:0005488;RNA polymerase core enzyme binding#GO:0043175 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG165154|UniProtKB=T1EWC4 T1EWC4 20200874 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182447|UniProtKB=T1FI75 T1FI75 20208524 PTHR21461:SF69 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 glycosylation#GO:0070085;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG191389|UniProtKB=T1FSY3 T1FSY3 20211930 PTHR15427:SF52 EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER C1Q DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG139567|UniProtKB=T1EIZ1 T1EIZ1 20196541 PTHR24248:SF125 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR DOPAMINE D2-LIKE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG86803|UniProtKB=T1G6H0 T1G6H0 20216667 PTHR24049:SF32 CRUMBS FAMILY MEMBER EGF-LIKE DOMAIN-CONTAINING PROTEIN cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG96079|UniProtKB=T1G9A2 T1G9A2 20217649 PTHR12411:SF917 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN L cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197 macromolecule catabolic process#GO:0009057;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;proteolysis#GO:0006508;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;catabolic process#GO:0009056;organonitrogen compound catabolic process#GO:1901565;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;lysosome#GO:0005764;intracellular membrane-bounded organelle#GO:0043231;extracellular region#GO:0005576;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;organelle#GO:0043226;lytic vacuole#GO:0000323;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG79937|UniProtKB=T1G3V3 T1G3V3 20215751 PTHR23092:SF15 POLY(A) RNA POLYMERASE INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED adenylyltransferase activity#GO:0070566;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;transferase activity#GO:0016740;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772;mRNA binding#GO:0003729 cellular aromatic compound metabolic process#GO:0006725;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;modification-dependent macromolecule catabolic process#GO:0043632;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;organic substance catabolic process#GO:1901575;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;macromolecule biosynthetic process#GO:0009059;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;polyadenylation-dependent ncRNA catabolic process#GO:0043634 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG110061|UniProtKB=T1EEY9 T1EEY9 20195141 PTHR45819:SF5 CENTAURIN-GAMMA-1A CENTAURIN-GAMMA-1A GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;catalytic activity#GO:0003824;molecular function regulator activity#GO:0098772;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;enzyme activator activity#GO:0008047;ribonucleoside triphosphate phosphatase activity#GO:0017111;enzyme regulator activity#GO:0030234 regulation of GTPase activity#GO:0043087;regulation of molecular function#GO:0065009;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;activation of GTPase activity#GO:0090630;biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG105257|UniProtKB=T1EDS5 T1EDS5 20194727 PTHR31733:SF1 RIBONUCLEASE KAPPA RIBONUCLEASE KAPPA catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG80241|UniProtKB=T1G3Z0 T1G3Z0 20215788 PTHR24637:SF420 COLLAGEN NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186271|UniProtKB=T1FNW2 T1FNW2 20210509 PTHR43721:SF36 ELONGATION FACTOR TU-RELATED ELONGATION FACTOR TU, MITOCHONDRIAL nucleic acid binding#GO:0003676;translation regulator activity#GO:0045182;translation regulator activity, nucleic acid binding#GO:0090079;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation elongation factor activity#GO:0003746;translation factor activity, RNA binding#GO:0008135 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;mitochondrial gene expression#GO:0140053;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;mitochondrial translation#GO:0032543;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;translational elongation#GO:0006414;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 translation elongation factor#PC00222;translational protein#PC00263 HELRO|EnsemblGenome=HelroG63207|UniProtKB=T1FXC3 T1FXC3 20213471 PTHR24390:SF222 ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG181869|UniProtKB=T1FHE9 T1FHE9 20208248 PTHR11588:SF504 TUBULIN TUBULIN BETA-1 CHAIN-RELATED carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;structural molecule activity#GO:0005198;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;structural constituent of cytoskeleton#GO:0005200 cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;microtubule-based process#GO:0007017;organelle organization#GO:0006996;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;cell cycle#GO:0007049;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 tubulin#PC00228;microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Microtubule#P00780;Huntington disease#P00029>beta-Tubulin#P00790;Cytoskeletal regulation by Rho GTPase#P00016>tubulin#P00526 HELRO|EnsemblGenome=HelroG181270|UniProtKB=T1FGT7 T1FGT7 20208036 PTHR24085:SF4 NUCLEAR HORMONE RECEPTOR NUCLEAR HORMONE RECEPTOR HR38-RELATED cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;double-stranded DNA binding#GO:0003690;transcription factor binding#GO:0008134;DNA-binding transcription factor binding#GO:0140297;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nuclear receptor binding#GO:0016922;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;protein binding#GO:0005515;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of nitrogen compound metabolic process#GO:0051171;response to peptide hormone#GO:0043434;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;cellular response to nitrogen compound#GO:1901699;regulation of biological process#GO:0050789;cellular response to oxygen-containing compound#GO:1901701;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;response to peptide#GO:1901652;regulation of biosynthetic process#GO:0009889;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;cellular response to endogenous stimulus#GO:0071495;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;cellular response to organic substance#GO:0071310;regulation of DNA-templated transcription#GO:0006355;response to organonitrogen compound#GO:0010243;cellular response to peptide#GO:1901653;cellular response to peptide hormone stimulus#GO:0071375;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to hormone#GO:0009725;regulation of cellular biosynthetic process#GO:0031326;response to chemical#GO:0042221;regulation of macromolecule metabolic process#GO:0060255;cellular response to organonitrogen compound#GO:0071417;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG162919|UniProtKB=T1ETC9 T1ETC9 20199829 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185077|UniProtKB=T1FMD3 T1FMD3 20209982 PTHR47979:SF24 DRAB11-RELATED SMALL MONOMERIC GTPASE GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;anion binding#GO:0043168;ion binding#GO:0043167 localization#GO:0051179;regulation of biological process#GO:0050789;regulation of endocytosis#GO:0030100;regulation of transport#GO:0051049;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;transport#GO:0006810;biological regulation#GO:0065007;regulation of localization#GO:0032879;vesicle-mediated transport#GO:0016192;regulation of cellular component organization#GO:0051128;cellular process#GO:0009987;regulation of vesicle-mediated transport#GO:0060627 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG106899|UniProtKB=T1EE58 T1EE58 20194860 PTHR48081:SF33 AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C KYNURENINE FORMAMIDASE metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG162788|UniProtKB=T1ET55 T1ET55 20199755 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176164|UniProtKB=T1FA86 T1FA86 20205735 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193202|UniProtKB=T1FUR0 T1FUR0 20212556 PTHR23107:SF34 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN HTH LA-TYPE RNA-BINDING DOMAIN-CONTAINING PROTEIN transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG161135|UniProtKB=T1ER48 T1ER48 20199048 PTHR22255:SF9 LP06548P LP06548P HELRO|EnsemblGenome=HelroG71825|UniProtKB=T1G0S0 T1G0S0 20214668 PTHR10416:SF0 DNA POLYMERASE DELTA SUBUNIT 2 DNA POLYMERASE DELTA SUBUNIT 2 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;DNA-templated DNA replication#GO:0006261;DNA replication#GO:0006260;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA strand elongation involved in DNA replication#GO:0006271 DNA polymerase complex#GO:0042575;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695 DNA-directed DNA polymerase#PC00018;DNA metabolism protein#PC00009 DNA replication#P00017>Pol delta#P00533 HELRO|EnsemblGenome=HelroG175644|UniProtKB=T1F9G7 T1F9G7 20205466 PTHR24241:SF76 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR NEUROPEPTIDE SIFAMIDE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;binding#GO:0005488;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888;amide binding#GO:0033218 response to organic substance#GO:0010033;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;response to hormone#GO:0009725;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG195124|UniProtKB=T1FWS1 T1FWS1 20213266 PTHR14211:SF7 GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2 RIBOSOME BIOGENESIS PROTEIN NOP53 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;rRNA binding#GO:0019843;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;ribosomal large subunit biogenesis#GO:0042273;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;ribosomal large subunit assembly#GO:0000027;ribosome biogenesis#GO:0042254;non-membrane-bounded organelle assembly#GO:0140694;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;protein-RNA complex organization#GO:0071826 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG190726|UniProtKB=T1FS88 T1FS88 20211685 PTHR11101:SF80 PHOSPHATE TRANSPORTER PHOSPHATE TRANSPORTER inorganic molecular entity transmembrane transporter activity#GO:0015318;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;inorganic anion transmembrane transport#GO:0098661;phosphate ion transport#GO:0006817;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;inorganic anion transport#GO:0015698 transporter#PC00227 HELRO|EnsemblGenome=HelroG65616|UniProtKB=T1FYA6 T1FYA6 20213804 PTHR12300:SF117 HVA22-LIKE PROTEINS LP05237P-RELATED membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG194472|UniProtKB=T1FW34 T1FW34 20213030 PTHR14166:SF17 SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN RHO-GAP DOMAIN-CONTAINING PROTEIN GTPase-activating protein#PC00257 PDGF signaling pathway#P00047>Rho#P01174 HELRO|EnsemblGenome=HelroG76743|UniProtKB=T1G2N7 T1G2N7 20215335 PTHR18966:SF422 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED signaling receptor activity#GO:0038023;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;ligand-gated channel activity#GO:0022834 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019 HELRO|EnsemblGenome=HelroG72129|UniProtKB=T1G0W2 T1G0W2 20214710 PTHR10390:SF61 HOMEOBOX PROTEIN SIX HOMEOBOX PROTEIN SIX2 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG63882|UniProtKB=T1FXL9 T1FXL9 20213567 PTHR23405:SF4 MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED PROTEIN MAK16 HOMOLOG cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of 5.8S rRNA#GO:0000460;maturation of LSU-rRNA#GO:0000470;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;preribosome, large subunit precursor#GO:0030687;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981 HELRO|EnsemblGenome=HelroG71906|UniProtKB=T1G0S8 T1G0S8 20214676 PTHR10943:SF2 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 peptidase complex#GO:1905368;proteasome accessory complex#GO:0022624;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;proteasome regulatory particle#GO:0005838;catalytic complex#GO:1902494;proteasome complex#GO:0000502;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;endopeptidase complex#GO:1905369;membrane-bounded organelle#GO:0043227 protease#PC00190;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG158580|UniProtKB=T1EMZ0 T1EMZ0 20197940 PTHR45749:SF21 FAMILY NOT NAMED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG90075|UniProtKB=T1G7K8 T1G7K8 20217055 PTHR11920:SF501 GUANYLYL CYCLASE GUANYLATE CYCLASE 32E adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG194498|UniProtKB=T1FW45 T1FW45 20213041 PTHR24184:SF11 SI:CH211-189E2.2 ANKYRIN REPEAT AND SOCS BOX CONTAINING 3 HELRO|EnsemblGenome=HelroG162972|UniProtKB=T1ETG7 T1ETG7 20199867 PTHR36191:SF10 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG108533|UniProtKB=T1EEJ9 T1EEJ9 20195001 PTHR42721:SF42 SUGAR HYDROLASE-RELATED FIBRONECTIN TYPE III-LIKE DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 polysaccharide metabolic process#GO:0005976;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;carbohydrate catabolic process#GO:0016052;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;cellular process#GO:0009987;carbohydrate metabolic process#GO:0005975;cell wall organization or biogenesis#GO:0071554;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 glucosidase#PC00108;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG176749|UniProtKB=T1FAV5 T1FAV5 20205954 PTHR19960:SF11 TEKTIN TEKTIN cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cilium or flagellum-dependent cell motility#GO:0001539;cell motility#GO:0048870;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;cilium movement involved in cell motility#GO:0060294;cilium movement#GO:0003341;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cilium-dependent cell motility#GO:0060285;microtubule-based process#GO:0007017;organelle organization#GO:0006996;plasma membrane bounded cell projection assembly#GO:0120031 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG182988|UniProtKB=T1FJ21 T1FJ21 20208820 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG127849|UniProtKB=T1EHI7 T1EHI7 20196037 PTHR10252:SF79 HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED DNA POLYMERASE EPSILON SUBUNIT 4 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;DNA-templated DNA replication#GO:0006261;DNA replication#GO:0006260;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;transferase complex#GO:1990234;epsilon DNA polymerase complex#GO:0008622;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;intracellular protein-containing complex#GO:0140535;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;DNA polymerase complex#GO:0042575;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG158944|UniProtKB=T1ENF4 T1ENF4 20198104 PTHR13245:SF14 RRP15-LIKE PROTEIN RRP15-LIKE PROTEIN cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of 5.8S rRNA#GO:0000460;maturation of LSU-rRNA#GO:0000470;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;preribosome, large subunit precursor#GO:0030687;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG79551|UniProtKB=T1G3Q0 T1G3Q0 20215698 PTHR11941:SF54 ENOYL-COA HYDRATASE-RELATED ENOYL-COA HYDRATASE, MITOCHONDRIAL lipid metabolic process#GO:0006629;oxoacid metabolic process#GO:0043436;cellular metabolic process#GO:0044237;lipid oxidation#GO:0034440;lipid modification#GO:0030258;lipid catabolic process#GO:0016042;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;fatty acid catabolic process#GO:0009062;primary metabolic process#GO:0044238;fatty acid metabolic process#GO:0006631;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;fatty acid beta-oxidation#GO:0006635;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;cellular lipid metabolic process#GO:0044255;carboxylic acid catabolic process#GO:0046395;cellular lipid catabolic process#GO:0044242;carboxylic acid metabolic process#GO:0019752;cellular catabolic process#GO:0044248;monocarboxylic acid catabolic process#GO:0072329;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 hydratase#PC00120 Succinate to proprionate conversion#P02777>Methylmalonyl-CoA decarboxylase#P03163 HELRO|EnsemblGenome=HelroG184872|UniProtKB=T1FM39 T1FM39 20209888 PTHR10766:SF41 TRANSMEMBRANE 9 SUPERFAMILY PROTEIN TRANSMEMBRANE 9 SUPERFAMILY MEMBER 3 localization#GO:0051179;localization within membrane#GO:0051668;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;cellular process#GO:0009987;protein localization#GO:0008104 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG177299|UniProtKB=T1FBH1 T1FBH1 20206170 PTHR23011:SF41 CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159715|UniProtKB=T1EPC2 T1EPC2 20198422 PTHR12694:SF8 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;gene expression#GO:0010467;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 RNA metabolism protein#PC00031;general transcription factor#PC00259 General transcription regulation#P00023>TFIIA complex#P00662;Transcription regulation by bZIP transcription factor#P00055>TFIIA complex#P01390 HELRO|EnsemblGenome=HelroG110566|UniProtKB=T1EF32 T1EF32 20195184 PTHR11733:SF167 ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED FI17812P1-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Endothelin signaling pathway#P00019>ECE1-3#P00585 HELRO|EnsemblGenome=HelroG169139|UniProtKB=T1F1G3 T1F1G3 20202663 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157156|UniProtKB=T1EM72 T1EM72 20197672 PTHR11461:SF211 SERINE PROTEASE INHIBITOR, SERPIN GH10112P-RELATED protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG167491|UniProtKB=T1EZF3 T1EZF3 20201953 PTHR47055:SF3 DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 HELRO|EnsemblGenome=HelroG172579|UniProtKB=T1F5J8 T1F5J8 20204097 PTHR24393:SF15 ZINC FINGER PROTEIN IP01243P-RELATED DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG110414|UniProtKB=T1EF20 T1EF20 20195172 PTHR24073:SF858 DRAB5-RELATED DRAB5 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 localization#GO:0051179;organic substance transport#GO:0071702;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;protein transport#GO:0015031;nitrogen compound transport#GO:0071705;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG112638|UniProtKB=T1EFL0 T1EFL0 20195362 PTHR11532:SF93 PROTEASE M14 CARBOXYPEPTIDASE CARBOXYPEPTIDASE E metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metallocarboxypeptidase activity#GO:0004181;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;carboxypeptidase activity#GO:0004180 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG105284|UniProtKB=T1EDT0 T1EDT0 20194732 PTHR42884:SF3 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED FURIN-LIKE PROTEASE 1, ISOFORMS 1_1-X_2 hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 bounding membrane of organelle#GO:0098588;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791;Golgi membrane#GO:0000139 serine protease#PC00203;protein modifying enzyme#PC00260 Activin beta signaling pathway#P06210>FUR1#P06238;Endothelin signaling pathway#P00019>furin#P00575;GBB signaling pathway#P06214>FUR1#P06298;SCW signaling pathway#P06216>FUR1#P06333;DPP-SCW signaling pathway#P06212>FUR1#P06263;DPP signaling pathway#P06213>FUR1#P06290;ALP23B signaling pathway#P06209>FUR1#P06227;Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105;BMP/activin signaling pathway-drosophila#P06211>Furin#P06244;Alzheimer disease-presenilin pathway#P00004>Furin#P00157;MYO signaling pathway#P06215>FUR1#P06318 HELRO|EnsemblGenome=HelroG184608|UniProtKB=T1FLK8 T1FLK8 20209707 PTHR21396:SF2 39S RIBOSOMAL PROTEIN L43 LARGE RIBOSOMAL SUBUNIT PROTEIN ML43 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrial large ribosomal subunit#GO:0005762;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;organellar ribosome#GO:0000313;protein-containing complex#GO:0032991;large ribosomal subunit#GO:0015934;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840;mitochondrial protein-containing complex#GO:0098798 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG167179|UniProtKB=T1EZ38 T1EZ38 20201838 PTHR18945:SF925 NEUROTRANSMITTER GATED ION CHANNEL DUF4706 DOMAIN-CONTAINING PROTEIN ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG110679|UniProtKB=T1EF42 T1EF42 20195194 PTHR24092:SF150 PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE PHOSPHOLIPID-TRANSPORTING ATPASE ATPase-coupled intramembrane lipid transporter activity#GO:0140326;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;lipid transporter activity#GO:0005319 organophosphate ester transport#GO:0015748;macromolecule localization#GO:0033036;membrane organization#GO:0061024;transport#GO:0006810;cellular component organization#GO:0016043;regulation of membrane lipid distribution#GO:0097035;phospholipid transport#GO:0015914;cellular process#GO:0009987;lipid transport#GO:0006869;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;biological regulation#GO:0065007;lipid translocation#GO:0034204;lipid localization#GO:0010876;phospholipid translocation#GO:0045332 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG160174|UniProtKB=T1EPX3 T1EPX3 20198623 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183261|UniProtKB=T1FJD9 T1FJD9 20208938 PTHR22929:SF0 RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG194446|UniProtKB=T1FW24 T1FW24 20213020 PTHR22855:SF13 ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL ligase activity#GO:0016874;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;branched-chain amino acid metabolic process#GO:0009081;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;amino acid catabolic process#GO:0009063;small molecule catabolic process#GO:0044282;nitrogen compound metabolic process#GO:0006807;alpha-amino acid metabolic process#GO:1901605;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;cellular catabolic process#GO:0044248 protein-containing complex#GO:0032991;catalytic complex#GO:1902494 ligase#PC00142;metabolite interconversion enzyme#PC00262 Methylmalonyl pathway#P02755>Propionyl-CoA carboxylase#P03033;Succinate to proprionate conversion#P02777>Methylmalonyl-CoA decarboxylase#P03163 HELRO|EnsemblGenome=HelroG90849|UniProtKB=T1G7X0 T1G7X0 20217167 PTHR12027:SF91 WNT RELATED PROTO-ONCOGENE WNT-1 molecular function activator activity#GO:0140677;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;protein binding#GO:0005515;cytokine activity#GO:0005125;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;neurogenesis#GO:0022008;developmental process#GO:0032502;multicellular organism development#GO:0007275;cell communication#GO:0007154;cell fate commitment#GO:0045165;cell-cell signaling by wnt#GO:0198738;nervous system development#GO:0007399;cellular process#GO:0009987;regulation of biological process#GO:0050789;system development#GO:0048731;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;cell-cell signaling#GO:0007267;signaling#GO:0023052;canonical Wnt signaling pathway#GO:0060070;Wnt signaling pathway#GO:0016055 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Angiogenesis#P00005>Wnt#P00206;Cadherin signaling pathway#P00012>Wnt#P00474 HELRO|EnsemblGenome=HelroG184963|UniProtKB=T1FM76 T1FM76 20209925 PTHR43372:SF4 FATTY-ACID AMIDE HYDROLASE FATTY-ACID AMIDE HYDROLASE 2 cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG173066|UniProtKB=T1F6B3 T1F6B3 20204362 PTHR12059:SF5 RIBOSOMAL PROTEIN L23-RELATED LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;mitochondrial gene expression#GO:0140053;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;mitochondrial translation#GO:0032543;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrial large ribosomal subunit#GO:0005762;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;organellar ribosome#GO:0000313;protein-containing complex#GO:0032991;large ribosomal subunit#GO:0015934;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840;mitochondrial protein-containing complex#GO:0098798 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG177542|UniProtKB=T1FBV0 T1FBV0 20206299 PTHR46660:SF2 FAMILY NOT NAMED GLYCOSYLTRANSFERASE 1 DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG150086|UniProtKB=T1EKE3 T1EKE3 20197043 PTHR11607:SF3 ALPHA-MANNOSIDASE LYSOSOMAL ALPHA-MANNOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 glycosidase#PC00110;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG106233|UniProtKB=T1EE10 T1EE10 20194812 PTHR24083:SF46 NUCLEAR HORMONE RECEPTOR STEROID RECEPTOR SEVEN-UP, ISOFORM A cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;signaling receptor activity#GO:0038023;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG188549|UniProtKB=T1FQ40 T1FQ40 20210937 PTHR24412:SF480 KELCH PROTEIN KELCH-LIKE PROTEIN 8 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG193289|UniProtKB=T1FUU2 T1FUU2 20212588 PTHR22923:SF116 CEREBELLIN-RELATED C1Q DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG156671|UniProtKB=T1ELZ8 T1ELZ8 20197598 PTHR11561:SF0 PHOSPHOENOLPYRUVATE CARBOXYKINASE PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP]-RELATED cation binding#GO:0043169;carboxy-lyase activity#GO:0016831;carbon-carbon lyase activity#GO:0016830;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;lyase activity#GO:0016829;ion binding#GO:0043167 dicarboxylic acid metabolic process#GO:0043648;alcohol biosynthetic process#GO:0046165;lipid catabolic process#GO:0016042;response to extracellular stimulus#GO:0009991;acylglycerol metabolic process#GO:0006639;lipid biosynthetic process#GO:0008610;neutral lipid metabolic process#GO:0006638;triglyceride biosynthetic process#GO:0019432;carboxylic acid catabolic process#GO:0046395;cellular lipid catabolic process#GO:0044242;organic substance metabolic process#GO:0071704;organic hydroxy compound metabolic process#GO:1901615;oxoacid metabolic process#GO:0043436;response to oxygen-containing compound#GO:1901700;cellular response to organic substance#GO:0071310;cellular metabolic process#GO:0044237;alcohol metabolic process#GO:0006066;intracellular chemical homeostasis#GO:0055082;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;hexose biosynthetic process#GO:0019319;organic acid catabolic process#GO:0016054;response to glucose#GO:0009749;small molecule catabolic process#GO:0044282;response to stress#GO:0006950;small molecule biosynthetic process#GO:0044283;carbohydrate homeostasis#GO:0033500;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329;lipid metabolic process#GO:0006629;monosaccharide metabolic process#GO:0005996;response to lipid#GO:0033993;organic hydroxy compound biosynthetic process#GO:1901617;biosynthetic process#GO:0009058;cellular homeostasis#GO:0019725;cellular response to oxygen-containing compound#GO:1901701;glycerolipid metabolic process#GO:0046486;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carbohydrate metabolic process#GO:0005975;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;response to organic substance#GO:0010033;carbohydrate biosynthetic process#GO:0016051;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;triglyceride metabolic process#GO:0006641;glycerolipid biosynthetic process#GO:0045017;glucose homeostasis#GO:0042593;homeostatic process#GO:0042592;cellular biosynthetic process#GO:0044249;response to nutrient levels#GO:0031667;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;chemical homeostasis#GO:0048878;glucose metabolic process#GO:0006006;fatty acid catabolic process#GO:0009062;response to external stimulus#GO:0009605;response to stimulus#GO:0050896;intracellular glucose homeostasis#GO:0001678;fatty acid metabolic process#GO:0006631;response to chemical#GO:0042221;response to starvation#GO:0042594;hexose metabolic process#GO:0019318;cellular lipid metabolic process#GO:0044255;carboxylic acid metabolic process#GO:0019752 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 kinase#PC00137 Pyruvate metabolism#P02772>Phosphoenolpyruvate Carboxykinase#P03135 HELRO|EnsemblGenome=HelroG86766|UniProtKB=T1G6G7 T1G6G7 20216664 PTHR12103:SF15 5'-NUCLEOTIDASE DOMAIN-CONTAINING CYTOSOLIC PURINE 5'-NUCLEOTIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;5'-nucleotidase activity#GO:0008253;catalytic activity#GO:0003824;nucleotidase activity#GO:0008252;phosphoric ester hydrolase activity#GO:0042578 nucleotide phosphatase#PC00173;phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG185530|UniProtKB=T1FMX8 T1FMX8 20210177 PTHR10352:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG189270|UniProtKB=T1FQW4 T1FQW4 20211211 PTHR46378:SF1 STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN biological regulation#GO:0065007;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of lipid metabolic process#GO:0019216;regulation of lipid biosynthetic process#GO:0046890;regulation of biosynthetic process#GO:0009889;regulation of metabolic process#GO:0019222 membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG160687|UniProtKB=T1EQL6 T1EQL6 20198866 PTHR12766:SF10 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DAXX-LIKE PROTEIN molecular adaptor activity#GO:0060090;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;protein-macromolecule adaptor activity#GO:0030674 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG155811|UniProtKB=T1ELM6 T1ELM6 20197476 PTHR12434:SF6 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mediator complex#GO:0016592;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG78584|UniProtKB=T1G3D3 T1G3D3 20215581 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG178718|UniProtKB=T1FDM4 T1FDM4 20206923 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN SI:DKEY-17M8.2 HELRO|EnsemblGenome=HelroG185286|UniProtKB=T1FMM0 T1FMM0 20210069 PTHR19269:SF45 TROPOMYOSIN TROPOMYOSIN-1, ISOFORMS 33_34 cytoskeletal protein#PC00085;actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG88217|UniProtKB=T1G700 T1G700 20216847 PTHR16083:SF85 LEUCINE RICH REPEAT CONTAINING PROTEIN FI16115P1 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG188755|UniProtKB=T1FQB9 T1FQB9 20211016 PTHR15572:SF0 GLIOMA TUMOR SUPPRESSOR CANDIDATE REGION GENE 1 GLUTAMINE-RICH PROTEIN-RELATED positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;ATPase complex#GO:1904949;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;SWI/SNF complex#GO:0016514;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG108276|UniProtKB=T1EEH9 T1EEH9 20194981 PTHR11208:SF125 RNA-BINDING PROTEIN RELATED KH DOMAIN-CONTAINING RNA-BINDING PROTEIN QKI nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of RNA splicing#GO:0043484;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of mRNA processing#GO:0050684;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;regulation of mRNA metabolic process#GO:1903311 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG188065|UniProtKB=T1FPL5 T1FPL5 20210762 PTHR13723:SF306 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG156457|UniProtKB=T1ELX0 T1ELX0 20197570 PTHR23359:SF206 NUCLEOTIDE KINASE UMP-CMP KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, phosphate group as acceptor#GO:0016776;catalytic activity#GO:0003824;kinase activity#GO:0016301 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 nucleotide kinase#PC00172;kinase#PC00137 De novo pyrimidine ribonucleotides biosythesis#P02740>Uridylate kinase#P02924;De novo purine biosynthesis#P02738>Adenylate kinase#P02896;Salvage pyrimidine ribonucleotides#P02775>Cytidylate kinase#P03153 HELRO|EnsemblGenome=HelroG109647|UniProtKB=T1EEV4 T1EEV4 20195106 PTHR13937:SF0 EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED nucleic acid binding#GO:0003676;translation initiation factor binding#GO:0031369;translation regulator activity#GO:0045182;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation initiation factor activity#GO:0003743;protein binding#GO:0005515;translation regulator activity, nucleic acid binding#GO:0090079;translation factor activity, RNA binding#GO:0008135 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;translational initiation#GO:0006413;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;eukaryotic translation initiation factor 3 complex#GO:0005852;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG66091|UniProtKB=T1FYG9 T1FYG9 20213867 PTHR24012:SF812 RNA BINDING PROTEIN RNA-BINDING PROTEIN 45 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG124593|UniProtKB=T1EH20 T1EH20 20195870 PTHR22966:SF61 2-AMINOETHANETHIOL DIOXYGENASE 2-AMINOETHANETHIOL DIOXYGENASE HELRO|EnsemblGenome=HelroG186164|UniProtKB=T1FNR2 T1FNR2 20210459 PTHR24068:SF116 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN CONJUGATING ENZYME E2 L3 ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;catalytic activity#GO:0003824;ubiquitin-like protein ligase binding#GO:0044389;enzyme binding#GO:0019899;ubiquitin conjugating enzyme activity#GO:0061631;protein binding#GO:0005515;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin protein ligase binding#GO:0031625 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Parkinson disease#P00049>UbcH7#P01224;Parkinson disease#P00049>UbcH8#P01223;Ubiquitin proteasome pathway#P00060>E2#P01491 HELRO|EnsemblGenome=HelroG66664|UniProtKB=T1FYN6 T1FYN6 20213934 PTHR10766:SF55 TRANSMEMBRANE 9 SUPERFAMILY PROTEIN TRANSMEMBRANE 9 SUPERFAMILY MEMBER 4 localization#GO:0051179;localization within membrane#GO:0051668;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;cellular process#GO:0009987;protein localization#GO:0008104 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG169543|UniProtKB=T1F227 T1F227 20202877 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185865|UniProtKB=T1FND4 T1FND4 20210331 PTHR11851:SF226 METALLOPROTEASE CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL cellular localization#GO:0051641;mitochondrial protein processing#GO:0034982;macromolecule localization#GO:0033036;gene expression#GO:0010467;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;protein processing#GO:0016485;establishment of localization#GO:0051234;protein targeting to mitochondrion#GO:0006626;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein localization to organelle#GO:0033365;protein metabolic process#GO:0019538;protein processing involved in protein targeting to mitochondrion#GO:0006627;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein targeting#GO:0006605;cellular metabolic process#GO:0044237;establishment of protein localization to organelle#GO:0072594;protein maturation#GO:0051604;organonitrogen compound metabolic process#GO:1901564;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein localization to mitochondrion#GO:0070585;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;cellular macromolecule localization#GO:0070727;establishment of protein localization to mitochondrion#GO:0072655 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG158821|UniProtKB=T1ENB1 T1ENB1 20198061 PTHR19303:SF74 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG157124|UniProtKB=T1EM66 T1EM66 20197666 PTHR11661:SF2 60S RIBOSOMAL PROTEIN L12 LARGE RIBOSOMAL SUBUNIT PROTEIN UL11 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;rRNA binding#GO:0019843;binding#GO:0005488;organic cyclic compound binding#GO:0097159 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG185921|UniProtKB=T1FNF9 T1FNF9 20210356 PTHR22768:SF0 DNA REPLICATION COMPLEX GINS PROTEIN PSF3 DNA REPLICATION COMPLEX GINS PROTEIN PSF3 cellular aromatic compound metabolic process#GO:0006725;nuclear DNA replication#GO:0033260;heterocycle metabolic process#GO:0046483;macromolecule metabolic process#GO:0043170;cell cycle process#GO:0022402;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;mitotic cell cycle process#GO:1903047;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mitotic cell cycle#GO:0000278;mitotic DNA replication initiation#GO:1902975;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mitotic DNA replication#GO:1902969;DNA-templated DNA replication#GO:0006261;cell cycle#GO:0007049;DNA replication#GO:0006260;DNA replication initiation#GO:0006270;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;cell cycle DNA replication#GO:0044786 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;DNA replication preinitiation complex#GO:0031261;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;GINS complex#GO:0000811;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG153199|UniProtKB=T1EL08 T1EL08 20197258 PTHR47611:SF3 HAT DIMERISATION DOMAIN, C-TERMINAL HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192371|UniProtKB=T1FTV5 T1FTV5 20212252 PTHR23235:SF155 KRUEPPEL-LIKE TRANSCRIPTION FACTOR EARLY GROWTH RESPONSE 4-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG179612|UniProtKB=T1FEX8 T1FEX8 20207377 PTHR14949:SF54 EGF-LIKE-DOMAIN, MULTIPLE 7, 8 VWFD DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 anatomical structure development#GO:0048856;developmental process#GO:0032502 cell surface#GO:0009986;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG172158|UniProtKB=T1F531 T1F531 20203930 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG182257|UniProtKB=T1FI02 T1FI02 20208451 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG80106|UniProtKB=T1G3X8 T1G3X8 20215776 PTHR12834:SF12 SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN localization within membrane#GO:0051668;cotranslational protein targeting to membrane#GO:0006613;cellular localization#GO:0051641;protein localization to endoplasmic reticulum#GO:0070972;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;protein targeting#GO:0006605;establishment of protein localization to organelle#GO:0072594;protein targeting to ER#GO:0045047;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;SRP-dependent cotranslational protein targeting to membrane#GO:0006614;establishment of protein localization to membrane#GO:0090150;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein localization to organelle#GO:0033365;establishment of protein localization to endoplasmic reticulum#GO:0072599 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG194312|UniProtKB=T1FVX1 T1FVX1 20212967 PTHR24416:SF349 TYROSINE-PROTEIN KINASE RECEPTOR TYROSINE-PROTEIN KINASE RYK signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;regulation of cellular component organization#GO:0051128;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;regulation of plasma membrane bounded cell projection organization#GO:0120035;cell communication#GO:0007154;cellular process#GO:0009987;regulation of neuron projection development#GO:0010975;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;regulation of cell projection organization#GO:0031344;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG64399|UniProtKB=T1FXU3 T1FXU3 20213641 PTHR24345:SF93 SERINE/THREONINE-PROTEIN KINASE PLK SERINE_THREONINE-PROTEIN KINASE PLK1 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;mitotic spindle organization#GO:0007052;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;cell cycle#GO:0007049;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;spindle organization#GO:0007051;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047 supramolecular complex#GO:0099080;spindle pole#GO:0000922;microtubule organizing center#GO:0005815;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;kinetochore#GO:0000776;condensed chromosome, centromeric region#GO:0000779;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;centrosome#GO:0005813;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;chromosome#GO:0005694;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;chromosomal region#GO:0098687;cytoskeleton#GO:0005856;spindle#GO:0005819 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG158766|UniProtKB=T1EN85 T1EN85 20198035 PTHR11610:SF173 LIPASE LIPASE DOMAIN-CONTAINING PROTEIN-RELATED hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;lipid catabolic process#GO:0016042;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 lipase#PC00143;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG151216|UniProtKB=T1EKI8 T1EKI8 20197088 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG82913|UniProtKB=T1G4Y1 T1G4Y1 20216129 PTHR11920:SF501 GUANYLYL CYCLASE GUANYLATE CYCLASE 32E adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG186199|UniProtKB=T1FNT1 T1FNT1 20210478 PTHR12300:SF161 HVA22-LIKE PROTEINS RECEPTOR EXPRESSION-ENHANCING PROTEIN membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG189553|UniProtKB=T1FR52 T1FR52 20211299 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG186023|UniProtKB=T1FNK0 T1FNK0 20210397 PTHR11711:SF186 ADP RIBOSYLATION FACTOR-RELATED ADP RIBOSYLATION FACTOR-LIKE 4, ISOFORM B carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 G-protein#PC00020 Huntington disease#P00029>ARF#P00786 HELRO|EnsemblGenome=HelroG164551|UniProtKB=T1EVK4 T1EVK4 20200604 PTHR16029:SF11 CENTROSOMAL PROTEIN OF 192 KDA CENTROSOMAL PROTEIN OF 192 KDA enzyme binding#GO:0019899;protein binding#GO:0005515;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900 cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;mitotic spindle organization#GO:0007052;macromolecule localization#GO:0033036;nuclear division#GO:0000280;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;centrosome cycle#GO:0007098;microtubule cytoskeleton organization involved in mitosis#GO:1902850;mitotic cell cycle process#GO:1903047;chromosome segregation#GO:0007059;mitotic cell cycle#GO:0000278;mitotic spindle assembly#GO:0090307;spindle assembly#GO:0051225;mitotic nuclear division#GO:0140014;cytoskeleton organization#GO:0007010;mitotic sister chromatid segregation#GO:0000070;spindle organization#GO:0007051;protein localization to organelle#GO:0033365;non-membrane-bounded organelle assembly#GO:0140694;cellular component assembly#GO:0022607;nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule organizing center organization#GO:0031023;protein localization#GO:0008104;localization#GO:0051179;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;protein localization to cytoskeleton#GO:0044380;cellular macromolecule localization#GO:0070727;microtubule-based process#GO:0007017;chromosome organization#GO:0051276;organelle organization#GO:0006996;cell cycle#GO:0007049;organelle fission#GO:0048285 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;centriole#GO:0005814;organelle#GO:0043226;intracellular organelle#GO:0043229;centrosome#GO:0005813;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG182943|UniProtKB=T1FIY4 T1FIY4 20208783 PTHR31804:SF2 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15 CUE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG72599|UniProtKB=T1G124 T1G124 20214772 PTHR10366:SF564 NAD DEPENDENT EPIMERASE/DEHYDRATASE STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG161507|UniProtKB=T1ERK5 T1ERK5 20199205 PTHR12231:SF253 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG163706|UniProtKB=T1EUD6 T1EUD6 20200186 PTHR46954:SF1 C2H2-TYPE DOMAIN-CONTAINING PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180444|UniProtKB=T1FFX2 T1FFX2 20207721 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG189267|UniProtKB=T1FQW2 T1FQW2 20211209 PTHR43173:SF19 ABC1 FAMILY PROTEIN AARF DOMAIN-CONTAINING PROTEIN KINASE 1 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG162962|UniProtKB=T1ETF7 T1ETF7 20199857 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169080|UniProtKB=T1F1D5 T1F1D5 20202635 PTHR11214:SF3 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE BETA-1,3-GALACTOSYLTRANSFERASE 6 transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 cytoplasm#GO:0005737;bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;Golgi membrane#GO:0000139;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG169705|UniProtKB=T1F290 T1F290 20202940 PTHR23280:SF21 4.1 G PROTEIN PROTEIN 4.1 HOMOLOG cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG185548|UniProtKB=T1FMZ0 T1FMZ0 20210189 PTHR11711:SF322 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR 6 carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 G-protein#PC00020 Integrin signalling pathway#P00034>Arf6#P00919;Huntington disease#P00029>ARF#P00786 HELRO|EnsemblGenome=HelroG166674|UniProtKB=T1EYC3 T1EYC3 20201573 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157245|UniProtKB=T1EM87 T1EM87 20197687 PTHR10562:SF56 SMALL UBIQUITIN-RELATED MODIFIER SMALL UBIQUITIN-RELATED MODIFIER enzyme binding#GO:0019899;protein binding#GO:0005515;binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein sumoylation#GO:0016925;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG160995|UniProtKB=T1EQZ4 T1EQZ4 20198994 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184878|UniProtKB=T1FM43 T1FM43 20209892 PTHR43818:SF11 BCDNA.GH03377 BCDNA.GH03377 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG164068|UniProtKB=T1EUV4 T1EUV4 20200354 PTHR15718:SF3 G PROTEIN-REGULATED INDUCER OF NEURITE OUTGROWTH C-TERMINAL DOMAIN-CONTAINING PROTEIN G PROTEIN-REGULATED INDUCER OF NEURITE OUTGROWTH C-TERMINAL DOMAIN-CONTAINING PROTEIN cellular developmental process#GO:0048869;neurogenesis#GO:0022008;cell projection organization#GO:0030030;multicellular organism development#GO:0007275;developmental process#GO:0032502;cellular component organization#GO:0016043;cellular process#GO:0009987;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;system development#GO:0048731;neuron projection development#GO:0031175;cell differentiation#GO:0030154;anatomical structure development#GO:0048856;neuron differentiation#GO:0030182;neuron development#GO:0048666;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG163497|UniProtKB=T1EU48 T1EU48 20200098 PTHR23320:SF165 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MARVEL DOMAIN-CONTAINING PROTEIN transporter#PC00227 HELRO|EnsemblGenome=HelroG188924|UniProtKB=T1FQH4 T1FQH4 20211071 PTHR46491:SF3 CDGSH IRON SULFUR DOMAIN PROTEIN HOMOLOG CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL small molecule binding#GO:0036094;iron-sulfur cluster binding#GO:0051536;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG166532|UniProtKB=T1EY78 T1EY78 20201528 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED FMRFAMIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG172525|UniProtKB=T1F5G6 T1F5G6 20204065 PTHR33562:SF28 ATILLA, ISOFORM B-RELATED-RELATED PROTEIN QUIVER HELRO|EnsemblGenome=HelroG189599|UniProtKB=T1FR68 T1FR68 20211315 PTHR31840:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 97 COILED-COIL DOMAIN-CONTAINING PROTEIN 97 HELRO|EnsemblGenome=HelroG193445|UniProtKB=T1FUZ7 T1FUZ7 20212643 PTHR13748:SF31 COBW-RELATED ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG141093|UniProtKB=T1EJ26 T1EJ26 20196576 PTHR24303:SF31 HEME-BINDING MONOOXYGENASE FAMILY CYTOCHROME P450 307A1-RELATED oxygenase#PC00177 HELRO|EnsemblGenome=HelroG158625|UniProtKB=T1EN11 T1EN11 20197961 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN SI:DKEY-17M8.2 HELRO|EnsemblGenome=HelroG194306|UniProtKB=T1FVW9 T1FVW9 20212965 PTHR13453:SF1 KAT8 REGULATORY NSL COMPLEX SUBUNIT 2 KAT8 REGULATORY NSL COMPLEX SUBUNIT 2 histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;protein-DNA complex#GO:0032993;chromatin#GO:0000785;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;chromosome#GO:0005694 HELRO|EnsemblGenome=HelroG96898|UniProtKB=T1G9E3 T1G9E3 20217690 PTHR17149:SF4 NUCLEAR PROTEIN 1 AND 2 RH17958P negative regulation of biological process#GO:0048519;regulation of cell population proliferation#GO:0042127;regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;negative regulation of cell cycle#GO:0045786;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;negative regulation of cell population proliferation#GO:0008285;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG183148|UniProtKB=T1FJ76 T1FJ76 20208875 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG113404|UniProtKB=T1EFS3 T1EFS3 20195425 PTHR44489:SF11 FAMILY NOT NAMED WD REPEAT DOMAIN 86 HELRO|EnsemblGenome=HelroG191274|UniProtKB=T1FSU0 T1FSU0 20211887 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG63877|UniProtKB=T1FXL6 T1FXL6 20213564 PTHR43840:SF13 MITOCHONDRIAL METAL TRANSPORTER 1-RELATED CATION EFFLUX PROTEIN CYTOPLASMIC DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG72062|UniProtKB=T1G0U8 T1G0U8 20214696 PTHR24329:SF543 HOMEOBOX PROTEIN ARISTALESS FI01017P-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG72217|UniProtKB=T1G0X4 T1G0X4 20214722 PTHR42643:SF30 IONOTROPIC RECEPTOR 20A-RELATED IONOTROPIC RECEPTOR 40A-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG186153|UniProtKB=T1FNQ7 T1FNQ7 20210454 PTHR11353:SF22 CHAPERONIN T-COMPLEX PROTEIN 1 SUBUNIT ETA protein binding#GO:0005515;unfolded protein binding#GO:0051082;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;chaperonin-containing T-complex#GO:0005832;protein folding chaperone complex#GO:0101031;intracellular anatomical structure#GO:0005622 chaperonin#PC00073 HELRO|EnsemblGenome=HelroG169706|UniProtKB=T1F291 T1F291 20202941 PTHR12482:SF67 LIPASE ROG1-RELATED-RELATED DUF676 DOMAIN-CONTAINING PROTEIN lipid metabolic process#GO:0006629;cellular metabolic process#GO:0044237;cellular process#GO:0009987;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG186237|UniProtKB=T1FNU9 T1FNU9 20210496 PTHR33538:SF2 PROTEIN GAMETE EXPRESSED 1 PROTEIN GAMETE EXPRESSED 1 HELRO|EnsemblGenome=HelroG192212|UniProtKB=T1FTP7 T1FTP7 20212194 PTHR19384:SF84 NITRIC OXIDE SYNTHASE-RELATED METHIONINE SYNTHASE REDUCTASE carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;oxidoreductase activity, acting on metal ions#GO:0016722;nucleoside phosphate binding#GO:1901265;flavin adenine dinucleotide binding#GO:0050660;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168;oxidoreductase activity#GO:0016491 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;sulfur compound metabolic process#GO:0006790;proteinogenic amino acid biosynthetic process#GO:0170038;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;aspartate family amino acid biosynthetic process#GO:0009067;alpha-amino acid biosynthetic process#GO:1901607;nitrogen compound metabolic process#GO:0006807;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;aspartate family amino acid metabolic process#GO:0009066;small molecule biosynthetic process#GO:0044283;L-amino acid biosynthetic process#GO:0170034;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG192286|UniProtKB=T1FTS7 T1FTS7 20212224 PTHR23103:SF15 ALZHEIMER'S DISEASE BETA-AMYLOID RELATED AMYLOID-BETA-LIKE PROTEIN protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG176934|UniProtKB=T1FB22 T1FB22 20206021 PTHR24248:SF125 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR DOPAMINE D2-LIKE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG159493|UniProtKB=T1EP35 T1EP35 20198335 PTHR31802:SF49 32 KDA HEAT SHOCK PROTEIN-RELATED TRANSMEMBRANE PROTEIN HELRO|EnsemblGenome=HelroG131255|UniProtKB=T1EHV6 T1EHV6 20196156 PTHR24416:SF550 TYROSINE-PROTEIN KINASE RECEPTOR FIBROBLAST GROWTH FACTOR RECEPTOR HOMOLOG 1-RELATED signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG62743|UniProtKB=T1FX45 T1FX45 20213393 PTHR23304:SF183 SPOT2-RELATED T. BRUCEI SPP.-SPECIFIC PROTEIN HELRO|EnsemblGenome=HelroG96321|UniProtKB=T1G9B3 T1G9B3 20217660 PTHR12737:SF9 DIMETHYLARGININE DIMETHYLAMINOHYDROLASE DIMETHYLARGININASE amino acid binding#GO:0016597;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;carboxylic acid binding#GO:0031406;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;anion binding#GO:0043168;ion binding#GO:0043167;organic acid binding#GO:0043177 positive regulation of nitrogen compound metabolic process#GO:0051173;oxoacid metabolic process#GO:0043436;regulation of nitrogen compound metabolic process#GO:0051171;arginine metabolic process#GO:0006525;positive regulation of cellular metabolic process#GO:0031325;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;alpha-amino acid metabolic process#GO:1901605;carboxylic acid metabolic process#GO:0019752;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;amino acid metabolic process#GO:0006520;regulation of cellular metabolic process#GO:0031323;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG171313|UniProtKB=T1F433 T1F433 20203582 PTHR44755:SF8 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide hormone binding#GO:0017046;hormone binding#GO:0042562;binding#GO:0005488;peptide binding#GO:0042277;amide binding#GO:0033218 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG65318|UniProtKB=T1FY60 T1FY60 20213758 PTHR12791:SF37 GOLGI SNARE BET1-RELATED BET1-LIKE PROTEIN molecular adaptor activity#GO:0060090;SNAP receptor activity#GO:0005484;protein-macromolecule adaptor activity#GO:0030674 endosomal transport#GO:0016197;cellular localization#GO:0051641;transport#GO:0006810;regulation of localization#GO:0032879;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;cytosolic transport#GO:0016482;regulation of vesicle-mediated transport#GO:0060627;retrograde transport, endosome to Golgi#GO:0042147;regulation of biological process#GO:0050789;localization#GO:0051179;regulation of transport#GO:0051049;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 SNARE complex#GO:0031201;cytoplasm#GO:0005737;membrane protein complex#GO:0098796;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034 HELRO|EnsemblGenome=HelroG178411|UniProtKB=T1FD49 T1FD49 20206748 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG185017|UniProtKB=T1FMA2 T1FMA2 20209951 PTHR12439:SF11 PLACENTAL PROTEIN 11-RELATED URIDYLATE-SPECIFIC ENDORIBONUCLEASE HELRO|EnsemblGenome=HelroG71626|UniProtKB=T1G0P3 T1G0P3 20214641 PTHR45638:SF7 CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A CYCLIC NUCLEOTIDE-GATED ION CHANNEL-LIKE, ISOFORM E protein-containing complex binding#GO:0044877;binding#GO:0005488 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG172398|UniProtKB=T1F596 T1F596 20203995 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG177176|UniProtKB=T1FBB7 T1FBB7 20206116 PTHR11304:SF29 EPHRIN EPHRIN protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 neuron projection guidance#GO:0097485;signal transduction#GO:0007165;neurogenesis#GO:0022008;cell projection organization#GO:0030030;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;regulation of biological process#GO:0050789;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;axonogenesis#GO:0007409;plasma membrane bounded cell projection morphogenesis#GO:0120039;signaling#GO:0023052;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;multicellular organism development#GO:0007275;cell morphogenesis#GO:0000902;cellular component organization#GO:0016043;cell communication#GO:0007154;cellular process#GO:0009987;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;neuron projection development#GO:0031175;axon development#GO:0061564;enzyme-linked receptor protein signaling pathway#GO:0007167;cell morphogenesis involved in neuron differentiation#GO:0048667;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 membrane-bound signaling molecule#PC00152;intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG123857|UniProtKB=T1EGZ4 T1EGZ4 20195844 PTHR11741:SF0 ELONGATION FACTOR TS ELONGATION FACTOR TS, MITOCHONDRIAL nucleic acid binding#GO:0003676;translation regulator activity#GO:0045182;translation regulator activity, nucleic acid binding#GO:0090079;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation elongation factor activity#GO:0003746;translation factor activity, RNA binding#GO:0008135 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;translational elongation#GO:0006414;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 translation elongation factor#PC00222;translational protein#PC00263 HELRO|EnsemblGenome=HelroG190314|UniProtKB=T1FRW3 T1FRW3 20211560 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG191720|UniProtKB=T1FT82 T1FT82 20212029 PTHR21597:SF0 THO2 PROTEIN THO COMPLEX SUBUNIT 2 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;mRNA transport#GO:0051028;RNA localization#GO:0006403;localization#GO:0051179;organic substance transport#GO:0071702;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;THO complex#GO:0000347;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;transcription export complex#GO:0000346;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG167653|UniProtKB=T1EZM6 T1EZM6 20202026 PTHR24203:SF45 ANKYRIN REPEAT FAMILY PROTEIN ANKYRIN REPEAT DOMAIN 6 HELRO|EnsemblGenome=HelroG83454|UniProtKB=T1G557 T1G557 20216205 PTHR13137:SF6 DC11 ACN9 HOMOLOG SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL oxoacid metabolic process#GO:0043436;cellular component assembly#GO:0022607;dicarboxylic acid metabolic process#GO:0043648;cellular component biogenesis#GO:0044085;mitochondrial respiratory chain complex assembly#GO:0033108;protein-containing complex assembly#GO:0065003;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;cellular component organization or biogenesis#GO:0071840;mitochondrial respiratory chain complex II assembly#GO:0034553;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;mitochondrion organization#GO:0007005;carboxylic acid metabolic process#GO:0019752;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 envelope#GO:0031975;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;mitochondrial envelope#GO:0005740;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;mitochondrial intermembrane space#GO:0005758;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185403|UniProtKB=T1FMR7 T1FMR7 20210116 PTHR12694:SF8 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;gene expression#GO:0010467;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 RNA metabolism protein#PC00031;general transcription factor#PC00259 General transcription regulation#P00023>TFIIA complex#P00662;Transcription regulation by bZIP transcription factor#P00055>TFIIA complex#P01390 HELRO|EnsemblGenome=HelroG180273|UniProtKB=T1FFN6 T1FFN6 20207635 PTHR35836:SF1 VCBS REPEAT-CONTAINING PROTEIN VCBS REPEAT-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159691|UniProtKB=T1EPB3 T1EPB3 20198413 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG126929|UniProtKB=T1EHB8 T1EHB8 20195968 PTHR23430:SF371 HISTONE H2A HISTONE H2A nucleosome binding#GO:0031491;nucleic acid binding#GO:0003676;chromatin DNA binding#GO:0031490;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;protein-containing complex binding#GO:0044877 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;protein-DNA complex organization#GO:0071824;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;heterochromatin formation#GO:0031507;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;negative regulation of gene expression, epigenetic#GO:0045814;cellular process#GO:0009987;epigenetic regulation of gene expression#GO:0040029;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;heterochromatin organization#GO:0070828;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG89801|UniProtKB=T1G7H8 T1G7H8 20217025 PTHR10827:SF98 RETICULOCALBIN 45 KDA CALCIUM-BINDING PROTEIN calmodulin-related#PC00061 Gonadotropin-releasing hormone receptor pathway#P06664>AMPK#P06830 HELRO|EnsemblGenome=HelroG97359|UniProtKB=T1G9G5 T1G9G5 20217712 PTHR24251:SF37 OVOCHYMASE-RELATED CUB DOMAIN-CONTAINING PROTEIN serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG69189|UniProtKB=T1FZQ7 T1FZQ7 20214305 PTHR28583:SF1 ACID AMIDASE ACID CERAMIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity#GO:0003824 cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG102728|UniProtKB=T1EDB2 T1EDB2 20194564 PTHR19288:SF44 4-NITROPHENYLPHOSPHATASE-RELATED PHOSPHOLYSINE PHOSPHOHISTIDINE INORGANIC PYROPHOSPHATE PHOSPHATASE pyrophosphatase activity#GO:0016462;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;phosphoric ester hydrolase activity#GO:0042578 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG183221|UniProtKB=T1FJC1 T1FJC1 20208920 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG184072|UniProtKB=T1FKJ1 T1FKJ1 20209340 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG192423|UniProtKB=T1FTY1 T1FTY1 20212278 PTHR12412:SF2 CAP BINDING PROTEIN NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA cap binding#GO:0000339;binding#GO:0005488;organic cyclic compound binding#GO:0097159 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;mRNA catabolic process#GO:0006402;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;negative regulation of cellular process#GO:0048523;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;nuclear-transcribed mRNA catabolic process#GO:0000956;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG184530|UniProtKB=T1FLE7 T1FLE7 20209646 PTHR33332:SF48 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163102|UniProtKB=T1ETN4 T1ETN4 20199934 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG161238|UniProtKB=T1ER88 T1ER88 20199088 PTHR37162:SF1 HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED BED-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166478|UniProtKB=T1EY62 T1EY62 20201512 PTHR13143:SF6 TETRATRICOPEPTIDE REPEAT PROTEIN 19 TETRATRICOPEPTIDE REPEAT PROTEIN 19, MITOCHONDRIAL cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrial respiratory chain complex III assembly#GO:0034551;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;cytochrome complex assembly#GO:0017004;protein-containing complex assembly#GO:0065003;mitochondrion organization#GO:0007005;cellular component organization#GO:0016043;cellular process#GO:0009987 envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG194795|UniProtKB=T1FWF1 T1FWF1 20213146 PTHR13483:SF3 BOX C_D SNORNA PROTEIN 1-RELATED BOX C_D SNORNA PROTEIN 1 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;biosynthetic process#GO:0009058;ribosomal large subunit biogenesis#GO:0042273;nucleobase-containing compound metabolic process#GO:0006139;RNA localization#GO:0006403;protein-RNA complex assembly#GO:0022618;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;ribosome biogenesis#GO:0042254;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;protein-RNA complex organization#GO:0071826;maturation of LSU-rRNA#GO:0000470 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG194385|UniProtKB=T1FW01 T1FW01 20212997 PTHR11071:SF561 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;catalytic activity#GO:0003824;peptide binding#GO:0042277;amide binding#GO:0033218 macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein peptidyl-prolyl isomerization#GO:0000413;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG168557|UniProtKB=T1F0Q4 T1F0Q4 20202404 PTHR14309:SF12 EXPRESSED PROTEIN PH DOMAIN-CONTAINING PROTEIN biological regulation#GO:0065007;regulation of biological process#GO:0050789;regulation of cell differentiation#GO:0045595;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG158881|UniProtKB=T1END1 T1END1 20198081 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG74739|UniProtKB=T1G1V1 T1G1V1 20215049 PTHR45620:SF42 PDF RECEPTOR-LIKE PROTEIN-RELATED G-PROTEIN COUPLED RECEPTOR SEB-2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG65590|UniProtKB=T1FYA4 T1FYA4 20213802 PTHR15104:SF0 DIHYDROPTERIDINE REDUCTASE DIHYDROPTERIDINE REDUCTASE nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;oxidoreductase activity#GO:0016491 cellular aromatic compound metabolic process#GO:0006725;alcohol biosynthetic process#GO:0046165;organonitrogen compound catabolic process#GO:1901565;organic hydroxy compound biosynthetic process#GO:1901617;biosynthetic process#GO:0009058;amino acid catabolic process#GO:0009063;organic cyclic compound metabolic process#GO:1901360;aromatic amino acid metabolic process#GO:0009072;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;alpha-amino acid metabolic process#GO:1901605;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;L-amino acid metabolic process#GO:0170033;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248;organic hydroxy compound metabolic process#GO:1901615;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;alcohol metabolic process#GO:0006066;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;aromatic compound catabolic process#GO:0019439;organic cyclic compound catabolic process#GO:1901361;aromatic compound biosynthetic process#GO:0019438;small molecule biosynthetic process#GO:0044283;carboxylic acid metabolic process#GO:0019752;aromatic amino acid family catabolic process#GO:0009074;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG191942|UniProtKB=T1FTF5 T1FTF5 20212102 PTHR24350:SF0 SERINE/THREONINE-PROTEIN KINASE IAL-RELATED AURORA KINASE mitotic spindle organization#GO:0007052;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;regulation of cell division#GO:0051302;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047;regulation of cell cycle process#GO:0010564;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;microtubule-based process#GO:0007017;regulation of cellular process#GO:0050794;organelle organization#GO:0006996;biological regulation#GO:0065007;cell cycle#GO:0007049;cytoskeleton organization#GO:0007010;regulation of cell cycle#GO:0051726;spindle organization#GO:0007051;regulation of cytokinesis#GO:0032465 supramolecular complex#GO:0099080;spindle midzone#GO:0051233;spindle microtubule#GO:0005876;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;microtubule#GO:0005874;spindle#GO:0005819 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG190425|UniProtKB=T1FRZ5 T1FRZ5 20211592 PTHR47385:SF24 CALPONIN MUSCLE-SPECIFIC PROTEIN 20 cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG66850|UniProtKB=T1FYR9 T1FYR9 20213967 PTHR11947:SF20 PYRUVATE DEHYDROGENASE KINASE [3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE, MITOCHONDRIAL transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;regulation of metabolic process#GO:0019222;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG67129|UniProtKB=T1FYW8 T1FYW8 20214016 PTHR11035:SF3 VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;monocarboxylic acid biosynthetic process#GO:0072330;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;organic acid metabolic process#GO:0006082;membrane lipid biosynthetic process#GO:0046467;sphingolipid metabolic process#GO:0006665;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;fatty acid metabolic process#GO:0006631;membrane lipid metabolic process#GO:0006643;nitrogen compound metabolic process#GO:0006807;small molecule biosynthetic process#GO:0044283;cellular lipid metabolic process#GO:0044255;carboxylic acid metabolic process#GO:0019752;sphingolipid biosynthetic process#GO:0030148;fatty acid biosynthetic process#GO:0006633;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG194076|UniProtKB=T1FVN1 T1FVN1 20212877 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG175779|UniProtKB=T1F9N2 T1F9N2 20205531 PTHR33395:SF21 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED PERICARDIN heart morphogenesis#GO:0003007;system development#GO:0048731;heart development#GO:0007507;circulatory system development#GO:0072359;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;animal organ development#GO:0048513;multicellular organism development#GO:0007275;developmental process#GO:0032502;animal organ morphogenesis#GO:0009887;multicellular organismal process#GO:0032501;cell adhesion#GO:0007155;cellular process#GO:0009987;post-embryonic development#GO:0009791 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG189192|UniProtKB=T1FQR7 T1FQR7 20211164 PTHR24039:SF52 FIBRILLIN-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG159895|UniProtKB=T1EPI5 T1EPI5 20198485 PTHR24178:SF9 MOLTING PROTEIN MLT-4 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG116537|UniProtKB=T1EGF7 T1EGF7 20195659 PTHR38537:SF8 JITTERBUG, ISOFORM N FILAMIN-A HELRO|EnsemblGenome=HelroG161257|UniProtKB=T1ER96 T1ER96 20199096 PTHR22974:SF21 MIXED LINEAGE PROTEIN KINASE DUAL SPECIFICITY PROTEIN KINASE TTK transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 negative regulation of sister chromatid segregation#GO:0033046;cellular localization#GO:0051641;regulation of mitotic nuclear division#GO:0007088;regulation of chromosome segregation#GO:0051983;mitotic cell cycle checkpoint signaling#GO:0007093;negative regulation of chromosome organization#GO:2001251;negative regulation of mitotic nuclear division#GO:0045839;regulation of cellular component organization#GO:0051128;negative regulation of nuclear division#GO:0051784;negative regulation of mitotic sister chromatid segregation#GO:0033048;chromosome segregation#GO:0007059;regulation of biological process#GO:0050789;cell cycle checkpoint signaling#GO:0000075;mitotic cell cycle#GO:0000278;nitrogen compound metabolic process#GO:0006807;regulation of mitotic sister chromatid segregation#GO:0033047;reproductive process#GO:0022414;intracellular signal transduction#GO:0035556;negative regulation of cellular component organization#GO:0051129;organic substance metabolic process#GO:0071704;negative regulation of cell cycle#GO:0045786;meiotic cell cycle#GO:0051321;regulation of mitotic cell cycle phase transition#GO:1901990;macromolecule metabolic process#GO:0043170;regulation of organelle organization#GO:0033043;mitotic spindle assembly checkpoint signaling#GO:0007094;negative regulation of chromosome segregation#GO:0051985;regulation of cell cycle phase transition#GO:1901987;cellular metabolic process#GO:0044237;cell communication#GO:0007154;regulation of mitotic metaphase/anaphase transition#GO:0030071;primary metabolic process#GO:0044238;regulation of cell cycle process#GO:0010564;protein localization#GO:0008104;cellular macromolecule localization#GO:0070727;reproduction#GO:0000003;regulation of cellular process#GO:0050794;sexual reproduction#GO:0019953;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100;negative regulation of mitotic sister chromatid separation#GO:2000816;signal transduction#GO:0007165;negative regulation of biological process#GO:0048519;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;macromolecule localization#GO:0033036;macromolecule modification#GO:0043412;regulation of chromosome separation#GO:1905818;cell cycle process#GO:0022402;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;negative regulation of cell cycle process#GO:0010948;peptidyl-serine phosphorylation#GO:0018105;mitotic cell cycle process#GO:1903047;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;negative regulation of mitotic cell cycle phase transition#GO:1901991;protein localization to kinetochore#GO:0034501;meiotic cell cycle process#GO:1903046;negative regulation of organelle organization#GO:0010639;protein localization to organelle#GO:0033365;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;signaling#GO:0023052;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;regulation of chromosome organization#GO:0033044;cellular response to stimulus#GO:0051716;regulation of mitotic sister chromatid separation#GO:0010965;regulation of nuclear division#GO:0051783;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;negative regulation of cell cycle phase transition#GO:1901988;organonitrogen compound metabolic process#GO:1901564;negative regulation of mitotic cell cycle#GO:0045930;protein phosphorylation#GO:0006468;cellular process#GO:0009987;localization#GO:0051179;response to stimulus#GO:0050896;negative regulation of chromosome separation#GO:1905819;regulation of meiotic cell cycle#GO:0051445;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;peptidyl-serine modification#GO:0018209;regulation of sister chromatid segregation#GO:0033045;regulation of mitotic cell cycle#GO:0007346 supramolecular complex#GO:0099080;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;kinetochore#GO:0000776;condensed chromosome, centromeric region#GO:0000779;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;chromosomal region#GO:0098687 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG167076|UniProtKB=T1EYZ5 T1EYZ5 20201795 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG193668|UniProtKB=T1FV88 T1FV88 20212734 PTHR22175:SF0 SMALL ACIDIC PROTEIN-RELATED SMALL ACIDIC PROTEIN HELRO|EnsemblGenome=HelroG184339|UniProtKB=T1FL10 T1FL10 20209509 PTHR33958:SF1 PROTEIN C8ORF37 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 418 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG168549|UniProtKB=T1F0P9 T1F0P9 20202399 PTHR21683:SF3 COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE-RELATED CILIA AND FLAGELLA ASSOCIATED PROTEIN 100 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG185480|UniProtKB=T1FMV6 T1FMV6 20210155 PTHR12831:SF0 TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;nucleotide-excision repair#GO:0006289;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;serine/threonine protein kinase complex#GO:1902554;RNA polymerase II transcription regulator complex#GO:0090575;protein kinase complex#GO:1902911;transcription factor TFIIH core complex#GO:0000439;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase II, holoenzyme#GO:0016591;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;transcription factor TFIIH holo complex#GO:0005675;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;general transcription factor#PC00259 Transcription regulation by bZIP transcription factor#P00055>TFIIH complex#P01392;General transcription regulation#P00023>TFIIH complex#P00664 HELRO|EnsemblGenome=HelroG179147|UniProtKB=T1FE90 T1FE90 20207139 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG85220|UniProtKB=T1G5U4 T1G5U4 20216441 PTHR12740:SF4 JNK1/MAPK8-ASSOCIATED MEMBRANE PROTEIN JNK1_MAPK8-ASSOCIATED MEMBRANE PROTEIN enzyme binding#GO:0019899;protein binding#GO:0005515;ubiquitin protein ligase binding#GO:0031625;binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389 response to organic substance#GO:0010033;macromolecule catabolic process#GO:0009057;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;response to organonitrogen compound#GO:0010243;ERAD pathway#GO:0036503;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG105555|UniProtKB=T1EDW2 T1EDW2 20194764 PTHR19308:SF8 PHOSPHATIDYLCHOLINE TRANSFER PROTEIN STAR-RELATED LIPID TRANSFER PROTEIN 7, MITOCHONDRIAL HELRO|EnsemblGenome=HelroG84516|UniProtKB=T1G5J5 T1G5J5 20216342 PTHR24418:SF373 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE SRC42A protein tyrosine kinase activity#GO:0004713;non-membrane spanning protein tyrosine kinase activity#GO:0004715;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein binding#GO:0005515;catalytic activity, acting on a protein#GO:0140096;signaling receptor binding#GO:0005102;kinase activity#GO:0016301;protein kinase activity#GO:0004672 response to external biotic stimulus#GO:0043207;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;immune response#GO:0006955;developmental process#GO:0032502;cell communication#GO:0007154;cellular process#GO:0009987;defense response to symbiont#GO:0140546;regulation of biological process#GO:0050789;immune system process#GO:0002376;response to stimulus#GO:0050896;response to external stimulus#GO:0009605;cell differentiation#GO:0030154;enzyme-linked receptor protein signaling pathway#GO:0007167;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to other organism#GO:0098542;regulation of cellular process#GO:0050794;response to other organism#GO:0051707;cell surface receptor signaling pathway#GO:0007166;biological process involved in interspecies interaction between organisms#GO:0044419;biological regulation#GO:0065007;innate immune response#GO:0045087;defense response#GO:0006952;signaling#GO:0023052;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169 non-receptor tyrosine protein kinase#PC00168 Parkinson disease#P00049>Src kinase#P01230;Integrin signalling pathway#P00034>Src#P00940 HELRO|EnsemblGenome=HelroG182050|UniProtKB=T1FHN4 T1FHN4 20208333 PTHR19282:SF544 TETRASPANIN TETRASPANIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG187814|UniProtKB=T1FPE3 T1FPE3 20210690 PTHR11384:SF62 ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 3 carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;ATPase-coupled transmembrane transporter activity#GO:0042626;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;lipid transporter activity#GO:0005319;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;ATP binding#GO:0005524 lipid metabolic process#GO:0006629;monocarboxylic acid transport#GO:0015718;cellular localization#GO:0051641;macromolecule localization#GO:0033036;organic acid transport#GO:0015849;fatty acid transport#GO:0015908;transport#GO:0006810;lipid catabolic process#GO:0016042;lipid modification#GO:0030258;lipid transport#GO:0006869;carboxylic acid transmembrane transport#GO:1905039;organic substance transport#GO:0071702;establishment of localization#GO:0051234;fatty acid beta-oxidation#GO:0006635;catabolic process#GO:0009056;lipid localization#GO:0010876;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;cellular lipid catabolic process#GO:0044242;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;intracellular lipid transport#GO:0032365;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;transmembrane transport#GO:0055085;organic anion transport#GO:0015711;cellular metabolic process#GO:0044237;carboxylic acid transport#GO:0046942;lipid oxidation#GO:0034440;cellular component organization#GO:0016043;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;fatty acid catabolic process#GO:0009062;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic acid catabolic process#GO:0016054;fatty acid metabolic process#GO:0006631;small molecule catabolic process#GO:0044282;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;organic acid transmembrane transport#GO:1903825;intracellular transport#GO:0046907;cellular lipid metabolic process#GO:0044255;carboxylic acid metabolic process#GO:0019752;peroxisome organization#GO:0007031;long-chain fatty acid transport#GO:0015909;monocarboxylic acid catabolic process#GO:0072329;small molecule metabolic process#GO:0044281 bounding membrane of organelle#GO:0098588;peroxisomal membrane#GO:0005778;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;peroxisome#GO:0005777;microbody#GO:0042579;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG127547|UniProtKB=T1EHF3 T1EHF3 20196001 PTHR15710:SF214 E3 UBIQUITIN-PROTEIN LIGASE PRAJA RING-TYPE DOMAIN-CONTAINING PROTEIN ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG179141|UniProtKB=T1FE84 T1FE84 20207133 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED BRCT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169884|UniProtKB=T1F2E5 T1F2E5 20202995 PTHR19317:SF0 PRENYLATED RAB ACCEPTOR 1-RELATED PRENYLATED RAB ACCEPTOR PROTEIN 1 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG105953|UniProtKB=T1EDY8 T1EDY8 20194790 PTHR11915:SF447 SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN SPECTRIN BETA CHAIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;organelle organization#GO:0006996 cortical cytoskeleton#GO:0030863;cell junction#GO:0030054;cellular anatomical entity#GO:0110165;cell cortex#GO:0005938;cell periphery#GO:0071944;cortical actin cytoskeleton#GO:0030864;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cell projection#GO:0042995;plasma membrane#GO:0005886 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG191252|UniProtKB=T1FSS9 T1FSS9 20211876 PTHR10648:SF4 SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888 macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;dephosphorylation#GO:0016311;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;protein metabolic process#GO:0019538;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 phosphatase modulator#PC00184 FGF signaling pathway#P00021>PP2A#P00629 HELRO|EnsemblGenome=HelroG152187|UniProtKB=T1EKQ0 T1EKQ0 20197150 PTHR15283:SF4 GREMLIN 1 BURSICON molecular function activator activity#GO:0140677;binding#GO:0005488;molecular function regulator activity#GO:0098772;cytokine binding#GO:0019955;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;protein binding#GO:0005515;signaling receptor binding#GO:0005102 regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;negative regulation of response to stimulus#GO:0048585;animal organ development#GO:0048513;developmental process#GO:0032502;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of BMP signaling pathway#GO:0030510;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;negative regulation of BMP signaling pathway#GO:0030514;anatomical structure morphogenesis#GO:0009653;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;animal organ morphogenesis#GO:0009887;regulation of cellular response to growth factor stimulus#GO:0090287;negative regulation of signal transduction#GO:0009968;negative regulation of cellular process#GO:0048523;negative regulation of cell communication#GO:0010648 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 HELRO|EnsemblGenome=HelroG84296|UniProtKB=T1G5H2 T1G5H2 20216319 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG158578|UniProtKB=T1EMY8 T1EMY8 20197938 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177767|UniProtKB=T1FC80 T1FC80 20206429 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG191187|UniProtKB=T1FSQ3 T1FSQ3 20211850 PTHR10372:SF27 PLAKOPHILLIN-RELATED ADHERENS JUNCTION PROTEIN P120 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cell-cell junction#GO:0005911;anchoring junction#GO:0070161;cell junction#GO:0030054;membrane-bounded organelle#GO:0043227;adherens junction#GO:0005912;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 intermediate filament binding protein#PC00130;intermediate filament#PC00129 HELRO|EnsemblGenome=HelroG107531|UniProtKB=T1EEA9 T1EEA9 20194911 PTHR24055:SF484 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Wnt signaling pathway#P00057>Nemo-like Kinase#P01449 HELRO|EnsemblGenome=HelroG182457|UniProtKB=T1FI82 T1FI82 20208531 PTHR17602:SF4 RIBOSOME BIOGENESIS REGULATORY PROTEIN RIBOSOME BIOGENESIS REGULATORY PROTEIN HOMOLOG cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;ribosomal large subunit biogenesis#GO:0042273;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;ribosome biogenesis#GO:0042254;maturation of 5.8S rRNA#GO:0000460;endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000447;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;preribosome, large subunit precursor#GO:0030687;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG185013|UniProtKB=T1FMA0 T1FMA0 20209949 PTHR11630:SF43 DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER DNA REPLICATION LICENSING FACTOR MCM6 ATP-dependent activity, acting on DNA#GO:0008094;nucleic acid binding#GO:0003676;3'-5' DNA helicase activity#GO:0043138;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;single-stranded DNA binding#GO:0003697;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;catalytic activity, acting on a nucleic acid#GO:0140640;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097;single-stranded DNA helicase activity#GO:0017116 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;double-strand break repair#GO:0006302;cell cycle process#GO:0022402;nucleobase-containing compound metabolic process#GO:0006139;mitotic cell cycle process#GO:1903047;DNA geometric change#GO:0032392;DNA damage response#GO:0006974;mitotic cell cycle#GO:0000278;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;recombinational repair#GO:0000725;DNA duplex unwinding#GO:0032508;DNA-templated DNA replication#GO:0006261;cell cycle DNA replication#GO:0044786;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;nuclear DNA replication#GO:0033260;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;DNA unwinding involved in DNA replication#GO:0006268;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;double-strand break repair via homologous recombination#GO:0000724;cellular process#GO:0009987;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;DNA conformation change#GO:0071103;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;double-strand break repair via break-induced replication#GO:0000727;organelle organization#GO:0006996;chromosome organization#GO:0051276;mitotic DNA replication#GO:1902969;cell cycle#GO:0007049;cellular response to stress#GO:0033554;DNA replication#GO:0006260;DNA metabolic process#GO:0006259 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;MCM complex#GO:0042555;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG72682|UniProtKB=T1G138 T1G138 20214786 PTHR45871:SF1 N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A HELRO|EnsemblGenome=HelroG179209|UniProtKB=T1FED0 T1FED0 20207179 PTHR21437:SF1 WIDE AWAKE WIDE AWAKE HELRO|EnsemblGenome=HelroG89106|UniProtKB=T1G787 T1G787 20216934 PTHR24637:SF377 COLLAGEN COLLAGEN TYPE IX ALPHA 1 CHAIN HELRO|EnsemblGenome=HelroG165697|UniProtKB=T1EX65 T1EX65 20201165 PTHR16172:SF41 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG99280|UniProtKB=T1G9R8 T1G9R8 20217814 PTHR44321:SF1 TRANSDUCIN BETA-LIKE PROTEIN 2 TRANSDUCIN BETA-LIKE PROTEIN 2 response to organic substance#GO:0010033;signal transduction#GO:0007165;endoplasmic reticulum unfolded protein response#GO:0030968;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;cellular response to chemical stimulus#GO:0070887;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to topologically incorrect protein#GO:0035967;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;response to topologically incorrect protein#GO:0035966;response to unfolded protein#GO:0006986;cellular response to unfolded protein#GO:0034620;biological regulation#GO:0065007;cellular response to stress#GO:0033554;signaling#GO:0023052 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG65955|UniProtKB=T1FYE9 T1FYE9 20213847 PTHR10625:SF36 HISTONE DEACETYLASE HDAC1-RELATED HISTONE DEACETYLASE 3 histone modifying activity#GO:0140993;histone deacetylase activity#GO:0004407;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;deacetylase activity#GO:0019213;catalytic activity, acting on a protein#GO:0140096 protein-DNA complex organization#GO:0071824;cellular component organization#GO:0016043;cellular process#GO:0009987;epigenetic regulation of gene expression#GO:0040029;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;protein-containing complex organization#GO:0043933;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 Wnt signaling pathway#P00057>Histone deacetylase#P01472 HELRO|EnsemblGenome=HelroG63009|UniProtKB=T1FX96 T1FX96 20213444 PTHR11850:SF329 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS HOMEOBOX PROTEIN CUP9-RELATED DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG178960|UniProtKB=T1FDZ0 T1FDZ0 20207039 PTHR43731:SF14 RHOMBOID PROTEASE PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185390|UniProtKB=T1FMR4 T1FMR4 20210113 PTHR11465:SF9 CATALASE CATALASE antioxidant activity#GO:0016209;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;tetrapyrrole binding#GO:0046906;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;oxidoreductase activity#GO:0016491;heme binding#GO:0020037 response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;response to oxygen-containing compound#GO:1901700;catabolic process#GO:0009056;cellular metabolic process#GO:0044237;response to reactive oxygen species#GO:0000302;response to oxidative stress#GO:0006979;cellular process#GO:0009987;cellular catabolic process#GO:0044248;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 peroxidase#PC00180;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG188686|UniProtKB=T1FQ92 T1FQ92 20210989 PTHR10877:SF183 POLYCYSTIN FAMILY MEMBER AT14535P-RELATED ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG158627|UniProtKB=T1EN13 T1EN13 20197963 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG84621|UniProtKB=T1G5L0 T1G5L0 20216357 PTHR24072:SF306 RHO FAMILY GTPASE RHO-RELATED GTP-BINDING PROTEIN RHOH GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;enzyme binding#GO:0019899;ribonucleoside triphosphate phosphatase activity#GO:0017111;kinase binding#GO:0019900;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817;heterocyclic compound binding#GO:1901363;protein kinase binding#GO:0019901;anion binding#GO:0043168;ion binding#GO:0043167 small GTPase#PC00208 Huntington disease#P00029>Rac#P00775;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Cdc42#P00834;FGF signaling pathway#P00021>Rac#P00645 HELRO|EnsemblGenome=HelroG97098|UniProtKB=T1G9F4 T1G9F4 20217701 PTHR11586:SF43 TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER TYROSINE--TRNA LIGASE, CYTOPLASMIC catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;ligase activity#GO:0016874;catalytic activity#GO:0003824 translational protein#PC00263 HELRO|EnsemblGenome=HelroG162115|UniProtKB=T1ES91 T1ES91 20199441 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG182196|UniProtKB=T1FHW8 T1FHW8 20208417 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG168336|UniProtKB=T1F0F9 T1F0F9 20202309 PTHR11731:SF200 PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED DIPEPTIDYL PEPTIDASE 10, ISOFORM B hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG73348|UniProtKB=T1G1C9 T1G1C9 20214877 PTHR18945:SF856 NEUROTRANSMITTER GATED ION CHANNEL GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA signaling receptor activity#GO:0038023;inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;molecular transducer activity#GO:0060089;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;transmembrane signaling receptor activity#GO:0004888 localization#GO:0051179;inorganic anion transmembrane transport#GO:0098661;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic anion transport#GO:0006820;chloride transport#GO:0006821;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;inorganic anion transport#GO:0015698 receptor complex#GO:0043235;protein-containing complex#GO:0032991 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG179807|UniProtKB=T1FF63 T1FF63 20207462 PTHR21284:SF12 EG:80H7.2 PROTEIN EG:80H7.2 PROTEIN HELRO|EnsemblGenome=HelroG75754|UniProtKB=T1G298 T1G298 20215196 PTHR24637:SF366 COLLAGEN NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164707|UniProtKB=T1EVR2 T1EVR2 20200662 PTHR20914:SF9 LY6/PLAUR DOMAIN-CONTAINING PROTEIN 8 COILED, ISOFORM A scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG193446|UniProtKB=T1FUZ8 T1FUZ8 20212644 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG75560|UniProtKB=T1G265 T1G265 20215163 PTHR24068:SF74 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2-17 KDA ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E2#P01491 HELRO|EnsemblGenome=HelroG168882|UniProtKB=T1F134 T1F134 20202534 PTHR11604:SF0 PROFILIN PROFILIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;actin binding#GO:0003779;binding#GO:0005488;actin monomer binding#GO:0003785 negative regulation of protein polymerization#GO:0032272;cellular localization#GO:0051641;negative regulation of biological process#GO:0048519;macromolecule localization#GO:0033036;regulation of cellular component organization#GO:0051128;regulation of actin polymerization or depolymerization#GO:0008064;regulation of biological process#GO:0050789;regulation of cytoskeleton organization#GO:0051493;regulation of protein-containing complex assembly#GO:0043254;regulation of biological quality#GO:0065008;regulation of cellular component biogenesis#GO:0044087;negative regulation of organelle organization#GO:0010639;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament-based process#GO:0032970;negative regulation of cellular component organization#GO:0051129;regulation of protein polymerization#GO:0032271;negative regulation of cellular process#GO:0048523;regulation of anatomical structure size#GO:0090066;regulation of actin filament length#GO:0030832;regulation of organelle organization#GO:0033043;regulation of actin filament organization#GO:0110053;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of actin filament polymerization#GO:0030833;regulation of cellular component size#GO:0032535;protein localization#GO:0008104;negative regulation of supramolecular fiber organization#GO:1902904;regulation of supramolecular fiber organization#GO:1902903;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;cellular macromolecule localization#GO:0070727;maintenance of location#GO:0051235;regulation of cellular process#GO:0050794;maintenance of location in cell#GO:0051651;negative regulation of actin filament polymerization#GO:0030837;biological regulation#GO:0065007;negative regulation of protein-containing complex assembly#GO:0031333;negative regulation of cytoskeleton organization#GO:0051494 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;cell cortex#GO:0005938;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 Cytoskeletal regulation by Rho GTPase#P00016>Profilin#P00521 HELRO|EnsemblGenome=HelroG122048|UniProtKB=T1EGT7 T1EGT7 20195787 PTHR11893:SF36 INNEXIN INNEXIN-5 cell junction protein#PC00070;gap junction#PC00105 HELRO|EnsemblGenome=HelroG101296|UniProtKB=Q25122 Q25122 cdc25 PTHR10828:SF76 M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25 M-PHASE INDUCER PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 regulation of cell cycle G2/M phase transition#GO:1902749;mitotic cell cycle phase transition#GO:0044772;regulation of mitotic cell cycle phase transition#GO:1901990;cell cycle process#GO:0022402;regulation of cell cycle phase transition#GO:1901987;positive regulation of cell cycle#GO:0045787;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047;cell cycle phase transition#GO:0044770;positive regulation of cellular process#GO:0048522;regulation of cell cycle process#GO:0010564;regulation of biological process#GO:0050789;G2/M transition of mitotic cell cycle#GO:0000086;mitotic cell cycle#GO:0000278;regulation of meiotic cell cycle#GO:0051445;regulation of cellular process#GO:0050794;positive regulation of cell cycle process#GO:0090068;positive regulation of mitotic cell cycle#GO:0045931;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of G2/M transition of mitotic cell cycle#GO:0010389;positive regulation of biological process#GO:0048518;regulation of mitotic cell cycle#GO:0007346;cell cycle G2/M phase transition#GO:0044839 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG85482|UniProtKB=T1G5X7 T1G5X7 20216474 PTHR24055:SF79 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE 15 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Integrin signalling pathway#P00034>ERK#P00907;EGF receptor signaling pathway#P00018>ERK1-2#P00543;Ras Pathway#P04393>ERK#P04542;Interleukin signaling pathway#P00036>ERK#P00965;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>MAPK#P00835;PDGF signaling pathway#P00047>ERK#P01143;FGF signaling pathway#P00021>ERK1-2#P00627;Interferon-gamma signaling pathway#P00035>Serine kinase#P00955;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;Toll receptor signaling pathway#P00054>ERK1#P01358;Apoptosis signaling pathway#P00006>MAPK#P00269;TGF-beta signaling pathway#P00052>p42/p44MAPKs#P01293;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>ERK#P00889;Parkinson disease#P00049>ERK#P01211;Endothelin signaling pathway#P00019>ERK#P00566 HELRO|EnsemblGenome=HelroG66732|UniProtKB=T1FYP9 T1FYP9 20213947 PTHR12290:SF19 CORNICHON-RELATED PROTEIN CORNICHON HOMOLOG 4 localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193 COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG178620|UniProtKB=T1FDG8 T1FDG8 20206867 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178471|UniProtKB=T1FD79 T1FD79 20206778 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG166414|UniProtKB=T1EY40 T1EY40 20201490 PTHR12197:SF251 HISTONE-LYSINE N-METHYLTRANSFERASE SMYD EG:BACR7C10.4 PROTEIN membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG160216|UniProtKB=T1EPZ7 T1EPZ7 20198647 PTHR47160:SF5 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77422|UniProtKB=T1G2X4 T1G2X4 20215422 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG158887|UniProtKB=T1END6 T1END6 20198086 PTHR12757:SF1 TUMOR NECROSIS FACTOR INDUCED PROTEIN PROTEIN SALIVARY GLANDS MARRED cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG94198|UniProtKB=T1G8Z3 T1G8Z3 20217540 PTHR10571:SF0 UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular anatomical entity#GO:0110165;membrane#GO:0016020 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG159592|UniProtKB=T1EP77 T1EP77 20198377 PTHR12758:SF19 APOPTOSIS INHIBITOR 5-RELATED APOPTOSIS INHIBITOR 5 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG190121|UniProtKB=T1FRP7 T1FRP7 20211494 PTHR24256:SF470 TRYPTASE-RELATED INACTIVE CLIP DOMAIN-CONTAINING SERINE PROTEASE A30 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG110736|UniProtKB=T1EF48 T1EF48 20195200 PTHR48012:SF2 STERILE20-LIKE KINASE, ISOFORM B-RELATED STERILE20-LIKE KINASE, ISOFORM B transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG173124|UniProtKB=T1F6E5 T1F6E5 20204394 PTHR14949:SF57 EGF-LIKE-DOMAIN, MULTIPLE 7, 8 EGF-LIKE DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 anatomical structure development#GO:0048856;developmental process#GO:0032502 cell surface#GO:0009986;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG191184|UniProtKB=T1FSQ0 T1FSQ0 20211847 PTHR42264:SF6 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE PROTEIN HELRO|EnsemblGenome=HelroG64765|UniProtKB=T1FXY7 T1FXY7 20213685 PTHR13054:SF2 DIGEORGE SYNDROME CRITICAL REGION 6 DGCR6 FAMILY MEMBER PROTEIN DGCR6 HELRO|EnsemblGenome=HelroG185281|UniProtKB=T1FML8 T1FML8 20210067 PTHR22739:SF7 STRIATED MUSCLE ACTIVATOR OF RHO-DEPENDENT SIGNALING-RELATED EG:152A3.3 PROTEIN-RELATED HELRO|EnsemblGenome=HelroG166859|UniProtKB=T1EYN3 T1EYN3 20201683 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG90460|UniProtKB=T1G7R7 T1G7R7 20217114 PTHR11847:SF4 RIBOSOMAL PROTEIN L15 LARGE RIBOSOMAL SUBUNIT PROTEIN EL15 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cytoplasmic translation#GO:0002181;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG169572|UniProtKB=T1F242 T1F242 20202892 PTHR19134:SF559 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE DOMAIN-CONTAINING PROTEIN hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG95831|UniProtKB=T1G980 T1G980 20217627 PTHR47633:SF4 IMMUNOGLOBULIN MYOPALLADIN ISOFORM X1 HELRO|EnsemblGenome=HelroG161249|UniProtKB=T1ER93 T1ER93 20199093 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191008|UniProtKB=T1FSH7 T1FSH7 20211774 PTHR19854:SF15 TRANSDUCIN BETA-LIKE 3 TRANSDUCIN BETA-LIKE PROTEIN 3 snoRNA binding#GO:0030515;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;ribosome biogenesis#GO:0042254;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981;90S preribosome#GO:0030686 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG102919|UniProtKB=T1EDD2 T1EDD2 20194584 PTHR14165:SF3 MAJOR VAULT PROTEIN MAJOR VAULT PROTEIN cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG89655|UniProtKB=T1G7F5 T1G7F5 20217002 PTHR10390:SF61 HOMEOBOX PROTEIN SIX HOMEOBOX PROTEIN SIX2 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG182211|UniProtKB=T1FHX7 T1FHX7 20208426 PTHR24241:SF76 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR NEUROPEPTIDE SIFAMIDE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;binding#GO:0005488;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888;amide binding#GO:0033218 response to organic substance#GO:0010033;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;response to hormone#GO:0009725;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG177414|UniProtKB=T1FBN2 T1FBN2 20206231 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED FMRFAMIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG177398|UniProtKB=T1FBM5 T1FBM5 20206224 PTHR22802:SF463 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG87910|UniProtKB=T1G6W6 T1G6W6 20216813 PTHR23506:SF26 GH10249P MFS-TYPE TRANSPORTER SLC18B1 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG163049|UniProtKB=T1ETL7 T1ETL7 20199917 PTHR15286:SF6 RAS-ASSOCIATING DOMAIN CONTAINING PROTEIN GH01133P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG110322|UniProtKB=T1EF14 T1EF14 20195166 PTHR24343:SF348 SERINE/THREONINE KINASE AT25266P transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG82658|UniProtKB=T1G4U9 T1G4U9 20216097 PTHR22984:SF25 SERINE/THREONINE-PROTEIN KINASE PIM PROTEIN KINASE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG190529|UniProtKB=T1FS27 T1FS27 20211624 PTHR15598:SF5 ENHANCER OF MRNA-DECAPPING PROTEIN 4 ENHANCER OF MRNA-DECAPPING PROTEIN 4 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;RNA decapping#GO:0110154;organic cyclic compound metabolic process#GO:1901360;mRNA catabolic process#GO:0006402;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;organic substance catabolic process#GO:1901575;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;nuclear-transcribed mRNA catabolic process#GO:0000956;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;P-body#GO:0000932;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031;mRNA capping factor#PC00145 HELRO|EnsemblGenome=HelroG187263|UniProtKB=T1FP84 T1FP84 20210631 PTHR10678:SF2 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 peptidase complex#GO:1905368;protein-containing complex#GO:0032991;proteasome accessory complex#GO:0022624;proteasome regulatory particle#GO:0005838;catalytic complex#GO:1902494;proteasome regulatory particle, lid subcomplex#GO:0008541;proteasome complex#GO:0000502;endopeptidase complex#GO:1905369;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489;Cell cycle#P00013>Proteasome#P00480 HELRO|EnsemblGenome=HelroG185826|UniProtKB=T1FNC2 T1FNC2 20210319 PTHR11240:SF22 RIBONUCLEASE T2 RIBONUCLEASE T2 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG76471|UniProtKB=T1G2K3 T1G2K3 20215301 PTHR24291:SF201 CYTOCHROME P450 FAMILY 4 CYTOCHROME P450, FAMILY 4, SUBFAMILY B, POLYPEPTIDE 7 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG65888|UniProtKB=T1FYE2 T1FYE2 20213840 PTHR10281:SF4 MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED NEUFERRICIN cellular anatomical entity#GO:0110165;membrane#GO:0016020;endomembrane system#GO:0012505 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG173209|UniProtKB=T1F6K6 T1F6K6 20204455 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG178766|UniProtKB=T1FDP5 T1FDP5 20206944 PTHR47827:SF3 AHD DOMAIN-CONTAINING PROTEIN AF-9 ANC1 HOMOLOGY DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;protein-containing complex binding#GO:0044877;histone binding#GO:0042393;binding#GO:0005488;chromatin binding#GO:0003682;modification-dependent protein binding#GO:0140030 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;transcription elongation factor complex#GO:0008023;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG187260|UniProtKB=T1FP83 T1FP83 20210630 PTHR14269:SF4 CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED CAT EYE SYNDROME CRITICAL REGION PROTEIN 5 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;glycerophospholipid metabolic process#GO:0006650;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;primary metabolic process#GO:0044238;glycerolipid metabolic process#GO:0046486;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG112973|UniProtKB=T1EFN8 T1EFN8 20195390 PTHR23280:SF34 4.1 G PROTEIN FERM DOMAIN CONTAINING 7 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;actomyosin structure organization#GO:0031032;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG188689|UniProtKB=T1FQ93 T1FQ93 20210990 PTHR10962:SF1 INTEGRAL TRANSMEMBRANE PROTEIN 2 INTEGRAL MEMBRANE PROTEIN 2 amyloid-beta binding#GO:0001540;binding#GO:0005488;amide binding#GO:0033218;peptide binding#GO:0042277 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of protein metabolic process#GO:0051246;negative regulation of biosynthetic process#GO:0009890;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;extracellular region#GO:0005576;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;extracellular space#GO:0005615;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185717|UniProtKB=T1FN69 T1FN69 20210267 PTHR10031:SF0 ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL ATPASE PROTEIN 9 cellular aromatic compound metabolic process#GO:0006725;ribonucleoside triphosphate metabolic process#GO:0009199;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative metabolic process#GO:1901135;ATP biosynthetic process#GO:0006754;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;purine nucleoside triphosphate biosynthetic process#GO:0009145;heterocycle metabolic process#GO:0046483;purine ribonucleoside triphosphate metabolic process#GO:0009205;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;ribonucleoside triphosphate biosynthetic process#GO:0009201;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;proton motive force-driven ATP synthesis#GO:0015986;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;purine nucleoside triphosphate metabolic process#GO:0009144;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;proton-transporting two-sector ATPase complex, proton-transporting domain#GO:0033177;ATPase complex#GO:1904949;cellular anatomical entity#GO:0110165;membrane#GO:0016020;proton-transporting ATP synthase complex#GO:0045259;proton-transporting ATP synthase complex, coupling factor F(o)#GO:0045263;proton-transporting two-sector ATPase complex#GO:0016469;intracellular anatomical structure#GO:0005622 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG180236|UniProtKB=T1FFL7 T1FFL7 20207616 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG68094|UniProtKB=T1FZA1 T1FZA1 20214149 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;chloride transmembrane transporter activity#GO:0015108;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;inorganic anion transmembrane transport#GO:0098661;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic anion transport#GO:0006820;chloride transport#GO:0006821;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;inorganic anion transport#GO:0015698 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG135381|UniProtKB=T1EI85 T1EI85 20196285 PTHR12300:SF117 HVA22-LIKE PROTEINS LP05237P-RELATED membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG129809|UniProtKB=T1EHS3 T1EHS3 20196123 PTHR24240:SF85 OPSIN OPSIN RH1-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;response to light stimulus#GO:0009416;cellular response to stimulus#GO:0051716;detection of stimulus#GO:0051606;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to external stimulus#GO:0009605;regulation of cellular process#GO:0050794;response to radiation#GO:0009314;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;response to abiotic stimulus#GO:0009628;signaling#GO:0023052;cellular response to light stimulus#GO:0071482 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Rhodopsin#P00747 HELRO|EnsemblGenome=HelroG172521|UniProtKB=T1F5G3 T1F5G3 20204062 PTHR16021:SF27 MANSC DOMAIN CONTAINING PROTEIN 1 EARTHBOUND 1 HELRO|EnsemblGenome=HelroG124648|UniProtKB=T1EH22 T1EH22 20195872 PTHR24070:SF290 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY RAS-LIKE, FAMILY 10, MEMBER A GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG110840|UniProtKB=T1EF56 T1EF56 20195208 PTHR11607:SF3 ALPHA-MANNOSIDASE LYSOSOMAL ALPHA-MANNOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 glycosidase#PC00110;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG159230|UniProtKB=T1ENS0 T1ENS0 20198220 PTHR15272:SF0 CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;nucleosome organization#GO:0034728;nucleosome assembly#GO:0006334;protein-containing complex organization#GO:0043933;protein-containing complex assembly#GO:0065003;chromatin organization#GO:0006325;cellular component organization#GO:0016043;cellular process#GO:0009987;chromatin remodeling#GO:0006338;protein-DNA complex assembly#GO:0065004 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG66358|UniProtKB=T1FYK1 T1FYK1 20213899 PTHR11771:SF153 LIPOXYGENASE LIPOXYGENASE DOMAIN-CONTAINING PROTEIN oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;dioxygenase activity#GO:0051213 lipid metabolic process#GO:0006629;lipid oxidation#GO:0034440;cellular metabolic process#GO:0044237;lipid modification#GO:0030258;cellular lipid metabolic process#GO:0044255;cellular process#GO:0009987;metabolic process#GO:0008152;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG79677|UniProtKB=T1G3S1 T1G3S1 20215719 PTHR34839:SF1 CS DOMAIN-CONTAINING PROTEIN MYOSIN-9-LIKE HELRO|EnsemblGenome=HelroG178719|UniProtKB=T1FDM5 T1FDM5 20206924 PTHR46169:SF27 DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A SI:DKEY-13N23.3-RELATED regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG185901|UniProtKB=T1FNF1 T1FNF1 20210348 PTHR11005:SF161 LYSOSOMAL ACID LIPASE-RELATED LIPASE lipase#PC00143;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG191983|UniProtKB=T1FTH5 T1FTH5 20212122 PTHR15138:SF14 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4 nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;transcription initiation at RNA polymerase II promoter#GO:0006367;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nucleobase-containing compound biosynthetic process#GO:0034654;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;transcription factor TFIID complex#GO:0005669;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase II, holoenzyme#GO:0016591;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;general transcription factor#PC00259 General transcription regulation#P00023>TBP-associated factors#P00658;Huntington disease#P00029>TAFII130#P00806;Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385 HELRO|EnsemblGenome=HelroG191993|UniProtKB=T1FTH7 T1FTH7 20212124 PTHR23085:SF16 GH28348P GH28348P intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG182613|UniProtKB=T1FIH3 T1FIH3 20208622 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG86051|UniProtKB=T1G667 T1G667 20216564 PTHR10682:SF10 POLY A POLYMERASE POLYNUCLEOTIDE ADENYLYLTRANSFERASE adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;mRNA polyadenylation#GO:0006378;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;mRNA 3'-end processing#GO:0031124;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mRNA processing#GO:0006397;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG89616|UniProtKB=T1G7F0 T1G7F0 20216997 PTHR10920:SF18 RIBOSOMAL RNA METHYLTRANSFERASE RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL catalytic activity, acting on RNA#GO:0140098;transferase activity#GO:0016740;O-methyltransferase activity#GO:0008171;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on a rRNA#GO:0140102;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;rRNA methyltransferase activity#GO:0008649;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;RNA methyltransferase activity#GO:0008173 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;methylation#GO:0032259;macromolecule methylation#GO:0043414;nitrogen compound metabolic process#GO:0006807;RNA methylation#GO:0001510;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG172705|UniProtKB=T1F5T8 T1F5T8 20204187 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG78950|UniProtKB=T1G3H6 T1G3H6 20215624 PTHR23105:SF54 RIBOSOMAL PROTEIN L7AE FAMILY MEMBER H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 2 snoRNA binding#GO:0030515;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA modification#GO:0009451;rRNA modification#GO:0000154;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;ribosome biogenesis#GO:0042254;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;snRNA metabolic process#GO:0016073;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;pseudouridine synthesis#GO:0001522;nucleic acid metabolic process#GO:0090304;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG174247|UniProtKB=T1F7V6 T1F7V6 20204905 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG98767|UniProtKB=T1G9P6 T1G9P6 20217792 PTHR45646:SF11 SERINE/THREONINE-PROTEIN KINASE DOA-RELATED SERINE_THREONINE-PROTEIN KINASE DOA transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191119|UniProtKB=T1FSM0 T1FSM0 20211817 PTHR14948:SF25 NG5 DUF4190 DOMAIN-CONTAINING PROTEIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG191453|UniProtKB=T1FT01 T1FT01 20211948 PTHR15137:SF9 TRANSCRIPTION INITIATION FACTOR TFIID TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;chromatin binding#GO:0003682;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;protein-containing complex binding#GO:0044877 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;DNA-templated transcription#GO:0006351;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;transcription initiation at RNA polymerase II promoter#GO:0006367;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;DNA-directed RNA polymerase complex#GO:0000428;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nucleoplasm#GO:0005654;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;transcription factor TFIID complex#GO:0005669;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;transcription regulator complex#GO:0005667;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 general transcription factor#PC00259 General transcription regulation#P00023>TBP-associated factors#P00658;Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385 HELRO|EnsemblGenome=HelroG186141|UniProtKB=T1FNQ2 T1FNQ2 20210449 PTHR13130:SF4 34 KDA TRANSCRIPTIONAL CO-ACTIVATOR-RELATED MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 27 transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG192743|UniProtKB=T1FU92 T1FU92 20212388 PTHR11958:SF99 SODIUM/DICARBOXYLATE SYMPORTER-RELATED SODIUM-DEPENDENT EXCITATORY AMINO ACID TRANSPORTER GLT-6-RELATED inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;organic acid:sodium symporter activity#GO:0005343;organic acid transmembrane transporter activity#GO:0005342;symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;L-amino acid transmembrane transporter activity#GO:0015179;organic anion transmembrane transporter activity#GO:0008514;monoatomic cation transmembrane transporter activity#GO:0008324;acidic amino acid transmembrane transporter activity#GO:0015172;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;amino acid:sodium symporter activity#GO:0005283;secondary active transmembrane transporter activity#GO:0015291;L-glutamate transmembrane transporter activity#GO:0005313;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;amino acid transmembrane transporter activity#GO:0015171;inorganic cation transmembrane transporter activity#GO:0022890;neutral L-amino acid transmembrane transporter activity#GO:0015175;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 L-amino acid transport#GO:0015807;transmembrane transport#GO:0055085;dicarboxylic acid transport#GO:0006835;organic anion transport#GO:0015711;acidic amino acid transport#GO:0015800;amino acid transport#GO:0006865;organic acid transport#GO:0015849;transport#GO:0006810;nitrogen compound transport#GO:0071705;carboxylic acid transport#GO:0046942;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039;localization#GO:0051179;organic substance transport#GO:0071702;amino acid transmembrane transport#GO:0003333;establishment of localization#GO:0051234;L-alpha-amino acid transmembrane transport#GO:1902475;organic acid transmembrane transport#GO:1903825 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG176731|UniProtKB=T1FAU6 T1FAU6 20205945 PTHR12346:SF0 SIN3B-RELATED SIN3A, ISOFORM G molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;protein-macromolecule adaptor activity#GO:0030674 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;histone deacetylase complex#GO:0000118;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077 Huntington disease#P00029>Sin3A#P00771 HELRO|EnsemblGenome=HelroG110863|UniProtKB=T1EF58 T1EF58 20195210 PTHR11133:SF22 SACCHAROPINE DEHYDROGENASE ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG165459|UniProtKB=T1EWU2 T1EWU2 20201042 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182019|UniProtKB=T1FHL8 T1FHL8 20208317 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG88263|UniProtKB=T1G710 T1G710 20216857 PTHR33963:SF2 MKRN2 OPPOSITE STRAND PROTEIN MKRN2 OPPOSITE STRAND PROTEIN HELRO|EnsemblGenome=HelroG68360|UniProtKB=T1FZD7 T1FZD7 20214185 PTHR19134:SF536 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE DOMAIN-CONTAINING PROTEIN hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG176573|UniProtKB=T1FAN9 T1FAN9 20205888 PTHR35258:SF1 SPERMATOGENESIS-ASSOCIATED PROTEIN 22 SPERMATOGENESIS-ASSOCIATED PROTEIN 22 biological regulation#GO:0065007;regulation of biological process#GO:0050789;regulation of cell cycle#GO:0051726;regulation of meiotic cell cycle#GO:0051445;regulation of cellular process#GO:0050794 HELRO|EnsemblGenome=HelroG174683|UniProtKB=T1F8D3 T1F8D3 20205082 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG163137|UniProtKB=T1ETP8 T1ETP8 20199948 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG153251|UniProtKB=T1EL17 T1EL17 20197267 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG115195|UniProtKB=T1EG71 T1EG71 20195573 PTHR11085:SF1 NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-7 nucleotide binding#GO:0000166;histone modifying activity#GO:0140993;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;deacetylase activity#GO:0019213;histone deacetylase activity#GO:0004407;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168;catalytic activity, acting on a protein#GO:0140096 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG83426|UniProtKB=T1G553 T1G553 20216201 PTHR24333:SF5 HOMEO BOX HB9 LIKE A-RELATED VENT HOMEOBOX homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG77327|UniProtKB=T1G2W2 T1G2W2 20215410 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG162360|UniProtKB=T1ESK1 T1ESK1 20199551 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161400|UniProtKB=T1ERF9 T1ERF9 20199159 PTHR21389:SF0 P53 INDUCED PROTEIN ETOPOSIDE-INDUCED PROTEIN 2.4 HOMOLOG process utilizing autophagic mechanism#GO:0061919;macroautophagy#GO:0016236;cellular metabolic process#GO:0044237;catabolic process#GO:0009056;cellular process#GO:0009987;autophagy#GO:0006914;metabolic process#GO:0008152;cellular catabolic process#GO:0044248 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG77767|UniProtKB=T1G336 T1G336 20215484 PTHR23064:SF72 TROPONIN TROPONIN C, SKELETAL MUSCLE cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG160849|UniProtKB=T1EQT7 T1EQT7 20198937 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG170840|UniProtKB=T1F3I0 T1F3I0 20203379 PTHR13155:SF1 A-KINASE ANCHOR PROTEINS A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG174781|UniProtKB=T1F8G8 T1F8G8 20205117 PTHR46760:SF1 TRANSCRIPTION TERMINATION FACTOR 1 TRANSCRIPTION TERMINATION FACTOR 1 General transcription by RNA polymerase I#P00022>TTF-I#P00654;General transcription regulation#P00023>TTF2#P00661;Transcription regulation by bZIP transcription factor#P00055>TTF2#P01389 HELRO|EnsemblGenome=HelroG78883|UniProtKB=T1G3G8 T1G3G8 20215616 PTHR14091:SF0 PERIODIC TRYPTOPHAN PROTEIN 1 PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG180341|UniProtKB=T1FFS3 T1FFS3 20207672 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG193671|UniProtKB=T1FV89 T1FV89 20212735 PTHR11003:SF334 POTASSIUM CHANNEL, SUBFAMILY K FI03418P monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG165064|UniProtKB=T1EW86 T1EW86 20200836 PTHR46513:SF13 VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG89499|UniProtKB=T1G7D8 T1G7D8 20216985 PTHR11636:SF70 POU DOMAIN INHIBITORY POU PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG171628|UniProtKB=T1F4H3 T1F4H3 20203722 PTHR21646:SF23 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE USP2 cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG183216|UniProtKB=T1FJB7 T1FJB7 20208916 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG177721|UniProtKB=T1FC46 T1FC46 20206395 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG139909|UniProtKB=T1EIZ5 T1EIZ5 20196545 PTHR12064:SF94 METAL TRANSPORTER CNNM UNEXTENDED PROTEIN ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG90981|UniProtKB=T1G7Y2 T1G7Y2 20217179 PTHR24089:SF57 SOLUTE CARRIER FAMILY 25 FI05451P carbohydrate derivative transmembrane transporter activity#GO:1901505;purine nucleotide transmembrane transporter activity#GO:0015216;nucleobase-containing compound transmembrane transporter activity#GO:0015932;transmembrane transporter activity#GO:0022857;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215 localization#GO:0051179;organic substance transport#GO:0071702;organophosphate ester transport#GO:0015748;establishment of localization#GO:0051234;organic anion transport#GO:0015711;nucleobase-containing compound transport#GO:0015931;transport#GO:0006810;nitrogen compound transport#GO:0071705;carbohydrate derivative transport#GO:1901264 mitochondrial carrier protein#PC00158;secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG94509|UniProtKB=T1G914 T1G914 20217561 PTHR42735:SF1 FAMILY NOT NAMED PYRIDOXAL-DEPENDENT DECARBOXYLASE DOMAIN-CONTAINING PROTEIN 1-RELATED lyase activity#GO:0016829;carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;lipid catabolic process#GO:0016042;cellular process#GO:0009987;sphingolipid metabolic process#GO:0006665;primary metabolic process#GO:0044238;membrane lipid metabolic process#GO:0006643;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;sphingolipid catabolic process#GO:0030149;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG191441|UniProtKB=T1FSZ7 T1FSZ7 20211944 PTHR46621:SF1 SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4 SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;RNA metabolic process#GO:0016070;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;heterocycle metabolic process#GO:0046483;snRNA metabolic process#GO:0016073;transcription by RNA polymerase III#GO:0006383;snRNA transcription by RNA polymerase II#GO:0042795;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;ncRNA transcription#GO:0098781;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667 HELRO|EnsemblGenome=HelroG186240|UniProtKB=T1FNV0 T1FNV0 20210497 PTHR18952:SF141 CARBONIC ANHYDRASE CARBONIC ANHYDRASE carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG173125|UniProtKB=T1F6E6 T1F6E6 20204395 PTHR33332:SF48 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169603|UniProtKB=T1F257 T1F257 20202907 PTHR18763:SF0 WD-REPEAT PROTEIN 18 WD REPEAT-CONTAINING PROTEIN 18 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;DNA-templated DNA replication#GO:0006261;ribosome biogenesis#GO:0042254;DNA replication#GO:0006260;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;metabolic process#GO:0008152 membrane-enclosed lumen#GO:0031974;pre-replicative complex#GO:0036387;organelle lumen#GO:0043233;endoribonuclease complex#GO:1902555;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;endonuclease complex#GO:1905348;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;nuclear pre-replicative complex#GO:0005656;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG70596|UniProtKB=T1G091 T1G091 20214489 PTHR46095:SF1 ZINC FINGER PROTEIN 593 ZINC FINGER PROTEIN 593 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG105422|UniProtKB=T1EDU7 T1EDU7 20194749 PTHR11905:SF159 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG189836|UniProtKB=T1FRE7 T1FRE7 20211394 PTHR13371:SF0 GLYCINE-, GLUTAMATE-, THIENYLCYCLOHEXYLPIPERIDINE-BINDING PROTEIN CENTROSOMAL PROTEIN OF 104 KDA membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cilium#GO:0005929;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025 HELRO|EnsemblGenome=HelroG156909|UniProtKB=T1EM29 T1EM29 20197629 PTHR11267:SF199 T-BOX PROTEIN-RELATED T-BOX PROTEIN 36-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cell fate commitment#GO:0045165;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;cell fate specification#GO:0001708;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HELRO|EnsemblGenome=HelroG69922|UniProtKB=T1FZZ7 T1FZZ7 20214395 PTHR11675:SF131 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 9-RELATED transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG194359|UniProtKB=T1FVZ4 T1FVZ4 20212990 PTHR19918:SF1 CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED FIZZY-RELATED PROTEIN HOMOLOG protein-containing complex binding#GO:0044877;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;binding#GO:0005488 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of protein metabolic process#GO:0051246;regulation of catabolic process#GO:0009894;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of proteasomal protein catabolic process#GO:1901800;protein catabolic process#GO:0030163;organonitrogen compound catabolic process#GO:1901565;regulation of protein catabolic process#GO:0042176;regulation of proteolysis involved in protein catabolic process#GO:1903050;positive regulation of proteolysis#GO:0045862;modification-dependent macromolecule catabolic process#GO:0043632;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;positive regulation of biological process#GO:0048518;proteolysis involved in protein catabolic process#GO:0051603;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;regulation of proteolysis#GO:0030162;macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;positive regulation of proteolysis involved in protein catabolic process#GO:1903052;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;organonitrogen compound metabolic process#GO:1901564;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of proteasomal protein catabolic process#GO:0061136;regulation of primary metabolic process#GO:0080090;positive regulation of protein metabolic process#GO:0051247;anaphase-promoting complex-dependent catabolic process#GO:0031145;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;positive regulation of catabolic process#GO:0009896;positive regulation of protein catabolic process#GO:0045732;regulation of metabolic process#GO:0019222;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434 ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234;anaphase-promoting complex#GO:0005680;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG64141|UniProtKB=T1FXQ2 T1FXQ2 20213600 PTHR23291:SF47 BAX INHIBITOR-RELATED TRANSMEMBRANE BAX INHIBITOR MOTIF CONTAINING 7 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG88075|UniProtKB=T1G6Y2 T1G6Y2 20216829 PTHR21181:SF7 FAMILY NOT NAMED ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5 inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;inorganic cation transmembrane transporter activity#GO:0022890 membrane protein complex#GO:0098796;endosome#GO:0005768;endoplasmic reticulum protein-containing complex#GO:0140534;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;early endosome#GO:0005769;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;EMC complex#GO:0072546;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG77267|UniProtKB=T1G2V4 T1G2V4 20216672 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG73887|UniProtKB=T1G1K3 T1G1K3 20214951 PTHR23252:SF24 INTIMAL THICKNESS RECEPTOR-RELATED TRANSMEMBRANE PROTEIN 145 HELRO|EnsemblGenome=HelroG190751|UniProtKB=T1FS95 T1FS95 20211692 PTHR11523:SF28 SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT NA_K-ATPASE BETA SUBUNIT ISOFORM 4-RELATED molecular function activator activity#GO:0140677;ATPase activator activity#GO:0001671;molecular function regulator activity#GO:0098772 inorganic ion homeostasis#GO:0098771;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;sodium ion homeostasis#GO:0055078;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;import into cell#GO:0098657;monoatomic cation transmembrane transport#GO:0098655;export from cell#GO:0140352;sodium ion transmembrane transport#GO:0035725;potassium ion import across plasma membrane#GO:1990573;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG166976|UniProtKB=T1EYU2 T1EYU2 20201742 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG76552|UniProtKB=T1G2L4 T1G2L4 20215312 PTHR24346:SF49 MAP/MICROTUBULE AFFINITY-REGULATING KINASE NIM1 SERINE_THREONINE PROTEIN KINASE transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;microtubule cytoskeleton organization#GO:0000226;cell communication#GO:0007154;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;regulation of cellular process#GO:0050794;organelle organization#GO:0006996;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;intracellular signal transduction#GO:0035556;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG115837|UniProtKB=T1EGB2 T1EGB2 20195614 PTHR12247:SF132 POLYCOMB GROUP PROTEIN POLYCOMB PROTEIN SCM protein binding#GO:0005515;protein-containing complex binding#GO:0044877;histone binding#GO:0042393;binding#GO:0005488;chromatin binding#GO:0003682 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG116595|UniProtKB=T1EGG3 T1EGG3 20195665 PTHR12280:SF30 PANTOTHENATE KINASE FUMBLE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 kinase#PC00137 Coenzyme A biosynthesis#P02736>Pantothenate kinase#P02885 HELRO|EnsemblGenome=HelroG185264|UniProtKB=T1FMK9 T1FMK9 20210058 PTHR45850:SF1 SORTING NEXIN FAMILY MEMBER SORTING NEXIN 6, ISOFORM B scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG87437|UniProtKB=T1G6Q0 T1G6Q0 20216747 PTHR24322:SF736 PKSB RETINOL DEHYDROGENASE 10 oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG187461|UniProtKB=T1FPA0 T1FPA0 20210647 PTHR11909:SF428 CASEIN KINASE-RELATED CASEIN KINASE I ISOFORM EPSILON transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of protein metabolic process#GO:0051246;regulation of catabolic process#GO:0009894;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of signal transduction#GO:0009967;regulation of proteolysis involved in protein catabolic process#GO:1903050;positive regulation of proteolysis#GO:0045862;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;regulation of signal transduction#GO:0009966;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;positive regulation of proteolysis involved in protein catabolic process#GO:1903052;macromolecule metabolic process#GO:0043170;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cellular metabolic process#GO:0044237;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;cell communication#GO:0007154;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;positive regulation of canonical Wnt signaling pathway#GO:0090263;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of catabolic process#GO:0009896;positive regulation of protein catabolic process#GO:0045732;import into cell#GO:0098657;regulation of metabolic process#GO:0019222;positive regulation of nitrogen compound metabolic process#GO:0051173;signal transduction#GO:0007165;macromolecule modification#GO:0043412;regulation of signaling#GO:0023051;transport#GO:0006810;positive regulation of proteasomal protein catabolic process#GO:1901800;protein modification process#GO:0036211;regulation of protein catabolic process#GO:0042176;peptidyl-amino acid modification#GO:0018193;positive regulation of Wnt signaling pathway#GO:0030177;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;positive regulation of response to stimulus#GO:0048584;positive regulation of metabolic process#GO:0009893;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;signaling#GO:0023052;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;metabolic process#GO:0008152;regulation of cell communication#GO:0010646;regulation of proteolysis#GO:0030162;cellular response to stimulus#GO:0051716;organonitrogen compound metabolic process#GO:1901564;protein phosphorylation#GO:0006468;cellular process#GO:0009987;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of proteasomal protein catabolic process#GO:0061136;regulation of primary metabolic process#GO:0080090;localization#GO:0051179;response to stimulus#GO:0050896;positive regulation of protein metabolic process#GO:0051247;regulation of macromolecule metabolic process#GO:0060255;regulation of Wnt signaling pathway#GO:0030111;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;CCKR signaling map#P06959>CK1delta/epsilon#P07089;Hedgehog signaling pathway#P00025>Casein kinase I#P00681;Circadian clock system#P00015>Casein kinase I#P00502;Parkinson disease#P00049>Casein kinase I#P01242 HELRO|EnsemblGenome=HelroG178816|UniProtKB=T1FDS4 T1FDS4 20206973 PTHR11461:SF372 SERINE PROTEASE INHIBITOR, SERPIN ACCESSORY GLAND PROTEIN ACP76A-RELATED extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG91638|UniProtKB=T1G869 T1G869 20217266 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG147055|UniProtKB=T1EJW5 T1EJW5 20196865 PTHR10071:SF281 TRANSCRIPTION FACTOR GATA FAMILY MEMBER BOX A-BINDING FACTOR-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of RNA metabolic process#GO:0051253;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of transcription by RNA polymerase II#GO:0000122;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;regulation of DNA-templated transcription#GO:0006355;negative regulation of metabolic process#GO:0009892;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;negative regulation of nitrogen compound metabolic process#GO:0051172;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG71774|UniProtKB=T1G0R5 T1G0R5 20214663 PTHR24083:SF98 NUCLEAR HORMONE RECEPTOR NUCLEAR RECEPTOR SUBFAMILY 2 GROUP E MEMBER 1 cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;signaling receptor activity#GO:0038023;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG110129|UniProtKB=T1EEZ6 T1EEZ6 20195148 PTHR11409:SF42 ADENOSINE DEAMINASE ADENOSINE DEAMINASE-LIKE PROTEIN hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;adenosine deaminase activity#GO:0004000;deaminase activity#GO:0019239;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;nucleoside metabolic process#GO:0009116;glycosyl compound catabolic process#GO:1901658;carbohydrate derivative metabolic process#GO:1901135;heterocycle catabolic process#GO:0046700;organonitrogen compound catabolic process#GO:1901565;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase metabolic process#GO:0009112;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;purine-containing compound catabolic process#GO:0072523;organic cyclic compound metabolic process#GO:1901360;purine nucleoside metabolic process#GO:0042278;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;purine-containing compound metabolic process#GO:0072521;catabolic process#GO:0009056;nucleoside catabolic process#GO:0009164;organic substance catabolic process#GO:1901575;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;carbohydrate derivative catabolic process#GO:1901136;purine nucleobase metabolic process#GO:0006144;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;purine nucleoside catabolic process#GO:0006152;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;aromatic compound catabolic process#GO:0019439;nucleobase-containing compound biosynthetic process#GO:0034654;small molecule catabolic process#GO:0044282;nucleobase-containing small molecule catabolic process#GO:0034656;adenosine metabolic process#GO:0046085;organic cyclic compound catabolic process#GO:1901361;aromatic compound biosynthetic process#GO:0019438;small molecule biosynthetic process#GO:0044283;nucleobase-containing compound catabolic process#GO:0034655;glycosyl compound metabolic process#GO:1901657;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 deaminase#PC00088;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 Adenine and hypoxanthine salvage pathway#P02723>Adenosine deaminase#P02811;Adenine and hypoxanthine salvage pathway#P02723>Deoxyadenosine deaminase#P02807 HELRO|EnsemblGenome=HelroG174391|UniProtKB=T1F829 T1F829 20204978 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188697|UniProtKB=T1FQ97 T1FQ97 20210994 PTHR10188:SF8 L-ASPARAGINASE THREONINE ASPARTASE 1 hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG186157|UniProtKB=T1FNQ9 T1FNQ9 20210456 PTHR10177:SF347 CYCLINS G2_MITOTIC-SPECIFIC CYCLIN-B3 protein kinase regulator activity#GO:0019887;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 regulation of protein kinase activity#GO:0045859;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;mitotic cell cycle phase transition#GO:0044772;regulation of nitrogen compound metabolic process#GO:0051171;cell cycle process#GO:0022402;regulation of catalytic activity#GO:0050790;cellular process#GO:0009987;cell cycle phase transition#GO:0044770;mitotic cell cycle process#GO:1903047;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;regulation of primary metabolic process#GO:0080090;mitotic cell cycle#GO:0000278;regulation of macromolecule metabolic process#GO:0060255;regulation of molecular function#GO:0065009;regulation of protein phosphorylation#GO:0001932;regulation of cellular process#GO:0050794;regulation of protein serine/threonine kinase activity#GO:0071900;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cyclin-dependent protein serine/threonine kinase activity#GO:0000079;regulation of kinase activity#GO:0043549;regulation of cellular metabolic process#GO:0031323 microtubule organizing center#GO:0005815;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;centrosome#GO:0005813;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856 kinase activator#PC00138 Cell cycle#P00013>Cyclin B#P00486;p53 pathway#P00059>Cyclin B#P04614 HELRO|EnsemblGenome=HelroG162309|UniProtKB=T1ESH8 T1ESH8 20199528 PTHR12109:SF3 RING FINGER PROTEIN 141-RELATED RING FINGER PROTEIN 141 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG193969|UniProtKB=T1FVI7 T1FVI7 20212833 PTHR23382:SF3 MALATE DEHYDROGENASE MALATE DEHYDROGENASE, CYTOPLASMIC oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 cellular aromatic compound metabolic process#GO:0006725;dicarboxylic acid metabolic process#GO:0043648;pyridine nucleotide metabolic process#GO:0019362;nucleobase-containing compound metabolic process#GO:0006139;energy derivation by oxidation of organic compounds#GO:0015980;phosphorus metabolic process#GO:0006793;tricarboxylic acid cycle#GO:0006099;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;oxoacid metabolic process#GO:0043436;generation of precursor metabolites and energy#GO:0006091;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;nicotinamide nucleotide metabolic process#GO:0046496;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;carboxylic acid metabolic process#GO:0019752;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 dehydrogenase#PC00092;oxidoreductase#PC00176 TCA cycle#P00051>Malate Dehydrogenase#P01270 HELRO|EnsemblGenome=HelroG194032|UniProtKB=T1FVL3 T1FVL3 20212859 PTHR12942:SF2 STEP II SPLICING FACTOR SLU7 PRE-MRNA-SPLICING FACTOR SLU7 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG105393|UniProtKB=T1EDU4 T1EDU4 20194746 PTHR21713:SF4 NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED GH09281P-RELATED protein binding#GO:0005515;unfolded protein binding#GO:0051082;binding#GO:0005488 localization#GO:0051179;establishment of protein localization to membrane#GO:0090150;localization within membrane#GO:0051668;protein targeting to membrane#GO:0006612;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;protein localization to membrane#GO:0072657;protein targeting#GO:0006605;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG63220|UniProtKB=T1FXC6 T1FXC6 20213474 PTHR21094:SF2 GOS-28 SNARE- RELATED GOLGI SNAP RECEPTOR COMPLEX MEMBER 1 molecular adaptor activity#GO:0060090;SNAP receptor activity#GO:0005484;protein-macromolecule adaptor activity#GO:0030674 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;vesicle fusion#GO:0006906;cellular localization#GO:0051641;intra-Golgi vesicle-mediated transport#GO:0006891;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;membrane fusion#GO:0061025;establishment of localization#GO:0051234;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;vesicle organization#GO:0016050;intracellular transport#GO:0046907;organelle fusion#GO:0048284 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;Golgi cisterna#GO:0031985;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;SNARE complex#GO:0031201;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;Golgi stack#GO:0005795;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791;Golgi membrane#GO:0000139 SNARE protein#PC00034 HELRO|EnsemblGenome=HelroG194606|UniProtKB=T1FW86 T1FW86 20213082 PTHR24408:SF58 ZINC FINGER PROTEIN TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG163628|UniProtKB=T1EUA6 T1EUA6 20200156 PTHR10732:SF0 40S RIBOSOMAL PROTEIN S17 40S RIBOSOMAL PROTEIN S17 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG177783|UniProtKB=T1FC93 T1FC93 20206442 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG190268|UniProtKB=T1FRU3 T1FRU3 20211540 PTHR23421:SF165 BETA-GALACTOSIDASE RELATED BETA-GALACTOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 galactosidase#PC00104;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG157296|UniProtKB=T1EM89 T1EM89 20197689 PTHR13774:SF17 PHENAZINE BIOSYNTHESIS PROTEIN PHENAZINE BIOSYNTHESIS-LIKE DOMAIN-CONTAINING PROTEIN isomerase activity#GO:0016853;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG91322|UniProtKB=T1G826 T1G826 20217223 PTHR47464:SF2 MACOILIN MACOILIN HELRO|EnsemblGenome=HelroG154266|UniProtKB=T1ELE3 T1ELE3 20197393 PTHR10494:SF6 BONE MORPHOGENETIC PROTEIN INHIBITOR, NOGGIN NOGGIN regulation of cell communication#GO:0010646;cellular developmental process#GO:0048869;negative regulation of biological process#GO:0048519;negative regulation of response to stimulus#GO:0048585;ossification#GO:0001503;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;developmental process#GO:0032502;osteoblast differentiation#GO:0001649;cellular process#GO:0009987;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of BMP signaling pathway#GO:0030510;cell differentiation#GO:0030154;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;negative regulation of BMP signaling pathway#GO:0030514;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cellular response to growth factor stimulus#GO:0090287;negative regulation of signal transduction#GO:0009968;multicellular organismal process#GO:0032501;negative regulation of cell communication#GO:0010648;negative regulation of cellular process#GO:0048523 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG64016|UniProtKB=T1FXN4 T1FXN4 20213582 PTHR22880:SF225 FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED protein binding#GO:0005515;histone binding#GO:0042393;binding#GO:0005488;modification-dependent protein binding#GO:0140030 protein-DNA complex organization#GO:0071824;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;cellular component organization#GO:0016043;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG168227|UniProtKB=T1F0C1 T1F0C1 20202271 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174718|UniProtKB=T1F8E5 T1F8E5 20205094 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183251|UniProtKB=T1FJD5 T1FJD5 20208934 PTHR23320:SF163 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN transporter#PC00227 HELRO|EnsemblGenome=HelroG74696|UniProtKB=T1G1U5 T1G1U5 20215043 PTHR11616:SF320 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM-DEPENDENT NORADRENALINE TRANSPORTER metal ion transport#GO:0030001;transmembrane transport#GO:0055085;amino acid transport#GO:0006865;organic anion transport#GO:0015711;organic acid transport#GO:0015849;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;nitrogen compound transport#GO:0071705;carboxylic acid transport#GO:0046942;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;organic substance transport#GO:0071702;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 Adrenaline and noradrenaline biosynthesis#P00001>NET#P00064 HELRO|EnsemblGenome=HelroG90303|UniProtKB=T1G7P0 T1G7P0 20217087 PTHR10856:SF44 CORONIN CORONIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG175100|UniProtKB=T1F8U7 T1F8U7 20205246 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG88114|UniProtKB=T1G6Y7 T1G6Y7 20216834 PTHR12400:SF26 INOSITOL POLYPHOSPHATE KINASE KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;phosphotransferase activity, phosphate group as acceptor#GO:0016776 organic hydroxy compound metabolic process#GO:1901615;lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycerolipid biosynthetic process#GO:0045017;alcohol biosynthetic process#GO:0046165;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic hydroxy compound biosynthetic process#GO:1901617;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;alcohol metabolic process#GO:0006066;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;small molecule biosynthetic process#GO:0044283;cellular lipid metabolic process#GO:0044255;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 kinase#PC00137 HELRO|EnsemblGenome=HelroG154625|UniProtKB=T1ELF3 T1ELF3 20197403 PTHR10210:SF57 RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER RIBOSE-PHOSPHATE DIPHOSPHOKINASE carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;transferase activity#GO:0016740;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;transferase activity, transferring phosphorus-containing groups#GO:0016772;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168;ATP binding#GO:0005524 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695 nucleotide kinase#PC00172;kinase#PC00137 HELRO|EnsemblGenome=HelroG69983|UniProtKB=T1G010 T1G010 20214408 PTHR45134:SF22 OS08G0543275 PROTEIN G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG187204|UniProtKB=T1FP76 T1FP76 20210623 PTHR11109:SF7 GTP CYCLOHYDROLASE I GTP CYCLOHYDROLASE 1 carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;cation binding#GO:0043169;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167 cellular aromatic compound metabolic process#GO:0006725;organic hydroxy compound metabolic process#GO:1901615;heterocycle metabolic process#GO:0046483;alcohol biosynthetic process#GO:0046165;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic hydroxy compound biosynthetic process#GO:1901617;alcohol metabolic process#GO:0006066;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 Tetrahydrofolate biosynthesis#P02742>GTP cyclohydrolase#P02951 HELRO|EnsemblGenome=HelroG110176|UniProtKB=T1EF02 T1EF02 20195154 PTHR43272:SF83 LONG-CHAIN-FATTY-ACID--COA LIGASE ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J long-chain fatty acid-CoA ligase activity#GO:0004467;ligase activity#GO:0016874;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG140872|UniProtKB=T1EJ19 T1EJ19 20196569 PTHR10068:SF14 BONE MARROW PROTEOGLYCAN CELL WALL ADHESIN EAP1 extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG193676|UniProtKB=T1FV90 T1FV90 20212736 PTHR12413:SF2 DOLICHYL GLYCOSYLTRANSFERASE DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED glucosyltransferase activity#GO:0046527;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;cellular lipid metabolic process#GO:0044255;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG76766|UniProtKB=T1G2P2 T1G2P2 20215340 PTHR23257:SF981 SERINE-THREONINE PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG110500|UniProtKB=T1EF29 T1EF29 20195181 PTHR23235:SF158 KRUEPPEL-LIKE TRANSCRIPTION FACTOR C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG159882|UniProtKB=T1EPH7 T1EPH7 20198477 PTHR47143:SF1 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS ION_TRANS DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810 transmembrane transporter complex#GO:1902495;membrane protein complex#GO:0098796;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;membrane#GO:0016020;transporter complex#GO:1990351 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG175490|UniProtKB=T1F9B6 T1F9B6 20205415 PTHR21461:SF69 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 glycosylation#GO:0070085;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG173887|UniProtKB=T1F7C1 T1F7C1 20204720 PTHR11239:SF14 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;RNA polymerase activity#GO:0097747;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;RNA polymerase I activity#GO:0001054 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;transcription by RNA polymerase I#GO:0006360;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;RNA polymerase I complex#GO:0005736;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG193513|UniProtKB=T1FV26 T1FV26 20212672 PTHR10408:SF7 STEROL O-ACYLTRANSFERASE DIACYLGLYCEROL O-ACYLTRANSFERASE 1 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;O-acyltransferase activity#GO:0008374 lipid metabolic process#GO:0006629;triglyceride metabolic process#GO:0006641;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;acylglycerol metabolic process#GO:0006639;lipid biosynthetic process#GO:0008610;primary metabolic process#GO:0044238;neutral lipid metabolic process#GO:0006638;glycerolipid metabolic process#GO:0046486;triglyceride biosynthetic process#GO:0019432;cellular lipid metabolic process#GO:0044255;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 transferase#PC00220;acyltransferase#PC00042;metabolite interconversion enzyme#PC00262 Androgen/estrogene/progesterone biosynthesis#P02727>Cholesterol acyltransferase#P02829 HELRO|EnsemblGenome=HelroG168280|UniProtKB=T1F0E4 T1F0E4 20202294 PTHR10725:SF79 THAP DOMAIN-CONTAINING PROTEIN 9 TRANSPOSABLE ELEMENT P TRANSPOSASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183384|UniProtKB=T1FJJ6 T1FJJ6 20208995 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG67109|UniProtKB=T1FYW5 T1FYW5 20214013 PTHR11208:SF125 RNA-BINDING PROTEIN RELATED KH DOMAIN-CONTAINING RNA-BINDING PROTEIN QKI nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of RNA splicing#GO:0043484;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of mRNA processing#GO:0050684;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;regulation of mRNA metabolic process#GO:1903311 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG181548|UniProtKB=T1FH35 T1FH35 20208134 PTHR14865:SF2 CST COMPLEX SUBUNIT CTC1 CST COMPLEX SUBUNIT CTC1 telomeric DNA binding#GO:0042162;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;single-stranded DNA binding#GO:0003697;DNA binding#GO:0003677 positive regulation of nitrogen compound metabolic process#GO:0051173;telomere maintenance via telomere lengthening#GO:0010833;cellular aromatic compound metabolic process#GO:0006725;telomere organization#GO:0032200;regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA metabolic process#GO:0051052;positive regulation of cellular metabolic process#GO:0031325;nucleobase-containing compound metabolic process#GO:0006139;telomere maintenance#GO:0000723;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;positive regulation of metabolic process#GO:0009893;nitrogen compound metabolic process#GO:0006807;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;primary metabolic process#GO:0044238;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;chromosome organization#GO:0051276;organelle organization#GO:0006996;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;DNA metabolic process#GO:0006259;regulation of cellular metabolic process#GO:0031323 nuclear telomere cap complex#GO:0000783;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome, telomeric region#GO:0000781;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;chromosomal region#GO:0098687;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG168787|UniProtKB=T1F0Z0 T1F0Z0 20202490 PTHR24274:SF1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 161 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 161 organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;motile cilium#GO:0031514;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cilium#GO:0005929 structural protein#PC00211 HELRO|EnsemblGenome=HelroG81881|UniProtKB=T1G4K2 T1G4K2 20216000 PTHR24248:SF199 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR IP13425P-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;regulation of cell communication#GO:0010646;cellular response to stimulus#GO:0051716;regulation of MAPK cascade#GO:0043408;signal transduction#GO:0007165;positive regulation of signal transduction#GO:0009967;regulation of signaling#GO:0023051;cell communication#GO:0007154;cellular process#GO:0009987;regulation of intracellular signal transduction#GO:1902531;positive regulation of MAPK cascade#GO:0043410;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;positive regulation of response to stimulus#GO:0048584;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;positive regulation of cell communication#GO:0010647;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG180178|UniProtKB=T1FFJ6 T1FFJ6 20207595 PTHR20661:SF0 PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN transferase activity#GO:0016740;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;O-acyltransferase activity#GO:0008374 lipid metabolic process#GO:0006629;cellular localization#GO:0051641;carbohydrate derivative metabolic process#GO:1901135;phospholipid biosynthetic process#GO:0008654;macromolecule localization#GO:0033036;macromolecule modification#GO:0043412;phosphatidylinositol biosynthetic process#GO:0006661;organophosphate biosynthetic process#GO:0090407;glycolipid metabolic process#GO:0006664;protein modification process#GO:0036211;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;protein localization to plasma membrane#GO:0072659;localization within membrane#GO:0051668;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein localization to membrane#GO:0072657;glycerolipid biosynthetic process#GO:0045017;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;liposaccharide metabolic process#GO:1903509;membrane lipid biosynthetic process#GO:0046467;GPI anchor metabolic process#GO:0006505;lipoprotein biosynthetic process#GO:0042158;primary metabolic process#GO:0044238;protein localization#GO:0008104;localization#GO:0051179;carbohydrate derivative biosynthetic process#GO:1901137;GPI anchor biosynthetic process#GO:0006506;protein localization to cell periphery#GO:1990778;cellular macromolecule localization#GO:0070727;membrane lipid metabolic process#GO:0006643;glycerophospholipid biosynthetic process#GO:0046474;glycolipid biosynthetic process#GO:0009247;organophosphate metabolic process#GO:0019637;lipoprotein metabolic process#GO:0042157;cellular lipid metabolic process#GO:0044255 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 acyltransferase#PC00042;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG177891|UniProtKB=T1FCF5 T1FCF5 20206504 PTHR24250:SF27 CHYMOTRYPSIN-RELATED ELASTASE 2 LIKE hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG142296|UniProtKB=T1EJ54 T1EJ54 20196604 PTHR18945:SF865 NEUROTRANSMITTER GATED ION CHANNEL NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA7, ISOFORM E ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG66624|UniProtKB=T1FYN3 T1FYN3 20213931 PTHR48012:SF10 STERILE20-LIKE KINASE, ISOFORM B-RELATED FI20177P1 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG77336|UniProtKB=T1G2W4 T1G2W4 20215412 PTHR11920:SF501 GUANYLYL CYCLASE GUANYLATE CYCLASE 32E adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG158789|UniProtKB=T1EN96 T1EN96 20198046 PTHR46954:SF1 C2H2-TYPE DOMAIN-CONTAINING PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG181759|UniProtKB=T1FHA6 T1FHA6 20208205 PTHR13060:SF0 SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2 PROTEIN ECDYSONELESS HOMOLOG membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG82276|UniProtKB=T1G4P9 T1G4P9 20216047 PTHR11893:SF36 INNEXIN INNEXIN-5 cell junction protein#PC00070;gap junction#PC00105 HELRO|EnsemblGenome=HelroG166854|UniProtKB=T1EYM8 T1EYM8 20201678 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG81835|UniProtKB=T1G4J4 T1G4J4 20215992 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG189564|UniProtKB=T1FR57 T1FR57 20211304 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG161781|UniProtKB=T1ERW8 T1ERW8 20199318 PTHR10957:SF1 RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1 GTPASE-GDP DISSOCIATION STIMULATOR VIMAR cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG163115|UniProtKB=T1ETP0 T1ETP0 20199940 PTHR44086:SF10 THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3 thiosulfate sulfurtransferase activity#GO:0004792;transferase activity#GO:0016740;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity#GO:0003824;sulfurtransferase activity#GO:0016783 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG81974|UniProtKB=T1G4L1 T1G4L1 20216009 PTHR13376:SF0 INTRAFLAGELLAR TRANSPORT PROTEIN 46 HOMOLOG INTRAFLAGELLAR TRANSPORT PROTEIN 46 HOMOLOG cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;cilium assembly#GO:0060271;cell projection organization#GO:0030030;transport#GO:0006810;microtubule-based movement#GO:0007018;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;transport along microtubule#GO:0010970;cell projection assembly#GO:0030031;intraciliary transport#GO:0042073;localization#GO:0051179;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based transport#GO:0099111;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;organelle organization#GO:0006996;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;plasma membrane bounded cell projection assembly#GO:0120031;protein-containing complex localization#GO:0031503 microtubule organizing center#GO:0005815;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;motile cilium#GO:0031514;intraciliary transport particle B#GO:0030992;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929;intraciliary transport particle#GO:0030990 HELRO|EnsemblGenome=HelroG180182|UniProtKB=T1FFJ8 T1FFJ8 20207597 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG184649|UniProtKB=T1FLN9 T1FLN9 20209738 PTHR24391:SF27 HISTONE H4 TRANSCRIPTION FACTOR-RELATED ZINC FINGER PROTEIN 1 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG84100|UniProtKB=T1G5E7 T1G5E7 20216294 PTHR12922:SF7 UBIQUINONE BIOSYNTHESIS PROTEIN UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL HELRO|EnsemblGenome=HelroG85499|UniProtKB=T1G5Y1 T1G5Y1 20216478 PTHR24096:SF149 LONG-CHAIN-FATTY-ACID--COA LIGASE AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED ligase activity#GO:0016874;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 metabolite interconversion enzyme#PC00262;ligase#PC00142 HELRO|EnsemblGenome=HelroG124735|UniProtKB=T1EH26 T1EH26 20195876 PTHR14677:SF20 ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED ZINC FINGER AN1-TYPE CONTAINING 2A-RELATED RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG93842|UniProtKB=T1G8X9 T1G8X9 20217526 PTHR10869:SF244 PROLYL 4-HYDROXYLASE ALPHA SUBUNIT PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2 2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;dioxygenase activity#GO:0051213 oxoacid metabolic process#GO:0043436;heterocycle metabolic process#GO:0046483;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular modified amino acid metabolic process#GO:0006575;protein hydroxylation#GO:0018126;alpha-amino acid metabolic process#GO:1901605;protein metabolic process#GO:0019538;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185645|UniProtKB=T1FN32 T1FN32 20210231 PTHR45699:SF3 60S ACIDIC RIBOSOMAL PROTEIN P0 LARGE RIBOSOMAL SUBUNIT PROTEIN UL10 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;rRNA binding#GO:0019843;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular component biogenesis#GO:0044085;peptide metabolic process#GO:0006518;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;ribosomal large subunit biogenesis#GO:0042273;translation#GO:0006412;protein-RNA complex assembly#GO:0022618;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;ribosomal large subunit assembly#GO:0000027;ribosome biogenesis#GO:0042254;non-membrane-bounded organelle assembly#GO:0140694;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cytoplasmic translation#GO:0002181;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;peptide biosynthetic process#GO:0043043;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;ribonucleoprotein complex biogenesis#GO:0022613;protein-RNA complex organization#GO:0071826 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG110263|UniProtKB=T1EF09 T1EF09 20195161 PTHR45994:SF1 FI21225P1 FI21225P1 protein binding#GO:0005515;heat shock protein binding#GO:0031072;binding#GO:0005488;Hsp90 protein binding#GO:0051879 macromolecule biosynthetic process#GO:0009059;chaperone-mediated protein folding#GO:0061077;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG113396|UniProtKB=T1EFS2 T1EFS2 20195424 PTHR24409:SF407 ZINC FINGER PROTEIN 142 C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG85873|UniProtKB=T1G638 T1G638 20216535 PTHR13832:SF699 PROTEIN PHOSPHATASE 2C INTEGRIN-LINKED KINASE-ASSOCIATED SERINE_THREONINE PHOSPHATASE 2C macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;dephosphorylation#GO:0016311;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG144008|UniProtKB=T1EJD4 T1EJD4 20196684 PTHR24230:SF76 G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;neuropeptide signaling pathway#GO:0007218;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG161716|UniProtKB=T1ERT8 T1ERT8 20199288 PTHR32178:SF6 FAM187 IG-LIKE DOMAIN-CONTAINING PROTEIN immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG85923|UniProtKB=T1G644 T1G644 20216541 PTHR23427:SF1 SURFEIT LOCUS PROTEIN SURFEIT LOCUS PROTEIN 4 endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cellular process#GO:0009987;Golgi organization#GO:0007030;organelle organization#GO:0006996 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG165794|UniProtKB=T1EXA6 T1EXA6 20201206 PTHR11614:SF87 PHOSPHOLIPASE-RELATED MONOGLYCERIDE LIPASE hydrolase activity#GO:0016787;lipase activity#GO:0016298;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 cellular anatomical entity#GO:0110165;membrane#GO:0016020 phospholipase#PC00186;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG72444|UniProtKB=T1G102 T1G102 20214750 PTHR22838:SF4 WD REPEAT PROTEIN 26-RELATED WD REPEAT-CONTAINING PROTEIN 13 protein-containing complex binding#GO:0044877;chromatin binding#GO:0003682;binding#GO:0005488 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG168358|UniProtKB=T1F0G7 T1F0G7 20202317 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG191143|UniProtKB=T1FSN1 T1FSN1 20211828 PTHR18945:SF914 NEUROTRANSMITTER GATED ION CHANNEL NEUROTRANSMITTER-GATED ION-CHANNEL LIGAND-BINDING DOMAIN-CONTAINING PROTEIN transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission#GO:0007268;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 cell junction#GO:0030054;synapse#GO:0045202;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;neuron projection#GO:0043005 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG163146|UniProtKB=T1ETQ4 T1ETQ4 20199954 PTHR24034:SF209 EGF-LIKE DOMAIN-CONTAINING PROTEIN EGF-LIKE DOMAIN-CONTAINING PROTEIN extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG166000|UniProtKB=T1EXK2 T1EXK2 20201302 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG162157|UniProtKB=T1ESA5 T1ESA5 20199455 PTHR15126:SF4 SH3-BINDING SH3 DOMAIN-BINDING PROTEIN 2 HELRO|EnsemblGenome=HelroG72974|UniProtKB=T1G182 T1G182 20214830 PTHR45636:SF52 PAIRED BOX PROTEIN PAX-6-RELATED-RELATED PAIRED DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG186366|UniProtKB=T1FNY8 T1FNY8 20210535 PTHR45673:SF1 SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;protein binding#GO:0005515;calmodulin binding#GO:0005516;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;calcium-mediated signaling#GO:0019722;regulation of cellular process#GO:0050794;calcineurin-mediated signaling#GO:0097720;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052 protein serine/threonine phosphatase complex#GO:0008287;cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 B cell activation#P00010>Calcineurin#P00386;Wnt signaling pathway#P00057>Calcineurin#P01446 HELRO|EnsemblGenome=HelroG166844|UniProtKB=T1EYM1 T1EYM1 20201671 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163581|UniProtKB=T1EU89 T1EU89 20200139 PTHR12766:SF7 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DEATH DOMAIN-ASSOCIATED PROTEIN 6 FAS signaling pathway#P00020>DAXX#P00602;Apoptosis signaling pathway#P00006>DAXX#P00296 HELRO|EnsemblGenome=HelroG108864|UniProtKB=T1EEN2 T1EEN2 20195034 PTHR24058:SF28 DUAL SPECIFICITY PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE MINIBRAIN transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;peptidyl-amino acid modification#GO:0018193;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;peptidyl-threonine phosphorylation#GO:0018107;nitrogen compound metabolic process#GO:0006807;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG131009|UniProtKB=T1EHU9 T1EHU9 20196149 PTHR15574:SF43 WD REPEAT DOMAIN-CONTAINING FAMILY DDB1- AND CUL4-ASSOCIATED FACTOR 5 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of lipid metabolic process#GO:0019216;regulation of lipid biosynthetic process#GO:0046890;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;negative regulation of cellular biosynthetic process#GO:0031327 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;Cul4-RING E3 ubiquitin ligase complex#GO:0080008 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG183163|UniProtKB=T1FJ87 T1FJ87 20208886 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173523|UniProtKB=T1F6X7 T1F6X7 20204576 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED FMRFAMIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG154397|UniProtKB=T1ELE7 T1ELE7 20197397 PTHR10655:SF68 LYSOPHOSPHOLIPASE-RELATED PALMITOYL-PROTEIN HYDROLASE hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;thiolester hydrolase activity#GO:0016790 macromolecule catabolic process#GO:0009057;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;catabolic process#GO:0009056;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;lipoprotein metabolic process#GO:0042157;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 phospholipase#PC00186;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG188986|UniProtKB=T1FQJ1 T1FQJ1 20211088 PTHR12800:SF4 CDC37-RELATED HSP90 CO-CHAPERONE CDC37 protein binding#GO:0005515;heat shock protein binding#GO:0031072;protein-folding chaperone binding#GO:0051087;unfolded protein binding#GO:0051082;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;regulation of protein stability#GO:0031647;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein stabilization#GO:0050821;primary metabolic process#GO:0044238;regulation of biological quality#GO:0065008;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;biological regulation#GO:0065007;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG88624|UniProtKB=T1G745 T1G745 20216892 PTHR23123:SF37 PHD/F-BOX CONTAINING PROTEIN JMJC DOMAIN-CONTAINING PROTEIN-RELATED histone modifying activity#GO:0140993;molecular adaptor activity#GO:0060090;demethylase activity#GO:0032451;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;histone demethylase activity#GO:0032452;catalytic activity#GO:0003824;protein-macromolecule adaptor activity#GO:0030674;catalytic activity, acting on a protein#GO:0140096 macromolecule modification#GO:0043412;regulation of DNA-templated transcription#GO:0006355;macromolecule metabolic process#GO:0043170;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;protein metabolic process#GO:0019538;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG161007|UniProtKB=T1ER01 T1ER01 20199001 PTHR24343:SF558 SERINE/THREONINE KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG91246|UniProtKB=T1G817 T1G817 20217214 PTHR15192:SF8 PROTEIN CBG05349 FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190024|UniProtKB=T1FRL8 T1FRL8 20211465 PTHR12260:SF6 DAMAGE-CONTROL PHOSPHATASE ARMT1 DAMAGE-CONTROL PHOSPHATASE ARMT1 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 response to stimulus#GO:0050896;DNA damage response#GO:0006974;cellular response to stimulus#GO:0051716;response to stress#GO:0006950;cellular process#GO:0009987;cellular response to stress#GO:0033554 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG164079|UniProtKB=T1EUW1 T1EUW1 20200361 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG183585|UniProtKB=T1FJV8 T1FJV8 20209107 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189731|UniProtKB=T1FRB1 T1FRB1 20211358 PTHR23320:SF167 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MARVEL DOMAIN-CONTAINING PROTEIN transporter#PC00227 HELRO|EnsemblGenome=HelroG190416|UniProtKB=T1FRZ3 T1FRZ3 20211590 PTHR12943:SF27 HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER HOMOCYSTEINE-INDUCED ENDOPLASMIC RETICULUM PROTEIN, ISOFORM A response to organic substance#GO:0010033;signal transduction#GO:0007165;endoplasmic reticulum unfolded protein response#GO:0030968;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;cellular response to chemical stimulus#GO:0070887;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to topologically incorrect protein#GO:0035967;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;response to unfolded protein#GO:0006986;cellular response to unfolded protein#GO:0034620;response to topologically incorrect protein#GO:0035966;biological regulation#GO:0065007;cellular response to stress#GO:0033554;signaling#GO:0023052 HELRO|EnsemblGenome=HelroG87750|UniProtKB=T1G6V2 T1G6V2 20216799 PTHR23084:SF263 PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED MORN REPEAT-CONTAINING PROTEIN 1 transferase#PC00220;kinase#PC00137;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG115877|UniProtKB=T1EGB4 T1EGB4 20195616 PTHR45672:SF2 PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED PROTEIN DISULFIDE-ISOMERASE A5 isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;protein disulfide isomerase activity#GO:0003756 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG169877|UniProtKB=T1F2E3 T1F2E3 20202993 PTHR20956:SF12 HEH2P FLYWCH-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG109730|UniProtKB=T1EEW1 T1EEW1 20195113 PTHR24044:SF506 NOTCH LIGAND FAMILY MEMBER NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2-LIKE protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG91172|UniProtKB=T1G807 T1G807 20217204 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG167917|UniProtKB=T1EZY5 T1EZY5 20202135 PTHR47577:SF1 THAP DOMAIN-CONTAINING PROTEIN 6 THAP DOMAIN-CONTAINING PROTEIN 6 HELRO|EnsemblGenome=HelroG175512|UniProtKB=T1F9C5 T1F9C5 20205424 PTHR20875:SF0 EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 6-RELATED GH12158P calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG181518|UniProtKB=T1FH29 T1FH29 20208128 PTHR12317:SF79 DIACYLGLYCEROL O-ACYLTRANSFERASE ACYLTRANSFERASE acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;O-acyltransferase activity#GO:0008374 lipid metabolic process#GO:0006629;triglyceride metabolic process#GO:0006641;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;acylglycerol metabolic process#GO:0006639;lipid biosynthetic process#GO:0008610;primary metabolic process#GO:0044238;neutral lipid metabolic process#GO:0006638;glycerolipid metabolic process#GO:0046486;triglyceride biosynthetic process#GO:0019432;cellular lipid metabolic process#GO:0044255;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG69939|UniProtKB=T1G002 T1G002 20214400 PTHR45910:SF1 N-ALPHA-ACETYLTRANSFERASE 20 N-ALPHA-ACETYLTRANSFERASE 20 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;acetyltransferase activity#GO:0016407;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;peptide alpha-N-acetyltransferase activity#GO:0004596;N-acyltransferase activity#GO:0016410 macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;protein modification process#GO:0036211;gene expression#GO:0010467;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;protein acylation#GO:0043543;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein acetylation#GO:0006473;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;acetyltransferase complex#GO:1902493;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG174326|UniProtKB=T1F805 T1F805 20204954 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG65123|UniProtKB=T1FY34 T1FY34 20213732 PTHR24180:SF58 CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 49 kinase inhibitor#PC00139 HELRO|EnsemblGenome=HelroG130000|UniProtKB=T1EHS9 T1EHS9 20196129 PTHR23337:SF3 ZINC FINGER CW-TYPE COILED-COIL DOMAIN PROTEIN 1 MORC FAMILY CW-TYPE ZINC FINGER 2 HELRO|EnsemblGenome=HelroG192396|UniProtKB=T1FTW6 T1FTW6 20212263 PTHR24221:SF654 ATP-BINDING CASSETTE SUB-FAMILY B ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 6 transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG188784|UniProtKB=T1FQC8 T1FQC8 20211025 PTHR22692:SF33 MYOSIN VII, XV MYOSIN actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG93730|UniProtKB=T1G8X5 T1G8X5 20217522 PTHR44360:SF1 DNAJ HOMOLOG SUBFAMILY B MEMBER 9 DNAJ HOMOLOG SUBFAMILY B MEMBER 9 protein binding#GO:0005515;protein-folding chaperone binding#GO:0051087;binding#GO:0005488 response to organic substance#GO:0010033;macromolecule catabolic process#GO:0009057;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;response to organonitrogen compound#GO:0010243;ERAD pathway#GO:0036503;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG164773|UniProtKB=T1EVS8 T1EVS8 20200678 PTHR23048:SF0 MYOSIN LIGHT CHAIN 1, 3 CALMODULIN LIKE 3 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;myosin complex#GO:0016459;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG94619|UniProtKB=T1G920 T1G920 20217567 PTHR13377:SF3 PLACENTAL PROTEIN 6 TRANSMEMBRANE PROTEIN 115 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;Golgi vesicle transport#GO:0048193;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;transport#GO:0006810 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG192150|UniProtKB=T1FTM8 T1FTM8 20212175 PTHR23303:SF14 CARBOXYPEPTIDASE REGULATORY REGION-CONTAINING BOS COMPLEX SUBUNIT NOMO1-RELATED cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG115102|UniProtKB=T1EG64 T1EG64 20195566 PTHR23142:SF2 PRE-MRNA-SPLICING FACTOR 38A-RELATED PRE-MRNA-SPLICING FACTOR 38B ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;precatalytic spliceosome#GO:0071011;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG172395|UniProtKB=T1F593 T1F593 20203992 PTHR44733:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 22 DNAJ HOMOLOG SUBFAMILY C MEMBER 22 cellular anatomical entity#GO:0110165;membrane#GO:0016020 chaperone#PC00072 HELRO|EnsemblGenome=HelroG124201|UniProtKB=T1EH03 T1EH03 20195853 PTHR44313:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 17 DNAJ HOMOLOG SUBFAMILY C MEMBER 17 cellular aromatic compound metabolic process#GO:0006725;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;mRNA metabolic process#GO:0016071;cellular component disassembly#GO:0022411;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;protein-containing complex disassembly#GO:0032984;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG183590|UniProtKB=T1FJW2 T1FJW2 20209111 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189478|UniProtKB=T1FR32 T1FR32 20211279 PTHR24104:SF47 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED E3 UBIQUITIN-PROTEIN LIGASE NHLRC1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191185|UniProtKB=T1FSQ1 T1FSQ1 20211848 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG129198|UniProtKB=T1EHR4 T1EHR4 20196114 PTHR45134:SF22 OS08G0543275 PROTEIN G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165230|UniProtKB=T1EWG9 T1EWG9 20200919 PTHR45901:SF3 PROTEIN CBG12474 LIPOXYGENASE HOMOLOGY DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG160398|UniProtKB=T1EQ74 T1EQ74 20198724 PTHR21237:SF23 GRPE PROTEIN GRPE PROTEIN HOMOLOG, MITOCHONDRIAL nucleotide binding#GO:0000166;unfolded protein binding#GO:0051082;small molecule binding#GO:0036094;molecular function regulator activity#GO:0098772;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;protein binding#GO:0005515 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG182646|UniProtKB=T1FIJ3 T1FIJ3 20208642 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166441|UniProtKB=T1EY50 T1EY50 20201500 PTHR19871:SF14 BETA TRANSDUCIN-RELATED PROTEIN DUF4062 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190718|UniProtKB=T1FS84 T1FS84 20211681 PTHR24123:SF141 ANKYRIN REPEAT-CONTAINING ANKYRIN 2, ISOFORM U scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG98384|UniProtKB=T1G9M1 T1G9M1 20217767 PTHR19269:SF45 TROPOMYOSIN TROPOMYOSIN-1, ISOFORMS 33_34 cytoskeletal protein#PC00085;actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG169182|UniProtKB=T1F1J4 T1F1J4 20202694 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG90060|UniProtKB=T1G7K5 T1G7K5 20217052 PTHR12263:SF0 VACUOLAR ATP SYNTHASE SUBUNIT H V-TYPE PROTON ATPASE SUBUNIT localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 ATP synthase#PC00002;transporter#PC00227 HELRO|EnsemblGenome=HelroG180929|UniProtKB=T1FGF7 T1FGF7 20207906 PTHR46600:SF1 THAP DOMAIN-CONTAINING THAP DOMAIN-CONTAINING PROTEIN 1 zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG63746|UniProtKB=T1FXJ6 T1FXJ6 20213544 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163396|UniProtKB=T1EU00 T1EU00 20200050 PTHR46825:SF9 D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG180796|UniProtKB=T1FGA3 T1FGA3 20207852 PTHR31362:SF0 GLYCOSYLTRANSFERASE STELLO1-RELATED EXOSTOSIN DOMAIN-CONTAINING PROTEIN-RELATED glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG179371|UniProtKB=T1FEM2 T1FEM2 20207271 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192254|UniProtKB=T1FTR7 T1FTR7 20212214 PTHR46290:SF1 DI-N-ACETYLCHITOBIASE DI-N-ACETYLCHITOBIASE HELRO|EnsemblGenome=HelroG176712|UniProtKB=T1FAT3 T1FAT3 20205932 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179186|UniProtKB=T1FEB7 T1FEB7 20207166 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG105047|UniProtKB=T1EDQ0 T1EDQ0 20194702 PTHR47979:SF38 DRAB11-RELATED GH01619P GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;transport#GO:0006810 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 small GTPase#PC00208 PDGF signaling pathway#P00047>Ras#P01154 HELRO|EnsemblGenome=HelroG165521|UniProtKB=T1EWY8 T1EWY8 20201088 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG185416|UniProtKB=T1FMS6 T1FMS6 20210125 PTHR11715:SF3 GLYCINE CLEAVAGE SYSTEM H PROTEIN GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED macromolecule modification#GO:0043412;protein modification process#GO:0036211;gene expression#GO:0010467;organonitrogen compound catabolic process#GO:1901565;peptidyl-amino acid modification#GO:0018193;biosynthetic process#GO:0009058;amino acid catabolic process#GO:0009063;nitrogen compound metabolic process#GO:0006807;alpha-amino acid metabolic process#GO:1901605;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;protein metabolic process#GO:0019538;L-amino acid metabolic process#GO:0170033;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;protein maturation#GO:0051604;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG74975|UniProtKB=T1G1Z0 T1G1Z0 20215088 PTHR45694:SF18 GLUTAREDOXIN 2 GLUTAREDOXIN-1-RELATED disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;response to stress#GO:0006950;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;cellular response to oxidative stress#GO:0034599;response to oxidative stress#GO:0006979;cellular response to stress#GO:0033554;cellular process#GO:0009987 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG89773|UniProtKB=T1G7H3 T1G7H3 20217020 PTHR10283:SF82 SOLUTE CARRIER FAMILY 13 MEMBER SOLUTE CARRIER FAMILY 13 MEMBER 2 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG159665|UniProtKB=T1EPA5 T1EPA5 20198405 PTHR16119:SF17 TRANSMEMBRANE PROTEIN 144 TRANSMEMBRANE PROTEIN 144 HELRO|EnsemblGenome=HelroG192564|UniProtKB=T1FU31 T1FU31 20212327 PTHR10139:SF1 DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11 DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11 hydrolase activity, acting on ester bonds#GO:0016788;DNA endonuclease activity#GO:0004520;nuclease activity#GO:0004518;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787;endonuclease activity#GO:0004519;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097 DNA repair#GO:0006281;DNA damage checkpoint signaling#GO:0000077;mitotic cell cycle checkpoint signaling#GO:0007093;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;cell cycle checkpoint signaling#GO:0000075;DNA damage response#GO:0006974;mitotic cell cycle#GO:0000278;nitrogen compound metabolic process#GO:0006807;recombinational repair#GO:0000725;meiosis I cell cycle process#GO:0061982;reproductive process#GO:0022414;intracellular signal transduction#GO:0035556;organic substance metabolic process#GO:0071704;regulation of cell cycle G2/M phase transition#GO:1902749;negative regulation of cell cycle#GO:0045786;regulation of mitotic cell cycle phase transition#GO:1901990;macromolecule metabolic process#GO:0043170;meiotic cell cycle#GO:0051321;regulation of cell cycle phase transition#GO:1901987;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cell communication#GO:0007154;cellular nitrogen compound metabolic process#GO:0034641;double-strand break repair via homologous recombination#GO:0000724;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;regulation of cell cycle process#GO:0010564;cellular component organization or biogenesis#GO:0071840;double-strand break repair via nonhomologous end joining#GO:0006303;response to stress#GO:0006950;reproduction#GO:0000003;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;chromosome organization#GO:0051276;regulation of cellular process#GO:0050794;mitotic G2/M transition checkpoint#GO:0044818;sexual reproduction#GO:0019953;mitotic G2 DNA damage checkpoint signaling#GO:0007095;cellular response to stress#GO:0033554;cellular aromatic compound metabolic process#GO:0006725;signal transduction#GO:0007165;negative regulation of biological process#GO:0048519;double-strand break repair#GO:0006302;telomere organization#GO:0032200;cell cycle process#GO:0022402;negative regulation of cell cycle process#GO:0010948;mitotic cell cycle process#GO:1903047;telomere maintenance#GO:0000723;negative regulation of mitotic cell cycle phase transition#GO:1901991;organic cyclic compound metabolic process#GO:1901360;meiotic cell cycle process#GO:1903046;signal transduction in response to DNA damage#GO:0042770;signaling#GO:0023052;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;negative regulation of cell cycle G2/M phase transition#GO:1902750;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of mitotic cell cycle#GO:0045930;cellular process#GO:0009987;DNA integrity checkpoint signaling#GO:0031570;meiotic DNA double-strand break formation#GO:0042138;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;organelle organization#GO:0006996;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;mitotic DNA integrity checkpoint signaling#GO:0044774;regulation of G2/M transition of mitotic cell cycle#GO:0010389;mitotic DNA damage checkpoint signaling#GO:0044773;regulation of mitotic cell cycle#GO:0007346;DNA metabolic process#GO:0006259 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;site of DNA damage#GO:0090734;membrane-bounded organelle#GO:0043227;site of double-strand break#GO:0035861;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG79884|UniProtKB=T1G3V0 T1G3V0 20215748 PTHR11787:SF8 RAB GDP-DISSOCIATION INHIBITOR RAB GDP DISSOCIATION INHIBITOR nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;cellular process#GO:0009987;transport#GO:0006810 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG172618|UniProtKB=T1F5N0 T1F5N0 20204129 PTHR47510:SF3 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170245|UniProtKB=T1F2T8 T1F2T8 20203137 PTHR24031:SF301 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX18 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of LSU-rRNA#GO:0000470;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG189878|UniProtKB=T1FRG1 T1FRG1 20211408 PTHR18945:SF925 NEUROTRANSMITTER GATED ION CHANNEL DUF4706 DOMAIN-CONTAINING PROTEIN ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG188261|UniProtKB=T1FPT3 T1FPT3 20210830 PTHR23193:SF23 NUCLEAR PORE COMPLEX PROTEIN NUP NUCLEAR PORE COMPLEX PROTEIN NUP153 signal sequence binding#GO:0005048;structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056;binding#GO:0005488;amide binding#GO:0033218;peptide binding#GO:0042277 cellular localization#GO:0051641;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;transport#GO:0006810;protein localization to nucleus#GO:0034504;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of protein localization#GO:0045184;RNA localization#GO:0006403;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;protein import into nucleus#GO:0006606;cellular macromolecule localization#GO:0070727;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169;import into nucleus#GO:0051170 envelope#GO:0031975;nuclear pore#GO:0005643;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG155168|UniProtKB=T1ELH4 T1ELH4 20197424 PTHR24276:SF91 POLYSERASE-RELATED AT26814P-RELATED hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG98638|UniProtKB=T1G9N9 T1G9N9 20217785 PTHR12454:SF11 TRIMERIC INTRACELLULAR CATION CHANNEL GH25683P ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG111355|UniProtKB=T1EFA5 T1EFA5 20195257 PTHR45965:SF3 INACTIVE RHOMBOID PROTEIN INACTIVE RHOMBOID PROTEIN 1 regulation of cell communication#GO:0010646;regulation of protein secretion#GO:0050708;regulation of signaling#GO:0023051;regulation of secretion by cell#GO:1903530;regulation of localization#GO:0032879;regulation of cellular localization#GO:0060341;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;regulation of transport#GO:0051049;regulation of cellular process#GO:0050794;regulation of secretion#GO:0051046;regulation of signal transduction#GO:0009966;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;biological regulation#GO:0065007;regulation of ERBB signaling pathway#GO:1901184;regulation of protein transport#GO:0051223;regulation of establishment of protein localization#GO:0070201;regulation of protein localization#GO:0032880 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG70650|UniProtKB=T1G098 T1G098 20214496 PTHR11849:SF191 ETS ECDYSONE-INDUCED PROTEIN 74EF ISOFORM B transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 PDGF signaling pathway#P00047>Ets#P01167 HELRO|EnsemblGenome=HelroG186273|UniProtKB=T1FNW3 T1FNW3 20210510 PTHR10165:SF103 LIPID PHOSPHATE PHOSPHATASE PHOSPHOLIPID PHOSPHATASE HOMOLOG 1.2 HOMOLOG hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 phospholipid dephosphorylation#GO:0046839;lipid metabolic process#GO:0006629;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;cellular metabolic process#GO:0044237;cell communication#GO:0007154;lipid modification#GO:0030258;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;dephosphorylation#GO:0016311;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG190837|UniProtKB=T1FSC6 T1FSC6 20211723 PTHR15708:SF4 ACTIN BUNDLING/MISSING IN METASTASIS-RELATED FI21477P1-RELATED cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;lipid binding#GO:0008289;phospholipid binding#GO:0005543;actin binding#GO:0003779;binding#GO:0005488 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cell projection organization#GO:0030030;membrane organization#GO:0061024;cellular component organization#GO:0016043;cellular process#GO:0009987;cell projection assembly#GO:0030031 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;side of membrane#GO:0098552;cytoplasmic side of plasma membrane#GO:0009898;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG186656|UniProtKB=T1FP20 T1FP20 20210567 PTHR22692:SF33 MYOSIN VII, XV MYOSIN actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG88718|UniProtKB=T1G757 T1G757 20216904 PTHR24204:SF8 INSULIN GENE ENHANCER PROTEIN TAILUP, ISOFORM A cellular developmental process#GO:0048869;neurogenesis#GO:0022008;cell projection organization#GO:0030030;multicellular organism development#GO:0007275;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;cell morphogenesis#GO:0000902;cellular component organization#GO:0016043;cell fate commitment#GO:0045165;cellular process#GO:0009987;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;cell fate specification#GO:0001708;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;cell differentiation#GO:0030154;system development#GO:0048731;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;neuron differentiation#GO:0030182;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;axonogenesis#GO:0007409;plasma membrane bounded cell projection morphogenesis#GO:0120039;generation of neurons#GO:0048699 HELRO|EnsemblGenome=HelroG178964|UniProtKB=T1FDZ4 T1FDZ4 20207043 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG194818|UniProtKB=T1FWG3 T1FWG3 20213158 PTHR33447:SF2 GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE transferase activity#GO:0016740;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824 cellular response to stimulus#GO:0051716;secondary metabolic process#GO:0019748;cellular response to chemical stimulus#GO:0070887;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;amide biosynthetic process#GO:0043604;response to stimulus#GO:0050896;detoxification#GO:0098754;peptide biosynthetic process#GO:0043043;response to stress#GO:0006950;secondary metabolite biosynthetic process#GO:0044550;response to chemical#GO:0042221;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;response to toxic substance#GO:0009636;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG77890|UniProtKB=T1G352 T1G352 20215500 PTHR11802:SF472 SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE SERINE CARBOXYPEPTIDASE CPVL-RELATED hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171;carboxypeptidase activity#GO:0004180 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG180623|UniProtKB=T1FG36 T1FG36 20207785 PTHR14043:SF2 CCAAT DISPLACEMENT PROTEIN-RELATED HOMEOBOX PROTEIN CUT homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG88345|UniProtKB=T1G716 T1G716 20216863 PTHR46205:SF3 LOQUACIOUS, ISOFORM B LOQUACIOUS, ISOFORM B HELRO|EnsemblGenome=HelroG167931|UniProtKB=T1EZZ4 T1EZZ4 20202144 PTHR44394:SF1 BETA-ALANINE-ACTIVATING ENZYME BETA-ALANINE-ACTIVATING ENZYME ligase#PC00142 HELRO|EnsemblGenome=HelroG171151|UniProtKB=T1F3V4 T1F3V4 20203503 PTHR12694:SF8 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;gene expression#GO:0010467;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 RNA metabolism protein#PC00031;general transcription factor#PC00259 General transcription regulation#P00023>TFIIA complex#P00662;Transcription regulation by bZIP transcription factor#P00055>TFIIA complex#P01390 HELRO|EnsemblGenome=HelroG185062|UniProtKB=T1FMC4 T1FMC4 20209973 PTHR42861:SF127 CALCIUM-TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE SARCOPLASMIC_ENDOPLASMIC RETICULUM TYPE calcium ion transmembrane transporter activity#GO:0015085;inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;P-type ion transporter activity#GO:0015662;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;inorganic cation transmembrane transporter activity#GO:0022890;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;calcium ion transport#GO:0006816;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;membrane#GO:0016020 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG106264|UniProtKB=T1EE12 T1EE12 20194814 PTHR10190:SF16 EYES ABSENT DEVELOPMENTAL PROTEIN EYES ABSENT hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of DNA repair#GO:0045739;negative regulation of biological process#GO:0048519;regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA metabolic process#GO:0051052;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;regulation of signaling#GO:0023051;regulation of apoptotic signaling pathway#GO:2001233;regulation of DNA repair#GO:0006282;regulation of biological process#GO:0050789;negative regulation of extrinsic apoptotic signaling pathway#GO:2001237;positive regulation of response to stimulus#GO:0048584;cell differentiation#GO:0030154;regulation of cellular response to stress#GO:0080135;positive regulation of metabolic process#GO:0009893;negative regulation of programmed cell death#GO:0043069;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;regulation of signal transduction#GO:0009966;positive regulation of biological process#GO:0048518;negative regulation of cell communication#GO:0010648;negative regulation of cellular process#GO:0048523;regulation of programmed cell death#GO:0043067;cellular developmental process#GO:0048869;regulation of cell communication#GO:0010646;regulation of apoptotic process#GO:0042981;negative regulation of response to stimulus#GO:0048585;negative regulation of apoptotic signaling pathway#GO:2001234;negative regulation of signaling#GO:0023057;regulation of extrinsic apoptotic signaling pathway#GO:2001236;regulation of response to stress#GO:0080134;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;negative regulation of apoptotic process#GO:0043066;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;regulation of primary metabolic process#GO:0080090;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG185616|UniProtKB=T1FN16 T1FN16 20210215 PTHR10476:SF4 CHARGED MULTIVESICULAR BODY PROTEIN CHARGED MULTIVESICULAR BODY PROTEIN 2A endosomal transport#GO:0016197;cellular localization#GO:0051641;macromolecule localization#GO:0033036;vacuolar transport#GO:0007034;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;late endosome to vacuole transport#GO:0045324;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;endosome transport via multivesicular body sorting pathway#GO:0032509;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endosome membrane#GO:0010008;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG154931|UniProtKB=T1ELG4 T1ELG4 20197414 PTHR43319:SF3 BETA-LACTAMASE-RELATED BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN serine protease#PC00203 HELRO|EnsemblGenome=HelroG194900|UniProtKB=T1FWJ6 T1FWJ6 20213191 PTHR16062:SF19 SWI/SNF-RELATED PROTEIN POLYBROMO-1 protein-containing complex binding#GO:0044877;binding#GO:0005488;chromatin binding#GO:0003682 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;protein-DNA complex organization#GO:0071824;RNA metabolic process#GO:0016070;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;transcription elongation by RNA polymerase II#GO:0006368;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;heterocycle metabolic process#GO:0046483;DNA-templated transcription elongation#GO:0006354;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;chromatin organization#GO:0006325;aromatic compound biosynthetic process#GO:0019438;chromatin remodeling#GO:0006338;transcription by RNA polymerase II#GO:0006366 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;ATPase complex#GO:1904949;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG83205|UniProtKB=T1G520 T1G520 20216168 PTHR19338:SF7 TRANSLOCASE OF INNER MITOCHONDRIAL MEMBRANE 13 HOMOLOG MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8 B HELRO|EnsemblGenome=HelroG178094|UniProtKB=T1FCQ4 T1FCQ4 20206603 PTHR47763:SF1 ALPHA-PROTEIN KINASE VWKA DUF659 DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-serine modification#GO:0018209;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG171746|UniProtKB=T1F4L5 T1F4L5 20203764 PTHR19303:SF71 TRANSPOSON ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG190410|UniProtKB=T1FRZ0 T1FRZ0 20211587 PTHR13516:SF4 RIBONUCLEASE P SUBUNIT P25 FI09323P nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG62664|UniProtKB=T1FX33 T1FX33 20213381 PTHR10574:SF197 NETRIN/LAMININ-RELATED LAMININ SUBUNIT BETA-1 ISOFORM X1 neuron projection guidance#GO:0097485;cellular component biogenesis#GO:0044085;neurogenesis#GO:0022008;cell projection organization#GO:0030030;animal organ development#GO:0048513;developmental process#GO:0032502;substrate adhesion-dependent cell spreading#GO:0034446;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;extracellular matrix organization#GO:0030198;cellular anatomical entity morphogenesis#GO:0032989;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;external encapsulating structure organization#GO:0045229;neuron differentiation#GO:0030182;axonogenesis#GO:0007409;plasma membrane bounded cell projection morphogenesis#GO:0120039;cellular developmental process#GO:0048869;cellular component assembly#GO:0022607;multicellular organism development#GO:0007275;cell morphogenesis#GO:0000902;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cell motility#GO:0048870;cell-substrate adhesion#GO:0031589;cellular process#GO:0009987;tissue development#GO:0009888;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;extracellular structure organization#GO:0043062;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure development#GO:0048856;animal organ morphogenesis#GO:0009887;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;cell migration#GO:0016477 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;collagen-containing extracellular matrix#GO:0062023;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;basement membrane#GO:0005604 extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG166388|UniProtKB=T1EY29 T1EY29 20201479 PTHR11480:SF3 SAPOSIN-RELATED BCDNA.GH08312 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG67464|UniProtKB=T1FZ13 T1FZ13 20214061 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG188137|UniProtKB=T1FPP1 T1FPP1 20210788 PTHR45760:SF2 FI19922P1-RELATED FI19922P1-RELATED localization#GO:0051179;establishment of localization#GO:0051234;transport#GO:0006810 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG186524|UniProtKB=T1FP05 T1FP05 20210552 PTHR38537:SF8 JITTERBUG, ISOFORM N FILAMIN-A HELRO|EnsemblGenome=HelroG163427|UniProtKB=T1EU12 T1EU12 20200062 PTHR46109:SF1 PROTEIN LIN-28 PROTEIN LIN-28 HOMOLOG nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;RNA metabolic process#GO:0016070;regulatory ncRNA processing#GO:0070918;RNA processing#GO:0006396;gene expression#GO:0010467;pre-miRNA processing#GO:0031054;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;regulatory ncRNA-mediated gene silencing#GO:0031047;miRNA processing#GO:0035196;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG179894|UniProtKB=T1FF84 T1FF84 20207483 PTHR31004:SF1 TRANSMEMBRANE PROTEIN 79 TRANSMEMBRANE PROTEIN 79 localization#GO:0051179;regulated exocytosis#GO:0045055;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;export from cell#GO:0140352;secretion by cell#GO:0032940 bounding membrane of organelle#GO:0098588;trans-Golgi network#GO:0005802;lytic vacuole membrane#GO:0098852;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;vacuolar membrane#GO:0005774;vacuole#GO:0005773;trans-Golgi network membrane#GO:0032588;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;lytic vacuole#GO:0000323;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;lysosomal membrane#GO:0005765;lysosome#GO:0005764;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791 HELRO|EnsemblGenome=HelroG98141|UniProtKB=T1G9L0 T1G9L0 20217756 PTHR24356:SF184 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE TRICORNERED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG144970|UniProtKB=T1EJH7 T1EJH7 20196727 PTHR11467:SF36 HISTONE H1 HISTONE 24-RELATED nucleosome binding#GO:0031491;nucleic acid binding#GO:0003676;chromatin DNA binding#GO:0031490;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;protein-containing complex binding#GO:0044877 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA metabolic process#GO:0051052;chromosome condensation#GO:0030261;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;cellular process#GO:0009987;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;regulation of macromolecule metabolic process#GO:0060255;organelle organization#GO:0006996;chromosome organization#GO:0051276;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA recombination#GO:0045910;negative regulation of DNA metabolic process#GO:0051053;regulation of DNA recombination#GO:0000018;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG168356|UniProtKB=T1F0G5 T1F0G5 20202315 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG152742|UniProtKB=T1EKW5 T1EKW5 20197215 PTHR24637:SF388 COLLAGEN NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164394|UniProtKB=T1EVD5 T1EVD5 20200535 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166504|UniProtKB=T1EY68 T1EY68 20201518 PTHR13542:SF0 LSM12 HOMOLOG PROTEIN LSM12 HELRO|EnsemblGenome=HelroG82008|UniProtKB=T1G4L8 T1G4L8 20216016 PTHR13976:SF25 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED RNA-BINDING PROTEIN FUSILLI nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nitrogen compound metabolic process#GO:0051171;regulation of biosynthetic process#GO:0009889;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG169214|UniProtKB=T1F1L1 T1F1L1 20202711 PTHR20956:SF12 HEH2P FLYWCH-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174420|UniProtKB=T1F839 T1F839 20204988 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG116629|UniProtKB=T1EGG7 T1EGG7 20195669 PTHR19134:SF562 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE PROTEIN-TYROSINE-PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG182704|UniProtKB=T1FIL9 T1FIL9 20208668 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180404|UniProtKB=T1FFV9 T1FFV9 20207708 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG76160|UniProtKB=T1G2F9 T1G2F9 20215257 PTHR12022:SF0 UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN CYTOCHROME B-C1 COMPLEX SUBUNIT 7 mitochondrial ATP synthesis coupled electron transport#GO:0042775;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;respiratory electron transport chain#GO:0022904;aerobic electron transport chain#GO:0019646;oxidative phosphorylation#GO:0006119;generation of precursor metabolites and energy#GO:0006091;electron transport chain#GO:0022900;ATP synthesis coupled electron transport#GO:0042773;cellular metabolic process#GO:0044237;mitochondrial electron transport, ubiquinol to cytochrome c#GO:0006122;cellular process#GO:0009987;energy derivation by oxidation of organic compounds#GO:0015980;metabolic process#GO:0008152 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;cytochrome complex#GO:0070069;respiratory chain complex#GO:0098803;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transporter complex#GO:1990351;oxidoreductase complex#GO:1990204;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;respirasome#GO:0070469;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;mitochondrial respirasome#GO:0005746;transmembrane transporter complex#GO:1902495;inner mitochondrial membrane protein complex#GO:0098800;mitochondrial respiratory chain complex III#GO:0005750;membrane-bounded organelle#GO:0043227;mitochondrial protein-containing complex#GO:0098798 reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG186040|UniProtKB=T1FNK9 T1FNK9 20210406 PTHR45721:SF12 LAMIN DM0-RELATED INTERMEDIATE FILAMENT PROTEIN IFA-1 structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;nuclear migration#GO:0007097;cellular localization#GO:0051641;negative regulation of biological process#GO:0048519;protein-DNA complex organization#GO:0071824;organelle localization#GO:0051640;macromolecule localization#GO:0033036;membrane organization#GO:0061024;transport#GO:0006810;protein localization to nucleus#GO:0034504;nucleus organization#GO:0006997;endomembrane system organization#GO:0010256;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;protein localization to organelle#GO:0033365;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;establishment of organelle localization#GO:0051656;negative regulation of cellular process#GO:0048523;localization within membrane#GO:0051668;negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;cellular process#GO:0009987;negative regulation of gene expression, epigenetic#GO:0045814;epigenetic regulation of gene expression#GO:0040029;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular macromolecule localization#GO:0070727;heterochromatin organization#GO:0070828;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;chromatin organization#GO:0006325;intracellular transport#GO:0046907;nuclear envelope organization#GO:0006998;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323;protein-containing complex localization#GO:0031503 membrane-enclosed lumen#GO:0031974;envelope#GO:0031975;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;nuclear periphery#GO:0034399;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981 HELRO|EnsemblGenome=HelroG110162|UniProtKB=T1EF01 T1EF01 20195153 PTHR10052:SF1 60S RIBOSOMAL PROTEIN L18A LARGE RIBOSOMAL SUBUNIT PROTEIN EL20 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG104535|UniProtKB=T1EDM2 T1EDM2 20194674 PTHR47020:SF1 HILLARIN HILLARIN HELRO|EnsemblGenome=HelroG185405|UniProtKB=T1FMR9 T1FMR9 20210118 PTHR10443:SF12 MICROSOMAL DIPEPTIDASE DIPEPTIDASE protease#PC00190 HELRO|EnsemblGenome=HelroG188674|UniProtKB=T1FQ85 T1FQ85 20210982 PTHR21461:SF69 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 glycosylation#GO:0070085;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG104934|UniProtKB=T1EDP2 T1EDP2 20194694 PTHR11920:SF494 GUANYLYL CYCLASE ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2 adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 Gonadotropin-releasing hormone receptor pathway#P06664>Npr2#P06796;Endothelin signaling pathway#P00019>Guanylate cyclase#P00581 HELRO|EnsemblGenome=HelroG168974|UniProtKB=T1F175 T1F175 20202575 PTHR24200:SF11 TOUCAN, ISOFORM A TOUCAN, ISOFORM A HELRO|EnsemblGenome=HelroG94513|UniProtKB=T1G915 T1G915 20217562 PTHR13803:SF4 SEC24-RELATED PROTEIN SECRETORY 24CD, ISOFORM C cation binding#GO:0043169;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;binding#GO:0005488;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;protein binding#GO:0005515;ion binding#GO:0043167;SNARE binding#GO:0000149 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;membrane organization#GO:0061024;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;vesicle budding from membrane#GO:0006900;organelle organization#GO:0006996;COPII-coated vesicle budding#GO:0090114;establishment of localization in cell#GO:0051649;vesicle organization#GO:0016050;intracellular transport#GO:0046907 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;ER to Golgi transport vesicle membrane#GO:0012507;endoplasmic reticulum exit site#GO:0070971;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;vesicle coat#GO:0030120;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;transport vesicle membrane#GO:0030658;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane coat#GO:0030117;coated vesicle membrane#GO:0030662;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;coated membrane#GO:0048475;cytoplasmic vesicle membrane#GO:0030659;endoplasmic reticulum#GO:0005783 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG63151|UniProtKB=T1FXB6 T1FXB6 20213464 PTHR24034:SF204 EGF-LIKE DOMAIN-CONTAINING PROTEIN ADHESION G PROTEIN-COUPLED RECEPTOR E1 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG173110|UniProtKB=T1F6D4 T1F6D4 20204383 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190347|UniProtKB=T1FRX4 T1FRX4 20211571 PTHR14379:SF3 LIMKAIN B LKAP MEIOSIS REGULATOR AND MRNA STABILITY FACTOR 1 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG171429|UniProtKB=T1F496 T1F496 20203645 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG172731|UniProtKB=T1F5V6 T1F5V6 20204205 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171259|UniProtKB=T1F401 T1F401 20203550 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169863|UniProtKB=T1F2E0 T1F2E0 20202990 PTHR44170:SF54 PROTEIN SIDEKICK FI24025P1 cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG194482|UniProtKB=T1FW39 T1FW39 20213035 PTHR46830:SF2 TRANSFERASE, PUTATIVE-RELATED ALPHA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG116040|UniProtKB=T1EGC6 T1EGC6 20195628 PTHR11113:SF14 N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;deacetylase activity#GO:0019213;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824 carbohydrate derivative metabolic process#GO:1901135;carbohydrate derivative catabolic process#GO:1901136;amino sugar catabolic process#GO:0046348;amino sugar metabolic process#GO:0006040;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 deacetylase#PC00087;hydrolase#PC00121 N-acetylglucosamine metabolism#P02756>N-acetylglucosamine-6-phosphate deacetylase#P03036 HELRO|EnsemblGenome=HelroG111705|UniProtKB=T1EFD9 T1EFD9 20195291 PTHR14145:SF2 26S PROTESOME SUBUNIT 6 COP9 SIGNALOSOME COMPLEX SUBUNIT 1 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;COP9 signalosome#GO:0008180;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG170313|UniProtKB=T1F2W9 T1F2W9 20203168 PTHR10027:SF33 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic ion-gated channel activity#GO:0022839;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium-activated cation channel activity#GO:0005227;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG74483|UniProtKB=T1G1R8 T1G1R8 20215016 PTHR13555:SF5 C2H2 ZINC FINGER CGI-62-RELATED ZINC-FINGER OF A C2HC-TYPE C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG82832|UniProtKB=T1G4X1 T1G4X1 20216119 PTHR46161:SF1 NUCLEOSIDE DIPHOSPHATE KINASE NUCLEOSIDE DIPHOSPHATE KINASE HOMOLOG 5 nucleotide kinase#PC00172 De novo purine biosynthesis#P02738>dADP kinase#P02907;De novo purine biosynthesis#P02738>GDP kinase#P02891 HELRO|EnsemblGenome=HelroG184315|UniProtKB=T1FKZ1 T1FKZ1 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG106036|UniProtKB=T1EDZ4 T1EDZ4 20194796 PTHR12801:SF115 RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED FI18136P1-RELATED hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;exonuclease activity#GO:0004527;catalytic activity#GO:0003824 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;exoribonuclease#PC00099 DNA replication#P00017>RNase H#P00538 HELRO|EnsemblGenome=HelroG176448|UniProtKB=T1FAI4 T1FAI4 20205833 PTHR13244:SF7 ZINC FINGER MYND DOMAIN CONTAINING PROTEIN 10 ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 10 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG65462|UniProtKB=T1FY81 T1FY81 20213779 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG67827|UniProtKB=T1FZ60 T1FZ60 20214108 PTHR10114:SF0 60S RIBOSOMAL PROTEIN L36 LARGE RIBOSOMAL SUBUNIT PROTEIN EL36 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cytoplasmic translation#GO:0002181;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG63973|UniProtKB=T1FXN1 T1FXN1 20213579 PTHR16821:SF2 FRATAXIN FRATAXIN, MITOCHONDRIAL transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG187921|UniProtKB=T1FPH1 T1FPH1 20210718 PTHR16650:SF6 C21ORF13-RELATED GH21622P cilium organization#GO:0044782;cellular localization#GO:0051641;cell projection organization#GO:0030030;transport#GO:0006810;microtubule-based movement#GO:0007018;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;transport along microtubule#GO:0010970;intraciliary transport#GO:0042073;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;microtubule-based transport#GO:0099111;establishment of localization#GO:0051234;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;protein-containing complex localization#GO:0031503 axoneme#GO:0005930;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;plasma membrane bounded cell projection cytoplasm#GO:0032838;membrane-bounded organelle#GO:0043227;ciliary plasm#GO:0097014;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG178791|UniProtKB=T1FDR0 T1FDR0 20206959 PTHR24261:SF7 PLASMINOGEN-RELATED KRINGLE DOMAIN-CONTAINING PROTEIN serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG180762|UniProtKB=T1FG89 T1FG89 20207838 PTHR13198:SF4 RING FINGER PROTEIN 25 E3 UBIQUITIN-PROTEIN LIGASE RNF25 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185193|UniProtKB=T1FMH6 T1FMH6 20210025 PTHR12866:SF2 UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3 UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3 ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;macroautophagy#GO:0016236;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;autophagy of mitochondrion#GO:0000422;cellular process#GO:0009987;organelle disassembly#GO:1903008;organelle assembly#GO:0070925;process utilizing autophagic mechanism#GO:0061919;cellular component organization or biogenesis#GO:0071840;vacuole organization#GO:0007033;cellular component disassembly#GO:0022411;organelle organization#GO:0006996;autophagosome assembly#GO:0000045;catabolic process#GO:0009056;mitochondrion organization#GO:0007005;autophagy#GO:0006914;metabolic process#GO:0008152;cellular catabolic process#GO:0044248 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;phagophore assembly site#GO:0000407;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG65397|UniProtKB=T1FY73 T1FY73 20213771 PTHR12888:SF0 PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12 PEROXISOME ASSEMBLY PROTEIN 12 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824 cellular localization#GO:0051641;intracellular protein transmembrane transport#GO:0065002;macromolecule localization#GO:0033036;macromolecule modification#GO:0043412;protein import into peroxisome matrix#GO:0016558;transport#GO:0006810;protein transmembrane transport#GO:0071806;nitrogen compound transport#GO:0071705;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein transmembrane import into intracellular organelle#GO:0044743;establishment of protein localization#GO:0045184;organic substance transport#GO:0071702;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;protein localization to organelle#GO:0033365;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;transmembrane transport#GO:0055085;macromolecule metabolic process#GO:0043170;protein monoubiquitination#GO:0006513;organonitrogen compound metabolic process#GO:1901564;establishment of protein localization to organelle#GO:0072594;cellular component organization#GO:0016043;cellular process#GO:0009987;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;cellular macromolecule localization#GO:0070727;organelle organization#GO:0006996;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;peroxisome organization#GO:0007031 bounding membrane of organelle#GO:0098588;peroxisomal membrane#GO:0005778;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;transporter complex#GO:1990351;peroxisome#GO:0005777;membrane-bounded organelle#GO:0043227;microbody#GO:0042579;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG161460|UniProtKB=T1ERH8 T1ERH8 20199178 PTHR31796:SF2 SUZ DOMAIN-CONTAINING PROTEIN 1 SUZ DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG179421|UniProtKB=T1FEP0 T1FEP0 20207289 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG114027|UniProtKB=T1EFY3 T1EFY3 20195485 PTHR23280:SF21 4.1 G PROTEIN PROTEIN 4.1 HOMOLOG cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG90476|UniProtKB=T1G7R9 T1G7R9 20217116 PTHR11705:SF91 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B FI01817P-RELATED metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metallocarboxypeptidase activity#GO:0004181;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;carboxypeptidase activity#GO:0004180 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG167352|UniProtKB=T1EZA7 T1EZA7 20201907 PTHR45713:SF15 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173601|UniProtKB=T1F707 T1F707 20204606 PTHR33604:SF3 OSJNBA0004B13.7 PROTEIN OSJNBA0004B13.7 PROTEIN HELRO|EnsemblGenome=HelroG172748|UniProtKB=T1F5W5 T1F5W5 20204214 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183493|UniProtKB=T1FJR3 T1FJR3 20209062 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178825|UniProtKB=T1FDS7 T1FDS7 20206976 PTHR23034:SF2 GLUTAMATE-RICH PROTEIN 3 GLUTAMATE-RICH PROTEIN 3 HELRO|EnsemblGenome=HelroG120724|UniProtKB=T1EGQ4 T1EGQ4 20195754 PTHR43918:SF12 ACETYLCHOLINESTERASE ACETYLCHOLINESTERASE 1 hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;extracellular space#GO:0005615;membrane#GO:0016020;extracellular region#GO:0005576;plasma membrane#GO:0005886 esterase#PC00097;hydrolase#PC00121 Nicotinic acetylcholine receptor signaling pathway#P00044>AChE#P01093;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>AChE#P01067;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>AChE#P01080 HELRO|EnsemblGenome=HelroG188361|UniProtKB=T1FPX2 T1FPX2 20210869 PTHR14215:SF0 PROTEIN OF UNKNOWN FUNCTION DUF729 WH2 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159271|UniProtKB=T1ENT3 T1ENT3 20198233 PTHR10504:SF131 BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED BPI2 DOMAIN-CONTAINING PROTEIN defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG184600|UniProtKB=T1FLK0 T1FLK0 20209699 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186317|UniProtKB=T1FNY5 T1FNY5 20210532 PTHR11662:SF455 SOLUTE CARRIER FAMILY 17 GH23975P transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810;monoatomic anion transport#GO:0006820 cellular anatomical entity#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG113093|UniProtKB=T1EFQ2 T1EFQ2 20195404 PTHR10943:SF1 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 peptidase complex#GO:1905368;proteasome accessory complex#GO:0022624;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;proteasome regulatory particle#GO:0005838;catalytic complex#GO:1902494;proteasome complex#GO:0000502;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;endopeptidase complex#GO:1905369;membrane-bounded organelle#GO:0043227 protease#PC00190;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG163420|UniProtKB=T1EU09 T1EU09 20200059 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG70936|UniProtKB=T1G0E5 T1G0E5 20214543 PTHR13046:SF0 PROTEASE U48 CAAX PRENYL PROTEASE RCE1 CAAX PRENYL PROTEASE 2 hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG173379|UniProtKB=T1F6R0 T1F6R0 20204509 PTHR32055:SF1 INTEGRIN BETA-1-BINDING PROTEIN 1 INTEGRIN BETA-1-BINDING PROTEIN 1 cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;integrin binding#GO:0005178;binding#GO:0005488;signaling receptor binding#GO:0005102 regulation of biological process#GO:0050789;regulation of cell-matrix adhesion#GO:0001952;negative regulation of biological process#GO:0048519;regulation of cellular component biogenesis#GO:0044087;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cellular component organization#GO:0051128;regulation of cell junction assembly#GO:1901888;negative regulation of cellular component organization#GO:0051129;regulation of cell adhesion#GO:0030155;negative regulation of cellular process#GO:0048523;regulation of cell-substrate adhesion#GO:0010810;negative regulation of cell adhesion#GO:0007162 intracellular non-membrane-bounded organelle#GO:0043232;cell leading edge#GO:0031252;non-membrane-bounded organelle#GO:0043228;lamellipodium#GO:0030027;ruffle#GO:0001726;cell projection#GO:0042995;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG165272|UniProtKB=T1EWI9 T1EWI9 20200939 PTHR19139:SF199 AQUAPORIN TRANSPORTER MIP17260P cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG172364|UniProtKB=T1F584 T1F584 20203983 PTHR13475:SF3 NEUGRIN NEUGRIN HELRO|EnsemblGenome=HelroG115438|UniProtKB=T1EG81 T1EG81 20195583 PTHR16160:SF13 FERMITIN 2-RELATED FERMITIN 2-RELATED cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;integrin binding#GO:0005178;binding#GO:0005488;signaling receptor binding#GO:0005102 cell adhesion#GO:0007155;cellular process#GO:0009987;cell-matrix adhesion#GO:0007160;cell-substrate adhesion#GO:0031589 cell junction#GO:0030054;cell-substrate junction#GO:0030055;cellular anatomical entity#GO:0110165;anchoring junction#GO:0070161 HELRO|EnsemblGenome=HelroG189414|UniProtKB=T1FR15 T1FR15 20211262 PTHR18966:SF422 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED signaling receptor activity#GO:0038023;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;ligand-gated channel activity#GO:0022834 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019 HELRO|EnsemblGenome=HelroG193029|UniProtKB=T1FUJ5 T1FUJ5 20212491 PTHR31797:SF6 EXTRACELLULAR MATRIX PROTEIN A-RELATED CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG156566|UniProtKB=T1ELY3 T1ELY3 20197583 PTHR10615:SF219 HISTONE ACETYLTRANSFERASE HISTONE ACETYLTRANSFERASE KAT5 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 Alzheimer disease-presenilin pathway#P00004>Tip60#P00137;Alzheimer disease-amyloid secretase pathway#P00003>Tip60#P00093 HELRO|EnsemblGenome=HelroG158977|UniProtKB=T1ENG1 T1ENG1 20198111 PTHR46674:SF1 INACTIVE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP6 INACTIVE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP6 chaperone#PC00072 HELRO|EnsemblGenome=HelroG173784|UniProtKB=T1F781 T1F781 20204680 PTHR12374:SF20 TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED TRANSCRIPTIONAL ADAPTER 2-ALPHA molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;binding#GO:0005488;chromatin binding#GO:0003682;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;protein-containing complex binding#GO:0044877 protein-DNA complex organization#GO:0071824;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;cellular component organization#GO:0016043;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG88074|UniProtKB=T1G6Y1 T1G6Y1 20216828 PTHR24107:SF20 YNEIN REGULATORY COMPLEX SUBUNIT 5 DYNEIN REGULATORY COMPLEX SUBUNIT 5 non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG172361|UniProtKB=T1F582 T1F582 20203981 PTHR19960:SF11 TEKTIN TEKTIN cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cilium or flagellum-dependent cell motility#GO:0001539;cell motility#GO:0048870;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;cilium movement involved in cell motility#GO:0060294;cilium movement#GO:0003341;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cilium-dependent cell motility#GO:0060285;microtubule-based process#GO:0007017;organelle organization#GO:0006996;plasma membrane bounded cell projection assembly#GO:0120031 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG68442|UniProtKB=T1FZE8 T1FZE8 20214196 PTHR24416:SF614 TYROSINE-PROTEIN KINASE RECEPTOR PROTEIN KINASE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;regulation of cellular component organization#GO:0051128;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;regulation of plasma membrane bounded cell projection organization#GO:0120035;cell communication#GO:0007154;cellular process#GO:0009987;regulation of neuron projection development#GO:0010975;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;regulation of cell projection organization#GO:0031344;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG193938|UniProtKB=T1FVH8 T1FVH8 20212824 PTHR12280:SF20 PANTOTHENATE KINASE 4'-PHOSPHOPANTETHEINE PHOSPHATASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 kinase#PC00137 Coenzyme A biosynthesis#P02736>Pantothenate kinase#P02885 HELRO|EnsemblGenome=HelroG191670|UniProtKB=T1FT73 T1FT73 20212020 PTHR16284:SF13 PROTEIN CDV3 HOMOLOG PROTEIN CDV3 HOMOLOG cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG170901|UniProtKB=T1F3K6 T1F3K6 20203405 PTHR24104:SF57 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED BEE-MILK PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG96469|UniProtKB=T1G9C3 T1G9C3 20217670 PTHR11616:SF321 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;organic acid:sodium symporter activity#GO:0005343;organic acid transmembrane transporter activity#GO:0005342;symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;organic anion transmembrane transporter activity#GO:0008514;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;amino acid:sodium symporter activity#GO:0005283;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;amino acid transmembrane transporter activity#GO:0015171;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;organic anion transport#GO:0015711;amino acid transport#GO:0006865;organic acid transport#GO:0015849;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;nitrogen compound transport#GO:0071705;carboxylic acid transport#GO:0046942;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;amino acid import across plasma membrane#GO:0089718;carboxylic acid transmembrane transport#GO:1905039;localization#GO:0051179;organic substance transport#GO:0071702;import across plasma membrane#GO:0098739;amino acid transmembrane transport#GO:0003333;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transport#GO:0006812;organic acid transmembrane transport#GO:1903825;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>CHT1#P01084 HELRO|EnsemblGenome=HelroG182714|UniProtKB=T1FIM7 T1FIM7 20208676 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177333|UniProtKB=T1FBI6 T1FBI6 20206185 PTHR10985:SF77 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED GH26014P sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of multicellular organismal process#GO:0051239;regulation of cell development#GO:0060284;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regionalization#GO:0003002;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of RNA biosynthetic process#GO:2001141;regulation of multicellular organismal development#GO:2000026;regulation of cell differentiation#GO:0045595;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of neurogenesis#GO:0050767;regulation of macromolecule metabolic process#GO:0060255;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;regulation of nervous system development#GO:0051960;biological regulation#GO:0065007;anterior/posterior pattern specification#GO:0009952;multicellular organismal process#GO:0032501;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;pattern specification process#GO:0007389;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG171760|UniProtKB=T1F4M0 T1F4M0 20203769 PTHR45749:SF21 FAMILY NOT NAMED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG90783|UniProtKB=T1G7W3 T1G7W3 20217160 PTHR13117:SF5 ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED PROTEIN RFT1 HOMOLOG macromolecule localization#GO:0033036;membrane organization#GO:0061024;transport#GO:0006810;cellular component organization#GO:0016043;regulation of membrane lipid distribution#GO:0097035;cellular process#GO:0009987;lipid transport#GO:0006869;localization#GO:0051179;organic substance transport#GO:0071702;cellular component organization or biogenesis#GO:0071840;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;lipid translocation#GO:0034204;biological regulation#GO:0065007;lipid localization#GO:0010876;carbohydrate derivative transport#GO:1901264 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG161551|UniProtKB=T1ERM0 T1ERM0 20199220 PTHR15712:SF23 ARMADILLO REPEAT CONTAINING PROTEIN ARMADILLO REPEAT CONTAINING 10 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG184021|UniProtKB=T1FKF9 T1FKF9 20209308 PTHR22906:SF21 PROPERDIN SEMA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177690|UniProtKB=T1FC32 T1FC32 20206381 PTHR10740:SF14 TRANSFORMING GROWTH FACTOR ALPHA EGF-LIKE DOMAIN-CONTAINING PROTEIN signal transduction#GO:0007165;epidermal growth factor receptor signaling pathway#GO:0007173;regulation of mitotic nuclear division#GO:0007088;cellular response to stimulus#GO:0051716;positive regulation of organelle organization#GO:0010638;regulation of nuclear division#GO:0051783;regulation of cell population proliferation#GO:0042127;regulation of organelle organization#GO:0033043;positive regulation of mitotic nuclear division#GO:0045840;positive regulation of cell population proliferation#GO:0008284;positive regulation of cell cycle#GO:0045787;regulation of cellular component organization#GO:0051128;cell communication#GO:0007154;cellular process#GO:0009987;ERBB signaling pathway#GO:0038127;regulation of cell cycle process#GO:0010564;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of cell cycle process#GO:0090068;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;regulation of cell cycle#GO:0051726;regulation of mitotic cell cycle#GO:0007346;signaling#GO:0023052;positive regulation of biological process#GO:0048518;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169 growth factor#PC00112 HELRO|EnsemblGenome=HelroG189247|UniProtKB=T1FQV2 T1FQV2 20211199 PTHR46584:SF1 HMG DOMAIN-CONTAINING PROTEIN 4 HMG DOMAIN-CONTAINING PROTEIN 4 HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG108537|UniProtKB=T1EEK0 T1EEK0 20195002 PTHR45622:SF60 UBIQUITIN-PROTEIN LIGASE E3A-RELATED UBIQUITIN-PROTEIN LIGASE E3A transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E3#P01490 HELRO|EnsemblGenome=HelroG189224|UniProtKB=T1FQT7 T1FQT7 20211184 PTHR22901:SF0 SIALATE O-ACETYLESTERASE SIALATE O-ACETYLESTERASE hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 carbohydrate metabolic process#GO:0005975;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238;metabolic process#GO:0008152 esterase#PC00097 HELRO|EnsemblGenome=HelroG102672|UniProtKB=T1EDA9 T1EDA9 20194561 PTHR46028:SF2 KYNURENINE 3-MONOOXYGENASE KYNURENINE 3-MONOOXYGENASE oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen#GO:0016709 cellular aromatic compound metabolic process#GO:0006725;oxoacid metabolic process#GO:0043436;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;alpha-amino acid metabolic process#GO:1901605;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG186151|UniProtKB=T1FNQ6 T1FNQ6 20210453 PTHR45635:SF14 ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED ADP_ATP TRANSLOCASE transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG194910|UniProtKB=T1FWJ9 T1FWJ9 20213194 PTHR11232:SF17 PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER CAPON-LIKE PROTEIN enzyme binding#GO:0019899;protein binding#GO:0005515;binding#GO:0005488 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG67268|UniProtKB=T1FYZ1 T1FYZ1 20214039 PTHR24418:SF458 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE CSK protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 non-receptor tyrosine protein kinase#PC00168 Integrin signalling pathway#P00034>Csk#P00913;Parkinson disease#P00049>Src kinase#P01230;CCKR signaling map#P06959>CSK#P07072;T cell activation#P00053>Csk#P01304 HELRO|EnsemblGenome=HelroG70657|UniProtKB=T1G0A0 T1G0A0 20214498 PTHR43146:SF1 CANCER-RELATED NUCLEOSIDE-TRIPHOSPHATASE CANCER-RELATED NUCLEOSIDE-TRIPHOSPHATASE phosphatase#PC00181 HELRO|EnsemblGenome=HelroG171808|UniProtKB=T1F4P9 T1F4P9 20203798 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG189876|UniProtKB=T1FRF9 T1FRF9 20211406 PTHR46538:SF3 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG154313|UniProtKB=T1ELE4 T1ELE4 20197394 PTHR23409:SF18 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 reductase#PC00198;oxidoreductase#PC00176 De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>CDP Reductase#P02915;De novo purine biosynthesis#P02738>ADP reductase#P02902;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>UDP reductase#P02921;De novo purine biosynthesis#P02738>GDP reductase#P02909 HELRO|EnsemblGenome=HelroG66985|UniProtKB=T1FYU8 T1FYU8 20213996 PTHR45703:SF22 DYNEIN HEAVY CHAIN DYNEIN CYTOPLASMIC 2 HEAVY CHAIN 1 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG114559|UniProtKB=T1EG29 T1EG29 20195531 PTHR11390:SF21 PROKARYOTIC DNA TOPOISOMERASE DNA TOPOISOMERASE 3-ALPHA catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on DNA#GO:0140097;isomerase activity#GO:0016853;catalytic activity#GO:0003824 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;DNA conformation change#GO:0071103;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;DNA damage response#GO:0006974;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;organelle organization#GO:0006996;chromosome organization#GO:0051276;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG141834|UniProtKB=T1EJ44 T1EJ44 20196594 PTHR24409:SF418 ZINC FINGER PROTEIN 142 SI:CH73-221F6.1 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG188672|UniProtKB=T1FQ84 T1FQ84 20210981 PTHR10826:SF1 COMPLEMENT COMPONENT 1 COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL complement component#PC00078 HELRO|EnsemblGenome=HelroG155684|UniProtKB=T1ELK4 T1ELK4 20197454 PTHR24073:SF858 DRAB5-RELATED DRAB5 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 localization#GO:0051179;organic substance transport#GO:0071702;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;protein transport#GO:0015031;nitrogen compound transport#GO:0071705;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG179644|UniProtKB=T1FEZ4 T1FEZ4 20207393 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG105292|UniProtKB=T1EDT3 T1EDT3 20194735 PTHR11647:SF1 HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER COLLAPSIN RESPONSE MEDIATOR PROTEIN metabolite interconversion enzyme#PC00262;hydrolase#PC00121 Axon guidance mediated by semaphorins#P00007>CRMP#P00339;Pyrimidine Metabolism#P02771>Dihydropyrimidinase#P03125 HELRO|EnsemblGenome=HelroG112211|UniProtKB=T1EFH8 T1EFH8 20195330 PTHR24343:SF466 SERINE/THREONINE KINASE AMP-ACTIVATED PROTEIN KINASE ALPHA SUBUNIT, ISOFORM A transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG161373|UniProtKB=T1ERE8 T1ERE8 20199148 PTHR24230:SF158 G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;neuropeptide signaling pathway#GO:0007218;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG112262|UniProtKB=T1EFI2 T1EFI2 20195334 PTHR22880:SF225 FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED protein binding#GO:0005515;histone binding#GO:0042393;binding#GO:0005488;modification-dependent protein binding#GO:0140030 protein-DNA complex organization#GO:0071824;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;cellular component organization#GO:0016043;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG154121|UniProtKB=T1ELD8 T1ELD8 20197388 PTHR21569:SF1 RIBOSOMAL PROTEIN S9 SMALL RIBOSOMAL SUBUNIT PROTEIN US9M structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;small ribosomal subunit#GO:0015935;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG146843|UniProtKB=T1EJU9 T1EJU9 20196849 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG111195|UniProtKB=T1EF94 T1EF94 20195246 PTHR10574:SF365 NETRIN/LAMININ-RELATED NETRIN-A-RELATED neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;cell projection organization#GO:0030030;animal organ development#GO:0048513;developmental process#GO:0032502;dendrite development#GO:0016358;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;axonogenesis#GO:0007409;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization#GO:0016043;cell morphogenesis#GO:0000902;cellular process#GO:0009987;tissue development#GO:0009888;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;motor neuron axon guidance#GO:0008045;anatomical structure development#GO:0048856;animal organ morphogenesis#GO:0009887;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;collagen-containing extracellular matrix#GO:0062023;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;basement membrane#GO:0005604 extracellular matrix protein#PC00102 Axon guidance mediated by netrin#P00009>Netrin#P00357;Axon guidance mediated by Slit/Robo#P00008>Netrin#P00344 HELRO|EnsemblGenome=HelroG193067|UniProtKB=T1FUL2 T1FUL2 20212508 PTHR19282:SF452 TETRASPANIN LD03691P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG73187|UniProtKB=T1G1B4 T1G1B4 20214862 PTHR12716:SF8 TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA basal RNA polymerase II transcription machinery binding#GO:0001099;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;basal transcription machinery binding#GO:0001098;transcription factor binding#GO:0008134;binding#GO:0005488 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;transcription initiation at RNA polymerase II promoter#GO:0006367;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nucleobase-containing compound biosynthetic process#GO:0034654;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase II, holoenzyme#GO:0016591;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;transcription regulator complex#GO:0005667;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;general transcription factor#PC00259 General transcription regulation#P00023>TFIIE#P00666;Transcription regulation by bZIP transcription factor#P00055>TFIIEbeta#P01386;Transcription regulation by bZIP transcription factor#P00055>TFIIE#P01395;General transcription regulation#P00023>TFIIEbeta#P00659 HELRO|EnsemblGenome=HelroG157302|UniProtKB=T1EM91 T1EM91 20197691 PTHR23290:SF0 RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5 RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5 transferase activity#GO:0016740;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG158566|UniProtKB=T1EMY3 T1EMY3 20197933 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG184517|UniProtKB=T1FLD6 T1FLD6 20209635 PTHR23512:SF5 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG191365|UniProtKB=T1FSX3 T1FSX3 20211920 PTHR21481:SF0 PROTEIN CLEC16A PROTEIN CLEC16A endosomal transport#GO:0016197;cellular localization#GO:0051641;regulation of catabolic process#GO:0009894;vacuolar transport#GO:0007034;regulation of autophagy#GO:0010506;regulation of organelle organization#GO:0033043;transport#GO:0006810;vesicle-mediated transport#GO:0016192;regulation of cellular component organization#GO:0051128;regulation of protein-containing complex disassembly#GO:0043244;regulation of macroautophagy#GO:0016241;regulation of cellular catabolic process#GO:0031329;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;regulation of autophagosome maturation#GO:1901096;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;late endosome#GO:0005770;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG164067|UniProtKB=T1EUV3 T1EUV3 20200353 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG175776|UniProtKB=T1F9N1 T1F9N1 20205530 PTHR10642:SF26 RIBONUCLEASE H1 RIBONUCLEASE H1 catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular nitrogen compound catabolic process#GO:0044270;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic cyclic compound catabolic process#GO:1901361;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;organic substance catabolic process#GO:1901575;nucleobase-containing compound catabolic process#GO:0034655;DNA replication#GO:0006260;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;cellular catabolic process#GO:0044248 endoribonuclease#PC00094;RNA metabolism protein#PC00031 DNA replication#P00017>RNase H#P00538 HELRO|EnsemblGenome=HelroG174269|UniProtKB=T1F7X0 T1F7X0 20204919 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG181310|UniProtKB=T1FGV9 T1FGV9 20208058 PTHR31402:SF2 UPF0711 PROTEIN C18ORF21 UPF0711 PROTEIN C18ORF21 HELRO|EnsemblGenome=HelroG188449|UniProtKB=T1FQ00 T1FQ00 20210897 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG180332|UniProtKB=T1FFR6 T1FFR6 20207665 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG164759|UniProtKB=T1EVS1 T1EVS1 20200671 PTHR11422:SF10 T-CELL SURFACE GLYCOPROTEIN CD4 IG-LIKE DOMAIN-CONTAINING PROTEIN immunoglobulin receptor superfamily#PC00124 HELRO|EnsemblGenome=HelroG163210|UniProtKB=T1ETT0 T1ETT0 20199980 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG170727|UniProtKB=T1F3D1 T1F3D1 20203330 PTHR15487:SF4 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-BINDING PROTEIN ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-BINDING PROTEIN positive regulation of nitrogen compound metabolic process#GO:0051173;cellular localization#GO:0051641;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;macromolecule localization#GO:0033036;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;protein localization to nucleus#GO:0034504;positive regulation of protein modification process#GO:0031401;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of metabolic process#GO:0009893;protein localization to organelle#GO:0033365;positive regulation of biological process#GO:0048518;positive regulation of protein phosphorylation#GO:0001934;positive regulation of phosphorylation#GO:0042327;regulation of peptidyl-tyrosine phosphorylation#GO:0050730;positive regulation of peptidyl-tyrosine phosphorylation#GO:0050731;positive regulation of phosphorus metabolic process#GO:0010562;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;protein localization#GO:0008104;positive regulation of cellular process#GO:0048522;localization#GO:0051179;regulation of primary metabolic process#GO:0080090;positive regulation of tyrosine phosphorylation of STAT protein#GO:0042531;positive regulation of protein metabolic process#GO:0051247;positive regulation of phosphate metabolic process#GO:0045937;cellular macromolecule localization#GO:0070727;regulation of macromolecule metabolic process#GO:0060255;maintenance of location#GO:0051235;regulation of cellular process#GO:0050794;regulation of protein phosphorylation#GO:0001932;maintenance of location in cell#GO:0051651;biological regulation#GO:0065007;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 envelope#GO:0031975;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;mitochondrial envelope#GO:0005740;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;mitochondrial intermembrane space#GO:0005758;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG157615|UniProtKB=T1EME0 T1EME0 20197740 PTHR11461:SF372 SERINE PROTEASE INHIBITOR, SERPIN ACCESSORY GLAND PROTEIN ACP76A-RELATED extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG188955|UniProtKB=T1FQI1 T1FQI1 20211078 PTHR10075:SF100 BASIGIN RELATED FASCICLIN-2 cell adhesion molecule binding#GO:0050839;cell-cell adhesion mediator activity#GO:0098632;protein binding#GO:0005515;binding#GO:0005488 neuron projection guidance#GO:0097485;cell recognition#GO:0008037;neurogenesis#GO:0022008;cell projection organization#GO:0030030;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;axonogenesis#GO:0007409;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156;cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cell morphogenesis#GO:0000902;cellular process#GO:0009987;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure development#GO:0048856;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;axon#GO:0030424 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG178516|UniProtKB=T1FDA5 T1FDA5 20206804 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG174430|UniProtKB=T1F842 T1F842 20204991 PTHR11782:SF83 ADENOSINE/GUANOSINE DIPHOSPHATASE GUANOSINE-DIPHOSPHATASE pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;nucleoside diphosphate phosphatase activity#GO:0017110;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;nucleoside phosphate catabolic process#GO:1901292;heterocycle catabolic process#GO:0046700;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleoside diphosphate catabolic process#GO:0009134;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate catabolic process#GO:0046434;phosphate-containing compound metabolic process#GO:0006796;cellular nitrogen compound catabolic process#GO:0044270;aromatic compound catabolic process#GO:0019439;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;organic cyclic compound catabolic process#GO:1901361;catabolic process#GO:0009056;nucleoside diphosphate metabolic process#GO:0009132;organophosphate metabolic process#GO:0019637;organic substance catabolic process#GO:1901575;nucleobase-containing compound catabolic process#GO:0034655;small molecule metabolic process#GO:0044281;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248 cellular anatomical entity#GO:0110165;membrane#GO:0016020 metabolite interconversion enzyme#PC00262;phosphatase#PC00181;nucleotide phosphatase#PC00173 HELRO|EnsemblGenome=HelroG86817|UniProtKB=T1G6H2 T1G6H2 20216669 PTHR47084:SF1 SERINE PALMITOYLTRANSFERASE SMALL SUBUNIT A SERINE PALMITOYLTRANSFERASE SMALL SUBUNIT A palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;membrane lipid biosynthetic process#GO:0046467;sphingolipid metabolic process#GO:0006665;primary metabolic process#GO:0044238;ceramide metabolic process#GO:0006672;amide biosynthetic process#GO:0043604;membrane lipid metabolic process#GO:0006643;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;ceramide biosynthetic process#GO:0046513;cellular lipid metabolic process#GO:0044255;amide metabolic process#GO:0043603;sphingolipid biosynthetic process#GO:0030148;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;endoplasmic reticulum protein-containing complex#GO:0140534;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;catalytic complex#GO:1902494;transferase complex#GO:1990234;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG161228|UniProtKB=T1ER85 T1ER85 20199085 PTHR13850:SF5 PLEIOTROPHIN FAMILY MEMBER PLEIOTROPHIN_MIDKINE N-TERMINAL DOMAIN-CONTAINING PROTEIN growth factor#PC00112 HELRO|EnsemblGenome=HelroG178867|UniProtKB=T1FDU3 T1FDU3 20206992 PTHR11742:SF55 MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 carbohydrate derivative metabolic process#GO:1901135;macromolecule modification#GO:0043412;protein catabolic process#GO:0030163;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;macromolecule catabolic process#GO:0009057;response to endoplasmic reticulum stress#GO:0034976;response to oxygen-containing compound#GO:1901700;macromolecule metabolic process#GO:0043170;carbohydrate derivative catabolic process#GO:1901136;organonitrogen compound metabolic process#GO:1901564;ERAD pathway#GO:0036503;response to organonitrogen compound#GO:0010243;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;cellular response to stress#GO:0033554 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG63198|UniProtKB=T1FXC0 T1FXC0 20213468 PTHR46061:SF3 THYROTROPIN-RELEASING HORMONE RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 Thyrotropin-releasing hormone receptor signaling pathway#P04394>TRH Receptor#P04580 HELRO|EnsemblGenome=HelroG163140|UniProtKB=T1ETP9 T1ETP9 20199949 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG69872|UniProtKB=T1FZZ1 T1FZZ1 20214389 PTHR24302:SF15 CYTOCHROME P450 FAMILY 3 FATTY-ACID PEROXYGENASE oxygenase#PC00177;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG181817|UniProtKB=T1FHD4 T1FHD4 20208233 PTHR18978:SF1 GRIP-1 ASSOCIATED PROTEIN 1 GRIP1-ASSOCIATED PROTEIN 1 endosomal transport#GO:0016197;cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;regulation of synapse organization#GO:0050807;regulation of localization#GO:0032879;regulation of cellular component organization#GO:0051128;establishment of protein localization#GO:0045184;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;organic substance transport#GO:0071702;establishment of protein localization to membrane#GO:0090150;endocytic recycling#GO:0032456;regulation of transport#GO:0051049;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;neurotransmitter receptor transport to postsynaptic membrane#GO:0098969;regulation of protein transport#GO:0051223;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;regulation of protein localization#GO:0032880;protein localization to plasma membrane#GO:0072659;localization within membrane#GO:0051668;vesicle-mediated transport to the plasma membrane#GO:0098876;protein localization to synapse#GO:0035418;protein localization to membrane#GO:0072657;regulation of protein localization to membrane#GO:1905475;vesicle-mediated transport#GO:0016192;regulation of cellular localization#GO:0060341;cellular process#GO:0009987;protein localization#GO:0008104;localization#GO:0051179;protein localization to cell periphery#GO:1990778;cellular macromolecule localization#GO:0070727;regulation of cellular process#GO:0050794;protein localization to cell junction#GO:1902414;protein transport#GO:0015031;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;regulation of synapse structure or activity#GO:0050803;regulation of establishment of protein localization#GO:0070201;protein-containing complex localization#GO:0031503 bounding membrane of organelle#GO:0098588;synapse#GO:0045202;endosome#GO:0005768;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cell junction#GO:0030054;early endosome#GO:0005769;glutamatergic synapse#GO:0098978;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endosome membrane#GO:0010008;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;extrinsic component of membrane#GO:0019898;intracellular anatomical structure#GO:0005622;early endosome membrane#GO:0031901;cytoplasm#GO:0005737;endomembrane system#GO:0012505;recycling endosome#GO:0055037;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;postsynapse#GO:0098794;cytoplasmic vesicle membrane#GO:0030659 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG163959|UniProtKB=T1EUN9 T1EUN9 20200289 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG85113|UniProtKB=T1G5T0 T1G5T0 20216427 PTHR48043:SF145 EG:EG0003.4 PROTEIN-RELATED FI06409P-RELATED HELRO|EnsemblGenome=HelroG70388|UniProtKB=T1G062 T1G062 20214460 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG62061|UniProtKB=T1FWV1 T1FWV1 20213299 PTHR24068:SF159 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 T ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular process#GO:0009987;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;DNA damage response#GO:0006974;response to stress#GO:0006950;nitrogen compound metabolic process#GO:0006807;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;cellular response to stress#GO:0033554;protein modification by small protein conjugation#GO:0032446;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E2#P01491 HELRO|EnsemblGenome=HelroG86204|UniProtKB=T1G684 T1G684 20216581 PTHR10127:SF775 DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING METALLOENDOPEPTIDASE hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG179724|UniProtKB=T1FF29 T1FF29 20207428 PTHR15431:SF19 FGFR1 ONCOGENE PARTNER/LISH DOMAIN-CONTAINING PROTEIN CENTROSOMAL PROTEIN 20-RELATED organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 microtubule organizing center#GO:0005815;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;intracellular organelle#GO:0043229;centrosome#GO:0005813;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;motile cilium#GO:0031514;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cytoskeleton#GO:0005856;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG109477|UniProtKB=T1EEU1 T1EEU1 20195093 PTHR11907:SF0 AMIDOPHOSPHORIBOSYLTRANSFERASE AMIDOPHOSPHORIBOSYLTRANSFERASE transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;pentosyltransferase activity#GO:0016763;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 transferase#PC00220;metabolite interconversion enzyme#PC00262 De novo purine biosynthesis#P02738>Amidophosphoribosyl transferase#P02905 HELRO|EnsemblGenome=HelroG182688|UniProtKB=T1FIL2 T1FIL2 20208661 PTHR47027:SF23 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG75957|UniProtKB=T1G2D2 T1G2D2 20215230 PTHR11927:SF9 GALACTOSIDE 2-L-FUCOSYLTRANSFERASE L-FUCOSYLTRANSFERASE transferase activity#GO:0016740;fucosyltransferase activity#GO:0008417;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein glycosylation#GO:0006486;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycosylation#GO:0070085;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG185220|UniProtKB=T1FMI8 T1FMI8 20210037 PTHR11835:SF42 DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 organic hydroxy compound metabolic process#GO:1901615;oxoacid metabolic process#GO:0043436;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;alcohol metabolic process#GO:0006066;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;energy derivation by oxidation of organic compounds#GO:0015980;tricarboxylic acid cycle#GO:0006099;primary metabolic process#GO:0044238;secondary alcohol metabolic process#GO:1902652;carboxylic acid metabolic process#GO:0019752;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG179562|UniProtKB=T1FEV5 T1FEV5 20207354 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG108687|UniProtKB=T1EEL5 T1EEL5 20195017 PTHR12175:SF1 AD039 HT014 THIOREDOXIN FAMILY TRP26 PITH DOMAIN-CONTAINING PROTEIN 1 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG177392|UniProtKB=T1FBL9 T1FBL9 20206218 PTHR11875:SF49 TESTIS-SPECIFIC Y-ENCODED PROTEIN PROTEIN SET protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;chromatin binding#GO:0003682;histone binding#GO:0042393 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;chromosome#GO:0005694;chromatin#GO:0000785;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG184703|UniProtKB=T1FLT3 T1FLT3 20209782 PTHR12107:SF0 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT STARGAZIN (MAMMALIAN CALCIUM CHANNEL) HOMOLOG calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;voltage-gated channel activity#GO:0022832;molecular function regulator activity#GO:0098772;transporter regulator activity#GO:0141108;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;channel regulator activity#GO:0016247;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;inorganic cation transmembrane transporter activity#GO:0022890 cellular localization#GO:0051641;macromolecule localization#GO:0033036;receptor internalization#GO:0031623;system process#GO:0003008;transport#GO:0006810;regulation of signaling#GO:0023051;nitrogen compound transport#GO:0071705;regulation of localization#GO:0032879;endosome to lysosome transport#GO:0008333;lysosomal transport#GO:0007041;establishment of protein localization#GO:0045184;regulation of biological process#GO:0050789;organic substance transport#GO:0071702;regulation of transport#GO:0051049;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;regulation of molecular function#GO:0065009;regulation of signal transduction#GO:0009966;receptor-mediated endocytosis#GO:0006898;regulation of monoatomic ion transmembrane transporter activity#GO:0032412;regulation of transmembrane transporter activity#GO:0022898;protein localization to organelle#GO:0033365;regulation of transporter activity#GO:0032409;positive regulation of signaling#GO:0023056;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;positive regulation of biological process#GO:0048518;localization within membrane#GO:0051668;regulation of cell communication#GO:0010646;establishment of protein localization to vacuole#GO:0072666;regulation of transmembrane transport#GO:0034762;vacuolar transport#GO:0007034;endocytosis#GO:0006897;protein localization to vacuole#GO:0072665;vesicle-mediated transport#GO:0016192;establishment of protein localization to organelle#GO:0072594;nervous system process#GO:0050877;cell communication#GO:0007154;cellular process#GO:0009987;regulation of synaptic transmission, glutamatergic#GO:0051966;protein localization#GO:0008104;positive regulation of cellular process#GO:0048522;localization#GO:0051179;regulation of response to stimulus#GO:0048583;protein localization to lysosome#GO:0061462;cellular macromolecule localization#GO:0070727;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;positive regulation of cell communication#GO:0010647;protein transport#GO:0015031;biological regulation#GO:0065007;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;regulation of trans-synaptic signaling#GO:0099177;multicellular organismal process#GO:0032501;intracellular transport#GO:0046907;positive regulation of synaptic transmission#GO:0050806;import into cell#GO:0098657;protein-containing complex localization#GO:0031503 membrane protein complex#GO:0098796;synapse#GO:0045202;postsynaptic specialization#GO:0099572;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;plasma membrane signaling receptor complex#GO:0098802;transporter complex#GO:1990351;plasma membrane protein complex#GO:0098797;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;neuron to neuron synapse#GO:0098984;membrane#GO:0016020;synaptic membrane#GO:0097060;asymmetric synapse#GO:0032279;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;transmembrane transporter complex#GO:1902495;postsynaptic density membrane#GO:0098839;postsynaptic specialization membrane#GO:0099634;plasma membrane region#GO:0098590;postsynapse#GO:0098794;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG159244|UniProtKB=T1ENS6 T1ENS6 20198226 PTHR45857:SF4 FORMIN-LIKE PROTEIN FORMIN-LIKE PROTEIN HELRO|EnsemblGenome=HelroG194108|UniProtKB=T1FVP4 T1FVP4 20212890 PTHR13115:SF8 RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG basal RNA polymerase II transcription machinery binding#GO:0001099;RNA polymerase binding#GO:0070063;binding#GO:0005488;RNA polymerase core enzyme binding#GO:0043175;RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515;enzyme binding#GO:0019899;basal transcription machinery binding#GO:0001098 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;transcription elongation factor complex#GO:0008023;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase II, holoenzyme#GO:0016591;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;Cdc73/Paf1 complex#GO:0016593;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG81646|UniProtKB=T1G4G9 T1G4G9 20215967 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG177813|UniProtKB=T1FCB1 T1FCB1 20206460 PTHR11905:SF159 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG170422|UniProtKB=T1F313 T1F313 20203212 PTHR47633:SF11 IMMUNOGLOBULIN IG-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG107927|UniProtKB=T1EEE0 T1EEE0 20194942 PTHR24390:SF237 ZINC FINGER PROTEIN FI23536P1-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG111318|UniProtKB=T1EFA3 T1EFA3 20195255 PTHR47633:SF4 IMMUNOGLOBULIN MYOPALLADIN ISOFORM X1 HELRO|EnsemblGenome=HelroG149935|UniProtKB=T1EKD9 T1EKD9 20197039 PTHR11909:SF155 CASEIN KINASE-RELATED GILGAMESH, ISOFORM L transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 signal transduction#GO:0007165;macromolecule modification#GO:0043412;transport#GO:0006810;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;endocytosis#GO:0006897;cellular metabolic process#GO:0044237;vesicle-mediated transport#GO:0016192;organonitrogen compound metabolic process#GO:1901564;protein phosphorylation#GO:0006468;cell communication#GO:0007154;cellular process#GO:0009987;primary metabolic process#GO:0044238;localization#GO:0051179;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;import into cell#GO:0098657 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Parkinson disease#P00049>Casein kinase I#P01242 HELRO|EnsemblGenome=HelroG174541|UniProtKB=T1F885 T1F885 20205034 PTHR48043:SF145 EG:EG0003.4 PROTEIN-RELATED FI06409P-RELATED HELRO|EnsemblGenome=HelroG164578|UniProtKB=T1EVL5 T1EVL5 20200615 PTHR45901:SF3 PROTEIN CBG12474 LIPOXYGENASE HOMOLOGY DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG101733|UniProtKB=T1ED65 T1ED65 20194517 PTHR10746:SF6 50S RIBOSOMAL PROTEIN L4 LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG108977|UniProtKB=T1EEP5 T1EEP5 20195047 PTHR24035:SF141 MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 6 extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG78741|UniProtKB=T1G3F2 T1G3F2 20215600 PTHR10159:SF519 DUAL SPECIFICITY PROTEIN PHOSPHATASE DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;dephosphorylation#GO:0016311;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein phosphatase#PC00195;protein modifying enzyme#PC00260 Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG90909|UniProtKB=T1G7X8 T1G7X8 20217175 PTHR45620:SF42 PDF RECEPTOR-LIKE PROTEIN-RELATED G-PROTEIN COUPLED RECEPTOR SEB-2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG177015|UniProtKB=T1FB53 T1FB53 20206052 PTHR13217:SF13 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 TRANSMEMBRANE PROTEIN 230 HELRO|EnsemblGenome=HelroG73159|UniProtKB=T1G1B0 T1G1B0 20214858 PTHR23429:SF0 GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 cellular aromatic compound metabolic process#GO:0006725;monosaccharide metabolic process#GO:0005996;carbohydrate derivative metabolic process#GO:1901135;pyridine nucleotide metabolic process#GO:0019362;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;carbohydrate metabolic process#GO:0005975;NADP metabolic process#GO:0006739;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;organonitrogen compound metabolic process#GO:1901564;nicotinamide nucleotide metabolic process#GO:0046496;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;glucose metabolic process#GO:0006006;glucose 6-phosphate metabolic process#GO:0051156;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;hexose metabolic process#GO:0019318;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG77001|UniProtKB=T1G2S3 T1G2S3 20215371 PTHR19818:SF139 ZINC FINGER PROTEIN ZIC AND GLI PAIR-RULE PROTEIN ODD-PAIRED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG160014|UniProtKB=T1EPN7 T1EPN7 20198537 PTHR35193:SF5 MUCIN 13A, CELL SURFACE-ASSOCIATED-RELATED FLOCCULATION PROTEIN FLO11 HELRO|EnsemblGenome=HelroG105366|UniProtKB=T1EDU1 T1EDU1 20194743 PTHR47958:SF32 ATP-DEPENDENT RNA HELICASE DBP3 RNA HELICASE nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG166091|UniProtKB=T1EXR0 T1EXR0 20201360 PTHR45740:SF2 POLY [ADP-RIBOSE] POLYMERASE POLY [ADP-RIBOSE] POLYMERASE transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;pentosyltransferase activity#GO:0016763 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185642|UniProtKB=T1FN30 T1FN30 20210229 PTHR23049:SF71 MYOSIN REGULATORY LIGHT CHAIN 2 MYOSIN REGULATORY LIGHT CHAIN 1-RELATED cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;myosin binding#GO:0017022;binding#GO:0005488 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;myosin complex#GO:0016459;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG190449|UniProtKB=T1FS02 T1FS02 20211599 PTHR10742:SF410 FLAVIN MONOAMINE OXIDASE LYSINE-SPECIFIC HISTONE DEMETHYLASE 2 oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 oxidase#PC00175;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG185351|UniProtKB=T1FMP9 T1FMP9 20210098 PTHR33562:SF2 ATILLA, ISOFORM B-RELATED-RELATED PROTEIN QUIVER HELRO|EnsemblGenome=HelroG156211|UniProtKB=T1ELS8 T1ELS8 20197528 PTHR28441:SF2 PROTEIN FAM91A1 PROTEIN FAM91A1 HELRO|EnsemblGenome=HelroG114851|UniProtKB=T1EG49 T1EG49 20195551 PTHR21432:SF20 ACETYL-COA HYDROLASE-RELATED ACETYL-COA HYDROLASE metabolite interconversion enzyme#PC00262;hydrolase#PC00121 Adenine and hypoxanthine salvage pathway#P02723>Adenosine deaminase#P02811;Adenine and hypoxanthine salvage pathway#P02723>Deoxyadenosine deaminase#P02807 HELRO|EnsemblGenome=HelroG87168|UniProtKB=T1G6M7 T1G6M7 20216724 PTHR10972:SF205 OXYSTEROL-BINDING PROTEIN-RELATED OXYSTEROL-BINDING PROTEIN 1 binding#GO:0005488;organic cyclic compound binding#GO:0097159;steroid binding#GO:0005496;sterol transporter activity#GO:0015248;sterol binding#GO:0032934;lipid binding#GO:0008289;lipid transporter activity#GO:0005319;transporter activity#GO:0005215 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG154526|UniProtKB=T1ELE9 T1ELE9 20197399 PTHR10485:SF0 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17 AT05822P-RELATED protein transmembrane transporter activity#GO:0008320;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular localization#GO:0051641;transmembrane transport#GO:0055085;macromolecule localization#GO:0033036;transport#GO:0006810;protein transmembrane transport#GO:0071806;protein targeting#GO:0006605;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;protein localization to mitochondrion#GO:0070585;cellular process#GO:0009987;protein transmembrane import into intracellular organelle#GO:0044743;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;mitochondrial transport#GO:0006839;organic substance transport#GO:0071702;protein import into mitochondrial matrix#GO:0030150;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein targeting to mitochondrion#GO:0006626;establishment of protein localization to mitochondrion#GO:0072655;protein transport#GO:0015031;protein localization to organelle#GO:0033365;mitochondrial transmembrane transport#GO:1990542 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;TIM23 mitochondrial import inner membrane translocase complex#GO:0005744;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;mitochondrial protein-containing complex#GO:0098798 transporter#PC00227 HELRO|EnsemblGenome=HelroG77588|UniProtKB=T1G303 T1G303 20215451 PTHR45791:SF1 CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2 CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 1 HELRO|EnsemblGenome=HelroG113696|UniProtKB=T1EFV2 T1EFV2 20195454 PTHR45721:SF11 LAMIN DM0-RELATED LAMIN DM0-RELATED FAS signaling pathway#P00020>Nuclear Lamin#P00616 HELRO|EnsemblGenome=HelroG175172|UniProtKB=T1F8Y7 T1F8Y7 20205286 PTHR22738:SF10 RASSF RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 1 HOMOLOG regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG96397|UniProtKB=T1G9B8 T1G9B8 20217665 PTHR11905:SF159 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG62766|UniProtKB=T1FX49 T1FX49 20213397 PTHR31457:SF2 METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE C PROTEIN CYANOCOBALAMIN REDUCTASE _ ALKYLCOBALAMIN DEALKYLASE nucleotide binding#GO:0000166;demethylase activity#GO:0032451;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;oxidoreductase activity, acting on metal ions#GO:0016722;nucleoside phosphate binding#GO:1901265;flavin adenine dinucleotide binding#GO:0050660;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;oxidoreductase activity#GO:0016491 tetrapyrrole metabolic process#GO:0033013;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG192664|UniProtKB=T1FU62 T1FU62 20212358 PTHR10183:SF382 CALPAIN CALPAIN-15 cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG62728|UniProtKB=T1FX42 T1FX42 20213390 PTHR19290:SF164 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED BHLH DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;neurogenesis#GO:0022008;positive regulation of RNA biosynthetic process#GO:1902680;cell projection organization#GO:0030030;regulation of nitrogen compound metabolic process#GO:0051171;animal organ development#GO:0048513;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;regulation of biological process#GO:0050789;system development#GO:0048731;cell differentiation#GO:0030154;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;neuron differentiation#GO:0030182;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;multicellular organism development#GO:0007275;cellular component organization#GO:0016043;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;anatomical structure development#GO:0048856;biological regulation#GO:0065007;neuron development#GO:0048666;multicellular organismal process#GO:0032501;positive regulation of RNA metabolic process#GO:0051254;generation of neurons#GO:0048699;sensory organ development#GO:0007423;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG102896|UniProtKB=T1EDC8 T1EDC8 20194580 PTHR12606:SF141 SENTRIN/SUMO-SPECIFIC PROTEASE GH15225P-RELATED protease#PC00190 HELRO|EnsemblGenome=HelroG178453|UniProtKB=T1FD67 T1FD67 20206766 PTHR11819:SF150 SOLUTE CARRIER FAMILY 5 SODIUM_MYO-INOSITOL COTRANSPORTER inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;carbohydrate transmembrane transporter activity#GO:0015144;symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;sugar transmembrane transporter activity#GO:0051119;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;monoatomic ion transmembrane transporter activity#GO:0015075;inorganic cation transmembrane transporter activity#GO:0022890;solute:monoatomic cation symporter activity#GO:0015294 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG159849|UniProtKB=T1EPG9 T1EPG9 20198469 PTHR44942:SF4 METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172172|UniProtKB=T1F541 T1F541 20203940 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG96758|UniProtKB=T1G9D6 T1G9D6 20217683 PTHR19876:SF2 COATOMER COATOMER SUBUNIT BETA' endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;intra-Golgi vesicle-mediated transport#GO:0006891;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;vesicle coat#GO:0030120;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;Golgi-associated vesicle membrane#GO:0030660;protein-containing complex#GO:0032991;COPI vesicle coat#GO:0030126;endomembrane system#GO:0012505;membrane coat#GO:0030117;coated vesicle membrane#GO:0030662;COPI-coated vesicle#GO:0030137;Golgi-associated vesicle#GO:0005798;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;coated membrane#GO:0048475;cytoplasmic vesicle membrane#GO:0030659 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG159569|UniProtKB=T1EP64 T1EP64 20198364 PTHR12791:SF28 GOLGI SNARE BET1-RELATED BET1 HOMOLOG SNARE protein#PC00034 HELRO|EnsemblGenome=HelroG156425|UniProtKB=T1ELW3 T1ELW3 20197563 PTHR20917:SF0 PNAS-RELATED CALCIUM LOAD-ACTIVATED CALCIUM CHANNEL calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216 inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;chemical homeostasis#GO:0048878;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;monoatomic ion homeostasis#GO:0050801 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG156925|UniProtKB=T1EM33 T1EM33 20197633 PTHR12610:SF12 SINGLE STRANDED DNA BINDING PROTEIN SEQUENCE-SPECIFIC SINGLE-STRANDED DNA-BINDING PROTEIN, ISOFORM D positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG190021|UniProtKB=T1FRL6 T1FRL6 20211463 PTHR16291:SF0 NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3 NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;RNA cap binding#GO:0000339;binding#GO:0005488;organic cyclic compound binding#GO:0097159 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG70620|UniProtKB=T1G093 T1G093 20214491 PTHR23085:SF16 GH28348P GH28348P intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG103882|UniProtKB=T1EDI1 T1EDI1 20194633 PTHR24369:SF210 ANTIGEN BSP, PUTATIVE-RELATED CHAOPTIN-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG179260|UniProtKB=T1FEG2 T1FEG2 20207211 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG153989|UniProtKB=T1ELD5 T1ELD5 20197385 PTHR43226:SF1 XAA-PRO AMINOPEPTIDASE 3 XAA-PRO DIPEPTIDASE hydrolase activity#GO:0016787;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;metabolic process#GO:0008152;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG64733|UniProtKB=T1FXY3 T1FXY3 20213681 PTHR23349:SF97 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST BHLH DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG183998|UniProtKB=T1FKE5 T1FKE5 20209294 PTHR34009:SF2 PROTEIN STAR PROTEIN STAR localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;endosomal transport#GO:0016197;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987 bounding membrane of organelle#GO:0098588;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;late endosome membrane#GO:0031902;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;endosome membrane#GO:0010008;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle membrane#GO:0030659;endoplasmic reticulum#GO:0005783;late endosome#GO:0005770;plasma membrane#GO:0005886;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG173188|UniProtKB=T1F6I8 T1F6I8 20204437 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|Gene=LOX2|UniProtKB=Q01622 Q01622 LOX2 PTHR45659:SF4 HOMEOBOX PROTEIN HOX HOMEOBOX PROTEIN ABDOMINAL-A sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regionalization#GO:0003002;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;anterior/posterior pattern specification#GO:0009952;multicellular organismal process#GO:0032501;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;pattern specification process#GO:0007389;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG183244|UniProtKB=T1FJD0 T1FJD0 20208929 PTHR48192:SF1 ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG) HELRO|EnsemblGenome=HelroG112906|UniProtKB=T1EFN2 T1EFN2 20195384 PTHR11941:SF171 ENOYL-COA HYDRATASE-RELATED SD19268P oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;lipid oxidation#GO:0034440;cellular metabolic process#GO:0044237;lipid catabolic process#GO:0016042;lipid modification#GO:0030258;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;fatty acid catabolic process#GO:0009062;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;fatty acid metabolic process#GO:0006631;small molecule catabolic process#GO:0044282;fatty acid beta-oxidation#GO:0006635;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;carboxylic acid metabolic process#GO:0019752;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 hydratase#PC00120 HELRO|EnsemblGenome=HelroG173686|UniProtKB=T1F742 T1F742 20204641 PTHR45080:SF8 CONTACTIN 5 IG-LIKE DOMAIN-CONTAINING PROTEIN cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG183958|UniProtKB=T1FKC7 T1FKC7 20209276 PTHR10656:SF42 CELL FATE DETERMINING PROTEIN MAB21-RELATED CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED transferase#PC00220;nucleotidyltransferase#PC00174;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG186034|UniProtKB=T1FNK5 T1FNK5 20210402 PTHR43884:SF11 ACYL-COA DEHYDROGENASE VERY LONG-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;amide binding#GO:0033218;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;lipid binding#GO:0008289;anion binding#GO:0043168;ion binding#GO:0043167;oxidoreductase activity#GO:0016491 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG194346|UniProtKB=T1FVY6 T1FVY6 20212982 PTHR24412:SF172 KELCH PROTEIN KELCH-LIKE PROTEIN 10 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194066|UniProtKB=T1FVM9 T1FVM9 20212875 PTHR46825:SF15 D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG172908|UniProtKB=T1F642 T1F642 20204291 PTHR23349:SF108 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST BHLH DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG175489|UniProtKB=T1F9B5 T1F9B5 20205414 PTHR21461:SF69 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 glycosylation#GO:0070085;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG192583|UniProtKB=T1FU36 T1FU36 20212332 PTHR23184:SF9 TETRATRICOPEPTIDE REPEAT PROTEIN 14 TETRATRICOPEPTIDE REPEAT PROTEIN 14 HELRO|EnsemblGenome=HelroG91152|UniProtKB=T1G804 T1G804 20217201 PTHR23050:SF536 CALCIUM BINDING PROTEIN EF-HAND DOMAIN-CONTAINING PROTEIN cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 calmodulin-related#PC00061 B cell activation#P00010>Calmodulin#P00375;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Calmodulin#P00755;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716;T cell activation#P00053>Calmodulin#P01305 HELRO|EnsemblGenome=HelroG113572|UniProtKB=T1EFT9 T1EFT9 20195441 PTHR19384:SF17 NITRIC OXIDE SYNTHASE-RELATED NADPH--CYTOCHROME P450 REDUCTASE carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;flavin adenine dinucleotide binding#GO:0050660;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;oxidoreductase activity#GO:0016491 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176 Vitamin D metabolism and pathway#P04396>P450 reductase#P04605 HELRO|EnsemblGenome=HelroG188623|UniProtKB=T1FQ69 T1FQ69 20210966 PTHR10121:SF0 COATOMER SUBUNIT DELTA COATOMER SUBUNIT DELTA localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;organelle localization#GO:0051640;establishment of localization#GO:0051234;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;vesicle coat#GO:0030120;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;Golgi-associated vesicle membrane#GO:0030660;protein-containing complex#GO:0032991;COPI vesicle coat#GO:0030126;endomembrane system#GO:0012505;membrane coat#GO:0030117;coated vesicle membrane#GO:0030662;COPI-coated vesicle#GO:0030137;Golgi-associated vesicle#GO:0005798;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;coated membrane#GO:0048475;cytoplasmic vesicle membrane#GO:0030659 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG174285|UniProtKB=T1F7X9 T1F7X9 20204928 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG79233|UniProtKB=T1G3L7 T1G3L7 20215665 PTHR23033:SF14 BETA1,3-GALACTOSYLTRANSFERASE GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED galactosyltransferase activity#GO:0008378;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG191944|UniProtKB=T1FTF7 T1FTF7 20212104 PTHR13500:SF0 NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1 NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;biosynthetic process#GO:0009058;ribosomal large subunit biogenesis#GO:0042273;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;ribosome biogenesis#GO:0042254;maturation of 5.8S rRNA#GO:0000460;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;maturation of LSU-rRNA#GO:0000470 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG71489|UniProtKB=T1G0M2 T1G0M2 20214620 PTHR45723:SF1 SERINE/THREONINE-PROTEIN KINASE RIO1 SERINE_THREONINE-PROTEIN KINASE RIO3 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;preribosome, small subunit precursor#GO:0030688;preribosome#GO:0030684;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG112302|UniProtKB=T1EFI4 T1EFI4 20195336 PTHR13923:SF11 SEC31-RELATED PROTEIN SECRETORY 31, ISOFORM D endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;endoplasmic reticulum organization#GO:0007029;membrane organization#GO:0061024;transport#GO:0006810;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;vesicle budding from membrane#GO:0006900;organelle organization#GO:0006996;COPII-coated vesicle budding#GO:0090114;establishment of localization in cell#GO:0051649;vesicle organization#GO:0016050;intracellular transport#GO:0046907 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;ER to Golgi transport vesicle membrane#GO:0012507;endoplasmic reticulum exit site#GO:0070971;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;vesicle coat#GO:0030120;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;transport vesicle membrane#GO:0030658;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane coat#GO:0030117;coated vesicle membrane#GO:0030662;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;coated membrane#GO:0048475;cytoplasmic vesicle membrane#GO:0030659;endoplasmic reticulum#GO:0005783 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG168801|UniProtKB=T1F0Z7 T1F0Z7 20202497 PTHR31711:SF1 ARGININE AND GLUTAMATE-RICH PROTEIN 1 ARGININE AND GLUTAMATE-RICH PROTEIN 1 cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;binding#GO:0005488 membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG164334|UniProtKB=T1EV99 T1EV99 20200499 PTHR36191:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED VWFD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG156908|UniProtKB=T1EM28 T1EM28 20197628 PTHR10920:SF12 RIBOSOMAL RNA METHYLTRANSFERASE TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED tRNA methyltransferase activity#GO:0008175;catalytic activity, acting on RNA#GO:0140098;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;RNA methyltransferase activity#GO:0008173 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;peptide metabolic process#GO:0006518;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;translation#GO:0006412;ncRNA metabolic process#GO:0034660;tRNA methylation#GO:0030488;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cytoplasmic translation#GO:0002181;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nucleic acid metabolic process#GO:0090304;macromolecule methylation#GO:0043414;methylation#GO:0032259;RNA methylation#GO:0001510 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG167851|UniProtKB=T1EZV7 T1EZV7 20202107 PTHR13280:SF17 PHOSPHOFURIN ACIDIC CLUSTER SORTING PROTEIN KRUEPPEL TARGET AT 95D, ISOFORM A HELRO|EnsemblGenome=HelroG126217|UniProtKB=T1EH89 T1EH89 20195939 PTHR45771:SF6 HOMEOTIC PROTEIN DEFORMED HOMEOTIC PROTEIN SEX COMBS REDUCED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;pattern specification process#GO:0007389;positive regulation of biological process#GO:0048518;regulation of DNA-templated transcription#GO:0006355;multicellular organism development#GO:0007275;regionalization#GO:0003002;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;anatomical structure development#GO:0048856;biological regulation#GO:0065007;anterior/posterior pattern specification#GO:0009952;multicellular organismal process#GO:0032501;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG192336|UniProtKB=T1FTU2 T1FTU2 20212239 PTHR24044:SF417 NOTCH LIGAND FAMILY MEMBER WEARY, ISOFORM B protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG163910|UniProtKB=T1EUL9 T1EUL9 20200269 PTHR19303:SF74 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG68059|UniProtKB=T1FZ97 T1FZ97 20214145 PTHR12296:SF30 DENN DOMAIN-CONTAINING PROTEIN 4 DENN DOMAIN-CONTAINING PROTEIN CRAG regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;regulation of signaling#GO:0023051;biological regulation#GO:0065007;regulation of intracellular signal transduction#GO:1902531;regulation of small GTPase mediated signal transduction#GO:0051056 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG87641|UniProtKB=T1G6T5 T1G6T5 20216782 PTHR24241:SF76 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR NEUROPEPTIDE SIFAMIDE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;binding#GO:0005488;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888;amide binding#GO:0033218 response to organic substance#GO:0010033;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;response to hormone#GO:0009725;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG115114|UniProtKB=T1EG67 T1EG67 20195569 PTHR21394:SF0 MAU2 CHROMATID COHESION FACTOR HOMOLOG MAU2 CHROMATID COHESION FACTOR HOMOLOG nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 cellular component organization or biogenesis#GO:0071840;sister chromatid cohesion#GO:0007062;mitotic sister chromatid cohesion#GO:0007064;organelle organization#GO:0006996;chromosome organization#GO:0051276;cell cycle process#GO:0022402;cell cycle#GO:0007049;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;chromosome#GO:0005694;chromatin#GO:0000785;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG164182|UniProtKB=T1EV21 T1EV21 20200421 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG112400|UniProtKB=T1EFJ6 T1EFJ6 20195348 PTHR12860:SF0 SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68 ribonucleoprotein complex binding#GO:0043021;protein-containing complex binding#GO:0044877;binding#GO:0005488 localization within membrane#GO:0051668;cotranslational protein targeting to membrane#GO:0006613;cellular localization#GO:0051641;protein localization to endoplasmic reticulum#GO:0070972;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;protein targeting#GO:0006605;establishment of protein localization to organelle#GO:0072594;protein targeting to ER#GO:0045047;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;SRP-dependent cotranslational protein targeting to membrane#GO:0006614;localization#GO:0051179;establishment of protein localization to membrane#GO:0090150;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein localization to organelle#GO:0033365;establishment of protein localization to endoplasmic reticulum#GO:0072599 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG173940|UniProtKB=T1F7E4 T1F7E4 20204743 PTHR45721:SF12 LAMIN DM0-RELATED INTERMEDIATE FILAMENT PROTEIN IFA-1 structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;nuclear migration#GO:0007097;cellular localization#GO:0051641;negative regulation of biological process#GO:0048519;protein-DNA complex organization#GO:0071824;organelle localization#GO:0051640;macromolecule localization#GO:0033036;membrane organization#GO:0061024;transport#GO:0006810;protein localization to nucleus#GO:0034504;nucleus organization#GO:0006997;endomembrane system organization#GO:0010256;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;protein localization to organelle#GO:0033365;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;establishment of organelle localization#GO:0051656;negative regulation of cellular process#GO:0048523;localization within membrane#GO:0051668;negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;cellular process#GO:0009987;negative regulation of gene expression, epigenetic#GO:0045814;epigenetic regulation of gene expression#GO:0040029;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular macromolecule localization#GO:0070727;heterochromatin organization#GO:0070828;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;chromatin organization#GO:0006325;intracellular transport#GO:0046907;nuclear envelope organization#GO:0006998;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323;protein-containing complex localization#GO:0031503 membrane-enclosed lumen#GO:0031974;envelope#GO:0031975;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;nuclear periphery#GO:0034399;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981 HELRO|EnsemblGenome=HelroG155148|UniProtKB=T1ELH3 T1ELH3 20197423 PTHR46138:SF1 PROTEIN DR1 PROTEIN DR1 protein binding#GO:0005515;transcription factor binding#GO:0008134;binding#GO:0005488;TBP-class protein binding#GO:0017025 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;RNA metabolic process#GO:0016070;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein-DNA complex assembly#GO:0065004;RNA polymerase II preinitiation complex assembly#GO:0051123;nucleobase-containing compound metabolic process#GO:0006139;transcription initiation at RNA polymerase II promoter#GO:0006367;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG167821|UniProtKB=T1EZU2 T1EZU2 20202092 PTHR46880:SF5 RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170702|UniProtKB=T1F3C0 T1F3C0 20203319 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG180820|UniProtKB=T1FGB7 T1FGB7 20207866 PTHR31095:SF3 RIKEN CDNA 9930021J03 GENE RIKEN CDNA 9930021J03 GENE HELRO|EnsemblGenome=HelroG88758|UniProtKB=T1G760 T1G760 20216907 PTHR43157:SF31 PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG161682|UniProtKB=T1ERS4 T1ERS4 20199274 PTHR22950:SF646 AMINO ACID TRANSPORTER SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 10-RELATED L-amino acid transmembrane transporter activity#GO:0015179;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;amino acid transport#GO:0006865;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;nitrogen compound transport#GO:0071705;organic acid transmembrane transport#GO:1903825;carboxylic acid transport#GO:0046942;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039 cellular anatomical entity#GO:0110165;membrane#GO:0016020 amino acid transporter#PC00046;transporter#PC00227 HELRO|EnsemblGenome=HelroG164395|UniProtKB=T1EVD6 T1EVD6 20200536 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185317|UniProtKB=T1FMN5 T1FMN5 20210084 PTHR13056:SF0 VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;cellular process#GO:0009987;transport#GO:0006810 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG180223|UniProtKB=T1FFL2 T1FFL2 20207611 PTHR18895:SF74 HEMK METHYLTRANSFERASE MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG110232|UniProtKB=T1EF07 T1EF07 20195159 PTHR24104:SF57 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED BEE-MILK PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG105398|UniProtKB=T1EDU5 T1EDU5 20194747 PTHR10501:SF13 U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A nucleic acid binding#GO:0003676;RNA binding#GO:0003723;snRNA binding#GO:0017069;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;U1 snRNP#GO:0005685;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 mRNA splicing#P00058>U2#P01478;mRNA splicing#P00058>U1#P01479 HELRO|EnsemblGenome=HelroG106737|UniProtKB=T1EE44 T1EE44 20194846 PTHR11042:SF185 EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED WEE1-LIKE PROTEIN KINASE protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG94331|UniProtKB=T1G901 T1G901 20217548 PTHR23074:SF17 AAA DOMAIN-CONTAINING FIDGETIN-LIKE PROTEIN 1 pyrophosphatase activity#GO:0016462;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG185120|UniProtKB=T1FMF3 T1FMF3 20210002 PTHR10540:SF6 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F nucleic acid binding#GO:0003676;translation initiation factor binding#GO:0031369;translation regulator activity#GO:0045182;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation initiation factor activity#GO:0003743;protein binding#GO:0005515;translation regulator activity, nucleic acid binding#GO:0090079;translation factor activity, RNA binding#GO:0008135 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;translational initiation#GO:0006413;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;eukaryotic translation initiation factor 3 complex#GO:0005852;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489;Cell cycle#P00013>Proteasome#P00480 HELRO|EnsemblGenome=HelroG187930|UniProtKB=T1FPH3 T1FPH3 20210720 PTHR11607:SF3 ALPHA-MANNOSIDASE LYSOSOMAL ALPHA-MANNOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 glycosidase#PC00110;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG161527|UniProtKB=T1ERL2 T1ERL2 20199212 PTHR12231:SF253 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG67069|UniProtKB=T1FYV9 T1FYV9 20214007 PTHR11537:SF113 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;delayed rectifier potassium channel activity#GO:0005251;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG169949|UniProtKB=T1F2G9 T1F2G9 20203019 PTHR12352:SF3 SECRETED MODULAR CALCIUM-BINDING PROTEIN NIDOGEN-2 extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG165453|UniProtKB=T1EWT9 T1EWT9 20201039 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG185831|UniProtKB=T1FNC5 T1FNC5 20210322 PTHR15350:SF2 COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cytoplasmic translation#GO:0002181;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cytoplasmic translational initiation#GO:0002183;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;translation#GO:0006412;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;translational initiation#GO:0006413;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;eukaryotic translation initiation factor 3 complex#GO:0005852;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG166721|UniProtKB=T1EYF5 T1EYF5 20201605 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194118|UniProtKB=T1FVQ0 T1FVQ0 20212896 PTHR23172:SF19 AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED J DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;clathrin binding#GO:0030276;binding#GO:0005488 localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;cellular component disassembly#GO:0022411;protein-containing complex disassembly#GO:0032984;establishment of localization#GO:0051234;clathrin-dependent endocytosis#GO:0072583;protein-containing complex organization#GO:0043933;transport#GO:0006810;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;receptor-mediated endocytosis#GO:0006898;protein depolymerization#GO:0051261;cellular component organization#GO:0016043;cellular process#GO:0009987;import into cell#GO:0098657 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG158241|UniProtKB=T1EML0 T1EML0 20197810 PTHR30615:SF8 UNCHARACTERIZED PROTEIN YJBQ-RELATED UPF0047 PROTEIN C4A8.02C HELRO|EnsemblGenome=HelroG175057|UniProtKB=T1F8S7 T1F8S7 20205226 PTHR10131:SF94 TNF RECEPTOR ASSOCIATED FACTOR TNF RECEPTOR-ASSOCIATED FACTOR 4 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG161235|UniProtKB=T1ER87 T1ER87 20199087 PTHR12485:SF1 NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 7 mitochondrial ATP synthesis coupled electron transport#GO:0042775;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;mitochondrial electron transport, NADH to ubiquinone#GO:0006120;respiratory electron transport chain#GO:0022904;aerobic electron transport chain#GO:0019646;oxidative phosphorylation#GO:0006119;generation of precursor metabolites and energy#GO:0006091;electron transport chain#GO:0022900;ATP synthesis coupled electron transport#GO:0042773;cellular metabolic process#GO:0044237;cellular process#GO:0009987;energy derivation by oxidation of organic compounds#GO:0015980;metabolic process#GO:0008152 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transporter complex#GO:1990351;oxidoreductase complex#GO:1990204;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;respirasome#GO:0070469;mitochondrial respiratory chain complex I#GO:0005747;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;mitochondrial respirasome#GO:0005746;transmembrane transporter complex#GO:1902495;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;respiratory chain complex I#GO:0045271;NADH dehydrogenase complex#GO:0030964;mitochondrial protein-containing complex#GO:0098798 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG159291|UniProtKB=T1ENU5 T1ENU5 20198245 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG180810|UniProtKB=T1FGB1 T1FGB1 20207860 PTHR16019:SF6 SYNAPSE-ASSOCIATED PROTEIN SYNAPSE-ASSOCIATED PROTEIN 1 regulation of cell communication#GO:0010646;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of signaling#GO:0023051;cell communication#GO:0007154;TORC2 signaling#GO:0038203;cellular process#GO:0009987;regulation of synaptic plasticity#GO:0048167;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of biological quality#GO:0065008;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177;regulation of neuronal synaptic plasticity#GO:0048168;intracellular signal transduction#GO:0035556;signaling#GO:0023052;TOR signaling#GO:0031929 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG64160|UniProtKB=T1FXQ5 T1FXQ5 20213603 PTHR15241:SF391 TRANSFORMER-2-RELATED RRM DOMAIN-CONTAINING PROTEIN RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG169904|UniProtKB=T1F2F4 T1F2F4 20203004 PTHR35270:SF2 FUSELESS, ISOFORM A FUSELESS, ISOFORM A HELRO|EnsemblGenome=HelroG176316|UniProtKB=T1FAD9 T1FAD9 20205788 PTHR14918:SF3 KICSTOR COMPLEX PROTEIN SZT2 KICSTOR COMPLEX PROTEIN SZT2 HELRO|EnsemblGenome=HelroG174252|UniProtKB=T1F7W1 T1F7W1 20204910 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183610|UniProtKB=T1FJX5 T1FJX5 20209124 PTHR42757:SF32 IGLON FAMILY OF IMMUNOGLOBULIN SUPERFAMILY-RELATED PROTEIN AMALGAM defense/immunity protein#PC00090;immunoglobulin#PC00123 HELRO|EnsemblGenome=HelroG80653|UniProtKB=T1G435 T1G435 20215833 PTHR23055:SF69 CALCIUM BINDING PROTEINS NEURONAL CALCIUM SENSOR 2 cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG183456|UniProtKB=T1FJP5 T1FJP5 20209044 PTHR13633:SF3 MITOCHONDRIAL TRANSCRIPTION RESCUE FACTOR 1 MITOCHONDRIAL TRANSCRIPTION RESCUE FACTOR 1 HELRO|EnsemblGenome=HelroG174564|UniProtKB=T1F894 T1F894 20205043 PTHR24366:SF96 IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS LEUCINE RICH REPEAT CONTAINING 53 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG193697|UniProtKB=T1FV98 T1FV98 20212744 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG172351|UniProtKB=T1F578 T1F578 20203977 PTHR10589:SF16 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5 cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protease#PC00190 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG163156|UniProtKB=T1ETQ8 T1ETQ8 20199958 PTHR10388:SF4 EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1 EUKARYOTIC TRANSLATION INITIATION FACTOR EIF1 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG186190|UniProtKB=T1FNS6 T1FNS6 20210473 PTHR46340:SF1 UBX DOMAIN-CONTAINING PROTEIN 1 UBX DOMAIN-CONTAINING PROTEIN 1 protein binding#GO:0005515;binding#GO:0005488;polyubiquitin modification-dependent protein binding#GO:0031593;modification-dependent protein binding#GO:0140030 negative regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032435;regulation of proteolysis#GO:0030162;negative regulation of biological process#GO:0048519;regulation of protein modification process#GO:0031399;regulation of protein metabolic process#GO:0051246;regulation of catabolic process#GO:0009894;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of protein catabolic process#GO:0042177;negative regulation of metabolic process#GO:0009892;regulation of protein catabolic process#GO:0042176;negative regulation of protein metabolic process#GO:0051248;negative regulation of proteolysis#GO:0045861;regulation of proteolysis involved in protein catabolic process#GO:1903050;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of proteasomal protein catabolic process#GO:0061136;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of proteasomal protein catabolic process#GO:1901799;negative regulation of protein modification process#GO:0031400;negative regulation of catabolic process#GO:0009895;regulation of macromolecule metabolic process#GO:0060255;negative regulation of protein ubiquitination#GO:0031397;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of proteolysis involved in protein catabolic process#GO:1903051;regulation of metabolic process#GO:0019222;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG168571|UniProtKB=T1F0R0 T1F0R0 20202410 PTHR22968:SF24 PROTEIN KINASE C, MU SERINE_THREONINE-PROTEIN KINASE transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;signaling#GO:0023052 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 VEGF signaling pathway#P00056>PKC#P01425;Angiogenesis#P00005>PKC#P00219;EGF receptor signaling pathway#P00018>PKC#P00565 HELRO|EnsemblGenome=HelroG108105|UniProtKB=T1EEF5 T1EEF5 20194957 PTHR24023:SF1097 COLLAGEN ALPHA COLLAGEN ALPHA-1(VII) CHAIN ISOFORM X1 structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG105102|UniProtKB=T1EDQ8 T1EDQ8 20194710 PTHR10953:SF3 UBIQUITIN-ACTIVATING ENZYME E1 UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7 ligase activity#GO:0016874;transferase activity#GO:0016740;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877;nucleotidyltransferase activity#GO:0016779;thiosulfate sulfurtransferase activity#GO:0004792;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity, acting on a protein#GO:0140096;sulfurtransferase activity#GO:0016783 microautophagy#GO:0016237;cellular component biogenesis#GO:0044085;macroautophagy#GO:0016236;macromolecule modification#GO:0043412;protein modification process#GO:0036211;autophagy of mitochondrion#GO:0000422;response to extracellular stimulus#GO:0009991;biosynthetic process#GO:0009058;post-translational protein modification#GO:0043687;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;cellular component disassembly#GO:0022411;cellular response to starvation#GO:0009267;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;mitochondrion organization#GO:0007005;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;protein lipidation#GO:0006497;cellular response to extracellular stimulus#GO:0031668;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;cellular response to stimulus#GO:0051716;macromolecule biosynthetic process#GO:0009059;protein modification by small protein conjugation or removal#GO:0070647;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;cellular component organization#GO:0016043;response to nutrient levels#GO:0031667;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organelle disassembly#GO:1903008;lipoprotein biosynthetic process#GO:0042158;primary metabolic process#GO:0044238;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to stress#GO:0006950;organelle organization#GO:0006996;cellular response to nutrient levels#GO:0031669;response to starvation#GO:0042594;cellular response to external stimulus#GO:0071496;autophagosome assembly#GO:0000045;lipoprotein metabolic process#GO:0042157;cellular response to stress#GO:0033554;piecemeal microautophagy of the nucleus#GO:0034727;autophagy#GO:0006914 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;phagophore assembly site#GO:0000407;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E1#P01492 HELRO|EnsemblGenome=HelroG167838|UniProtKB=T1EZV1 T1EZV1 20202101 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165595|UniProtKB=T1EX20 T1EX20 20201120 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180349|UniProtKB=T1FFS8 T1FFS8 20207677 PTHR46670:SF2 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191869|UniProtKB=T1FTD4 T1FTD4 20212081 PTHR13817:SF151 TITIN TITIN sarcomere organization#GO:0045214;cellular component assembly#GO:0022607;cellular developmental process#GO:0048869;cellular component biogenesis#GO:0044085;cellular component assembly involved in morphogenesis#GO:0010927;muscle cell differentiation#GO:0042692;developmental process#GO:0032502;actomyosin structure organization#GO:0031032;cellular component organization#GO:0016043;myofibril assembly#GO:0030239;cellular process#GO:0009987;anatomical structure formation involved in morphogenesis#GO:0048646;cellular anatomical entity morphogenesis#GO:0032989;muscle cell development#GO:0055001;cell development#GO:0048468;organelle assembly#GO:0070925;muscle structure development#GO:0061061;cellular component organization or biogenesis#GO:0071840;striated muscle cell differentiation#GO:0051146;cell differentiation#GO:0030154;actin filament-based process#GO:0030029;anatomical structure morphogenesis#GO:0009653;organelle organization#GO:0006996;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;striated muscle cell development#GO:0055002;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;non-membrane-bounded organelle assembly#GO:0140694 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;sarcomere#GO:0030017;A band#GO:0031672;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;organelle#GO:0043226;M band#GO:0031430;myofibril#GO:0030016;contractile fiber#GO:0043292;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 structural protein#PC00211 HELRO|EnsemblGenome=HelroG94766|UniProtKB=T1G930 T1G930 20217577 PTHR11140:SF0 PRE-MRNA SPLICING FACTOR PRP8 PRE-MRNA-PROCESSING-SPLICING FACTOR 8 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;snRNA binding#GO:0017069;pre-mRNA binding#GO:0036002;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;spliceosomal snRNP assembly#GO:0000387;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375 catalytic step 2 spliceosome#GO:0071013;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;U5 snRNP#GO:0005682;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;protein-containing complex#GO:0032991;small nuclear ribonucleoprotein complex#GO:0030532;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG176341|UniProtKB=T1FAE7 T1FAE7 20205796 PTHR46186:SF2 CYSTATIN CYSTATIN peptidase inhibitor activity#GO:0030414;molecular function regulator activity#GO:0098772;cysteine-type endopeptidase inhibitor activity#GO:0004869;peptidase regulator activity#GO:0061134;enzyme inhibitor activity#GO:0004857;endopeptidase regulator activity#GO:0061135;endopeptidase inhibitor activity#GO:0004866;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 regulation of proteolysis#GO:0030162;negative regulation of hydrolase activity#GO:0051346;negative regulation of biological process#GO:0048519;regulation of protein metabolic process#GO:0051246;regulation of cysteine-type endopeptidase activity#GO:2000116;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of cysteine-type endopeptidase activity#GO:2000117;negative regulation of peptidase activity#GO:0010466;negative regulation of endopeptidase activity#GO:0010951;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of proteolysis#GO:0045861;regulation of catalytic activity#GO:0050790;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of molecular function#GO:0065009;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336;regulation of endopeptidase activity#GO:0052548;regulation of peptidase activity#GO:0052547;negative regulation of catalytic activity#GO:0043086;regulation of metabolic process#GO:0019222;negative regulation of molecular function#GO:0044092 cytoplasm#GO:0005737;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG78915|UniProtKB=T1G3H3 T1G3H3 20215621 PTHR12086:SF11 EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN EF-HAND DOMAIN-CONTAINING FAMILY MEMBER C2 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG179324|UniProtKB=T1FEJ7 T1FEJ7 20207246 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG160543|UniProtKB=T1EQE4 T1EQE4 20198794 PTHR23107:SF34 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN HTH LA-TYPE RNA-BINDING DOMAIN-CONTAINING PROTEIN transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG166371|UniProtKB=T1EY24 T1EY24 20201474 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG67647|UniProtKB=T1FZ32 T1FZ32 20214080 PTHR14340:SF9 MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3 FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG86882|UniProtKB=T1G6I7 T1G6I7 20216684 PTHR14499:SF136 POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING GH08630P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194695|UniProtKB=T1FWB9 T1FWB9 20213115 PTHR21681:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical entity#GO:0110165;eukaryotic translation initiation factor 3 complex#GO:0005852;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG161564|UniProtKB=T1ERM2 T1ERM2 20199222 PTHR19307:SF14 TUMOR PROTEIN D52 TUMOR PROTEIN D52 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG194208|UniProtKB=T1FVT2 T1FVT2 20212928 PTHR46641:SF25 FMRFAMIDE RECEPTOR-RELATED CNMAMIDE RECEPTOR-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG107285|UniProtKB=T1EE93 T1EE93 20194895 PTHR47238:SF4 MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5 MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG62259|UniProtKB=T1FWX9 T1FWX9 20213327 PTHR18945:SF865 NEUROTRANSMITTER GATED ION CHANNEL NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA7, ISOFORM E ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG194249|UniProtKB=T1FVU9 T1FVU9 20212945 PTHR14596:SF76 ZINC FINGER PROTEIN DEFECTIVE CHORION PROTEIN, FC177 ISOFORM cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to nutrient levels#GO:0031667;response to extracellular stimulus#GO:0009991;response to stress#GO:0006950;response to starvation#GO:0042594 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG159819|UniProtKB=T1EPF9 T1EPF9 20198459 PTHR13621:SF2 PROLINE-RICH PROTEIN PRCC PROLINE-RICH PROTEIN PRCC membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG189692|UniProtKB=T1FR94 T1FR94 20211341 PTHR14186:SF19 INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 7 regulation of response to stimulus#GO:0048583;biological regulation#GO:0065007;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;regulation of signaling#GO:0023051 HELRO|EnsemblGenome=HelroG140484|UniProtKB=T1EJ12 T1EJ12 20196562 PTHR21208:SF1 ADP-DEPENDENT GLUCOKINASE ADP-DEPENDENT GLUCOKINASE carbohydrate metabolic process#GO:0005975;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238;metabolic process#GO:0008152 transferase#PC00220;kinase#PC00137;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG70554|UniProtKB=T1G083 T1G083 20214481 PTHR45695:SF15 LEUCOKININ RECEPTOR-RELATED OPSIN RH2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Rhodopsin#P00747 HELRO|EnsemblGenome=HelroG83625|UniProtKB=T1G583 T1G583 20216230 PTHR24346:SF45 MAP/MICROTUBULE AFFINITY-REGULATING KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG108045|UniProtKB=T1EEE8 T1EEE8 20194950 PTHR42919:SF8 N-ALPHA-ACETYLTRANSFERASE N-ALPHA-ACETYLTRANSFERASE 50 acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG167067|UniProtKB=T1EYY9 T1EYY9 20201789 PTHR48125:SF16 LP07818P1 UBZ4-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162142|UniProtKB=T1ESA2 T1ESA2 20199452 PTHR10642:SF26 RIBONUCLEASE H1 RIBONUCLEASE H1 catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular nitrogen compound catabolic process#GO:0044270;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic cyclic compound catabolic process#GO:1901361;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;organic substance catabolic process#GO:1901575;nucleobase-containing compound catabolic process#GO:0034655;DNA replication#GO:0006260;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;cellular catabolic process#GO:0044248 endoribonuclease#PC00094;RNA metabolism protein#PC00031 DNA replication#P00017>RNase H#P00538 HELRO|EnsemblGenome=HelroG157204|UniProtKB=T1EM81 T1EM81 20197681 PTHR23249:SF15 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4 localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987 protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;vesicle tethering complex#GO:0099023;TRAPP complex#GO:0030008 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG172681|UniProtKB=T1F5S1 T1F5S1 20204170 PTHR47510:SF9 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG153641|UniProtKB=T1ELA5 T1ELA5 20197355 PTHR10083:SF381 KUNITZ-TYPE PROTEASE INHIBITOR-RELATED BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN peptidase inhibitor activity#GO:0030414;molecular function regulator activity#GO:0098772;serine-type endopeptidase inhibitor activity#GO:0004867;peptidase regulator activity#GO:0061134;enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;endopeptidase regulator activity#GO:0061135;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG145942|UniProtKB=T1EJP0 T1EJP0 20196790 PTHR33332:SF40 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG156024|UniProtKB=T1ELQ8 T1ELQ8 20197508 PTHR12442:SF7 DYNEIN INTERMEDIATE CHAIN DYNEIN AXONEMAL INTERMEDIATE CHAIN 2 protein binding#GO:0005515;binding#GO:0005488 cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;outer dynein arm assembly#GO:0036158;cell projection organization#GO:0030030;microtubule cytoskeleton organization#GO:0000226;microtubule-based movement#GO:0007018;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;axoneme assembly#GO:0035082;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;cilium movement#GO:0003341;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection assembly#GO:0120031 axoneme#GO:0005930;outer dynein arm#GO:0036157;catalytic complex#GO:1902494;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;microtubule associated complex#GO:0005875;axonemal dynein complex#GO:0005858;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;ciliary plasm#GO:0097014;plasma membrane bounded cell projection cytoplasm#GO:0032838;membrane-bounded organelle#GO:0043227;dynein complex#GO:0030286;cell projection#GO:0042995;cytoskeleton#GO:0005856;cilium#GO:0005929 microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Dynein complex#P00774 HELRO|EnsemblGenome=HelroG68810|UniProtKB=T1FZJ7 T1FZJ7 20214245 PTHR45628:SF7 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated calcium channel activity#GO:0005245;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;calcium ion transport#GO:0006816;localization#GO:0051179;calcium ion import#GO:0070509;import across plasma membrane#GO:0098739;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;calcium ion transmembrane import into cytosol#GO:0097553;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657 voltage-gated calcium channel complex#GO:0005891;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;calcium channel complex#GO:0034704;membrane#GO:0016020;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 Ionotropic glutamate receptor pathway#P00037>Ca2+ channel#P01022;Thyrotropin-releasing hormone receptor signaling pathway#P04394>Ca2+ channel#P04587;Metabotropic glutamate receptor group II pathway#P00040>Ca2+#P01051;Metabotropic glutamate receptor group III pathway#P00039>Ca2+#P01041 HELRO|EnsemblGenome=HelroG75258|UniProtKB=T1G231 T1G231 20215129 PTHR11575:SF24 5'-NUCLEOTIDASE-RELATED 5'-NUCLEOTIDASE phosphodiesterase#PC00185;metabolite interconversion enzyme#PC00262 Pyrimidine Metabolism#P02771>5'-Nucleotidase#P03131;Purine metabolism#P02769>5'-Nucleotidase#P03119 HELRO|EnsemblGenome=HelroG113006|UniProtKB=T1EFP5 T1EFP5 20195397 PTHR10048:SF7 PHOSPHATIDYLINOSITOL KINASE PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;catalytic activity#GO:0003824;lipid kinase activity#GO:0001727 lipid metabolic process#GO:0006629;cellular component biogenesis#GO:0044085;signal transduction#GO:0007165;phospholipid biosynthetic process#GO:0008654;macroautophagy#GO:0016236;phosphatidylinositol biosynthetic process#GO:0006661;organophosphate biosynthetic process#GO:0090407;transport#GO:0006810;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;glycerolipid metabolic process#GO:0046486;establishment of localization#GO:0051234;catabolic process#GO:0009056;intracellular signal transduction#GO:0035556;signaling#GO:0023052;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;cellular response to stimulus#GO:0051716;glycerolipid biosynthetic process#GO:0045017;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;localization#GO:0051179;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;glycerophospholipid biosynthetic process#GO:0046474;biological regulation#GO:0065007;autophagosome assembly#GO:0000045;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;autophagy#GO:0006914;import into cell#GO:0098657 membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;phosphatidylinositol 3-kinase complex#GO:0005942;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;phosphatidylinositol 3-kinase complex, class III#GO:0035032;vesicle#GO:0031982;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;extrinsic component of membrane#GO:0019898;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;phagophore assembly site#GO:0000407;endomembrane system#GO:0012505;peroxisome#GO:0005777;microbody#GO:0042579;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410 kinase#PC00137 PDGF signaling pathway#P00047>PI3K#P01168;T cell activation#P00053>PI3K#P01322;Hypoxia response via HIF activation#P00030>PI3K#P00823;Angiogenesis#P00005>PI3K#P00236;EGF receptor signaling pathway#P00018>PI3K#P00557;VEGF signaling pathway#P00056>PI3K#P01413;FGF signaling pathway#P00021>PI3K#P00640;Ras Pathway#P04393>PI3K#P04567;p53 pathway feedback loops 2#P04398>PI3K#P04661;p53 pathway#P00059>PI3K#P04609;Endothelin signaling pathway#P00019>PI3K#P00577;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PI3K#P00900;Integrin signalling pathway#P00034>PI3K#P00936 HELRO|EnsemblGenome=HelroG178192|UniProtKB=T1FCX1 T1FCX1 20206670 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178948|UniProtKB=T1FDY0 T1FDY0 20207029 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG175840|UniProtKB=T1F9R2 T1F9R2 20205561 PTHR22748:SF6 AP ENDONUCLEASE DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE hydrolase activity, acting on ester bonds#GO:0016788;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;3'-5'-DNA exonuclease activity#GO:0008296;nuclease activity#GO:0004518;DNA exonuclease activity#GO:0004529;catalytic activity#GO:0003824;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097;phosphoric diester hydrolase activity#GO:0008081;exonuclease activity#GO:0004527;3'-5' exonuclease activity#GO:0008408;phosphoric ester hydrolase activity#GO:0042578 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;base-excision repair#GO:0006284;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 HELRO|EnsemblGenome=HelroG186311|UniProtKB=T1FNY3 T1FNY3 20210530 PTHR10545:SF29 DIAMINE N-ACETYLTRANSFERASE GH14572P-RELATED acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;catalytic activity#GO:0003824;N-acyltransferase activity#GO:0016410 acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG98923|UniProtKB=T1G9Q4 T1G9Q4 20217800 PTHR12889:SF0 GAMMA-SECRETASE SUBUNIT APH-1 GAMMA-SECRETASE SUBUNIT APH-1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;plasma membrane#GO:0005886 protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Aph-1#P00170;Notch signaling pathway#P00045>Aph-1#P01109;Alzheimer disease-amyloid secretase pathway#P00003>Aph-1#P00091 HELRO|EnsemblGenome=HelroG186384|UniProtKB=T1FNZ0 T1FNZ0 20210537 PTHR45632:SF17 LD33804P KELCH-LIKE PROTEIN 31 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG189946|UniProtKB=T1FRI7 T1FRI7 20211434 PTHR32026:SF10 METHYLTRANSFERASE-LIKE PROTEIN 24 METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG64381|UniProtKB=T1FXU0 T1FXU0 20213638 PTHR11849:SF190 ETS ETS-DOMAIN PROTEIN transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG186994|UniProtKB=T1FP51 T1FP51 20210598 PTHR23238:SF31 RNA BINDING PROTEIN GH13594P-RELATED molecular adaptor activity#GO:0060090;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;transcription coregulator activity#GO:0003712;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159;protein-macromolecule adaptor activity#GO:0030674 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG185045|UniProtKB=T1FMB8 T1FMB8 20209967 PTHR16461:SF5 TOLL-INTERACTING PROTEIN TOLL-INTERACTING PROTEIN enzyme binding#GO:0019899;ubiquitin-like protein conjugating enzyme binding#GO:0044390;protein binding#GO:0005515;ubiquitin-like protein binding#GO:0032182;binding#GO:0005488;ubiquitin binding#GO:0043130 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 Toll receptor signaling pathway#P00054>Tollip#P01379 HELRO|EnsemblGenome=HelroG163568|UniProtKB=T1EU79 T1EU79 20200129 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG76537|UniProtKB=T1G2L2 T1G2L2 20215310 PTHR45771:SF6 HOMEOTIC PROTEIN DEFORMED HOMEOTIC PROTEIN SEX COMBS REDUCED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;pattern specification process#GO:0007389;positive regulation of biological process#GO:0048518;regulation of DNA-templated transcription#GO:0006355;multicellular organism development#GO:0007275;regionalization#GO:0003002;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;anatomical structure development#GO:0048856;biological regulation#GO:0065007;anterior/posterior pattern specification#GO:0009952;multicellular organismal process#GO:0032501;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG164477|UniProtKB=T1EVH2 T1EVH2 20200572 PTHR36162:SF20 FAMILY NOT NAMED GLUTAMINE-RICH PROTEIN 2 HELRO|EnsemblGenome=HelroG173103|UniProtKB=T1F6C7 T1F6C7 20204376 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184949|UniProtKB=T1FM73 T1FM73 20209922 PTHR31581:SF1 KICSTOR COMPLEX PROTEIN C12ORF66 KICSTOR SUBUNIT 2 cellular localization#GO:0051641;negative regulation of biological process#GO:0048519;macromolecule localization#GO:0033036;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;response to extracellular stimulus#GO:0009991;regulation of intracellular signal transduction#GO:1902531;negative regulation of TOR signaling#GO:0032007;regulation of biological process#GO:0050789;cellular response to starvation#GO:0009267;regulation of signal transduction#GO:0009966;protein localization to organelle#GO:0033365;negative regulation of cell communication#GO:0010648;negative regulation of cellular process#GO:0048523;cellular response to extracellular stimulus#GO:0031668;regulation of cell communication#GO:0010646;cellular response to stimulus#GO:0051716;regulation of TORC1 signaling#GO:1903432;negative regulation of response to stimulus#GO:0048585;protein localization to vacuole#GO:0072665;negative regulation of signaling#GO:0023057;cell communication#GO:0007154;response to nutrient levels#GO:0031667;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;protein localization#GO:0008104;localization#GO:0051179;regulation of response to stimulus#GO:0048583;response to external stimulus#GO:0009605;response to stimulus#GO:0050896;protein localization to lysosome#GO:0061462;cellular macromolecule localization#GO:0070727;response to stress#GO:0006950;cellular response to nutrient levels#GO:0031669;regulation of cellular process#GO:0050794;response to starvation#GO:0042594;biological regulation#GO:0065007;cellular response to external stimulus#GO:0071496;negative regulation of signal transduction#GO:0009968;cellular response to amino acid starvation#GO:0034198;cellular response to stress#GO:0033554;negative regulation of TORC1 signaling#GO:1904262 protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG122508|UniProtKB=T1EGU8 T1EGU8 20195798 PTHR11537:SF113 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;delayed rectifier potassium channel activity#GO:0005251;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG73015|UniProtKB=T1G186 T1G186 20214834 PTHR23280:SF25 4.1 G PROTEIN MOESIN_EZRIN_RADIXIN HOMOLOG 1 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;actomyosin structure organization#GO:0031032;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG100373|UniProtKB=T1ECZ4 T1ECZ4 20194446 PTHR23115:SF170 TRANSLATION FACTOR ELONGATION FACTOR 1-ALPHA 2 translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG174216|UniProtKB=T1F7T5 T1F7T5 20204884 PTHR19303:SF71 TRANSPOSON ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG66923|UniProtKB=T1FYT2 T1FYT2 20213980 PTHR24418:SF458 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE CSK protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 non-receptor tyrosine protein kinase#PC00168 Integrin signalling pathway#P00034>Csk#P00913;Parkinson disease#P00049>Src kinase#P01230;CCKR signaling map#P06959>CSK#P07072;T cell activation#P00053>Csk#P01304 HELRO|EnsemblGenome=HelroG74506|UniProtKB=T1G1S0 T1G1S0 20215018 PTHR24637:SF388 COLLAGEN NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG68926|UniProtKB=T1FZL9 T1FZL9 20214267 PTHR12595:SF0 POS9-ACTIVATING FACTOR FAP7-RELATED ADENYLATE KINASE ISOENZYME 6 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG131366|UniProtKB=T1EHV7 T1EHV7 20196157 PTHR12537:SF12 RNA BINDING PROTEIN PUMILIO-RELATED MATERNAL PROTEIN PUMILIO nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG184852|UniProtKB=T1FM31 T1FM31 20209880 PTHR10252:SF8 HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 Gonadotropin-releasing hormone receptor pathway#P06664>NF-Y#P06742 HELRO|EnsemblGenome=HelroG85345|UniProtKB=T1G5V6 T1G5V6 20216453 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185224|UniProtKB=T1FMJ1 T1FMJ1 20210040 PTHR44279:SF2 HYDROXYSTEROID (11-BETA) DEHYDROGENASE 1-LIKE B-RELATED HYDROXYSTEROID (11-BETA) DEHYDROGENASE 1-LIKE B-RELATED oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG176457|UniProtKB=T1FAJ0 T1FAJ0 20205839 PTHR15741:SF25 BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR MAX-LIKE PROTEIN X sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG185539|UniProtKB=T1FMY2 T1FMY2 20210181 PTHR12370:SF3 PHOSPHOLIPASE B-RELATED PHOSPHOLIPASE B-LIKE 2-RELATED hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;phospholipase activity#GO:0004620;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;cellular metabolic process#GO:0044237;lipid catabolic process#GO:0016042;cellular process#GO:0009987;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;organophosphate catabolic process#GO:0046434;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;phospholipid catabolic process#GO:0009395;catabolic process#GO:0009056;organophosphate metabolic process#GO:0019637;organic substance catabolic process#GO:1901575;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248 cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 phospholipase#PC00186;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG99230|UniProtKB=T1G9R6 T1G9R6 20217812 PTHR18919:SF153 ACETYL-COA C-ACYLTRANSFERASE TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;lipid oxidation#GO:0034440;cellular metabolic process#GO:0044237;lipid catabolic process#GO:0016042;lipid modification#GO:0030258;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;fatty acid catabolic process#GO:0009062;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;fatty acid metabolic process#GO:0006631;small molecule catabolic process#GO:0044282;fatty acid beta-oxidation#GO:0006635;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;carboxylic acid metabolic process#GO:0019752;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG73612|UniProtKB=T1G1G4 T1G1G4 20214912 PTHR12442:SF7 DYNEIN INTERMEDIATE CHAIN DYNEIN AXONEMAL INTERMEDIATE CHAIN 2 protein binding#GO:0005515;binding#GO:0005488 cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;outer dynein arm assembly#GO:0036158;cell projection organization#GO:0030030;microtubule cytoskeleton organization#GO:0000226;microtubule-based movement#GO:0007018;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;axoneme assembly#GO:0035082;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;cilium movement#GO:0003341;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection assembly#GO:0120031 axoneme#GO:0005930;outer dynein arm#GO:0036157;catalytic complex#GO:1902494;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;microtubule associated complex#GO:0005875;axonemal dynein complex#GO:0005858;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;ciliary plasm#GO:0097014;plasma membrane bounded cell projection cytoplasm#GO:0032838;membrane-bounded organelle#GO:0043227;dynein complex#GO:0030286;cell projection#GO:0042995;cytoskeleton#GO:0005856;cilium#GO:0005929 microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Dynein complex#P00774 HELRO|EnsemblGenome=HelroG184444|UniProtKB=T1FL78 T1FL78 20209577 PTHR33865:SF3 PROTEIN FAM183B PROTEIN FAM183B membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cilium#GO:0005929;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;ciliary base#GO:0097546 HELRO|EnsemblGenome=HelroG192317|UniProtKB=T1FTT8 T1FTT8 20212235 PTHR21345:SF3 SPIRE PROTEIN SPIRE cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;cell division#GO:0051301;organelle localization#GO:0051640;membrane organization#GO:0061024;cellular process involved in reproduction in multicellular organism#GO:0022412;nuclear division#GO:0000280;transport#GO:0006810;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;protein-containing complex assembly#GO:0065003;actin filament polymerization#GO:0030041;cytokinetic process#GO:0032506;actin filament-based process#GO:0030029;membrane invagination#GO:0010324;establishment of localization#GO:0051234;meiotic cell cycle process#GO:1903046;supramolecular fiber organization#GO:0097435;cytoskeleton-dependent cytokinesis#GO:0061640;actin filament organization#GO:0007015;reproductive process#GO:0022414;cytoskeleton organization#GO:0007010;establishment of organelle localization#GO:0051656;cytokinesis#GO:0000910;spindle localization#GO:0051653;multicellular organismal reproductive process#GO:0048609;cellular component assembly#GO:0022607;gamete generation#GO:0007276;multicellular organism reproduction#GO:0032504;meiotic cell cycle#GO:0051321;vesicle-mediated transport#GO:0016192;actin polymerization or depolymerization#GO:0008154;cellular component organization#GO:0016043;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;establishment of spindle localization#GO:0051293;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;reproduction#GO:0000003;microtubule-based process#GO:0007017;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;meiotic nuclear division#GO:0140013;sexual reproduction#GO:0019953;protein polymerization#GO:0051258;cell cycle#GO:0007049;multicellular organismal process#GO:0032501;establishment of localization in cell#GO:0051649;organelle fission#GO:0048285;intracellular transport#GO:0046907;actin cytoskeleton organization#GO:0030036 intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;cell periphery#GO:0071944;cell cortex#GO:0005938;cellular anatomical entity#GO:0110165;vesicle membrane#GO:0012506;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cytoplasmic vesicle membrane#GO:0030659 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG113500|UniProtKB=T1EFT0 T1EFT0 20195432 PTHR45623:SF17 CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED ATP-dependent activity, acting on DNA#GO:0008094;nucleic acid binding#GO:0003676;binding#GO:0005488;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887;histone binding#GO:0042393;pyrophosphatase activity#GO:0016462;ATP-dependent activity#GO:0140657;chromatin binding#GO:0003682;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity, acting on DNA#GO:0140097;protein-containing complex binding#GO:0044877 cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;protein-DNA complex organization#GO:0071824;cellular component organization#GO:0016043;cellular process#GO:0009987;chromatin remodeling#GO:0006338;protein-containing complex organization#GO:0043933 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG73271|UniProtKB=T1G1C4 T1G1C4 20214872 PTHR45677:SF10 GLUTAMATE DECARBOXYLASE-RELATED GLUTAMATE DECARBOXYLASE lyase activity#GO:0016829;carboxy-lyase activity#GO:0016831;carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;amino acid biosynthetic process#GO:0008652;small molecule biosynthetic process#GO:0044283;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 decarboxylase#PC00089 Gamma-aminobutyric acid synthesis#P04384>Glutamate decarboxylase#P04482 HELRO|EnsemblGenome=HelroG193781|UniProtKB=T1FVC6 T1FVC6 20212772 PTHR12949:SF0 RNA POLYMERASE III DNA DIRECTED -RELATED DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;nuclear DNA-directed RNA polymerase complex#GO:0055029;RNA polymerase III complex#GO:0005666;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG73260|UniProtKB=T1G1C2 T1G1C2 20214870 PTHR10954:SF7 RIBONUCLEASE H2 SUBUNIT A RIBONUCLEASE H2 SUBUNIT A catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;mismatch repair#GO:0006298;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;organic substance catabolic process#GO:1901575;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;aromatic compound catabolic process#GO:0019439;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;cellular response to stress#GO:0033554;DNA replication#GO:0006260;DNA metabolic process#GO:0006259 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;catalytic complex#GO:1902494 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG169996|UniProtKB=T1F2I4 T1F2I4 20203034 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184206|UniProtKB=T1FKR6 T1FKR6 20209415 PTHR24408:SF58 ZINC FINGER PROTEIN TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG182030|UniProtKB=T1FHM0 T1FHM0 20208319 PTHR45784:SF5 C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED HELRO|EnsemblGenome=HelroG151879|UniProtKB=T1EKM4 T1EKM4 20197124 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED single-stranded RNA binding#GO:0003727;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;poly(A) binding#GO:0008143;binding#GO:0005488;organic cyclic compound binding#GO:0097159 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG158356|UniProtKB=T1EMP4 T1EMP4 20197844 PTHR21321:SF1 PNAS-3 RELATED EXOSOME COMPLEX COMPONENT RRP40 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159 negative regulation of gene expression#GO:0010629;tRNA metabolic process#GO:0006399;cellular component biogenesis#GO:0044085;regulation of catabolic process#GO:0009894;heterocycle catabolic process#GO:0046700;regulation of nitrogen compound metabolic process#GO:0051171;rRNA processing#GO:0006364;positive regulation of cellular metabolic process#GO:0031325;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA destabilization#GO:0050779;modification-dependent macromolecule catabolic process#GO:0043632;regulation of biological process#GO:0050789;ncRNA metabolic process#GO:0034660;mRNA metabolic process#GO:0016071;regulation of biological quality#GO:0065008;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;snRNA 3'-end processing#GO:0034472;ribosome biogenesis#GO:0042254;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;cellular component organization or biogenesis#GO:0071840;positive regulation of mRNA catabolic process#GO:0061014;regulation of cellular process#GO:0050794;rRNA metabolic process#GO:0016072;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of catabolic process#GO:0009896;mRNA destabilization#GO:0061157;nucleobase-containing compound catabolic process#GO:0034655;polyadenylation-dependent ncRNA catabolic process#GO:0043634;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323;positive regulation of nitrogen compound metabolic process#GO:0051173;cellular aromatic compound metabolic process#GO:0006725;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of mRNA stability#GO:0043488;regulation of mRNA catabolic process#GO:0061013;RNA metabolic process#GO:0016070;positive regulation of cellular catabolic process#GO:0031331;RNA processing#GO:0006396;biosynthetic process#GO:0009058;cellular nitrogen compound catabolic process#GO:0044270;positive regulation of metabolic process#GO:0009893;organic cyclic compound metabolic process#GO:1901360;mRNA catabolic process#GO:0006402;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;snRNA processing#GO:0016180;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;maturation of 5.8S rRNA#GO:0000460;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;positive regulation of mRNA metabolic process#GO:1903313;heterocycle metabolic process#GO:0046483;snRNA metabolic process#GO:0016073;macromolecule biosynthetic process#GO:0009059;negative regulation of biosynthetic process#GO:0009890;RNA 3'-end processing#GO:0031123;cellular biosynthetic process#GO:0044249;nuclear-transcribed mRNA catabolic process#GO:0000956;organic substance biosynthetic process#GO:1901576;regulation of cellular catabolic process#GO:0031329;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;regulation of cellular biosynthetic process#GO:0031326;aromatic compound catabolic process#GO:0019439;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;ribonucleoprotein complex biogenesis#GO:0022613;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;positive regulation of RNA metabolic process#GO:0051254 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513;exosome (RNase complex)#GO:0000178 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG136402|UniProtKB=T1EID9 T1EID9 20196339 PTHR24247:SF265 5-HYDROXYTRYPTAMINE RECEPTOR MUSCARINIC ACETYLCHOLINE RECEPTOR DM1 signaling receptor activity#GO:0038023;G protein-coupled amine receptor activity#GO:0008227;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 response to organic substance#GO:0010033;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to nitrogen compound#GO:1901699;response to nitrogen compound#GO:1901698;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to oxygen-containing compound#GO:1901701;chemical synaptic transmission#GO:0007268;response to chemical#GO:0042221;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;synaptic signaling#GO:0099536;G protein-coupled receptor signaling pathway#GO:0007186;cell-cell signaling#GO:0007267;signaling#GO:0023052;acetylcholine receptor signaling pathway#GO:0095500 synapse#GO:0045202;somatodendritic compartment#GO:0036477;neuron projection#GO:0043005;cell junction#GO:0030054;dendrite#GO:0030425;cell projection#GO:0042995;cell periphery#GO:0071944;dendritic tree#GO:0097447;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GqPCR#P00730 HELRO|EnsemblGenome=HelroG182840|UniProtKB=T1FIU5 T1FIU5 20208744 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG164080|UniProtKB=T1EUW2 T1EUW2 20200362 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166546|UniProtKB=T1EY83 T1EY83 20201533 PTHR10504:SF131 BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED BPI2 DOMAIN-CONTAINING PROTEIN defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG62884|UniProtKB=T1FX66 T1FX66 20213414 PTHR24406:SF8 TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED FI01110P-RELATED nucleic acid binding#GO:0003676;protein-containing complex binding#GO:0044877;chromatin DNA binding#GO:0031490;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG191305|UniProtKB=T1FSV2 T1FSV2 20211899 PTHR10663:SF376 GUANYL-NUCLEOTIDE EXCHANGE FACTOR PH AND SEC7 DOMAIN-CONTAINING PROTEIN guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG98434|UniProtKB=T1G9M7 T1G9M7 20217773 PTHR45755:SF1 FAMILY NOT NAMED PROTON-COUPLED ZINC ANTIPORTER SLC30A5 inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;inorganic cation transmembrane transporter activity#GO:0022890;metal ion transmembrane transporter activity#GO:0046873 inorganic ion homeostasis#GO:0098771;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation transport#GO:0006812;transition metal ion transport#GO:0000041;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG62327|UniProtKB=T1FWZ5 T1FWZ5 20213343 PTHR45961:SF6 IP21249P IP21249P Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG185316|UniProtKB=T1FMN4 T1FMN4 20210083 PTHR11932:SF126 CULLIN CULLIN 4, ISOFORM A enzyme binding#GO:0019899;protein binding#GO:0005515;ubiquitin protein ligase binding#GO:0031625;binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG87050|UniProtKB=T1G6L0 T1G6L0 20216707 PTHR24416:SF620 TYROSINE-PROTEIN KINASE RECEPTOR TYROSINE-PROTEIN KINASE RECEPTOR TORSO signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG193096|UniProtKB=T1FUM5 T1FUM5 20212521 PTHR46061:SF3 THYROTROPIN-RELEASING HORMONE RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 Thyrotropin-releasing hormone receptor signaling pathway#P04394>TRH Receptor#P04580 HELRO|EnsemblGenome=HelroG159906|UniProtKB=T1EPJ4 T1EPJ4 20198494 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG191344|UniProtKB=T1FSW8 T1FSW8 20211915 PTHR11243:SF23 GROWTH FACTOR RECEPTOR-BOUND PROTEIN LD06925P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG168120|UniProtKB=T1F069 T1F069 20202219 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG75983|UniProtKB=T1G2D5 T1G2D5 20215233 PTHR22883:SF452 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular localization#GO:0051641;macromolecule localization#GO:0033036;macromolecule modification#GO:0043412;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;protein palmitoylation#GO:0018345;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;localization within membrane#GO:0051668;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein localization to membrane#GO:0072657;organonitrogen compound biosynthetic process#GO:1901566;protein targeting#GO:0006605;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;protein acylation#GO:0043543;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipoprotein biosynthetic process#GO:0042158;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;lipoprotein metabolic process#GO:0042157 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG184634|UniProtKB=T1FLM7 T1FLM7 20209726 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192487|UniProtKB=T1FU06 T1FU06 20212302 PTHR12431:SF19 SORTING NEXIN 17 AND 27 SORTING NEXIN-27 lipid binding#GO:0008289;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;binding#GO:0005488 endosomal transport#GO:0016197;localization within membrane#GO:0051668;cellular localization#GO:0051641;vesicle-mediated transport to the plasma membrane#GO:0098876;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;endocytic recycling#GO:0032456;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;early endosome#GO:0005769;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185414|UniProtKB=T1FMS5 T1FMS5 20210124 PTHR10502:SF175 ANNEXIN ANNEXIN A13 lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488;phosphatidylserine binding#GO:0001786 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;vesicle membrane#GO:0012506;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG69392|UniProtKB=T1FZU6 T1FZU6 20214344 PTHR10013:SF0 GENERAL VESICULAR TRANSPORT FACTOR P115 GENERAL VESICULAR TRANSPORT FACTOR P115 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG169068|UniProtKB=T1F1C9 T1F1C9 20202629 PTHR24351:SF234 RIBOSOMAL PROTEIN S6 KINASE SERINE_THREONINE-PROTEIN KINASE YPK2_YKR2 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG180770|UniProtKB=T1FG94 T1FG94 20207843 PTHR12388:SF0 MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16 cellular localization#GO:0051641;transmembrane transport#GO:0055085;macromolecule localization#GO:0033036;transport#GO:0006810;protein transmembrane transport#GO:0071806;protein targeting#GO:0006605;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;protein localization to mitochondrion#GO:0070585;cellular process#GO:0009987;protein transmembrane import into intracellular organelle#GO:0044743;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;mitochondrial transport#GO:0006839;organic substance transport#GO:0071702;protein import into mitochondrial matrix#GO:0030150;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein targeting to mitochondrion#GO:0006626;establishment of protein localization to mitochondrion#GO:0072655;protein transport#GO:0015031;protein localization to organelle#GO:0033365;mitochondrial transmembrane transport#GO:1990542 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;TIM23 mitochondrial import inner membrane translocase complex#GO:0005744;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;mitochondrial protein-containing complex#GO:0098798 transporter#PC00227 HELRO|EnsemblGenome=HelroG162725|UniProtKB=T1ET21 T1ET21 20199721 PTHR22880:SF225 FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED protein binding#GO:0005515;histone binding#GO:0042393;binding#GO:0005488;modification-dependent protein binding#GO:0140030 protein-DNA complex organization#GO:0071824;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;cellular component organization#GO:0016043;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG105496|UniProtKB=T1EDV7 T1EDV7 20194759 PTHR45808:SF2 RHO GTPASE-ACTIVATING PROTEIN 68F RHO GTPASE-ACTIVATING PROTEIN 68F nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 GTPase-activating protein#PC00257 VEGF signaling pathway#P00056>Rac#P01421;Angiogenesis#P00005>Rac#P00245;Cytoskeletal regulation by Rho GTPase#P00016>Rho GAPs#P00520;PDGF signaling pathway#P00047>Rho#P01174 HELRO|EnsemblGenome=HelroG193682|UniProtKB=T1FV92 T1FV92 20212738 PTHR12837:SF15 POLY ADP-RIBOSE GLYCOHYDROLASE POLY(ADP-RIBOSE) GLYCOHYDROLASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 ribonucleoside triphosphate metabolic process#GO:0009199;cellular aromatic compound metabolic process#GO:0006725;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative metabolic process#GO:1901135;regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA metabolic process#GO:0051052;regulation of DNA repair#GO:0006282;nucleotide-sugar metabolic process#GO:0009225;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;regulation of cellular response to stress#GO:0080135;organic cyclic compound metabolic process#GO:1901360;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule metabolic process#GO:0043170;purine ribonucleoside triphosphate metabolic process#GO:0009205;regulation of response to stress#GO:0080134;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;regulation of response to stimulus#GO:0048583;regulation of primary metabolic process#GO:0080090;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;purine nucleoside triphosphate metabolic process#GO:0009144;nucleotide metabolic process#GO:0009117;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosidase#PC00110;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG65773|UniProtKB=T1FYC5 T1FYC5 20213823 PTHR12374:SF20 TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED TRANSCRIPTIONAL ADAPTER 2-ALPHA molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;binding#GO:0005488;chromatin binding#GO:0003682;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;protein-containing complex binding#GO:0044877 protein-DNA complex organization#GO:0071824;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;cellular component organization#GO:0016043;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG83813|UniProtKB=T1G5A7 T1G5A7 20216254 PTHR19282:SF431 TETRASPANIN TETRASPANIN 26A, ISOFORM B-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG189501|UniProtKB=T1FR39 T1FR39 20211286 PTHR11227:SF17 WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED AUTOPHAGY-RELATED 18A, ISOFORM E phosphatidylinositol-3-phosphate binding#GO:0032266;phosphatidylinositol bisphosphate binding#GO:1902936;small molecule binding#GO:0036094;binding#GO:0005488;lipid binding#GO:0008289;phosphatidylinositol binding#GO:0035091;anion binding#GO:0043168;ion binding#GO:0043167;phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981 cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;macroautophagy#GO:0016236;macromolecule localization#GO:0033036;macromolecule modification#GO:0043412;protein modification process#GO:0036211;autophagy of mitochondrion#GO:0000422;biosynthetic process#GO:0009058;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;cellular component disassembly#GO:0022411;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;mitochondrion organization#GO:0007005;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organelle disassembly#GO:1903008;lipoprotein biosynthetic process#GO:0042158;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular macromolecule localization#GO:0070727;organelle organization#GO:0006996;autophagosome assembly#GO:0000045;lipoprotein metabolic process#GO:0042157;autophagy#GO:0006914 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;phagophore assembly site#GO:0000407;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;extrinsic component of membrane#GO:0019898 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG145992|UniProtKB=T1EJP5 T1EJP5 20196795 PTHR21493:SF9 CGI-141-RELATED/LIPASE CONTAINING PROTEIN GOLGI TRANSPORT PROTEIN 1-RELATED lipase#PC00143;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG166903|UniProtKB=T1EYQ7 T1EYQ7 20201707 PTHR13817:SF171 TITIN STRETCHIN-MLCK, ISOFORM U structural protein#PC00211 HELRO|EnsemblGenome=HelroG122845|UniProtKB=T1EGW1 T1EGW1 20195811 PTHR14969:SF28 SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG64996|UniProtKB=T1FY23 T1FY23 20213721 PTHR23138:SF179 RAN BINDING PROTEIN NUCLEAR PORE COMPLEX PROTEIN nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 envelope#GO:0031975;cytoplasm#GO:0005737;nuclear pore#GO:0005643;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG179552|UniProtKB=T1FEV2 T1FEV2 20207351 PTHR24543:SF291 MULTICOPPER OXIDASE-RELATED SMOKE ALARM, ISOFORM D oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG107434|UniProtKB=T1EEA5 T1EEA5 20194907 PTHR18884:SF67 SEPTIN SEPTIN-2 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 localization#GO:0051179;cell division#GO:0051301;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;cytoskeleton-dependent cytokinesis#GO:0061640;cell cycle process#GO:0022402;cell cycle#GO:0007049;cellular process#GO:0009987;cytokinesis#GO:0000910;protein localization#GO:0008104 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;cell division site#GO:0032153;cell cortex#GO:0005938;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085 Parkinson disease#P00049>CDCrel-1#P01226 HELRO|EnsemblGenome=HelroG160011|UniProtKB=T1EPN5 T1EPN5 20198535 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183573|UniProtKB=T1FJV1 T1FJV1 20209100 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG130520|UniProtKB=T1EHU0 T1EHU0 20196140 PTHR10027:SF33 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic ion-gated channel activity#GO:0022839;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium-activated cation channel activity#GO:0005227;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG180450|UniProtKB=T1FFX8 T1FFX8 20207727 PTHR46007:SF8 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 C2H2-TYPE DOMAIN-CONTAINING PROTEIN molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;protein binding#GO:0005515;transcription factor binding#GO:0008134 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG189238|UniProtKB=T1FQU7 T1FQU7 20211194 PTHR23320:SF165 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MARVEL DOMAIN-CONTAINING PROTEIN transporter#PC00227 HELRO|EnsemblGenome=HelroG185730|UniProtKB=T1FN76 T1FN76 20210274 PTHR19282:SF252 TETRASPANIN TETRASPANIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG93454|UniProtKB=T1G8V9 T1G8V9 20217506 PTHR10969:SF4 MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 2 lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488 cellular component biogenesis#GO:0044085;macroautophagy#GO:0016236;autophagy of mitochondrion#GO:0000422;response to extracellular stimulus#GO:0009991;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;cellular component disassembly#GO:0022411;cellular response to starvation#GO:0009267;catabolic process#GO:0009056;mitochondrion organization#GO:0007005;autophagosome maturation#GO:0097352;cellular response to extracellular stimulus#GO:0031668;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;cellular component assembly#GO:0022607;cellular response to stimulus#GO:0051716;protein-containing complex disassembly#GO:0032984;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cell communication#GO:0007154;response to nutrient levels#GO:0031667;cellular process#GO:0009987;organelle disassembly#GO:1903008;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to stress#GO:0006950;cellular response to nutrient levels#GO:0031669;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;response to starvation#GO:0042594;cellular response to external stimulus#GO:0071496;autophagosome assembly#GO:0000045;cellular response to stress#GO:0033554;autophagy#GO:0006914 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;autophagosome membrane#GO:0000421;intracellular membrane-bounded organelle#GO:0043231;vacuolar membrane#GO:0005774;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;autophagosome#GO:0005776;intracellular anatomical structure#GO:0005622 non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG193367|UniProtKB=T1FUX3 T1FUX3 20212619 PTHR36911:SF3 LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN-RELATED GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 4-RELATED HELRO|EnsemblGenome=HelroG165351|UniProtKB=T1EWM3 T1EWM3 20200973 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175268|UniProtKB=T1F928 T1F928 20205327 PTHR21580:SF28 SHIPPO-1-RELATED BOREALIN N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED structural protein#PC00211 HELRO|EnsemblGenome=HelroG64261|UniProtKB=T1FXR9 T1FXR9 20213617 PTHR12884:SF0 60S RIBOSOMAL PROTEIN L29 60S RIBOSOMAL PROTEIN L29 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cytoplasmic translation#GO:0002181;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG188435|UniProtKB=T1FPZ5 T1FPZ5 20210892 PTHR13029:SF18 FAMILY NOT NAMED MYELIN REGULATORY FACTOR HOMOLOG 1 sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;gene expression#GO:0010467;regulation of RNA biosynthetic process#GO:2001141;biosynthetic process#GO:0009058;protein processing#GO:0016485;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;proteolysis#GO:0006508;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;protein metabolic process#GO:0019538;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;regulation of DNA-templated transcription#GO:0006355;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;positive regulation of cellular biosynthetic process#GO:0031328;organic substance biosynthetic process#GO:1901576;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG188524|UniProtKB=T1FQ32 T1FQ32 20210929 PTHR48105:SF21 THIOREDOXIN REDUCTASE 1-RELATED-RELATED THIOREDOXIN REDUCTASE 2, MITOCHONDRIAL protein-disulfide reductase activity#GO:0015035;disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;antioxidant activity#GO:0016209;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 homeostatic process#GO:0042592;cellular homeostasis#GO:0019725 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 reductase#PC00198;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG120735|UniProtKB=T1EGQ5 T1EGQ5 20195755 PTHR11660:SF57 SOLUTE CARRIER FAMILY 40 MEMBER SOLUTE CARRIER FAMILY 40 MEMBER secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG172833|UniProtKB=T1F5Z6 T1F5Z6 20204245 PTHR11467:SF36 HISTONE H1 HISTONE 24-RELATED nucleosome binding#GO:0031491;nucleic acid binding#GO:0003676;chromatin DNA binding#GO:0031490;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;protein-containing complex binding#GO:0044877 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA metabolic process#GO:0051052;chromosome condensation#GO:0030261;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;cellular process#GO:0009987;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;regulation of macromolecule metabolic process#GO:0060255;organelle organization#GO:0006996;chromosome organization#GO:0051276;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA recombination#GO:0045910;negative regulation of DNA metabolic process#GO:0051053;regulation of DNA recombination#GO:0000018;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG168369|UniProtKB=T1F0H7 T1F0H7 20202327 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG180635|UniProtKB=T1FG39 T1FG39 20207788 PTHR48012:SF2 STERILE20-LIKE KINASE, ISOFORM B-RELATED STERILE20-LIKE KINASE, ISOFORM B transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG189589|UniProtKB=T1FR64 T1FR64 20211311 PTHR11339:SF409 EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED SUBFAMILY NOT NAMED external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG132363|UniProtKB=T1EHY1 T1EHY1 20196181 PTHR24346:SF49 MAP/MICROTUBULE AFFINITY-REGULATING KINASE NIM1 SERINE_THREONINE PROTEIN KINASE transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;microtubule cytoskeleton organization#GO:0000226;cell communication#GO:0007154;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;regulation of cellular process#GO:0050794;organelle organization#GO:0006996;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;intracellular signal transduction#GO:0035556;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG190496|UniProtKB=T1FS15 T1FS15 20211612 PTHR10766:SF176 TRANSMEMBRANE 9 SUPERFAMILY PROTEIN TRANSMEMBRANE 9 SUPERFAMILY MEMBER localization#GO:0051179;localization within membrane#GO:0051668;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;cellular process#GO:0009987;protein localization#GO:0008104 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG78299|UniProtKB=T1G3A6 T1G3A6 20215554 PTHR23405:SF5 MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED THO COMPLEX SUBUNIT 7 HOMOLOG mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;mRNA transport#GO:0051028;RNA localization#GO:0006403;localization#GO:0051179;organic substance transport#GO:0071702;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;THO complex#GO:0000347;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;transcription export complex#GO:0000346;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG158207|UniProtKB=T1EMK6 T1EMK6 20197806 PTHR43194:SF2 HYDROLASE ALPHA/BETA FOLD FAMILY PEROXISOMAL MEMBRANE PROTEIN LPX1 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG185679|UniProtKB=T1FN49 T1FN49 20210247 PTHR10281:SF1 MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED VACUOLE MEMBRANE PROTEIN 1 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG93221|UniProtKB=T1G8U5 T1G8U5 20217492 PTHR23188:SF12 RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG basal RNA polymerase II transcription machinery binding#GO:0001099;RNA polymerase binding#GO:0070063;binding#GO:0005488;chromatin binding#GO:0003682;RNA polymerase core enzyme binding#GO:0043175;RNA polymerase II complex binding#GO:0000993;enzyme binding#GO:0019899;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;basal transcription machinery binding#GO:0001098 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;transcription elongation factor complex#GO:0008023;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase II, holoenzyme#GO:0016591;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;Cdc73/Paf1 complex#GO:0016593;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG108743|UniProtKB=T1EEM1 T1EEM1 20195023 PTHR12447:SF25 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13C cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG100124|UniProtKB=T1ECY7 T1ECY7 20194439 PTHR12661:SF5 PETER PAN-RELATED SUPPRESSOR OF SWI4 1 HOMOLOG nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159;rRNA binding#GO:0019843 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;organelle assembly#GO:0070925;protein-RNA complex assembly#GO:0022618;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;ribosomal large subunit assembly#GO:0000027;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;protein-RNA complex organization#GO:0071826;non-membrane-bounded organelle assembly#GO:0140694 ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;preribosome, large subunit precursor#GO:0030687;protein-containing complex#GO:0032991 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG66807|UniProtKB=T1FYR1 T1FYR1 20213959 PTHR11830:SF3 40S RIBOSOMAL PROTEIN S3A CYLINDROMATOSIS, ISOFORM D cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein K63-linked deubiquitination#GO:0070536;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG193635|UniProtKB=T1FV78 T1FV78 20212724 PTHR44390:SF1 CENTROSOMAL PROTEIN OF 41 KDA CENTROSOMAL PROTEIN OF 41 KDA organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cilium#GO:0005929;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG131091|UniProtKB=T1EHV2 T1EHV2 20196152 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG193180|UniProtKB=T1FUP9 T1FUP9 20212545 PTHR23074:SF83 AAA DOMAIN-CONTAINING VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG69372|UniProtKB=T1FZU1 T1FZU1 20214339 PTHR24115:SF802 KINESIN-RELATED KINESIN-LIKE PROTEIN UNC-104 pyrophosphatase activity#GO:0016462;cytoskeletal protein binding#GO:0008092;microtubule motor activity#GO:0003777;tubulin binding#GO:0015631;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;cytoskeletal motor activity#GO:0003774;microtubule binding#GO:0008017;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 vesicle transport along microtubule#GO:0047496;cellular localization#GO:0051641;organelle localization#GO:0051640;vesicle localization#GO:0051648;transport#GO:0006810;microtubule-based movement#GO:0007018;cellular process#GO:0009987;transport along microtubule#GO:0010970;localization#GO:0051179;microtubule-based transport#GO:0099111;establishment of localization#GO:0051234;microtubule-based process#GO:0007017;establishment of vesicle localization#GO:0051650;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;organelle transport along microtubule#GO:0072384;establishment of organelle localization#GO:0051656;vesicle cytoskeletal trafficking#GO:0099518 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;microtubule associated complex#GO:0005875;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG77621|UniProtKB=T1G310 T1G310 20215458 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG165465|UniProtKB=T1EWU6 T1EWU6 20201046 PTHR36191:SF1 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG89107|UniProtKB=T1G788 T1G788 20216935 PTHR10075:SF100 BASIGIN RELATED FASCICLIN-2 cell adhesion molecule binding#GO:0050839;cell-cell adhesion mediator activity#GO:0098632;protein binding#GO:0005515;binding#GO:0005488 neuron projection guidance#GO:0097485;cell recognition#GO:0008037;neurogenesis#GO:0022008;cell projection organization#GO:0030030;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;axonogenesis#GO:0007409;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156;cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cell morphogenesis#GO:0000902;cellular process#GO:0009987;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure development#GO:0048856;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;axon#GO:0030424 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG77983|UniProtKB=T1G360 T1G360 20215508 PTHR15599:SF1 RTDR1 RADIAL SPOKE HEAD 14 HOMOLOG HELRO|EnsemblGenome=HelroG65256|UniProtKB=T1FY51 T1FY51 20213749 PTHR11938:SF133 FAD NADPH DEHYDROGENASE/OXIDOREDUCTASE GLUTAMATE SYNTHASE (NADH) oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 dicarboxylic acid metabolic process#GO:0043648;proteinogenic amino acid biosynthetic process#GO:0170038;response to extracellular stimulus#GO:0009991;biosynthetic process#GO:0009058;cellular homeostasis#GO:0019725;carboxylic acid biosynthetic process#GO:0046394;nitrogen compound metabolic process#GO:0006807;glutamate metabolic process#GO:0006536;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;L-amino acid metabolic process#GO:0170033;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;homeostatic process#GO:0042592;cellular biosynthetic process#GO:0044249;response to nutrient levels#GO:0031667;organic substance biosynthetic process#GO:1901576;intracellular chemical homeostasis#GO:0055082;cellular process#GO:0009987;chemical homeostasis#GO:0048878;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;response to external stimulus#GO:0009605;response to stimulus#GO:0050896;alpha-amino acid biosynthetic process#GO:1901607;L-amino acid biosynthetic process#GO:0170034;small molecule biosynthetic process#GO:0044283;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG164197|UniProtKB=T1EV31 T1EV31 20200431 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG173995|UniProtKB=T1F7G6 T1F7G6 20204765 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG156600|UniProtKB=T1ELY9 T1ELY9 20197589 PTHR24072:SF192 RHO FAMILY GTPASE CDC42 HOMOLOG GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;enzyme binding#GO:0019899;ribonucleoside triphosphate phosphatase activity#GO:0017111;kinase binding#GO:0019900;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817;heterocyclic compound binding#GO:1901363;protein kinase binding#GO:0019901;anion binding#GO:0043168;ion binding#GO:0043167 small GTPase#PC00208 TGF-beta signaling pathway#P00052>Ras-GDP#P01291;Huntington disease#P00029>Rac#P00775;Cytoskeletal regulation by Rho GTPase#P00016>Cdc42#P00515;Ras Pathway#P04393>Cdc42#P04569;p38 MAPK pathway#P05918>Cdc42#P06041;TGF-beta signaling pathway#P00052>Ras-GTP#P01280;Axon guidance mediated by netrin#P00009>cdc42#P00364;Integrin signalling pathway#P00034>Cdc42#P00938;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Cdc42#P00834;Axon guidance mediated by Slit/Robo#P00008>Cdc42#P00349;FGF signaling pathway#P00021>Rac#P00645 HELRO|EnsemblGenome=HelroG83547|UniProtKB=T1G570 T1G570 20216218 PTHR45782:SF4 MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1 MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;translation#GO:0006412;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG170182|UniProtKB=T1F2R6 T1F2R6 20203115 PTHR13278:SF0 ZINC FINGER PROTEIN 830 ZINC FINGER PROTEIN 830 cellular aromatic compound metabolic process#GO:0006725;negative regulation of biological process#GO:0048519;signal transduction#GO:0007165;DNA damage checkpoint signaling#GO:0000077;mitotic cell cycle checkpoint signaling#GO:0007093;cell cycle process#GO:0022402;negative regulation of cell cycle process#GO:0010948;nucleobase-containing compound metabolic process#GO:0006139;mitotic cell cycle process#GO:1903047;regulation of biological process#GO:0050789;cell cycle checkpoint signaling#GO:0000075;negative regulation of mitotic cell cycle phase transition#GO:1901991;DNA damage response#GO:0006974;mitotic cell cycle#GO:0000278;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;signal transduction in response to DNA damage#GO:0042770;DNA-templated DNA replication#GO:0006261;mitotic DNA replication checkpoint signaling#GO:0033314;intracellular signal transduction#GO:0035556;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;cell cycle DNA replication#GO:0044786;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;nuclear DNA replication#GO:0033260;cellular response to stimulus#GO:0051716;regulation of cell cycle G2/M phase transition#GO:1902749;negative regulation of cell cycle G2/M phase transition#GO:1902750;regulation of mitotic cell cycle phase transition#GO:1901990;macromolecule metabolic process#GO:0043170;negative regulation of cell cycle#GO:0045786;regulation of cell cycle phase transition#GO:1901987;negative regulation of cell cycle phase transition#GO:1901988;cellular metabolic process#GO:0044237;cell communication#GO:0007154;negative regulation of mitotic cell cycle#GO:0045930;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;regulation of cell cycle process#GO:0010564;response to stimulus#GO:0050896;DNA integrity checkpoint signaling#GO:0031570;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;DNA replication checkpoint signaling#GO:0000076;regulation of cellular process#GO:0050794;mitotic G2/M transition checkpoint#GO:0044818;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of G2/M transition of mitotic cell cycle#GO:0010389;mitotic DNA integrity checkpoint signaling#GO:0044774;cellular response to stress#GO:0033554;DNA replication#GO:0006260;mitotic DNA damage checkpoint signaling#GO:0044773;regulation of mitotic cell cycle#GO:0007346;DNA metabolic process#GO:0006259 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG179844|UniProtKB=T1FF74 T1FF74 20207473 PTHR12271:SF127 POLY A POLYMERASE CID PAP -RELATED SPECKLE TARGETED PIP5K1A-REGULATED POLY(A) POLYMERASE adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 nucleotidyltransferase#PC00174 HELRO|EnsemblGenome=HelroG109375|UniProtKB=T1EES9 T1EES9 20195081 PTHR45819:SF5 CENTAURIN-GAMMA-1A CENTAURIN-GAMMA-1A GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;catalytic activity#GO:0003824;molecular function regulator activity#GO:0098772;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;enzyme activator activity#GO:0008047;ribonucleoside triphosphate phosphatase activity#GO:0017111;enzyme regulator activity#GO:0030234 regulation of GTPase activity#GO:0043087;regulation of molecular function#GO:0065009;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;activation of GTPase activity#GO:0090630;biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG175341|UniProtKB=T1F962 T1F962 20205361 PTHR21041:SF17 DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN E3 UBIQUITIN-PROTEIN LIGASE DCST1 HELRO|EnsemblGenome=HelroG146486|UniProtKB=T1EJS5 T1EJS5 20196825 PTHR23050:SF518 CALCIUM BINDING PROTEIN AT16150P-RELATED cation binding#GO:0043169;small molecule binding#GO:0036094;molecular function regulator activity#GO:0098772;binding#GO:0005488;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;enzyme regulator activity#GO:0030234 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061 B cell activation#P00010>Calmodulin#P00375;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Calmodulin#P00755;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716;T cell activation#P00053>Calmodulin#P01305 HELRO|EnsemblGenome=HelroG173488|UniProtKB=T1F6V7 T1F6V7 20204556 PTHR25462:SF291 BONUS, ISOFORM C-RELATED E3 UBIQUITIN-PROTEIN LIGASE TRIM45 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG175735|UniProtKB=T1F9L6 T1F9L6 20205515 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG115787|UniProtKB=T1EGA5 T1EGA5 20195607 PTHR22957:SF645 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN LD27216P nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;activation of GTPase activity#GO:0090630;biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG136356|UniProtKB=T1EID6 T1EID6 20196336 PTHR23235:SF153 KRUEPPEL-LIKE TRANSCRIPTION FACTOR C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG85597|UniProtKB=T1G603 T1G603 20216500 PTHR11453:SF36 ANION EXCHANGE PROTEIN ANION EXCHANGE PROTEIN secondary active transmembrane transporter activity#GO:0015291;inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;symporter activity#GO:0015293;active monoatomic ion transmembrane transporter activity#GO:0022853;solute:sodium symporter activity#GO:0015370;organic anion transmembrane transporter activity#GO:0008514;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;inorganic cation transmembrane transporter activity#GO:0022890;transporter activity#GO:0005215;solute:monoatomic cation symporter activity#GO:0015294 regulation of intracellular pH#GO:0051453;transmembrane transport#GO:0055085;organic anion transport#GO:0015711;transport#GO:0006810;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;regulation of pH#GO:0006885;organic substance transport#GO:0071702;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;intracellular monoatomic cation homeostasis#GO:0030003;biological regulation#GO:0065007;intracellular monoatomic ion homeostasis#GO:0006873;regulation of cellular pH#GO:0030641 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG184201|UniProtKB=T1FKR3 T1FKR3 20209412 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185204|UniProtKB=T1FMI2 T1FMI2 20210031 PTHR12304:SF4 INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE URIDINE NUCLEOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;nucleoside metabolic process#GO:0009116;glycosyl compound catabolic process#GO:1901658;carbohydrate derivative metabolic process#GO:1901135;heterocycle catabolic process#GO:0046700;organonitrogen compound catabolic process#GO:1901565;nucleobase-containing compound metabolic process#GO:0006139;purine-containing compound catabolic process#GO:0072523;cellular nitrogen compound catabolic process#GO:0044270;organic cyclic compound metabolic process#GO:1901360;purine nucleoside metabolic process#GO:0042278;nitrogen compound metabolic process#GO:0006807;purine-containing compound metabolic process#GO:0072521;catabolic process#GO:0009056;nucleoside catabolic process#GO:0009164;organic substance catabolic process#GO:1901575;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248;heterocycle metabolic process#GO:0046483;carbohydrate derivative catabolic process#GO:1901136;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;purine nucleoside catabolic process#GO:0006152;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;small molecule catabolic process#GO:0044282;aromatic compound catabolic process#GO:0019439;nucleobase-containing small molecule catabolic process#GO:0034656;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;glycosyl compound metabolic process#GO:1901657;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG194832|UniProtKB=T1FWG7 T1FWG7 20213162 PTHR45854:SF3 ASAP FAMILY MEMBER ARFGAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG75529|UniProtKB=T1G262 T1G262 20215160 PTHR12673:SF267 FACIOGENITAL DYSPLASIA PROTEIN PROTEIN CBG10230 nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG188525|UniProtKB=T1FQ33 T1FQ33 20210930 PTHR45615:SF40 MYOSIN HEAVY CHAIN, NON-MUSCLE MYOSIN HEAVY CHAIN, NON-MUSCLE microfilament motor activity#GO:0000146;cytoskeletal protein binding#GO:0008092;ATP-dependent activity#GO:0140657;binding#GO:0005488;actin filament binding#GO:0051015;cytoskeletal motor activity#GO:0003774;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779 supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;supramolecular fiber#GO:0099512;supramolecular polymer#GO:0099081;myosin complex#GO:0016459;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Myosin#P00867;Cytoskeletal regulation by Rho GTPase#P00016>Myosin#P00522;Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG151843|UniProtKB=T1EKM3 T1EKM3 20197123 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG168920|UniProtKB=T1F147 T1F147 20202547 PTHR21522:SF32 PROTON CHANNEL OTOP OTOPETRIN-2 monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078;proton channel activity#GO:0015252;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;proton transmembrane transport#GO:1902600;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG70378|UniProtKB=T1G058 T1G058 20214456 PTHR18929:SF132 PROTEIN DISULFIDE ISOMERASE PROTEIN DISULFIDE-ISOMERASE A3 isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;protein disulfide isomerase activity#GO:0003756 cellular response to stimulus#GO:0051716;macromolecule biosynthetic process#GO:0009059;response to endoplasmic reticulum stress#GO:0034976;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;response to stress#GO:0006950;protein folding#GO:0006457;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG107353|UniProtKB=T1EE99 T1EE99 20194901 PTHR24093:SF369 CATION TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE calcium ion transmembrane transporter activity#GO:0015085;inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;P-type ion transporter activity#GO:0015662;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075 intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG104178|UniProtKB=T1EDK1 T1EDK1 20194653 PTHR23055:SF167 CALCIUM BINDING PROTEINS EF-HAND DOMAIN-CONTAINING PROTEIN cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG163145|UniProtKB=T1ETQ3 T1ETQ3 20199953 PTHR19134:SF536 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE DOMAIN-CONTAINING PROTEIN hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG68869|UniProtKB=T1FZK7 T1FZK7 20214255 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166077|UniProtKB=T1EXP9 T1EXP9 20201349 PTHR13526:SF8 TRANSCRIPTION FACTOR SPT20 HOMOLOG TRANSCRIPTION FACTOR SPT20 HOMOLOG molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 SAGA-type complex#GO:0070461;peptidase complex#GO:1905368;histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;chromosome#GO:0005694;SAGA complex#GO:0000124 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG163757|UniProtKB=T1EUF4 T1EUF4 20200204 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG67489|UniProtKB=T1FZ16 T1FZ16 20214064 PTHR24329:SF543 HOMEOBOX PROTEIN ARISTALESS FI01017P-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG170715|UniProtKB=T1F3C5 T1F3C5 20203324 PTHR13132:SF29 ALPHA- 1,6 -FUCOSYLTRANSFERASE ALPHA-(1,6)-FUCOSYLTRANSFERASE transferase activity#GO:0016740;fucosyltransferase activity#GO:0008417;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein glycosylation#GO:0006486;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;protein metabolic process#GO:0019538;glycosylation#GO:0070085;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 glycosyltransferase#PC00111 Notch signaling pathway#P00045>Neurotic#P01115 HELRO|EnsemblGenome=HelroG191977|UniProtKB=T1FTH3 T1FTH3 20212120 PTHR11890:SF44 INTERLEUKIN-1 RECEPTOR FAMILY MEMBER X-LINKED INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN-LIKE 2 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG193210|UniProtKB=T1FUR4 T1FUR4 20212560 PTHR22775:SF3 SORTING NEXIN SORTING NEXIN-13 lipid binding#GO:0008289;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;binding#GO:0005488 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS-PX1#P00706 HELRO|EnsemblGenome=HelroG169094|UniProtKB=T1F1D9 T1F1D9 20202639 PTHR13866:SF14 SPARC OSTEONECTIN BM-40 cation binding#GO:0043169;extracellular matrix binding#GO:0050840;small molecule binding#GO:0036094;binding#GO:0005488;collagen binding#GO:0005518;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;protein-containing complex binding#GO:0044877;ion binding#GO:0043167 anatomical structure development#GO:0048856;developmental process#GO:0032502 extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 extracellular matrix glycoprotein#PC00100 HELRO|EnsemblGenome=HelroG188556|UniProtKB=T1FQ42 T1FQ42 20210939 PTHR46297:SF1 ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription repressor activity#GO:0001217;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG176568|UniProtKB=T1FAN7 T1FAN7 20205886 PTHR16021:SF23 MANSC DOMAIN CONTAINING PROTEIN 1 FI18411P1-RELATED HELRO|EnsemblGenome=HelroG87291|UniProtKB=T1G6N7 T1G6N7 20216734 PTHR10026:SF51 CYCLIN CYCLIN-T protein kinase activator activity#GO:0030295;protein kinase regulator activity#GO:0019887;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;kinase regulator activity#GO:0019207;kinase activator activity#GO:0019209 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of DNA-templated transcription, elongation#GO:0032786;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;regulation of DNA-templated transcription elongation#GO:0032784;regulation of DNA-templated transcription#GO:0006355;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;transcription elongation factor complex#GO:0008023;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 kinase activator#PC00138 HELRO|EnsemblGenome=HelroG155669|UniProtKB=T1ELK2 T1ELK2 20197452 PTHR11006:SF124 PROTEIN ARGININE N-METHYLTRANSFERASE ARGININE METHYLTRANSFERASE 1-RELATED N-methyltransferase activity#GO:0008170;histone modifying activity#GO:0140993;transferase activity#GO:0016740;catalytic activity#GO:0003824;histone methyltransferase activity#GO:0042054;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a protein#GO:0140096;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein methyltransferase activity#GO:0008276 protein-DNA complex organization#GO:0071824;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;cellular component organization#GO:0016043;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;methylation#GO:0032259;macromolecule methylation#GO:0043414;nitrogen compound metabolic process#GO:0006807;protein-containing complex organization#GO:0043933;chromatin organization#GO:0006325;protein metabolic process#GO:0019538;chromatin remodeling#GO:0006338;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG160169|UniProtKB=T1EPX0 T1EPX0 20198620 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178799|UniProtKB=T1FDR2 T1FDR2 20206961 PTHR21191:SF16 AQUAPORIN AQUAPORIN passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;channel activity#GO:0015267 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG76269|UniProtKB=T1G2H6 T1G2H6 20215274 PTHR18966:SF422 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED signaling receptor activity#GO:0038023;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;ligand-gated channel activity#GO:0022834 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019 HELRO|EnsemblGenome=HelroG153263|UniProtKB=T1EL20 T1EL20 20197270 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG181144|UniProtKB=T1FGN8 T1FGN8 20207987 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG72617|UniProtKB=T1G126 T1G126 20214774 PTHR12297:SF18 HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED HIG1 DOMAIN FAMILY MEMBER 2A cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;mitochondrion organization#GO:0007005;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG91678|UniProtKB=T1G877 T1G877 20217274 PTHR46491:SF3 CDGSH IRON SULFUR DOMAIN PROTEIN HOMOLOG CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL small molecule binding#GO:0036094;iron-sulfur cluster binding#GO:0051536;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG63970|UniProtKB=T1FXM9 T1FXM9 20213577 PTHR10356:SF0 ALLOGRAFT INFLAMMATORY FACTOR-1 CALCIUM-BINDING PROTEIN B cation binding#GO:0043169;cytoskeletal protein binding#GO:0008092;small molecule binding#GO:0036094;binding#GO:0005488;actin filament binding#GO:0051015;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;ion binding#GO:0043167;actin binding#GO:0003779 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cell projection organization#GO:0030030;actin filament bundle assembly#GO:0051017;cellular component organization#GO:0016043;actin filament bundle organization#GO:0061572;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;plasma membrane bounded cell projection assembly#GO:0120031 supramolecular complex#GO:0099080;leading edge membrane#GO:0031256;cell projection membrane#GO:0031253;supramolecular polymer#GO:0099081;cell periphery#GO:0071944;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;organelle#GO:0043226;actin filament#GO:0005884;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cell leading edge#GO:0031252;non-membrane-bounded organelle#GO:0043228;ruffle membrane#GO:0032587;actin cytoskeleton#GO:0015629;ruffle#GO:0001726;plasma membrane region#GO:0098590;cell projection#GO:0042995;cytoskeleton#GO:0005856;plasma membrane#GO:0005886 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG152911|UniProtKB=T1EKY1 T1EKY1 20197231 PTHR21196:SF1 U7 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM10 U7 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM10 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;snRNA binding#GO:0017069;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;mRNA 3'-end processing#GO:0031124;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mRNA processing#GO:0006397;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear body#GO:0016604;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981 HELRO|EnsemblGenome=HelroG193795|UniProtKB=T1FVD0 T1FVD0 20212776 PTHR13159:SF0 RADIAL SPOKEHEAD-RELATED RADIAL SPOKE HEAD 6 HOMOLOG A cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;microtubule cytoskeleton organization#GO:0000226;microtubule-based movement#GO:0007018;cellular component organization#GO:0016043;axoneme assembly#GO:0035082;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;cilium movement#GO:0003341;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;microtubule bundle formation#GO:0001578;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection assembly#GO:0120031 axoneme#GO:0005930;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;plasma membrane bounded cell projection cytoplasm#GO:0032838;membrane-bounded organelle#GO:0043227;ciliary plasm#GO:0097014;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG159283|UniProtKB=T1ENU1 T1ENU1 20198241 PTHR21567:SF87 CLASP CRESCERIN-LIKE PROTEIN CHE-12 cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule-based process#GO:0007017;organelle organization#GO:0006996 supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cytoplasmic microtubule#GO:0005881;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG72070|UniProtKB=T1G0U9 T1G0U9 20214697 PTHR45738:SF5 POLYPHOSPHOINOSITIDE PHOSPHATASE POLYPHOSPHOINOSITIDE PHOSPHATASE hydrolase activity#GO:0016787;phosphatidylinositol-3,5-bisphosphate phosphatase activity#GO:0106018;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 phospholipid dephosphorylation#GO:0046839;lipid metabolic process#GO:0006629;phosphatidylinositol dephosphorylation#GO:0046856;cellular metabolic process#GO:0044237;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;lipid modification#GO:0030258;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;dephosphorylation#GO:0016311;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG165359|UniProtKB=T1EWM9 T1EWM9 20200979 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG144059|UniProtKB=T1EJD5 T1EJD5 20196685 PTHR43215:SF14 RADIAL SPOKE HEAD 1 HOMOLOG RADIAL SPOKE HEAD 1 HOMOLOG HELRO|EnsemblGenome=HelroG177369|UniProtKB=T1FBK7 T1FBK7 20206206 PTHR45710:SF26 C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 180 RH26557P defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG103011|UniProtKB=T1EDD7 T1EDD7 20194589 PTHR19972:SF10 CALBINDIN CALBINDIN-32 cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;intracellular monoatomic cation homeostasis#GO:0030003;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic ion homeostasis#GO:0006873;cellular homeostasis#GO:0019725;regulation of cytosolic calcium ion concentration#GO:0051480;intracellular chemical homeostasis#GO:0055082;chemical homeostasis#GO:0048878;intracellular calcium ion homeostasis#GO:0006874;monoatomic ion homeostasis#GO:0050801 cytoplasm#GO:0005737;synapse#GO:0045202;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;neuron projection#GO:0043005;cell junction#GO:0030054;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG165856|UniProtKB=T1EXD2 T1EXD2 20201232 PTHR12461:SF53 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED JMJC DOMAIN-CONTAINING PROTEIN protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG75995|UniProtKB=T1G2D7 T1G2D7 20215235 PTHR10068:SF14 BONE MARROW PROTEOGLYCAN CELL WALL ADHESIN EAP1 extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG135638|UniProtKB=T1EI97 T1EI97 20196297 PTHR16301:SF25 IMPACT-RELATED PROTEIN IMPACT cellular response to stimulus#GO:0051716;regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;cellular process#GO:0009987;regulation of translational initiation#GO:0006446;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular biosynthetic process#GO:0031326;response to stress#GO:0006950;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;cellular response to stress#GO:0033554;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG186014|UniProtKB=T1FNJ8 T1FNJ8 20210395 PTHR45683:SF3 MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED MITOCHONDRIAL FOLATE TRANSPORTER_CARRIER amide transmembrane transporter activity#GO:0042887;nucleobase-containing compound transmembrane transporter activity#GO:0015932;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 transmembrane transport#GO:0055085;dicarboxylic acid transport#GO:0006835;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;nitrogen compound transport#GO:0071705;carboxylic acid transport#GO:0046942;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039;mitochondrial transport#GO:0006839;amide transport#GO:0042886;localization#GO:0051179;organic substance transport#GO:0071702;establishment of localization#GO:0051234;vitamin transport#GO:0051180;organic acid transmembrane transport#GO:1903825;mitochondrial transmembrane transport#GO:1990542 transporter#PC00227 HELRO|EnsemblGenome=HelroG100002|UniProtKB=T1ECX9 T1ECX9 20194431 PTHR11006:SF4 PROTEIN ARGININE N-METHYLTRANSFERASE PROTEIN ARGININE N-METHYLTRANSFERASE 7 N-methyltransferase activity#GO:0008170;histone modifying activity#GO:0140993;transferase activity#GO:0016740;catalytic activity#GO:0003824;histone methyltransferase activity#GO:0042054;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a protein#GO:0140096;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein methyltransferase activity#GO:0008276 protein-DNA complex organization#GO:0071824;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular component organization#GO:0016043;peptidyl-amino acid modification#GO:0018193;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;methylation#GO:0032259;macromolecule methylation#GO:0043414;nitrogen compound metabolic process#GO:0006807;protein-containing complex organization#GO:0043933;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185761|UniProtKB=T1FN92 T1FN92 20210290 PTHR12221:SF6 PESCADILLO - RELATED PESCADILLO HOMOLOG nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of LSU-rRNA#GO:0000470;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981;90S preribosome#GO:0030686;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG63244|UniProtKB=T1FXC9 T1FXC9 20213477 PTHR22883:SF147 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular localization#GO:0051641;macromolecule localization#GO:0033036;macromolecule modification#GO:0043412;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;protein palmitoylation#GO:0018345;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;localization within membrane#GO:0051668;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein localization to membrane#GO:0072657;organonitrogen compound biosynthetic process#GO:1901566;protein targeting#GO:0006605;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;protein acylation#GO:0043543;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipoprotein biosynthetic process#GO:0042158;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;lipoprotein metabolic process#GO:0042157 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG63672|UniProtKB=T1FXI9 T1FXI9 20213537 PTHR16023:SF0 TAX1 BINDING PROTEIN-RELATED PROTEIN VAC14 HOMOLOG lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;phosphatidylinositol 3-kinase complex#GO:0005942;catalytic complex#GO:1902494;transferase complex#GO:1990234;vacuolar membrane#GO:0005774;vacuole#GO:0005773;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endosome membrane#GO:0010008;phosphatidylinositol 3-kinase complex, class III#GO:0035032;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;extrinsic component of membrane#GO:0019898;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle membrane#GO:0030659 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG87104|UniProtKB=T1G6L7 T1G6L7 20216714 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG188678|UniProtKB=T1FQ87 T1FQ87 20210984 PTHR14594:SF1 CENTROSOMAL PROTEIN OF 70 KDA CENTROSOMAL PROTEIN OF 70 KDA organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG175765|UniProtKB=T1F9M3 T1F9M3 20205522 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188977|UniProtKB=T1FQI9 T1FQI9 20211086 PTHR23349:SF72 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST HLH54F sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG181580|UniProtKB=T1FH47 T1FH47 20208146 PTHR14754:SF34 TRANSCRIPTION ELONGATION FACTOR A TRICHOHYALIN membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG108353|UniProtKB=T1EEI4 T1EEI4 20194986 PTHR11806:SF0 GLUCOSE INHIBITED DIVISION PROTEIN A PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;flavin adenine dinucleotide binding#GO:0050660;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;ncRNA metabolic process#GO:0034660;tRNA methylation#GO:0030488;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;tRNA wobble uridine modification#GO:0002098;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;methylation#GO:0032259;macromolecule methylation#GO:0043414;RNA methylation#GO:0001510 HELRO|EnsemblGenome=HelroG173159|UniProtKB=T1F6H1 T1F6H1 20204420 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG185030|UniProtKB=T1FMB1 T1FMB1 20209960 PTHR45954:SF1 LD33695P LD33695P nucleoside-triphosphatase regulator activity#GO:0060589;protein binding#GO:0005515;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;binding#GO:0005488;molecular function regulator activity#GO:0098772 establishment or maintenance of cell polarity#GO:0007163;cellular localization#GO:0051641;organelle localization#GO:0051640;establishment of spindle orientation#GO:0051294;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular process#GO:0009987;establishment of spindle localization#GO:0051293;mitotic cell cycle process#GO:1903047;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of mitotic spindle localization#GO:0040001;establishment of mitotic spindle orientation#GO:0000132;establishment of cell polarity#GO:0030010;mitotic cell cycle#GO:0000278;establishment of localization#GO:0051234;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cell cycle#GO:0007049;establishment of localization in cell#GO:0051649;cytoskeleton organization#GO:0007010;establishment of organelle localization#GO:0051656;spindle localization#GO:0051653 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;cell cortex#GO:0005938;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG115766|UniProtKB=T1EGA3 T1EGA3 20195605 PTHR23280:SF34 4.1 G PROTEIN FERM DOMAIN CONTAINING 7 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;actomyosin structure organization#GO:0031032;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG191662|UniProtKB=T1FT69 T1FT69 20212016 PTHR46218:SF4 LASP LIM AND SH3 DOMAIN PROTEIN LASP HELRO|EnsemblGenome=HelroG181874|UniProtKB=T1FHF1 T1FHF1 20208250 PTHR45884:SF2 N-ACETYLTRANSFERASE ECO N-ACETYLTRANSFERASE ECO acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 cellular component organization or biogenesis#GO:0071840;sister chromatid cohesion#GO:0007062;mitotic sister chromatid cohesion#GO:0007064;organelle organization#GO:0006996;chromosome organization#GO:0051276;cell cycle process#GO:0022402;cell cycle#GO:0007049;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG62905|UniProtKB=T1FX72 T1FX72 20213420 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194040|UniProtKB=T1FVL5 T1FVL5 20212861 PTHR13393:SF0 SAM-DEPENDENT METHYLTRANSFERASE RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16 catalytic activity, acting on RNA#GO:0140098;N-methyltransferase activity#GO:0008170;transferase activity#GO:0016740;rRNA (adenine) methyltransferase activity#GO:0016433;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on a rRNA#GO:0140102;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;rRNA methyltransferase activity#GO:0008649;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;RNA methyltransferase activity#GO:0008173 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA modification#GO:0009451;rRNA modification#GO:0000154;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;ribosome biogenesis#GO:0042254;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;rRNA methylation#GO:0031167;nucleic acid metabolic process#GO:0090304;methylation#GO:0032259;macromolecule methylation#GO:0043414;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;rRNA base methylation#GO:0070475;RNA methylation#GO:0001510 methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG187499|UniProtKB=T1FPA2 T1FPA2 20210649 PTHR11699:SF302 ALDEHYDE DEHYDROGENASE-RELATED ALDEHYDE DEHYDROGENASE 2-RELATED oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 dehydrogenase#PC00092;oxidoreductase#PC00176 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HELRO|EnsemblGenome=HelroG67579|UniProtKB=T1FZ25 T1FZ25 20214073 PTHR24393:SF138 ZINC FINGER PROTEIN IP01201P-RELATED DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG160409|UniProtKB=T1EQ78 T1EQ78 20198728 PTHR37162:SF1 HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED BED-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG78824|UniProtKB=T1G3G1 T1G3G1 20215609 PTHR46473:SF10 GH08155P LD45603P-RELATED HELRO|EnsemblGenome=HelroG104268|UniProtKB=T1EDK7 T1EDK7 20194659 PTHR11359:SF0 AMP DEAMINASE AMP DEAMINASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;deaminase activity#GO:0019239;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;purine ribonucleoside monophosphate metabolic process#GO:0009167;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;nucleotide biosynthetic process#GO:0009165;nucleoside monophosphate metabolic process#GO:0009123;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;IMP metabolic process#GO:0046040;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;purine nucleoside monophosphate metabolic process#GO:0009126;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribonucleoside monophosphate metabolic process#GO:0009161;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;IMP biosynthetic process#GO:0006188;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 deaminase#PC00088;hydrolase#PC00121 Purine metabolism#P02769>5'-AMP Deaminase#P03117 HELRO|EnsemblGenome=HelroG145478|UniProtKB=T1EJK4 T1EJK4 20196754 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG69972|UniProtKB=T1G008 T1G008 20214406 PTHR10472:SF1 D-TYROSYL-TRNA TYR DEACYLASE D-AMINOACYL-TRNA DEACYLASE 2 catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787;catalytic activity, acting on RNA#GO:0140098;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 esterase#PC00097;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG71336|UniProtKB=T1G0J8 T1G0J8 20214596 PTHR31826:SF0 NICALIN NICALIN biological regulation#GO:0065007;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;regulation of signaling#GO:0023051 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG177485|UniProtKB=T1FBR9 T1FBR9 20206268 PTHR19303:SF71 TRANSPOSON ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG192902|UniProtKB=T1FUE6 T1FUE6 20212442 PTHR33562:SF28 ATILLA, ISOFORM B-RELATED-RELATED PROTEIN QUIVER HELRO|EnsemblGenome=HelroG185528|UniProtKB=T1FMX7 T1FMX7 20210176 PTHR11105:SF0 CITRATE LYASE SUBUNIT BETA-RELATED CITRAMALYL-COA LYASE, MITOCHONDRIAL lyase#PC00144 Pyruvate metabolism#P02772>Citrate Lyase#P03137 HELRO|EnsemblGenome=HelroG194592|UniProtKB=T1FW83 T1FW83 20213079 PTHR14247:SF8 BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN RAS-GEF DOMAIN-CONTAINING PROTEIN positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of protein phosphorylation#GO:0001934;positive regulation of phosphorylation#GO:0042327;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;positive regulation of phosphorus metabolic process#GO:0010562;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of protein modification process#GO:0031401;positive regulation of cellular process#GO:0048522;regulation of phosphorus metabolic process#GO:0051174;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;positive regulation of protein metabolic process#GO:0051247;positive regulation of phosphate metabolic process#GO:0045937;positive regulation of metabolic process#GO:0009893;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of protein phosphorylation#GO:0001932;biological regulation#GO:0065007;regulation of phosphorylation#GO:0042325;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 HELRO|EnsemblGenome=HelroG159093|UniProtKB=T1ENK8 T1ENK8 20198158 PTHR33748:SF5 PROTEIN CBG04600 GROUND-LIKE DOMAIN-CONTAINING PROTEIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG186595|UniProtKB=T1FP14 T1FP14 20210561 PTHR11668:SF300 SERINE/THREONINE PROTEIN PHOSPHATASE SERINE_THREONINE-PROTEIN PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 Nicotine pharmacodynamics pathway#P06587>PPP1CA#P06602;Dopamine receptor mediated signaling pathway#P05912>Protein Phosphatase-1#P05969 HELRO|EnsemblGenome=HelroG168687|UniProtKB=T1F0V1 T1F0V1 20202451 PTHR24388:SF53 ZINC FINGER PROTEIN CHORION TRANSCRIPTION FACTOR CF2-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG65586|UniProtKB=T1FYA2 T1FYA2 20213800 PTHR22763:SF190 RING ZINC FINGER PROTEIN RING FINGER PROTEIN 24 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG162084|UniProtKB=T1ES84 T1ES84 20199434 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG156422|UniProtKB=T1ELW1 T1ELW1 20197561 PTHR25462:SF285 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG189421|UniProtKB=T1FR18 T1FR18 20211265 PTHR11636:SF5 POU DOMAIN POU DOMAIN MOTIF 3, ISOFORM F sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG90313|UniProtKB=T1G7P2 T1G7P2 20217089 PTHR20884:SF8 GDP-D-GLUCOSE PHOSPHORYLASE 1 GDP-D-GLUCOSE PHOSPHORYLASE 1 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 monosaccharide metabolic process#GO:0005996;hexose metabolic process#GO:0019318;glucose metabolic process#GO:0006006;carbohydrate metabolic process#GO:0005975;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG171357|UniProtKB=T1F461 T1F461 20203610 PTHR33395:SF22 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184296|UniProtKB=T1FKX7 T1FKX7 20209476 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180285|UniProtKB=T1FFP3 T1FFP3 20207642 PTHR24119:SF0 ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6 ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6 nucleotide binding#GO:0000166;carbohydrate derivative binding#GO:0097367;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;amide binding#GO:0033218;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;lipid binding#GO:0008289;ion binding#GO:0043167;anion binding#GO:0043168 HELRO|EnsemblGenome=HelroG172549|UniProtKB=T1F5I0 T1F5I0 20204079 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175877|UniProtKB=T1F9T5 T1F9T5 20205584 PTHR47577:SF2 THAP DOMAIN-CONTAINING PROTEIN 6 THAP DOMAIN CONTAINING 9 HELRO|EnsemblGenome=HelroG62417|UniProtKB=T1FX03 T1FX03 20213351 PTHR12855:SF10 DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;protein-macromolecule adaptor activity#GO:0030674 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;NuA4 histone acetyltransferase complex#GO:0035267;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;non-membrane-bounded organelle#GO:0043228;chromosome#GO:0005694;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;protein-DNA complex#GO:0032993;transferase complex#GO:1990234;INO80-type complex#GO:0097346;intracellular organelle lumen#GO:0070013;ATPase complex#GO:1904949;SWI/SNF superfamily-type complex#GO:0070603;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;histone deacetylase complex#GO:0000118;nuclear lumen#GO:0031981;Swr1 complex#GO:0000812;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG72133|UniProtKB=T1G0W3 T1G0W3 20214711 PTHR11003:SF334 POTASSIUM CHANNEL, SUBFAMILY K FI03418P monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG163387|UniProtKB=T1ETZ7 T1ETZ7 20200047 PTHR43243:SF105 INNER MEMBRANE TRANSPORTER YGJI-RELATED CATIONIC AMINO ACID TRANSPORTER C-TERMINAL DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;establishment of localization#GO:0051234;amino acid transport#GO:0006865;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;nitrogen compound transport#GO:0071705;carboxylic acid transport#GO:0046942 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 amino acid transporter#PC00046;transporter#PC00227 HELRO|EnsemblGenome=HelroG171242|UniProtKB=T1F3Z6 T1F3Z6 20203545 PTHR46302:SF3 DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 1 DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 1 cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;microtubule binding#GO:0008017;tubulin binding#GO:0015631;binding#GO:0005488 biological regulation#GO:0065007;regulation of biological process#GO:0050789;regulation of cell cycle#GO:0051726;regulation of cell division#GO:0051302;regulation of cytokinesis#GO:0032465;regulation of cellular process#GO:0050794;regulation of cell cycle process#GO:0010564 cellular anatomical entity#GO:0110165;midbody#GO:0030496 HELRO|EnsemblGenome=HelroG108960|UniProtKB=T1EEP3 T1EEP3 20195045 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183925|UniProtKB=T1FKB0 T1FKB0 20209259 PTHR21436:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 142 COILED-COIL DOMAIN-CONTAINING PROTEIN 142 HELRO|EnsemblGenome=HelroG158078|UniProtKB=T1EMJ1 T1EMJ1 20197791 PTHR12027:SF77 WNT RELATED PROTEIN WNT-5 molecular function activator activity#GO:0140677;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;protein binding#GO:0005515;cytokine activity#GO:0005125;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;neurogenesis#GO:0022008;developmental process#GO:0032502;multicellular organism development#GO:0007275;cell communication#GO:0007154;cell fate commitment#GO:0045165;cell-cell signaling by wnt#GO:0198738;nervous system development#GO:0007399;cellular process#GO:0009987;regulation of biological process#GO:0050789;system development#GO:0048731;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;cell-cell signaling#GO:0007267;signaling#GO:0023052;canonical Wnt signaling pathway#GO:0060070;Wnt signaling pathway#GO:0016055 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Angiogenesis#P00005>Wnt#P00206;Cadherin signaling pathway#P00012>Wnt#P00474 HELRO|EnsemblGenome=HelroG114944|UniProtKB=T1EG55 T1EG55 20195557 PTHR24256:SF470 TRYPTASE-RELATED INACTIVE CLIP DOMAIN-CONTAINING SERINE PROTEASE A30 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191759|UniProtKB=T1FTA3 T1FTA3 20212050 PTHR11905:SF159 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG170360|UniProtKB=T1F2Y9 T1F2Y9 20203188 PTHR13793:SF107 PHD FINGER PROTEINS BROMODOMAIN-CONTAINING PROTEIN HOMOLOG regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG186124|UniProtKB=T1FNP5 T1FNP5 20210442 PTHR23063:SF2 PHOSPHOLIPID ACYLTRANSFERASE GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 4, ISOFORM D-RELATED acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;O-acyltransferase activity#GO:0008374 lipid metabolic process#GO:0006629;triglyceride metabolic process#GO:0006641;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;acylglycerol metabolic process#GO:0006639;lipid biosynthetic process#GO:0008610;primary metabolic process#GO:0044238;neutral lipid metabolic process#GO:0006638;glycerolipid metabolic process#GO:0046486;triglyceride biosynthetic process#GO:0019432;cellular lipid metabolic process#GO:0044255;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG76198|UniProtKB=T1G2G7 T1G2G7 20215265 PTHR45617:SF172 LEUCINE RICH REPEAT FAMILY PROTEIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN 15-LIKE scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG188972|UniProtKB=T1FQI8 T1FQI8 20211085 PTHR12231:SF253 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG189438|UniProtKB=T1FR21 T1FR21 20211268 PTHR21219:SF3 FI19613P1 FI19613P1 HELRO|EnsemblGenome=HelroG186218|UniProtKB=T1FNT9 T1FNT9 20210486 PTHR43407:SF1 GLUTAMINE SYNTHETASE LENGSIN ligase activity#GO:0016874;catalytic activity#GO:0003824 proteinogenic amino acid biosynthetic process#GO:0170038;response to extracellular stimulus#GO:0009991;biosynthetic process#GO:0009058;cellular homeostasis#GO:0019725;carboxylic acid biosynthetic process#GO:0046394;nitrogen compound metabolic process#GO:0006807;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;L-amino acid metabolic process#GO:0170033;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;homeostatic process#GO:0042592;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;response to nutrient levels#GO:0031667;intracellular chemical homeostasis#GO:0055082;cellular process#GO:0009987;chemical homeostasis#GO:0048878;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;response to external stimulus#GO:0009605;response to stimulus#GO:0050896;alpha-amino acid biosynthetic process#GO:1901607;L-amino acid biosynthetic process#GO:0170034;small molecule biosynthetic process#GO:0044283;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 Glutamine glutamate conversion#P02745>Glutamine synthase#P04483;Glutamine glutamate conversion#P02745>Glutamine synthetase#P02968 HELRO|EnsemblGenome=HelroG177428|UniProtKB=T1FBP2 T1FBP2 20206241 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174638|UniProtKB=T1F8C0 T1F8C0 20205069 PTHR23282:SF146 APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR. RT07201P-RELATED HELRO|EnsemblGenome=HelroG98272|UniProtKB=T1G9L6 T1G9L6 20217762 PTHR15172:SF1 GALACTOCEREBROSIDASE GALACTOCEREBROSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;carbohydrate derivative catabolic process#GO:1901136;glycolipid metabolic process#GO:0006664;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;lipid catabolic process#GO:0016042;cellular process#GO:0009987;liposaccharide metabolic process#GO:1903509;sphingolipid metabolic process#GO:0006665;primary metabolic process#GO:0044238;ceramide metabolic process#GO:0006672;membrane lipid metabolic process#GO:0006643;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;sphingolipid catabolic process#GO:0030149;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248 cytoplasm#GO:0005737;lysosome#GO:0005764;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;lytic vacuole#GO:0000323;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 galactosidase#PC00104 HELRO|EnsemblGenome=HelroG103064|UniProtKB=T1EDE0 T1EDE0 20194592 PTHR11203:SF37 CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER INTEGRATOR COMPLEX SUBUNIT 11 catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG189164|UniProtKB=T1FQQ7 T1FQQ7 20211154 PTHR10258:SF8 CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA CALCIUM-ACTIVATED POTASSIUM CHANNEL BK ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;molecular function regulator activity#GO:0098772;transporter regulator activity#GO:0141108;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic ion-gated channel activity#GO:0022839;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium-activated cation channel activity#GO:0005227;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;potassium channel regulator activity#GO:0015459;ligand-gated monoatomic cation channel activity#GO:0099094;channel regulator activity#GO:0016247;monoatomic ion channel activity#GO:0005216;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 detection of stimulus#GO:0051606;response to stimulus#GO:0050896;response to chemical#GO:0042221;detection of chemical stimulus#GO:0009593 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG185654|UniProtKB=T1FN34 T1FN34 PTHR15735:SF12 FCH AND DOUBLE SH3 DOMAINS PROTEIN CDC42-INTERACTING PROTEIN 4, ISOFORM B cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG191852|UniProtKB=T1FTC8 T1FTC8 20212075 PTHR34929:SF1 ZGC:153157 INAF MOTIF CONTAINING 2 HELRO|EnsemblGenome=HelroG88988|UniProtKB=T1G779 T1G779 20216926 PTHR10068:SF14 BONE MARROW PROTEOGLYCAN CELL WALL ADHESIN EAP1 extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG73507|UniProtKB=T1G1F0 T1G1F0 20214898 PTHR11693:SF22 ATP SYNTHASE GAMMA CHAIN ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL monoatomic cation channel activity#GO:0005261;ligase activity#GO:0016874;inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;catalytic activity#GO:0003824;proton transmembrane transporter activity#GO:0015078;proton channel activity#GO:0015252;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;inorganic cation transmembrane transporter activity#GO:0022890;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 cellular aromatic compound metabolic process#GO:0006725;ribonucleoside triphosphate metabolic process#GO:0009199;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative metabolic process#GO:1901135;ATP biosynthetic process#GO:0006754;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;purine nucleoside triphosphate biosynthetic process#GO:0009145;heterocycle metabolic process#GO:0046483;purine ribonucleoside triphosphate metabolic process#GO:0009205;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;ribonucleoside triphosphate biosynthetic process#GO:0009201;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;proton motive force-driven ATP synthesis#GO:0015986;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;purine nucleoside triphosphate metabolic process#GO:0009144;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 ATP synthesis#P02721>F1 gamma#P02796 HELRO|EnsemblGenome=HelroG77670|UniProtKB=T1G319 T1G319 20215467 PTHR12788:SF10 PROTEIN-TYROSINE SULFOTRANSFERASE 2 PROTEIN-TYROSINE SULFOTRANSFERASE sulfotransferase activity#GO:0008146;transferase activity#GO:0016740;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity#GO:0003824 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG194721|UniProtKB=T1FWC5 T1FWC5 20213120 PTHR19229:SF250 ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;lipid transporter activity#GO:0005319;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;organic substance transport#GO:0071702;lipid localization#GO:0010876;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;lipid transport#GO:0006869;transport#GO:0006810 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG173509|UniProtKB=T1F6W9 T1F6W9 20204568 PTHR48209:SF2 AGL056WP FI24008P1 HELRO|EnsemblGenome=HelroG189155|UniProtKB=T1FQQ3 T1FQQ3 20211150 PTHR21704:SF18 NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED NIPPED-B-LIKE PROTEIN protein-containing complex binding#GO:0044877;binding#GO:0005488;chromatin binding#GO:0003682 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;cellular localization#GO:0051641;double-strand break repair#GO:0006302;macromolecule localization#GO:0033036;cell cycle process#GO:0022402;nucleobase-containing compound metabolic process#GO:0006139;mitotic cell cycle process#GO:1903047;establishment of protein localization#GO:0045184;sister chromatid cohesion#GO:0007062;DNA damage response#GO:0006974;mitotic cell cycle#GO:0000278;organic cyclic compound metabolic process#GO:1901360;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;recombinational repair#GO:0000725;protein localization to organelle#GO:0033365;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;mitotic sister chromatid cohesion#GO:0007064;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;double-strand break repair via homologous recombination#GO:0000724;DNA recombination#GO:0006310;protein localization#GO:0008104;primary metabolic process#GO:0044238;replication-born double-strand break repair via sister chromatid exchange#GO:1990414;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;cellular macromolecule localization#GO:0070727;response to stress#GO:0006950;organelle organization#GO:0006996;chromosome organization#GO:0051276;cell cycle#GO:0007049;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG111477|UniProtKB=T1EFB7 T1EFB7 20195269 PTHR24118:SF99 POTE ANKYRIN DOMAIN POTE ANKYRIN DOMAIN FAMILY MEMBER 3C-RELATED membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG181013|UniProtKB=T1FGJ0 T1FGJ0 20207939 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG164019|UniProtKB=T1EUS1 T1EUS1 20200321 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG80555|UniProtKB=T1G420 T1G420 20215818 PTHR31410:SF2 TRANSMEMBRANE PROTEIN 246 GLYCOSYL TRANSFERASE 64 DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757 HELRO|EnsemblGenome=HelroG95427|UniProtKB=T1G959 T1G959 20217606 PTHR45626:SF50 TRANSCRIPTION TERMINATION FACTOR 2-RELATED TRANSCRIPTION TERMINATION FACTOR 2 ATP-dependent activity, acting on DNA#GO:0008094;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on DNA#GO:0140097;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 Transcription regulation by bZIP transcription factor#P00055>TTF2#P01389 HELRO|EnsemblGenome=HelroG156757|UniProtKB=T1EM06 T1EM06 20197606 PTHR23055:SF178 CALCIUM BINDING PROTEINS NEUROCALCIN HOMOLOG cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG77283|UniProtKB=T1G2V6 T1G2V6 20215404 PTHR22980:SF0 CORTISTATIN CENTROMERE PROTEIN S protein-containing complex binding#GO:0044877;binding#GO:0005488;chromatin binding#GO:0003682 cellular aromatic compound metabolic process#GO:0006725;nuclear division#GO:0000280;cell cycle process#GO:0022402;nucleobase-containing compound metabolic process#GO:0006139;reciprocal homologous recombination#GO:0140527;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;meiotic cell cycle process#GO:1903046;DNA-templated DNA replication#GO:0006261;meiosis I cell cycle process#GO:0061982;reproductive process#GO:0022414;reciprocal meiotic recombination#GO:0007131;replication fork processing#GO:0031297;meiosis I#GO:0007127;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule metabolic process#GO:0043170;meiotic cell cycle#GO:0051321;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;DNA recombination#GO:0006310;resolution of meiotic recombination intermediates#GO:0000712;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;reproduction#GO:0000003;meiotic nuclear division#GO:0140013;organelle organization#GO:0006996;sexual reproduction#GO:0019953;cell cycle#GO:0007049;organelle fission#GO:0048285;homologous recombination#GO:0035825;DNA replication#GO:0006260;DNA metabolic process#GO:0006259 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 neuropeptide#PC00162;peptide hormone#PC00179 HELRO|EnsemblGenome=HelroG170910|UniProtKB=T1F3L1 T1F3L1 20203410 PTHR14596:SF76 ZINC FINGER PROTEIN DEFECTIVE CHORION PROTEIN, FC177 ISOFORM cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to nutrient levels#GO:0031667;response to extracellular stimulus#GO:0009991;response to stress#GO:0006950;response to starvation#GO:0042594 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG93032|UniProtKB=T1G8R4 T1G8R4 20217461 PTHR33269:SF17 NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6 NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG114508|UniProtKB=T1EG22 T1EG22 20195524 PTHR11461:SF372 SERINE PROTEASE INHIBITOR, SERPIN ACCESSORY GLAND PROTEIN ACP76A-RELATED extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG165194|UniProtKB=T1EWE9 T1EWE9 20200899 PTHR21538:SF23 ANILLIN/RHOTEKIN RTKN ANILLIN cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cell division#GO:0051301;actomyosin contractile ring assembly#GO:0000915;cell cycle process#GO:0022402;actomyosin structure organization#GO:0031032;cellular component organization#GO:0016043;cellular process#GO:0009987;cytokinetic process#GO:0032506;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;mitotic cytokinesis#GO:0000281;mitotic cell cycle#GO:0000278;actin filament-based process#GO:0030029;organelle organization#GO:0006996;cortical cytoskeleton organization#GO:0030865;cytoskeleton-dependent cytokinesis#GO:0061640;cell cycle#GO:0007049;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cytokinesis#GO:0000910;cortical actin cytoskeleton organization#GO:0030866;septin cytoskeleton organization#GO:0032185 actomyosin contractile ring#GO:0005826;cortical cytoskeleton#GO:0030863;cell cortex#GO:0005938;cell periphery#GO:0071944;cortical actin cytoskeleton#GO:0030864;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cell division site#GO:0032153;contractile ring#GO:0070938;cytoskeleton#GO:0005856 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG192162|UniProtKB=T1FTN1 T1FTN1 20212178 PTHR31901:SF9 GH3 DOMAIN-CONTAINING PROTEIN GH3 DOMAIN-CONTAINING PROTEIN ligase activity#GO:0016874;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG92327|UniProtKB=T1G8E5 T1G8E5 20217342 PTHR11143:SF7 60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER RIBOSOMAL PROTEIN L26 LIKE 1 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cytoplasmic translation#GO:0002181;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;cellular component organization or biogenesis#GO:0071840;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG192428|UniProtKB=T1FTY4 T1FTY4 20212281 PTHR24366:SF170 IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS RE50361P cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG189275|UniProtKB=T1FQW7 T1FQW7 20211214 PTHR13817:SF172 TITIN IG-LIKE DOMAIN-CONTAINING PROTEIN structural protein#PC00211 Axon guidance mediated by Slit/Robo#P00008>Robo#P00348 HELRO|EnsemblGenome=HelroG75335|UniProtKB=T1G238 T1G238 20215136 PTHR23048:SF33 MYOSIN LIGHT CHAIN 1, 3 MYOSIN LIGHT CHAIN ALKALI supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;supramolecular fiber#GO:0099512;supramolecular polymer#GO:0099081;myosin complex#GO:0016459;contractile fiber#GO:0043292;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG90986|UniProtKB=T1G7Y3 T1G7Y3 20217180 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG174160|UniProtKB=T1F7P7 T1F7P7 20204846 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189258|UniProtKB=T1FQV7 T1FQV7 20211204 PTHR24416:SF611 TYROSINE-PROTEIN KINASE RECEPTOR TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG158200|UniProtKB=T1EMK3 T1EMK3 20197803 PTHR43286:SF1 ENDONUCLEASE III-LIKE PROTEIN 1 ENDONUCLEASE III-LIKE PROTEIN 1 catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity, acting on DNA#GO:0140097;DNA N-glycosylase activity#GO:0019104;catalytic activity#GO:0003824 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;nucleotide-excision repair#GO:0006289;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;base-excision repair#GO:0006284;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 DNA metabolism protein#PC00009;DNA glycosylase#PC00010 HELRO|EnsemblGenome=HelroG143362|UniProtKB=T1EJA3 T1EJA3 20196653 PTHR12357:SF89 YTH YT521-B HOMOLOGY DOMAIN-CONTAINING YTH DOMAIN-CONTAINING FAMILY PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of mRNA stability#GO:0043488;regulation of catabolic process#GO:0009894;regulation of mRNA catabolic process#GO:0061013;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;positive regulation of cellular catabolic process#GO:0031331;RNA destabilization#GO:0050779;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;positive regulation of mRNA metabolic process#GO:1903313;regulation of RNA stability#GO:0043487;regulation of cellular catabolic process#GO:0031329;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;positive regulation of mRNA catabolic process#GO:0061014;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;positive regulation of catabolic process#GO:0009896;positive regulation of RNA metabolic process#GO:0051254;mRNA destabilization#GO:0061157;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;regulation of mRNA metabolic process#GO:1903311 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG78681|UniProtKB=T1G3E6 T1G3E6 20215594 PTHR23049:SF57 MYOSIN REGULATORY LIGHT CHAIN 2 MYOSIN REGULATORY LIGHT CHAIN 12A cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;myosin binding#GO:0017022;binding#GO:0005488 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;myosin complex#GO:0016459;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG164376|UniProtKB=T1EVC4 T1EVC4 20200524 PTHR10913:SF78 FOLLISTATIN-RELATED AGRIN multicellular organismal process#GO:0032501;cellular developmental process#GO:0048869;cell differentiation#GO:0030154;cellular process#GO:0009987;anatomical structure development#GO:0048856;multicellular organism development#GO:0007275;developmental process#GO:0032502 cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG189243|UniProtKB=T1FQV0 T1FQV0 20211197 PTHR45828:SF33 CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE DOMON DOMAIN-CONTAINING PROTEIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 reductase#PC00198;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG161177|UniProtKB=T1ER71 T1ER71 20199071 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG184808|UniProtKB=T1FM13 T1FM13 20209862 PTHR38926:SF72 F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED IM:7136021-RELATED HELRO|EnsemblGenome=HelroG170719|UniProtKB=T1F3C7 T1F3C7 20203326 PTHR18966:SF422 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED signaling receptor activity#GO:0038023;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;ligand-gated channel activity#GO:0022834 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019 HELRO|EnsemblGenome=HelroG194375|UniProtKB=T1FVZ9 T1FVZ9 20212995 PTHR25462:SF305 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG192676|UniProtKB=T1FU65 T1FU65 20212361 PTHR45775:SF6 RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C HELRO|EnsemblGenome=HelroG69078|UniProtKB=T1G6B1 T1G6B1 20216608 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77319|UniProtKB=T1G2W1 T1G2W1 20215409 PTHR11571:SF150 GLUTATHIONE S-TRANSFERASE GLUTATHIONE S-TRANSFERASE glutathione transferase activity#GO:0004364;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824 sulfur compound metabolic process#GO:0006790;nitrogen compound metabolic process#GO:0006807;peptide metabolic process#GO:0006518;cellular modified amino acid metabolic process#GO:0006575;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular process#GO:0009987;glutathione metabolic process#GO:0006749;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG193204|UniProtKB=T1FUR1 T1FUR1 20212557 PTHR13328:SF4 NEGATIVE ELONGATION FACTOR A NELF-A NEGATIVE ELONGATION FACTOR A HELRO|EnsemblGenome=HelroG175314|UniProtKB=T1F949 T1F949 20205348 PTHR23003:SF3 RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN FI21236P1-RELATED nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG81227|UniProtKB=T1G4B7 T1G4B7 20215915 PTHR13966:SF19 ENDONUCLEASE RELATED NUCLEASE EXOG, MITOCHONDRIAL catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;DNA endonuclease activity#GO:0004520;nuclease activity#GO:0004518;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;execution phase of apoptosis#GO:0097194;heterocycle catabolic process#GO:0046700;macromolecule metabolic process#GO:0043170;DNA catabolic process#GO:0006308;cellular metabolic process#GO:0044237;programmed cell death#GO:0012501;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular nitrogen compound catabolic process#GO:0044270;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;cellular component disassembly#GO:0022411;aromatic compound catabolic process#GO:0019439;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;apoptotic process#GO:0006915;cell death#GO:0008219;organic cyclic compound catabolic process#GO:1901361;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;nucleobase-containing compound catabolic process#GO:0034655;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;cellular catabolic process#GO:0044248 envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;organelle inner membrane#GO:0019866;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG80663|UniProtKB=T1G436 T1G436 20215834 PTHR28580:SF1 GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5 GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;RNA metabolic process#GO:0016070;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;nucleotide-excision repair#GO:0006289;cellular component assembly#GO:0022607;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;aromatic compound biosynthetic process#GO:0019438;cellular response to stress#GO:0033554;transcription by RNA polymerase II#GO:0006366;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;DNA-directed RNA polymerase complex#GO:0000428;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nucleoplasm#GO:0005654;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;serine/threonine protein kinase complex#GO:1902554;RNA polymerase II transcription regulator complex#GO:0090575;protein kinase complex#GO:1902911;transcription factor TFIIH core complex#GO:0000439;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;transcription regulator complex#GO:0005667;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;transcription factor TFIIH holo complex#GO:0005675;nuclear protein-containing complex#GO:0140513 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG185454|UniProtKB=T1FMU4 T1FMU4 20210143 PTHR10138:SF0 TRYPTOPHAN 2,3-DIOXYGENASE TRYPTOPHAN 2,3-DIOXYGENASE oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;dioxygenase activity#GO:0051213;tetrapyrrole binding#GO:0046906;oxidoreductase activity#GO:0016491;heme binding#GO:0020037 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;sulfur compound metabolic process#GO:0006790;heterocycle catabolic process#GO:0046700;biogenic amine metabolic process#GO:0006576;organonitrogen compound catabolic process#GO:1901565;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;cellular nitrogen compound catabolic process#GO:0044270;amino acid catabolic process#GO:0009063;organic cyclic compound metabolic process#GO:1901360;aromatic amino acid metabolic process#GO:0009072;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;alpha-amino acid metabolic process#GO:1901605;purine-containing compound metabolic process#GO:0072521;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;amide metabolic process#GO:0043603;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;oxoacid metabolic process#GO:0043436;heterocycle metabolic process#GO:0046483;amine metabolic process#GO:0009308;acyl-CoA metabolic process#GO:0006637;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;aromatic compound catabolic process#GO:0019439;small molecule catabolic process#GO:0044282;organic cyclic compound catabolic process#GO:1901361;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;carboxylic acid metabolic process#GO:0019752;aromatic amino acid family catabolic process#GO:0009074;amino acid metabolic process#GO:0006520;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG183799|UniProtKB=T1FK76 T1FK76 20209225 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG66106|UniProtKB=T1FYH0 T1FYH0 20213868 PTHR13681:SF26 SURVIVAL OF MOTOR NEURON-RELATED-SPLICING FACTOR 30-RELATED SURVIVAL OF MOTOR NEURON-RELATED-SPLICING FACTOR 30 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG185666|UniProtKB=T1FN42 T1FN42 20210240 PTHR20883:SF15 PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1 PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1 oxygenase#PC00177;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG162604|UniProtKB=T1ESX1 T1ESX1 20199671 PTHR11042:SF136 EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED EIF-2-ALPHA KINASE GCN2 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191511|UniProtKB=T1FT20 T1FT20 20211967 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED FMRFAMIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG192978|UniProtKB=T1FUH2 T1FUH2 20212468 PTHR15710:SF243 E3 UBIQUITIN-PROTEIN LIGASE PRAJA E3 UBIQUITIN-PROTEIN LIGASE PRAJA-2 ISOFORM X1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG69796|UniProtKB=T1FZY6 T1FZY6 20214384 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG175883|UniProtKB=T1F9T9 T1F9T9 20205588 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167889|UniProtKB=T1EZX4 T1EZX4 20202124 PTHR14735:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 134 COILED-COIL DOMAIN-CONTAINING PROTEIN 134 HELRO|EnsemblGenome=HelroG165468|UniProtKB=T1EWU9 T1EWU9 20201049 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG73695|UniProtKB=T1G1H3 T1G1H3 20214921 PTHR24406:SF26 TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED C2H2-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;protein-containing complex binding#GO:0044877;chromatin DNA binding#GO:0031490;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG176482|UniProtKB=T1FAK3 T1FAK3 20205852 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG89788|UniProtKB=T1G7H7 T1G7H7 20217024 PTHR45676:SF41 RING-H2 FINGER PROTEIN ATL51-RELATED RING-H2 FINGER PROTEIN ATL66 HELRO|EnsemblGenome=HelroG163587|UniProtKB=T1EU92 T1EU92 20200142 PTHR43404:SF1 LIPOPOLYSACCHARIDE CHOLINEPHOSPHOTRANSFERASE LICD MNN4P transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG177554|UniProtKB=T1FBV6 T1FBV6 20206305 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG156641|UniProtKB=T1ELZ1 T1ELZ1 20197591 PTHR12941:SF10 ER MEMBRANE PROTEIN COMPLEX ER MEMBRANE PROTEIN COMPLEX SUBUNIT 8_9 HOMOLOG membrane protein complex#GO:0098796;endoplasmic reticulum protein-containing complex#GO:0140534;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;EMC complex#GO:0072546;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG62904|UniProtKB=T1FX71 T1FX71 20213419 PTHR12309:SF5 SEC61 GAMMA SUBUNIT PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT GAMMA protein transmembrane transporter activity#GO:0008320;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization within membrane#GO:0051668;cellular localization#GO:0051641;intracellular protein transmembrane transport#GO:0065002;protein localization to endoplasmic reticulum#GO:0070972;transmembrane transport#GO:0055085;macromolecule localization#GO:0033036;post-translational protein targeting to membrane, translocation#GO:0031204;protein localization to membrane#GO:0072657;transport#GO:0006810;protein transmembrane transport#GO:0071806;protein targeting#GO:0006605;nitrogen compound transport#GO:0071705;protein targeting to ER#GO:0045047;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;establishment of protein localization to membrane#GO:0090150;post-translational protein targeting to endoplasmic reticulum membrane#GO:0006620;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365;establishment of protein localization to endoplasmic reticulum#GO:0072599 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;endoplasmic reticulum protein-containing complex#GO:0140534;rough endoplasmic reticulum membrane#GO:0030867;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;rough endoplasmic reticulum#GO:0005791;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG176701|UniProtKB=T1FAT0 T1FAT0 20205929 PTHR47827:SF3 AHD DOMAIN-CONTAINING PROTEIN AF-9 ANC1 HOMOLOGY DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;protein-containing complex binding#GO:0044877;histone binding#GO:0042393;binding#GO:0005488;chromatin binding#GO:0003682;modification-dependent protein binding#GO:0140030 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;transcription elongation factor complex#GO:0008023;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185333|UniProtKB=T1FMP3 T1FMP3 20210092 PTHR11071:SF561 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;catalytic activity#GO:0003824;peptide binding#GO:0042277;amide binding#GO:0033218 macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein peptidyl-prolyl isomerization#GO:0000413;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG97167|UniProtKB=T1G9F7 T1G9F7 20217704 PTHR24056:SF107 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 11A-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;regulation of mitotic cell cycle#GO:0007346;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG68175|UniProtKB=T1FZB4 T1FZB4 20214162 PTHR24056:SF46 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 5 cyclin-dependent protein kinase activity#GO:0097472;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Nicotine pharmacodynamics pathway#P06587>CDK5#P06597;Axon guidance mediated by semaphorins#P00007>Cdk5#P00336;p53 pathway#P00059>Cdc2#P04634;Dopamine receptor mediated signaling pathway#P05912>CDK5#P05951 HELRO|EnsemblGenome=HelroG163408|UniProtKB=T1EU04 T1EU04 20200054 PTHR31684:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 43 COILED-COIL DOMAIN-CONTAINING PROTEIN 43 HELRO|EnsemblGenome=HelroG95007|UniProtKB=T1G941 T1G941 20217588 PTHR19139:SF199 AQUAPORIN TRANSPORTER MIP17260P cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG176770|UniProtKB=T1FAW4 T1FAW4 20205963 PTHR18945:SF925 NEUROTRANSMITTER GATED ION CHANNEL DUF4706 DOMAIN-CONTAINING PROTEIN ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG134860|UniProtKB=T1EI61 T1EI61 20196261 PTHR13605:SF4 ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7 ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7 membrane protein complex#GO:0098796;endoplasmic reticulum protein-containing complex#GO:0140534;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;EMC complex#GO:0072546;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG162678|UniProtKB=T1ET04 T1ET04 20199704 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG86393|UniProtKB=T1G6B6 T1G6B6 20216613 PTHR11210:SF2 RING BOX E3 UBIQUITIN-PROTEIN LIGASE RBX1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;cullin family protein binding#GO:0097602;protein binding#GO:0005515;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG184581|UniProtKB=T1FLI8 T1FLI8 20209687 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185957|UniProtKB=T1FNH5 T1FNH5 20210372 PTHR20920:SF5 RPE-SPONDIN SMB DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162488|UniProtKB=T1ESQ7 T1ESQ7 20199607 PTHR23121:SF9 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 transmembrane transporter activity#GO:0022857;sugar transmembrane transporter activity#GO:0051119;transporter activity#GO:0005215;carbohydrate transmembrane transporter activity#GO:0015144 transporter#PC00227 HELRO|EnsemblGenome=HelroG161720|UniProtKB=T1ERU0 T1ERU0 20199290 PTHR16021:SF23 MANSC DOMAIN CONTAINING PROTEIN 1 FI18411P1-RELATED HELRO|EnsemblGenome=HelroG66963|UniProtKB=T1FYT9 T1FYT9 20213987 PTHR23055:SF167 CALCIUM BINDING PROTEINS EF-HAND DOMAIN-CONTAINING PROTEIN cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG163373|UniProtKB=T1ETZ0 T1ETZ0 20200040 PTHR33604:SF3 OSJNBA0004B13.7 PROTEIN OSJNBA0004B13.7 PROTEIN HELRO|EnsemblGenome=HelroG158112|UniProtKB=T1EMJ5 T1EMJ5 20197795 PTHR11879:SF55 ASPARTATE AMINOTRANSFERASE GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B transaminase activity#GO:0008483;transferase activity#GO:0016740;catalytic activity#GO:0003824 transaminase#PC00216;transferase#PC00220;metabolite interconversion enzyme#PC00262 Asparagine and aspartate biosynthesis#P02730>Aspartate aminotransferase#P02854 HELRO|EnsemblGenome=HelroG92749|UniProtKB=T1G8K4 T1G8K4 20217401 PTHR13832:SF803 PROTEIN PHOSPHATASE 2C PROTEIN PHOSPHATASE 1G macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;dephosphorylation#GO:0016311;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG188262|UniProtKB=T1FPT4 T1FPT4 20210831 PTHR22588:SF3 VWFA DOMAIN-CONTAINING PROTEIN VWFA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177354|UniProtKB=T1FBK0 T1FBK0 20206199 PTHR22801:SF63 LITHOSTATHINE C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG71540|UniProtKB=T1G0N0 T1G0N0 20214628 PTHR46176:SF1 LD21662P LD21662P HELRO|EnsemblGenome=HelroG182385|UniProtKB=T1FI44 T1FI44 20208493 PTHR22600:SF57 BETA-HEXOSAMINIDASE BETA-N-ACETYLHEXOSAMINIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 glycosaminoglycan metabolic process#GO:0030203;carbohydrate derivative metabolic process#GO:1901135;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;aminoglycan metabolic process#GO:0006022;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;membrane#GO:0016020 glycosidase#PC00110;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG82945|UniProtKB=T1G4Y3 T1G4Y3 20216131 PTHR47977:SF26 RAS-RELATED PROTEIN RAB RAB1B, MEMBER RAS ONCO FAMILY GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;transport#GO:0006810 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG178409|UniProtKB=T1FD47 T1FD47 20206746 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG170266|UniProtKB=T1F2U9 T1F2U9 20203148 PTHR10590:SF4 SODIUM/NUCLEOSIDE COTRANSPORTER SOLUTE CARRIER FAMILY 28 MEMBER 3 carbohydrate derivative transmembrane transporter activity#GO:1901505;secondary active transmembrane transporter activity#GO:0015291;nucleoside transmembrane transporter activity#GO:0005337;transmembrane transporter activity#GO:0022857;symporter activity#GO:0015293;nucleobase-containing compound transmembrane transporter activity#GO:0015932;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215 localization#GO:0051179;organic substance transport#GO:0071702;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;nucleobase-containing compound transport#GO:0015931;transport#GO:0006810;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG81691|UniProtKB=T1G4H6 T1G4H6 20215974 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG126349|UniProtKB=T1EH96 T1EH96 20195946 PTHR23235:SF177 KRUEPPEL-LIKE TRANSCRIPTION FACTOR C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG164840|UniProtKB=T1EVV4 T1EVV4 20200704 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG102762|UniProtKB=T1EDB5 T1EDB5 20194567 PTHR11003:SF334 POTASSIUM CHANNEL, SUBFAMILY K FI03418P monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG145549|UniProtKB=T1EJL0 T1EJL0 20196760 PTHR13439:SF4 CT120 PROTEIN TLC DOMAIN-CONTAINING PROTEIN cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;membrane assembly#GO:0071709;regulation of biological quality#GO:0065008;membrane organization#GO:0061024;plasma membrane organization#GO:0007009;biological regulation#GO:0065007;lipid homeostasis#GO:0055088;endomembrane system organization#GO:0010256;homeostatic process#GO:0042592;cellular component organization#GO:0016043;regulation of membrane lipid distribution#GO:0097035;chemical homeostasis#GO:0048878;cellular process#GO:0009987 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG82198|UniProtKB=T1G4P1 T1G4P1 20216039 PTHR10913:SF45 FOLLISTATIN-RELATED FOLLISTATIN, ISOFORM A-RELATED cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG107931|UniProtKB=T1EEE1 T1EEE1 20194943 PTHR12442:SF22 DYNEIN INTERMEDIATE CHAIN CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED protein binding#GO:0005515;binding#GO:0005488 localization#GO:0051179;cellular localization#GO:0051641;microtubule-based transport#GO:0099111;establishment of localization#GO:0051234;microtubule-based process#GO:0007017;transport#GO:0006810;cytoskeleton-dependent intracellular transport#GO:0030705;microtubule-based movement#GO:0007018;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular process#GO:0009987;transport along microtubule#GO:0010970 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;microtubule cytoskeleton#GO:0015630;dynein complex#GO:0030286;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic dynein complex#GO:0005868;intracellular anatomical structure#GO:0005622 microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Dynein complex#P00774 HELRO|EnsemblGenome=HelroG185626|UniProtKB=T1FN22 T1FN22 20210221 PTHR11937:SF155 ACTIN ACTIN-RELATED PROTEIN 1 actin and actin related protein#PC00039;cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Nicotinic acetylcholine receptor signaling pathway#P00044>Actin#P01090 HELRO|EnsemblGenome=HelroG165982|UniProtKB=T1EXJ2 T1EXJ2 20201292 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173142|UniProtKB=T1F6G1 T1F6G1 20204410 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194255|UniProtKB=T1FVV5 T1FVV5 20212951 PTHR10634:SF67 AN1-TYPE ZINC FINGER PROTEIN AN1-TYPE ZINC FINGER PROTEIN 3 HELRO|EnsemblGenome=HelroG161733|UniProtKB=T1ERU7 T1ERU7 20199297 PTHR47537:SF2 CUBILIN CUBILIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG164927|UniProtKB=T1EVZ3 T1EVZ3 20200743 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG76730|UniProtKB=T1G2N6 T1G2N6 20215334 PTHR24291:SF201 CYTOCHROME P450 FAMILY 4 CYTOCHROME P450, FAMILY 4, SUBFAMILY B, POLYPEPTIDE 7 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG185489|UniProtKB=T1FMV9 T1FMV9 20210158 PTHR48419:SF1 SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG66475|UniProtKB=T1FYL6 T1FYL6 20213914 PTHR23257:SF947 SERINE-THREONINE PROTEIN KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG172522|UniProtKB=T1F5G4 T1F5G4 20204063 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194061|UniProtKB=T1FVM8 T1FVM8 20212874 PTHR24203:SF83 ANKYRIN REPEAT FAMILY PROTEIN EIF3K HELRO|EnsemblGenome=HelroG170428|UniProtKB=T1F317 T1F317 20203216 PTHR47032:SF1 UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG68624|UniProtKB=T1FZH4 T1FZH4 20214222 PTHR22890:SF2 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mediator complex#GO:0016592;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG177013|UniProtKB=T1FB52 T1FB52 20206051 PTHR45615:SF40 MYOSIN HEAVY CHAIN, NON-MUSCLE MYOSIN HEAVY CHAIN, NON-MUSCLE microfilament motor activity#GO:0000146;cytoskeletal protein binding#GO:0008092;ATP-dependent activity#GO:0140657;binding#GO:0005488;actin filament binding#GO:0051015;cytoskeletal motor activity#GO:0003774;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779 supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;supramolecular fiber#GO:0099512;supramolecular polymer#GO:0099081;myosin complex#GO:0016459;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Myosin#P00867;Cytoskeletal regulation by Rho GTPase#P00016>Myosin#P00522;Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG95512|UniProtKB=T1G964 T1G964 20217611 PTHR11909:SF7 CASEIN KINASE-RELATED CELL DIVISION CYCLE 7-RELATED PROTEIN KINASE transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;signal transduction#GO:0007165;double-strand break repair#GO:0006302;macromolecule modification#GO:0043412;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;peptidyl-serine phosphorylation#GO:0018105;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;recombinational repair#GO:0000725;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;double-strand break repair via homologous recombination#GO:0000724;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;double-strand break repair via break-induced replication#GO:0000727;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG185033|UniProtKB=T1FMB3 T1FMB3 20209962 PTHR11893:SF36 INNEXIN INNEXIN-5 cell junction protein#PC00070;gap junction#PC00105 HELRO|EnsemblGenome=HelroG114071|UniProtKB=T1EFY7 T1EFY7 20195489 PTHR21650:SF4 MEMBRALIN/KINETOCHORE PROTEIN NUF2 MEMBRALIN positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of protein metabolic process#GO:0051246;regulation of catabolic process#GO:0009894;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of proteasomal protein catabolic process#GO:1901800;regulation of protein catabolic process#GO:0042176;regulation of proteolysis involved in protein catabolic process#GO:1903050;positive regulation of proteolysis#GO:0045862;regulation of biological process#GO:0050789;positive regulation of response to stimulus#GO:0048584;regulation of cellular response to stress#GO:0080135;positive regulation of metabolic process#GO:0009893;positive regulation of biological process#GO:0048518;regulation of proteolysis#GO:0030162;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;positive regulation of proteolysis involved in protein catabolic process#GO:1903052;regulation of response to endoplasmic reticulum stress#GO:1905897;regulation of response to stress#GO:0080134;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of proteasomal protein catabolic process#GO:0061136;regulation of response to stimulus#GO:0048583;response to stimulus#GO:0050896;positive regulation of protein metabolic process#GO:0051247;response to stress#GO:0006950;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;positive regulation of catabolic process#GO:0009896;cellular response to stress#GO:0033554;positive regulation of protein catabolic process#GO:0045732;regulation of metabolic process#GO:0019222 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG108136|UniProtKB=T1EEF7 T1EEF7 20194959 PTHR43069:SF2 FUMARYLACETOACETASE FUMARYLACETOACETASE hydrolase activity#GO:0016787;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tyrosine metabolic process#GO:0006570;organonitrogen compound catabolic process#GO:1901565;amino acid catabolic process#GO:0009063;organic cyclic compound metabolic process#GO:1901360;aromatic amino acid metabolic process#GO:0009072;nitrogen compound metabolic process#GO:0006807;alpha-amino acid metabolic process#GO:1901605;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;L-amino acid metabolic process#GO:0170033;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;organic hydroxy compound metabolic process#GO:1901615;proteinogenic amino acid metabolic process#GO:0170039;oxoacid metabolic process#GO:0043436;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;aromatic compound catabolic process#GO:0019439;organic cyclic compound catabolic process#GO:1901361;aromatic amino acid family catabolic process#GO:0009074;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329 HELRO|EnsemblGenome=HelroG104718|UniProtKB=T1EDN3 T1EDN3 20194685 PTHR12709:SF4 DNA-DIRECTED RNA POLYMERASE II, III DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG156918|UniProtKB=T1EM32 T1EM32 20197632 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED single-stranded RNA binding#GO:0003727;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;poly(A) binding#GO:0008143;binding#GO:0005488;organic cyclic compound binding#GO:0097159 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG186214|UniProtKB=T1FNT8 T1FNT8 20210485 PTHR14154:SF3 UPF0041 BRAIN PROTEIN 44-RELATED MITOCHONDRIAL PYRUVATE CARRIER transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;monocarboxylic acid transmembrane transporter activity#GO:0008028;organic anion transmembrane transporter activity#GO:0008514;organic acid transmembrane transporter activity#GO:0005342;transporter activity#GO:0005215 localization#GO:0051179;mitochondrial transport#GO:0006839;organic substance transport#GO:0071702;monocarboxylic acid transport#GO:0015718;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;organic acid transmembrane transport#GO:1903825;cellular process#GO:0009987;mitochondrial transmembrane transport#GO:1990542;carboxylic acid transmembrane transport#GO:1905039 envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;organelle inner membrane#GO:0019866;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG92300|UniProtKB=T1G8E0 T1G8E0 20217337 PTHR15302:SF0 E3 UBIQUITIN-PROTEIN LIGASE RNF103 E3 UBIQUITIN-PROTEIN LIGASE RNF103 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;protein catabolic process#GO:0030163;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;protein ubiquitination#GO:0016567;macromolecule catabolic process#GO:0009057;response to endoplasmic reticulum stress#GO:0034976;protein modification by small protein conjugation or removal#GO:0070647;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;ERAD pathway#GO:0036503;response to organonitrogen compound#GO:0010243;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;cellular response to stress#GO:0033554 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG167031|UniProtKB=T1EYX4 T1EYX4 20201774 PTHR45598:SF2 PROTEIN CBG11839-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG79067|UniProtKB=T1G3J8 T1G3J8 20215646 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG177251|UniProtKB=T1FBE8 T1FBE8 20206147 PTHR11046:SF25 OLIGORIBONUCLEASE, MITOCHONDRIAL SUBFAMILY NOT NAMED endoribonuclease#PC00094;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG179171|UniProtKB=T1FEA7 T1FEA7 20207156 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171558|UniProtKB=T1F4E7 T1F4E7 20203696 PTHR47977:SF92 RAS-RELATED PROTEIN RAB EF-HAND DOMAIN-CONTAINING PROTEIN GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;transport#GO:0006810 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG94672|UniProtKB=T1G922 T1G922 20217569 PTHR45629:SF7 SNF2/RAD54 FAMILY MEMBER DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED damaged DNA-binding protein#PC00086;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG159175|UniProtKB=T1ENP6 T1ENP6 20198196 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173407|UniProtKB=T1F6S3 T1F6S3 20204522 PTHR38537:SF16 JITTERBUG, ISOFORM N CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180596|UniProtKB=T1FG29 T1FG29 20207778 PTHR12280:SF20 PANTOTHENATE KINASE 4'-PHOSPHOPANTETHEINE PHOSPHATASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 kinase#PC00137 Coenzyme A biosynthesis#P02736>Pantothenate kinase#P02885 HELRO|EnsemblGenome=HelroG170437|UniProtKB=T1F324 T1F324 20203223 PTHR22526:SF2 ANAPHASE PROMOTING COMPLEX C SUBUNIT 15, PSEUDOGENE-RELATED ANAPHASE PROMOTING COMPLEX C SUBUNIT 15, PSEUDOGENE-RELATED regulation of chromosome organization#GO:0033044;regulation of cell communication#GO:0010646;regulation of mitotic nuclear division#GO:0007088;regulation of mitotic sister chromatid separation#GO:0010965;regulation of chromosome segregation#GO:0051983;regulation of nuclear division#GO:0051783;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of organelle organization#GO:0033043;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;regulation of chromosome separation#GO:1905818;regulation of signaling#GO:0023051;regulation of cell cycle phase transition#GO:1901987;regulation of cellular component organization#GO:0051128;regulation of intracellular signal transduction#GO:1902531;regulation of mitotic metaphase/anaphase transition#GO:0030071;regulation of cell cycle process#GO:0010564;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of mitotic sister chromatid segregation#GO:0033047;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;regulation of sister chromatid segregation#GO:0033045;regulation of mitotic cell cycle#GO:0007346 ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234;anaphase-promoting complex#GO:0005680;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG87515|UniProtKB=T1G6R4 T1G6R4 20216761 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED single-stranded RNA binding#GO:0003727;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;poly(A) binding#GO:0008143;binding#GO:0005488;organic cyclic compound binding#GO:0097159 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG188224|UniProtKB=T1FPS5 T1FPS5 20210822 PTHR23320:SF165 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MARVEL DOMAIN-CONTAINING PROTEIN transporter#PC00227 HELRO|EnsemblGenome=HelroG98250|UniProtKB=T1G9L3 T1G9L3 20217759 PTHR14212:SF0 U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;spliceosomal tri-snRNP complex#GO:0097526;U4/U6 x U5 tri-snRNP complex#GO:0046540;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 mRNA splicing#P00058>U4#P01476;mRNA splicing#P00058>U6#P01473 HELRO|EnsemblGenome=HelroG171830|UniProtKB=T1F4R3 T1F4R3 20203812 PTHR12522:SF4 ZINC-FINGER PROTEIN NOLZ1-RELATED ZINC FINGER PROTEIN ELBOW negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG157396|UniProtKB=T1EMA9 T1EMA9 20197709 PTHR45794:SF1 LEUCYL-TRNA SYNTHETASE LEUCINE--TRNA LIGASE, CYTOPLASMIC catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG165370|UniProtKB=T1EWN5 T1EWN5 20200985 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN SI:DKEY-17M8.2 HELRO|EnsemblGenome=HelroG157283|UniProtKB=T1EM88 T1EM88 20197688 PTHR11593:SF10 60S RIBOSOMAL PROTEIN L17 60S RIBOSOMAL PROTEIN L17 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cytoplasmic translation#GO:0002181;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG144985|UniProtKB=T1EJH8 T1EJH8 20196728 PTHR11467:SF36 HISTONE H1 HISTONE 24-RELATED nucleosome binding#GO:0031491;nucleic acid binding#GO:0003676;chromatin DNA binding#GO:0031490;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;protein-containing complex binding#GO:0044877 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA metabolic process#GO:0051052;chromosome condensation#GO:0030261;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;cellular process#GO:0009987;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;regulation of macromolecule metabolic process#GO:0060255;organelle organization#GO:0006996;chromosome organization#GO:0051276;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA recombination#GO:0045910;negative regulation of DNA metabolic process#GO:0051053;regulation of DNA recombination#GO:0000018;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG110207|UniProtKB=T1EF05 T1EF05 20195157 PTHR23406:SF90 MALIC ENZYME-RELATED MALIC ENZYME-RELATED oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 oxoacid metabolic process#GO:0043436;dicarboxylic acid metabolic process#GO:0043648;cellular metabolic process#GO:0044237;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG186951|UniProtKB=T1FP47 T1FP47 20210594 PTHR12114:SF4 PARVIN GH23568P cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;actin binding#GO:0003779;binding#GO:0005488 cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;organelle organization#GO:0006996 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 actin and actin related protein#PC00039;cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG185682|UniProtKB=T1FN51 T1FN51 20210249 PTHR24012:SF491 RNA BINDING PROTEIN LD36772P-RELATED nucleic acid binding#GO:0003676;single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159;mRNA binding#GO:0003729;poly(A) binding#GO:0008143;mRNA 3'-UTR binding#GO:0003730 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG174243|UniProtKB=T1F7V4 T1F7V4 20204903 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170154|UniProtKB=T1F2Q2 T1F2Q2 20203101 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG188313|UniProtKB=T1FPV2 T1FPV2 20210849 PTHR10574:SF444 NETRIN/LAMININ-RELATED BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN animal organ morphogenesis#GO:0009887;anatomical structure morphogenesis#GO:0009653;tissue development#GO:0009888;anatomical structure development#GO:0048856;animal organ development#GO:0048513;developmental process#GO:0032502 extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Laminin#P00947 HELRO|EnsemblGenome=HelroG86450|UniProtKB=T1G6C4 T1G6C4 20216621 PTHR12231:SF253 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG192044|UniProtKB=T1FTJ4 T1FTJ4 20212141 PTHR46636:SF1 CDK2-ASSOCIATED AND CULLIN DOMAIN-CONTAINING PROTEIN 1 CDK2-ASSOCIATED AND CULLIN DOMAIN-CONTAINING PROTEIN 1 enzyme binding#GO:0019899;protein binding#GO:0005515;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;mitotic cell cycle phase transition#GO:0044772;regulation of nitrogen compound metabolic process#GO:0051171;cell cycle G1/S phase transition#GO:0044843;positive regulation of cellular metabolic process#GO:0031325;cell cycle process#GO:0022402;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;positive regulation of protein modification process#GO:0031401;mitotic cell cycle process#GO:1903047;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;G1/S transition of mitotic cell cycle#GO:0000082;mitotic cell cycle#GO:0000278;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;regulation of kinase activity#GO:0043549;regulation of protein kinase activity#GO:0045859;positive regulation of protein phosphorylation#GO:0001934;positive regulation of phosphorylation#GO:0042327;positive regulation of catalytic activity#GO:0043085;positive regulation of phosphorus metabolic process#GO:0010562;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;cell cycle phase transition#GO:0044770;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;positive regulation of protein metabolic process#GO:0051247;positive regulation of phosphate metabolic process#GO:0045937;regulation of macromolecule metabolic process#GO:0060255;positive regulation of protein kinase activity#GO:0045860;regulation of cellular process#GO:0050794;regulation of protein phosphorylation#GO:0001932;biological regulation#GO:0065007;cell cycle#GO:0007049;positive regulation of kinase activity#GO:0033674;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 HELRO|EnsemblGenome=HelroG183219|UniProtKB=T1FJC0 T1FJC0 20208919 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG172356|UniProtKB=T1F579 T1F579 20203978 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG167462|UniProtKB=T1EZE5 T1EZE5 20201945 PTHR11913:SF12 COFILIN-RELATED COFILIN_ACTIN-DEPOLYMERIZING FACTOR HOMOLOG-RELATED cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;cellular component disassembly#GO:0022411;actin filament-based process#GO:0030029;protein-containing complex disassembly#GO:0032984;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;actin polymerization or depolymerization#GO:0008154;cellular component organization#GO:0016043;protein depolymerization#GO:0051261;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;actin filament depolymerization#GO:0030042 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 Cytoskeletal regulation by Rho GTPase#P00016>Cofilin#P00508 HELRO|EnsemblGenome=HelroG181042|UniProtKB=T1FGK0 T1FGK0 20207949 PTHR33137:SF48 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15A-RELATED E3 UBIQUITIN-PROTEIN LIGASE IRF2BPL-RELATED general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG75178|UniProtKB=T1G222 T1G222 20215120 PTHR19850:SF25 GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1 molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591;signaling receptor complex adaptor activity#GO:0030159;protein-macromolecule adaptor activity#GO:0030674 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;plasma membrane protein complex#GO:0098797;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;side of membrane#GO:0098552;cytoplasmic side of plasma membrane#GO:0009898;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;extrinsic component of membrane#GO:0019898 heterotrimeric G-protein#PC00117;G-protein#PC00020 5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;5HT4 type receptor mediated signaling pathway#P04376>G-protein#P04430;Histamine H2 receptor mediated signaling pathway#P04386>G-Protein#P04490;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;Beta1 adrenergic receptor signaling pathway#P04377>G-Protein#P04436;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Gbeta#P00710;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Opioid prodynorphin pathway#P05916>G-protein#P06002;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;Wnt signaling pathway#P00057>GBeta#P01457;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Enkephalin release#P05913>G-Protein (i)#P05974;PI3 kinase pathway#P00048>Gbetagamma#P01188;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Gbeta#P00727;Enkephalin release#P05913>G-Protein (s)#P05977;Opioid proenkephalin pathway#P05915>G-protein#P05994;Beta3 adrenergic receptor signaling pathway#P04379>G-Protein#P04448;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Beta2 adrenergic receptor signaling pathway#P04378>G-Protein#P04443;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Gbeta#P00753 HELRO|EnsemblGenome=HelroG150486|UniProtKB=T1EKF8 T1EKF8 20197058 PTHR24055:SF561 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE 7 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 CCKR signaling map#P06959>MAPK7#P07021;EGF receptor signaling pathway#P00018>ERK1-2#P00543;Interleukin signaling pathway#P00036>ERK#P00965;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>MAPK#P00835;PDGF signaling pathway#P00047>ERK#P01143;FGF signaling pathway#P00021>ERK1-2#P00627;Interferon-gamma signaling pathway#P00035>Serine kinase#P00955;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;Apoptosis signaling pathway#P00006>MAPK#P00269;TGF-beta signaling pathway#P00052>p42/p44MAPKs#P01293;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>ERK#P00889;Parkinson disease#P00049>ERK#P01211;Endothelin signaling pathway#P00019>ERK#P00566 HELRO|EnsemblGenome=HelroG162659|UniProtKB=T1ESZ3 T1ESZ3 20199693 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173745|UniProtKB=T1F768 T1F768 20204667 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG185477|UniProtKB=T1FMV4 T1FMV4 20210153 PTHR10502:SF102 ANNEXIN ANNEXIN B11 lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488;phosphatidylserine binding#GO:0001786 cytoplasm#GO:0005737;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG190724|UniProtKB=T1FS87 T1FS87 20211684 PTHR46170:SF1 GATOR COMPLEX PROTEIN WDR59 GATOR COMPLEX PROTEIN WDR59 molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591;protein-macromolecule adaptor activity#GO:0030674 positive regulation of signal transduction#GO:0009967;regulation of signaling#GO:0023051;response to extracellular stimulus#GO:0009991;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;positive regulation of response to stimulus#GO:0048584;cellular response to starvation#GO:0009267;positive regulation of TOR signaling#GO:0032008;regulation of signal transduction#GO:0009966;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;cellular response to extracellular stimulus#GO:0031668;regulation of cell communication#GO:0010646;positive regulation of TORC1 signaling#GO:1904263;cellular response to stimulus#GO:0051716;regulation of TORC1 signaling#GO:1903432;cell communication#GO:0007154;response to nutrient levels#GO:0031667;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to stress#GO:0006950;cellular response to nutrient levels#GO:0031669;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to starvation#GO:0042594;biological regulation#GO:0065007;cellular response to external stimulus#GO:0071496;cellular response to amino acid starvation#GO:0034198;cellular response to stress#GO:0033554 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;Seh1-associated complex#GO:0035859;intracellular membrane-bounded organelle#GO:0043231;vacuolar membrane#GO:0005774;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG167641|UniProtKB=T1EZL6 T1EZL6 20202016 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG104522|UniProtKB=T1EDM0 T1EDM0 20194672 PTHR14453:SF67 PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN POLY [ADP-RIBOSE] POLYMERASE molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;protein-macromolecule adaptor activity#GO:0030674 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG173662|UniProtKB=T1F735 T1F735 20204634 PTHR21180:SF32 ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY DOMAIN-CONTAINING PROTEIN 1 ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE FAMILY DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG181163|UniProtKB=T1FGP4 T1FGP4 20207993 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189820|UniProtKB=T1FRE2 T1FRE2 20211389 PTHR12348:SF26 TSC22 PROTEIN TSCT-1 HELRO|EnsemblGenome=HelroG70799|UniProtKB=T1G0C3 T1G0C3 20214521 PTHR22811:SF14 TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN LP01981P-RELATED endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;Golgi organization#GO:0007030;macromolecule localization#GO:0033036;transport#GO:0006810;endomembrane system organization#GO:0010256;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;organelle organization#GO:0006996;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;endoplasmic reticulum#GO:0005783;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG95830|UniProtKB=T1G979 T1G979 20217626 PTHR22726:SF1 METALLOENDOPEPTIDASE OMA1 METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;catabolic process#GO:0009056;organonitrogen compound catabolic process#GO:1901565;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;membrane#GO:0016020 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG168576|UniProtKB=T1F0R2 T1F0R2 20202412 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER FI01427P membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG64578|UniProtKB=T1FXW7 T1FXW7 20213665 PTHR45875:SF1 METHYLTRANSFERASE N6AMT1 METHYLTRANSFERASE N6AMT1 methyltransferase activity#GO:0008168;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;protein methyltransferase activity#GO:0008276;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757 methyltransferase complex#GO:0034708;protein-containing complex#GO:0032991;cellular anatomical entity#GO:0110165;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular anatomical structure#GO:0005622 methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG70308|UniProtKB=T1G044 T1G044 20214442 PTHR43840:SF13 MITOCHONDRIAL METAL TRANSPORTER 1-RELATED CATION EFFLUX PROTEIN CYTOPLASMIC DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG166232|UniProtKB=T1EXX4 T1EXX4 20201424 PTHR46115:SF1 THIOREDOXIN-LIKE PROTEIN 1 AT08565P protein-disulfide reductase activity#GO:0015035;disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 Oxidative stress response#P00046>TRX#P01122;Hypoxia response via HIF activation#P00030>Thioredoxin#P00825 HELRO|EnsemblGenome=HelroG193047|UniProtKB=T1FUK3 T1FUK3 20212499 PTHR23064:SF72 TROPONIN TROPONIN C, SKELETAL MUSCLE cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG98421|UniProtKB=T1G9M6 T1G9M6 20217772 PTHR47958:SF26 ATP-DEPENDENT RNA HELICASE DBP3 EUKARYOTIC INITIATION FACTOR 4A-III catalytic activity, acting on RNA#GO:0140098;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640;mRNA binding#GO:0003729 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;mRNA splicing, via spliceosome#GO:0000398;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;catalytic step 2 spliceosome#GO:0071013;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG88211|UniProtKB=T1G6Z9 T1G6Z9 20216846 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG156367|UniProtKB=T1ELU4 T1ELU4 20197544 PTHR43977:SF2 STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3 STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN HELRO|EnsemblGenome=HelroG185117|UniProtKB=T1FMF0 T1FMF0 20209999 PTHR21277:SF5 TRANSCRIPTIONAL ADAPTER 1 TRANSCRIPTIONAL ADAPTER 1 transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 SAGA-type complex#GO:0070461;peptidase complex#GO:1905368;histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;chromosome#GO:0005694;SAGA complex#GO:0000124 HELRO|EnsemblGenome=HelroG174675|UniProtKB=T1F8D0 T1F8D0 20205079 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG71408|UniProtKB=T1G0L0 T1G0L0 20214608 PTHR11208:SF45 RNA-BINDING PROTEIN RELATED SPLICING FACTOR 1 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of RNA splicing#GO:0043484;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of mRNA processing#GO:0050684;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;regulation of mRNA metabolic process#GO:1903311 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG188048|UniProtKB=T1FPK8 T1FPK8 20210755 PTHR11616:SF240 SODIUM/CHLORIDE DEPENDENT TRANSPORTER BLOATED TUBULES, ISOFORM B-RELATED localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;nitrogen compound transport#GO:0071705;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG105637|UniProtKB=T1EDW9 T1EDW9 20194771 PTHR12904:SF23 FAMILY NOT NAMED PROTEIN ZER-1 HOMOLOG HELRO|EnsemblGenome=HelroG171223|UniProtKB=T1F3Y7 T1F3Y7 20203536 PTHR44755:SF8 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide hormone binding#GO:0017046;hormone binding#GO:0042562;binding#GO:0005488;peptide binding#GO:0042277;amide binding#GO:0033218 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG170427|UniProtKB=T1F316 T1F316 20203215 PTHR43333:SF1 2-HACID_DH_C DOMAIN-CONTAINING PROTEIN D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG80617|UniProtKB=T1G429 T1G429 20215827 PTHR45698:SF1 TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG103283|UniProtKB=T1EDF3 T1EDF3 20194605 PTHR22948:SF65 TUDOR DOMAIN CONTAINING PROTEIN A-KINASE ANCHORING PROTEIN 1 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG91254|UniProtKB=T1G820 T1G820 20217217 PTHR21284:SF12 EG:80H7.2 PROTEIN EG:80H7.2 PROTEIN HELRO|EnsemblGenome=HelroG183260|UniProtKB=T1FJD8 T1FJD8 20208937 PTHR24119:SF0 ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6 ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6 nucleotide binding#GO:0000166;carbohydrate derivative binding#GO:0097367;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;amide binding#GO:0033218;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;lipid binding#GO:0008289;ion binding#GO:0043167;anion binding#GO:0043168 HELRO|EnsemblGenome=HelroG81129|UniProtKB=T1G498 T1G498 20215896 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG171664|UniProtKB=T1F4I9 T1F4I9 20203738 PTHR11819:SF195 SOLUTE CARRIER FAMILY 5 SODIUM_GLUCOSE COTRANSPORTER 4 inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;carbohydrate transmembrane transporter activity#GO:0015144;symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;sugar transmembrane transporter activity#GO:0051119;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;monoatomic ion transmembrane transporter activity#GO:0015075;inorganic cation transmembrane transporter activity#GO:0022890;solute:monoatomic cation symporter activity#GO:0015294 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG134573|UniProtKB=T1EI53 T1EI53 20196253 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG163279|UniProtKB=T1ETV2 T1ETV2 20200002 PTHR13077:SF6 SELENOPROTEIN F SELENOPROTEIN F oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;endoplasmic reticulum lumen#GO:0005788;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG158877|UniProtKB=T1ENC9 T1ENC9 20198079 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169888|UniProtKB=T1F2E7 T1F2E7 20202997 PTHR14596:SF72 ZINC FINGER PROTEIN ZINC FINGER PROTEIN MSN2-RELATED cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to nutrient levels#GO:0031667;response to extracellular stimulus#GO:0009991;response to stress#GO:0006950;response to starvation#GO:0042594 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185366|UniProtKB=T1FMQ5 T1FMQ5 20210104 PTHR45684:SF2 RE74312P RE74312P pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;membrane organization#GO:0061024;transport#GO:0006810;regulation of localization#GO:0032879;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789;regulation of transport#GO:0051049;regulation of protein-containing complex assembly#GO:0043254;establishment of localization#GO:0051234;regulation of cellular component biogenesis#GO:0044087;positive regulation of protein transport#GO:0051222;vesicle organization#GO:0016050;regulation of protein transport#GO:0051223;positive regulation of biological process#GO:0048518;regulation of protein localization#GO:0032880;positive regulation of establishment of protein localization#GO:1904951;regulation of organelle organization#GO:0033043;positive regulation of transport#GO:0051050;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;Golgi vesicle transport#GO:0048193;regulation of cellular localization#GO:0060341;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;regulation of cellular process#GO:0050794;organelle organization#GO:0006996;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;positive regulation of protein localization#GO:1903829;regulation of establishment of protein localization#GO:0070201 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;ER to Golgi transport vesicle membrane#GO:0012507;COPII-coated ER to Golgi transport vesicle#GO:0030134;endoplasmic reticulum exit site#GO:0070971;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;vesicle coat#GO:0030120;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;transport vesicle membrane#GO:0030658;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;coated vesicle membrane#GO:0030662;membrane coat#GO:0030117;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;coated membrane#GO:0048475;transport vesicle#GO:0030133;cytoplasmic vesicle membrane#GO:0030659;endoplasmic reticulum#GO:0005783 HELRO|EnsemblGenome=HelroG70625|UniProtKB=T1G094 T1G094 20214492 PTHR24353:SF153 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;cytosol#GO:0005829;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Enkephalin release#P05913>PKA#P05972;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Endothelin signaling pathway#P00019>PKA#P00570;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059 HELRO|EnsemblGenome=HelroG163335|UniProtKB=T1ETX4 T1ETX4 20200024 PTHR10915:SF1 SYNDECAN SYNDECAN cell motility#GO:0048870;cellular process#GO:0009987;cell migration#GO:0016477 cell surface#GO:0009986;cellular anatomical entity#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG66362|UniProtKB=T1FYK2 T1FYK2 20213900 PTHR12241:SF161 TUBULIN POLYGLUTAMYLASE TUBULIN POLYGLUTAMYLASE TTLL6 cytoskeletal protein binding#GO:0008092;ligase activity#GO:0016874;protein binding#GO:0005515;tubulin binding#GO:0015631;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;microtubule cytoskeleton organization#GO:0000226;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;cellular component organization#GO:0016043;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;nitrogen compound metabolic process#GO:0006807;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;cilium#GO:0005929;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG173907|UniProtKB=T1F7C8 T1F7C8 20204727 PTHR46880:SF5 RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185178|UniProtKB=T1FMH2 T1FMH2 20210021 PTHR19139:SF199 AQUAPORIN TRANSPORTER MIP17260P cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG164848|UniProtKB=T1EVW0 T1EVW0 20200710 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG185324|UniProtKB=T1FMN9 T1FMN9 20210088 PTHR22093:SF0 LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1 LEUKOCYTE RECEPTOR CLUSTER MEMBER 1 HELRO|EnsemblGenome=HelroG160521|UniProtKB=T1EQC8 T1EQC8 20198778 PTHR15606:SF4 DNAJ HOMOLOG SUBFAMILY C MEMBER 8/LIPOPOLYSACCHARIDE SPECIFIC RESPONSE-7-RELATED DNAJ HOMOLOG SUBFAMILY C MEMBER 8 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG190480|UniProtKB=T1FS09 T1FS09 20211606 PTHR15067:SF5 E3 UBIQUITIN-PROTEIN LIGASE RNF8 E3 UBIQUITIN-PROTEIN LIGASE AMFR transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 signal transduction#GO:0007165;endoplasmic reticulum unfolded protein response#GO:0030968;macromolecule modification#GO:0043412;protein catabolic process#GO:0030163;organonitrogen compound catabolic process#GO:1901565;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;modification-dependent macromolecule catabolic process#GO:0043632;regulation of biological process#GO:0050789;nitrogen compound metabolic process#GO:0006807;response to unfolded protein#GO:0006986;proteolysis#GO:0006508;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;response to organic substance#GO:0010033;macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;cellular response to chemical stimulus#GO:0070887;protein modification by small protein conjugation or removal#GO:0070647;macromolecule metabolic process#GO:0043170;cellular response to organic substance#GO:0071310;protein K48-linked ubiquitination#GO:0070936;organonitrogen compound metabolic process#GO:1901564;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to topologically incorrect protein#GO:0035967;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;cellular response to unfolded protein#GO:0034620;response to topologically incorrect protein#GO:0035966;biological regulation#GO:0065007;cellular response to stress#GO:0033554 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185307|UniProtKB=T1FMN2 T1FMN2 20210081 PTHR48078:SF19 THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED ACT DOMAIN-CONTAINING PROTEIN lyase activity#GO:0016829;catalytic activity#GO:0003824 branched-chain amino acid metabolic process#GO:0009081;organonitrogen compound catabolic process#GO:1901565;biosynthetic process#GO:0009058;branched-chain amino acid biosynthetic process#GO:0009082;carboxylic acid biosynthetic process#GO:0046394;amino acid catabolic process#GO:0009063;nitrogen compound metabolic process#GO:0006807;alpha-amino acid metabolic process#GO:1901605;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;L-amino acid metabolic process#GO:0170033;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248;organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;alpha-amino acid biosynthetic process#GO:1901607;aspartate family amino acid metabolic process#GO:0009066;small molecule biosynthetic process#GO:0044283;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281 dehydratase#PC00091;lyase#PC00144 Isoleucine biosynthesis#P02748>Threonine dehydratase#P02995 HELRO|EnsemblGenome=HelroG158306|UniProtKB=T1EMM4 T1EMM4 20197824 PTHR43785:SF14 GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE GLUTAMINE SYNTHETASE metabolite interconversion enzyme#PC00262;ligase#PC00142 HELRO|EnsemblGenome=HelroG186943|UniProtKB=T1FP46 T1FP46 20210593 PTHR14248:SF18 CYCLIN Y, ISOFORM A CYCLIN Y, ISOFORM A cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG194975|UniProtKB=T1FWM2 T1FWM2 20213217 PTHR38709:SF1 SI:CH73-193C12.2-RELATED DREBRIN localization#GO:0051179;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;cellular process#GO:0009987;macromolecule localization#GO:0033036;maintenance of location#GO:0051235;protein localization#GO:0008104 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG192409|UniProtKB=T1FTX4 T1FTX4 20212271 PTHR18945:SF865 NEUROTRANSMITTER GATED ION CHANNEL NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA7, ISOFORM E ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG186615|UniProtKB=T1FP16 T1FP16 20210563 PTHR45695:SF15 LEUCOKININ RECEPTOR-RELATED OPSIN RH2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Rhodopsin#P00747 HELRO|EnsemblGenome=HelroG195027|UniProtKB=T1FWN9 T1FWN9 20213234 PTHR23113:SF312 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE, ISOFORM E nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;Ras protein signal transduction#GO:0007265;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG190158|UniProtKB=T1FRR1 T1FRR1 20211508 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG172715|UniProtKB=T1F5U3 T1F5U3 20204192 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG90454|UniProtKB=T1G7R6 T1G7R6 20217113 PTHR19300:SF57 BETA-1,4-GALACTOSYLTRANSFERASE BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE galactosyltransferase activity#GO:0008378;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycosylation#GO:0070085;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG163010|UniProtKB=T1ETK1 T1ETK1 20199901 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191040|UniProtKB=T1FSJ1 T1FSJ1 20211788 PTHR12431:SF19 SORTING NEXIN 17 AND 27 SORTING NEXIN-27 lipid binding#GO:0008289;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;binding#GO:0005488 endosomal transport#GO:0016197;localization within membrane#GO:0051668;cellular localization#GO:0051641;vesicle-mediated transport to the plasma membrane#GO:0098876;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;endocytic recycling#GO:0032456;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;early endosome#GO:0005769;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG176222|UniProtKB=T1FAB3 T1FAB3 20205762 PTHR12990:SF5 ARMET-LIKE PROTEIN MESENCEPHALIC ASTROCYTE-DERIVED NEUROTROPHIC FACTOR HOMOLOG HELRO|EnsemblGenome=HelroG191273|UniProtKB=T1FST9 T1FST9 20211886 PTHR24023:SF1106 COLLAGEN ALPHA VIKING, ISOFORM A structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922 HELRO|EnsemblGenome=HelroG93421|UniProtKB=T1G8V7 T1G8V7 20217504 PTHR11829:SF377 FORKHEAD BOX PROTEIN FORK HEAD DOMAIN-CONTAINING PROTEIN FD4-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;anatomical structure morphogenesis#GO:0009653;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG84756|UniProtKB=T1G5N3 T1G5N3 20216380 PTHR11567:SF211 ACID PHOSPHATASE-RELATED PROSTATIC ACID PHOSPHATASE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 cellular metabolic process#GO:0044237;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;dephosphorylation#GO:0016311;metabolic process#GO:0008152 metabolite interconversion enzyme#PC00262;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG194514|UniProtKB=T1FW52 T1FW52 20213048 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161397|UniProtKB=T1ERF8 T1ERF8 20199158 PTHR11444:SF1 ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE FUMARATE HYDRATASE, MITOCHONDRIAL carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;catalytic activity#GO:0003824;hydro-lyase activity#GO:0016836 oxoacid metabolic process#GO:0043436;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;dicarboxylic acid metabolic process#GO:0043648;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;carboxylic acid metabolic process#GO:0019752;energy derivation by oxidation of organic compounds#GO:0015980;tricarboxylic acid cycle#GO:0006099;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 lyase#PC00144 TCA cycle#P00051>Fumarase#P01271 HELRO|EnsemblGenome=HelroG170511|UniProtKB=T1F354 T1F354 20203253 PTHR13723:SF281 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE PAPILIN metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG193984|UniProtKB=T1FVJ4 T1FVJ4 20212840 PTHR45678:SF5 MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED AT03939P-RELATED L-glutamate transmembrane transporter activity#GO:0005313;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;organic acid transmembrane transporter activity#GO:0005342;L-amino acid transmembrane transporter activity#GO:0015179;organic anion transmembrane transporter activity#GO:0008514;amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;acidic amino acid transmembrane transporter activity#GO:0015172 cellular respiration#GO:0045333;L-amino acid transport#GO:0015807;transmembrane transport#GO:0055085;dicarboxylic acid transport#GO:0006835;organic anion transport#GO:0015711;acidic amino acid transport#GO:0015800;amino acid transport#GO:0006865;organic acid transport#GO:0015849;transport#GO:0006810;generation of precursor metabolites and energy#GO:0006091;nitrogen compound transport#GO:0071705;electron transport chain#GO:0022900;carboxylic acid transport#GO:0046942;cellular metabolic process#GO:0044237;cellular process#GO:0009987;energy derivation by oxidation of organic compounds#GO:0015980;carboxylic acid transmembrane transport#GO:1905039;localization#GO:0051179;mitochondrial transport#GO:0006839;organic substance transport#GO:0071702;amino acid transmembrane transport#GO:0003333;establishment of localization#GO:0051234;L-alpha-amino acid transmembrane transport#GO:1902475;respiratory electron transport chain#GO:0022904;C4-dicarboxylate transport#GO:0015740;aspartate transmembrane transport#GO:0015810;organic acid transmembrane transport#GO:1903825;mitochondrial transmembrane transport#GO:1990542;metabolic process#GO:0008152 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG90253|UniProtKB=T1G7N4 T1G7N4 20217081 PTHR12127:SF7 MUCOLIPIN SD02261P calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;ligand-gated monoatomic ion channel activity#GO:0015276;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;inorganic cation transmembrane transporter activity#GO:0022890;ligand-gated channel activity#GO:0022834 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG190865|UniProtKB=T1FSD3 T1FSD3 20211730 PTHR43811:SF19 FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA 39 KDA FK506-BINDING NUCLEAR PROTEIN peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 chaperone#PC00072 TGF-beta signaling pathway#P00052>FKBP12#P01288 HELRO|EnsemblGenome=HelroG193617|UniProtKB=T1FV67 T1FV67 20212713 PTHR11804:SF83 PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED LD37516P hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;peptide metabolic process#GO:0006518;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG66838|UniProtKB=T1FYR8 T1FYR8 20213966 PTHR19853:SF0 WD REPEAT CONTAINING PROTEIN 3 WDR3 WD REPEAT-CONTAINING PROTEIN 3 snoRNA binding#GO:0030515;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981;90S preribosome#GO:0030686;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG191412|UniProtKB=T1FSY7 T1FSY7 20211934 PTHR44414:SF1 PROTEIN NEDD1 PROTEIN NEDD1 cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;microtubule cytoskeleton organization#GO:0000226;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;microtubule polymerization or depolymerization#GO:0031109;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;microtubule-based process#GO:0007017;microtubule polymerization#GO:0046785;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;protein polymerization#GO:0051258;cell cycle#GO:0007049;cytoskeleton organization#GO:0007010;microtubule nucleation#GO:0007020 spindle pole#GO:0000922;microtubule organizing center#GO:0005815;cellular anatomical entity#GO:0110165;centriole#GO:0005814;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;centrosome#GO:0005813;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929;spindle#GO:0005819 HELRO|EnsemblGenome=HelroG66135|UniProtKB=T1FYH3 T1FYH3 20213871 PTHR11636:SF70 POU DOMAIN INHIBITORY POU PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG96289|UniProtKB=T1G9B2 T1G9B2 20217659 PTHR11630:SF26 DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER DNA REPLICATION LICENSING FACTOR MCM7 ATP-dependent activity, acting on DNA#GO:0008094;nucleic acid binding#GO:0003676;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;single-stranded DNA binding#GO:0003697;DNA binding#GO:0003677;catalytic activity, acting on a nucleic acid#GO:0140640;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097;single-stranded DNA helicase activity#GO:0017116 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;double-strand break repair#GO:0006302;nucleobase-containing compound metabolic process#GO:0006139;DNA geometric change#GO:0032392;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;recombinational repair#GO:0000725;DNA duplex unwinding#GO:0032508;DNA-templated DNA replication#GO:0006261;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;DNA unwinding involved in DNA replication#GO:0006268;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;double-strand break repair via homologous recombination#GO:0000724;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;DNA conformation change#GO:0071103;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;double-strand break repair via break-induced replication#GO:0000727;organelle organization#GO:0006996;chromosome organization#GO:0051276;cellular response to stress#GO:0033554;DNA replication#GO:0006260;DNA replication initiation#GO:0006270;DNA strand elongation involved in DNA replication#GO:0006271;DNA metabolic process#GO:0006259 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;MCM complex#GO:0042555;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG181789|UniProtKB=T1FHB9 T1FHB9 20208218 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG140562|UniProtKB=T1EJ14 T1EJ14 20196564 PTHR11824:SF5 VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT CA2+-CHANNEL-PROTEIN-BETA-SUBUNIT, ISOFORM L calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated calcium channel activity#GO:0005245;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;regulation of metal ion transport#GO:0010959;trans-synaptic signaling#GO:0099537;regulation of calcium ion transport#GO:0051924;regulation of localization#GO:0032879;regulation of monoatomic cation transmembrane transport#GO:1904062;cellular component organization#GO:0016043;cell communication#GO:0007154;cellular process#GO:0009987;neuromuscular junction development#GO:0007528;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;synapse organization#GO:0050808;regulation of transport#GO:0051049;chemical synaptic transmission#GO:0007268;anterograde trans-synaptic signaling#GO:0098916;regulation of molecular function#GO:0065009;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;biological regulation#GO:0065007;synaptic signaling#GO:0099536;regulation of monoatomic ion transmembrane transporter activity#GO:0032412;regulation of monoatomic ion transport#GO:0043269;regulation of transmembrane transporter activity#GO:0022898;regulation of transporter activity#GO:0032409;cell-cell signaling#GO:0007267;signaling#GO:0023052 voltage-gated calcium channel complex#GO:0005891;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;calcium channel complex#GO:0034704;membrane#GO:0016020;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227;voltage-gated ion channel#PC00241 Thyrotropin-releasing hormone receptor signaling pathway#P04394>Ca2+ channel#P04587 HELRO|EnsemblGenome=HelroG167737|UniProtKB=T1EZQ6 T1EZQ6 20202056 PTHR10476:SF40 CHARGED MULTIVESICULAR BODY PROTEIN CHARGED MULTIVESICULAR BODY PROTEIN 2B endosomal transport#GO:0016197;cellular localization#GO:0051641;macromolecule localization#GO:0033036;vacuolar transport#GO:0007034;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;late endosome to vacuole transport#GO:0045324;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;endosome transport via multivesicular body sorting pathway#GO:0032509;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endosome membrane#GO:0010008;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG184236|UniProtKB=T1FKT7 T1FKT7 20209436 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG104700|UniProtKB=T1EDN2 T1EDN2 20194684 PTHR21367:SF1 ARGININE-TRNA-PROTEIN TRANSFERASE 1 ARGINYL-TRNA--PROTEIN TRANSFERASE 1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 translational protein#PC00263 HELRO|EnsemblGenome=HelroG155848|UniProtKB=T1ELN3 T1ELN3 20197483 PTHR12315:SF1 BICOID-INTERACTING PROTEIN RELATED RNA 5'-MONOPHOSPHATE METHYLTRANSFERASE catalytic activity, acting on RNA#GO:0140098;transferase activity#GO:0016740;O-methyltransferase activity#GO:0008171;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;RNA methyltransferase activity#GO:0008173 negative regulation of gene expression#GO:0010629;positive regulation of gene expression#GO:0010628;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of RNA metabolic process#GO:0051253;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG65229|UniProtKB=T1FY48 T1FY48 20213746 PTHR23076:SF97 METALLOPROTEASE M41 FTSH ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1 hydrolase activity#GO:0016787;peptidase activity#GO:0008233;ATP-dependent activity#GO:0140657;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG168657|UniProtKB=T1F0U3 T1F0U3 20202443 PTHR46251:SF3 RUN DOMAIN-CONTAINING 3 PROTEIN RUNDC3 RUN DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG153470|UniProtKB=T1EL78 T1EL78 20197328 PTHR13864:SF10 T-CELL ACUTE LYMPHOCYTIC LEUKEMIA/STEM CELL LEUKEMIA-RELATED HELIX-LOOP-HELIX PROTEIN 2 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG162052|UniProtKB=T1ES70 T1ES70 20199420 PTHR18952:SF208 CARBONIC ANHYDRASE CARBONIC ANHYDRASE XA-RELATED carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 cellular metabolic process#GO:0044237;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG177435|UniProtKB=T1FBP6 T1FBP6 20206245 PTHR47160:SF5 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG187969|UniProtKB=T1FPI6 T1FPI6 20210733 PTHR13251:SF3 EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10 localization#GO:0051179;endosomal transport#GO:0016197;cellular localization#GO:0051641;establishment of localization#GO:0051234;intra-Golgi vesicle-mediated transport#GO:0006891;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147 endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle tethering complex#GO:0099023;TRAPP complex#GO:0030008;Golgi apparatus#GO:0005794;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG166879|UniProtKB=T1EYP5 T1EYP5 20201695 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG99097|UniProtKB=T1G9Q9 T1G9Q9 20217805 PTHR10997:SF8 IMPORTIN-7, 8, 11 EXPORTIN-2 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;protein import into nucleus#GO:0006606;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;protein export from nucleus#GO:0006611;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365;nuclear transport#GO:0051169;import into nucleus#GO:0051170 envelope#GO:0031975;cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG73175|UniProtKB=T1G1B2 T1G1B2 20214860 PTHR10851:SF0 PYRIDOXINE-5-PHOSPHATE OXIDASE PYRIDOXINE-5'-PHOSPHATE OXIDASE oxidase#PC00175;oxidoreductase#PC00176 Pyridoxal-5-phosphate biosynthesis#P02759>Pyridoxine-5-phosphate oxidase#P03061;Pyridoxal phosphate salvage pathway#P02770>Pyridoxine-5-phosphate oxidase#P03123;Vitamin B6 metabolism#P02787>Pyridoxamine phosphate oxidase#P03236;Pyridoxal phosphate salvage pathway#P02770>Pyridoxamine-5-phosphate oxidase#P03120 HELRO|EnsemblGenome=HelroG114555|UniProtKB=T1EG28 T1EG28 20195530 PTHR24115:SF929 KINESIN-RELATED KINESIN-LIKE PROTEIN AT 31E, ISOFORM A pyrophosphatase activity#GO:0016462;cytoskeletal protein binding#GO:0008092;microtubule motor activity#GO:0003777;tubulin binding#GO:0015631;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;cytoskeletal motor activity#GO:0003774;microtubule binding#GO:0008017;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;microtubule associated complex#GO:0005875;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG69604|UniProtKB=T1FZX1 T1FZX1 20214369 PTHR45942:SF1 PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1 PROTEIN PHOSPHATASE 3 REGULATORY SUBUNIT B, ALPHA phosphatase binding#GO:0019902;phosphatase regulator activity#GO:0019208;binding#GO:0005488;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888;protein binding#GO:0005515;enzyme binding#GO:0019899;enzyme regulator activity#GO:0030234 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;calcium-mediated signaling#GO:0019722;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;calcineurin-mediated signaling#GO:0097720;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;cell communication#GO:0007154;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;dephosphorylation#GO:0016311;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 protein serine/threonine phosphatase complex#GO:0008287;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;catalytic complex#GO:1902494 Wnt signaling pathway#P00057>Calcineurin#P01446 HELRO|EnsemblGenome=HelroG151764|UniProtKB=T1EKM0 T1EKM0 20197120 PTHR21255:SF65 T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN TCTEX1 DOMAIN-CONTAINING PROTEIN 2 protein binding#GO:0005515;binding#GO:0005488 microtubule-based movement#GO:0007018;cellular process#GO:0009987;microtubule-based process#GO:0007017 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;microtubule cytoskeleton#GO:0015630;dynein complex#GO:0030286;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic dynein complex#GO:0005868;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG103632|UniProtKB=T1EDG7 T1EDG7 20194619 PTHR43814:SF1 ARGININOSUCCINATE LYASE ARGININOSUCCINATE LYASE lyase activity#GO:0016829;catalytic activity#GO:0003824 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;proteinogenic amino acid biosynthetic process#GO:0170038;arginine metabolic process#GO:0006525;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;alpha-amino acid biosynthetic process#GO:1901607;nitrogen compound metabolic process#GO:0006807;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;small molecule biosynthetic process#GO:0044283;L-amino acid biosynthetic process#GO:0170034;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 lyase#PC00144 Arginine biosynthesis#P02728>argininosuccinate lyase#P02841 HELRO|EnsemblGenome=HelroG84684|UniProtKB=T1G5M1 T1G5M1 20216368 PTHR13902:SF12 SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG77232|UniProtKB=T1G2U8 T1G2U8 20215396 PTHR45787:SF1 LD11652P LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;protein binding#GO:0005515;transcription factor binding#GO:0008134;DNA-binding transcription factor binding#GO:0140297 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG188804|UniProtKB=T1FQD7 T1FQD7 20211034 PTHR22536:SF1 LUNG CANCER METASTASIS-RELATED LCMR1 PROTEIN MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19 protein binding#GO:0005515;transcription factor binding#GO:0008134;binding#GO:0005488 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG111473|UniProtKB=T1EFB5 T1EFB5 20195267 PTHR45639:SF3 HSC70CB, ISOFORM G-RELATED HYPOXIA UP-REGULATED PROTEIN 1 response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;endoplasmic reticulum unfolded protein response#GO:0030968;response to endoplasmic reticulum stress#GO:0034976;cellular response to chemical stimulus#GO:0070887;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to topologically incorrect protein#GO:0035967;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;response to topologically incorrect protein#GO:0035966;response to unfolded protein#GO:0006986;cellular response to unfolded protein#GO:0034620;biological regulation#GO:0065007;cellular response to stress#GO:0033554;signaling#GO:0023052 cytoplasm#GO:0005737;endoplasmic reticulum protein-containing complex#GO:0140534;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 Hsp70 family chaperone#PC00027 HELRO|EnsemblGenome=HelroG68163|UniProtKB=T1FZB1 T1FZB1 20214159 PTHR12419:SF4 OTU DOMAIN CONTAINING PROTEIN OTU DOMAIN-CONTAINING PROTEIN 5 cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG164367|UniProtKB=T1EVB7 T1EVB7 20200517 PTHR23048:SF49 MYOSIN LIGHT CHAIN 1, 3 FI08416P-RELATED intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;myosin complex#GO:0016459;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG69490|UniProtKB=T1FZV9 T1FZV9 20214357 PTHR24169:SF25 NUCLEAR FACTOR NF-KAPPA-B PROTEIN DORSAL-RELATED IMMUNITY FACTOR DIF-RELATED DNA-binding transcription factor#PC00218;Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 Toll pathway-drosophila#P06217>DL#P06344;Toll receptor signaling pathway#P00054>NFkappaB#P01354 HELRO|EnsemblGenome=HelroG62173|UniProtKB=T1FWW5 T1FWW5 20213313 PTHR20913:SF7 TBC1 DOMAIN FAMILY MEMBER 20/GTPASE RE60063P nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG123334|UniProtKB=T1EGX6 T1EGX6 20195826 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG191313|UniProtKB=T1FSV6 T1FSV6 20211903 PTHR46165:SF2 SET AND MYND DOMAIN-CONTAINING PROTEIN 4 SET AND MYND DOMAIN-CONTAINING PROTEIN 4 enzyme binding#GO:0019899;protein binding#GO:0005515;histone deacetylase binding#GO:0042826;binding#GO:0005488 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG177763|UniProtKB=T1FC76 T1FC76 20206425 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG175918|UniProtKB=T1F9W0 T1F9W0 20205609 PTHR31802:SF3 32 KDA HEAT SHOCK PROTEIN-RELATED 32 KDA HEAT SHOCK PROTEIN intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG160629|UniProtKB=T1EQI7 T1EQI7 20198837 PTHR16112:SF16 METHYL-CPG BINDING PROTEIN, DROSOPHILA SIX-BANDED, ISOFORM H protein-containing complex binding#GO:0044877;chromatin binding#GO:0003682;binding#GO:0005488 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG74472|UniProtKB=T1G1R5 T1G1R5 20215013 PTHR12429:SF8 NEURALIZED NEURALIZED-LIKE PROTEIN 2 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Notch signaling pathway#P00045>Neuralized#P01117 HELRO|EnsemblGenome=HelroG66045|UniProtKB=T1FYG2 T1FYG2 20213860 PTHR14003:SF19 TRANSCRIPTIONAL REPRESSOR PROTEIN YY YY2 TRANSCRIPTION FACTOR sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;PcG protein complex#GO:0031519;protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG76352|UniProtKB=T1G2I8 T1G2I8 20215286 PTHR21230:SF26 VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A molecular adaptor activity#GO:0060090;protein binding#GO:0005515;SNAP receptor activity#GO:0005484;binding#GO:0005488;SNARE binding#GO:0000149;protein-macromolecule adaptor activity#GO:0030674 localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;vesicle fusion#GO:0006906;membrane fusion#GO:0061025;establishment of localization#GO:0051234;membrane organization#GO:0061024;organelle organization#GO:0006996;organelle membrane fusion#GO:0090174;transport#GO:0006810;vesicle-mediated transport#GO:0016192;vesicle organization#GO:0016050;cellular component organization#GO:0016043;cellular process#GO:0009987;organelle fusion#GO:0048284 bounding membrane of organelle#GO:0098588;endosome#GO:0005768;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular membrane-bounded organelle#GO:0043231;SNARE complex#GO:0031201;late endosome membrane#GO:0031902;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endosome membrane#GO:0010008;vesicle#GO:0031982;intracellular organelle#GO:0043229;transport vesicle membrane#GO:0030658;endoplasmic reticulum subcompartment#GO:0098827;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;membrane protein complex#GO:0098796;ER to Golgi transport vesicle membrane#GO:0012507;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;membrane#GO:0016020;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;coated vesicle membrane#GO:0030662;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 SNARE protein#PC00034 Metabotropic glutamate receptor group III pathway#P00039>SNARE Complex#P01042 HELRO|EnsemblGenome=HelroG177764|UniProtKB=T1FC77 T1FC77 20206426 PTHR23309:SF49 3-HYDROXYACYL-COA DEHYROGENASE PEROXISOMAL BIFUNCTIONAL ENZYME oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;lipid oxidation#GO:0034440;cellular metabolic process#GO:0044237;lipid catabolic process#GO:0016042;lipid modification#GO:0030258;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;fatty acid catabolic process#GO:0009062;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;fatty acid metabolic process#GO:0006631;small molecule catabolic process#GO:0044282;fatty acid beta-oxidation#GO:0006635;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;carboxylic acid metabolic process#GO:0019752;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG191562|UniProtKB=T1FT31 T1FT31 20211978 PTHR46735:SF3 CALPAIN, SMALL SUBUNIT 1 A-RELATED CALPAIN SMALL SUBUNIT 1-RELATED Huntington disease#P00029>Calpain#P00788 HELRO|EnsemblGenome=HelroG159813|UniProtKB=T1EPF4 T1EPF4 20198454 PTHR45632:SF17 LD33804P KELCH-LIKE PROTEIN 31 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG189810|UniProtKB=T1FRD9 T1FRD9 20211386 PTHR13976:SF76 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED AT27789P ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG106306|UniProtKB=T1EE17 T1EE17 20194819 PTHR46295:SF1 ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44 ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44 isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;protein disulfide isomerase activity#GO:0003756 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein folding#GO:0006457;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG177274|UniProtKB=T1FBF8 T1FBF8 20206157 PTHR47763:SF1 ALPHA-PROTEIN KINASE VWKA DUF659 DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-serine modification#GO:0018209;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG101539|UniProtKB=T1ED53 T1ED53 20194505 PTHR24215:SF37 RHO-GTPASE-ACTIVATING PROTEIN LRG1 LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;organelle organization#GO:0006996 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG109229|UniProtKB=T1EER7 T1EER7 20195069 PTHR12083:SF9 BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;nucleic acid binding#GO:0003676;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;hydrolase activity#GO:0016787;transferase activity, transferring phosphorus-containing groups#GO:0016772;double-stranded DNA binding#GO:0003690;kinase activity#GO:0016301;phosphoric ester hydrolase activity#GO:0042578 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 nucleotide phosphatase#PC00173 HELRO|EnsemblGenome=HelroG91412|UniProtKB=T1G834 T1G834 20217231 PTHR10807:SF8 MYOTUBULARIN-RELATED PHOSPHATIDYLINOSITOL-3-PHOSPHATE PHOSPHATASE hydrolase activity#GO:0016787;phosphatidylinositol-3,5-bisphosphate phosphatase activity#GO:0106018;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 lipid metabolic process#GO:0006629;phospholipid dephosphorylation#GO:0046839;phosphatidylinositol dephosphorylation#GO:0046856;cellular metabolic process#GO:0044237;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;lipid modification#GO:0030258;cellular process#GO:0009987;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;dephosphorylation#GO:0016311;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG162691|UniProtKB=T1ET07 T1ET07 20199707 PTHR19303:SF71 TRANSPOSON ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG180805|UniProtKB=T1FGA9 T1FGA9 20207858 PTHR14312:SF5 CREB/ATF BZIP TRANSCRIPTION FACTOR RBP-JKAPPA IPT DOMAIN-CONTAINING PROTEIN sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG181813|UniProtKB=T1FHD2 T1FHD2 20208231 PTHR12766:SF7 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DEATH DOMAIN-ASSOCIATED PROTEIN 6 FAS signaling pathway#P00020>DAXX#P00602;Apoptosis signaling pathway#P00006>DAXX#P00296 HELRO|EnsemblGenome=HelroG93768|UniProtKB=T1G8X7 T1G8X7 20217524 PTHR12691:SF10 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23 positive regulation of gene expression#GO:0010628;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG164159|UniProtKB=T1EV07 T1EV07 20200407 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG78455|UniProtKB=T1G3B9 T1G3B9 20215567 PTHR12969:SF7 NGD5/OSM-6/IFT52 INTRAFLAGELLAR TRANSPORT PROTEIN 52 HOMOLOG HELRO|EnsemblGenome=HelroG68342|UniProtKB=T1FZD3 T1FZD3 20214181 PTHR42985:SF40 SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER LD47995P-RELATED symporter activity#GO:0015293;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;monoatomic cation transport#GO:0006812;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG63861|UniProtKB=T1FXL2 T1FXL2 20213560 PTHR24112:SF9 LEUCINE-RICH REPEAT, ISOFORM F-RELATED PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 37 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG165793|UniProtKB=T1EXA5 T1EXA5 20201205 PTHR11614:SF87 PHOSPHOLIPASE-RELATED MONOGLYCERIDE LIPASE hydrolase activity#GO:0016787;lipase activity#GO:0016298;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 cellular anatomical entity#GO:0110165;membrane#GO:0016020 phospholipase#PC00186;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG103444|UniProtKB=T1EDG2 T1EDG2 20194614 PTHR24320:SF283 RETINOL DEHYDROGENASE RETINOL DEHYDROGENASE 11 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG179399|UniProtKB=T1FEN4 T1FEN4 20207283 PTHR12011:SF347 ADHESION G-PROTEIN COUPLED RECEPTOR FI21270P1-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG167825|UniProtKB=T1EZU4 T1EZU4 20202094 PTHR45969:SF69 RING ZINC FINGER PROTEIN-RELATED FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG182608|UniProtKB=T1FIG9 T1FIG9 20208618 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG107917|UniProtKB=T1EED8 T1EED8 20194940 PTHR11767:SF102 INWARD RECTIFIER POTASSIUM CHANNEL INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of localization#GO:0032879;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;import across plasma membrane#GO:0098739;regulation of transport#GO:0051049;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;regulation of monoatomic ion transport#GO:0043269;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;potassium ion transport#GO:0006813;potassium ion import across plasma membrane#GO:1990573 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG92396|UniProtKB=T1G8F6 T1G8F6 20217353 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG67877|UniProtKB=T1FZ68 T1FZ68 20214116 PTHR24230:SF75 G-PROTEIN COUPLED RECEPTOR RELAXIN FAMILY PEPTIDE RECEPTOR 3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;neuropeptide signaling pathway#GO:0007218;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG167021|UniProtKB=T1EYW7 T1EYW7 20201767 PTHR15126:SF4 SH3-BINDING SH3 DOMAIN-BINDING PROTEIN 2 HELRO|EnsemblGenome=HelroG66182|UniProtKB=T1FYI1 T1FYI1 20213879 PTHR21600:SF87 MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE RNA PSEUDOURIDYLATE SYNTHASE DOMAIN-CONTAINING PROTEIN 1 isomerase activity#GO:0016853;intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA modification#GO:0009451;rRNA modification#GO:0000154;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;ribosome biogenesis#GO:0042254;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;pseudouridine synthesis#GO:0001522;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG110320|UniProtKB=T1EF13 T1EF13 20195165 PTHR10925:SF5 N-ACETYLTRANSFERASE 10 RNA CYTIDINE ACETYLTRANSFERASE tRNA binding#GO:0000049;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;acetyltransferase activity#GO:0016407;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;N-acyltransferase activity#GO:0016410 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA modification#GO:0009451;rRNA modification#GO:0000154;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;ribosome biogenesis#GO:0042254;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG193208|UniProtKB=T1FUR3 T1FUR3 20212559 PTHR24250:SF27 CHYMOTRYPSIN-RELATED ELASTASE 2 LIKE hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG188606|UniProtKB=T1FQ63 T1FQ63 20210960 PTHR16007:SF15 EPIDIDYMAL MEMBRANE PROTEIN E9-RELATED TRANSMEMBRANE PROTEIN 45B HELRO|EnsemblGenome=HelroG192511|UniProtKB=T1FU15 T1FU15 20212311 PTHR11616:SF321 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;organic acid:sodium symporter activity#GO:0005343;organic acid transmembrane transporter activity#GO:0005342;symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;organic anion transmembrane transporter activity#GO:0008514;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;amino acid:sodium symporter activity#GO:0005283;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;amino acid transmembrane transporter activity#GO:0015171;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;organic anion transport#GO:0015711;amino acid transport#GO:0006865;organic acid transport#GO:0015849;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;nitrogen compound transport#GO:0071705;carboxylic acid transport#GO:0046942;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;amino acid import across plasma membrane#GO:0089718;carboxylic acid transmembrane transport#GO:1905039;localization#GO:0051179;organic substance transport#GO:0071702;import across plasma membrane#GO:0098739;amino acid transmembrane transport#GO:0003333;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transport#GO:0006812;organic acid transmembrane transport#GO:1903825;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>CHT1#P01084 HELRO|EnsemblGenome=HelroG188989|UniProtKB=T1FQJ3 T1FQJ3 20211090 PTHR46896:SF3 SENTRIN-SPECIFIC PROTEASE FI06413P-RELATED cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG72148|UniProtKB=T1G0W5 T1G0W5 20214713 PTHR12416:SF2 RRNA-PROCESSING PROTEIN UTP23 HOMOLOG RRNA-PROCESSING PROTEIN FCF1 HOMOLOG membrane-enclosed lumen#GO:0031974;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981 HELRO|EnsemblGenome=HelroG87546|UniProtKB=T1G6R9 T1G6R9 20216766 PTHR24082:SF283 NUCLEAR HORMONE RECEPTOR NUCLEAR HORMONE RECEPTOR HR96 cis-regulatory region sequence-specific DNA binding#GO:0000987;signaling receptor activity#GO:0038023;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of RNA metabolic process#GO:0051253;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of transcription by RNA polymerase II#GO:0000122;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;cellular developmental process#GO:0048869;negative regulation of biosynthetic process#GO:0009890;regulation of DNA-templated transcription#GO:0006355;negative regulation of metabolic process#GO:0009892;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;negative regulation of nitrogen compound metabolic process#GO:0051172;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG81623|UniProtKB=T1G4G7 T1G4G7 20215965 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG181251|UniProtKB=T1FGS8 T1FGS8 20208027 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG87141|UniProtKB=T1G6M2 T1G6M2 20216719 PTHR10634:SF67 AN1-TYPE ZINC FINGER PROTEIN AN1-TYPE ZINC FINGER PROTEIN 3 HELRO|EnsemblGenome=HelroG184401|UniProtKB=T1FL46 T1FL46 20209545 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG82780|UniProtKB=T1G4W4 T1G4W4 20216112 PTHR18945:SF784 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 1 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;localization#GO:0051179;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 membrane protein complex#GO:0098796;synapse#GO:0045202;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron projection#GO:0043005;transmembrane transporter complex#GO:1902495;cell projection#GO:0042995;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 Nicotinic acetylcholine receptor signaling pathway#P00044>beta#P01095;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HELRO|EnsemblGenome=HelroG76627|UniProtKB=T1G2M3 T1G2M3 20215321 PTHR11216:SF1 EH DOMAIN SARCALUMENIN localization#GO:0051179;endosomal transport#GO:0016197;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;endocytosis#GO:0006897;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;cellular process#GO:0009987;import into cell#GO:0098657 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG92354|UniProtKB=T1G8E9 T1G8E9 20217346 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG85573|UniProtKB=T1G5Z9 T1G5Z9 20216496 PTHR11995:SF14 NADH DEHYDROGENASE NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;electron transfer activity#GO:0009055;catalytic activity#GO:0003824;NADH dehydrogenase activity#GO:0003954;oxidoreductase activity, acting on NAD(P)H#GO:0016651;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804;oxidoreductase activity#GO:0016491 aerobic respiration#GO:0009060;cellular respiration#GO:0045333;transmembrane transport#GO:0055085;proton transmembrane transport#GO:1902600;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;energy derivation by oxidation of organic compounds#GO:0015980;localization#GO:0051179;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;metabolic process#GO:0008152 respirasome#GO:0070469;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;oxidoreductase complex#GO:1990204;respiratory chain complex I#GO:0045271;cellular anatomical entity#GO:0110165;membrane#GO:0016020;NADH dehydrogenase complex#GO:0030964 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG76182|UniProtKB=T1G2G3 T1G2G3 20215261 PTHR20902:SF0 41-2 PROTEIN ANTIGEN-RELATED TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5 localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193 endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle tethering complex#GO:0099023;TRAPP complex#GO:0030008;Golgi apparatus#GO:0005794;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793 HELRO|EnsemblGenome=HelroG78061|UniProtKB=T1G373 T1G373 20215521 PTHR13710:SF152 DNA HELICASE RECQ FAMILY MEMBER ATP-DEPENDENT DNA HELICASE Q5 ATP-dependent activity, acting on DNA#GO:0008094;3'-5' DNA helicase activity#GO:0043138;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;double-strand break repair#GO:0006302;nucleobase-containing compound metabolic process#GO:0006139;DNA geometric change#GO:0032392;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;recombinational repair#GO:0000725;DNA duplex unwinding#GO:0032508;DNA-templated DNA replication#GO:0006261;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;DNA unwinding involved in DNA replication#GO:0006268;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;double-strand break repair via homologous recombination#GO:0000724;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;DNA conformation change#GO:0071103;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;organelle organization#GO:0006996;chromosome organization#GO:0051276;cellular response to stress#GO:0033554;DNA replication#GO:0006260;DNA metabolic process#GO:0006259 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA helicase#PC00011;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG76370|UniProtKB=T1G2J1 T1G2J1 20215289 PTHR31214:SF3 PROTEIN FAM221A-RELATED PROTEIN FAM221B HELRO|EnsemblGenome=HelroG109931|UniProtKB=T1EEX4 T1EEX4 20195126 PTHR12608:SF1 TRANSMEMBRANE PROTEIN HTP-1 RELATED TRANSMEMBRANE PROTEIN 165 inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;inorganic cation transmembrane transporter activity#GO:0022890;metal ion transmembrane transporter activity#GO:0046873 HELRO|EnsemblGenome=HelroG96941|UniProtKB=T1G9E5 T1G9E5 20217692 PTHR11807:SF12 ATPASES OF THE PP SUPERFAMILY-RELATED CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1 tRNA binding#GO:0000049;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;tRNA wobble uridine modification#GO:0002098;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cytosol#GO:0005829;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG68327|UniProtKB=T1FZD0 T1FZD0 20214178 PTHR11324:SF1 IL16-RELATED PDZ DOMAIN-CONTAINING PROTEIN cytokine#PC00083;interleukin superfamily#PC00128 HELRO|EnsemblGenome=HelroG115835|UniProtKB=T1EGB1 T1EGB1 20195613 PTHR10174:SF130 ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED ALPHA-TOCOPHEROL TRANSFER PROTEIN-LIKE phosphatidylinositol bisphosphate binding#GO:1902936;lipid binding#GO:0008289;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981;binding#GO:0005488 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG181956|UniProtKB=T1FHI4 T1FHI4 20208283 PTHR46927:SF3 AGAP005574-PA THAP-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG131704|UniProtKB=T1EHW3 T1EHW3 20196163 PTHR12560:SF0 LONGEVITY ASSURANCE FACTOR 1 LAG1 LD18904P transferase activity#GO:0016740;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;N-acyltransferase activity#GO:0016410 lipid metabolic process#GO:0006629;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;membrane lipid biosynthetic process#GO:0046467;sphingolipid metabolic process#GO:0006665;ceramide metabolic process#GO:0006672;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;membrane lipid metabolic process#GO:0006643;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;ceramide biosynthetic process#GO:0046513;cellular lipid metabolic process#GO:0044255;amide metabolic process#GO:0043603;sphingolipid biosynthetic process#GO:0030148;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG174596|UniProtKB=T1F8A4 T1F8A4 20205053 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG185863|UniProtKB=T1FND3 T1FND3 20210330 PTHR12849:SF0 RNA LARIAT DEBRANCHING ENZYME LARIAT DEBRANCHING ENZYME catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG79668|UniProtKB=T1G3R9 T1G3R9 20215717 PTHR11566:SF212 DYNAMIN DYNAMIN GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;microtubule binding#GO:0008017;ribonucleoside triphosphate phosphatase activity#GO:0017111 localization#GO:0051179;establishment of localization#GO:0051234;receptor internalization#GO:0031623;transport#GO:0006810;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;receptor-mediated endocytosis#GO:0006898;cellular process#GO:0009987;import into cell#GO:0098657 supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cell periphery#GO:0071944;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cytoskeleton#GO:0005856;microtubule#GO:0005874;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG89725|UniProtKB=T1G7G6 T1G7G6 20217013 PTHR11467:SF36 HISTONE H1 HISTONE 24-RELATED nucleosome binding#GO:0031491;nucleic acid binding#GO:0003676;chromatin DNA binding#GO:0031490;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;protein-containing complex binding#GO:0044877 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA metabolic process#GO:0051052;chromosome condensation#GO:0030261;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;cellular process#GO:0009987;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;regulation of macromolecule metabolic process#GO:0060255;organelle organization#GO:0006996;chromosome organization#GO:0051276;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA recombination#GO:0045910;negative regulation of DNA metabolic process#GO:0051053;regulation of DNA recombination#GO:0000018;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG145048|UniProtKB=T1EJI2 T1EJI2 20196732 PTHR10071:SF281 TRANSCRIPTION FACTOR GATA FAMILY MEMBER BOX A-BINDING FACTOR-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of RNA metabolic process#GO:0051253;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of transcription by RNA polymerase II#GO:0000122;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;regulation of DNA-templated transcription#GO:0006355;negative regulation of metabolic process#GO:0009892;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;negative regulation of nitrogen compound metabolic process#GO:0051172;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG162786|UniProtKB=T1ET53 T1ET53 20199753 PTHR12107:SF0 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT STARGAZIN (MAMMALIAN CALCIUM CHANNEL) HOMOLOG calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;voltage-gated channel activity#GO:0022832;molecular function regulator activity#GO:0098772;transporter regulator activity#GO:0141108;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;channel regulator activity#GO:0016247;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;inorganic cation transmembrane transporter activity#GO:0022890 cellular localization#GO:0051641;macromolecule localization#GO:0033036;receptor internalization#GO:0031623;system process#GO:0003008;transport#GO:0006810;regulation of signaling#GO:0023051;nitrogen compound transport#GO:0071705;regulation of localization#GO:0032879;endosome to lysosome transport#GO:0008333;lysosomal transport#GO:0007041;establishment of protein localization#GO:0045184;regulation of biological process#GO:0050789;organic substance transport#GO:0071702;regulation of transport#GO:0051049;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;regulation of molecular function#GO:0065009;regulation of signal transduction#GO:0009966;receptor-mediated endocytosis#GO:0006898;regulation of monoatomic ion transmembrane transporter activity#GO:0032412;regulation of transmembrane transporter activity#GO:0022898;protein localization to organelle#GO:0033365;regulation of transporter activity#GO:0032409;positive regulation of signaling#GO:0023056;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;positive regulation of biological process#GO:0048518;localization within membrane#GO:0051668;regulation of cell communication#GO:0010646;establishment of protein localization to vacuole#GO:0072666;regulation of transmembrane transport#GO:0034762;vacuolar transport#GO:0007034;endocytosis#GO:0006897;protein localization to vacuole#GO:0072665;vesicle-mediated transport#GO:0016192;establishment of protein localization to organelle#GO:0072594;nervous system process#GO:0050877;cell communication#GO:0007154;cellular process#GO:0009987;regulation of synaptic transmission, glutamatergic#GO:0051966;protein localization#GO:0008104;positive regulation of cellular process#GO:0048522;localization#GO:0051179;regulation of response to stimulus#GO:0048583;protein localization to lysosome#GO:0061462;cellular macromolecule localization#GO:0070727;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;positive regulation of cell communication#GO:0010647;protein transport#GO:0015031;biological regulation#GO:0065007;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;regulation of trans-synaptic signaling#GO:0099177;multicellular organismal process#GO:0032501;intracellular transport#GO:0046907;positive regulation of synaptic transmission#GO:0050806;import into cell#GO:0098657;protein-containing complex localization#GO:0031503 membrane protein complex#GO:0098796;synapse#GO:0045202;postsynaptic specialization#GO:0099572;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;plasma membrane signaling receptor complex#GO:0098802;transporter complex#GO:1990351;plasma membrane protein complex#GO:0098797;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;neuron to neuron synapse#GO:0098984;membrane#GO:0016020;synaptic membrane#GO:0097060;asymmetric synapse#GO:0032279;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;transmembrane transporter complex#GO:1902495;postsynaptic density membrane#GO:0098839;postsynaptic specialization membrane#GO:0099634;plasma membrane region#GO:0098590;postsynapse#GO:0098794;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG189694|UniProtKB=T1FR95 T1FR95 20211342 PTHR23320:SF173 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MARVEL DOMAIN-CONTAINING PROTEIN-RELATED transporter#PC00227 HELRO|EnsemblGenome=HelroG74964|UniProtKB=T1G1Y7 T1G1Y7 20215085 PTHR19384:SF10 NITRIC OXIDE SYNTHASE-RELATED NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1 carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;flavin adenine dinucleotide binding#GO:0050660;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;oxidoreductase activity#GO:0016491 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG162619|UniProtKB=T1ESX5 T1ESX5 20199675 PTHR34441:SF1 MOTILE SPERM DOMAIN-CONTAINING PROTEIN 1 MOTILE SPERM DOMAIN-CONTAINING 1 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG184809|UniProtKB=T1FM14 T1FM14 20209863 PTHR46076:SF3 E3 UBIQUITIN-PROTEIN LIGASE RING1 / RING 2 FAMILY MEMBER E3 UBIQUITIN-PROTEIN LIGASE RING1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;binding#GO:0005488;catalytic activity#GO:0003824;chromatin binding#GO:0003682;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;protein-containing complex binding#GO:0044877;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 PcG protein complex#GO:0031519;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG104849|UniProtKB=T1EDN8 T1EDN8 20194690 PTHR24247:SF241 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE RECEPTOR 2A-RELATED signaling receptor activity#GO:0038023;G protein-coupled amine receptor activity#GO:0008227;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission#GO:0007268;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;synaptic signaling#GO:0099536;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;cell-cell signaling#GO:0007267 somatodendritic compartment#GO:0036477;neuron projection#GO:0043005;dendrite#GO:0030425;cell periphery#GO:0071944;dendritic tree#GO:0097447;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 5HT2 type receptor mediated signaling pathway#P04374>5HT2 Receptor#P04414;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720 HELRO|EnsemblGenome=HelroG181788|UniProtKB=T1FHB8 T1FHB8 20208217 PTHR34491:SF156 A-TYPE INCLUSION PROTEIN, PUTATIVE-RELATED KINESIN MOTOR DOMAIN-CONTAINING PROTEIN Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG162828|UniProtKB=T1ET83 T1ET83 20199783 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG156659|UniProtKB=T1ELZ6 T1ELZ6 20197596 PTHR11592:SF78 GLUTATHIONE PEROXIDASE GLUTATHIONE PEROXIDASE peroxidase#PC00180;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG193539|UniProtKB=T1FV38 T1FV38 20212684 PTHR24103:SF557 E3 UBIQUITIN-PROTEIN LIGASE TRIM RING-TYPE DOMAIN-CONTAINING PROTEIN ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG110329|UniProtKB=T1EF15 T1EF15 20195167 PTHR20939:SF11 SORTING NEXIN 20, 21 LD12265P lipid binding#GO:0008289;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981;binding#GO:0005488 bounding membrane of organelle#GO:0098588;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;early endosome#GO:0005769;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;vesicle membrane#GO:0012506;organelle#GO:0043226;membrane#GO:0016020;endosome membrane#GO:0010008;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;early endosome membrane#GO:0031901;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cytoplasmic vesicle membrane#GO:0030659 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185081|UniProtKB=T1FMD4 T1FMD4 20209983 PTHR12277:SF81 ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN PROTEIN ABHD13 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG81998|UniProtKB=T1G4L5 T1G4L5 20216013 PTHR12143:SF19 PEPTIDE N-GLYCANASE PNGASE -RELATED PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824 carbohydrate derivative metabolic process#GO:1901135;macromolecule catabolic process#GO:0009057;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;carbohydrate derivative catabolic process#GO:1901136;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycoprotein metabolic process#GO:0009100 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 hydrolase#PC00121 Oxidative stress response#P00046>TRX#P01122;Hypoxia response via HIF activation#P00030>Thioredoxin#P00825 HELRO|EnsemblGenome=HelroG185936|UniProtKB=T1FNG6 T1FNG6 20210363 PTHR19868:SF0 RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1 SMALL RIBOSOMAL SUBUNIT PROTEIN RACK1 binding#GO:0005488;ribonucleoprotein complex binding#GO:0043021;ribosome binding#GO:0043022;protein binding#GO:0005515;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;protein-containing complex binding#GO:0044877;kinase binding#GO:0019900 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;regulation of nitrogen compound metabolic process#GO:0051171;peptide metabolic process#GO:0006518;positive regulation of cellular metabolic process#GO:0031325;gene expression#GO:0010467;biosynthetic process#GO:0009058;positive regulation of protein modification process#GO:0031401;translation#GO:0006412;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;cellular component disassembly#GO:0022411;positive regulation of metabolic process#GO:0009893;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;positive regulation of biological process#GO:0048518;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;positive regulation of protein phosphorylation#GO:0001934;positive regulation of phosphorylation#GO:0042327;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;positive regulation of phosphorus metabolic process#GO:0010562;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;organelle disassembly#GO:1903008;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;amide biosynthetic process#GO:0043604;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;positive regulation of protein metabolic process#GO:0051247;peptide biosynthetic process#GO:0043043;positive regulation of phosphate metabolic process#GO:0045937;regulation of macromolecule metabolic process#GO:0060255;organelle organization#GO:0006996;regulation of protein phosphorylation#GO:0001932;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;translational elongation#GO:0006414;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG168146|UniProtKB=T1F080 T1F080 20202230 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157926|UniProtKB=T1EMH8 T1EMH8 20197778 PTHR10371:SF3 NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL NADH dehydrogenase activity#GO:0003954;oxidoreductase activity, acting on NAD(P)H#GO:0016651;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 dehydrogenase#PC00092;oxidoreductase#PC00176 Parkinson disease#P00049>Complex I#P01237 HELRO|EnsemblGenome=HelroG181103|UniProtKB=T1FGL9 T1FGL9 20207968 PTHR23179:SF3 T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED RHO GTPASE-ACTIVATING PROTEIN 20 nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;GTPase regulator activity#GO:0030695;molecular function activator activity#GO:0140677;GTPase activator activity#GO:0005096;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG185969|UniProtKB=T1FNH9 T1FNH9 20210376 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;chloride transmembrane transporter activity#GO:0015108;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;inorganic anion transmembrane transport#GO:0098661;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic anion transport#GO:0006820;chloride transport#GO:0006821;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;inorganic anion transport#GO:0015698 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG72614|UniProtKB=T1G125 T1G125 20214773 PTHR24637:SF377 COLLAGEN COLLAGEN TYPE IX ALPHA 1 CHAIN HELRO|EnsemblGenome=HelroG80604|UniProtKB=T1G427 T1G427 20215825 PTHR11177:SF317 CHITINASE CHITINASE 12-RELATED glycosidase#PC00110;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG189312|UniProtKB=T1FQY1 T1FQY1 20211228 PTHR13388:SF11 DETONATOR, ISOFORM E DETONATOR, ISOFORM E HELRO|EnsemblGenome=HelroG95167|UniProtKB=T1G947 T1G947 20217594 PTHR24205:SF4 FOUR AND A HALF LIM DOMAINS PROTEIN PROTEIN ESPINAS molecular adaptor activity#GO:0060090;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;protein-macromolecule adaptor activity#GO:0030674 supramolecular complex#GO:0099080;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;Z disc#GO:0030018;cellular anatomical entity#GO:0110165;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;contractile fiber#GO:0043292;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;sarcomere#GO:0030017;membrane-bounded organelle#GO:0043227;myofibril#GO:0030016;I band#GO:0031674 transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG173292|UniProtKB=T1F6N2 T1F6N2 20204481 PTHR31786:SF2 FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 24 FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 24 protein-containing complex binding#GO:0044877;chromatin binding#GO:0003682;binding#GO:0005488 protein-containing complex#GO:0032991;Fanconi anaemia nuclear complex#GO:0043240;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG173964|UniProtKB=T1F7F3 T1F7F3 20204752 PTHR12307:SF36 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT GLYCOGEN-BINDING SUBUNIT 76A phosphatase binding#GO:0019902;enzyme binding#GO:0019899;protein binding#GO:0005515;protein phosphatase binding#GO:0019903;binding#GO:0005488 protein serine/threonine phosphatase complex#GO:0008287;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical entity#GO:0110165;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG129966|UniProtKB=T1EHS8 T1EHS8 20196128 PTHR43671:SF105 SERINE/THREONINE-PROTEIN KINASE NEK PROTEIN KINASE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG177811|UniProtKB=T1FCA9 T1FCA9 20206458 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG190145|UniProtKB=T1FRQ6 T1FRQ6 20211503 PTHR14689:SF0 PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN COILED-COIL DOMAIN-CONTAINING PROTEIN 82 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG178482|UniProtKB=T1FD88 T1FD88 20206787 PTHR46123:SF4 MIX-TYPE HOMEOBOX GENE 1-RELATED MIX-TYPE HOMEOBOX GENE 1-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG155902|UniProtKB=T1ELP0 T1ELP0 20197490 PTHR12111:SF2 SPLICING FACTOR YJU2 SPLICING FACTOR YJU2B-RELATED cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;U2-type spliceosomal complex#GO:0005684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;post-mRNA release spliceosomal complex#GO:0071014;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG62073|UniProtKB=T1FWV3 T1FWV3 20213301 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG179754|UniProtKB=T1FF44 T1FF44 20207443 PTHR18842:SF2 INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1-BINDING PROTEIN 1 INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1-BINDING PROTEIN 1 HELRO|EnsemblGenome=HelroG81736|UniProtKB=T1G4I1 T1G4I1 20215979 PTHR21490:SF0 ENKURIN-RELATED ENKURIN protein binding#GO:0005515;calmodulin binding#GO:0005516;binding#GO:0005488 HELRO|EnsemblGenome=HelroG186143|UniProtKB=T1FNQ3 T1FNQ3 20210450 PTHR11588:SF429 TUBULIN TUBULIN BETA 8B-RELATED carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;structural molecule activity#GO:0005198;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;structural constituent of cytoskeleton#GO:0005200 cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;microtubule-based process#GO:0007017;organelle organization#GO:0006996;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;cell cycle#GO:0007049;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 tubulin#PC00228;microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Microtubule#P00780;Huntington disease#P00029>beta-Tubulin#P00790;Cytoskeletal regulation by Rho GTPase#P00016>tubulin#P00526 HELRO|EnsemblGenome=HelroG131517|UniProtKB=T1EHW0 T1EHW0 20196160 PTHR14340:SF9 MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3 FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194502|UniProtKB=T1FW47 T1FW47 20213043 PTHR19282:SF452 TETRASPANIN LD03691P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG82003|UniProtKB=T1G4L6 T1G4L6 20216014 PTHR14499:SF136 POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING GH08630P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG92341|UniProtKB=T1G8E6 T1G8E6 20217343 PTHR23512:SF5 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG175519|UniProtKB=T1F9C6 T1F9C6 20205425 PTHR30060:SF0 INNER MEMBRANE PROTEIN COILED-COIL PROTEIN (DUF2040)-RELATED HELRO|EnsemblGenome=HelroG171534|UniProtKB=T1F4E0 T1F4E0 20203689 PTHR48169:SF7 DED DOMAIN-CONTAINING PROTEIN CASPASE 10 HELRO|EnsemblGenome=HelroG87238|UniProtKB=T1G6N3 T1G6N3 20216730 PTHR10127:SF861 DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING DORSAL-VENTRAL PATTERNING PROTEIN TOLLOID-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 SCW signaling pathway#P06216>TLD#P06327;DPP-SCW signaling pathway#P06212>TLD#P06264;TGF-beta signaling pathway#P00052>TGFbeta#P01286;DPP signaling pathway#P06213>TLD#P06283;BMP/activin signaling pathway-drosophila#P06211>TLD#P06249 HELRO|EnsemblGenome=HelroG94516|UniProtKB=T1G916 T1G916 20217563 PTHR10894:SF1 NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58 NUCLEOLAR PROTEIN 58 snoRNA binding#GO:0030515;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 small-subunit processome#GO:0032040;ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;protein-containing complex#GO:0032991;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG192780|UniProtKB=T1FUA0 T1FUA0 20212396 PTHR39490:SF13 ARRESTIN DOMAIN-CONTAINING PROTEIN D FYVE-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG160565|UniProtKB=T1EQF3 T1EQF3 20198803 PTHR10694:SF33 LYSINE-SPECIFIC DEMETHYLASE LYSINE-SPECIFIC DEMETHYLASE 5 histone modifying activity#GO:0140993;demethylase activity#GO:0032451;catalytic activity, acting on a protein#GO:0140096;histone demethylase activity#GO:0032452;catalytic activity#GO:0003824 protein-DNA complex organization#GO:0071824;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;protein-containing complex organization#GO:0043933;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG170509|UniProtKB=T1F353 T1F353 20203252 PTHR24026:SF126 FAT ATYPICAL CADHERIN-RELATED PROTOCADHERIN FAT 4 cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HELRO|EnsemblGenome=HelroG194192|UniProtKB=T1FVS4 T1FVS4 20212920 PTHR45828:SF9 CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE CELL WALL INTEGRITY AND STRESS RESPONSE COMPONENT 4-LIKE-RELATED cellular anatomical entity#GO:0110165;membrane#GO:0016020 reductase#PC00198;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG151951|UniProtKB=T1EKN3 T1EKN3 20197133 PTHR36975:SF6 FAMILY NOT NAMED HISTIDINE-RICH GLYCOPROTEIN-LIKE HELRO|EnsemblGenome=HelroG163054|UniProtKB=T1ETL9 T1ETL9 20199919 PTHR23092:SF15 POLY(A) RNA POLYMERASE INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED adenylyltransferase activity#GO:0070566;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;transferase activity#GO:0016740;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772;mRNA binding#GO:0003729 cellular aromatic compound metabolic process#GO:0006725;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;modification-dependent macromolecule catabolic process#GO:0043632;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;organic substance catabolic process#GO:1901575;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;macromolecule biosynthetic process#GO:0009059;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;polyadenylation-dependent ncRNA catabolic process#GO:0043634 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG91636|UniProtKB=T1G868 T1G868 20217265 PTHR11920:SF494 GUANYLYL CYCLASE ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2 adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 Gonadotropin-releasing hormone receptor pathway#P06664>Npr2#P06796;Endothelin signaling pathway#P00019>Guanylate cyclase#P00581 HELRO|EnsemblGenome=HelroG180468|UniProtKB=T1FFY7 T1FFY7 20207736 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED FMRFAMIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG147263|UniProtKB=T1EJY8 T1EJY8 20196888 PTHR11058:SF9 NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3 NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3 transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;electron transfer activity#GO:0009055;catalytic activity#GO:0003824;oxidoreductase activity, acting on NAD(P)H#GO:0016651;NADH dehydrogenase activity#GO:0003954;active transmembrane transporter activity#GO:0022804;oxidoreductase activity#GO:0016491;transporter activity#GO:0005215 oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;membrane#GO:0016020;NADH dehydrogenase complex#GO:0030964;catalytic complex#GO:1902494 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG79022|UniProtKB=T1G3I6 T1G3I6 20215634 PTHR23113:SF224 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1 nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;Ras protein signal transduction#GO:0007265;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 Integrin signalling pathway#P00034>C3G#P00929 HELRO|EnsemblGenome=HelroG189442|UniProtKB=T1FR23 T1FR23 20211270 PTHR23294:SF0 ET TRANSLATION PRODUCT-RELATED UNC93-LIKE PROTEIN MFSD11 HELRO|EnsemblGenome=HelroG62550|UniProtKB=T1FX22 T1FX22 20213370 PTHR12484:SF4 B-LYMPHOCYTE ANTIGEN-RELATED A-KINASE ANCHOR PROTEIN 17A HELRO|EnsemblGenome=HelroG107709|UniProtKB=T1EEC4 T1EEC4 20194926 PTHR10026:SF144 CYCLIN CYCLIN-K protein kinase activator activity#GO:0030295;protein kinase regulator activity#GO:0019887;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;kinase regulator activity#GO:0019207;kinase activator activity#GO:0019209 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of DNA-templated transcription, elongation#GO:0032786;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;regulation of DNA-templated transcription elongation#GO:0032784;regulation of DNA-templated transcription#GO:0006355;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;transcription elongation factor complex#GO:0008023;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 kinase activator#PC00138 Cell cycle#P00013>CdkC#P00489 HELRO|EnsemblGenome=HelroG81228|UniProtKB=T1G4B8 T1G4B8 20215916 PTHR24082:SF473 NUCLEAR HORMONE RECEPTOR ECDYSONE-INDUCED PROTEIN 75B, ISOFORM B cis-regulatory region sequence-specific DNA binding#GO:0000987;signaling receptor activity#GO:0038023;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;signal transduction#GO:0007165;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of RNA metabolic process#GO:0051253;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;hormone-mediated signaling pathway#GO:0009755;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;positive regulation of biosynthetic process#GO:0009891;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of transcription by RNA polymerase II#GO:0000122;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;response to organic substance#GO:0010033;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;cellular response to endogenous stimulus#GO:0071495;negative regulation of biosynthetic process#GO:0009890;cellular response to chemical stimulus#GO:0070887;regulation of DNA-templated transcription#GO:0006355;cellular response to organic substance#GO:0071310;negative regulation of metabolic process#GO:0009892;cell communication#GO:0007154;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;negative regulation of nitrogen compound metabolic process#GO:0051172;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;negative regulation of macromolecule biosynthetic process#GO:0010558;response to hormone#GO:0009725;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;response to chemical#GO:0042221;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG97768|UniProtKB=T1G9I9 T1G9I9 20217736 PTHR12360:SF1 NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1 NF-X1-TYPE ZINC FINGER PROTEIN NFXL1 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG89194|UniProtKB=T1G7A0 T1G7A0 20216947 PTHR10509:SF93 O-METHYLTRANSFERASE-RELATED CATECHOL O-METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1 methyltransferase activity#GO:0008168;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757 methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG177867|UniProtKB=T1FCE1 T1FCE1 20206490 PTHR12242:SF45 OS02G0130600 PROTEIN-RELATED MARVEL DOMAIN-CONTAINING PROTEIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG65417|UniProtKB=T1FY75 T1FY75 20213773 PTHR11662:SF455 SOLUTE CARRIER FAMILY 17 GH23975P transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810;monoatomic anion transport#GO:0006820 cellular anatomical entity#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG92485|UniProtKB=T1G8H3 T1G8H3 20217370 PTHR45771:SF6 HOMEOTIC PROTEIN DEFORMED HOMEOTIC PROTEIN SEX COMBS REDUCED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;pattern specification process#GO:0007389;positive regulation of biological process#GO:0048518;regulation of DNA-templated transcription#GO:0006355;multicellular organism development#GO:0007275;regionalization#GO:0003002;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;anatomical structure development#GO:0048856;biological regulation#GO:0065007;anterior/posterior pattern specification#GO:0009952;multicellular organismal process#GO:0032501;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG82145|UniProtKB=T1G4N6 T1G4N6 20216034 PTHR11477:SF0 TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN IP08861P-RELATED cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG176931|UniProtKB=T1FB20 T1FB20 20206019 PTHR10027:SF10 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN SLOWPOKE 2, ISOFORM D monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;potassium ion transmembrane transporter activity#GO:0015079;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG181690|UniProtKB=T1FH86 T1FH86 20208185 PTHR31654:SF0 SECRETED BETA-GLUCOSIDASE ADG3-RELATED SECRETED BETA-GLUCOSIDASE ADG3-RELATED glucosidase#PC00108 HELRO|EnsemblGenome=HelroG182049|UniProtKB=T1FHN3 T1FHN3 20208332 PTHR19282:SF431 TETRASPANIN TETRASPANIN 26A, ISOFORM B-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG72508|UniProtKB=T1G110 T1G110 20214758 PTHR19300:SF57 BETA-1,4-GALACTOSYLTRANSFERASE BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE galactosyltransferase activity#GO:0008378;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycosylation#GO:0070085;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG161499|UniProtKB=T1ERK0 T1ERK0 20199200 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG155577|UniProtKB=T1ELJ0 T1ELJ0 20197440 PTHR45703:SF8 DYNEIN HEAVY CHAIN DYNEINS HEAVY CHAIN microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG80718|UniProtKB=T1G443 T1G443 20215841 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED single-stranded RNA binding#GO:0003727;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;poly(A) binding#GO:0008143;binding#GO:0005488;organic cyclic compound binding#GO:0097159 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG171891|UniProtKB=T1F4T1 T1F4T1 20203830 PTHR33395:SF21 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED PERICARDIN heart morphogenesis#GO:0003007;system development#GO:0048731;heart development#GO:0007507;circulatory system development#GO:0072359;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;animal organ development#GO:0048513;multicellular organism development#GO:0007275;developmental process#GO:0032502;animal organ morphogenesis#GO:0009887;multicellular organismal process#GO:0032501;cell adhesion#GO:0007155;cellular process#GO:0009987;post-embryonic development#GO:0009791 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG65381|UniProtKB=T1FY69 T1FY69 20213767 PTHR10336:SF196 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN PHOSPHOINOSITIDE PHOSPHOLIPASE C hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phospholipase C activity#GO:0004629;phospholipase activity#GO:0004620;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578 lipid metabolic process#GO:0006629;signal transduction#GO:0007165;negative regulation of biological process#GO:0048519;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of sequestering of calcium ion#GO:0051282;regulation of signaling#GO:0023051;regulation of localization#GO:0032879;inorganic ion transmembrane transport#GO:0098660;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;calcium ion transport#GO:0006816;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;glycerolipid metabolic process#GO:0046486;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;intracellular signal transduction#GO:0035556;cell-cell signaling#GO:0007267;signaling#GO:0023052;negative regulation of cellular process#GO:0048523;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;regulation of cell communication#GO:0010646;cellular response to stimulus#GO:0051716;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;cellular metabolic process#GO:0044237;release of sequestered calcium ion into cytosol#GO:0051209;cell communication#GO:0007154;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;cellular process#GO:0009987;primary metabolic process#GO:0044238;localization#GO:0051179;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;monoatomic ion transmembrane transport#GO:0034220;calcium ion transmembrane import into cytosol#GO:0097553;biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177;organophosphate metabolic process#GO:0019637;monoatomic ion transport#GO:0006811;cellular lipid metabolic process#GO:0044255;negative regulation of sequestering of calcium ion#GO:0051283;monoatomic cation transmembrane transport#GO:0098655 phospholipase#PC00186 Oxytocin receptor mediated signaling pathway#P04391>PLC beta#P04530;5HT2 type receptor mediated signaling pathway#P04374>PLC#P04412;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PLC#P04581 HELRO|EnsemblGenome=HelroG108199|UniProtKB=T1EEG7 T1EEG7 20194969 PTHR13254:SF0 GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7 GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN cellular localization#GO:0051641;macromolecule localization#GO:0033036;macromolecule modification#GO:0043412;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;protein palmitoylation#GO:0018345;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;localization within membrane#GO:0051668;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein localization to membrane#GO:0072657;organonitrogen compound biosynthetic process#GO:1901566;protein targeting#GO:0006605;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;protein acylation#GO:0043543;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipoprotein biosynthetic process#GO:0042158;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;lipoprotein metabolic process#GO:0042157 protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234 HELRO|EnsemblGenome=HelroG175082|UniProtKB=T1F8U0 T1F8U0 20205239 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166577|UniProtKB=T1EY97 T1EY97 20201547 PTHR45961:SF6 IP21249P IP21249P Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG117076|UniProtKB=T1EGK0 T1EGK0 20195701 PTHR12474:SF0 P53 REGULATED PA26 NUCLEAR PROTEIN SESTRIN SESTRIN HOMOLOG amino acid binding#GO:0016597;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;carboxylic acid binding#GO:0031406;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;organic acid binding#GO:0043177;anion binding#GO:0043168;ion binding#GO:0043167;oxidoreductase activity#GO:0016491 negative regulation of biological process#GO:0048519;regulation of catabolic process#GO:0009894;negative regulation of intracellular signal transduction#GO:1902532;positive regulation of cellular metabolic process#GO:0031325;regulation of signaling#GO:0023051;positive regulation of cellular catabolic process#GO:0031331;response to extracellular stimulus#GO:0009991;regulation of intracellular signal transduction#GO:1902531;cellular response to nitrogen compound#GO:1901699;negative regulation of TOR signaling#GO:0032007;regulation of biological process#GO:0050789;cellular response to oxygen-containing compound#GO:1901701;response to endogenous stimulus#GO:0009719;cellular response to starvation#GO:0009267;positive regulation of metabolic process#GO:0009893;regulation of signal transduction#GO:0009966;positive regulation of biological process#GO:0048518;negative regulation of cell communication#GO:0010648;negative regulation of cellular process#GO:0048523;cellular response to extracellular stimulus#GO:0031668;response to organic substance#GO:0010033;regulation of cell communication#GO:0010646;cellular response to stimulus#GO:0051716;regulation of TORC1 signaling#GO:1903432;cellular response to endogenous stimulus#GO:0071495;negative regulation of response to stimulus#GO:0048585;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;cellular response to organic substance#GO:0071310;regulation of autophagy#GO:0010506;negative regulation of signaling#GO:0023057;cell communication#GO:0007154;regulation of macroautophagy#GO:0016241;response to organonitrogen compound#GO:0010243;response to nutrient levels#GO:0031667;regulation of cellular catabolic process#GO:0031329;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to external stimulus#GO:0009605;response to stress#GO:0006950;positive regulation of macroautophagy#GO:0016239;response to chemical#GO:0042221;cellular response to nutrient levels#GO:0031669;cellular response to organonitrogen compound#GO:0071417;regulation of cellular process#GO:0050794;response to starvation#GO:0042594;biological regulation#GO:0065007;cellular response to external stimulus#GO:0071496;positive regulation of catabolic process#GO:0009896;negative regulation of signal transduction#GO:0009968;positive regulation of autophagy#GO:0010508;cellular response to amino acid starvation#GO:0034198;negative regulation of TORC1 signaling#GO:1904262;cellular response to stress#GO:0033554;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 peroxidase#PC00180;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG75246|UniProtKB=T1G229 T1G229 20215127 PTHR20383:SF9 RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE SSU72 hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;mRNA cleavage factor complex#GO:0005849;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG112333|UniProtKB=T1EFI8 T1EFI8 20195340 PTHR11098:SF1 NICOTINATE PHOSPHORIBOSYLTRANSFERASE NICOTINATE PHOSPHORIBOSYLTRANSFERASE ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;pyridine nucleotide metabolic process#GO:0019362;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;nucleotide biosynthetic process#GO:0009165;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;nicotinamide nucleotide metabolic process#GO:0046496;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG89777|UniProtKB=T1G7H5 T1G7H5 20217022 PTHR10182:SF3 CALCIUM-BINDING PROTEIN 39-RELATED PROTEIN MO25 protein kinase activator activity#GO:0030295;molecular function activator activity#GO:0140677;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234;kinase activator activity#GO:0019209 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 HELRO|EnsemblGenome=HelroG74564|UniProtKB=T1G1S8 T1G1S8 20215026 PTHR10625:SF23 HISTONE DEACETYLASE HDAC1-RELATED HISTONE DEACETYLASE 11 histone modifying activity#GO:0140993;histone deacetylase activity#GO:0004407;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;deacetylase activity#GO:0019213;catalytic activity, acting on a protein#GO:0140096 protein-DNA complex organization#GO:0071824;cellular component organization#GO:0016043;cellular process#GO:0009987;epigenetic regulation of gene expression#GO:0040029;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;protein-containing complex organization#GO:0043933;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;histone deacetylase complex#GO:0000118;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG181123|UniProtKB=T1FGM9 T1FGM9 20207978 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164062|UniProtKB=T1EUU9 T1EUU9 20200349 PTHR46880:SF5 RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG155703|UniProtKB=T1ELK9 T1ELK9 20197459 PTHR46472:SF1 NUCLEOREDOXIN NUCLEOREDOXIN protein-disulfide reductase activity#GO:0015035;disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;antioxidant activity#GO:0016209;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of protein modification process#GO:0031399;regulation of protein metabolic process#GO:0051246;negative regulation of response to stimulus#GO:0048585;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of protein modification process#GO:0031400;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of protein ubiquitination#GO:0031397;regulation of Wnt signaling pathway#GO:0030111;negative regulation of macromolecule metabolic process#GO:0010605;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of cellular process#GO:0048523;negative regulation of cell communication#GO:0010648;regulation of metabolic process#GO:0019222 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG188170|UniProtKB=T1FPQ3 T1FPQ3 20210800 PTHR11036:SF127 SEMAPHORIN SEMAPHORIN-1A molecular function activator activity#GO:0140677;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;protein binding#GO:0005515;signaling receptor binding#GO:0005102 cellular developmental process#GO:0048869;regulation of cell motility#GO:2000145;regulation of locomotion#GO:0040012;stem cell development#GO:0048864;animal organ development#GO:0048513;neural crest cell development#GO:0014032;developmental process#GO:0032502;positive regulation of locomotion#GO:0040017;ameboidal-type cell migration#GO:0001667;cell motility#GO:0048870;cellular process#GO:0009987;tissue development#GO:0009888;mesenchymal cell differentiation#GO:0048762;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;cell development#GO:0048468;cell differentiation#GO:0030154;regulation of cell migration#GO:0030334;positive regulation of cell migration#GO:0030335;neural crest cell differentiation#GO:0014033;regulation of cellular process#GO:0050794;mesenchyme development#GO:0060485;anatomical structure development#GO:0048856;positive regulation of cell motility#GO:2000147;biological regulation#GO:0065007;stem cell differentiation#GO:0048863;neural crest cell migration#GO:0001755;cell migration#GO:0016477;positive regulation of biological process#GO:0048518 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 membrane-bound signaling molecule#PC00152;intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG95885|UniProtKB=T1G986 T1G986 20217633 PTHR22990:SF20 F-BOX ONLY PROTEIN F-BOX ONLY PROTEIN 11 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;regulation of apoptotic process#GO:0042981;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;biological regulation#GO:0065007;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;regulation of programmed cell death#GO:0043067;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG171192|UniProtKB=T1F3X2 T1F3X2 20203521 PTHR44755:SF8 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide hormone binding#GO:0017046;hormone binding#GO:0042562;binding#GO:0005488;peptide binding#GO:0042277;amide binding#GO:0033218 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG192808|UniProtKB=T1FUB6 T1FUB6 20212412 PTHR14222:SF2 CONDENSIN CONDENSIN COMPLEX SUBUNIT 1 protein binding#GO:0005515;histone binding#GO:0042393;binding#GO:0005488 nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;meiotic cell cycle#GO:0051321;nuclear division#GO:0000280;cell cycle process#GO:0022402;chromosome condensation#GO:0030261;cellular component organization#GO:0016043;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047;mitotic chromosome condensation#GO:0007076;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;chromosome organization involved in meiotic cell cycle#GO:0070192;mitotic cell cycle#GO:0000278;reproduction#GO:0000003;organelle organization#GO:0006996;chromosome organization#GO:0051276;meiotic cell cycle process#GO:1903046;sexual reproduction#GO:0019953;reproductive process#GO:0022414;cell cycle#GO:0007049;mitotic nuclear division#GO:0140014;organelle fission#GO:0048285;mitotic sister chromatid segregation#GO:0000070 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;condensed chromosome, centromeric region#GO:0000779;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;chromosomal region#GO:0098687;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG82100|UniProtKB=T1G4M7 T1G4M7 20216025 PTHR24229:SF40 NEUROPEPTIDES RECEPTOR ALLATOSTATIN C RECEPTOR 1-RELATED G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HELRO|EnsemblGenome=HelroG191914|UniProtKB=T1FTE9 T1FTE9 20212096 PTHR24410:SF41 HL07962P-RELATED HL07962P defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG164811|UniProtKB=T1EVU3 T1EVU3 20200693 PTHR44170:SF54 PROTEIN SIDEKICK FI24025P1 cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG172057|UniProtKB=T1F4Z4 T1F4Z4 20203893 PTHR28336:SF3 BA1-643 CHROMOSOME 11 C6ORF62 HOMOLOG HELRO|EnsemblGenome=HelroG77906|UniProtKB=T1G353 T1G353 20215501 PTHR16110:SF1 TBC1 DOMAIN FAMILY MEMBER 19 TBC1 DOMAIN FAMILY MEMBER 19 HELRO|EnsemblGenome=HelroG177795|UniProtKB=T1FCA1 T1FCA1 20206450 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG189092|UniProtKB=T1FQM6 T1FQM6 20211123 PTHR46357:SF1 TRANSCRIPTIONAL REGULATOR ATRX TRANSCRIPTIONAL REGULATOR ATRX nucleic acid binding#GO:0003676;chromatin DNA binding#GO:0031490;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;methylated histone binding#GO:0035064;histone binding#GO:0042393;modification-dependent protein binding#GO:0140030 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;protein-DNA complex organization#GO:0071824;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;protein-containing complex organization#GO:0043933;nitrogen compound metabolic process#GO:0006807;DNA-templated DNA replication#GO:0006261;chromatin organization#GO:0006325;replication fork processing#GO:0031297;DNA replication#GO:0006260;chromatin remodeling#GO:0006338;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome, centromeric region#GO:0000775;heterochromatin#GO:0000792;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;chromosomal region#GO:0098687 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG173266|UniProtKB=T1F6M3 T1F6M3 20204472 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG173624|UniProtKB=T1F723 T1F723 20204622 PTHR14191:SF3 PDZ DOMAIN CONTAINING PROTEIN NA(+)_H(+) EXCHANGE REGULATORY COFACTOR-LIKE PROTEIN NRFL-1 protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 localization#GO:0051179;protein localization to plasma membrane#GO:0072659;protein localization to cell periphery#GO:1990778;localization within membrane#GO:0051668;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;cellular process#GO:0009987;protein localization#GO:0008104 plasma membrane region#GO:0098590;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;apical part of cell#GO:0045177;plasma membrane#GO:0005886;apical plasma membrane#GO:0016324 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG154236|UniProtKB=T1ELE1 T1ELE1 20197391 PTHR11079:SF156 CYTOSINE DEAMINASE FAMILY MEMBER INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;adenosine deaminase activity#GO:0004000;tRNA-specific adenosine deaminase activity#GO:0008251;deaminase activity#GO:0019239;catalytic activity#GO:0003824 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 deaminase#PC00088;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG91486|UniProtKB=T1G842 T1G842 20217239 PTHR48032:SF18 RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6 RRM DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG145643|UniProtKB=T1EJL5 T1EJL5 20196765 PTHR10281:SF106 MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED IP06960P-RELATED cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG194286|UniProtKB=T1FVW4 T1FVW4 20212960 PTHR24073:SF352 DRAB5-RELATED RAS-RELATED PROTEIN RAB6 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 endosomal transport#GO:0016197;cellular localization#GO:0051641;intra-Golgi vesicle-mediated transport#GO:0006891;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;cytosolic transport#GO:0016482;establishment of protein localization#GO:0045184;retrograde transport, endosome to Golgi#GO:0042147;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG86707|UniProtKB=T1G6F8 T1G6F8 20216655 PTHR24104:SF51 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG157857|UniProtKB=T1EMG9 T1EMG9 20197769 PTHR13183:SF0 AXONEMAL INNER ARM DYNEIN LIGHT CHAIN 28 AXONEMAL DYNEIN LIGHT INTERMEDIATE POLYPEPTIDE 1 protein binding#GO:0005515;binding#GO:0005488 axoneme#GO:0005930;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;plasma membrane bounded cell projection cytoplasm#GO:0032838;ciliary plasm#GO:0097014;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cytoskeleton#GO:0005856;cilium#GO:0005929 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG162934|UniProtKB=T1ETD7 T1ETD7 20199837 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG166054|UniProtKB=T1EXN1 T1EXN1 20201331 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cell communication#GO:0007154;cellular process#GO:0009987;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;Notch signaling pathway#GO:0007219 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG193046|UniProtKB=T1FUK2 T1FUK2 20212498 PTHR25462:SF305 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG177498|UniProtKB=T1FBT0 T1FBT0 20206279 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG79628|UniProtKB=T1G3R4 T1G3R4 20215712 PTHR10030:SF37 ALPHA-L-FUCOSIDASE ALPHA-L-FUCOSIDASE-RELATED hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 monosaccharide metabolic process#GO:0005996;carbohydrate derivative metabolic process#GO:1901135;glycosyl compound catabolic process#GO:1901658;carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;hexose metabolic process#GO:0019318;glycosyl compound metabolic process#GO:1901657;carbohydrate metabolic process#GO:0005975;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;lysosome#GO:0005764;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;vacuole#GO:0005773;cellular anatomical entity#GO:0110165;lytic vacuole#GO:0000323;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosidase#PC00110;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG194563|UniProtKB=T1FW73 T1FW73 20213069 PTHR24006:SF915 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE-RELATED cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 protein modification by small protein conjugation or removal#GO:0070647;mitotic cell cycle phase transition#GO:0044772;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;cell cycle G1/S phase transition#GO:0044843;cell cycle process#GO:0022402;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular process#GO:0009987;post-translational protein modification#GO:0043687;mitotic cell cycle process#GO:1903047;cell cycle phase transition#GO:0044770;primary metabolic process#GO:0044238;G1/S transition of mitotic cell cycle#GO:0000082;mitotic cell cycle#GO:0000278;nitrogen compound metabolic process#GO:0006807;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;cell cycle#GO:0007049;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185578|UniProtKB=T1FN00 T1FN00 20210199 PTHR10300:SF14 CALCIPRESSIN PROTEIN SARAH phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;calcium-mediated signaling#GO:0019722;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG87827|UniProtKB=T1G6V9 T1G6V9 20216806 PTHR48112:SF32 HIGH MOBILITY GROUP PROTEIN DSP1 HIGH MOBILITY GROUP PROTEIN B3 HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG192002|UniProtKB=T1FTI0 T1FTI0 20212127 PTHR19302:SF33 GAMMA TUBULIN COMPLEX PROTEIN GAMMA-TUBULIN COMPLEX COMPONENT 5 cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;meiotic cell cycle#GO:0051321;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule polymerization or depolymerization#GO:0031109;chromosome segregation#GO:0007059;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;reproduction#GO:0000003;microtubule polymerization#GO:0046785;microtubule-based process#GO:0007017;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;supramolecular fiber organization#GO:0097435;sexual reproduction#GO:0019953;protein polymerization#GO:0051258;spindle assembly#GO:0051225;reproductive process#GO:0022414;cell cycle#GO:0007049;cytoskeleton organization#GO:0007010;spindle organization#GO:0007051;non-membrane-bounded organelle assembly#GO:0140694;microtubule nucleation#GO:0007020;cytoplasmic microtubule organization#GO:0031122 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG194720|UniProtKB=T1FWC4 T1FWC4 20213119 PTHR31638:SF3 DAZ-ASSOCIATED PROTEIN 2 DAZ-ASSOCIATED PROTEIN 2 HELRO|EnsemblGenome=HelroG178148|UniProtKB=T1FCU4 T1FCU4 20206643 PTHR24418:SF162 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE ABL protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG165920|UniProtKB=T1EXG5 T1EXG5 20201265 PTHR24230:SF76 G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;neuropeptide signaling pathway#GO:0007218;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG69451|UniProtKB=T1FZV5 T1FZV5 20214353 PTHR19308:SF8 PHOSPHATIDYLCHOLINE TRANSFER PROTEIN STAR-RELATED LIPID TRANSFER PROTEIN 7, MITOCHONDRIAL HELRO|EnsemblGenome=HelroG132794|UniProtKB=T1EHZ6 T1EHZ6 20196196 PTHR11893:SF36 INNEXIN INNEXIN-5 cell junction protein#PC00070;gap junction#PC00105 HELRO|EnsemblGenome=HelroG179714|UniProtKB=T1FF23 T1FF23 20207422 PTHR23279:SF36 DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED DEFECTIVE PROBOSCIS EXTENSION RESPONSE 9, ISOFORM A cellular component organization or biogenesis#GO:0071840;synapse organization#GO:0050808;cellular component organization#GO:0016043;cellular process#GO:0009987;cell junction organization#GO:0034330 cell leading edge#GO:0031252;neuron projection#GO:0043005;leading edge membrane#GO:0031256;plasma membrane region#GO:0098590;cell projection membrane#GO:0031253;cell projection#GO:0042995;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG185599|UniProtKB=T1FN08 T1FN08 20210207 PTHR24155:SF10 OSTEOCLAST-STIMULATING FACTOR 1 OSTEOCLAST-STIMULATING FACTOR 1 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 HELRO|EnsemblGenome=HelroG162504|UniProtKB=T1ESR6 T1ESR6 20199616 PTHR12977:SF4 SUPPRESSOR OF VARIEGATION 4-20-RELATED HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B HELRO|EnsemblGenome=HelroG167645|UniProtKB=T1EZL9 T1EZL9 20202019 PTHR46734:SF1 TELOMERIC REPEAT-BINDING FACTOR 1 TERF1 TELOMERIC REPEAT-BINDING FACTOR 1 HELRO|EnsemblGenome=HelroG194045|UniProtKB=T1FVM0 T1FVM0 20212866 PTHR46389:SF3 POLYCOMB GROUP PROTEIN PC POLYCOMB GROUP PROTEIN PC chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG171893|UniProtKB=T1F4T2 T1F4T2 20203831 PTHR21437:SF1 WIDE AWAKE WIDE AWAKE HELRO|EnsemblGenome=HelroG193693|UniProtKB=T1FV96 T1FV96 20212742 PTHR13903:SF8 PIRIN-RELATED PIRIN transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG177051|UniProtKB=T1FB65 T1FB65 20206064 PTHR12654:SF0 BILE ACID BETA-GLUCOSIDASE-RELATED NON-LYSOSOMAL GLUCOSYLCERAMIDASE glucosidase#PC00108;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG103993|UniProtKB=T1EDJ1 T1EDJ1 20194643 PTHR11728:SF8 GLYCEROL-3-PHOSPHATE DEHYDROGENASE GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;carbohydrate derivative metabolic process#GO:1901135;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;pyridine nucleotide metabolic process#GO:0019362;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;glycerol-3-phosphate metabolic process#GO:0006072;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG140466|UniProtKB=T1EJ11 T1EJ11 20196561 PTHR45695:SF26 LEUCOKININ RECEPTOR-RELATED NEUROPEPTIDE CCHAMIDE-1 RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG185764|UniProtKB=T1FN95 T1FN95 20210293 PTHR11964:SF1 S-ADENOSYLMETHIONINE SYNTHETASE S-ADENOSYLMETHIONINE SYNTHASE transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824 sulfur compound metabolic process#GO:0006790;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 nucleotidyltransferase#PC00174 S-adenosylmethionine biosynthesis#P02773>S-Adenosyl methionine synthetase#P03143 HELRO|EnsemblGenome=HelroG98295|UniProtKB=T1G9L9 T1G9L9 20217765 PTHR15929:SF0 STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR HELRO|EnsemblGenome=HelroG175608|UniProtKB=T1F9F2 T1F9F2 20205451 PTHR25462:SF305 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG164393|UniProtKB=T1EVD4 T1EVD4 20209493 PTHR22763:SF162 RING ZINC FINGER PROTEIN TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG67935|UniProtKB=T1FZ81 T1FZ81 20214129 PTHR11200:SF300 INOSITOL 5-PHOSPHATASE TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 lipid metabolic process#GO:0006629;phospholipid dephosphorylation#GO:0046839;phosphatidylinositol dephosphorylation#GO:0046856;cellular metabolic process#GO:0044237;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;lipid modification#GO:0030258;cellular process#GO:0009987;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;dephosphorylation#GO:0016311;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 metabolite interconversion enzyme#PC00262;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG92464|UniProtKB=T1G8G7 T1G8G7 PTHR24093:SF369 CATION TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE calcium ion transmembrane transporter activity#GO:0015085;inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;P-type ion transporter activity#GO:0015662;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075 intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG140431|UniProtKB=T1EJ07 T1EJ07 20196557 PTHR11685:SF427 RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING RBR-TYPE E3 UBIQUITIN TRANSFERASE ubiquitin-like protein conjugating enzyme binding#GO:0044390;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;enzyme binding#GO:0019899;protein binding#GO:0005515;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG102572|UniProtKB=T1EDA5 T1EDA5 20194557 PTHR24361:SF433 MITOGEN-ACTIVATED KINASE KINASE KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 EGF receptor signaling pathway#P00018>MEKK1-5#P00553 HELRO|EnsemblGenome=HelroG167642|UniProtKB=T1EZL7 T1EZL7 20202017 PTHR14167:SF116 SH3 DOMAIN-CONTAINING CAP, ISOFORM AC scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG95592|UniProtKB=T1G969 T1G969 20217616 PTHR47966:SF51 BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;aspartic-type endopeptidase activity#GO:0004190;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 aspartic protease#PC00053;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG188534|UniProtKB=T1FQ38 T1FQ38 20210935 PTHR46298:SF1 ANDROGLOBIN ANDROGLOBIN HELRO|EnsemblGenome=HelroG106700|UniProtKB=T1EE38 T1EE38 20194840 PTHR13030:SF8 NUDIX HYDROLASE ADP-RIBOSE PYROPHOSPHATASE, MITOCHONDRIAL metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG155789|UniProtKB=T1ELM4 T1ELM4 20197474 PTHR11937:SF274 ACTIN BRAHMA ASSOCIATED PROTEIN 55KD actin and actin related protein#PC00039;cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG183193|UniProtKB=T1FJA0 T1FJA0 20208899 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194964|UniProtKB=T1FWM0 T1FWM0 20213215 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG167610|UniProtKB=T1EZJ9 T1EZJ9 20201999 PTHR24238:SF75 G-PROTEIN COUPLED RECEPTOR CHOLECYSTOKININ-LIKE RECEPTOR AT 17D1-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;neuropeptide signaling pathway#GO:0007218;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG178717|UniProtKB=T1FDM3 T1FDM3 20206922 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG83972|UniProtKB=T1G5C3 T1G5C3 20216270 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG191574|UniProtKB=T1FT34 T1FT34 20211981 PTHR13948:SF3 RNA-BINDING PROTEIN FI21118P1 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG193692|UniProtKB=T1FV95 T1FV95 20212741 PTHR25462:SF305 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG73491|UniProtKB=T1G1E4 T1G1E4 20214892 PTHR22761:SF12 CHARGED MULTIVESICULAR BODY PROTEIN CHARGED MULTIVESICULAR BODY PROTEIN 5 endosomal transport#GO:0016197;cellular localization#GO:0051641;membrane organization#GO:0061024;vacuolar transport#GO:0007034;transport#GO:0006810;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;vesicle-mediated transport#GO:0016192;late endosome to vacuole transport#GO:0045324;cellular component organization#GO:0016043;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;vesicle budding from membrane#GO:0006900;establishment of localization#GO:0051234;organelle organization#GO:0006996;endosome transport via multivesicular body sorting pathway#GO:0032509;establishment of localization in cell#GO:0051649;vesicle organization#GO:0016050;intracellular transport#GO:0046907 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;late endosome#GO:0005770;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG169460|UniProtKB=T1F1Y9 T1F1Y9 20202839 PTHR24034:SF205 EGF-LIKE DOMAIN-CONTAINING PROTEIN NIDOGEN extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG180676|UniProtKB=T1FG56 T1FG56 20207805 PTHR42264:SF6 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE PROTEIN HELRO|EnsemblGenome=HelroG70921|UniProtKB=T1G0E3 T1G0E3 20214541 PTHR15605:SF2 KINESIN-ASSOCIATED PROTEINS KINESIN-ASSOCIATED PROTEIN 3 cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;cell projection organization#GO:0030030;microtubule-based process#GO:0007017;organelle organization#GO:0006996;microtubule-based movement#GO:0007018;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036 axoneme#GO:0005930;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;ciliary transition zone#GO:0035869;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;microtubule associated complex#GO:0005875;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;ciliary plasm#GO:0097014;plasma membrane bounded cell projection cytoplasm#GO:0032838;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929 cytoskeletal protein#PC00085;microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG165068|UniProtKB=T1EW88 T1EW88 20200838 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG75352|UniProtKB=T1G240 T1G240 20215138 PTHR24044:SF506 NOTCH LIGAND FAMILY MEMBER NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2-LIKE protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG66424|UniProtKB=T1FYL0 T1FYL0 20213908 PTHR13680:SF5 CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 1 CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 1 small molecule binding#GO:0036094;binding#GO:0005488;iron-sulfur cluster binding#GO:0051536 envelope#GO:0031975;bounding membrane of organelle#GO:0098588;mitochondrial membrane#GO:0031966;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867 HELRO|EnsemblGenome=HelroG70090|UniProtKB=T1G027 T1G027 20214425 PTHR13720:SF18 WD-40 REPEAT PROTEIN FI23230P1 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG80378|UniProtKB=T1G401 T1G401 20215799 PTHR23113:SF368 GUANINE NUCLEOTIDE EXCHANGE FACTOR CELL DIVISION CONTROL PROTEIN 25 nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;Ras protein signal transduction#GO:0007265;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 PDGF signaling pathway#P00047>SOS#P01159;EGF receptor signaling pathway#P00018>SOS#P00558 HELRO|EnsemblGenome=HelroG79801|UniProtKB=T1G3T5 T1G3T5 20215733 PTHR24193:SF125 ANKYRIN REPEAT PROTEIN PROTEIN FEM-1 HOMOLOG CG6966-LIKE PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG165900|UniProtKB=T1EXF2 T1EXF2 20201252 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED FMRFAMIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG157766|UniProtKB=T1EMF5 T1EMF5 20197755 PTHR12001:SF44 GERANYLGERANYL PYROPHOSPHATE SYNTHASE GERANYLGERANYL PYROPHOSPHATE SYNTHASE prenyltransferase activity#GO:0004659;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;cellular lipid metabolic process#GO:0044255;isoprenoid metabolic process#GO:0006720;metabolic process#GO:0008152;isoprenoid biosynthetic process#GO:0008299;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704 metabolite interconversion enzyme#PC00262 Cholesterol biosynthesis#P00014>Dimethylallyl trans-transferase#P00490 HELRO|EnsemblGenome=HelroG192710|UniProtKB=T1FU78 T1FU78 20212374 PTHR21082:SF4 PROTEIN INTURNED PROTEIN INTURNED cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;multicellular organism development#GO:0007275;developmental process#GO:0032502;cellular component organization#GO:0016043;cellular process#GO:0009987;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;system development#GO:0048731;organelle organization#GO:0006996;anatomical structure development#GO:0048856;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection assembly#GO:0120031 cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cilium#GO:0005929;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185509|UniProtKB=T1FMW8 T1FMW8 20210167 PTHR45636:SF49 PAIRED BOX PROTEIN PAX-6-RELATED-RELATED PAIRED BOX PROTEIN 3 HOMOLOG sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG175354|UniProtKB=T1F966 T1F966 20205365 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG116724|UniProtKB=T1EGH2 T1EGH2 20195674 PTHR46212:SF3 PEFLIN GH27120P HELRO|EnsemblGenome=HelroG64810|UniProtKB=T1FXZ7 T1FXZ7 20213695 PTHR23252:SF43 INTIMAL THICKNESS RECEPTOR-RELATED INTIMAL THICKNESS RELATED RECEPTOR IRP DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164352|UniProtKB=T1EVB0 T1EVB0 20200510 PTHR15136:SF5 STROMAL INTERACTION MOLECULE HOMOLOG STROMAL INTERACTION MOLECULE HOMOLOG cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;molecular function regulator activity#GO:0098772;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;transporter regulator activity#GO:0141108;channel regulator activity#GO:0016247;ion binding#GO:0043167 inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;regulation of metal ion transport#GO:0010959;transport#GO:0006810;positive regulation of molecular function#GO:0044093;positive regulation of cation channel activity#GO:2001259;regulation of localization#GO:0032879;regulation of monoatomic cation transmembrane transport#GO:1904062;cellular homeostasis#GO:0019725;intracellular calcium ion homeostasis#GO:0006874;calcium ion transport#GO:0006816;regulation of biological process#GO:0050789;regulation of transport#GO:0051049;establishment of localization#GO:0051234;regulation of molecular function#GO:0065009;monoatomic cation transport#GO:0006812;regulation of monoatomic ion transmembrane transporter activity#GO:0032412;regulation of transmembrane transporter activity#GO:0022898;regulation of monoatomic ion transport#GO:0043269;regulation of transporter activity#GO:0032409;positive regulation of biological process#GO:0048518;regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;metal ion transport#GO:0030001;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;regulation of calcium ion transport#GO:0051924;positive regulation of transport#GO:0051050;intracellular chemical homeostasis#GO:0055082;chemical homeostasis#GO:0048878;monoatomic ion homeostasis#GO:0050801;positive regulation of cellular process#GO:0048522;localization#GO:0051179;positive regulation of transporter activity#GO:0032411;regulation of cellular process#GO:0050794;intracellular monoatomic cation homeostasis#GO:0030003;biological regulation#GO:0065007;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG102882|UniProtKB=T1EDC7 T1EDC7 20194579 PTHR24095:SF244 ACETYL-COENZYME A SYNTHETASE ACETYL-COENZYME A SYNTHETASE ligase activity#GO:0016874;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;sulfur compound metabolic process#GO:0006790;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;amide metabolic process#GO:0043603;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;acyl-CoA metabolic process#GO:0006637;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 ligase#PC00142;metabolite interconversion enzyme#PC00262 Acetate utilization#P02722>Acetyl-CoA synthetase#P02803 HELRO|EnsemblGenome=HelroG188500|UniProtKB=T1FQ21 T1FQ21 20210918 PTHR24204:SF8 INSULIN GENE ENHANCER PROTEIN TAILUP, ISOFORM A cellular developmental process#GO:0048869;neurogenesis#GO:0022008;cell projection organization#GO:0030030;multicellular organism development#GO:0007275;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;cell morphogenesis#GO:0000902;cellular component organization#GO:0016043;cell fate commitment#GO:0045165;cellular process#GO:0009987;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;cell fate specification#GO:0001708;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;cell differentiation#GO:0030154;system development#GO:0048731;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;neuron differentiation#GO:0030182;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;axonogenesis#GO:0007409;plasma membrane bounded cell projection morphogenesis#GO:0120039;generation of neurons#GO:0048699 HELRO|EnsemblGenome=HelroG157832|UniProtKB=T1EMG6 T1EMG6 20197766 PTHR22753:SF14 TRANSMEMBRANE PROTEIN 68 MONOACYLGLYCEROL_DIACYLGLYCEROL O-ACYLTRANSFERASE cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG89417|UniProtKB=T1G7C8 T1G7C8 20216975 PTHR43398:SF1 DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1 DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1 mannosyltransferase activity#GO:0000030;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG192312|UniProtKB=T1FTT6 T1FTT6 20212233 PTHR43620:SF7 GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE GDPD5-RELATED hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric diester hydrolase activity#GO:0008081;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 phosphodiesterase#PC00185;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG168373|UniProtKB=T1F0I0 T1F0I0 20202330 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG113373|UniProtKB=T1EFR9 T1EFR9 20195421 PTHR46520:SF1 SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL hydrolase activity#GO:0016787;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;biological regulation#GO:0065007;organonitrogen compound metabolic process#GO:1901564;regulation of lipid metabolic process#GO:0019216;protein metabolic process#GO:0019538;regulation of metabolic process#GO:0019222;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG181715|UniProtKB=T1FH90 T1FH90 20208189 PTHR20963:SF8 MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE 1 hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG77547|UniProtKB=T1G2Z6 T1G2Z6 20215444 PTHR11920:SF501 GUANYLYL CYCLASE GUANYLATE CYCLASE 32E adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG189989|UniProtKB=T1FRK3 T1FRK3 20211450 PTHR24068:SF168 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 J1 ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG165663|UniProtKB=T1EX53 T1EX53 20201153 PTHR16008:SF6 F-BOX ONLY PROTEIN 4 SI:DKEY-12E7.1 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234 HELRO|EnsemblGenome=HelroG194251|UniProtKB=T1FVV1 T1FVV1 20212947 PTHR23202:SF124 WASP INTERACTING PROTEIN-RELATED C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG99246|UniProtKB=T1G9R7 T1G9R7 20217813 PTHR23147:SF282 SERINE/ARGININE RICH SPLICING FACTOR RRM DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;nuclear speck#GO:0016607;organelle#GO:0043226;nuclear body#GO:0016604;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG160584|UniProtKB=T1EQG3 T1EQG3 20198813 PTHR46232:SF1 SMARCE1 REGULATOR OF CHROMATIN SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1 nucleosome binding#GO:0031491;nucleic acid binding#GO:0003676;chromatin DNA binding#GO:0031490;nuclear receptor binding#GO:0016922;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;transcription factor binding#GO:0008134;DNA-binding transcription factor binding#GO:0140297 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;ATPase complex#GO:1904949;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;SWI/SNF complex#GO:0016514;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG96981|UniProtKB=T1G9E8 T1G9E8 20217695 PTHR33904:SF1 ESSENTIAL MCU REGULATOR, MITOCHONDRIAL ESSENTIAL MCU REGULATOR, MITOCHONDRIAL inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;calcium ion transport#GO:0006816;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;mitochondrial transport#GO:0006839;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation transport#GO:0006812;mitochondrial calcium ion homeostasis#GO:0051560;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;mitochondrial transmembrane transport#GO:1990542;monoatomic cation transmembrane transport#GO:0098655 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;transporter complex#GO:1990351;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;calcium channel complex#GO:0034704;membrane#GO:0016020;organelle envelope#GO:0031967;cation channel complex#GO:0034703;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;mitochondrial envelope#GO:0005740;transmembrane transporter complex#GO:1902495;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;mitochondrial protein-containing complex#GO:0098798 HELRO|EnsemblGenome=HelroG66137|UniProtKB=T1FYH4 T1FYH4 20213872 PTHR16064:SF3 BTB POZ DOMAIN CONTAINING 7 BTB_POZ DOMAIN-CONTAINING PROTEIN 7 HELRO|EnsemblGenome=HelroG126817|UniProtKB=T1EHB1 T1EHB1 20195961 PTHR12403:SF11 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2-LIKE PROTEIN localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;vesicle tethering complex#GO:0099023;TRAPP complex#GO:0030008;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG163765|UniProtKB=T1EUF9 T1EUF9 20200209 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG89746|UniProtKB=T1G7H1 T1G7H1 20217018 PTHR32315:SF3 ADENINE PHOSPHORIBOSYLTRANSFERASE ADENINE PHOSPHORIBOSYLTRANSFERASE cation binding#GO:0043169;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;transferase activity#GO:0016740;small molecule binding#GO:0036094;glycosyltransferase activity#GO:0016757;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168;pentosyltransferase activity#GO:0016763 cellular aromatic compound metabolic process#GO:0006725;purine ribonucleoside monophosphate metabolic process#GO:0009167;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleobase metabolic process#GO:0009112;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;nucleoside monophosphate metabolic process#GO:0009123;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;purine nucleoside monophosphate metabolic process#GO:0009126;purine nucleobase metabolic process#GO:0006144;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleoside monophosphate metabolic process#GO:0009161;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;small molecule metabolic process#GO:0044281;nucleobase-containing small molecule metabolic process#GO:0055086 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 Adenine and hypoxanthine salvage pathway#P02723>Adenine phosphoribosyl transferase#P02810 HELRO|EnsemblGenome=HelroG167119|UniProtKB=T1EZ17 T1EZ17 20201817 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG183105|UniProtKB=T1FJ56 T1FJ56 20208855 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG115111|UniProtKB=T1EG66 T1EG66 20195568 PTHR22957:SF653 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN FI17814P1 nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;activation of GTPase activity#GO:0090630;biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG65195|UniProtKB=T1FY46 T1FY46 20213744 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG113902|UniProtKB=T1EFX3 T1EFX3 20195475 PTHR10937:SF0 GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING) transaminase activity#GO:0008483;transferase activity#GO:0016740;catalytic activity#GO:0003824 glycoprotein biosynthetic process#GO:0009101;cellular aromatic compound metabolic process#GO:0006725;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule modification#GO:0043412;protein modification process#GO:0036211;biosynthetic process#GO:0009058;nucleotide-sugar metabolic process#GO:0009225;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein glycosylation#GO:0006486;UDP-N-acetylglucosamine metabolic process#GO:0006047;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;protein N-linked glycosylation#GO:0006487;amino sugar metabolic process#GO:0006040;organophosphate metabolic process#GO:0019637;nucleobase-containing small molecule metabolic process#GO:0055086;glycosylation#GO:0070085;small molecule metabolic process#GO:0044281 transaminase#PC00216 O-antigen biosynthesis#P02757>Fructose-6-phosphate aminotransferase#P03051;N-acetylglucosamine metabolism#P02756>Fructose-6-phosphate aminotransferase#P03042;De novo purine biosynthesis#P02738>Amidophosphoribosyl transferase#P02905 HELRO|EnsemblGenome=HelroG194812|UniProtKB=T1FWF9 T1FWF9 20213154 PTHR24246:SF27 OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR ADENOSINE RECEPTOR, ISOFORM A G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HELRO|EnsemblGenome=HelroG76907|UniProtKB=T1G2Q9 T1G2Q9 20215357 PTHR24083:SF46 NUCLEAR HORMONE RECEPTOR STEROID RECEPTOR SEVEN-UP, ISOFORM A cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;signaling receptor activity#GO:0038023;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG171041|UniProtKB=T1F3Q9 T1F3Q9 20203458 PTHR24134:SF9 ANKYRIN REPEAT-CONTAINING PROTEIN DDB_G0279043 ANKYRIN REPEAT AND SOCS BOX PROTEIN 8 HELRO|EnsemblGenome=HelroG167799|UniProtKB=T1EZT8 T1EZT8 20202088 PTHR31802:SF50 32 KDA HEAT SHOCK PROTEIN-RELATED DEATH DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164315|UniProtKB=T1EV92 T1EV92 20200492 PTHR23033:SF49 BETA1,3-GALACTOSYLTRANSFERASE PUTATIVE-RELATED galactosyltransferase activity#GO:0008378;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG192463|UniProtKB=T1FTZ6 T1FTZ6 20212293 PTHR10877:SF183 POLYCYSTIN FAMILY MEMBER AT14535P-RELATED ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG80150|UniProtKB=T1G3Y3 T1G3Y3 20215781 PTHR46273:SF4 MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED AT19640P signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG193611|UniProtKB=T1FV65 T1FV65 20212711 PTHR15415:SF7 MITOFILIN MICOS COMPLEX SUBUNIT MIC60 HELRO|EnsemblGenome=HelroG167837|UniProtKB=T1EZV0 T1EZV0 20202100 PTHR33447:SF2 GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE transferase activity#GO:0016740;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824 cellular response to stimulus#GO:0051716;secondary metabolic process#GO:0019748;cellular response to chemical stimulus#GO:0070887;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;amide biosynthetic process#GO:0043604;response to stimulus#GO:0050896;detoxification#GO:0098754;peptide biosynthetic process#GO:0043043;response to stress#GO:0006950;secondary metabolite biosynthetic process#GO:0044550;response to chemical#GO:0042221;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;response to toxic substance#GO:0009636;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG192909|UniProtKB=T1FUF1 T1FUF1 20212447 PTHR33562:SF28 ATILLA, ISOFORM B-RELATED-RELATED PROTEIN QUIVER HELRO|EnsemblGenome=HelroG99594|UniProtKB=T1G9T9 T1G9T9 20217835 PTHR13140:SF745 MYOSIN UNCONVENTIONAL MYOSIN-VI microfilament motor activity#GO:0000146;cytoskeletal protein binding#GO:0008092;ATP-dependent activity#GO:0140657;binding#GO:0005488;actin filament binding#GO:0051015;cytoskeletal motor activity#GO:0003774;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;actin filament-based movement#GO:0030048;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;cytoskeleton#GO:0005856;plasma membrane#GO:0005886 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG143241|UniProtKB=T1EJ96 T1EJ96 20196646 PTHR13235:SF2 SINGLE-STRAND SELECTIVE MONOFUNCTIONAL URACIL DNA GLYCOSYLASE SINGLE-STRAND SELECTIVE MONOFUNCTIONAL URACIL DNA GLYCOSYLASE catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity, acting on DNA#GO:0140097;DNA N-glycosylase activity#GO:0019104;catalytic activity#GO:0003824 DNA metabolism protein#PC00009;DNA glycosylase#PC00010 HELRO|EnsemblGenome=HelroG158201|UniProtKB=T1EMK4 T1EMK4 20197804 PTHR18919:SF107 ACETYL-COA C-ACYLTRANSFERASE ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG88643|UniProtKB=T1G748 T1G748 20216895 PTHR43330:SF8 METHIONINE AMINOPEPTIDASE METHIONINE AMINOPEPTIDASE 1D, MITOCHONDRIAL metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;aminopeptidase activity#GO:0004177;exopeptidase activity#GO:0008238;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;metalloaminopeptidase activity#GO:0070006 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG174897|UniProtKB=T1F8L3 T1F8L3 20205162 PTHR23113:SF363 GUANINE NUCLEOTIDE EXCHANGE FACTOR PROTEIN SON OF SEVENLESS nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;Ras protein signal transduction#GO:0007265;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 FGF signaling pathway#P00021>SOS#P00641;Angiogenesis#P00005>SOS-1#P00193;Integrin signalling pathway#P00034>SOS#P00920;PDGF signaling pathway#P00047>SOS#P01159;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>SOS#P00883;EGF receptor signaling pathway#P00018>SOS#P00558;Ras Pathway#P04393>SOS#P04552 HELRO|EnsemblGenome=HelroG77754|UniProtKB=T1G334 T1G334 20215482 PTHR24343:SF299 SERINE/THREONINE KINASE SERINE_THREONINE-PROTEIN KINASE KIN-29 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG156427|UniProtKB=T1ELW4 T1ELW4 20197564 PTHR15377:SF3 TRANSCRIPTION ELONGATION REGULATOR 1 WW DOMAIN-CONTAINING PROTEIN molecular adaptor activity#GO:0060090;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;RNA polymerase binding#GO:0070063;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;protein binding#GO:0005515;enzyme binding#GO:0019899 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG179295|UniProtKB=T1FL79 T1FL79 20207229 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG166735|UniProtKB=T1EYG2 T1EYG2 20201612 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG86281|UniProtKB=T1G698 T1G698 20216595 PTHR11461:SF372 SERINE PROTEASE INHIBITOR, SERPIN ACCESSORY GLAND PROTEIN ACP76A-RELATED extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG193051|UniProtKB=T1FUK6 T1FUK6 20212502 PTHR12131:SF1 ATP-DEPENDENT RNA AND DNA HELICASE ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG137415|UniProtKB=T1EIK6 T1EIK6 20196406 PTHR23167:SF82 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG172059|UniProtKB=T1F4Z5 T1F4Z5 20203894 PTHR23244:SF467 KELCH REPEAT DOMAIN EF-HAND DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188469|UniProtKB=T1FQ10 T1FQ10 20210907 PTHR25462:SF291 BONUS, ISOFORM C-RELATED E3 UBIQUITIN-PROTEIN LIGASE TRIM45 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG170964|UniProtKB=T1F3M8 T1F3M8 20203427 PTHR10642:SF26 RIBONUCLEASE H1 RIBONUCLEASE H1 catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular nitrogen compound catabolic process#GO:0044270;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic cyclic compound catabolic process#GO:1901361;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;organic substance catabolic process#GO:1901575;nucleobase-containing compound catabolic process#GO:0034655;DNA replication#GO:0006260;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;cellular catabolic process#GO:0044248 endoribonuclease#PC00094;RNA metabolism protein#PC00031 DNA replication#P00017>RNase H#P00538 HELRO|EnsemblGenome=HelroG71638|UniProtKB=T1G0P5 T1G0P5 20214643 PTHR11267:SF181 T-BOX PROTEIN-RELATED OPTOMOTOR-BLIND PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HELRO|EnsemblGenome=HelroG87213|UniProtKB=T1G6N1 T1G6N1 20216728 PTHR12497:SF0 TAZ PROTEIN TAFAZZIN TAFAZZIN acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;O-acyltransferase activity#GO:0008374 acyltransferase#PC00042;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG165227|UniProtKB=T1EWG6 T1EWG6 20200916 PTHR47980:SF23 LD44762P RAB10, MEMBER RAS ONCOGENE FAMILY cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;myosin binding#GO:0017022;binding#GO:0005488 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;protein secretion#GO:0009306;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;establishment of protein localization to extracellular region#GO:0035592;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;protein transport#GO:0015031;protein localization to extracellular region#GO:0071692;export from cell#GO:0140352;secretion by cell#GO:0032940 endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;recycling endosome#GO:0055037;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;secretory vesicle#GO:0099503 TGF-beta signaling pathway#P00052>Ras-GDP#P01291;TGF-beta signaling pathway#P00052>Ras-GTP#P01280 HELRO|EnsemblGenome=HelroG158811|UniProtKB=T1ENA7 T1ENA7 20198057 PTHR10027:SF33 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic ion-gated channel activity#GO:0022839;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium-activated cation channel activity#GO:0005227;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG180975|UniProtKB=T1FGH2 T1FGH2 20207921 PTHR21461:SF69 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 glycosylation#GO:0070085;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG179723|UniProtKB=T1FF28 T1FF28 20207427 PTHR45888:SF5 HL01030P-RELATED D4, ISOFORM A HELRO|EnsemblGenome=HelroG159415|UniProtKB=T1EP07 T1EP07 20198307 PTHR46458:SF5 BLR2807 PROTEIN GLOBIN FAMILY PROFILE DOMAIN-CONTAINING PROTEIN transporter#PC00227 HELRO|EnsemblGenome=HelroG64929|UniProtKB=T1FY14 T1FY14 20213712 PTHR24230:SF75 G-PROTEIN COUPLED RECEPTOR RELAXIN FAMILY PEPTIDE RECEPTOR 3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;neuropeptide signaling pathway#GO:0007218;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG171441|UniProtKB=T1F4A2 T1F4A2 20203651 PTHR11042:SF136 EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED EIF-2-ALPHA KINASE GCN2 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG84338|UniProtKB=T1G5H6 T1G5H6 20216323 PTHR23123:SF37 PHD/F-BOX CONTAINING PROTEIN JMJC DOMAIN-CONTAINING PROTEIN-RELATED histone modifying activity#GO:0140993;molecular adaptor activity#GO:0060090;demethylase activity#GO:0032451;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;histone demethylase activity#GO:0032452;catalytic activity#GO:0003824;protein-macromolecule adaptor activity#GO:0030674;catalytic activity, acting on a protein#GO:0140096 macromolecule modification#GO:0043412;regulation of DNA-templated transcription#GO:0006355;macromolecule metabolic process#GO:0043170;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;protein metabolic process#GO:0019538;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG82547|UniProtKB=T1G4T6 T1G4T6 20216084 PTHR11707:SF28 L-ASPARAGINASE 60 KDA LYSOPHOSPHOLIPASE HELRO|EnsemblGenome=HelroG193244|UniProtKB=T1FUS5 T1FUS5 20212571 PTHR21494:SF0 ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 ASC-1 COMPLEX SUBUNIT P100 ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 protein binding#GO:0005515;ubiquitin-like protein binding#GO:0032182;binding#GO:0005488;ubiquitin binding#GO:0043130 HELRO|EnsemblGenome=HelroG72589|UniProtKB=T1G122 T1G122 20214770 PTHR15427:SF33 EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG188882|UniProtKB=T1FQF5 T1FQF5 20211052 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG186717|UniProtKB=T1FP26 T1FP26 20210573 PTHR11405:SF5 CARBAMOYLTRANSFERASE FAMILY MEMBER CAD PROTEIN ligase activity#GO:0016874;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;nitrogen compound metabolic process#GO:0006807;alpha-amino acid metabolic process#GO:1901605;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;L-amino acid metabolic process#GO:0170033;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 De novo pyrimidine ribonucleotides biosythesis#P02740>Carbamoyl phosphate synthetase#P02925;Arginine biosynthesis#P02728>Carbamoyl phosphate synthase#P02845 HELRO|EnsemblGenome=HelroG161614|UniProtKB=T1ERQ0 T1ERQ0 20199250 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186046|UniProtKB=T1FNL3 T1FNL3 20210410 PTHR45619:SF8 SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 4 CATALYTIC SUBUNIT hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;double-strand break repair via homologous recombination#GO:0000724;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;response to stress#GO:0006950;nitrogen compound metabolic process#GO:0006807;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 EGF receptor signaling pathway#P00018>PP2A#P00547;FGF signaling pathway#P00021>PP2A#P00629 HELRO|EnsemblGenome=HelroG85838|UniProtKB=T1G633 T1G633 20216530 PTHR10024:SF227 SYNAPTOTAGMIN SYNAPTOTAGMIN 1 cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;phosphatidylserine binding#GO:0001786;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;protein binding#GO:0005515;clathrin binding#GO:0030276;lipid binding#GO:0008289;ion binding#GO:0043167;phospholipid binding#GO:0005543;SNARE binding#GO:0000149 cellular localization#GO:0051641;synaptic vesicle cycle#GO:0099504;synaptic vesicle endocytosis#GO:0048488;transport#GO:0006810;regulation of biological process#GO:0050789;regulated exocytosis#GO:0045055;synaptic vesicle recycling#GO:0036465;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;secretion#GO:0046903;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;signal release#GO:0023061;calcium-ion regulated exocytosis#GO:0017156;cell-cell signaling#GO:0007267;signaling#GO:0023052;synaptic vesicle exocytosis#GO:0016079;secretion by cell#GO:0032940;neurotransmitter secretion#GO:0007269;endocytosis#GO:0006897;trans-synaptic signaling#GO:0099537;vesicle-mediated transport#GO:0016192;cell communication#GO:0007154;cellular process#GO:0009987;localization#GO:0051179;signal release from synapse#GO:0099643;exocytosis#GO:0006887;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;import into cell#GO:0098657;export from cell#GO:0140352;vesicle-mediated transport in synapse#GO:0099003 intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;secretory vesicle#GO:0099503;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG75164|UniProtKB=T1G218 T1G218 20215116 PTHR24033:SF193 EGF-LIKE DOMAIN-CONTAINING PROTEIN NETRIN-G1-RELATED Axon guidance mediated by netrin#P00009>Netrin#P00357;Axon guidance mediated by Slit/Robo#P00008>Netrin#P00344 HELRO|EnsemblGenome=HelroG93424|UniProtKB=T1G8V8 T1G8V8 20217505 PTHR10221:SF9 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6 transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;RNA metabolic process#GO:0016070;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;RNA polymerase II preinitiation complex assembly#GO:0051123;transcription initiation at RNA polymerase II promoter#GO:0006367;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;DNA-directed RNA polymerase complex#GO:0000428;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nucleoplasm#GO:0005654;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;transcription factor TFIID complex#GO:0005669;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;transcription regulator complex#GO:0005667;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 general transcription factor#PC00259 General transcription regulation#P00023>TBP-associated factors#P00658;General transcription regulation#P00023>TBP#P00670;Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385 HELRO|EnsemblGenome=HelroG165909|UniProtKB=T1EXF8 T1EXF8 20201258 PTHR13434:SF0 PROTEIN CASC3 PROTEIN CASC3 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG193770|UniProtKB=T1FVC3 T1FVC3 20212769 PTHR11360:SF260 MONOCARBOXYLATE TRANSPORTER MFS DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;monocarboxylic acid transmembrane transporter activity#GO:0008028;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;monocarboxylic acid transport#GO:0015718;establishment of localization#GO:0051234;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942 transporter#PC00227 HELRO|EnsemblGenome=HelroG186992|UniProtKB=T1FP50 T1FP50 20210597 PTHR10665:SF0 RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS SUPPRESSOR OF HAIRLESS PROTEIN cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 Notch signaling pathway#P00045>Su(H)#P01101;Alzheimer disease-presenilin pathway#P00004>CSL#P00158;Angiogenesis#P00005>CSL#P00233 HELRO|EnsemblGenome=HelroG110749|UniProtKB=T1EF50 T1EF50 20195202 PTHR24353:SF153 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;cytosol#GO:0005829;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Enkephalin release#P05913>PKA#P05972;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Endothelin signaling pathway#P00019>PKA#P00570;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059 HELRO|EnsemblGenome=HelroG192329|UniProtKB=T1FTU1 T1FTU1 20212238 PTHR12929:SF10 SOLUTE CARRIER FAMILY 52 RIBOFLAVIN TRANSPORTER transmembrane transporter activity#GO:0022857;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215 localization#GO:0051179;vitamin transport#GO:0051180;nitrogen compound transport#GO:0071705;organic substance transport#GO:0071702;establishment of localization#GO:0051234;organic anion transport#GO:0015711;transport#GO:0006810 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG168250|UniProtKB=T1F0C8 T1F0C8 20202278 PTHR45862:SF1 PROTEIN SGT1 HOMOLOG PROTEIN SGT1 HOMOLOG HELRO|EnsemblGenome=HelroG112090|UniProtKB=T1EFH0 T1EFH0 20195322 PTHR11675:SF43 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 1 transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG180677|UniProtKB=T1FG57 T1FG57 20207806 PTHR46513:SF13 VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG81292|UniProtKB=T1G4C7 T1G4C7 20215925 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG64460|UniProtKB=T1FXV4 T1FXV4 20213652 PTHR23292:SF6 LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR FI16602P1-RELATED cation binding#GO:0043169;metal ion binding#GO:0046872;ion binding#GO:0043167;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;binding#GO:0005488;transition metal ion binding#GO:0046914 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG150812|UniProtKB=T1EKH5 T1EKH5 20197075 PTHR44899:SF3 CAMK FAMILY PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE NEK1 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG160967|UniProtKB=T1EQX7 T1EQX7 20198977 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174471|UniProtKB=T1F857 T1F857 20205006 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG62577|UniProtKB=T1FX25 T1FX25 20213373 PTHR12486:SF4 APRATAXIN-RELATED APRATAXIN hydrolase activity, acting on ester bonds#GO:0016788;nucleic acid binding#GO:0003676;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;nuclease activity#GO:0004518;DNA exonuclease activity#GO:0004529;5'-3' exonuclease activity#GO:0008409;binding#GO:0005488;catalytic activity#GO:0003824;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;single-stranded DNA binding#GO:0003697;damaged DNA binding#GO:0003684;catalytic activity, acting on a nucleic acid#GO:0140640;double-stranded DNA binding#GO:0003690;exonuclease activity#GO:0004527;RNA binding#GO:0003723;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;hydrolase activity#GO:0016787;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097;double-stranded RNA binding#GO:0003725 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 damaged DNA-binding protein#PC00086;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG193192|UniProtKB=T1FUQ4 T1FUQ4 20212550 PTHR24020:SF20 COLLAGEN ALPHA PH DOMAIN-CONTAINING PROTEIN extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG67653|UniProtKB=T1FZ35 T1FZ35 20214083 PTHR23304:SF183 SPOT2-RELATED T. BRUCEI SPP.-SPECIFIC PROTEIN HELRO|EnsemblGenome=HelroG77563|UniProtKB=T1G2Z9 T1G2Z9 20215447 PTHR23304:SF183 SPOT2-RELATED T. BRUCEI SPP.-SPECIFIC PROTEIN HELRO|EnsemblGenome=HelroG75052|UniProtKB=T1G1Z8 T1G1Z8 20215096 PTHR11453:SF127 ANION EXCHANGE PROTEIN SOLUTE CARRIER FAMILY 4 MEMBER 11 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;homeostatic process#GO:0042592;cellular process#GO:0009987;chemical homeostasis#GO:0048878;monoatomic ion homeostasis#GO:0050801 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG71646|UniProtKB=T1G0P7 T1G0P7 20214645 PTHR11080:SF2 PYRAZINAMIDASE/NICOTINAMIDASE LD05707P HELRO|EnsemblGenome=HelroG158303|UniProtKB=T1EMM1 T1EMM1 20197821 PTHR46114:SF2 APPLE DOMAIN-CONTAINING PROTEIN CULLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194761|UniProtKB=T1FWD9 T1FWD9 20213134 PTHR42757:SF32 IGLON FAMILY OF IMMUNOGLOBULIN SUPERFAMILY-RELATED PROTEIN AMALGAM defense/immunity protein#PC00090;immunoglobulin#PC00123 HELRO|EnsemblGenome=HelroG158058|UniProtKB=T1EMI9 T1EMI9 20197789 PTHR11545:SF3 RIBOSOMAL PROTEIN L13 LARGE RIBOSOMAL SUBUNIT PROTEIN UL13 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of protein metabolic process#GO:0051246;negative regulation of biosynthetic process#GO:0009890;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of translation#GO:0017148;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG101841|UniProtKB=T1ED73 T1ED73 20194525 PTHR45963:SF2 RE52028P RE52028P HELRO|EnsemblGenome=HelroG179444|UniProtKB=T1FEQ3 T1FEQ3 20207302 PTHR21669:SF28 CAPZ-INTERACTING PROTEIN AND RELATED PROTEINS YEMANUCLEIN cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;protein-DNA complex organization#GO:0071824;cellular component organization#GO:0016043;cellular process#GO:0009987;protein-containing complex organization#GO:0043933 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG188954|UniProtKB=T1FQI0 T1FQI0 20211077 PTHR11675:SF134 N-ACETYLGALACTOSAMINYLTRANSFERASE N-ACETYLGALACTOSAMINYLTRANSFERASE 4-RELATED transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG111661|UniProtKB=T1EFD3 T1EFD3 20195285 PTHR23308:SF66 NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1 KANADAPTIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG76071|UniProtKB=T1G2E6 T1G2E6 20215244 PTHR12072:SF5 CWF19, CELL CYCLE CONTROL PROTEIN CWF19-LIKE PROTEIN 2 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;post-mRNA release spliceosomal complex#GO:0071014;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG79698|UniProtKB=T1G3S3 T1G3S3 20215721 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN SI:DKEY-17M8.2 HELRO|EnsemblGenome=HelroG161862|UniProtKB=T1ERZ1 T1ERZ1 20199341 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG189943|UniProtKB=T1FRI5 T1FRI5 20211432 PTHR46077:SF5 E3 UBIQUITIN-PROTEIN LIGASE TOPORS RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein monoubiquitination#GO:0006513;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG177900|UniProtKB=T1FCG1 T1FCG1 20206510 PTHR34524:SF17 CALCYPHOSIN CHROMOSOME UNDETERMINED SCAFFOLD_48, WHOLE GENOME SHOTGUN SEQUENCE calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG192867|UniProtKB=T1FUD7 T1FUD7 20212433 PTHR10758:SF1 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3 COP9 SIGNALOSOME COMPLEX SUBUNIT 3 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;COP9 signalosome#GO:0008180;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG162517|UniProtKB=T1ESS4 T1ESS4 20199624 PTHR12623:SF10 NGFI-A BINDING PROTEIN NGFI-A-BINDING PROTEIN HOMOLOG molecular adaptor activity#GO:0060090;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;protein binding#GO:0005515;transcription factor binding#GO:0008134;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG105607|UniProtKB=T1EDW6 T1EDW6 20194768 PTHR12153:SF15 SELENOPROTEIN O PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL HELRO|EnsemblGenome=HelroG182585|UniProtKB=T1FIE8 T1FIE8 20208597 PTHR22929:SF0 RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG181411|UniProtKB=T1FGZ2 T1FGZ2 20208091 PTHR45647:SF139 OS02G0152300 PROTEIN OS02G0152300 PROTEIN HELRO|EnsemblGenome=HelroG176110|UniProtKB=T1FA52 T1FA52 20205701 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159451|UniProtKB=T1EP20 T1EP20 20198320 PTHR24068:SF132 UBIQUITIN-CONJUGATING ENZYME E2 NEDD8-CONJUGATING ENZYME UBC12 ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein neddylation#GO:0045116;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG189194|UniProtKB=T1FQR8 T1FQR8 20211165 PTHR45766:SF3 DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 hydrolase activity, acting on ester bonds#GO:0016788;DNA endonuclease activity#GO:0004520;nuclease activity#GO:0004518;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;response to stress#GO:0006950;nitrogen compound metabolic process#GO:0006807;DNA-templated DNA replication#GO:0006261;replication fork processing#GO:0031297;DNA replication#GO:0006260;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;chromosome#GO:0005694;nuclear replication fork#GO:0043596;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;replication fork#GO:0005657 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG64563|UniProtKB=T1FXW5 T1FXW5 20213663 PTHR19134:SF534 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE LD27988P hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG64118|UniProtKB=T1FXP8 T1FXP8 20213596 PTHR13304:SF0 GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;phospholipid biosynthetic process#GO:0008654;macromolecule modification#GO:0043412;phosphatidylinositol biosynthetic process#GO:0006661;organophosphate biosynthetic process#GO:0090407;glycolipid metabolic process#GO:0006664;protein modification process#GO:0036211;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;glycerolipid biosynthetic process#GO:0045017;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;organic substance biosynthetic process#GO:1901576;liposaccharide metabolic process#GO:1903509;cellular process#GO:0009987;membrane lipid biosynthetic process#GO:0046467;GPI anchor metabolic process#GO:0006505;lipoprotein biosynthetic process#GO:0042158;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;GPI anchor biosynthetic process#GO:0006506;membrane lipid metabolic process#GO:0006643;glycerophospholipid biosynthetic process#GO:0046474;glycolipid biosynthetic process#GO:0009247;organophosphate metabolic process#GO:0019637;lipoprotein metabolic process#GO:0042157;cellular lipid metabolic process#GO:0044255 membrane protein complex#GO:0098796;peptidase complex#GO:1905368;endoplasmic reticulum protein-containing complex#GO:0140534;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endopeptidase complex#GO:1905369;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG105249|UniProtKB=T1EDS2 T1EDS2 20194724 PTHR22624:SF49 CYSTEINE PROTEASE ATG4 CYSTEINE PROTEASE cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197 microautophagy#GO:0016237;cellular component biogenesis#GO:0044085;macroautophagy#GO:0016236;macromolecule modification#GO:0043412;mitophagy#GO:0000423;protein modification process#GO:0036211;gene expression#GO:0010467;autophagy of mitochondrion#GO:0000422;biosynthetic process#GO:0009058;post-translational protein modification#GO:0043687;protein processing#GO:0016485;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;cellular component disassembly#GO:0022411;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;mitochondrion organization#GO:0007005;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organelle disassembly#GO:1903008;lipoprotein biosynthetic process#GO:0042158;primary metabolic process#GO:0044238;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;autophagosome assembly#GO:0000045;lipoprotein metabolic process#GO:0042157;autophagy#GO:0006914;piecemeal microautophagy of the nucleus#GO:0034727 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG157541|UniProtKB=T1EMD0 T1EMD0 20197730 PTHR10766:SF177 TRANSMEMBRANE 9 SUPERFAMILY PROTEIN TRANSMEMBRANE 9 SUPERFAMILY MEMBER 1 localization#GO:0051179;localization within membrane#GO:0051668;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;cellular process#GO:0009987;protein localization#GO:0008104 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG165017|UniProtKB=T1EW51 T1EW51 20200801 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182522|UniProtKB=T1FIB3 T1FIB3 20208562 PTHR19282:SF431 TETRASPANIN TETRASPANIN 26A, ISOFORM B-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG193319|UniProtKB=T1FUV7 T1FUV7 20212603 PTHR21228:SF40 FAST LEU-RICH DOMAIN-CONTAINING LD45607P RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;regulation of mRNA stability#GO:0043488;regulation of mRNA catabolic process#GO:0061013;regulation of catabolic process#GO:0009894;regulation of nitrogen compound metabolic process#GO:0051171;RNA metabolic process#GO:0016070;mitochondrial gene expression#GO:0140053;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;regulation of biological quality#GO:0065008;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;mitochondrial RNA metabolic process#GO:0000959;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;regulation of cellular catabolic process#GO:0031329;regulation of RNA stability#GO:0043487;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;mitochondrial RNA processing#GO:0000963;primary metabolic process#GO:0044238;regulation of primary metabolic process#GO:0080090;nucleic acid metabolic process#GO:0090304;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;supramolecular complex#GO:0099080;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG97204|UniProtKB=T1G9G0 T1G9G0 20217707 PTHR24416:SF634 TYROSINE-PROTEIN KINASE RECEPTOR DISCOIDIN DOMAIN-CONTAINING RECEPTOR TYROSINE KINASE B signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888;transferase activity#GO:0016740;transmembrane receptor protein kinase activity#GO:0019199;collagen binding#GO:0005518;molecular transducer activity#GO:0060089;protein-containing complex binding#GO:0044877;catalytic activity, acting on a protein#GO:0140096 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;regulation of cellular component organization#GO:0051128;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;regulation of plasma membrane bounded cell projection organization#GO:0120035;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;regulation of neuron projection development#GO:0010975;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;anatomical structure development#GO:0048856;regulation of cell projection organization#GO:0031344;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG66737|UniProtKB=T1FYQ1 T1FYQ1 20213949 PTHR14233:SF4 DUF914-RELATED SOLUTE CARRIER FAMILY 35 MEMBER F2 HELRO|EnsemblGenome=HelroG85978|UniProtKB=T1G655 T1G655 20216552 PTHR14710:SF2 GEM-ASSOCIATED PROTEIN 6 GEM-ASSOCIATED PROTEIN 6 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;spliceosomal snRNP assembly#GO:0000387;organic substance metabolic process#GO:0071704;mRNA splicing, via spliceosome#GO:0000398;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375 SMN-Sm protein complex#GO:0034719;cytoplasm#GO:0005737;SMN complex#GO:0032797;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;Sm-like protein family complex#GO:0120114;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG177634|UniProtKB=T1FBZ2 T1FBZ2 20206341 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG185576|UniProtKB=T1FMZ9 T1FMZ9 20210198 PTHR47385:SF14 CALPONIN TRANSGELIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG165431|UniProtKB=T1EWS1 T1EWS1 20201021 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG78607|UniProtKB=T1G3D7 T1G3D7 20215585 PTHR12768:SF4 BECLIN 1 BECLIN-1 molecular adaptor activity#GO:0060090;protein binding#GO:0005515;phosphatidylinositol 3-kinase binding#GO:0043548;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674 cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;macroautophagy#GO:0016236;transport#GO:0006810;mitophagy#GO:0000423;late endosome to vacuole transport#GO:0045324;autophagy of mitochondrion#GO:0000422;response to extracellular stimulus#GO:0009991;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;cellular component disassembly#GO:0022411;cellular response to starvation#GO:0009267;establishment of localization#GO:0051234;catabolic process#GO:0009056;mitochondrion organization#GO:0007005;cellular response to extracellular stimulus#GO:0031668;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;cellular component assembly#GO:0022607;cellular response to stimulus#GO:0051716;vacuolar transport#GO:0007034;cellular metabolic process#GO:0044237;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cell communication#GO:0007154;response to nutrient levels#GO:0031667;cellular process#GO:0009987;organelle disassembly#GO:1903008;localization#GO:0051179;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to stress#GO:0006950;organelle organization#GO:0006996;cellular response to nutrient levels#GO:0031669;response to starvation#GO:0042594;cellular response to external stimulus#GO:0071496;autophagosome assembly#GO:0000045;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular response to stress#GO:0033554;autophagy#GO:0006914 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;phagophore assembly site#GO:0000407;phosphatidylinositol 3-kinase complex#GO:0005942;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;membrane#GO:0016020;phosphatidylinositol 3-kinase complex, class III#GO:0035032;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;extrinsic component of membrane#GO:0019898 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG71857|UniProtKB=T1G0S4 T1G0S4 20214672 PTHR22951:SF5 CLATHRIN ASSEMBLY PROTEIN PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP phosphatidylinositol bisphosphate binding#GO:1902936;small molecule binding#GO:0036094;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;binding#GO:0005488;protein binding#GO:0005515;clathrin binding#GO:0030276;lipid binding#GO:0008289;ion binding#GO:0043167;anion binding#GO:0043168;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981;SNARE binding#GO:0000149 localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;vesicle budding from membrane#GO:0006900;establishment of localization#GO:0051234;membrane organization#GO:0061024;organelle organization#GO:0006996;clathrin-dependent endocytosis#GO:0072583;transport#GO:0006810;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;vesicle organization#GO:0016050;cellular component organization#GO:0016043;receptor-mediated endocytosis#GO:0006898;cellular process#GO:0009987;import into cell#GO:0098657 cytoplasm#GO:0005737;clathrin-coated vesicle#GO:0030136;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;clathrin-coated pit#GO:0005905;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG112986|UniProtKB=T1EFP2 T1EFP2 20195394 PTHR43651:SF3 1,4-ALPHA-GLUCAN-BRANCHING ENZYME 1,4-ALPHA-GLUCAN-BRANCHING ENZYME transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 carbohydrate metabolic process#GO:0005975;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 amylase#PC00048;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG84056|UniProtKB=T1G5E1 T1G5E1 20216288 PTHR15825:SF0 UBIQUITIN-FOLD MODIFIER 1 UBIQUITIN-FOLD MODIFIER 1 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG162085|UniProtKB=T1ES85 T1ES85 20199435 PTHR19972:SF10 CALBINDIN CALBINDIN-32 cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;intracellular monoatomic cation homeostasis#GO:0030003;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic ion homeostasis#GO:0006873;cellular homeostasis#GO:0019725;regulation of cytosolic calcium ion concentration#GO:0051480;intracellular chemical homeostasis#GO:0055082;chemical homeostasis#GO:0048878;intracellular calcium ion homeostasis#GO:0006874;monoatomic ion homeostasis#GO:0050801 cytoplasm#GO:0005737;synapse#GO:0045202;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;neuron projection#GO:0043005;cell junction#GO:0030054;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG181266|UniProtKB=T1FGT5 T1FGT5 20208034 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG104475|UniProtKB=T1EDL8 T1EDL8 20194670 PTHR11351:SF31 ACYL-COA DESATURASE DESATURASE 1, ISOFORM A-RELATED HELRO|EnsemblGenome=HelroG164499|UniProtKB=T1EVI4 T1EVI4 20200584 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG107565|UniProtKB=T1EEB3 T1EEB3 20194915 PTHR23235:SF161 KRUEPPEL-LIKE TRANSCRIPTION FACTOR C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG163490|UniProtKB=T1EU45 T1EU45 20200095 PTHR10891:SF918 EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN CALCIUM-BINDING PROTEIN 2 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG186231|UniProtKB=T1FNU5 T1FNU5 20210492 PTHR23426:SF65 FERREDOXIN/ADRENODOXIN FERREDOXIN-2, MITOCHONDRIAL cellular metabolic process#GO:0044237;electron transport chain#GO:0022900;cellular process#GO:0009987;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152 oxidoreductase#PC00176 Vitamin D metabolism and pathway#P04396>FDX#P04607 HELRO|EnsemblGenome=HelroG153379|UniProtKB=T1EL60 T1EL60 20197310 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG88960|UniProtKB=T1G777 T1G777 20216924 PTHR12612:SF9 NUCLEAR TRANSPORT FACTOR 2 NTF2-RELATED EXPORT PROTEIN 2-RELATED poly(A)+ mRNA export from nucleus#GO:0016973;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;mRNA transport#GO:0051028;RNA localization#GO:0006403;localization#GO:0051179;organic substance transport#GO:0071702;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 envelope#GO:0031975;nuclear pore#GO:0005643;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG179452|UniProtKB=T1FEQ7 T1FEQ7 20207306 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165508|UniProtKB=T1EWY0 T1EWY0 20201080 PTHR48034:SF6 TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED TRANSFORMER-2 SEX-DETERMINING PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 positive regulation of gene expression#GO:0010628;positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of mRNA metabolic process#GO:1903313;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of mRNA processing#GO:0050684;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule biosynthetic process#GO:0010556;regulation of mRNA splicing, via spliceosome#GO:0048024;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG67237|UniProtKB=T1FYY5 T1FYY5 20214033 PTHR10553:SF5 SMALL NUCLEAR RIBONUCLEOPROTEIN U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG89290|UniProtKB=T1G7B5 T1G7B5 20216962 PTHR45951:SF3 PROTEIN DISPATCHED-RELATED PROTEIN DISPATCHED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;smoothened signaling pathway#GO:0007224;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG172062|UniProtKB=T1F4Z6 T1F4Z6 20203895 PTHR18945:SF925 NEUROTRANSMITTER GATED ION CHANNEL DUF4706 DOMAIN-CONTAINING PROTEIN ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG167854|UniProtKB=T1EZV8 T1EZV8 20202108 PTHR19303:SF71 TRANSPOSON ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG155569|UniProtKB=T1ELI9 T1ELI9 20197439 PTHR24347:SF412 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE H1 HOMOLOG-RELATED non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CaMK#P00847;Ionotropic glutamate receptor pathway#P00037>CaMKII#P01023 HELRO|EnsemblGenome=HelroG63669|UniProtKB=T1FXI8 T1FXI8 20213536 PTHR10763:SF26 CELL DIVISION CONTROL PROTEIN 6-RELATED CELL DIVISION CONTROL PROTEIN 6 HOMOLOG DNA metabolism protein#PC00009;replication origin binding protein#PC00199 HELRO|EnsemblGenome=HelroG156397|UniProtKB=T1ELV5 T1ELV5 20197555 PTHR22981:SF7 3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED 3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG184815|UniProtKB=T1FM16 T1FM16 20209865 PTHR10504:SF131 BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED BPI2 DOMAIN-CONTAINING PROTEIN defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG193429|UniProtKB=T1FUZ2 T1FUZ2 20212638 PTHR22600:SF57 BETA-HEXOSAMINIDASE BETA-N-ACETYLHEXOSAMINIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 glycosaminoglycan metabolic process#GO:0030203;carbohydrate derivative metabolic process#GO:1901135;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;aminoglycan metabolic process#GO:0006022;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;membrane#GO:0016020 glycosidase#PC00110;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG153316|UniProtKB=T1EL34 T1EL34 20197358 PTHR46289:SF17 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166893|UniProtKB=T1EYQ0 T1EYQ0 20201700 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185412|UniProtKB=T1FMS3 T1FMS3 20210122 PTHR11751:SF29 ALANINE AMINOTRANSFERASE ALANINE TRANSAMINASE transaminase#PC00216;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG92549|UniProtKB=T1G8I4 T1G8I4 20217381 PTHR24248:SF199 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR IP13425P-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;regulation of cell communication#GO:0010646;cellular response to stimulus#GO:0051716;regulation of MAPK cascade#GO:0043408;signal transduction#GO:0007165;positive regulation of signal transduction#GO:0009967;regulation of signaling#GO:0023051;cell communication#GO:0007154;cellular process#GO:0009987;regulation of intracellular signal transduction#GO:1902531;positive regulation of MAPK cascade#GO:0043410;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;positive regulation of response to stimulus#GO:0048584;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;positive regulation of cell communication#GO:0010647;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG183582|UniProtKB=T1FJV5 T1FJV5 20209104 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG113277|UniProtKB=T1EFR3 T1EFR3 20195415 PTHR21245:SF10 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN SYNCRIP, ISOFORM Q-RELATED nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG194656|UniProtKB=T1FWA2 T1FWA2 20213098 PTHR11079:SF149 CYTOSINE DEAMINASE FAMILY MEMBER TRNA-SPECIFIC ADENOSINE DEAMINASE 2 hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;adenosine deaminase activity#GO:0004000;tRNA-specific adenosine deaminase activity#GO:0008251;deaminase activity#GO:0019239;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;adenosine to inosine editing#GO:0006382;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 deaminase#PC00088;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 Salvage pyrimidine ribonucleotides#P02775>Cytosine deaminase#P03155;Salvage pyrimidine ribonucleotides#P02775>Cytidine deaminase#P03154;Salvage pyrimidine deoxyribonucleotides#P02774>Cytidine deaminase#P03144;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dCTP deaminase#P02920 HELRO|EnsemblGenome=HelroG145252|UniProtKB=T1EJJ7 T1EJJ7 20196747 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG161220|UniProtKB=T1ER82 T1ER82 20199082 PTHR21580:SF28 SHIPPO-1-RELATED BOREALIN N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED structural protein#PC00211 HELRO|EnsemblGenome=HelroG87651|UniProtKB=T1G6T7 T1G6T7 20216784 PTHR10972:SF141 OXYSTEROL-BINDING PROTEIN-RELATED OXYSTEROL-BINDING PROTEIN binding#GO:0005488;organic cyclic compound binding#GO:0097159;steroid binding#GO:0005496;sterol transporter activity#GO:0015248;sterol binding#GO:0032934;lipid binding#GO:0008289;lipid transporter activity#GO:0005319;transporter activity#GO:0005215 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG163447|UniProtKB=T1EU23 T1EU23 20200073 PTHR21694:SF18 COILED-COIL DOMAIN-CONTAINING PROTEIN 63 COILED-COIL DOMAIN-CONTAINING PROTEIN 63 HELRO|EnsemblGenome=HelroG96849|UniProtKB=T1G9D8 T1G9D8 20217685 PTHR24353:SF111 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE SUBFAMILY NOT NAMED non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Endothelin signaling pathway#P00019>PKG#P00567 HELRO|EnsemblGenome=HelroG131179|UniProtKB=T1EHV5 T1EHV5 20196155 PTHR14057:SF47 TRANSCRIPTION FACTOR ONECUT HOMEOBOX PROTEIN ONECUT sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG132748|UniProtKB=T1EHZ3 T1EHZ3 20196193 PTHR24392:SF56 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 510 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG72628|UniProtKB=T1G129 T1G129 20214777 PTHR13172:SF0 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10 B envelope#GO:0031975;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;transporter complex#GO:1990351;intracellular organelle lumen#GO:0070013;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;mitochondrial intermembrane space#GO:0005758;mitochondrial protein-containing complex#GO:0098798 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG168879|UniProtKB=T1F133 T1F133 20202533 PTHR15528:SF11 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1 PGC-1 -RELATED FI18188P1 molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;nuclear receptor coactivator activity#GO:0030374;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;protein binding#GO:0005515;transcription factor binding#GO:0008134 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of molecular function#GO:0044093;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;regulation of DNA-binding transcription factor activity#GO:0051090;regulation of DNA-templated transcription#GO:0006355;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;positive regulation of DNA-binding transcription factor activity#GO:0051091;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG169535|UniProtKB=T1F220 T1F220 20202870 PTHR21505:SF15 MADF DOMAIN-CONTAINING PROTEIN-RELATED RE18252P HELRO|EnsemblGenome=HelroG93534|UniProtKB=T1G8W4 T1G8W4 20217511 PTHR45746:SF6 LP21163P LP21163P nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of cell communication#GO:0010646;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;regulation of signaling#GO:0023051;positive regulation of molecular function#GO:0044093;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;regulation of molecular function#GO:0065009;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731 HELRO|EnsemblGenome=HelroG105624|UniProtKB=T1EDW7 T1EDW7 20194769 PTHR10159:SF528 DUAL SPECIFICITY PROTEIN PHOSPHATASE PUCKERED, ISOFORM A hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 regulation of MAPK cascade#GO:0043408;negative regulation of biological process#GO:0048519;peptidyl-tyrosine dephosphorylation#GO:0035335;macromolecule modification#GO:0043412;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;protein modification process#GO:0036211;regulation of intracellular signal transduction#GO:1902531;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;negative regulation of MAPK cascade#GO:0043409;nitrogen compound metabolic process#GO:0006807;regulation of signal transduction#GO:0009966;protein metabolic process#GO:0019538;negative regulation of cellular process#GO:0048523;negative regulation of cell communication#GO:0010648;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;regulation of cell communication#GO:0010646;negative regulation of response to stimulus#GO:0048585;macromolecule metabolic process#GO:0043170;negative regulation of signaling#GO:0023057;cellular metabolic process#GO:0044237;protein dephosphorylation#GO:0006470;organonitrogen compound metabolic process#GO:1901564;cellular process#GO:0009987;primary metabolic process#GO:0044238;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;dephosphorylation#GO:0016311;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG188076|UniProtKB=T1FPL7 T1FPL7 20210764 PTHR21540:SF3 RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2 E3 UBIQUITIN-PROTEIN LIGASE ZSWIM2 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191698|UniProtKB=T1FT79 T1FT79 20212026 PTHR24409:SF422 ZINC FINGER PROTEIN 142 C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG188743|UniProtKB=T1FQB6 T1FQB6 20211013 PTHR23167:SF69 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED FI18193P1 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG180278|UniProtKB=T1FFN9 T1FFN9 20207638 PTHR46467:SF1 TETHER CONTAINING UBX DOMAIN FOR GLUT4 TETHER CONTAINING UBX DOMAIN FOR GLUT4 localization#GO:0051179;organic substance transport#GO:0071702;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;protein transport#GO:0015031;nitrogen compound transport#GO:0071705;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG86412|UniProtKB=T1G6B8 T1G6B8 20216615 PTHR10264:SF127 BAND 7 PROTEIN-RELATED PODOCIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG156472|UniProtKB=T1ELX3 T1ELX3 20197573 PTHR10539:SF0 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 peptidase complex#GO:1905368;proteasome accessory complex#GO:0022624;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;proteasome regulatory particle#GO:0005838;catalytic complex#GO:1902494;proteasome regulatory particle, lid subcomplex#GO:0008541;proteasome complex#GO:0000502;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endopeptidase complex#GO:1905369;membrane-bounded organelle#GO:0043227 protease#PC00190;protein modifying enzyme#PC00260 Parkinson disease#P00049>19S proteasome#P01209;Ubiquitin proteasome pathway#P00060>26S proteasome#P01489;Cell cycle#P00013>Proteasome#P00480 HELRO|EnsemblGenome=HelroG89299|UniProtKB=T1G7B8 T1G7B8 20216965 PTHR11475:SF58 OXIDASE/PEROXIDASE PEROXIDASIN oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;antioxidant activity#GO:0016209;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 peroxidase#PC00180;metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG108698|UniProtKB=T1EEL6 T1EEL6 20195018 PTHR45903:SF1 GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1 GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1 cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;ribosome biogenesis#GO:0042254;cellular process#GO:0009987;ribonucleoprotein complex biogenesis#GO:0022613 membrane-enclosed lumen#GO:0031974;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG160090|UniProtKB=T1EPR8 T1EPR8 20198568 PTHR47510:SF3 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG92484|UniProtKB=T1G8H2 T1G8H2 20217369 PTHR11863:SF226 STEROL DESATURASE FATTY ACID HYDROXYLASE DOMAIN-CONTAINING PROTEIN 2-RELATED oxidase#PC00175;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG87912|UniProtKB=T1G6W7 T1G6W7 20216814 PTHR22895:SF0 ARMADILLO REPEAT-CONTAINING PROTEIN 6 ARMADILLO REPEAT-CONTAINING PROTEIN 6 HELRO|EnsemblGenome=HelroG194412|UniProtKB=T1FW11 T1FW11 20213007 PTHR46989:SF3 USP DOMAIN-CONTAINING PROTEIN USPA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG105994|UniProtKB=T1EDZ1 T1EDZ1 20194793 PTHR22588:SF3 VWFA DOMAIN-CONTAINING PROTEIN VWFA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG73313|UniProtKB=T1G1C8 T1G1C8 20214876 PTHR24208:SF168 LIM/HOMEOBOX PROTEIN LHX PROTEIN APTEROUS sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;neurogenesis#GO:0022008;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;system development#GO:0048731;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;regulation of macromolecule biosynthetic process#GO:0010556;generation of neurons#GO:0048699;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG185570|UniProtKB=T1FMZ6 T1FMZ6 20210195 PTHR10677:SF3 UBIQUILIN FI07626P-RELATED protein binding#GO:0005515;binding#GO:0005488;polyubiquitin modification-dependent protein binding#GO:0031593;modification-dependent protein binding#GO:0140030 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG153971|UniProtKB=T1ELD3 T1ELD3 20197383 PTHR16255:SF1 REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG HELRO|EnsemblGenome=HelroG188158|UniProtKB=T1FPQ1 T1FPQ1 20210798 PTHR46659:SF1 SERINE/THREONINE/TYROSINE-INTERACTING-LIKE PROTEIN 1 SERINE_THREONINE_TYROSINE-INTERACTING-LIKE PROTEIN 1 phosphatase binding#GO:0019902;phosphatase regulator activity#GO:0019208;binding#GO:0005488;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888;enzyme binding#GO:0019899;protein binding#GO:0005515;phosphatase inhibitor activity#GO:0019212;enzyme inhibitor activity#GO:0004857;protein phosphatase binding#GO:0019903;protein phosphatase inhibitor activity#GO:0004864;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 positive regulation of apoptotic process#GO:0043065;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of apoptotic process#GO:0042981;positive regulation of signal transduction#GO:0009967;regulation of organelle organization#GO:0033043;regulation of signaling#GO:0023051;regulation of cellular component organization#GO:0051128;regulation of apoptotic signaling pathway#GO:2001233;regulation of intracellular signal transduction#GO:1902531;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;positive regulation of response to stimulus#GO:0048584;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;negative regulation of organelle organization#GO:0010639;regulation of organelle assembly#GO:1902115;regulation of signal transduction#GO:0009966;positive regulation of cell communication#GO:0010647;biological regulation#GO:0065007;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of apoptotic signaling pathway#GO:2001235;negative regulation of cellular component organization#GO:0051129;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;regulation of intrinsic apoptotic signaling pathway#GO:2001242;regulation of programmed cell death#GO:0043067 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG88194|UniProtKB=T1G6Z6 T1G6Z6 20216843 PTHR45771:SF6 HOMEOTIC PROTEIN DEFORMED HOMEOTIC PROTEIN SEX COMBS REDUCED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;pattern specification process#GO:0007389;positive regulation of biological process#GO:0048518;regulation of DNA-templated transcription#GO:0006355;multicellular organism development#GO:0007275;regionalization#GO:0003002;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;anatomical structure development#GO:0048856;biological regulation#GO:0065007;anterior/posterior pattern specification#GO:0009952;multicellular organismal process#GO:0032501;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG189915|UniProtKB=T1FRH4 T1FRH4 20211421 PTHR15136:SF5 STROMAL INTERACTION MOLECULE HOMOLOG STROMAL INTERACTION MOLECULE HOMOLOG cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;molecular function regulator activity#GO:0098772;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;transporter regulator activity#GO:0141108;channel regulator activity#GO:0016247;ion binding#GO:0043167 inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;regulation of metal ion transport#GO:0010959;transport#GO:0006810;positive regulation of molecular function#GO:0044093;positive regulation of cation channel activity#GO:2001259;regulation of localization#GO:0032879;regulation of monoatomic cation transmembrane transport#GO:1904062;cellular homeostasis#GO:0019725;intracellular calcium ion homeostasis#GO:0006874;calcium ion transport#GO:0006816;regulation of biological process#GO:0050789;regulation of transport#GO:0051049;establishment of localization#GO:0051234;regulation of molecular function#GO:0065009;monoatomic cation transport#GO:0006812;regulation of monoatomic ion transmembrane transporter activity#GO:0032412;regulation of transmembrane transporter activity#GO:0022898;regulation of monoatomic ion transport#GO:0043269;regulation of transporter activity#GO:0032409;positive regulation of biological process#GO:0048518;regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;metal ion transport#GO:0030001;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;regulation of calcium ion transport#GO:0051924;positive regulation of transport#GO:0051050;intracellular chemical homeostasis#GO:0055082;chemical homeostasis#GO:0048878;monoatomic ion homeostasis#GO:0050801;positive regulation of cellular process#GO:0048522;localization#GO:0051179;positive regulation of transporter activity#GO:0032411;regulation of cellular process#GO:0050794;intracellular monoatomic cation homeostasis#GO:0030003;biological regulation#GO:0065007;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG186257|UniProtKB=T1FNV7 T1FNV7 20210504 PTHR10803:SF3 ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE ATPASE GET3 pyrophosphatase activity#GO:0016462;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 transporter#PC00227 HELRO|EnsemblGenome=HelroG188177|UniProtKB=T1FPQ8 T1FPQ8 20210805 PTHR44186:SF1 FAMILY NOT NAMED BARDET-BIEDL SYNDROME 4 PROTEIN HELRO|EnsemblGenome=HelroG66762|UniProtKB=T1FYQ5 T1FYQ5 20213953 PTHR47977:SF90 RAS-RELATED PROTEIN RAB RAS AND EF-HAND DOMAIN-CONTAINING PROTEIN HOMOLOG GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;transport#GO:0006810 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG161920|UniProtKB=T1ES16 T1ES16 20199366 PTHR38537:SF13 JITTERBUG, ISOFORM N JITTERBUG, ISOFORM N HELRO|EnsemblGenome=HelroG64159|UniProtKB=T1FXQ4 T1FXQ4 20213602 PTHR24235:SF29 NEUROPEPTIDE Y RECEPTOR GH23382P G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG157115|UniProtKB=T1EM63 T1EM63 20197663 PTHR19143:SF459 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG177225|UniProtKB=T1FBD6 T1FBD6 20206135 PTHR43903:SF28 NEUROLIGIN NEUROLIGIN 3, ISOFORM B cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG64670|UniProtKB=T1FXX8 T1FXX8 20213676 PTHR15601:SF0 STRESS ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN SERP1/RAMP4 GEO09675P1 response to organic substance#GO:0010033;signal transduction#GO:0007165;endoplasmic reticulum unfolded protein response#GO:0030968;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;cellular response to chemical stimulus#GO:0070887;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to topologically incorrect protein#GO:0035967;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;response to topologically incorrect protein#GO:0035966;response to unfolded protein#GO:0006986;cellular response to unfolded protein#GO:0034620;biological regulation#GO:0065007;cellular response to stress#GO:0033554;signaling#GO:0023052 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG141392|UniProtKB=T1EJ34 T1EJ34 20196584 PTHR11662:SF456 SOLUTE CARRIER FAMILY 17 VESICULAR GLUTAMATE TRANSPORTER, ISOFORM A secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG72262|UniProtKB=T1G0X6 T1G0X6 20214724 PTHR13082:SF0 SAP18 HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18 molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;protein binding#GO:0005515;transcription factor binding#GO:0008134 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 Hedgehog signaling pathway#P00025>Sap18#P00697 HELRO|EnsemblGenome=HelroG96716|UniProtKB=T1G9D4 T1G9D4 20217681 PTHR22762:SF131 ALPHA-GLUCOSIDASE GLYCOSIDE HYDROLASE FAMILY 31 N-TERMINAL DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;glucosidase activity#GO:0015926;hydrolase activity, acting on glycosyl bonds#GO:0016798;alpha-glucosidase activity#GO:0090599;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 glucosidase#PC00108;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG172621|UniProtKB=T1F5N2 T1F5N2 20204131 PTHR18952:SF141 CARBONIC ANHYDRASE CARBONIC ANHYDRASE carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG96051|UniProtKB=T1G999 T1G999 20217646 PTHR22950:SF349 AMINO ACID TRANSPORTER AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN L-amino acid transmembrane transporter activity#GO:0015179;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171;organic anion transmembrane transporter activity#GO:0008514;organic acid transmembrane transporter activity#GO:0005342;transporter activity#GO:0005215 localization#GO:0051179;organic substance transport#GO:0071702;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;organic anion transport#GO:0015711;amino acid transport#GO:0006865;organic acid transport#GO:0015849;transport#GO:0006810;nitrogen compound transport#GO:0071705;organic acid transmembrane transport#GO:1903825;carboxylic acid transport#GO:0046942;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuolar membrane#GO:0005774;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 amino acid transporter#PC00046;transporter#PC00227 HELRO|EnsemblGenome=HelroG161570|UniProtKB=T1ERM6 T1ERM6 20199226 PTHR13327:SF0 NADH-UBIQUINONE OXIDOREDUCTASE ESSS SUBUNIT, MITOCHONDRIAL PRECURSOR NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 11, MITOCHONDRIAL envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transporter complex#GO:1990351;oxidoreductase complex#GO:1990204;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;respirasome#GO:0070469;mitochondrial respiratory chain complex I#GO:0005747;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;transmembrane transporter complex#GO:1902495;mitochondrial respirasome#GO:0005746;membrane-bounded organelle#GO:0043227;respiratory chain complex I#GO:0045271;NADH dehydrogenase complex#GO:0030964;mitochondrial protein-containing complex#GO:0098798 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG165532|UniProtKB=T1EWZ1 T1EWZ1 20201091 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG181976|UniProtKB=T1FHK0 T1FHK0 20208299 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED FMRFAMIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG75405|UniProtKB=T1G247 T1G247 20215145 PTHR43078:SF6 UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED UDP-GLUCURONIC ACID DECARBOXYLASE 1 nucleotide binding#GO:0000166;carboxy-lyase activity#GO:0016831;carbon-carbon lyase activity#GO:0016830;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;lyase activity#GO:0016829;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 decarboxylase#PC00089;lyase#PC00144 HELRO|EnsemblGenome=HelroG185441|UniProtKB=T1FMU0 T1FMU0 20210139 PTHR23075:SF0 PUTATIVE ATP-ASE ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 3 cation binding#GO:0043169;metal ion binding#GO:0046872;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;zinc ion binding#GO:0008270;transition metal ion binding#GO:0046914 cellular component organization or biogenesis#GO:0071840;mitochondrion organization#GO:0007005;cellular component organization#GO:0016043;cellular process#GO:0009987;organelle organization#GO:0006996 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG78899|UniProtKB=T1G3H1 T1G3H1 20215619 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;heme binding#GO:0020037 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG150062|UniProtKB=T1EKE2 T1EKE2 20197042 PTHR15362:SF7 PHOSPHATIDYLINOSITOL SYNTHASE PHOSPHATIDYLSERINE SYNTHASE 2 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG76173|UniProtKB=T1G2G2 T1G2G2 20215260 PTHR22779:SF6 SD17342P SD17342P HELRO|EnsemblGenome=HelroG180780|UniProtKB=T1FG97 T1FG97 20207846 PTHR31797:SF6 EXTRACELLULAR MATRIX PROTEIN A-RELATED CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG69385|UniProtKB=T1FZU4 T1FZU4 20214342 PTHR45877:SF2 E3 UBIQUITIN-PROTEIN LIGASE SIAH2 E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Wnt signaling pathway#P00057>SIAH-1#P01433 HELRO|EnsemblGenome=HelroG190714|UniProtKB=T1FS81 T1FS81 20211678 PTHR14732:SF0 RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG161777|UniProtKB=T1ERW6 T1ERW6 20199316 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG121592|UniProtKB=T1EGS5 T1EGS5 20195775 PTHR24238:SF66 G-PROTEIN COUPLED RECEPTOR TACHYKININ-LIKE PEPTIDES RECEPTOR 86C signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;neuropeptide signaling pathway#GO:0007218;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG162754|UniProtKB=T1ET32 T1ET32 20199732 PTHR13211:SF0 TELOMERASE CAJAL BODY PROTEIN 1 TELOMERASE CAJAL BODY PROTEIN 1 HELRO|EnsemblGenome=HelroG175473|UniProtKB=T1F9A5 T1F9A5 20205404 PTHR44170:SF56 PROTEIN SIDEKICK FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG194454|UniProtKB=T1FW26 T1FW26 20213022 PTHR43612:SF3 TRIFUNCTIONAL ENZYME SUBUNIT ALPHA TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;lipid oxidation#GO:0034440;cellular metabolic process#GO:0044237;lipid catabolic process#GO:0016042;lipid modification#GO:0030258;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;fatty acid catabolic process#GO:0009062;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;fatty acid metabolic process#GO:0006631;small molecule catabolic process#GO:0044282;fatty acid beta-oxidation#GO:0006635;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;carboxylic acid metabolic process#GO:0019752;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329 HELRO|EnsemblGenome=HelroG73357|UniProtKB=T1G1D1 T1G1D1 20214879 PTHR48032:SF18 RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6 RRM DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG183352|UniProtKB=T1FJI0 T1FJI0 20208979 PTHR46954:SF1 C2H2-TYPE DOMAIN-CONTAINING PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG146726|UniProtKB=T1EJU0 T1EJU0 20196840 PTHR23147:SF189 SERINE/ARGININE RICH SPLICING FACTOR SERINE AND ARGININE-RICH-SPLICING FACTOR 3A nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;nuclear speck#GO:0016607;organelle#GO:0043226;nuclear body#GO:0016604;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG167198|UniProtKB=T1EZ48 T1EZ48 20201848 PTHR47537:SF2 CUBILIN CUBILIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG109215|UniProtKB=T1EER4 T1EER4 20195066 PTHR12280:SF20 PANTOTHENATE KINASE 4'-PHOSPHOPANTETHEINE PHOSPHATASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 kinase#PC00137 Coenzyme A biosynthesis#P02736>Pantothenate kinase#P02885 HELRO|EnsemblGenome=HelroG193432|UniProtKB=T1FUZ3 T1FUZ3 20212639 PTHR12830:SF9 ANAPHASE-PROMOTING COMPLEX SUBUNIT 5 ANAPHASE-PROMOTING COMPLEX SUBUNIT 5 regulation of mitotic nuclear division#GO:0007088;regulation of chromosome segregation#GO:0051983;positive regulation of organelle organization#GO:0010638;macromolecule modification#GO:0043412;regulation of chromosome separation#GO:1905818;protein catabolic process#GO:0030163;organonitrogen compound catabolic process#GO:1901565;protein modification process#GO:0036211;regulation of cellular component organization#GO:0051128;positive regulation of cell cycle#GO:0045787;post-translational protein modification#GO:0043687;modification-dependent macromolecule catabolic process#GO:0043632;regulation of biological process#GO:0050789;nitrogen compound metabolic process#GO:0006807;positive regulation of cell cycle process#GO:0090068;positive regulation of mitotic cell cycle#GO:0045931;proteolysis#GO:0006508;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein K11-linked ubiquitination#GO:0070979;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;positive regulation of biological process#GO:0048518;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;regulation of chromosome organization#GO:0033044;macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;regulation of mitotic sister chromatid separation#GO:0010965;regulation of nuclear division#GO:0051783;protein modification by small protein conjugation or removal#GO:0070647;regulation of mitotic cell cycle phase transition#GO:1901990;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of organelle organization#GO:0033043;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;regulation of cell cycle phase transition#GO:1901987;positive regulation of mitotic nuclear division#GO:0045840;organonitrogen compound metabolic process#GO:1901564;regulation of mitotic metaphase/anaphase transition#GO:0030071;primary metabolic process#GO:0044238;regulation of cell cycle process#GO:0010564;positive regulation of cellular process#GO:0048522;ubiquitin-dependent protein catabolic process#GO:0006511;anaphase-promoting complex-dependent catabolic process#GO:0031145;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;regulation of cell cycle#GO:0051726;regulation of sister chromatid segregation#GO:0033045;regulation of mitotic cell cycle#GO:0007346 ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234;anaphase-promoting complex#GO:0005680;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG169912|UniProtKB=T1F2F8 T1F2F8 20203008 PTHR22776:SF49 MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN MARVEL DOMAIN-CONTAINING PROTEIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG65080|UniProtKB=T1FY30 T1FY30 20213728 PTHR12245:SF7 SPRY DOMAIN CONTAINING SOCS BOX PROTEIN F-BOX_SPRY DOMAIN-CONTAINING PROTEIN 1 cellular component biogenesis#GO:0044085;developmental process#GO:0032502;protein catabolic process#GO:0030163;organonitrogen compound catabolic process#GO:1901565;nervous system development#GO:0007399;modification-dependent macromolecule catabolic process#GO:0043632;system development#GO:0048731;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;cell junction assembly#GO:0034329;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular component assembly#GO:0022607;modification-dependent protein catabolic process#GO:0019941;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;multicellular organism development#GO:0007275;organonitrogen compound metabolic process#GO:1901564;cellular component organization#GO:0016043;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;synapse organization#GO:0050808;synapse assembly#GO:0007416;anatomical structure development#GO:0048856;cell junction organization#GO:0034330;multicellular organismal process#GO:0032501 SCF ubiquitin ligase complex#GO:0019005;synapse#GO:0045202;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234;cell junction#GO:0030054;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG111413|UniProtKB=T1EFB1 T1EFB1 20195263 PTHR14898:SF0 ENHANCER OF POLYCOMB ENHANCER OF POLYCOMB-LIKE PROTEIN regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG107427|UniProtKB=T1EEA4 T1EEA4 20194906 PTHR10858:SF23 DEOXYRIBONUCLEASE II DEOXYRIBONUCLEASE II hydrolase activity, acting on ester bonds#GO:0016788;DNA endonuclease activity#GO:0004520;nuclease activity#GO:0004518;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;execution phase of apoptosis#GO:0097194;heterocycle catabolic process#GO:0046700;macromolecule metabolic process#GO:0043170;DNA catabolic process#GO:0006308;cellular metabolic process#GO:0044237;programmed cell death#GO:0012501;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular nitrogen compound catabolic process#GO:0044270;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;cellular component disassembly#GO:0022411;aromatic compound catabolic process#GO:0019439;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;apoptotic process#GO:0006915;cell death#GO:0008219;organic cyclic compound catabolic process#GO:1901361;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;nucleobase-containing compound catabolic process#GO:0034655;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;cellular catabolic process#GO:0044248 endodeoxyribonuclease#PC00093 HELRO|EnsemblGenome=HelroG62694|UniProtKB=T1FX37 T1FX37 20213385 PTHR24637:SF388 COLLAGEN NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG83478|UniProtKB=T1G560 T1G560 20216208 PTHR12027:SF98 WNT RELATED PROTEIN WNT molecular function activator activity#GO:0140677;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;protein binding#GO:0005515;cytokine activity#GO:0005125;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;neurogenesis#GO:0022008;developmental process#GO:0032502;multicellular organism development#GO:0007275;cell communication#GO:0007154;cell fate commitment#GO:0045165;cell-cell signaling by wnt#GO:0198738;nervous system development#GO:0007399;cellular process#GO:0009987;regulation of biological process#GO:0050789;system development#GO:0048731;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;cell-cell signaling#GO:0007267;signaling#GO:0023052;canonical Wnt signaling pathway#GO:0060070;Wnt signaling pathway#GO:0016055 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG70386|UniProtKB=T1G060 T1G060 20214458 PTHR12619:SF33 RFX TRANSCRIPTION FACTOR FAMILY RFX, ISOFORM H sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG171375|UniProtKB=T1F472 T1F472 20203621 PTHR24180:SF45 CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED POLY [ADP-RIBOSE] POLYMERASE TANKYRASE kinase inhibitor#PC00139 HELRO|EnsemblGenome=HelroG166695|UniProtKB=T1EYD6 T1EYD6 20201586 PTHR15863:SF2 MRN COMPLEX-INTERACTING PROTEIN MRN COMPLEX-INTERACTING PROTEIN protein-containing complex binding#GO:0044877;binding#GO:0005488;chromatin binding#GO:0003682 signal transduction#GO:0007165;negative regulation of biological process#GO:0048519;DNA damage checkpoint signaling#GO:0000077;mitotic cell cycle checkpoint signaling#GO:0007093;cell cycle process#GO:0022402;negative regulation of cell cycle process#GO:0010948;mitotic cell cycle process#GO:1903047;regulation of biological process#GO:0050789;cell cycle checkpoint signaling#GO:0000075;negative regulation of mitotic cell cycle phase transition#GO:1901991;DNA damage response#GO:0006974;mitotic cell cycle#GO:0000278;signal transduction in response to DNA damage#GO:0042770;intracellular signal transduction#GO:0035556;signaling#GO:0023052;negative regulation of cellular process#GO:0048523;cellular response to stimulus#GO:0051716;regulation of cell cycle G2/M phase transition#GO:1902749;negative regulation of cell cycle G2/M phase transition#GO:1902750;negative regulation of cell cycle#GO:0045786;regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of cell cycle phase transition#GO:1901988;regulation of cell cycle phase transition#GO:1901987;negative regulation of mitotic cell cycle#GO:0045930;cell communication#GO:0007154;cellular process#GO:0009987;regulation of cell cycle process#GO:0010564;response to stimulus#GO:0050896;DNA integrity checkpoint signaling#GO:0031570;response to stress#GO:0006950;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;regulation of cellular process#GO:0050794;mitotic G2/M transition checkpoint#GO:0044818;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;mitotic DNA integrity checkpoint signaling#GO:0044774;regulation of G2/M transition of mitotic cell cycle#GO:0010389;mitotic G2 DNA damage checkpoint signaling#GO:0007095;cellular response to stress#GO:0033554;regulation of mitotic cell cycle#GO:0007346;mitotic DNA damage checkpoint signaling#GO:0044773 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG82735|UniProtKB=T1G4V9 T1G4V9 20216107 PTHR15741:SF37 BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR LD38259P sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG74476|UniProtKB=T1G1R7 T1G1R7 20215015 PTHR12970:SF1 PROTEASOME ASSEMBLY CHAPERONE 2 PROTEASOME ASSEMBLY CHAPERONE 2 protein-containing complex assembly#GO:0065003;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cellular process#GO:0009987;protein-containing complex organization#GO:0043933 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG186112|UniProtKB=T1FNN7 T1FNN7 20210434 PTHR13375:SF3 FMS INTERACTING PROTEIN THO COMPLEX SUBUNIT 5 HOMOLOG nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;mRNA transport#GO:0051028;RNA localization#GO:0006403;localization#GO:0051179;organic substance transport#GO:0071702;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;THO complex#GO:0000347;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;transcription export complex#GO:0000346;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG159488|UniProtKB=T1EP33 T1EP33 20198333 PTHR47027:SF20 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN HELRO|EnsemblGenome=HelroG169974|UniProtKB=T1F2H9 T1F2H9 20203029 PTHR23113:SF99 GUANINE NUCLEOTIDE EXCHANGE FACTOR RASGEF DOMAIN-CONTAINING PROTEIN guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG161326|UniProtKB=T1ERC5 T1ERC5 20199125 PTHR11388:SF142 ORGANIC ANION TRANSPORTER SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 5A1 secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;organic substance transport#GO:0071702;establishment of localization#GO:0051234;organic anion transport#GO:0015711;transport#GO:0006810 basal plasma membrane#GO:0009925;basolateral plasma membrane#GO:0016323;plasma membrane region#GO:0098590;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;basal part of cell#GO:0045178;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG193616|UniProtKB=T1FV66 T1FV66 20212712 PTHR42884:SF14 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED NEUROENDOCRINE CONVERTASE 1 hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;membrane#GO:0016020 serine protease#PC00203;protein modifying enzyme#PC00260 Endothelin signaling pathway#P00019>furin#P00575;Alzheimer disease-presenilin pathway#P00004>Furin#P00157;Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105 HELRO|EnsemblGenome=HelroG178754|UniProtKB=T1FDP0 T1FDP0 20206939 PTHR47148:SF1 CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1 HOMOLOG CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1 HOMOLOG cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;respiratory chain complex IV assembly#GO:0008535;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrial respiratory chain complex I assembly#GO:0032981;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;cytochrome complex assembly#GO:0017004;protein-containing complex assembly#GO:0065003;mitochondrial cytochrome c oxidase assembly#GO:0033617;mitochondrion organization#GO:0007005;cellular component organization#GO:0016043;cellular process#GO:0009987 envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227 chaperone#PC00072 HELRO|EnsemblGenome=HelroG115556|UniProtKB=T1EG92 T1EG92 20195594 PTHR12673:SF241 FACIOGENITAL DYSPLASIA PROTEIN DH DOMAIN-CONTAINING PROTEIN nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cell projection organization#GO:0030030;organelle organization#GO:0006996;filopodium assembly#GO:0046847;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG193528|UniProtKB=T1FV32 T1FV32 20212678 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG127646|UniProtKB=T1EHG2 T1EHG2 20196012 PTHR11849:SF182 ETS SAM POINTED DOMAIN-CONTAINING ETS TRANSCRIPTION FACTOR transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 PDGF signaling pathway#P00047>Ets#P01167 HELRO|EnsemblGenome=HelroG163813|UniProtKB=T1EUI1 T1EUI1 20200231 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG68387|UniProtKB=T1FZD8 T1FZD8 20214186 PTHR21635:SF0 LEUCINE ZIPPER TRANSCRIPTION FACTOR LIKE LEUCINE ZIPPER TRANSCRIPTION FACTOR-LIKE PROTEIN 1 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of localization#GO:0032879;regulation of cellular localization#GO:0060341;negative regulation of cellular process#GO:0048523;regulation of protein localization#GO:0032880 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;basic leucine zipper transcription factor#PC00056 HELRO|EnsemblGenome=HelroG105497|UniProtKB=T1EDV8 T1EDV8 20194760 PTHR19443:SF16 HEXOKINASE HEXOKINASE TYPE 1-RELATED transferase activity, transferring phosphorus-containing groups#GO:0016772;carbohydrate kinase activity#GO:0019200;transferase activity#GO:0016740;hexokinase activity#GO:0004396;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 monosaccharide metabolic process#GO:0005996;carbohydrate phosphorylation#GO:0046835;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;hexose metabolic process#GO:0019318;cellular process#GO:0009987;carbohydrate metabolic process#GO:0005975;glucose metabolic process#GO:0006006;phosphorus metabolic process#GO:0006793;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704 kinase#PC00137 Pentose phosphate pathway#P02762>Hexokinase#P03079;Glycolysis#P00024>Hexokinase#P00677;Fructose galactose metabolism#P02744>Hexokinase#P02966 HELRO|EnsemblGenome=HelroG162533|UniProtKB=T1EST2 T1EST2 20199632 PTHR16095:SF11 TRANSMEMBRANE PROTEIN 143 FAMILY MEMBER TRANSMEMBRANE PROTEIN 143 HELRO|EnsemblGenome=HelroG185904|UniProtKB=T1FNF2 T1FNF2 20210349 PTHR45832:SF22 SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED HELRO|EnsemblGenome=HelroG70492|UniProtKB=T1G071 T1G071 20214469 PTHR11414:SF21 CYSTATIN FAMILY MEMBER CYSTATIN 14A, TANDEM DUPLICATE 1-RELATED protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG77913|UniProtKB=T1G354 T1G354 20215502 PTHR45787:SF1 LD11652P LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;protein binding#GO:0005515;transcription factor binding#GO:0008134;DNA-binding transcription factor binding#GO:0140297 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG88258|UniProtKB=T1G708 T1G708 20216855 PTHR14519:SF5 VITAMIN K EPOXIDE REDUCTASE COMPLEX, SUBUNIT 1 VITAMIN K EPOXIDE REDUCTASE COMPLEX SUBUNIT 1-LIKE PROTEIN 1 catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cellular process#GO:0009987;protein metabolic process#GO:0019538;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG179864|UniProtKB=T1FF79 T1FF79 20207478 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG159812|UniProtKB=T1EPF3 T1EPF3 20198453 PTHR45632:SF17 LD33804P KELCH-LIKE PROTEIN 31 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG68763|UniProtKB=T1FZJ4 T1FZJ4 20214242 PTHR11842:SF11 MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2 MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A negative regulation of sister chromatid segregation#GO:0033046;negative regulation of mitotic sister chromatid separation#GO:2000816;negative regulation of biological process#GO:0048519;regulation of mitotic nuclear division#GO:0007088;signal transduction#GO:0007165;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;regulation of chromosome segregation#GO:0051983;mitotic cell cycle checkpoint signaling#GO:0007093;negative regulation of chromosome organization#GO:2001251;regulation of chromosome separation#GO:1905818;negative regulation of mitotic nuclear division#GO:0045839;cell cycle process#GO:0022402;regulation of cellular component organization#GO:0051128;negative regulation of cell cycle process#GO:0010948;negative regulation of nuclear division#GO:0051784;negative regulation of mitotic sister chromatid segregation#GO:0033048;mitotic cell cycle process#GO:1903047;regulation of biological process#GO:0050789;cell cycle checkpoint signaling#GO:0000075;negative regulation of mitotic cell cycle phase transition#GO:1901991;mitotic cell cycle#GO:0000278;negative regulation of organelle organization#GO:0010639;regulation of mitotic sister chromatid segregation#GO:0033047;intracellular signal transduction#GO:0035556;negative regulation of cellular component organization#GO:0051129;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;regulation of chromosome organization#GO:0033044;cellular response to stimulus#GO:0051716;regulation of mitotic sister chromatid separation#GO:0010965;regulation of nuclear division#GO:0051783;regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of cell cycle#GO:0045786;regulation of organelle organization#GO:0033043;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;mitotic spindle assembly checkpoint signaling#GO:0007094;negative regulation of chromosome segregation#GO:0051985;regulation of cell cycle phase transition#GO:1901987;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of mitotic cell cycle#GO:0045930;cell communication#GO:0007154;cellular process#GO:0009987;regulation of mitotic metaphase/anaphase transition#GO:0030071;regulation of cell cycle process#GO:0010564;response to stimulus#GO:0050896;negative regulation of chromosome separation#GO:1905819;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of sister chromatid segregation#GO:0033045;regulation of mitotic cell cycle#GO:0007346;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100 membrane-enclosed lumen#GO:0031974;supramolecular complex#GO:0099080;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;kinetochore#GO:0000776;nucleoplasm#GO:0005654;condensed chromosome, centromeric region#GO:0000779;condensed chromosome#GO:0000793;intracellular organelle lumen#GO:0070013;chromosome, centromeric region#GO:0000775;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;chromosomal region#GO:0098687;nuclear lumen#GO:0031981 HELRO|EnsemblGenome=HelroG192551|UniProtKB=T1FU25 T1FU25 20212321 PTHR44147:SF2 DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 1 DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 1 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG185119|UniProtKB=T1FMF2 T1FMF2 20210001 PTHR18884:SF126 SEPTIN SEPTIN-7 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 localization#GO:0051179;cell division#GO:0051301;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;cytoskeleton-dependent cytokinesis#GO:0061640;cell cycle process#GO:0022402;cell cycle#GO:0007049;cellular process#GO:0009987;cytokinesis#GO:0000910;protein localization#GO:0008104 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;cell division site#GO:0032153;cell cortex#GO:0005938;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG88955|UniProtKB=T1G776 T1G776 20216923 PTHR24351:SF249 RIBOSOMAL PROTEIN S6 KINASE PROTEIN KINASE C transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG176620|UniProtKB=T1FAQ8 T1FAQ8 20205907 PTHR10913:SF45 FOLLISTATIN-RELATED FOLLISTATIN, ISOFORM A-RELATED cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG109256|UniProtKB=T1EES0 T1EES0 20195072 PTHR11469:SF1 GLUCOSE-6-PHOSPHATE ISOMERASE GLUCOSE-6-PHOSPHATE ISOMERASE carbohydrate binding#GO:0030246;isomerase activity#GO:0016853;small molecule binding#GO:0036094;monosaccharide binding#GO:0048029;binding#GO:0005488;catalytic activity#GO:0003824 ribonucleoside triphosphate metabolic process#GO:0009199;nucleoside triphosphate metabolic process#GO:0009141;heterocycle catabolic process#GO:0046700;ribonucleotide catabolic process#GO:0009261;pyridine nucleotide metabolic process#GO:0019362;nucleobase-containing compound metabolic process#GO:0006139;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;purine ribonucleotide catabolic process#GO:0009154;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;oxoacid metabolic process#GO:0043436;nucleoside phosphate catabolic process#GO:1901292;carbohydrate derivative catabolic process#GO:1901136;purine ribonucleoside triphosphate metabolic process#GO:0009205;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;nucleotide catabolic process#GO:0009166;cellular nitrogen compound metabolic process#GO:0034641;nicotinamide nucleotide metabolic process#GO:0046496;nucleoside diphosphate catabolic process#GO:0009134;organic acid metabolic process#GO:0006082;ribonucleotide metabolic process#GO:0009259;monocarboxylic acid metabolic process#GO:0032787;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;glucose 6-phosphate metabolic process#GO:0051156;organophosphate catabolic process#GO:0046434;hexose biosynthetic process#GO:0019319;glycolytic process#GO:0006096;organophosphate metabolic process#GO:0019637;small molecule biosynthetic process#GO:0044283;nucleobase-containing compound catabolic process#GO:0034655;nucleotide metabolic process#GO:0009117;small molecule metabolic process#GO:0044281;cellular aromatic compound metabolic process#GO:0006725;monosaccharide metabolic process#GO:0005996;carbohydrate derivative metabolic process#GO:1901135;organonitrogen compound catabolic process#GO:1901565;biosynthetic process#GO:0009058;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;purine-containing compound catabolic process#GO:0072523;cellular nitrogen compound catabolic process#GO:0044270;purine nucleotide catabolic process#GO:0006195;organic cyclic compound metabolic process#GO:1901360;carbohydrate catabolic process#GO:0016052;catabolic process#GO:0009056;nucleoside diphosphate metabolic process#GO:0009132;organic substance catabolic process#GO:1901575;carbohydrate metabolic process#GO:0005975;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;carbohydrate biosynthetic process#GO:0016051;heterocycle metabolic process#GO:0046483;organonitrogen compound metabolic process#GO:1901564;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;glucose metabolic process#GO:0006006;aromatic compound catabolic process#GO:0019439;organic cyclic compound catabolic process#GO:1901361;purine nucleoside triphosphate metabolic process#GO:0009144;hexose metabolic process#GO:0019318;carboxylic acid metabolic process#GO:0019752;nucleobase-containing small molecule metabolic process#GO:0055086 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 isomerase#PC00135;metabolite interconversion enzyme#PC00262 Pentose phosphate pathway#P02762>Glucose-P-Isomerase#P03080;Glycolysis#P00024>Phosphoglucose isomerase#P00674 HELRO|EnsemblGenome=HelroG117195|UniProtKB=T1EGK9 T1EGK9 20195709 PTHR12786:SF1 SPLICING FACTOR SF3A-RELATED SPLICING REGULATOR SDE2 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG87059|UniProtKB=T1G6L2 T1G6L2 20216709 PTHR42943:SF2 GLUTATHIONE S-TRANSFERASE KAPPA GLUTATHIONE S-TRANSFERASE KAPPA 1 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG84379|UniProtKB=T1G5I1 T1G5I1 20216328 PTHR23423:SF17 ORGANIC SOLUTE TRANSPORTER-RELATED IP17403P localization#GO:0051179;establishment of localization#GO:0051234;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG187311|UniProtKB=T1FP86 T1FP86 20210633 PTHR19960:SF11 TEKTIN TEKTIN cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cilium or flagellum-dependent cell motility#GO:0001539;cell motility#GO:0048870;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;cilium movement involved in cell motility#GO:0060294;cilium movement#GO:0003341;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cilium-dependent cell motility#GO:0060285;microtubule-based process#GO:0007017;organelle organization#GO:0006996;plasma membrane bounded cell projection assembly#GO:0120031 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG76547|UniProtKB=T1G2L3 T1G2L3 20215311 PTHR18945:SF865 NEUROTRANSMITTER GATED ION CHANNEL NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA7, ISOFORM E ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG181592|UniProtKB=T1FH51 T1FH51 20208150 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG191322|UniProtKB=T1FSV8 T1FSV8 20211905 PTHR22880:SF225 FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED protein binding#GO:0005515;histone binding#GO:0042393;binding#GO:0005488;modification-dependent protein binding#GO:0140030 protein-DNA complex organization#GO:0071824;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;cellular component organization#GO:0016043;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG70258|UniProtKB=T1G039 T1G039 20214437 PTHR24418:SF418 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE FER protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG183366|UniProtKB=T1FJI6 T1FJI6 20208985 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;heme binding#GO:0020037 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG162885|UniProtKB=T1ETB5 T1ETB5 20199815 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG104410|UniProtKB=T1EDL5 T1EDL5 20194667 PTHR47958:SF31 ATP-DEPENDENT RNA HELICASE DBP3 RNA HELICASE catalytic activity, acting on RNA#GO:0140098;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640;mRNA binding#GO:0003729 poly(A)+ mRNA export from nucleus#GO:0016973;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;mRNA transport#GO:0051028;RNA localization#GO:0006403;localization#GO:0051179;organic substance transport#GO:0071702;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytoplasmic stress granule#GO:0010494;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG191041|UniProtKB=T1FSJ2 T1FSJ2 20211789 PTHR12738:SF0 NEUROENDOCRINE PROTEIN 7B2 NEUROENDOCRINE PROTEIN 7B2 molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of transport#GO:0051049;regulation of biological quality#GO:0065008;regulation of secretion#GO:0051046;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;regulation of hormone secretion#GO:0046883;biological regulation#GO:0065007;regulation of secretion by cell#GO:1903530;regulation of localization#GO:0032879;regulation of hormone levels#GO:0010817 chaperone#PC00072 HELRO|EnsemblGenome=HelroG181419|UniProtKB=T1FGZ6 T1FGZ6 20208095 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG167079|UniProtKB=T1EYZ8 T1EYZ8 20201798 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG151232|UniProtKB=T1EKJ1 T1EKJ1 20197091 PTHR14057:SF47 TRANSCRIPTION FACTOR ONECUT HOMEOBOX PROTEIN ONECUT sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG106256|UniProtKB=T1EE11 T1EE11 20194813 PTHR16214:SF3 TRANSMEMBRANE PROTEIN 260 TRANSMEMBRANE PROTEIN 260 HELRO|EnsemblGenome=HelroG181333|UniProtKB=T1FGW6 T1FGW6 20208065 PTHR12844:SF42 CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS CONNECTOR ENHANCER OF KSR PROTEIN CNK scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG178817|UniProtKB=T1FDS5 T1FDS5 20206974 PTHR11461:SF372 SERINE PROTEASE INHIBITOR, SERPIN ACCESSORY GLAND PROTEIN ACP76A-RELATED extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG166746|UniProtKB=T1EYG7 T1EYG7 20201617 PTHR47510:SF3 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG62606|UniProtKB=T1FX27 T1FX27 20213375 PTHR12245:SF11 SPRY DOMAIN CONTAINING SOCS BOX PROTEIN PROTEIN GUSTAVUS macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG188630|UniProtKB=T1FQ71 T1FQ71 20210968 PTHR46232:SF1 SMARCE1 REGULATOR OF CHROMATIN SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1 nucleosome binding#GO:0031491;nucleic acid binding#GO:0003676;chromatin DNA binding#GO:0031490;nuclear receptor binding#GO:0016922;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;transcription factor binding#GO:0008134;DNA-binding transcription factor binding#GO:0140297 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;ATPase complex#GO:1904949;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;SWI/SNF complex#GO:0016514;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG91764|UniProtKB=T1G885 T1G885 20217282 PTHR48112:SF22 HIGH MOBILITY GROUP PROTEIN DSP1 MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG160179|UniProtKB=T1EPX6 T1EPX6 20198626 PTHR45080:SF33 CONTACTIN 5 IG-LIKE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cellular component organization or biogenesis#GO:0071840;synapse organization#GO:0050808;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156;cell junction organization#GO:0034330;cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cellular process#GO:0009987 somatodendritic compartment#GO:0036477;cell body#GO:0044297;neuron projection#GO:0043005;neuronal cell body#GO:0043025;cell projection#GO:0042995;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;plasma membrane#GO:0005886;axon#GO:0030424 HELRO|EnsemblGenome=HelroG192900|UniProtKB=T1FUE4 T1FUE4 20212440 PTHR23322:SF6 FAS-ASSOCIATED PROTEIN UBX DOMAIN-CONTAINING PROTEIN 7 protein binding#GO:0005515;ubiquitin-like protein binding#GO:0032182;binding#GO:0005488;ubiquitin binding#GO:0043130 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG121825|UniProtKB=T1EGS8 T1EGS8 20195778 PTHR18952:SF282 CARBONIC ANHYDRASE CARBONIC ANHYDRASE 1 carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG89477|UniProtKB=T1G7D2 T1G7D2 20216979 PTHR11380:SF5 TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;gene expression#GO:0010467;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG168109|UniProtKB=T1F063 T1F063 20202213 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161308|UniProtKB=T1ERB6 T1ERB6 20199116 PTHR15924:SF9 CLE RNA TRANSCRIPTION, TRANSLATION AND TRANSPORT FACTOR PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;tRNA splicing, via endonucleolytic cleavage and ligation#GO:0006388;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;catalytic complex#GO:1902494 HELRO|EnsemblGenome=HelroG112224|UniProtKB=T1EFH9 T1EFH9 20195331 PTHR24418:SF373 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE SRC42A protein tyrosine kinase activity#GO:0004713;non-membrane spanning protein tyrosine kinase activity#GO:0004715;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein binding#GO:0005515;catalytic activity, acting on a protein#GO:0140096;signaling receptor binding#GO:0005102;kinase activity#GO:0016301;protein kinase activity#GO:0004672 response to external biotic stimulus#GO:0043207;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;immune response#GO:0006955;developmental process#GO:0032502;cell communication#GO:0007154;cellular process#GO:0009987;defense response to symbiont#GO:0140546;regulation of biological process#GO:0050789;immune system process#GO:0002376;response to stimulus#GO:0050896;response to external stimulus#GO:0009605;cell differentiation#GO:0030154;enzyme-linked receptor protein signaling pathway#GO:0007167;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to other organism#GO:0098542;regulation of cellular process#GO:0050794;response to other organism#GO:0051707;cell surface receptor signaling pathway#GO:0007166;biological process involved in interspecies interaction between organisms#GO:0044419;biological regulation#GO:0065007;innate immune response#GO:0045087;defense response#GO:0006952;signaling#GO:0023052;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169 non-receptor tyrosine protein kinase#PC00168 Parkinson disease#P00049>Src kinase#P01230;Integrin signalling pathway#P00034>Src#P00940 HELRO|EnsemblGenome=HelroG181889|UniProtKB=T1FHF6 T1FHF6 20208255 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG190326|UniProtKB=T1FRW9 T1FRW9 20211566 PTHR13561:SF20 DNA REPLICATION REGULATOR DPB11-RELATED DNA TOPOISOMERASE 2-BINDING PROTEIN 1 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG158856|UniProtKB=T1ENC4 T1ENC4 20198074 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172296|UniProtKB=T1F568 T1F568 20203967 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG190767|UniProtKB=T1FSA1 T1FSA1 20211698 PTHR15504:SF0 NASOPHARYNGEAL EPITHELIUM SPECIFIC PROTEIN 1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 45 HELRO|EnsemblGenome=HelroG66730|UniProtKB=T1FYP8 T1FYP8 20213946 PTHR10117:SF54 TRANSIENT RECEPTOR POTENTIAL CHANNEL TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;small molecule binding#GO:0036094;binding#GO:0005488;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;anion binding#GO:0043168;ion binding#GO:0043167;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;alcohol binding#GO:0043178 inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;regulation of cytosolic calcium ion concentration#GO:0051480;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;calcium ion transport#GO:0006816;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 Alzheimer disease-presenilin pathway#P00004>Capacitative calcium channels#P00124 HELRO|EnsemblGenome=HelroG78113|UniProtKB=T1G381 T1G381 20215529 PTHR24068:SF41 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2-24 KDA ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E2#P01491 HELRO|EnsemblGenome=HelroG174933|UniProtKB=T1F8M6 T1F8M6 20205175 PTHR24338:SF0 HOMEOBOX PROTEIN MSX MUSCLE SEGMENTATION HOMEOBOX sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;embryo development#GO:0009790;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;anatomical structure morphogenesis#GO:0009653;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;embryonic morphogenesis#GO:0048598;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG185749|UniProtKB=T1FN86 T1FN86 20210284 PTHR11774:SF6 GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA prenyltransferase activity#GO:0004659;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;protein modification process#GO:0036211;cellular process#GO:0009987;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;transferase complex#GO:1990234 acyltransferase#PC00042;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG94088|UniProtKB=T1G8Z0 T1G8Z0 20217537 PTHR13382:SF69 MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B FI18408P1 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG174042|UniProtKB=T1F7I7 T1F7I7 20204786 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG188808|UniProtKB=T1FQD8 T1FQD8 20211035 PTHR14063:SF2 PROTEIN LIN-7 HOMOLOG PROTEIN LIN-7 HOMOLOG establishment or maintenance of cell polarity#GO:0007163;cellular localization#GO:0051641;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;macromolecule localization#GO:0033036;transport#GO:0006810;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;secretion#GO:0046903;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;signal release#GO:0023061;establishment or maintenance of apical/basal cell polarity#GO:0035088;cell-cell signaling#GO:0007267;signaling#GO:0023052;secretion by cell#GO:0032940;neurotransmitter secretion#GO:0007269;localization within membrane#GO:0051668;protein localization to membrane#GO:0072657;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;protein localization#GO:0008104;protein localization to cell periphery#GO:1990778;localization#GO:0051179;cellular macromolecule localization#GO:0070727;signal release from synapse#GO:0099643;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;establishment or maintenance of bipolar cell polarity#GO:0061245;export from cell#GO:0140352 basal plasma membrane#GO:0009925;synapse#GO:0045202;anchoring junction#GO:0070161;cell-cell junction#GO:0005911;basolateral plasma membrane#GO:0016323;cell junction#GO:0030054;plasma membrane region#GO:0098590;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;basal part of cell#GO:0045178;membrane#GO:0016020;plasma membrane#GO:0005886 cell junction protein#PC00070 HELRO|EnsemblGenome=HelroG111847|UniProtKB=T1EFF0 T1EFF0 20195302 PTHR10454:SF210 CASPASE CASPASE-2 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG83215|UniProtKB=T1G522 T1G522 20216170 PTHR11711:SF31 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR-LIKE 5 G-protein#PC00020 HELRO|EnsemblGenome=HelroG184845|UniProtKB=T1FM28 T1FM28 20209877 PTHR46989:SF3 USP DOMAIN-CONTAINING PROTEIN USPA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG94890|UniProtKB=T1G937 T1G937 20217584 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-LIKE 1 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;localization#GO:0051179;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 membrane protein complex#GO:0098796;synapse#GO:0045202;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron projection#GO:0043005;transmembrane transporter complex#GO:1902495;cell projection#GO:0042995;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HELRO|EnsemblGenome=HelroG190293|UniProtKB=T1FRV4 T1FRV4 20211551 PTHR23176:SF129 RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 PDGF signaling pathway#P00047>Rho#P01174 HELRO|EnsemblGenome=HelroG84744|UniProtKB=T1G5N1 T1G5N1 20216378 PTHR22748:SF6 AP ENDONUCLEASE DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE hydrolase activity, acting on ester bonds#GO:0016788;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;3'-5'-DNA exonuclease activity#GO:0008296;nuclease activity#GO:0004518;DNA exonuclease activity#GO:0004529;catalytic activity#GO:0003824;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097;phosphoric diester hydrolase activity#GO:0008081;exonuclease activity#GO:0004527;3'-5' exonuclease activity#GO:0008408;phosphoric ester hydrolase activity#GO:0042578 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;base-excision repair#GO:0006284;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 HELRO|EnsemblGenome=HelroG84234|UniProtKB=T1G5G1 T1G5G1 20216308 PTHR12460:SF0 CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN CID DOMAIN-CONTAINING PROTEIN-RELATED basal RNA polymerase II transcription machinery binding#GO:0001099;RNA polymerase binding#GO:0070063;binding#GO:0005488;RNA polymerase core enzyme binding#GO:0043175;RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515;enzyme binding#GO:0019899;basal transcription machinery binding#GO:0001098 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;mRNA 3'-end processing#GO:0031124;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mRNA processing#GO:0006397;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 kinase modulator#PC00140;kinase inhibitor#PC00139 HELRO|EnsemblGenome=HelroG86858|UniProtKB=T1G6I4 T1G6I4 20216681 PTHR10913:SF45 FOLLISTATIN-RELATED FOLLISTATIN, ISOFORM A-RELATED cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG177589|UniProtKB=T1FBW8 T1FBW8 20206317 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG85052|UniProtKB=T1G5S3 T1G5S3 20216420 PTHR11533:SF299 PROTEASE M1 ZINC METALLOPROTEASE AMINOPEPTIDASE metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;amide binding#GO:0033218;metal ion binding#GO:0046872;peptidase activity#GO:0008233;metalloaminopeptidase activity#GO:0070006;cation binding#GO:0043169;peptide binding#GO:0042277;hydrolase activity#GO:0016787;aminopeptidase activity#GO:0004177;exopeptidase activity#GO:0008238;ion binding#GO:0043167;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;peptide catabolic process#GO:0043171;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;membrane#GO:0016020;extracellular region#GO:0005576;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG113366|UniProtKB=T1EFR8 T1EFR8 20195420 PTHR11562:SF17 CATION EFFLUX PROTEIN/ ZINC TRANSPORTER RE54080P-RELATED inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;transition metal ion transport#GO:0000041;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG157787|UniProtKB=T1EMF7 T1EMF7 20197757 PTHR43521:SF1 ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE dehydrogenase#PC00092;oxidoreductase#PC00176 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HELRO|EnsemblGenome=HelroG189231|UniProtKB=T1FQU3 T1FQU3 20211190 PTHR33768:SF3 MIP11318P MIP11318P HELRO|EnsemblGenome=HelroG162799|UniProtKB=T1ET62 T1ET62 20199762 PTHR12509:SF9 SPERMATOGENESIS-ASSOCIATED 4-RELATED SPERM FLAGELLAR PROTEIN 1 ISOFORM X1 cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 biological regulation#GO:0065007;regulation of biological process#GO:0050789;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of organelle organization#GO:0033043 axoneme#GO:0005930;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;plasma membrane bounded cell projection cytoplasm#GO:0032838;ciliary plasm#GO:0097014;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cytoskeleton#GO:0005856;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG175703|UniProtKB=T1F9J6 T1F9J6 20205495 PTHR48068:SF4 TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9 transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;RNA metabolic process#GO:0016070;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;RNA polymerase II preinitiation complex assembly#GO:0051123;transcription initiation at RNA polymerase II promoter#GO:0006367;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366 histone acetyltransferase complex#GO:0000123;DNA-directed RNA polymerase complex#GO:0000428;acetyltransferase complex#GO:1902493;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase II, holoenzyme#GO:0016591;non-membrane-bounded organelle#GO:0043228;chromosome#GO:0005694;nuclear DNA-directed RNA polymerase complex#GO:0055029;SAGA complex#GO:0000124;membrane-enclosed lumen#GO:0031974;SAGA-type complex#GO:0070461;peptidase complex#GO:1905368;organelle lumen#GO:0043233;nucleus#GO:0005634;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;protein-DNA complex#GO:0032993;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;RNA polymerase II transcription regulator complex#GO:0090575;transcription factor TFIID complex#GO:0005669;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;protein acetyltransferase complex#GO:0031248;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 General transcription regulation#P00023>TBP-associated factors#P00658;Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385 HELRO|EnsemblGenome=HelroG190506|UniProtKB=T1FS20 T1FS20 20211617 PTHR19848:SF0 WD40 REPEAT PROTEIN NOTCHLESS PROTEIN HOMOLOG 1 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;organelle assembly#GO:0070925;protein-RNA complex assembly#GO:0022618;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;ribosomal large subunit assembly#GO:0000027;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;protein-RNA complex organization#GO:0071826;non-membrane-bounded organelle assembly#GO:0140694 membrane-enclosed lumen#GO:0031974;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG159228|UniProtKB=T1ENR8 T1ENR8 20198218 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG166516|UniProtKB=T1EY72 T1EY72 20201522 PTHR10927:SF1 RIBOSOME MATURATION PROTEIN SBDS RIBOSOME MATURATION PROTEIN SBDS RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG188650|UniProtKB=T1FQ80 T1FQ80 20210977 PTHR12979:SF5 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;regulation of nitrogen compound metabolic process#GO:0051171;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;mRNA catabolic process#GO:0006402;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;organic substance catabolic process#GO:1901575;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;negative regulation of nitrogen compound metabolic process#GO:0051172;primary metabolic process#GO:0044238;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;negative regulation of translation#GO:0017148;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;regulation of translation#GO:0006417;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 CCR4-NOT complex#GO:0030014;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG170438|UniProtKB=T1F325 T1F325 20203224 PTHR45781:SF1 AGAP000281-PA HMG BOX DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;protein-containing complex binding#GO:0044877;chromatin DNA binding#GO:0031490;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG176384|UniProtKB=T1FAG8 T1FAG8 20205817 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG155886|UniProtKB=T1ELN7 T1ELN7 20197487 PTHR24006:SF823 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG70692|UniProtKB=T1G0A8 T1G0A8 20214506 PTHR13767:SF2 TRNA-PSEUDOURIDINE SYNTHASE PSEUDOURIDYLATE SYNTHASE TRUB1 isomerase activity#GO:0016853;intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;mRNA modification#GO:0016556;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;pseudouridine synthesis#GO:0001522;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 isomerase#PC00135;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG101987|UniProtKB=T1ED77 T1ED77 20194529 PTHR11566:SF212 DYNAMIN DYNAMIN GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;microtubule binding#GO:0008017;ribonucleoside triphosphate phosphatase activity#GO:0017111 localization#GO:0051179;establishment of localization#GO:0051234;receptor internalization#GO:0031623;transport#GO:0006810;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;receptor-mediated endocytosis#GO:0006898;cellular process#GO:0009987;import into cell#GO:0098657 supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cell periphery#GO:0071944;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cytoskeleton#GO:0005856;microtubule#GO:0005874;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG84318|UniProtKB=T1G5H5 T1G5H5 20216322 PTHR14094:SF9 SIGNAL RECOGNITION PARTICLE 72 SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72 ribonucleoprotein complex binding#GO:0043021;ribosome binding#GO:0043022;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;protein-containing complex binding#GO:0044877;binding#GO:0005488;organic cyclic compound binding#GO:0097159 localization within membrane#GO:0051668;cotranslational protein targeting to membrane#GO:0006613;cellular localization#GO:0051641;protein localization to endoplasmic reticulum#GO:0070972;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;protein targeting#GO:0006605;protein targeting to ER#GO:0045047;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;SRP-dependent cotranslational protein targeting to membrane#GO:0006614;establishment of protein localization to membrane#GO:0090150;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein localization to organelle#GO:0033365;establishment of protein localization to endoplasmic reticulum#GO:0072599 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG72205|UniProtKB=T1G0X1 T1G0X1 20214719 PTHR12907:SF26 EGL NINE HOMOLOG-RELATED HIF PROLYL HYDROXYLASE, ISOFORM C HELRO|EnsemblGenome=HelroG74808|UniProtKB=T1G1V9 T1G1V9 20215057 PTHR22748:SF6 AP ENDONUCLEASE DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE hydrolase activity, acting on ester bonds#GO:0016788;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;3'-5'-DNA exonuclease activity#GO:0008296;nuclease activity#GO:0004518;DNA exonuclease activity#GO:0004529;catalytic activity#GO:0003824;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097;phosphoric diester hydrolase activity#GO:0008081;exonuclease activity#GO:0004527;3'-5' exonuclease activity#GO:0008408;phosphoric ester hydrolase activity#GO:0042578 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;base-excision repair#GO:0006284;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 HELRO|EnsemblGenome=HelroG170285|UniProtKB=T1F2V7 T1F2V7 20203156 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG166947|UniProtKB=T1EYS8 T1EYS8 20201728 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190754|UniProtKB=T1FS96 T1FS96 20211693 PTHR39490:SF13 ARRESTIN DOMAIN-CONTAINING PROTEIN D FYVE-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG114213|UniProtKB=T1EG02 T1EG02 20195504 PTHR23503:SF8 SOLUTE CARRIER FAMILY 2 FACILITATED GLUCOSE TRANSPORTER PROTEIN 1 transmembrane transporter activity#GO:0022857;sugar transmembrane transporter activity#GO:0051119;transporter activity#GO:0005215;carbohydrate transmembrane transporter activity#GO:0015144 localization#GO:0051179;organic substance transport#GO:0071702;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;cellular process#GO:0009987;carbohydrate transmembrane transport#GO:0034219;carbohydrate transport#GO:0008643 cellular anatomical entity#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG184020|UniProtKB=T1FKF8 T1FKF8 20209307 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG124905|UniProtKB=T1EH34 T1EH34 20195884 PTHR21377:SF1 PROTEIN FAM210B, MITOCHONDRIAL PROTEIN FAM210A cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185726|UniProtKB=T1FN73 T1FN73 20210271 PTHR42808:SF3 HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2 HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG183641|UniProtKB=T1FJZ2 T1FJZ2 20209141 PTHR18945:SF865 NEUROTRANSMITTER GATED ION CHANNEL NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA7, ISOFORM E ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG68515|UniProtKB=T1FZG2 T1FZG2 20214210 PTHR24409:SF418 ZINC FINGER PROTEIN 142 SI:CH73-221F6.1 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG102998|UniProtKB=T1EDD5 T1EDD5 20194587 PTHR24075:SF5 SEC63 DOMAIN-CONTAINING U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE catalytic activity, acting on RNA#GO:0140098;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG72963|UniProtKB=T1G179 T1G179 20214827 PTHR12231:SF253 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG159012|UniProtKB=T1ENH4 T1ENH4 20198124 PTHR46601:SF1 ULP_PROTEASE DOMAIN-CONTAINING PROTEIN ADF-H DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG65885|UniProtKB=T1FYE1 T1FYE1 20213839 PTHR15967:SF0 E2F-ASSOCIATED PHOSPHOPROTEIN E2F-ASSOCIATED PHOSPHOPROTEIN membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG183211|UniProtKB=T1FJB4 T1FJB4 20208913 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179416|UniProtKB=T1FEN9 T1FEN9 20207288 PTHR21231:SF7 XPA-BINDING PROTEIN 1-RELATED GPN-LOOP GTPASE 3 hydrolase activity#GO:0016787;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 small GTPase#PC00208;G-protein#PC00020;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG159187|UniProtKB=T1ENQ2 T1ENQ2 20198202 PTHR10920:SF13 RIBOSOMAL RNA METHYLTRANSFERASE PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3 catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;methyltransferase activity#GO:0008168;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;RNA methyltransferase activity#GO:0008173 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;methylation#GO:0032259;macromolecule methylation#GO:0043414;nitrogen compound metabolic process#GO:0006807;RNA methylation#GO:0001510;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG177703|UniProtKB=T1FC39 T1FC39 20206388 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG156872|UniProtKB=T1EM23 T1EM23 20197623 PTHR13449:SF2 INTEGRAL MEMBRANE PROTEIN GPR177 PROTEIN WNTLESS HOMOLOG protein binding#GO:0005515;Wnt-protein binding#GO:0017147;binding#GO:0005488 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;protein secretion#GO:0009306;cell communication#GO:0007154;cell-cell signaling by wnt#GO:0198738;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;regulation of biological process#GO:0050789;establishment of protein localization to extracellular region#GO:0035592;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;secretion#GO:0046903;protein transport#GO:0015031;biological regulation#GO:0065007;signal release#GO:0023061;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;protein localization to extracellular region#GO:0071692;cell-cell signaling#GO:0007267;signaling#GO:0023052;export from cell#GO:0140352;secretion by cell#GO:0032940 membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG172534|UniProtKB=T1F5H2 T1F5H2 20204071 PTHR23322:SF93 FAS-ASSOCIATED PROTEIN UBX DOMAIN-CONTAINING PROTEIN 8 protein binding#GO:0005515;ubiquitin-like protein binding#GO:0032182;binding#GO:0005488;ubiquitin binding#GO:0043130 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG180765|UniProtKB=T1FG90 T1FG90 20207839 PTHR12219:SF8 NADH-UBIQUINONE OXIDOREDUCTASE NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG80453|UniProtKB=T1G409 T1G409 20215807 PTHR47977:SF64 RAS-RELATED PROTEIN RAB RAS-RELATED PROTEIN RAB-30 GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;transport#GO:0006810 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG181698|UniProtKB=T1FH87 T1FH87 20208186 PTHR14596:SF72 ZINC FINGER PROTEIN ZINC FINGER PROTEIN MSN2-RELATED cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to nutrient levels#GO:0031667;response to extracellular stimulus#GO:0009991;response to stress#GO:0006950;response to starvation#GO:0042594 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG191501|UniProtKB=T1FT17 T1FT17 20211964 PTHR19423:SF1 SH3 DOMAIN-BINDING PROTEIN 5 SH3 DOMAIN-BINDING PROTEIN 5 enzyme inhibitor activity#GO:0004857;protein kinase regulator activity#GO:0019887;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase inhibitor activity#GO:0004860 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG83714|UniProtKB=T1G595 T1G595 20216242 PTHR24031:SF89 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX31-RELATED cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;ribosome biogenesis#GO:0042254;cellular process#GO:0009987;ribonucleoprotein complex biogenesis#GO:0022613 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG163642|UniProtKB=T1EUA9 T1EUA9 20200159 PTHR19282:SF534 TETRASPANIN TETRASPANIN FAMILY-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG169350|UniProtKB=T1F1T6 T1F1T6 20202786 PTHR45715:SF6 ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED V-TYPE PROTON ATPASE SUBUNIT E inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;proton transmembrane transporter activity#GO:0015078;active monoatomic ion transmembrane transporter activity#GO:0022853;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;inorganic cation transmembrane transporter activity#GO:0022890 HELRO|EnsemblGenome=HelroG143239|UniProtKB=T1EJ95 T1EJ95 20196645 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN SI:DKEY-17M8.2 HELRO|EnsemblGenome=HelroG77434|UniProtKB=T1G2X6 T1G2X6 20215424 PTHR11920:SF501 GUANYLYL CYCLASE GUANYLATE CYCLASE 32E adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG185219|UniProtKB=T1FMI7 T1FMI7 20210036 PTHR23050:SF518 CALCIUM BINDING PROTEIN AT16150P-RELATED cation binding#GO:0043169;small molecule binding#GO:0036094;molecular function regulator activity#GO:0098772;binding#GO:0005488;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;enzyme regulator activity#GO:0030234 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061 B cell activation#P00010>Calmodulin#P00375;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Calmodulin#P00755;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716;T cell activation#P00053>Calmodulin#P01305 HELRO|EnsemblGenome=HelroG183119|UniProtKB=T1FJ59 T1FJ59 20208858 PTHR14312:SF1 CREB/ATF BZIP TRANSCRIPTION FACTOR BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR A sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG184395|UniProtKB=T1FL43 T1FL43 20209542 PTHR46169:SF29 DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG181969|UniProtKB=T1FHJ5 T1FHJ5 20208294 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG168751|UniProtKB=T1F0X4 T1F0X4 20202474 PTHR10972:SF102 OXYSTEROL-BINDING PROTEIN-RELATED OXYSTEROL-BINDING PROTEIN binding#GO:0005488;organic cyclic compound binding#GO:0097159;steroid binding#GO:0005496;sterol transporter activity#GO:0015248;sterol binding#GO:0032934;lipid binding#GO:0008289;lipid transporter activity#GO:0005319;transporter activity#GO:0005215 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG74247|UniProtKB=T1G1N8 T1G1N8 20214986 PTHR11749:SF3 RIBULOSE-5-PHOSPHATE-3-EPIMERASE RIBULOSE-PHOSPHATE 3-EPIMERASE cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;metal ion binding#GO:0046872;racemase and epimerase activity, acting on carbohydrates and derivatives#GO:0016857;ion binding#GO:0043167;isomerase activity#GO:0016853 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;carbohydrate derivative metabolic process#GO:1901135;generation of precursor metabolites and energy#GO:0006091;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;pyridine nucleotide metabolic process#GO:0019362;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;glucose 6-phosphate metabolic process#GO:0051156;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;carbohydrate metabolic process#GO:0005975;NADP metabolic process#GO:0006739;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;nucleobase-containing small molecule metabolic process#GO:0055086;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 Ascorbate degradation#P02729>L-xylulose-5-phosphate-3-epimerase#P02852 HELRO|EnsemblGenome=HelroG189723|UniProtKB=T1FRA7 T1FRA7 20211354 PTHR45872:SF2 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;binding#GO:0005488;molecular function regulator activity#GO:0098772;protein binding#GO:0005515;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG176953|UniProtKB=T1FB24 T1FB24 20206023 PTHR14195:SF2 G PATCH DOMAIN CONTAINING PROTEIN 2 GH10944P membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG155469|UniProtKB=T1ELI4 T1ELI4 20197434 PTHR11850:SF266 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS HOMEOBOX PROTEIN HOMOTHORAX DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;animal organ development#GO:0048513;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of cell population proliferation#GO:0008284;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;system development#GO:0048731;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;anatomical structure morphogenesis#GO:0009653;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;visual system development#GO:0150063;sensory system development#GO:0048880;pattern specification process#GO:0007389;positive regulation of biological process#GO:0048518;regulation of cell population proliferation#GO:0042127;regulation of DNA-templated transcription#GO:0006355;multicellular organism development#GO:0007275;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;embryo development#GO:0009790;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;eye development#GO:0001654;biological regulation#GO:0065007;animal organ morphogenesis#GO:0009887;multicellular organismal process#GO:0032501;positive regulation of RNA metabolic process#GO:0051254;sensory organ development#GO:0007423;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG166662|UniProtKB=T1EYB9 T1EYB9 20201569 PTHR23019:SF0 NUCLEAR PORE MEMBRANE GLYCOPROTEIN GP210-RELATED NUCLEAR PORE MEMBRANE GLYCOPROTEIN 210 transporter#PC00227 HELRO|EnsemblGenome=HelroG80522|UniProtKB=T1G418 T1G418 20215816 PTHR16231:SF4 COMM DOMAIN-CONTAINING PROTEIN 4-8 FAMILY MEMBER COMM DOMAIN-CONTAINING PROTEIN 4 HELRO|EnsemblGenome=HelroG183629|UniProtKB=T1FJY7 T1FJY7 20209136 PTHR47293:SF15 JACALIN-RELATED LECTIN 3 JACALIN-RELATED LECTIN 19 HELRO|EnsemblGenome=HelroG160533|UniProtKB=T1EQD4 T1EQD4 20198784 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG179341|UniProtKB=T1FEK7 T1FEK7 20207256 PTHR13559:SF1 INTRACELLULAR TRAFFIC PROTEIN-RELATED PROTEIN FUZZY HOMOLOG organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;cellular component assembly#GO:0022607;non-motile cilium assembly#GO:1905515;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 HELRO|EnsemblGenome=HelroG159143|UniProtKB=T1ENN5 T1ENN5 20198185 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG167234|UniProtKB=T1EZ59 T1EZ59 20201859 PTHR12673:SF241 FACIOGENITAL DYSPLASIA PROTEIN DH DOMAIN-CONTAINING PROTEIN nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cell projection organization#GO:0030030;organelle organization#GO:0006996;filopodium assembly#GO:0046847;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG160343|UniProtKB=T1EQ43 T1EQ43 20198693 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164396|UniProtKB=T1EVD7 T1EVD7 20200537 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164021|UniProtKB=T1EUS3 T1EUS3 20200323 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG110926|UniProtKB=T1EF63 T1EF63 20195215 PTHR12315:SF0 BICOID-INTERACTING PROTEIN RELATED 7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME catalytic activity, acting on RNA#GO:0140098;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;transferase activity#GO:0016740;O-methyltransferase activity#GO:0008171;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640;methyltransferase activity#GO:0008168;snRNA binding#GO:0017069;transferase activity, transferring one-carbon groups#GO:0016741;RNA methyltransferase activity#GO:0008173 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;snRNA metabolic process#GO:0016073;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG113800|UniProtKB=T1EFW8 T1EFW8 20195470 PTHR11630:SF42 DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER DNA REPLICATION LICENSING FACTOR MCM5 ATP-dependent activity, acting on DNA#GO:0008094;nucleic acid binding#GO:0003676;3'-5' DNA helicase activity#GO:0043138;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;single-stranded DNA binding#GO:0003697;DNA binding#GO:0003677;catalytic activity, acting on a nucleic acid#GO:0140640;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097;single-stranded DNA helicase activity#GO:0017116 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;double-strand break repair via homologous recombination#GO:0000724;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;response to stress#GO:0006950;double-strand break repair via break-induced replication#GO:0000727;nitrogen compound metabolic process#GO:0006807;recombinational repair#GO:0000725;DNA-templated DNA replication#GO:0006261;DNA replication#GO:0006260;cellular response to stress#GO:0033554;DNA replication initiation#GO:0006270;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;metabolic process#GO:0008152 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;MCM complex#GO:0042555;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 Parkinson disease#P00049>Hsp70#P01208;Apoptosis signaling pathway#P00006>HSP70#P00321 HELRO|EnsemblGenome=HelroG168829|UniProtKB=T1F106 T1F106 20202506 PTHR11558:SF11 SPERMIDINE/SPERMINE SYNTHASE SPERMIDINE SYNTHASE transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG162910|UniProtKB=T1ETC3 T1ETC3 20199823 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG113689|UniProtKB=T1EFV0 T1EFV0 20195452 PTHR11587:SF2 ARGININOSUCCINATE SYNTHASE ARGININOSUCCINATE SYNTHASE ligase activity#GO:0016874;catalytic activity#GO:0003824 proteinogenic amino acid biosynthetic process#GO:0170038;biosynthetic process#GO:0009058;carboxylic acid biosynthetic process#GO:0046394;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;cellular modified amino acid metabolic process#GO:0006575;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;amide metabolic process#GO:0043603;L-amino acid metabolic process#GO:0170033;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;organic acid biosynthetic process#GO:0016053;proteinogenic amino acid metabolic process#GO:0170039;oxoacid metabolic process#GO:0043436;arginine metabolic process#GO:0006525;organonitrogen compound biosynthetic process#GO:1901566;cellular metabolic process#GO:0044237;organonitrogen compound metabolic process#GO:1901564;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;alpha-amino acid biosynthetic process#GO:1901607;L-amino acid biosynthetic process#GO:0170034;small molecule biosynthetic process#GO:0044283;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 Arginine biosynthesis#P02728>Argininosuccinate synthase#P02840 HELRO|EnsemblGenome=HelroG105874|UniProtKB=T1EDY1 T1EDY1 20194783 PTHR31488:SF1 DPY-19-LIKE 1, LIKE (H. SAPIENS) C-MANNOSYLTRANSFERASE DPY19L1 mannosyltransferase activity#GO:0000030;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein mannosylation#GO:0035268;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085;mannosylation#GO:0097502 envelope#GO:0031975;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;organelle membrane#GO:0031090;organelle inner membrane#GO:0019866;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;nuclear membrane#GO:0031965;endomembrane system#GO:0012505;nuclear inner membrane#GO:0005637;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG174283|UniProtKB=T1F7X7 T1F7X7 20204926 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG78909|UniProtKB=T1G3H2 T1G3H2 20215620 PTHR13072:SF0 DYNACTIN 6 DYNACTIN SUBUNIT 6 protein-containing complex binding#GO:0044877;binding#GO:0005488;dynein complex binding#GO:0070840 cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;mitotic spindle organization#GO:0007052;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;cell cycle#GO:0007049;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;spindle organization#GO:0007051;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;microtubule cytoskeleton#GO:0015630;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG159338|UniProtKB=T1ENW8 T1ENW8 20198268 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185942|UniProtKB=T1FNG8 T1FNG8 20210365 PTHR24073:SF212 DRAB5-RELATED FI01544P GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 localization#GO:0051179;organic substance transport#GO:0071702;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;protein transport#GO:0015031;nitrogen compound transport#GO:0071705;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG99567|UniProtKB=T1G9T7 T1G9T7 20217833 PTHR12320:SF1 PROTEIN PHOSPHATASE 2C PROTEIN PHOSPHATASE PTC7 HOMOLOG hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;dephosphorylation#GO:0016311;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG63211|UniProtKB=T1FXC4 T1FXC4 20213472 PTHR13326:SF31 TRNA PSEUDOURIDINE SYNTHASE D PSEUDOURIDYLATE SYNTHASE 7 HOMOLOG isomerase activity#GO:0016853;intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;pseudouridine synthesis#GO:0001522;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG177689|UniProtKB=T1FC31 T1FC31 20206380 PTHR14596:SF72 ZINC FINGER PROTEIN ZINC FINGER PROTEIN MSN2-RELATED cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to nutrient levels#GO:0031667;response to extracellular stimulus#GO:0009991;response to stress#GO:0006950;response to starvation#GO:0042594 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185543|UniProtKB=T1FMY6 T1FMY6 20210185 PTHR23139:SF9 RNA-BINDING PROTEIN SPLICING FACTOR U2AF 65 KDA SUBUNIT nucleic acid binding#GO:0003676;single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723;pre-mRNA binding#GO:0036002;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375;spliceosomal complex assembly#GO:0000245 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;U2-type spliceosomal complex#GO:0005684;nuclear speck#GO:0016607;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear body#GO:0016604;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;U2-type prespliceosome#GO:0071004;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG191755|UniProtKB=T1FT99 T1FT99 20212046 PTHR45803:SF5 SOX100B SOX100B sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG168229|UniProtKB=T1F0C2 T1F0C2 20202272 PTHR23382:SF3 MALATE DEHYDROGENASE MALATE DEHYDROGENASE, CYTOPLASMIC oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 cellular aromatic compound metabolic process#GO:0006725;dicarboxylic acid metabolic process#GO:0043648;pyridine nucleotide metabolic process#GO:0019362;nucleobase-containing compound metabolic process#GO:0006139;energy derivation by oxidation of organic compounds#GO:0015980;phosphorus metabolic process#GO:0006793;tricarboxylic acid cycle#GO:0006099;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;oxoacid metabolic process#GO:0043436;generation of precursor metabolites and energy#GO:0006091;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;nicotinamide nucleotide metabolic process#GO:0046496;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;carboxylic acid metabolic process#GO:0019752;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 dehydrogenase#PC00092;oxidoreductase#PC00176 TCA cycle#P00051>Malate Dehydrogenase#P01270 HELRO|EnsemblGenome=HelroG108214|UniProtKB=T1EEH0 T1EEH0 20194972 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG190886|UniProtKB=T1FSE1 T1FSE1 20211738 PTHR45617:SF172 LEUCINE RICH REPEAT FAMILY PROTEIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN 15-LIKE scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194408|UniProtKB=T1FW09 T1FW09 20213005 PTHR10824:SF4 ACYL-COENZYME A THIOESTERASE-RELATED ACYL-COENZYME A THIOESTERASE 1-LIKE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;fatty acyl-CoA hydrolase activity#GO:0047617;catalytic activity#GO:0003824;thiolester hydrolase activity#GO:0016790 cellular aromatic compound metabolic process#GO:0006725;lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;sulfur compound metabolic process#GO:0006790;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;amide metabolic process#GO:0043603;purine nucleotide metabolic process#GO:0006163;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;oxoacid metabolic process#GO:0043436;heterocycle metabolic process#GO:0046483;acyl-CoA metabolic process#GO:0006637;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;ribonucleotide metabolic process#GO:0009259;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;purine ribonucleotide metabolic process#GO:0009150;fatty acid metabolic process#GO:0006631;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;cellular lipid metabolic process#GO:0044255;carboxylic acid metabolic process#GO:0019752;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 esterase#PC00097 HELRO|EnsemblGenome=HelroG77660|UniProtKB=T1G317 T1G317 20215465 PTHR14237:SF80 MOLYBDOPTERIN COFACTOR SULFURASE MOSC MOLYBDENUM COFACTOR SULFURASE HELRO|EnsemblGenome=HelroG169536|UniProtKB=T1F221 T1F221 20202871 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161481|UniProtKB=T1ERI9 T1ERI9 20199189 PTHR10454:SF210 CASPASE CASPASE-2 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG162160|UniProtKB=T1ESA6 T1ESA6 20199456 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185290|UniProtKB=T1FMM1 T1FMM1 20210070 PTHR11573:SF6 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;oxidoreductase activity#GO:0016491;ATP binding#GO:0005524 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;carbohydrate derivative biosynthetic process#GO:1901137;organic cyclic compound metabolic process#GO:1901360;nucleobase-containing compound biosynthetic process#GO:0034654;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;nucleobase-containing small molecule metabolic process#GO:0055086 cytoplasm#GO:0005737;oxidoreductase complex#GO:1990204;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 reductase#PC00198;oxidoreductase#PC00176 De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>CDP Reductase#P02915;De novo purine biosynthesis#P02738>ADP reductase#P02902;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>UDP reductase#P02921;De novo purine biosynthesis#P02738>GDP reductase#P02909 HELRO|EnsemblGenome=HelroG172950|UniProtKB=T1F668 T1F668 20204317 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG92244|UniProtKB=T1G8D4 T1G8D4 20217331 PTHR11711:SF451 ADP RIBOSYLATION FACTOR-RELATED SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT BETA carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 G-protein#PC00020 HELRO|EnsemblGenome=HelroG193290|UniProtKB=T1FUU3 T1FUU3 20212589 PTHR11051:SF8 GLYCOSYL HYDROLASE-RELATED PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 carbohydrate metabolic process#GO:0005975;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238;metabolic process#GO:0008152 glycosidase#PC00110;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG74899|UniProtKB=T1G1X5 T1G1X5 20215073 PTHR10317:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;translational initiation#GO:0006413;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;eukaryotic translation initiation factor 3 complex#GO:0005852;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG165501|UniProtKB=T1EWX3 T1EWX3 20201073 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG186041|UniProtKB=T1FNL0 T1FNL0 20210407 PTHR11702:SF43 DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED GTP-BINDING PROTEIN 10 GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG163087|UniProtKB=T1ETN0 T1ETN0 20199930 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG168960|UniProtKB=T1F172 T1F172 20202572 PTHR18867:SF12 RAD50 DNA REPAIR PROTEIN RAD50 sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;single-stranded telomeric DNA binding#GO:0043047;single-stranded DNA binding#GO:0003697;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;telomeric DNA binding#GO:0042162;double-stranded DNA binding#GO:0003690 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;telomere maintenance via telomere lengthening#GO:0010833;double-strand break repair#GO:0006302;telomere organization#GO:0032200;cell cycle process#GO:0022402;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;telomere maintenance#GO:0000723;DNA geometric change#GO:0032392;DNA damage response#GO:0006974;chromosome organization involved in meiotic cell cycle#GO:0070192;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;meiotic cell cycle process#GO:1903046;cellular nitrogen compound biosynthetic process#GO:0044271;DNA duplex unwinding#GO:0032508;mitotic recombination#GO:0006312;reproductive process#GO:0022414;telomere maintenance via telomerase#GO:0007004;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;meiotic cell cycle#GO:0051321;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;cellular component organization or biogenesis#GO:0071840;DNA conformation change#GO:0071103;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;response to stress#GO:0006950;reproduction#GO:0000003;organelle organization#GO:0006996;chromosome organization#GO:0051276;DNA biosynthetic process#GO:0071897;sexual reproduction#GO:0019953;cell cycle#GO:0007049;aromatic compound biosynthetic process#GO:0019438;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;condensed chromosome#GO:0000793;intracellular organelle lumen#GO:0070013;condensed nuclear chromosome#GO:0000794;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG97866|UniProtKB=T1G9J4 T1G9J4 20217740 PTHR12274:SF3 GRANULIN PROGRANULIN cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 HELRO|EnsemblGenome=HelroG92006|UniProtKB=T1G8B3 T1G8B3 20217310 PTHR24115:SF191 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF9 pyrophosphatase activity#GO:0016462;cytoskeletal protein binding#GO:0008092;microtubule motor activity#GO:0003777;tubulin binding#GO:0015631;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;cytoskeletal motor activity#GO:0003774;microtubule binding#GO:0008017;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;microtubule associated complex#GO:0005875;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG194632|UniProtKB=T1FW90 T1FW90 20213086 PTHR14453:SF67 PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN POLY [ADP-RIBOSE] POLYMERASE molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;protein-macromolecule adaptor activity#GO:0030674 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG105627|UniProtKB=T1EDW8 T1EDW8 20194770 PTHR21355:SF0 G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2 G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG106099|UniProtKB=T1EE01 T1EE01 20194803 PTHR13353:SF5 TRANSMEMBRANE PROTEIN 19 TRANSMEMBRANE PROTEIN 19 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG165973|UniProtKB=T1EXI8 T1EXI8 20201288 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163862|UniProtKB=T1EUJ8 T1EUJ8 20200248 PTHR23003:SF3 RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN FI21236P1-RELATED nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG108539|UniProtKB=T1EEK1 T1EEK1 20195003 PTHR22594:SF16 ASPARTYL/LYSYL-TRNA SYNTHETASE ASPARAGINE--TRNA LIGASE, CYTOPLASMIC catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG157169|UniProtKB=T1EM75 T1EM75 20197675 PTHR11528:SF97 HEAT SHOCK PROTEIN 90 FAMILY MEMBER ENDOPLASMIN protein binding#GO:0005515;unfolded protein binding#GO:0051082;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 Hsp90 family chaperone#PC00028 HELRO|EnsemblGenome=HelroG71763|UniProtKB=T1G0R2 T1G0R2 20214660 PTHR18952:SF265 CARBONIC ANHYDRASE CARBONIC ANHYDRASE dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG190144|UniProtKB=T1FRQ5 T1FRQ5 20211502 PTHR17598:SF13 DNA POLYMERASE DELTA SUBUNIT 3 DNA POLYMERASE DELTA SUBUNIT 3 DNA-directed DNA polymerase activity#GO:0003887;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on DNA#GO:0140097;DNA polymerase activity#GO:0034061 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;response to radiation#GO:0009314;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated DNA replication#GO:0006261;response to abiotic stimulus#GO:0009628;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular response to light stimulus#GO:0071482;nucleotide-excision repair#GO:0006289;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;response to light stimulus#GO:0009416;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;nucleobase-containing compound biosynthetic process#GO:0034654;response to UV#GO:0009411;DNA biosynthetic process#GO:0071897;DNA synthesis involved in DNA repair#GO:0000731;aromatic compound biosynthetic process#GO:0019438;DNA replication#GO:0006260;cellular response to stress#GO:0033554;DNA strand elongation involved in DNA replication#GO:0006271;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;transferase complex#GO:1990234;replisome#GO:0030894;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;DNA polymerase complex#GO:0042575;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nuclear replication fork#GO:0043596;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513;replication fork#GO:0005657 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG190078|UniProtKB=T1FRN8 T1FRN8 20211485 PTHR24093:SF369 CATION TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE calcium ion transmembrane transporter activity#GO:0015085;inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;P-type ion transporter activity#GO:0015662;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075 intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG184100|UniProtKB=T1FKK7 T1FKK7 20209356 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG68492|UniProtKB=T1FZF6 T1FZF6 20214204 PTHR10701:SF5 SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG185395|UniProtKB=T1FMR5 T1FMR5 20210114 PTHR45709:SF3 LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 1 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG74014|UniProtKB=T1G1L1 T1G1L1 20214959 PTHR10682:SF10 POLY A POLYMERASE POLYNUCLEOTIDE ADENYLYLTRANSFERASE adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;mRNA polyadenylation#GO:0006378;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;mRNA 3'-end processing#GO:0031124;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mRNA processing#GO:0006397;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG64321|UniProtKB=T1FXS8 T1FXS8 20213626 PTHR10658:SF11 PHOSPHATIDYLINOSITOL TRANSFER PROTEIN VIBRATOR, ISOFORM B transporter#PC00227 HELRO|EnsemblGenome=HelroG182927|UniProtKB=T1FIX7 T1FIX7 20208776 PTHR10334:SF498 CYSTEINE-RICH SECRETORY PROTEIN-RELATED MIP16674P defense/immunity protein#PC00090 PI3 kinase pathway#P00048>scl-1#G01545 HELRO|EnsemblGenome=HelroG100226|UniProtKB=T1ECZ0 T1ECZ0 20194442 PTHR12841:SF6 PROTEIN UNC-50 HOMOLOG PROTEIN UNC-50 HOMOLOG cytoplasm#GO:0005737;bounding membrane of organelle#GO:0098588;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG179049|UniProtKB=T1FE37 T1FE37 20207086 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG78435|UniProtKB=T1G3B7 T1G3B7 20215565 PTHR19957:SF424 SYNTAXIN SYNTAXIN-1A molecular adaptor activity#GO:0060090;protein binding#GO:0005515;SNAP receptor activity#GO:0005484;binding#GO:0005488;SNARE binding#GO:0000149;protein-macromolecule adaptor activity#GO:0030674 vesicle fusion#GO:0006906;cellular localization#GO:0051641;organelle localization#GO:0051640;macromolecule localization#GO:0033036;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;membrane fusion#GO:0061025;exocytosis#GO:0006887;establishment of localization#GO:0051234;organelle organization#GO:0006996;secretion#GO:0046903;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;vesicle organization#GO:0016050;intracellular transport#GO:0046907;export from cell#GO:0140352;secretion by cell#GO:0032940;organelle fusion#GO:0048284 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;SNARE complex#GO:0031201;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034;membrane traffic protein#PC00150 Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079 HELRO|EnsemblGenome=HelroG169322|UniProtKB=T1F1S0 T1F1S0 20202770 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG113133|UniProtKB=T1EFQ5 T1EFQ5 20195407 PTHR45887:SF1 TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON nucleoside-triphosphatase regulator activity#GO:0060589;nucleic acid binding#GO:0003676;translation initiation factor binding#GO:0031369;translation regulator activity#GO:0045182;GTPase regulator activity#GO:0030695;binding#GO:0005488;organic cyclic compound binding#GO:0097159;molecular function regulator activity#GO:0098772;translation initiation factor activity#GO:0003743;protein binding#GO:0005515;translation regulator activity, nucleic acid binding#GO:0090079;enzyme regulator activity#GO:0030234;translation factor activity, RNA binding#GO:0008135;guanyl-nucleotide exchange factor activity#GO:0005085 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG69129|UniProtKB=T1FZQ0 T1FZQ0 20214298 PTHR13069:SF21 ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8 ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8 HELRO|EnsemblGenome=HelroG163782|UniProtKB=T1EUG9 T1EUG9 20200219 PTHR10677:SF3 UBIQUILIN FI07626P-RELATED protein binding#GO:0005515;binding#GO:0005488;polyubiquitin modification-dependent protein binding#GO:0031593;modification-dependent protein binding#GO:0140030 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG102128|UniProtKB=T1ED82 T1ED82 20194534 PTHR15588:SF8 LSM1 U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 negative regulation of gene expression#GO:0010629;regulation of catabolic process#GO:0009894;heterocycle catabolic process#GO:0046700;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;nucleobase-containing compound metabolic process#GO:0006139;RNA destabilization#GO:0050779;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;regulation of biological quality#GO:0065008;nitrogen compound metabolic process#GO:0006807;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;positive regulation of mRNA catabolic process#GO:0061014;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of catabolic process#GO:0009896;mRNA destabilization#GO:0061157;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323;positive regulation of nitrogen compound metabolic process#GO:0051173;cellular aromatic compound metabolic process#GO:0006725;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;RNA metabolic process#GO:0016070;positive regulation of cellular catabolic process#GO:0031331;cellular nitrogen compound catabolic process#GO:0044270;RNA decapping#GO:0110154;organic cyclic compound metabolic process#GO:1901360;positive regulation of metabolic process#GO:0009893;mRNA catabolic process#GO:0006402;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;positive regulation of mRNA metabolic process#GO:1903313;heterocycle metabolic process#GO:0046483;negative regulation of biosynthetic process#GO:0009890;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of cellular catabolic process#GO:0031329;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;positive regulation of RNA metabolic process#GO:0051254 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;protein-containing complex#GO:0032991;P-body#GO:0000932;cellular anatomical entity#GO:0110165;organelle#GO:0043226;Sm-like protein family complex#GO:0120114;intracellular organelle#GO:0043229;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG184934|UniProtKB=T1FM66 T1FM66 20209915 PTHR24073:SF185 DRAB5-RELATED RAS-RELATED PROTEIN RAB-14 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 localization#GO:0051179;organic substance transport#GO:0071702;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;protein transport#GO:0015031;nitrogen compound transport#GO:0071705;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG171298|UniProtKB=T1F419 T1F419 20203568 PTHR15698:SF10 PROTEIN CBG15099 PHYTANOYL-COA HYDROXYLASE-INTERACTING PROTEIN-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG155739|UniProtKB=T1ELL7 T1ELL7 20197467 PTHR45857:SF4 FORMIN-LIKE PROTEIN FORMIN-LIKE PROTEIN HELRO|EnsemblGenome=HelroG167073|UniProtKB=T1EYZ2 T1EYZ2 20201792 PTHR14611:SF2 TECTONIC FAMILY MEMBER TECTONIC HELRO|EnsemblGenome=HelroG188733|UniProtKB=T1FQB2 T1FQB2 20211009 PTHR14084:SF0 KYNURENINASE KYNURENINASE hydrolase activity#GO:0016787;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;heterocycle catabolic process#GO:0046700;biogenic amine metabolic process#GO:0006576;organonitrogen compound catabolic process#GO:1901565;cellular nitrogen compound catabolic process#GO:0044270;amino acid catabolic process#GO:0009063;organic cyclic compound metabolic process#GO:1901360;aromatic amino acid metabolic process#GO:0009072;nitrogen compound metabolic process#GO:0006807;alpha-amino acid metabolic process#GO:1901605;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248;heterocycle metabolic process#GO:0046483;amine metabolic process#GO:0009308;oxoacid metabolic process#GO:0043436;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;aromatic compound catabolic process#GO:0019439;organic cyclic compound catabolic process#GO:1901361;aromatic amino acid family catabolic process#GO:0009074;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG189998|UniProtKB=T1FRK7 T1FRK7 20211454 PTHR13600:SF33 LEUCINE CARBOXYL METHYLTRANSFERASE LEUCINE CARBOXYL METHYLTRANSFERASE 1 transferase activity#GO:0016740;O-methyltransferase activity#GO:0008171;catalytic activity#GO:0003824;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a protein#GO:0140096;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein methyltransferase activity#GO:0008276 macromolecule methylation#GO:0043414;methylation#GO:0032259;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG157419|UniProtKB=T1EMB3 T1EMB3 20197713 PTHR13768:SF8 SOLUBLE NSF ATTACHMENT PROTEIN SNAP ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN syntaxin binding#GO:0019905;molecular adaptor activity#GO:0060090;protein binding#GO:0005515;binding#GO:0005488;SNARE binding#GO:0000149;protein-macromolecule adaptor activity#GO:0030674 cellular localization#GO:0051641;protein-containing complex disassembly#GO:0032984;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;cellular component disassembly#GO:0022411;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein-containing complex organization#GO:0043933;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;vacuolar membrane#GO:0005774;SNARE complex#GO:0031201;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG183983|UniProtKB=T1FKE1 T1FKE1 20209290 PTHR45817:SF4 LYSYL OXIDASE-LIKE-RELATED LYSYL OXIDASE-LIKE-RELATED catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 oxidase#PC00175;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG88618|UniProtKB=T1G744 T1G744 20216891 PTHR11849:SF190 ETS ETS-DOMAIN PROTEIN transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG161390|UniProtKB=T1ERF3 T1ERF3 20199153 PTHR31809:SF0 BUD13 HOMOLOG BUD13 HOMOLOG nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;U2-type spliceosomal complex#GO:0005684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG180301|UniProtKB=T1FFQ0 T1FFQ0 20207649 PTHR11088:SF89 TRNA DIMETHYLALLYLTRANSFERASE TRNA DIMETHYLALLYLTRANSFERASE catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG72007|UniProtKB=T1G0U0 T1G0U0 20214688 PTHR10769:SF3 40S RIBOSOMAL PROTEIN S28 SMALL RIBOSOMAL SUBUNIT PROTEIN ES28 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;ribosome biogenesis#GO:0042254;non-membrane-bounded organelle assembly#GO:0140694;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;organelle organization#GO:0006996;rRNA metabolic process#GO:0016072;protein-containing complex organization#GO:0043933;ribonucleoprotein complex biogenesis#GO:0022613;protein-RNA complex organization#GO:0071826;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;cytosol#GO:0005829;small ribosomal subunit#GO:0015935;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG176020|UniProtKB=T1FA11 T1FA11 20205660 PTHR24381:SF450 ZINC FINGER PROTEIN GASTRULA ZINC FINGER PROTEIN XLCGF26.1-LIKE-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG191233|UniProtKB=T1FSR7 T1FSR7 20211864 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG173478|UniProtKB=T1F6V3 T1F6V3 20204552 PTHR10891:SF918 EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN CALCIUM-BINDING PROTEIN 2 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG181565|UniProtKB=T1FH42 T1FH42 20208141 PTHR13135:SF0 CYTOSOLIC RESINIFERATOXIN BINDING PROTEIN RBP-26 PHOSPHORYLATED ADAPTER RNA EXPORT PROTEIN RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG84633|UniProtKB=T1G5L3 T1G5L3 20216360 PTHR10283:SF136 SOLUTE CARRIER FAMILY 13 MEMBER CITRATE TRANSPORTER-LIKE DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG79669|UniProtKB=T1G3S0 T1G3S0 20215718 PTHR24416:SF550 TYROSINE-PROTEIN KINASE RECEPTOR FIBROBLAST GROWTH FACTOR RECEPTOR HOMOLOG 1-RELATED signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG169937|UniProtKB=T1F2G4 T1F2G4 20203014 PTHR23167:SF88 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG186784|UniProtKB=T1FP35 T1FP35 20210582 PTHR13317:SF4 TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG180956|UniProtKB=T1FGG6 T1FGG6 20207915 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185536|UniProtKB=T1FMY0 T1FMY0 20210179 PTHR13315:SF4 METALLO PHOSPHOESTERASE RELATED METALLOPHOSPHOESTERASE, ISOFORM E lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;phospholipid biosynthetic process#GO:0008654;macromolecule modification#GO:0043412;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycolipid metabolic process#GO:0006664;protein modification process#GO:0036211;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;glycerolipid biosynthetic process#GO:0045017;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;organic substance biosynthetic process#GO:1901576;liposaccharide metabolic process#GO:1903509;cellular process#GO:0009987;GPI anchor metabolic process#GO:0006505;membrane lipid biosynthetic process#GO:0046467;lipoprotein biosynthetic process#GO:0042158;primary metabolic process#GO:0044238;GPI anchor biosynthetic process#GO:0006506;carbohydrate derivative biosynthetic process#GO:1901137;membrane lipid metabolic process#GO:0006643;glycerophospholipid biosynthetic process#GO:0046474;glycolipid biosynthetic process#GO:0009247;organophosphate metabolic process#GO:0019637;lipoprotein metabolic process#GO:0042157;cellular lipid metabolic process#GO:0044255 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 esterase#PC00097 HELRO|EnsemblGenome=HelroG79367|UniProtKB=T1G3N3 T1G3N3 20215681 PTHR45810:SF1 HISTONE H3.2 HISTONE H3-LIKE CENTROMERIC PROTEIN A chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG169378|UniProtKB=T1F1V5 T1F1V5 20202805 PTHR13593:SF113 FAMILY NOT NAMED SI:DKEY-266F7.9 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric diester hydrolase activity#GO:0008081;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 HELRO|EnsemblGenome=HelroG177956|UniProtKB=T1FCI5 T1FCI5 20206534 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163239|UniProtKB=T1ETT8 T1ETT8 20199988 PTHR13866:SF14 SPARC OSTEONECTIN BM-40 cation binding#GO:0043169;extracellular matrix binding#GO:0050840;small molecule binding#GO:0036094;binding#GO:0005488;collagen binding#GO:0005518;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;protein-containing complex binding#GO:0044877;ion binding#GO:0043167 anatomical structure development#GO:0048856;developmental process#GO:0032502 extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 extracellular matrix glycoprotein#PC00100 HELRO|EnsemblGenome=HelroG185239|UniProtKB=T1FMJ7 T1FMJ7 20210046 PTHR18860:SF159 14-3-3 PROTEIN 14-3-3 PROTEIN ZETA localization#GO:0051179;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular localization#GO:0051641;cellular response to stimulus#GO:0051716;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052;protein localization#GO:0008104 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 Parkinson disease#P00049>14-3-3#P01238;FGF signaling pathway#P00021>14-3-3#P00624;EGF receptor signaling pathway#P00018>14-3-3#P00539;PI3 kinase pathway#P00048>14-3-3#P01206 HELRO|EnsemblGenome=HelroG162155|UniProtKB=T1ESA4 T1ESA4 20199454 PTHR11009:SF32 DER1-LIKE PROTEIN, DERLIN DERLIN ribonucleoprotein complex binding#GO:0043021;protein-containing complex binding#GO:0044877;binding#GO:0005488 signal transduction#GO:0007165;endoplasmic reticulum unfolded protein response#GO:0030968;protein catabolic process#GO:0030163;organonitrogen compound catabolic process#GO:1901565;regulation of biological process#GO:0050789;nitrogen compound metabolic process#GO:0006807;response to unfolded protein#GO:0006986;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;signaling#GO:0023052;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;response to organic substance#GO:0010033;macromolecule catabolic process#GO:0009057;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;cellular response to chemical stimulus#GO:0070887;cellular response to organic substance#GO:0071310;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;ERAD pathway#GO:0036503;cell communication#GO:0007154;response to organonitrogen compound#GO:0010243;cellular process#GO:0009987;cellular response to topologically incorrect protein#GO:0035967;primary metabolic process#GO:0044238;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;response to topologically incorrect protein#GO:0035966;cellular response to unfolded protein#GO:0034620;biological regulation#GO:0065007;cellular response to stress#GO:0033554 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG112230|UniProtKB=T1EFI0 T1EFI0 20195332 PTHR12789:SF0 DENSITY-REGULATED PROTEIN HOMOLOG DENSITY-REGULATED PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular component biogenesis#GO:0044085;peptide metabolic process#GO:0006518;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;translation#GO:0006412;protein-RNA complex assembly#GO:0022618;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cytoplasmic translation#GO:0002181;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;cytoplasmic translational initiation#GO:0002183;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;cellular component organization or biogenesis#GO:0071840;peptide biosynthetic process#GO:0043043;protein-containing complex organization#GO:0043933;ribonucleoprotein complex biogenesis#GO:0022613;translational initiation#GO:0006413;protein-RNA complex organization#GO:0071826 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG188693|UniProtKB=T1FQ96 T1FQ96 20210993 PTHR10126:SF69 TATA-BOX BINDING PROTEIN TATA BOX-BINDING PROTEIN-LIKE 1 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;gene expression#GO:0010467;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;aromatic compound biosynthetic process#GO:0019438;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 RNA metabolism protein#PC00031;general transcription factor#PC00259 General transcription by RNA polymerase I#P00022>SL1 complex#P00653;General transcription by RNA polymerase I#P00022>TBP#P00657;General transcription regulation#P00023>TBP#P00670;Transcription regulation by bZIP transcription factor#P00055>TBP#P01399 HELRO|EnsemblGenome=HelroG173412|UniProtKB=T1F6S6 T1F6S6 20204525 PTHR23353:SF36 RAB-GAP/TBC-RELATED LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG83020|UniProtKB=T1G4Z2 T1G4Z2 20216140 PTHR10780:SF18 MITOCHONDRIAL CARRIER HOMOLOG LD43650P mitochondrial carrier protein#PC00158;secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG185494|UniProtKB=T1FMW1 T1FMW1 20210160 PTHR11921:SF29 SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL cellular respiration#GO:0045333;aerobic respiration#GO:0009060;respiratory electron transport chain#GO:0022904;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;electron transport chain#GO:0022900;cellular process#GO:0009987;energy derivation by oxidation of organic compounds#GO:0015980;metabolic process#GO:0008152 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG187088|UniProtKB=T1FP68 T1FP68 20210615 PTHR24093:SF369 CATION TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE calcium ion transmembrane transporter activity#GO:0015085;inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;P-type ion transporter activity#GO:0015662;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075 intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG157952|UniProtKB=T1EMI0 T1EMI0 20197780 PTHR10894:SF0 NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58 NUCLEOLAR PROTEIN 56 snoRNA binding#GO:0030515;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG119254|UniProtKB=T1EGM8 T1EGM8 20195728 PTHR10153:SF44 SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;binding#GO:0005488;calmodulin binding#GO:0005516;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic ion-gated channel activity#GO:0022839;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium-activated cation channel activity#GO:0005227;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;protein binding#GO:0005515;monoatomic ion channel activity#GO:0005216;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 somatodendritic compartment#GO:0036477;cell body#GO:0044297;neuron projection#GO:0043005;neuronal cell body#GO:0043025;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG88197|UniProtKB=T1G6Z8 T1G6Z8 20216845 PTHR13703:SF45 SMAD MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG cis-regulatory region sequence-specific DNA binding#GO:0000987;SMAD binding#GO:0046332;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;protein binding#GO:0005515;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 signal transduction#GO:0007165;regulation of nitrogen compound metabolic process#GO:0051171;response to growth factor#GO:0070848;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;cellular response to BMP stimulus#GO:0071773;cell differentiation#GO:0030154;response to endogenous stimulus#GO:0009719;anatomical structure morphogenesis#GO:0009653;regulation of biosynthetic process#GO:0009889;response to BMP#GO:0071772;regulation of macromolecule biosynthetic process#GO:0010556;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;regulation of gene expression#GO:0010468;signaling#GO:0023052;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;cellular response to endogenous stimulus#GO:0071495;regulation of DNA-templated transcription#GO:0006355;BMP signaling pathway#GO:0030509;cell communication#GO:0007154;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;cellular response to growth factor stimulus#GO:0071363;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;cell surface receptor signaling pathway#GO:0007166;anatomical structure development#GO:0048856;transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0007178;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 MYO signaling pathway#P06215>MED#P06311;DPP signaling pathway#P06213>MED#P06279;DPP-SCW signaling pathway#P06212>MED#P06265;SCW signaling pathway#P06216>MED#P06323;Activin beta signaling pathway#P06210>MED#P06233;BMP/activin signaling pathway-drosophila#P06211>Co-Smad#P06254;TGF-beta signaling pathway#P00052>Co-Smads#P01276;TGF-beta signaling pathway#P00052>RSmads#P01292;ALP23B signaling pathway#P06209>MED#P06221;GBB signaling pathway#P06214>MED#P06299 HELRO|EnsemblGenome=HelroG187510|UniProtKB=T1FPA3 T1FPA3 20210650 PTHR12174:SF23 SIGNAL PEPTIDE PEPTIDASE MINOR HISTOCOMPATIBILITY ANTIGEN H13 hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;aspartic-type endopeptidase activity#GO:0004190;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;membrane protein proteolysis#GO:0033619;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;signal peptide processing#GO:0006465;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;side of membrane#GO:0098552;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 aspartic protease#PC00053;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG168602|UniProtKB=T1F0S4 T1F0S4 20202424 PTHR23121:SF9 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 transmembrane transporter activity#GO:0022857;sugar transmembrane transporter activity#GO:0051119;transporter activity#GO:0005215;carbohydrate transmembrane transporter activity#GO:0015144 transporter#PC00227 HELRO|EnsemblGenome=HelroG83856|UniProtKB=T1G5B1 T1G5B1 20216258 PTHR31859:SF9 TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER TETRATRICOPEPTIDE REPEAT PROTEIN 39B HELRO|EnsemblGenome=HelroG73751|UniProtKB=T1G1I0 T1G1I0 20214928 PTHR13085:SF0 MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT SIGNAL PEPTIDASE COMPLEX SUBUNIT 2 cellular localization#GO:0051641;macromolecule localization#GO:0033036;peptide metabolic process#GO:0006518;gene expression#GO:0010467;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;protein processing#GO:0016485;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein localization to organelle#GO:0033365;establishment of protein localization to endoplasmic reticulum#GO:0072599;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;protein localization to endoplasmic reticulum#GO:0070972;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein targeting#GO:0006605;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;establishment of protein localization to organelle#GO:0072594;protein targeting to ER#GO:0045047;protein maturation#GO:0051604;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;cellular macromolecule localization#GO:0070727;signal peptide processing#GO:0006465 membrane protein complex#GO:0098796;peptidase complex#GO:1905368;endoplasmic reticulum protein-containing complex#GO:0140534;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 protease#PC00190;protein modifying enzyme#PC00260 Vasopressin synthesis#P04395>Signal Peptidase#P04589 HELRO|EnsemblGenome=HelroG166199|UniProtKB=T1EXW3 T1EXW3 20201413 PTHR12844:SF42 CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS CONNECTOR ENHANCER OF KSR PROTEIN CNK scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG78521|UniProtKB=T1G3C6 T1G3C6 20215574 PTHR11705:SF91 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B FI01817P-RELATED metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metallocarboxypeptidase activity#GO:0004181;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;carboxypeptidase activity#GO:0004180 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG191065|UniProtKB=T1FSJ9 T1FSJ9 20211796 PTHR22741:SF10 P140CAP/SNIP-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG180798|UniProtKB=T1FGA5 T1FGA5 20207854 PTHR45889:SF8 IG-LIKE DOMAIN-CONTAINING PROTEIN IG-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182404|UniProtKB=T1FI55 T1FI55 20208504 PTHR21669:SF28 CAPZ-INTERACTING PROTEIN AND RELATED PROTEINS YEMANUCLEIN cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;protein-DNA complex organization#GO:0071824;cellular component organization#GO:0016043;cellular process#GO:0009987;protein-containing complex organization#GO:0043933 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG123455|UniProtKB=T1EGX9 T1EGX9 20195829 PTHR46320:SF1 GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1 GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric diester hydrolase activity#GO:0008081;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 organic hydroxy compound metabolic process#GO:1901615;lipid metabolic process#GO:0006629;amine metabolic process#GO:0009308;biogenic amine metabolic process#GO:0006576;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;alcohol metabolic process#GO:0006066;cellular process#GO:0009987;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;nitrogen compound metabolic process#GO:0006807;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 phosphodiesterase#PC00185;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG190387|UniProtKB=T1FRY4 T1FRY4 20211581 PTHR43401:SF2 L-THREONINE 3-DEHYDROGENASE L-THREONINE 3-DEHYDROGENASE dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG91092|UniProtKB=T1G7Z7 T1G7Z7 20217194 PTHR43220:SF18 FAMILY NOT NAMED TRANSMEMBRANE PROTEIN 41B HELRO|EnsemblGenome=HelroG194990|UniProtKB=T1FWM6 T1FWM6 20213221 PTHR45080:SF33 CONTACTIN 5 IG-LIKE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cellular component organization or biogenesis#GO:0071840;synapse organization#GO:0050808;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156;cell junction organization#GO:0034330;cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cellular process#GO:0009987 somatodendritic compartment#GO:0036477;cell body#GO:0044297;neuron projection#GO:0043005;neuronal cell body#GO:0043025;cell projection#GO:0042995;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;plasma membrane#GO:0005886;axon#GO:0030424 HELRO|EnsemblGenome=HelroG160061|UniProtKB=T1EPQ6 T1EPQ6 20198556 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG191887|UniProtKB=T1FTE1 T1FTE1 20212088 PTHR46557:SF1 SERINE/THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10 phosphatase binding#GO:0019902;enzyme binding#GO:0019899;protein binding#GO:0005515;protein phosphatase binding#GO:0019903;binding#GO:0005488 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;protein-DNA complex#GO:0032993;chromosome#GO:0005694;chromatin#GO:0000785;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG108583|UniProtKB=T1EEK6 T1EEK6 20195008 PTHR11635:SF152 CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 kinase modulator#PC00140 Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Cell cycle#P00013>Protein kinase subunit#P00482;GABA-B receptor II signaling#P05731>PKA#P05752;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Enkephalin release#P05913>PKA#P05972;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Transcription regulation by bZIP transcription factor#P00055>PKA#P01384;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Hedgehog signaling pathway#P00025>PKA#P00682;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059;Endothelin signaling pathway#P00019>PKA#P00570 HELRO|EnsemblGenome=HelroG191231|UniProtKB=T1FSR6 T1FSR6 20211863 PTHR24006:SF943 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE PUF cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG107257|UniProtKB=T1EE91 T1EE91 20194893 PTHR24393:SF136 ZINC FINGER PROTEIN LD28458P-RELATED DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG158127|UniProtKB=T1EMJ6 T1EMJ6 20197796 PTHR46246:SF1 GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1 GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG166934|UniProtKB=T1EYR9 T1EYR9 20201719 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167105|UniProtKB=T1EZ10 T1EZ10 20201810 PTHR45713:SF15 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172439|UniProtKB=T1F5C0 T1F5C0 20204019 PTHR24324:SF9 HOMEOBOX PROTEIN HHEX HOMEOBOX DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG116613|UniProtKB=T1EGG5 T1EGG5 20195667 PTHR19237:SF20 NUCLEOBINDIN NUCLEOBINDIN 1 cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG173606|UniProtKB=T1F712 T1F712 20204611 PTHR11927:SF9 GALACTOSIDE 2-L-FUCOSYLTRANSFERASE L-FUCOSYLTRANSFERASE transferase activity#GO:0016740;fucosyltransferase activity#GO:0008417;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein glycosylation#GO:0006486;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycosylation#GO:0070085;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG185032|UniProtKB=T1FMB2 T1FMB2 20209961 PTHR45744:SF2 TYROSINE AMINOTRANSFERASE TYROSINE AMINOTRANSFERASE transaminase#PC00216 Tyrosine biosynthesis#P02784>Aromatic amino acid aminotransferase#P03213 HELRO|EnsemblGenome=HelroG79165|UniProtKB=T1G3L0 T1G3L0 20215658 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG150569|UniProtKB=T1EKG1 T1EKG1 20197061 PTHR43840:SF13 MITOCHONDRIAL METAL TRANSPORTER 1-RELATED CATION EFFLUX PROTEIN CYTOPLASMIC DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG187155|UniProtKB=T1FP73 T1FP73 20210620 PTHR45758:SF20 MITOFERRIN-1-RELATED MITOFERRIN-2 inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;inorganic cation transmembrane transporter activity#GO:0022890;metal ion transmembrane transporter activity#GO:0046873 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;iron ion transmembrane transport#GO:0034755;mitochondrial transport#GO:0006839;localization#GO:0051179;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transport#GO:0006812;iron ion transport#GO:0006826;transition metal ion transport#GO:0000041;monoatomic ion transport#GO:0006811;mitochondrial transmembrane transport#GO:1990542;monoatomic cation transmembrane transport#GO:0098655 envelope#GO:0031975;cytoplasm#GO:0005737;mitochondrial membrane#GO:0031966;intracellular membrane-bounded organelle#GO:0043231;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG159927|UniProtKB=T1EPK4 T1EPK4 20198504 PTHR11003:SF291 POTASSIUM CHANNEL, SUBFAMILY K IP11374P monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG190380|UniProtKB=T1FRY0 T1FRY0 20211577 PTHR46908:SF4 CUBILIN-LIKE PROTEIN TUMOR NECROSIS FACTOR-INDUCIBLE GENE 6 PROTEIN HELRO|EnsemblGenome=HelroG189631|UniProtKB=T1FR78 T1FR78 20211325 PTHR46513:SF13 VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG181687|UniProtKB=T1FH85 T1FH85 20208184 PTHR24088:SF0 28S RIBOSOMAL PROTEIN S17, MITOCHONDRIAL SMALL RIBOSOMAL SUBUNIT PROTEIN US17M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;mitochondrial gene expression#GO:0140053;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;mitochondrial translation#GO:0032543;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;organellar ribosome#GO:0000313;protein-containing complex#GO:0032991;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;small ribosomal subunit#GO:0015935;ribosome#GO:0005840;mitochondrial small ribosomal subunit#GO:0005763;mitochondrial protein-containing complex#GO:0098798 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG181885|UniProtKB=T1FHF4 T1FHF4 20208253 PTHR10075:SF100 BASIGIN RELATED FASCICLIN-2 cell adhesion molecule binding#GO:0050839;cell-cell adhesion mediator activity#GO:0098632;protein binding#GO:0005515;binding#GO:0005488 neuron projection guidance#GO:0097485;cell recognition#GO:0008037;neurogenesis#GO:0022008;cell projection organization#GO:0030030;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;axonogenesis#GO:0007409;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156;cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cell morphogenesis#GO:0000902;cellular process#GO:0009987;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure development#GO:0048856;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;axon#GO:0030424 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG195131|UniProtKB=T1FWS4 T1FWS4 20213269 PTHR19282:SF560 TETRASPANIN BRCT DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG191972|UniProtKB=T1FTH0 T1FTH0 20212117 PTHR15052:SF2 RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;transcription by RNA polymerase III#GO:0006383;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;gene expression#GO:0010467;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;transcription factor TFIIIC complex#GO:0000127 HELRO|EnsemblGenome=HelroG176023|UniProtKB=T1FA13 T1FA13 20205662 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG85381|UniProtKB=T1G5W2 T1G5W2 20216459 PTHR10468:SF0 PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1/ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE acetylglucosaminyltransferase activity#GO:0008375;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG169077|UniProtKB=T1F1D4 T1F1D4 20202634 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174253|UniProtKB=T1F7W2 T1F7W2 20204911 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192078|UniProtKB=T1FTK1 T1FTK1 20212148 PTHR48125:SF12 LP07818P1 AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED Huntington disease#P00029>N-Wasp#P00769;Cytoskeletal regulation by Rho GTPase#P00016>N-WASP#P00525 HELRO|EnsemblGenome=HelroG186169|UniProtKB=T1FNR6 T1FNR6 20210463 PTHR24031:SF421 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX28-RELATED cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;organelle assembly#GO:0070925;protein-RNA complex assembly#GO:0022618;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;ribosomal large subunit assembly#GO:0000027;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;protein-RNA complex organization#GO:0071826;non-membrane-bounded organelle assembly#GO:0140694 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG192560|UniProtKB=T1FU29 T1FU29 20212325 PTHR38537:SF13 JITTERBUG, ISOFORM N JITTERBUG, ISOFORM N HELRO|EnsemblGenome=HelroG75758|UniProtKB=T1G299 T1G299 20215197 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG160118|UniProtKB=T1EPU0 T1EPU0 20198590 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG82533|UniProtKB=T1G4T3 T1G4T3 20216081 PTHR12480:SF21 ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD JMJC DOMAIN-CONTAINING PROTEIN 8 cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG165937|UniProtKB=T1EXH3 T1EXH3 20201273 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG79619|UniProtKB=T1G3R2 T1G3R2 20215710 PTHR43134:SF1 SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoprotein complex binding#GO:0043021;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;protein-containing complex binding#GO:0044877;ribonucleoside triphosphate phosphatase activity#GO:0017111 localization#GO:0051179;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;protein targeting#GO:0006605;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 cellular anatomical entity#GO:0110165;membrane#GO:0016020 G-protein#PC00020 HELRO|EnsemblGenome=HelroG117237|UniProtKB=T1EGL3 T1EGL3 20195713 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG177760|UniProtKB=T1FC75 T1FC75 20206424 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG158927|UniProtKB=T1ENF0 T1ENF0 20198100 PTHR46600:SF1 THAP DOMAIN-CONTAINING THAP DOMAIN-CONTAINING PROTEIN 1 zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG150360|UniProtKB=T1EKF2 T1EKF2 20197052 PTHR22957:SF601 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 30 nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;activation of GTPase activity#GO:0090630;biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG174821|UniProtKB=T1F8I6 T1F8I6 20205135 PTHR10075:SF100 BASIGIN RELATED FASCICLIN-2 cell adhesion molecule binding#GO:0050839;cell-cell adhesion mediator activity#GO:0098632;protein binding#GO:0005515;binding#GO:0005488 neuron projection guidance#GO:0097485;cell recognition#GO:0008037;neurogenesis#GO:0022008;cell projection organization#GO:0030030;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;axonogenesis#GO:0007409;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156;cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cell morphogenesis#GO:0000902;cellular process#GO:0009987;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure development#GO:0048856;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;axon#GO:0030424 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG112159|UniProtKB=T1EFH4 T1EFH4 20195326 PTHR43201:SF8 ACYL-COA SYNTHETASE ACYL-COA SYNTHETASE FAMILY MEMBER 3 ligase activity#GO:0016874;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 lipid metabolic process#GO:0006629;oxoacid metabolic process#GO:0043436;fatty acid metabolic process#GO:0006631;cellular metabolic process#GO:0044237;cellular process#GO:0009987;cellular lipid metabolic process#GO:0044255;organic acid metabolic process#GO:0006082;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ligase#PC00142;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG81131|UniProtKB=T1G499 T1G499 20215897 PTHR11254:SF67 HECT DOMAIN UBIQUITIN-PROTEIN LIGASE E3 UBIQUITIN-PROTEIN LIGASE HUWE1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E3#P01490 HELRO|EnsemblGenome=HelroG181603|UniProtKB=T1FH59 T1FH59 20208158 PTHR48051:SF54 FAMILY NOT NAMED LEUCINE-RICH REPEAT-CONTAINING PROTEIN cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG179951|UniProtKB=T1FFA1 T1FFA1 20207500 PTHR31394:SF1 TRANSMEMBRANE PROTEIN 199 TRANSMEMBRANE PROTEIN 199 cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG109192|UniProtKB=T1EER2 T1EER2 20195064 PTHR39369:SF6 LIN-24 (TWENTY-FOUR) LIKE LIN-24 (TWENTY-FOUR) LIKE HELRO|EnsemblGenome=HelroG173500|UniProtKB=T1F6W5 T1F6W5 20204564 PTHR24637:SF388 COLLAGEN NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171239|UniProtKB=T1F3Z4 T1F3Z4 20203543 PTHR22948:SF29 TUDOR DOMAIN CONTAINING PROTEIN FI02030P-RELATED scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG186274|UniProtKB=T1FNW4 T1FNW4 20210511 PTHR43995:SF1 PRE-MRNA-PROCESSING FACTOR 19 PRE-MRNA-PROCESSING FACTOR 19 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;mRNA splicing, via spliceosome#GO:0000398;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;U2-type spliceosomal complex#GO:0005684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;Prp19 complex#GO:0000974;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 mRNA splicing#P00058>U4#P01476 HELRO|EnsemblGenome=HelroG63358|UniProtKB=T1FXE8 T1FXE8 20213496 PTHR12749:SF0 EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1 DNA EXCISION REPAIR PROTEIN ERCC-1 damaged DNA binding#GO:0003684;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;single-stranded DNA binding#GO:0003697;DNA binding#GO:0003677 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;response to light stimulus#GO:0009416;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;response to stress#GO:0006950;response to UV#GO:0009411;nitrogen compound metabolic process#GO:0006807;response to radiation#GO:0009314;mitotic recombination#GO:0006312;response to abiotic stimulus#GO:0009628;cellular response to stress#GO:0033554;cellular response to light stimulus#GO:0071482;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleotide-excision repair complex#GO:0000109;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 endodeoxyribonuclease#PC00093 HELRO|EnsemblGenome=HelroG123182|UniProtKB=T1EGX2 T1EGX2 20195822 PTHR11929:SF145 ALPHA- 1,3 -FUCOSYLTRANSFERASE ALPHA-(1,3)-FUCOSYLTRANSFERASE FUT-1 transferase activity#GO:0016740;fucosyltransferase activity#GO:0008417;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycosylation#GO:0070085;metabolic process#GO:0008152 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG87923|UniProtKB=T1G6X0 T1G6X0 20216817 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189823|UniProtKB=T1FRE3 T1FRE3 20211390 PTHR23238:SF31 RNA BINDING PROTEIN GH13594P-RELATED molecular adaptor activity#GO:0060090;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;transcription coregulator activity#GO:0003712;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159;protein-macromolecule adaptor activity#GO:0030674 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG160784|UniProtKB=T1EQQ2 T1EQQ2 20198902 PTHR46630:SF1 TETRATRICOPEPTIDE REPEAT PROTEIN 29 TETRATRICOPEPTIDE REPEAT PROTEIN 29 HELRO|EnsemblGenome=HelroG191964|UniProtKB=T1FTG6 T1FTG6 20212113 PTHR12984:SF16 SCY1-RELATED S/T PROTEIN KINASE-LIKE BLACK MATCH, ISOFORM H non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG185279|UniProtKB=T1FML6 T1FML6 20210065 PTHR45721:SF12 LAMIN DM0-RELATED INTERMEDIATE FILAMENT PROTEIN IFA-1 structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;nuclear migration#GO:0007097;cellular localization#GO:0051641;negative regulation of biological process#GO:0048519;protein-DNA complex organization#GO:0071824;organelle localization#GO:0051640;macromolecule localization#GO:0033036;membrane organization#GO:0061024;transport#GO:0006810;protein localization to nucleus#GO:0034504;nucleus organization#GO:0006997;endomembrane system organization#GO:0010256;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;protein localization to organelle#GO:0033365;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;establishment of organelle localization#GO:0051656;negative regulation of cellular process#GO:0048523;localization within membrane#GO:0051668;negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;cellular process#GO:0009987;negative regulation of gene expression, epigenetic#GO:0045814;epigenetic regulation of gene expression#GO:0040029;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular macromolecule localization#GO:0070727;heterochromatin organization#GO:0070828;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;chromatin organization#GO:0006325;intracellular transport#GO:0046907;nuclear envelope organization#GO:0006998;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323;protein-containing complex localization#GO:0031503 membrane-enclosed lumen#GO:0031974;envelope#GO:0031975;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;nuclear periphery#GO:0034399;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981 HELRO|EnsemblGenome=HelroG90782|UniProtKB=T1G7W2 T1G7W2 20217159 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG170151|UniProtKB=T1F2Q1 T1F2Q1 20203100 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG106997|UniProtKB=T1EE65 T1EE65 20194867 PTHR23085:SF16 GH28348P GH28348P intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG190815|UniProtKB=T1FSB3 T1FSB3 20211710 PTHR13167:SF25 PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215 response to external stimulus#GO:0009605;response to stimulus#GO:0050896;detection of mechanical stimulus#GO:0050982;cellular response to stimulus#GO:0051716;response to mechanical stimulus#GO:0009612;regulation of biological quality#GO:0065008;regulation of membrane potential#GO:0042391;biological regulation#GO:0065007;cellular response to external stimulus#GO:0071496;detection of stimulus#GO:0051606;response to abiotic stimulus#GO:0009628;cellular process#GO:0009987 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG185745|UniProtKB=T1FN83 T1FN83 20210281 PTHR11635:SF152 CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 kinase modulator#PC00140 Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Cell cycle#P00013>Protein kinase subunit#P00482;GABA-B receptor II signaling#P05731>PKA#P05752;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Enkephalin release#P05913>PKA#P05972;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Transcription regulation by bZIP transcription factor#P00055>PKA#P01384;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Hedgehog signaling pathway#P00025>PKA#P00682;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059;Endothelin signaling pathway#P00019>PKA#P00570 HELRO|EnsemblGenome=HelroG184942|UniProtKB=T1FM70 T1FM70 20209919 PTHR48082:SF2 ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL monoatomic cation channel activity#GO:0005261;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;inorganic molecular entity transmembrane transporter activity#GO:0015318;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;proton channel activity#GO:0015252;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;ligase activity#GO:0016874;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;ATP binding#GO:0005524;monoatomic ion transmembrane transporter activity#GO:0015075 cellular aromatic compound metabolic process#GO:0006725;ribonucleoside triphosphate metabolic process#GO:0009199;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative metabolic process#GO:1901135;ATP biosynthetic process#GO:0006754;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;purine nucleoside triphosphate biosynthetic process#GO:0009145;heterocycle metabolic process#GO:0046483;purine ribonucleoside triphosphate metabolic process#GO:0009205;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;ribonucleoside triphosphate biosynthetic process#GO:0009201;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;proton motive force-driven ATP synthesis#GO:0015986;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;purine nucleoside triphosphate metabolic process#GO:0009144;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 ATP synthesis#P02721>F1 alpha#P02791 HELRO|EnsemblGenome=HelroG66031|UniProtKB=T1FYG1 T1FYG1 20213859 PTHR15730:SF5 EXPERIMENTAL AUTOIMMUNE PROSTATITIS ANTIGEN 2-RELATED SI:CH211-210B2.2-RELATED HELRO|EnsemblGenome=HelroG111260|UniProtKB=T1EFA0 T1EFA0 20195252 PTHR45670:SF1 E3 UBIQUITIN-PROTEIN LIGASE TRIP12 E3 UBIQUITIN-PROTEIN LIGASE HECTD1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG171586|UniProtKB=T1F4F5 T1F4F5 20203704 PTHR47763:SF1 ALPHA-PROTEIN KINASE VWKA DUF659 DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-serine modification#GO:0018209;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG148584|UniProtKB=T1EKA5 T1EKA5 20197005 PTHR24340:SF41 HOMEOBOX PROTEIN NKX MUSCLE-SPECIFIC HOMEOBOX PROTEIN TINMAN-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG161482|UniProtKB=T1ERJ0 T1ERJ0 20199190 PTHR23004:SF23 DOUBLECORTIN DOMAIN CONTAINING 2 DOUBLECORTIN DOMAIN-CONTAINING PROTEIN supramolecular complex#GO:0099080;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG62048|UniProtKB=T1FWU6 T1FWU6 20213294 PTHR24203:SF45 ANKYRIN REPEAT FAMILY PROTEIN ANKYRIN REPEAT DOMAIN 6 HELRO|EnsemblGenome=HelroG76326|UniProtKB=T1G2I4 T1G2I4 20215282 PTHR10257:SF5 SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B WIDERBORST, ISOFORM H phosphatase regulator activity#GO:0019208;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888 macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;dephosphorylation#GO:0016311;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;protein metabolic process#GO:0019538;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 Wnt signaling pathway#P00057>PP2A#P01438;FGF signaling pathway#P00021>PP2A#P00629;EGF receptor signaling pathway#P00018>PP2A#P00547 HELRO|EnsemblGenome=HelroG178030|UniProtKB=T1FCM8 T1FCM8 20206577 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173392|UniProtKB=T1F6R8 T1F6R8 20204517 PTHR22906:SF43 PROPERDIN PROPERDIN HELRO|EnsemblGenome=HelroG192382|UniProtKB=T1FTW0 T1FTW0 20212257 PTHR45623:SF14 CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1 ATP-dependent activity, acting on DNA#GO:0008094;nucleic acid binding#GO:0003676;binding#GO:0005488;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887;histone binding#GO:0042393;pyrophosphatase activity#GO:0016462;ATP-dependent activity#GO:0140657;chromatin binding#GO:0003682;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity, acting on DNA#GO:0140097;protein-containing complex binding#GO:0044877 cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;nucleosome organization#GO:0034728;protein-containing complex organization#GO:0043933;chromatin organization#GO:0006325;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG88556|UniProtKB=T1G738 T1G738 20216885 PTHR12411:SF1002 CYSTEINE PROTEASE FAMILY C1-RELATED COUNTING FACTOR ASSOCIATED PROTEIN D cysteine-type peptidase activity#GO:0008234;peptidase activator activity#GO:0016504;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197;hydrolase activity#GO:0016787;enzyme activator activity#GO:0008047;peptidase regulator activity#GO:0061134;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;enzyme regulator activity#GO:0030234 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of protein metabolic process#GO:0051246;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of signal transduction#GO:0009967;regulation of signaling#GO:0023051;protein catabolic process#GO:0030163;positive regulation of molecular function#GO:0044093;organonitrogen compound catabolic process#GO:1901565;regulation of catalytic activity#GO:0050790;regulation of apoptotic signaling pathway#GO:2001233;positive regulation of proteolysis#GO:0045862;regulation of biological process#GO:0050789;positive regulation of response to stimulus#GO:0048584;positive regulation of programmed cell death#GO:0043068;positive regulation of metabolic process#GO:0009893;nitrogen compound metabolic process#GO:0006807;regulation of molecular function#GO:0065009;regulation of signal transduction#GO:0009966;proteolysis#GO:0006508;catabolic process#GO:0009056;regulation of hydrolase activity#GO:0051336;positive regulation of apoptotic signaling pathway#GO:2001235;organic substance catabolic process#GO:1901575;positive regulation of signaling#GO:0023056;protein metabolic process#GO:0019538;positive regulation of biological process#GO:0048518;proteolysis involved in protein catabolic process#GO:0051603;positive regulation of peptidase activity#GO:0010952;organic substance metabolic process#GO:0071704;regulation of programmed cell death#GO:0043067;metabolic process#GO:0008152;positive regulation of apoptotic process#GO:0043065;regulation of proteolysis#GO:0030162;regulation of cell communication#GO:0010646;macromolecule catabolic process#GO:0009057;regulation of apoptotic process#GO:0042981;immune response#GO:0006955;positive regulation of catalytic activity#GO:0043085;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of hydrolase activity#GO:0051345;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of response to stimulus#GO:0048583;immune system process#GO:0002376;response to stimulus#GO:0050896;positive regulation of protein metabolic process#GO:0051247;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;biological regulation#GO:0065007;regulation of peptidase activity#GO:0052547;regulation of metabolic process#GO:0019222 cytoplasm#GO:0005737;lysosome#GO:0005764;intracellular membrane-bounded organelle#GO:0043231;extracellular region#GO:0005576;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;organelle#GO:0043226;lytic vacuole#GO:0000323;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG186146|UniProtKB=T1FNQ5 T1FNQ5 20210452 PTHR12317:SF79 DIACYLGLYCEROL O-ACYLTRANSFERASE ACYLTRANSFERASE acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;O-acyltransferase activity#GO:0008374 lipid metabolic process#GO:0006629;triglyceride metabolic process#GO:0006641;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;acylglycerol metabolic process#GO:0006639;lipid biosynthetic process#GO:0008610;primary metabolic process#GO:0044238;neutral lipid metabolic process#GO:0006638;glycerolipid metabolic process#GO:0046486;triglyceride biosynthetic process#GO:0019432;cellular lipid metabolic process#GO:0044255;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG69747|UniProtKB=T1FZY2 T1FZY2 20214380 PTHR22883:SF40 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular localization#GO:0051641;macromolecule localization#GO:0033036;macromolecule modification#GO:0043412;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;protein palmitoylation#GO:0018345;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;localization within membrane#GO:0051668;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein localization to membrane#GO:0072657;organonitrogen compound biosynthetic process#GO:1901566;protein targeting#GO:0006605;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;protein acylation#GO:0043543;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipoprotein biosynthetic process#GO:0042158;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;lipoprotein metabolic process#GO:0042157 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185641|UniProtKB=T1FN29 T1FN29 20210228 PTHR24031:SF84 RNA HELICASE EUKARYOTIC INITIATION FACTOR 4A nucleic acid binding#GO:0003676;translation regulator activity#GO:0045182;translation regulator activity, nucleic acid binding#GO:0090079;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation initiation factor activity#GO:0003743;translation factor activity, RNA binding#GO:0008135 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cytoplasmic translation#GO:0002181;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cytoplasmic translational initiation#GO:0002183;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;translational initiation#GO:0006413;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;cytoplasmic stress granule#GO:0010494;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG86626|UniProtKB=T1G6E5 T1G6E5 20216642 PTHR18945:SF879 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission#GO:0007268;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 cell junction#GO:0030054;synapse#GO:0045202;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;neuron projection#GO:0043005 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG190892|UniProtKB=T1FSE3 T1FSE3 20211740 PTHR15129:SF0 SRC-ASSOCIATED ADAPTOR PROTEIN SH3 DOMAIN-CONTAINING PROTEIN cytoplasm#GO:0005737;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG193018|UniProtKB=T1FUI9 T1FUI9 20212485 PTHR21716:SF4 TRANSMEMBRANE PROTEIN TRANSMEMBRANE PROTEIN 245 HELRO|EnsemblGenome=HelroG194397|UniProtKB=T1FW06 T1FW06 20213002 PTHR11686:SF54 GAMMA GLUTAMYL TRANSPEPTIDASE GLUTATHIONE HYDROLASE 7 hydrolase activity#GO:0016787;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 sulfur compound metabolic process#GO:0006790;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;peptide catabolic process#GO:0043171;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;cellular process#GO:0009987;glutathione metabolic process#GO:0006749;sulfur compound catabolic process#GO:0044273;nitrogen compound metabolic process#GO:0006807;cellular modified amino acid metabolic process#GO:0006575;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG174407|UniProtKB=T1F834 T1F834 20204983 PTHR34396:SF25 OS03G0264950 PROTEIN-RELATED BOUNDARY ELEMENT ASSOCIATED FACTOR sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG133553|UniProtKB=T1EI14 T1EI14 20196214 PTHR20855:SF92 ADIPOR/PROGESTIN RECEPTOR-RELATED PROGESTIN AND ADIPOQ RECEPTOR FAMILY MEMBER 3-LIKE signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG169480|UniProtKB=T1F1Z8 T1F1Z8 20202848 PTHR10877:SF194 POLYCYSTIN FAMILY MEMBER LOCATION OF VULVA DEFECTIVE 1 calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216 detection of stimulus#GO:0051606;response to external stimulus#GO:0009605;response to stimulus#GO:0050896;detection of mechanical stimulus#GO:0050982;response to mechanical stimulus#GO:0009612;response to abiotic stimulus#GO:0009628 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG176284|UniProtKB=T1FAD2 T1FAD2 20205781 PTHR14195:SF2 G PATCH DOMAIN CONTAINING PROTEIN 2 GH10944P membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG70666|UniProtKB=T1G0A2 T1G0A2 20214500 PTHR19290:SF134 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED NEUROGENIC DIFFERENTIATION FACTOR 1 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;neurogenesis#GO:0022008;positive regulation of RNA biosynthetic process#GO:1902680;cell projection organization#GO:0030030;regulation of nitrogen compound metabolic process#GO:0051171;animal organ development#GO:0048513;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;regulation of biological process#GO:0050789;system development#GO:0048731;cell differentiation#GO:0030154;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;neuron differentiation#GO:0030182;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;multicellular organism development#GO:0007275;cellular component organization#GO:0016043;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;anatomical structure development#GO:0048856;biological regulation#GO:0065007;neuron development#GO:0048666;multicellular organismal process#GO:0032501;positive regulation of RNA metabolic process#GO:0051254;generation of neurons#GO:0048699;sensory organ development#GO:0007423;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG174506|UniProtKB=T1F872 T1F872 20205021 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG67865|UniProtKB=T1FZ66 T1FZ66 20214114 PTHR19282:SF452 TETRASPANIN LD03691P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG192478|UniProtKB=T1FU00 T1FU00 20212296 PTHR10411:SF8 GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 FI09246P biological regulation#GO:0065007;regulation of biological process#GO:0050789;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG189618|UniProtKB=T1FR76 T1FR76 20211323 PTHR12411:SF917 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN L cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197 macromolecule catabolic process#GO:0009057;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;proteolysis#GO:0006508;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;catabolic process#GO:0009056;organonitrogen compound catabolic process#GO:1901565;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;lysosome#GO:0005764;intracellular membrane-bounded organelle#GO:0043231;extracellular region#GO:0005576;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;organelle#GO:0043226;lytic vacuole#GO:0000323;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG63503|UniProtKB=T1FXG6 T1FXG6 20213514 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191874|UniProtKB=T1FTD6 T1FTD6 20212083 PTHR15435:SF2 KICSTOR COMPLEX PROTEIN KAPTIN KICSTOR COMPLEX PROTEIN KAPTIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 negative regulation of biological process#GO:0048519;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;response to extracellular stimulus#GO:0009991;regulation of intracellular signal transduction#GO:1902531;negative regulation of TOR signaling#GO:0032007;regulation of biological process#GO:0050789;cellular response to starvation#GO:0009267;regulation of signal transduction#GO:0009966;negative regulation of cell communication#GO:0010648;negative regulation of cellular process#GO:0048523;cellular response to extracellular stimulus#GO:0031668;regulation of cell communication#GO:0010646;cellular response to stimulus#GO:0051716;regulation of TORC1 signaling#GO:1903432;negative regulation of response to stimulus#GO:0048585;negative regulation of signaling#GO:0023057;cell communication#GO:0007154;response to nutrient levels#GO:0031667;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;regulation of response to stimulus#GO:0048583;response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to stress#GO:0006950;cellular response to nutrient levels#GO:0031669;regulation of cellular process#GO:0050794;response to starvation#GO:0042594;biological regulation#GO:0065007;cellular response to external stimulus#GO:0071496;negative regulation of signal transduction#GO:0009968;cellular response to amino acid starvation#GO:0034198;cellular response to stress#GO:0033554;negative regulation of TORC1 signaling#GO:1904262 cell leading edge#GO:0031252;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;plasma membrane bounded cell projection#GO:0120025;lamellipodium#GO:0030027 HELRO|EnsemblGenome=HelroG190660|UniProtKB=T1FS66 T1FS66 20211663 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG183642|UniProtKB=T1FJZ3 T1FJZ3 20209142 PTHR18945:SF865 NEUROTRANSMITTER GATED ION CHANNEL NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA7, ISOFORM E ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG170690|UniProtKB=T1F3B5 T1F3B5 20203314 PTHR21190:SF1 GH10077P GH10077P HELRO|EnsemblGenome=HelroG178863|UniProtKB=T1FDU0 T1FDU0 20206989 PTHR15857:SF0 COMM DOMAIN CONTAINING PROTEIN 2 COMM DOMAIN-CONTAINING PROTEIN 2 HELRO|EnsemblGenome=HelroG162218|UniProtKB=T1ESD2 T1ESD2 20199482 PTHR10283:SF82 SOLUTE CARRIER FAMILY 13 MEMBER SOLUTE CARRIER FAMILY 13 MEMBER 2 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG171410|UniProtKB=T1F489 T1F489 20203638 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166789|UniProtKB=T1EYJ3 T1EYJ3 20201643 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175340|UniProtKB=T1F961 T1F961 20205360 PTHR45929:SF3 JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG175053|UniProtKB=T1F8S5 T1F8S5 20205224 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164223|UniProtKB=T1EV43 T1EV43 20200443 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162832|UniProtKB=T1ET85 T1ET85 20199785 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG92407|UniProtKB=T1G8F7 T1G8F7 20217354 PTHR47573:SF1 PROTEIN AF-9 HOMOLOG PROTEIN AF-9 HOMOLOG HELRO|EnsemblGenome=HelroG170128|UniProtKB=T1F2P3 T1F2P3 20203092 PTHR24408:SF58 ZINC FINGER PROTEIN TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG69793|UniProtKB=T1FZY5 T1FZY5 20214383 PTHR42996:SF1 PHOSPHATE-BINDING PROTEIN PSTS PHOSPHATE-BINDING PROTEIN PSTS ATP-binding cassette (ABC) transporter#PC00003;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG112693|UniProtKB=T1EFL4 T1EFL4 20195366 PTHR11388:SF142 ORGANIC ANION TRANSPORTER SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 5A1 secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;organic substance transport#GO:0071702;establishment of localization#GO:0051234;organic anion transport#GO:0015711;transport#GO:0006810 basal plasma membrane#GO:0009925;basolateral plasma membrane#GO:0016323;plasma membrane region#GO:0098590;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;basal part of cell#GO:0045178;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG172768|UniProtKB=T1F5X0 T1F5X0 20204219 PTHR43250:SF2 EXODEOXYRIBONUCLEASE III EXODEOXYRIBONUCLEASE III HELRO|EnsemblGenome=HelroG191943|UniProtKB=T1FTF6 T1FTF6 20212103 PTHR19321:SF41 PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED FASCETTO-RELATED cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule-based process#GO:0007017;organelle organization#GO:0006996 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;spindle#GO:0005819;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG189004|UniProtKB=T1FQJ9 T1FQJ9 20211096 PTHR31169:SF8 OS05G0300700 PROTEIN ZINC-FINGER DOMAIN OF MONOAMINE-OXIDASE A REPRESSOR R1 PROTEIN membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG126005|UniProtKB=T1EH82 T1EH82 20195932 PTHR48034:SF6 TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED TRANSFORMER-2 SEX-DETERMINING PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 positive regulation of gene expression#GO:0010628;positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of mRNA metabolic process#GO:1903313;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of mRNA processing#GO:0050684;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule biosynthetic process#GO:0010556;regulation of mRNA splicing, via spliceosome#GO:0048024;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG111311|UniProtKB=T1EFA2 T1EFA2 20195254 PTHR24241:SF76 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR NEUROPEPTIDE SIFAMIDE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;binding#GO:0005488;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888;amide binding#GO:0033218 response to organic substance#GO:0010033;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;response to hormone#GO:0009725;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG109396|UniProtKB=T1EET2 T1EET2 20195084 PTHR24014:SF6 2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 2 PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 1, MITOCHONDRIAL RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG190709|UniProtKB=T1FS80 T1FS80 20211677 PTHR42757:SF32 IGLON FAMILY OF IMMUNOGLOBULIN SUPERFAMILY-RELATED PROTEIN AMALGAM defense/immunity protein#PC00090;immunoglobulin#PC00123 HELRO|EnsemblGenome=HelroG79198|UniProtKB=T1G8J4 T1G8J4 20217395 PTHR45810:SF15 HISTONE H3.2 HISTONE H3 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG186283|UniProtKB=T1FNW9 T1FNW9 20210516 PTHR13495:SF0 NEFA-INTERACTING NUCLEAR PROTEIN NIP30 PSME3-INTERACTING PROTEIN membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG191074|UniProtKB=T1FSK3 T1FSK3 20211800 PTHR12133:SF2 TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;macromolecule methylation#GO:0043414;tRNA methylation#GO:0030488;organic cyclic compound metabolic process#GO:1901360;methylation#GO:0032259;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;RNA methylation#GO:0001510;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 methyltransferase complex#GO:0034708;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG173455|UniProtKB=T1F6U9 T1F6U9 20204548 PTHR12352:SF3 SECRETED MODULAR CALCIUM-BINDING PROTEIN NIDOGEN-2 extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG158781|UniProtKB=T1EN92 T1EN92 20198042 PTHR23317:SF76 DEDICATOR OF CYTOKINESIS DOCK LD20667P nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022 HELRO|EnsemblGenome=HelroG63519|UniProtKB=T1FXG8 T1FXG8 20213516 PTHR22957:SF653 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN FI17814P1 nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;activation of GTPase activity#GO:0090630;biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG78102|UniProtKB=T1G378 T1G378 20215526 PTHR10445:SF0 GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2 GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;transcription initiation at RNA polymerase II promoter#GO:0006367;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nucleobase-containing compound biosynthetic process#GO:0034654;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase II, holoenzyme#GO:0016591;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;transcription regulator complex#GO:0005667;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;general transcription factor#PC00259 General transcription regulation#P00023>TFIIFbeta#P00667;Transcription regulation by bZIP transcription factor#P00055>TFIIFbeta#P01396 HELRO|EnsemblGenome=HelroG170931|UniProtKB=T1F3L9 T1F3L9 20203418 PTHR46601:SF1 ULP_PROTEASE DOMAIN-CONTAINING PROTEIN ADF-H DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175643|UniProtKB=T1F9G6 T1F9G6 20205465 PTHR45695:SF15 LEUCOKININ RECEPTOR-RELATED OPSIN RH2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Rhodopsin#P00747 HELRO|EnsemblGenome=HelroG74671|UniProtKB=T1G1T8 T1G1T8 20215036 PTHR12822:SF2 PROTEIN YIPF PROTEIN YIPF cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185675|UniProtKB=O18467 O18467 Hro-nos PTHR12887:SF11 NANOS PROTEIN NANOS HOMOLOG 1 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;cellular process involved in reproduction in multicellular organism#GO:0022412;regulation of nitrogen compound metabolic process#GO:0051171;developmental process#GO:0032502;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;regulation of biosynthetic process#GO:0009889;reproductive process#GO:0022414;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;multicellular organismal reproductive process#GO:0048609;germ cell development#GO:0007281;cellular developmental process#GO:0048869;gamete generation#GO:0007276;negative regulation of biosynthetic process#GO:0009890;multicellular organism reproduction#GO:0032504;oogenesis#GO:0048477;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;cellular process#GO:0009987;negative regulation of nitrogen compound metabolic process#GO:0051172;cell development#GO:0048468;developmental process involved in reproduction#GO:0003006;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of translation#GO:0017148;reproduction#GO:0000003;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of macromolecule metabolic process#GO:0010605;sexual reproduction#GO:0019953;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of translation#GO:0006417;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;perinuclear region of cytoplasm#GO:0048471;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG94589|UniProtKB=T1G919 T1G919 20217566 PTHR42886:SF29 RE40534P-RELATED PUMMELIG, ISOFORM A HELRO|EnsemblGenome=HelroG192456|UniProtKB=T1FTZ5 T1FTZ5 20212292 PTHR22791:SF6 RING-TYPE DOMAIN-CONTAINING PROTEIN RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG184904|UniProtKB=T1FM55 T1FM55 20209904 PTHR19305:SF9 SYNAPTOSOMAL ASSOCIATED PROTEIN SYNAPTOSOMAL-ASSOCIATED PROTEIN 29 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 SNARE protein#PC00034 Opioid proenkephalin pathway#P05915>SNARE Complex#P05986;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066;Thyrotropin-releasing hormone receptor signaling pathway#P04394>SNARE Complex#P04582;Dopamine receptor mediated signaling pathway#P05912>SNARE Complex#P05956;Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072;Beta3 adrenergic receptor signaling pathway#P04379>SNARE Complex#P04447;5HT4 type receptor mediated signaling pathway#P04376>SNARE Complex#P04428;Opioid prodynorphin pathway#P05916>SNARE Complex#P05996;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;5HT3 type receptor mediated signaling pathway#P04375>SNARE Complex#P04423;Ionotropic glutamate receptor pathway#P00037>SNARE Complex#P01013;Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049;Opioid proopiomelanocortin pathway#P05917>SNARE Complex#P06005;Beta1 adrenergic receptor signaling pathway#P04377>SNARE Complex#P04435;Cortocotropin releasing factor receptor signaling pathway#P04380>SNARE Complex#P04457;Metabotropic glutamate receptor group III pathway#P00039>SNARE Complex#P01042;Oxytocin receptor mediated signaling pathway#P04391>SNARE Complex#P04532;5HT2 type receptor mediated signaling pathway#P04374>SNARE Complex#P04415;5HT1 type receptor mediated signaling pathway#P04373>SNARE Complex#P04405;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;Beta2 adrenergic receptor signaling pathway#P04378>SNARE Complex#P04442 HELRO|EnsemblGenome=HelroG157915|UniProtKB=T1EMH7 T1EMH7 20197777 PTHR26312:SF87 TETRATRICOPEPTIDE REPEAT PROTEIN 5 TETRATRICOPEPTIDE REPEAT PROTEIN 5 HELRO|EnsemblGenome=HelroG124980|UniProtKB=T1EH37 T1EH37 20195887 PTHR13308:SF40 NEDD4-BINDING PROTEIN 2-LIKE 1 NEDD4-BINDING PROTEIN 2-LIKE 1 HELRO|EnsemblGenome=HelroG135734|UniProtKB=T1EIA2 T1EIA2 20196302 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG156513|UniProtKB=T1ELX9 T1ELX9 20197579 PTHR22780:SF4 ADAPTIN, ALPHA/GAMMA/EPSILON AP-2 COMPLEX SUBUNIT ALPHA molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 localization#GO:0051179;establishment of localization#GO:0051234;clathrin-dependent endocytosis#GO:0072583;transport#GO:0006810;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;receptor-mediated endocytosis#GO:0006898;cellular process#GO:0009987;import into cell#GO:0098657 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;plasma membrane protein complex#GO:0098797;clathrin vesicle coat#GO:0030125;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;vesicle coat#GO:0030120;intracellular anatomical structure#GO:0005622;AP-type membrane coat adaptor complex#GO:0030119;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;clathrin-coated vesicle#GO:0030136;endomembrane system#GO:0012505;membrane coat#GO:0030117;coated vesicle membrane#GO:0030662;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;coated membrane#GO:0048475;endocytic vesicle#GO:0030139;cytoplasmic vesicle membrane#GO:0030659;clathrin-coated pit#GO:0005905;plasma membrane#GO:0005886 membrane traffic protein#PC00150 Huntington disease#P00029>alpha-Adaptin#P00782 HELRO|EnsemblGenome=HelroG186523|UniProtKB=T1FP04 T1FP04 20210551 PTHR10906:SF1 SECY/SEC61-ALPHA FAMILY MEMBER DSEC61ALPHA signal sequence binding#GO:0005048;protein transmembrane transporter activity#GO:0008320;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;binding#GO:0005488;amide binding#GO:0033218;peptide binding#GO:0042277 localization within membrane#GO:0051668;cotranslational protein targeting to membrane#GO:0006613;cellular localization#GO:0051641;intracellular protein transmembrane transport#GO:0065002;protein localization to endoplasmic reticulum#GO:0070972;transmembrane transport#GO:0055085;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;transport#GO:0006810;protein transmembrane transport#GO:0071806;protein targeting#GO:0006605;nitrogen compound transport#GO:0071705;protein targeting to ER#GO:0045047;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;SRP-dependent cotranslational protein targeting to membrane#GO:0006614;organic substance transport#GO:0071702;establishment of protein localization to membrane#GO:0090150;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365;establishment of protein localization to endoplasmic reticulum#GO:0072599 transporter#PC00227 HELRO|EnsemblGenome=HelroG98522|UniProtKB=T1G9N4 T1G9N4 20217780 PTHR10514:SF27 ANGIOTENSIN-CONVERTING ENZYME ANGIOTENSIN-CONVERTING ENZYME metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG106160|UniProtKB=T1EE06 T1EE06 20194808 PTHR14102:SF11 PAR-6-RELATED LD29223P cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;microtubule cytoskeleton organization#GO:0000226;centrosome cycle#GO:0007098;cell cycle process#GO:0022402;cell cycle#GO:0007049;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule organizing center organization#GO:0031023 tight junction#PC00214 HELRO|EnsemblGenome=HelroG194586|UniProtKB=T1FW82 T1FW82 20213078 PTHR12424:SF8 TWEETY-RELATED PROTEIN TWEETY inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG66873|UniProtKB=T1FYS2 T1FYS2 20213970 PTHR15454:SF73 NISCHARIN RELATED DYNEIN AXONEMAL LIGHT CHAIN 1 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG164476|UniProtKB=T1EVH1 T1EVH1 20200571 PTHR34203:SF15 METHYLTRANSFERASE, FKBM FAMILY PROTEIN SLL1173 PROTEIN methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG161703|UniProtKB=T1ERS9 T1ERS9 20199279 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG76748|UniProtKB=T1G2N9 T1G2N9 20215337 PTHR21052:SF0 SPERMATOGENESIS ASSOCIATED 11-RELATED ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL HELRO|EnsemblGenome=HelroG160696|UniProtKB=T1EQM1 T1EQM1 20198871 PTHR19303:SF71 TRANSPOSON ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG185773|UniProtKB=T1FN98 T1FN98 20210296 PTHR11540:SF16 MALATE AND LACTATE DEHYDROGENASE MALATE DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 Pyruvate metabolism#P02772>Lactate Dehydrogenase#P03139 HELRO|EnsemblGenome=HelroG176901|UniProtKB=T1FB13 T1FB13 20206012 PTHR16021:SF23 MANSC DOMAIN CONTAINING PROTEIN 1 FI18411P1-RELATED HELRO|EnsemblGenome=HelroG173612|UniProtKB=T1F718 T1F718 20204617 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG166424|UniProtKB=T1EY44 T1EY44 20201494 PTHR46647:SF1 RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS HELRO|EnsemblGenome=HelroG185978|UniProtKB=T1FNI3 T1FNI3 20210380 PTHR11353:SF21 CHAPERONIN CHAPERONIN CONTAINING TCP1 SUBUNIT 6A-RELATED protein binding#GO:0005515;unfolded protein binding#GO:0051082;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;chaperonin-containing T-complex#GO:0005832;protein folding chaperone complex#GO:0101031;intracellular anatomical structure#GO:0005622 chaperonin#PC00073 HELRO|EnsemblGenome=HelroG185916|UniProtKB=T1FNF7 T1FNF7 20210354 PTHR10621:SF0 UV EXCISION REPAIR PROTEIN RAD23 UV EXCISION REPAIR PROTEIN RAD23 proteasome binding#GO:0070628;ubiquitin-like protein binding#GO:0032182;binding#GO:0005488;ubiquitin binding#GO:0043130;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;modification-dependent protein binding#GO:0140030;polyubiquitin modification-dependent protein binding#GO:0031593 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 damaged DNA-binding protein#PC00086;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG193843|UniProtKB=T1FVE9 T1FVE9 20212795 PTHR19960:SF25 TEKTIN TEKTIN-1 cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cilium or flagellum-dependent cell motility#GO:0001539;cell motility#GO:0048870;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;cilium movement involved in cell motility#GO:0060294;cilium movement#GO:0003341;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cilium-dependent cell motility#GO:0060285;microtubule-based process#GO:0007017;organelle organization#GO:0006996;plasma membrane bounded cell projection assembly#GO:0120031 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG192833|UniProtKB=T1FUC3 T1FUC3 20212419 PTHR12287:SF23 EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN AROUSER, ISOFORM A-RELATED cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;actin binding#GO:0003779;binding#GO:0005488 regulation of cell communication#GO:0010646;regulation of Rho protein signal transduction#GO:0035023;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;small GTPase-mediated signal transduction#GO:0007264;regulation of signaling#GO:0023051;cell communication#GO:0007154;cellular process#GO:0009987;regulation of intracellular signal transduction#GO:1902531;Rho protein signal transduction#GO:0007266;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;intracellular signal transduction#GO:0035556;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG183880|UniProtKB=T1FKA2 T1FKA2 20209251 PTHR12963:SF4 THYROID RECEPTOR INTERACTING PROTEIN RELATED ACTIVATING SIGNAL COINTEGRATOR 1 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG81330|UniProtKB=T1G4D1 T1G4D1 20215929 PTHR12718:SF2 CELL CYCLE CONTROL PROTEIN CWF15 SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;mRNA cis splicing, via spliceosome#GO:0045292;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;catalytic step 2 spliceosome#GO:0071013;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG159790|UniProtKB=T1EPE7 T1EPE7 20198447 PTHR23048:SF49 MYOSIN LIGHT CHAIN 1, 3 FI08416P-RELATED intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;myosin complex#GO:0016459;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG166689|UniProtKB=T1EYD3 T1EYD3 20201583 PTHR23287:SF16 RUBY-EYE2-LIKE PROTEIN TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 2 HELRO|EnsemblGenome=HelroG191152|UniProtKB=T1FSN5 T1FSN5 20211832 PTHR24270:SF61 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 apolipoprotein#PC00052 HELRO|EnsemblGenome=HelroG189970|UniProtKB=T1FRJ7 T1FRJ7 20211444 PTHR31780:SF10 STRESS RESPONSE PROTEIN NST1-RELATED LD36051P HELRO|EnsemblGenome=HelroG113718|UniProtKB=T1EFV6 T1EFV6 20195458 PTHR14493:SF50 UNKEMPT FAMILY MEMBER RING FINGER PROTEIN UNKEMPT HELRO|EnsemblGenome=HelroG172102|UniProtKB=T1F511 T1F511 20203910 PTHR21676:SF6 PROTEIN STUM PROTEIN STUM HELRO|EnsemblGenome=HelroG78329|UniProtKB=T1G3A7 T1G3A7 20215555 PTHR11453:SF36 ANION EXCHANGE PROTEIN ANION EXCHANGE PROTEIN secondary active transmembrane transporter activity#GO:0015291;inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;symporter activity#GO:0015293;active monoatomic ion transmembrane transporter activity#GO:0022853;solute:sodium symporter activity#GO:0015370;organic anion transmembrane transporter activity#GO:0008514;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;inorganic cation transmembrane transporter activity#GO:0022890;transporter activity#GO:0005215;solute:monoatomic cation symporter activity#GO:0015294 regulation of intracellular pH#GO:0051453;transmembrane transport#GO:0055085;organic anion transport#GO:0015711;transport#GO:0006810;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;regulation of pH#GO:0006885;organic substance transport#GO:0071702;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;intracellular monoatomic cation homeostasis#GO:0030003;biological regulation#GO:0065007;intracellular monoatomic ion homeostasis#GO:0006873;regulation of cellular pH#GO:0030641 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG194114|UniProtKB=T1FVP7 T1FVP7 20212893 PTHR21373:SF0 GLUCOSE REPRESSIBLE PROTEIN MAK10 N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG187664|UniProtKB=T1FPB7 T1FPB7 20210664 PTHR22883:SF147 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular localization#GO:0051641;macromolecule localization#GO:0033036;macromolecule modification#GO:0043412;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;protein palmitoylation#GO:0018345;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;localization within membrane#GO:0051668;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein localization to membrane#GO:0072657;organonitrogen compound biosynthetic process#GO:1901566;protein targeting#GO:0006605;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;protein acylation#GO:0043543;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipoprotein biosynthetic process#GO:0042158;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;lipoprotein metabolic process#GO:0042157 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG159777|UniProtKB=T1EPE3 T1EPE3 20198443 PTHR46025:SF3 XYLOSYLTRANSFERASE OXT XYLOSYLTRANSFERASE OXT transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG170959|UniProtKB=T1F3M5 T1F3M5 20203424 PTHR24416:SF600 TYROSINE-PROTEIN KINASE RECEPTOR PDGF- AND VEGF-RECEPTOR RELATED, ISOFORM J signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG68917|UniProtKB=T1FZL3 T1FZL3 20214261 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG175436|UniProtKB=T1F994 T1F994 20205393 PTHR31186:SF1 MODULATOR OF SMOOTHENED PROTEIN MODULATOR OF SMOOTHENED PROTEIN regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of cellular process#GO:0048523;negative regulation of cell communication#GO:0010648 bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;ciliary membrane#GO:0060170;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;cell projection membrane#GO:0031253;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;plasma membrane region#GO:0098590;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cilium#GO:0005929;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG187984|UniProtKB=T1FPI8 T1FPI8 20210735 PTHR24026:SF133 FAT ATYPICAL CADHERIN-RELATED CADHERIN-RELATED FAMILY MEMBER 2 cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HELRO|EnsemblGenome=HelroG189237|UniProtKB=T1FQU6 T1FQU6 20211193 PTHR21284:SF12 EG:80H7.2 PROTEIN EG:80H7.2 PROTEIN HELRO|EnsemblGenome=HelroG185083|UniProtKB=T1FMD6 T1FMD6 20209985 PTHR46857:SF2 EPITHELIAL CELL-TRANSFORMING SEQUENCE 2 ONCOGENE-LIKE F-BOX ONLY PROTEIN 16 HELRO|EnsemblGenome=HelroG159119|UniProtKB=T1ENM3 T1ENM3 20198173 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG170068|UniProtKB=T1F2L6 T1F2L6 20203065 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG83507|UniProtKB=T1G565 T1G565 20216213 PTHR43344:SF2 PHOSPHOSERINE PHOSPHATASE PHOSPHOSERINE PHOSPHATASE cation binding#GO:0043169;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;magnesium ion binding#GO:0000287;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;metal ion binding#GO:0046872;ion binding#GO:0043167;phosphoric ester hydrolase activity#GO:0042578 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;proteinogenic amino acid biosynthetic process#GO:0170038;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;phosphorus metabolic process#GO:0006793;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;alpha-amino acid biosynthetic process#GO:1901607;nitrogen compound metabolic process#GO:0006807;dephosphorylation#GO:0016311;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;small molecule biosynthetic process#GO:0044283;L-amino acid biosynthetic process#GO:0170034;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 phosphatase#PC00181;hydrolase#PC00121 Serine glycine biosynthesis#P02776>Phosphoserine phosphatase#P03159 HELRO|EnsemblGenome=HelroG97558|UniProtKB=T1G9H6 T1G9H6 20217723 PTHR24006:SF644 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7 cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;regulation of protein stability#GO:0031647;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;regulation of biological quality#GO:0065008;nitrogen compound metabolic process#GO:0006807;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;biological regulation#GO:0065007;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG167922|UniProtKB=T1EZY8 T1EZY8 20202138 PTHR10642:SF26 RIBONUCLEASE H1 RIBONUCLEASE H1 catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular nitrogen compound catabolic process#GO:0044270;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic cyclic compound catabolic process#GO:1901361;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;organic substance catabolic process#GO:1901575;nucleobase-containing compound catabolic process#GO:0034655;DNA replication#GO:0006260;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;cellular catabolic process#GO:0044248 endoribonuclease#PC00094;RNA metabolism protein#PC00031 DNA replication#P00017>RNase H#P00538 HELRO|EnsemblGenome=HelroG106328|UniProtKB=T1EE20 T1EE20 20194822 PTHR14963:SF1 RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED RHO GTPASE-ACTIVATING PROTEIN CONUNDRUM nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of anatomical structure size#GO:0090066;regulation of cell communication#GO:0010646;regulation of actin filament length#GO:0030832;regulation of organelle organization#GO:0033043;regulation of signaling#GO:0023051;regulation of actin filament organization#GO:0110053;regulation of cellular component organization#GO:0051128;cellular component organization#GO:0016043;regulation of actin polymerization or depolymerization#GO:0008064;cellular process#GO:0009987;regulation of intracellular signal transduction#GO:1902531;regulation of actin filament polymerization#GO:0030833;regulation of cellular component size#GO:0032535;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of supramolecular fiber organization#GO:1902903;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cytoskeleton organization#GO:0051493;regulation of protein-containing complex assembly#GO:0043254;regulation of biological quality#GO:0065008;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament-based process#GO:0032970;regulation of protein polymerization#GO:0032271 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG83631|UniProtKB=T1G584 T1G584 20216231 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;chloride transmembrane transporter activity#GO:0015108;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;inorganic anion transmembrane transport#GO:0098661;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic anion transport#GO:0006820;chloride transport#GO:0006821;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;inorganic anion transport#GO:0015698 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG184377|UniProtKB=T1FL31 T1FL31 20209530 PTHR24139:SF34 CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;phospholipase A2 activity#GO:0004623;fatty acyl-CoA hydrolase activity#GO:0047617;catalytic activity#GO:0003824;thiolester hydrolase activity#GO:0016790;hydrolase activity#GO:0016787;phospholipase activity#GO:0004620 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of lipid metabolic process#GO:0019216;regulation of lipid biosynthetic process#GO:0046890;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 phospholipase#PC00186 Gonadotropin-releasing hormone receptor pathway#P06664>PLA2#P06738 HELRO|EnsemblGenome=HelroG175050|UniProtKB=T1F8S4 T1F8S4 20205223 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177753|UniProtKB=T1FC71 T1FC71 20206420 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG154688|UniProtKB=T1ELF6 T1ELF6 PTHR11214:SF219 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE UDP-GALNAC:BETA-1,3-N-ACETYLGALACTOSAMINYLTRANSFERASE 2 transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG161685|UniProtKB=T1ERS5 T1ERS5 20199275 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG172083|UniProtKB=T1F505 T1F505 20203904 PTHR15673:SF2 IQ CALMODULIN-BINDING MOTIF CONTAINING PROTEIN 1 IQ CALMODULIN-BINDING MOTIF-CONTAINING PROTEIN 1 organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG177907|UniProtKB=T1FCG4 T1FCG4 20206513 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG90685|UniProtKB=T1G7U4 T1G7U4 20217141 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185175|UniProtKB=T1FMH0 T1FMH0 20210019 PTHR24031:SF727 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX47-RELATED RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG81089|UniProtKB=T1G489 T1G489 20215887 PTHR12050:SF0 LEPTIN RECEPTOR-RELATED RH04491P localization#GO:0051179;endosomal transport#GO:0016197;cellular localization#GO:0051641;establishment of localization#GO:0051234;vacuolar transport#GO:0007034;transport#GO:0006810;endosome transport via multivesicular body sorting pathway#GO:0032509;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;late endosome to vacuole transport#GO:0045324;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG194664|UniProtKB=T1FWA5 T1FWA5 20213101 PTHR21646:SF46 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG94350|UniProtKB=T1G904 T1G904 20217551 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG167113|UniProtKB=T1EZ13 T1EZ13 20201813 PTHR46679:SF1 FAMILY NOT NAMED GLUTAREDOXIN-2, MITOCHONDRIAL protein-disulfide reductase activity#GO:0015035;disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG88492|UniProtKB=T1G733 T1G733 20216880 PTHR12914:SF2 PARTNER OF SLD5 DNA REPLICATION COMPLEX GINS PROTEIN PSF1 cellular aromatic compound metabolic process#GO:0006725;nuclear DNA replication#GO:0033260;heterocycle metabolic process#GO:0046483;macromolecule metabolic process#GO:0043170;cell cycle process#GO:0022402;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;mitotic cell cycle process#GO:1903047;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mitotic cell cycle#GO:0000278;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mitotic DNA replication#GO:1902969;DNA-templated DNA replication#GO:0006261;cell cycle#GO:0007049;DNA replication#GO:0006260;DNA strand elongation involved in DNA replication#GO:0006271;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;cell cycle DNA replication#GO:0044786 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;DNA replication preinitiation complex#GO:0031261;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;GINS complex#GO:0000811;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG185263|UniProtKB=T1FMK8 T1FMK8 20210057 PTHR44140:SF2 LD25575P LD25575P protein binding#GO:0005515;protein-folding chaperone binding#GO:0051087;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG170819|UniProtKB=T1F3G9 T1F3G9 20203368 PTHR16008:SF4 F-BOX ONLY PROTEIN 4 F-BOX ONLY PROTEIN 4 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234 HELRO|EnsemblGenome=HelroG100094|UniProtKB=T1ECY6 T1ECY6 20194438 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;chloride transmembrane transporter activity#GO:0015108;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;inorganic anion transmembrane transport#GO:0098661;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic anion transport#GO:0006820;chloride transport#GO:0006821;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;inorganic anion transport#GO:0015698 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG189721|UniProtKB=T1FRA6 T1FRA6 20211353 PTHR22692:SF33 MYOSIN VII, XV MYOSIN actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG193196|UniProtKB=T1FUQ7 T1FUQ7 20212553 PTHR44163:SF1 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;t-UTP complex#GO:0034455;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981;90S preribosome#GO:0030686;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG159623|UniProtKB=T1EP92 T1EP92 20198392 PTHR23024:SF574 ARYLACETAMIDE DEACETYLASE KYNURENINE FORMAMIDASE deacetylase#PC00087;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG113446|UniProtKB=T1EFS6 T1EFS6 20195428 PTHR12202:SF0 ESF1 HOMOLOG ESF1 HOMOLOG nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 HELRO|EnsemblGenome=HelroG156685|UniProtKB=T1EM00 T1EM00 20197600 PTHR43108:SF16 N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER EXTRACELLULAR SULFATASE SULF-1 HOMOLOG hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;carbohydrate derivative binding#GO:0097367;glycosaminoglycan binding#GO:0005539;binding#GO:0005488;catalytic activity#GO:0003824 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG161089|UniProtKB=T1ER33 T1ER33 20199033 PTHR11902:SF1 ENOLASE ENOLASE lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;ribonucleoside triphosphate metabolic process#GO:0009199;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative metabolic process#GO:1901135;heterocycle catabolic process#GO:0046700;organonitrogen compound catabolic process#GO:1901565;ribonucleotide catabolic process#GO:0009261;pyridine nucleotide metabolic process#GO:0019362;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;cellular nitrogen compound catabolic process#GO:0044270;purine-containing compound catabolic process#GO:0072523;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;purine nucleotide catabolic process#GO:0006195;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;purine ribonucleotide catabolic process#GO:0009154;nucleoside phosphate metabolic process#GO:0006753;carbohydrate catabolic process#GO:0016052;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;catabolic process#GO:0009056;nucleoside diphosphate metabolic process#GO:0009132;organic substance catabolic process#GO:1901575;carbohydrate metabolic process#GO:0005975;purine nucleotide metabolic process#GO:0006163;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;oxoacid metabolic process#GO:0043436;nucleoside phosphate catabolic process#GO:1901292;carbohydrate derivative catabolic process#GO:1901136;purine ribonucleoside triphosphate metabolic process#GO:0009205;generation of precursor metabolites and energy#GO:0006091;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;nucleotide catabolic process#GO:0009166;cellular nitrogen compound metabolic process#GO:0034641;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;nucleoside diphosphate catabolic process#GO:0009134;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;organophosphate catabolic process#GO:0046434;aromatic compound catabolic process#GO:0019439;glycolytic process#GO:0006096;organic cyclic compound catabolic process#GO:1901361;organophosphate metabolic process#GO:0019637;purine nucleoside triphosphate metabolic process#GO:0009144;nucleobase-containing compound catabolic process#GO:0034655;nucleotide metabolic process#GO:0009117;carboxylic acid metabolic process#GO:0019752;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 lyase#PC00144 Glycolysis#P00024>Enolase#P00678 HELRO|EnsemblGenome=HelroG80673|UniProtKB=T1G438 T1G438 20215836 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG188571|UniProtKB=T1FQ49 T1FQ49 20210946 PTHR11388:SF142 ORGANIC ANION TRANSPORTER SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 5A1 secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;organic substance transport#GO:0071702;establishment of localization#GO:0051234;organic anion transport#GO:0015711;transport#GO:0006810 basal plasma membrane#GO:0009925;basolateral plasma membrane#GO:0016323;plasma membrane region#GO:0098590;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;basal part of cell#GO:0045178;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG168858|UniProtKB=T1F119 T1F119 20202519 PTHR24182:SF13 ANKYRIN REPEAT AND SOCS BOX CONTAINING 4 LD18443P HELRO|EnsemblGenome=HelroG189263|UniProtKB=T1FQW0 T1FQW0 20211207 PTHR12461:SF105 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG169900|UniProtKB=T1F2F3 T1F2F3 20203003 PTHR24388:SF79 ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG181966|UniProtKB=T1FHJ2 T1FHJ2 20208291 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG172150|UniProtKB=T1F525 T1F525 20203924 PTHR24369:SF210 ANTIGEN BSP, PUTATIVE-RELATED CHAOPTIN-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG113741|UniProtKB=T1EFV8 T1EFV8 20195460 PTHR10797:SF0 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT POLY(A)-SPECIFIC RIBONUCLEASE catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787;3'-5'-RNA exonuclease activity#GO:0000175;3'-5' exonuclease activity#GO:0008408;exonuclease activity#GO:0004527;RNA nuclease activity#GO:0004540 negative regulation of gene expression#GO:0010629;regulation of catabolic process#GO:0009894;heterocycle catabolic process#GO:0046700;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;nucleobase-containing compound metabolic process#GO:0006139;RNA destabilization#GO:0050779;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;regulation of biological quality#GO:0065008;nitrogen compound metabolic process#GO:0006807;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;positive regulation of mRNA catabolic process#GO:0061014;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of catabolic process#GO:0009896;mRNA destabilization#GO:0061157;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323;positive regulation of nitrogen compound metabolic process#GO:0051173;cellular aromatic compound metabolic process#GO:0006725;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;RNA metabolic process#GO:0016070;positive regulation of cellular catabolic process#GO:0031331;cellular nitrogen compound catabolic process#GO:0044270;organic cyclic compound metabolic process#GO:1901360;positive regulation of metabolic process#GO:0009893;mRNA catabolic process#GO:0006402;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;positive regulation of mRNA metabolic process#GO:1903313;heterocycle metabolic process#GO:0046483;negative regulation of biosynthetic process#GO:0009890;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of cellular catabolic process#GO:0031329;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;positive regulation of RNA metabolic process#GO:0051254 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;protein-containing complex#GO:0032991;P-body#GO:0000932;CCR4-NOT complex#GO:0030014;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG161600|UniProtKB=T1ERP3 T1ERP3 20199243 PTHR10336:SF80 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN C2 DOMAIN-CONTAINING PROTEIN hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phospholipase C activity#GO:0004629;phospholipase activity#GO:0004620;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578 lipid metabolic process#GO:0006629;signal transduction#GO:0007165;negative regulation of biological process#GO:0048519;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of sequestering of calcium ion#GO:0051282;regulation of localization#GO:0032879;inorganic ion transmembrane transport#GO:0098660;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;calcium ion transport#GO:0006816;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;glycerolipid metabolic process#GO:0046486;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;intracellular signal transduction#GO:0035556;signaling#GO:0023052;negative regulation of cellular process#GO:0048523;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular response to stimulus#GO:0051716;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;cellular metabolic process#GO:0044237;release of sequestered calcium ion into cytosol#GO:0051209;cell communication#GO:0007154;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;cellular process#GO:0009987;primary metabolic process#GO:0044238;localization#GO:0051179;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;calcium ion transmembrane import into cytosol#GO:0097553;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;monoatomic ion transport#GO:0006811;cellular lipid metabolic process#GO:0044255;negative regulation of sequestering of calcium ion#GO:0051283;monoatomic cation transmembrane transport#GO:0098655 phospholipase#PC00186 HELRO|EnsemblGenome=HelroG181683|UniProtKB=T1FH84 T1FH84 20208183 PTHR11534:SF9 MYOGENIC FACTOR MYOGENIC-DETERMINATION PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of cell differentiation#GO:0045597;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of cell differentiation#GO:0045595;positive regulation of developmental process#GO:0051094;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG111479|UniProtKB=T1EFB8 T1EFB8 20195270 PTHR24292:SF54 CYTOCHROME P450 CYP9F3-RELATED oxygenase#PC00177 HELRO|EnsemblGenome=HelroG167516|UniProtKB=T1EZG0 T1EZG0 20201960 PTHR13593:SF113 FAMILY NOT NAMED SI:DKEY-266F7.9 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric diester hydrolase activity#GO:0008081;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 HELRO|EnsemblGenome=HelroG176424|UniProtKB=T1FAH8 T1FAH8 20205827 PTHR13479:SF66 30S RIBOSOMAL PROTEIN S18 LARGE RIBOSOMAL SUBUNIT PROTEIN ML66 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;rRNA binding#GO:0019843;binding#GO:0005488;organic cyclic compound binding#GO:0097159 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;mitochondrial gene expression#GO:0140053;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;mitochondrial translation#GO:0032543;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;organellar ribosome#GO:0000313;protein-containing complex#GO:0032991;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;small ribosomal subunit#GO:0015935;ribosome#GO:0005840;mitochondrial small ribosomal subunit#GO:0005763;mitochondrial protein-containing complex#GO:0098798 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG183618|UniProtKB=T1FJY0 T1FJY0 20209129 PTHR47160:SF10 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG89153|UniProtKB=T1G792 T1G792 20216939 PTHR18919:SF156 ACETYL-COA C-ACYLTRANSFERASE ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;lipid oxidation#GO:0034440;cellular metabolic process#GO:0044237;lipid catabolic process#GO:0016042;lipid modification#GO:0030258;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;fatty acid catabolic process#GO:0009062;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;fatty acid metabolic process#GO:0006631;small molecule catabolic process#GO:0044282;fatty acid beta-oxidation#GO:0006635;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;carboxylic acid metabolic process#GO:0019752;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 acyltransferase#PC00042 CCKR signaling map#P06959>ACAT1#G07285;CCKR signaling map#P06959>ACAT1#G06992 HELRO|EnsemblGenome=HelroG192724|UniProtKB=T1FU82 T1FU82 20212378 PTHR44662:SF1 WD REPEAT-CONTAINING PROTEIN 81 WD REPEAT-CONTAINING PROTEIN 81 HELRO|EnsemblGenome=HelroG178963|UniProtKB=T1FDZ3 T1FDZ3 20207042 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG114796|UniProtKB=T1EG45 T1EG45 20195547 PTHR14289:SF16 F-BOX ONLY PROTEIN 3 POLYMERASE DELTA-INTERACTING PROTEIN 2 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;postreplication repair#GO:0006301;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;translesion synthesis#GO:0019985;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;nucleobase-containing compound biosynthetic process#GO:0034654;DNA biosynthetic process#GO:0071897;DNA synthesis involved in DNA repair#GO:0000731;aromatic compound biosynthetic process#GO:0019438;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259 HELRO|EnsemblGenome=HelroG153336|UniProtKB=T1EL41 T1EL41 20197291 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158794|UniProtKB=T1EN98 T1EN98 20198048 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG115846|UniProtKB=T1EGB3 T1EGB3 20195615 PTHR24192:SF3 ANKYRIN REPEAT DOMAIN 40 ANKYRIN REPEAT DOMAIN 40 HELRO|EnsemblGenome=HelroG155612|UniProtKB=T1ELJ7 T1ELJ7 20197447 PTHR23073:SF31 26S PROTEASOME REGULATORY SUBUNIT 26S PROTEASOME REGULATORY SUBUNIT 10B ATP-dependent activity#GO:0140657 regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;protein catabolic process#GO:0030163;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of cellular component organization#GO:0051128;regulation of RNA biosynthetic process#GO:2001141;modification-dependent macromolecule catabolic process#GO:0043632;regulation of biological process#GO:0050789;nitrogen compound metabolic process#GO:0006807;regulation of cellular component biogenesis#GO:0044087;proteolysis#GO:0006508;proteasomal protein catabolic process#GO:0010498;positive regulation of biological process#GO:0048518;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;response to endoplasmic reticulum stress#GO:0034976;macromolecule metabolic process#GO:0043170;ERAD pathway#GO:0036503;response to organonitrogen compound#GO:0010243;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;ubiquitin-dependent protein catabolic process#GO:0006511;response to nitrogen compound#GO:1901698;response to stress#GO:0006950;regulation of cellular process#GO:0050794;cellular response to stress#GO:0033554;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of transcription by RNA polymerase II#GO:0006357;organonitrogen compound catabolic process#GO:1901565;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of protein-containing complex assembly#GO:0043254;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;catabolic process#GO:0009056;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular component biogenesis#GO:0044089;protein metabolic process#GO:0019538;metabolic process#GO:0008152;response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;regulation of DNA-templated transcription#GO:0006355;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;organonitrogen compound metabolic process#GO:1901564;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;regulation of cellular biosynthetic process#GO:0031326;response to chemical#GO:0042221;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;positive regulation of RNA metabolic process#GO:0051254 cytoplasm#GO:0005737;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;proteasome accessory complex#GO:0022624;proteasome regulatory particle#GO:0005838;catalytic complex#GO:1902494;endopeptidase complex#GO:1905369;proteasome complex#GO:0000502;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 protease#PC00190;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG188840|UniProtKB=T1FQE9 T1FQE9 20211046 PTHR13793:SF107 PHD FINGER PROTEINS BROMODOMAIN-CONTAINING PROTEIN HOMOLOG regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG168055|UniProtKB=T1F043 T1F043 20202193 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG116949|UniProtKB=T1EGI6 T1EGI6 20195688 PTHR19969:SF5 SH2-SH3 ADAPTOR PROTEIN-RELATED CRK-LIKE PROTEIN molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;enzyme binding#GO:0019899;protein binding#GO:0005515;protein kinase binding#GO:0019901;protein tyrosine kinase binding#GO:1990782;receptor tyrosine kinase binding#GO:0030971;signaling receptor binding#GO:0005102;kinase binding#GO:0019900 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;cell communication#GO:0007154;cell motility#GO:0048870;cellular process#GO:0009987;cell migration#GO:0016477;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 Integrin signalling pathway#P00034>Crk#P00933;Angiogenesis#P00005>Crk#P00207 HELRO|EnsemblGenome=HelroG82107|UniProtKB=T1G4M9 T1G4M9 20216027 PTHR47039:SF1 INOSITOL POLYPHOSPHATE 5-PHOSPHATASE E INOSITOL POLYPHOSPHATE 5-PHOSPHATASE E phosphatase#PC00181 HELRO|EnsemblGenome=HelroG62918|UniProtKB=T1FX76 T1FX76 20213424 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG79474|UniProtKB=T1G3P2 T1G3P2 20215690 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG104619|UniProtKB=T1EDM6 T1EDM6 20194678 PTHR22840:SF12 WD REPEAT-CONTAINING PROTEIN 36 WD REPEAT-CONTAINING PROTEIN 36 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981;90S preribosome#GO:0030686;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG191851|UniProtKB=T1FTC7 T1FTC7 20212074 PTHR14516:SF6 1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE FAMILY MEMBER MULTIFUNCTIONAL FUSION PROTEIN dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG65292|UniProtKB=T1FY55 T1FY55 20213753 PTHR14741:SF32 S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED TRIMETHYLGUANOSINE SYNTHASE RNA metabolism protein#PC00031;RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG170551|UniProtKB=T1F366 T1F366 20203265 PTHR15729:SF10 CDC42 GTPASE-ACTIVATING PROTEIN GTPASE-ACTIVATING PROTEIN CDGAPR nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG187365|UniProtKB=T1FP93 T1FP93 20210640 PTHR45624:SF12 MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED MITOCHONDRIAL ORNITHINE TRANSPORTER 1 L-amino acid transmembrane transporter activity#GO:0015179;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 L-amino acid transport#GO:0015807;transmembrane transport#GO:0055085;amino acid transport#GO:0006865;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;nitrogen compound transport#GO:0071705;carboxylic acid transport#GO:0046942;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039;mitochondrial transport#GO:0006839;localization#GO:0051179;organic substance transport#GO:0071702;amino acid transmembrane transport#GO:0003333;establishment of localization#GO:0051234;L-alpha-amino acid transmembrane transport#GO:1902475;organic acid transmembrane transport#GO:1903825;mitochondrial transmembrane transport#GO:1990542 transporter#PC00227 HELRO|EnsemblGenome=HelroG75439|UniProtKB=T1G251 T1G251 20215149 PTHR11920:SF501 GUANYLYL CYCLASE GUANYLATE CYCLASE 32E adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG80374|UniProtKB=T1G400 T1G400 20215798 PTHR45636:SF41 PAIRED BOX PROTEIN PAX-6-RELATED-RELATED PAIRED BOX PROTEIN PAX-6-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG178141|UniProtKB=T1FCT9 T1FCT9 20206638 PTHR12425:SF5 SYNEMBRYN SYNEMBRYN nucleoside-triphosphatase regulator activity#GO:0060589;protein binding#GO:0005515;GTPase regulator activity#GO:0030695;binding#GO:0005488;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG181758|UniProtKB=T1FHA5 T1FHA5 20208204 PTHR24256:SF572 TRYPTASE-RELATED PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185452|UniProtKB=T1FMU3 T1FMU3 20210142 PTHR10855:SF1 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12 cytoplasm#GO:0005737;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;proteasome accessory complex#GO:0022624;proteasome regulatory particle#GO:0005838;catalytic complex#GO:1902494;proteasome regulatory particle, lid subcomplex#GO:0008541;endopeptidase complex#GO:1905369;proteasome complex#GO:0000502;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 protease#PC00190 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489;Cell cycle#P00013>Proteasome#P00480 HELRO|EnsemblGenome=HelroG86826|UniProtKB=T1G6H6 T1G6H6 20216673 PTHR45797:SF3 RAD54-LIKE TRANSCRIPTIONAL REGULATOR ATRX HOMOLOG membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG182970|UniProtKB=T1FJ05 T1FJ05 20208804 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193110|UniProtKB=T1FUM7 T1FUM7 20212523 PTHR11742:SF55 MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 carbohydrate derivative metabolic process#GO:1901135;macromolecule modification#GO:0043412;protein catabolic process#GO:0030163;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;macromolecule catabolic process#GO:0009057;response to endoplasmic reticulum stress#GO:0034976;response to oxygen-containing compound#GO:1901700;macromolecule metabolic process#GO:0043170;carbohydrate derivative catabolic process#GO:1901136;organonitrogen compound metabolic process#GO:1901564;ERAD pathway#GO:0036503;response to organonitrogen compound#GO:0010243;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;cellular response to stress#GO:0033554 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG169168|UniProtKB=T1F1I6 T1F1I6 20202686 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172663|UniProtKB=T1F5R4 T1F5R4 20204163 PTHR24418:SF294 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE BTK29A protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG162835|UniProtKB=T1ET88 T1ET88 20199788 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG109002|UniProtKB=T1EEP8 T1EEP8 20195050 PTHR13005:SF4 CYSTEINE-RICH HYDROPHOBIC DOMAIN PROTEIN BRAIN X-LINKED PROTEIN CYSTEINE-RICH HYDROPHOBIC PROTEIN HELRO|EnsemblGenome=HelroG111410|UniProtKB=T1EFB0 T1EFB0 20195262 PTHR24064:SF577 SOLUTE CARRIER FAMILY 22 MEMBER GH09241P secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG133620|UniProtKB=T1EI17 T1EI17 20196217 PTHR24416:SF564 TYROSINE-PROTEIN KINASE RECEPTOR MACROPHAGE-STIMULATING PROTEIN RECEPTOR signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;nervous system development#GO:0007399;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;system development#GO:0048731;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cell motility#GO:0048870;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;cell migration#GO:0016477;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG81324|UniProtKB=T1G4D0 T1G4D0 20215928 PTHR23506:SF23 GH10249P GH10249P secondary carrier transporter#PC00258;transporter#PC00227 Adrenaline and noradrenaline biosynthesis#P00001>VAT1#P00071;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>VAChT#P01078;5HT3 type receptor mediated signaling pathway#P04375>5HT vesicular transporter#P04424;5HT2 type receptor mediated signaling pathway#P04374>5HT vesicular transporter#P04418;Nicotinic acetylcholine receptor signaling pathway#P00044>VAChT#P01089;5HT4 type receptor mediated signaling pathway#P04376>5HT vesicular transporter#P04432;5HT1 type receptor mediated signaling pathway#P04373>5HT vesicular transporter#P04410 HELRO|EnsemblGenome=HelroG186005|UniProtKB=T1FNJ4 T1FNJ4 20210391 PTHR24012:SF918 RNA BINDING PROTEIN RRM DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159;mRNA binding#GO:0003729;poly(A) binding#GO:0008143;mRNA 3'-UTR binding#GO:0003730 supramolecular complex#GO:0099080;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein complex#GO:1990904;ribonucleoprotein granule#GO:0035770;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;cytoplasmic stress granule#GO:0010494 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG181141|UniProtKB=T1FGN5 T1FGN5 20207984 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG75629|UniProtKB=T1G278 T1G278 20215176 PTHR24416:SF600 TYROSINE-PROTEIN KINASE RECEPTOR PDGF- AND VEGF-RECEPTOR RELATED, ISOFORM J signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG102934|UniProtKB=T1EDD3 T1EDD3 20194585 PTHR23323:SF24 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 organelle localization#GO:0051640;transport#GO:0006810;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;exocytic process#GO:0140029;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;endosome organization#GO:0007032;vacuole organization#GO:0007033;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;organelle organization#GO:0006996;vesicle organization#GO:0016050;export from cell#GO:0140352;organelle fusion#GO:0048284;secretion by cell#GO:0032940 membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle tethering complex#GO:0099023;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG165816|UniProtKB=T1EXB5 T1EXB5 20201215 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG169144|UniProtKB=T1F1G7 T1F1G7 20202667 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG141216|UniProtKB=T1EJ31 T1EJ31 20196581 PTHR24379:SF121 KRAB AND ZINC FINGER DOMAIN-CONTAINING C2H2-TYPE DOMAIN-CONTAINING PROTEIN C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG88699|UniProtKB=T1G755 T1G755 20216902 PTHR12924:SF0 TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG182155|UniProtKB=T1FHU4 T1FHU4 20208393 PTHR13723:SF313 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;cellular component organization#GO:0016043;cellular process#GO:0009987;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG186287|UniProtKB=T1FNX3 T1FNX3 20210520 PTHR46009:SF1 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG localization#GO:0051179;endosomal transport#GO:0016197;cellular localization#GO:0051641;establishment of localization#GO:0051234;vacuolar transport#GO:0007034;transport#GO:0006810;endosome transport via multivesicular body sorting pathway#GO:0032509;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;late endosome to vacuole transport#GO:0045324;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;late endosome#GO:0005770;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG105460|UniProtKB=T1EDV0 T1EDV0 20194752 PTHR11686:SF9 GAMMA GLUTAMYL TRANSPEPTIDASE RE13973P hydrolase activity#GO:0016787;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 sulfur compound metabolic process#GO:0006790;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;peptide catabolic process#GO:0043171;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;cellular process#GO:0009987;glutathione metabolic process#GO:0006749;sulfur compound catabolic process#GO:0044273;nitrogen compound metabolic process#GO:0006807;cellular modified amino acid metabolic process#GO:0006575;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG64347|UniProtKB=T1FXT2 T1FXT2 20213630 PTHR48015:SF33 SERINE/THREONINE-PROTEIN KINASE TAO SERINE_THREONINE-PROTEIN KINASE HIPPO transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of cell communication#GO:0010646;cellular response to stimulus#GO:0051716;regulation of MAPK cascade#GO:0043408;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;regulation of signaling#GO:0023051;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;regulation of intracellular signal transduction#GO:1902531;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG88593|UniProtKB=T1G742 T1G742 20216889 PTHR12980:SF0 UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX, SUBUNIT X CYTOCHROME B-C1 COMPLEX SUBUNIT 9 mitochondrial ATP synthesis coupled electron transport#GO:0042775;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;respiratory electron transport chain#GO:0022904;aerobic electron transport chain#GO:0019646;oxidative phosphorylation#GO:0006119;generation of precursor metabolites and energy#GO:0006091;electron transport chain#GO:0022900;ATP synthesis coupled electron transport#GO:0042773;cellular metabolic process#GO:0044237;mitochondrial electron transport, ubiquinol to cytochrome c#GO:0006122;cellular process#GO:0009987;energy derivation by oxidation of organic compounds#GO:0015980;metabolic process#GO:0008152 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;cytochrome complex#GO:0070069;respiratory chain complex#GO:0098803;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transporter complex#GO:1990351;oxidoreductase complex#GO:1990204;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;respirasome#GO:0070469;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;mitochondrial respirasome#GO:0005746;transmembrane transporter complex#GO:1902495;inner mitochondrial membrane protein complex#GO:0098800;mitochondrial respiratory chain complex III#GO:0005750;membrane-bounded organelle#GO:0043227;mitochondrial protein-containing complex#GO:0098798 reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG90481|UniProtKB=T1G7S0 T1G7S0 20217117 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG181618|UniProtKB=T1FH65 T1FH65 20208164 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG110956|UniProtKB=T1EF66 T1EF66 20195218 PTHR16288:SF0 WD40 REPEAT PROTEIN 4 TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;methyltransferase complex#GO:0034708;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG180686|UniProtKB=T1FG61 T1FG61 20207810 PTHR21681:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical entity#GO:0110165;eukaryotic translation initiation factor 3 complex#GO:0005852;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG176378|UniProtKB=T1FAG5 T1FAG5 20205814 PTHR12242:SF45 OS02G0130600 PROTEIN-RELATED MARVEL DOMAIN-CONTAINING PROTEIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG182354|UniProtKB=T1FI38 T1FI38 20208487 PTHR46543:SF1 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;modification-dependent macromolecule catabolic process#GO:0043632;regulation of biological process#GO:0050789;ncRNA metabolic process#GO:0034660;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;mRNA catabolic process#GO:0006402;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;negative regulation of cellular process#GO:0048523;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;snRNA metabolic process#GO:0016073;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;nuclear-transcribed mRNA catabolic process#GO:0000956;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;rRNA metabolic process#GO:0016072;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;polyadenylation-dependent ncRNA catabolic process#GO:0043634;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG184827|UniProtKB=T1FM21 T1FM21 20209870 PTHR11040:SF211 ZINC/IRON TRANSPORTER ZINC TRANSPORTER ZIP11 inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;transition metal ion transport#GO:0000041;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG90150|UniProtKB=T1G7L7 T1G7L7 20217064 PTHR10680:SF14 PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE oxygenase#PC00177 Vasopressin synthesis#P04395>Amidating Enzyme#P04599 HELRO|EnsemblGenome=HelroG100074|UniProtKB=T1ECY4 T1ECY4 20194436 PTHR24355:SF28 G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE G PROTEIN-COUPLED RECEPTOR KINASE 2 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of cell communication#GO:0010646;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;regulation of signaling#GO:0023051;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>GPRK#P00840 HELRO|EnsemblGenome=HelroG191893|UniProtKB=T1FTE4 T1FTE4 20212091 PTHR21091:SF169 METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED UROPORPHYRINOGEN DECARBOXYLASE methyltransferase#PC00155 Heme biosynthesis#P02746>Uroporphyrinogen decarboxylase#P02975 HELRO|EnsemblGenome=HelroG180244|UniProtKB=T1FFM2 T1FFM2 20207621 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG181665|UniProtKB=T1FH78 T1FH78 20208177 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163281|UniProtKB=T1ETV3 T1ETV3 20200003 PTHR12932:SF9 P25 ALPHA-RELATED TUBULIN POLYMERIZATION-PROMOTING PROTEIN HOMOLOG cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;microtubule cytoskeleton organization#GO:0000226;protein-containing complex assembly#GO:0065003;regulation of cellular component organization#GO:0051128;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule polymerization or depolymerization#GO:0031109;positive regulation of protein polymerization#GO:0032273;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of protein-containing complex assembly#GO:0043254;microtubule polymerization#GO:0046785;microtubule-based process#GO:0007017;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;protein-containing complex organization#GO:0043933;supramolecular fiber organization#GO:0097435;microtubule bundle formation#GO:0001578;biological regulation#GO:0065007;protein polymerization#GO:0051258;positive regulation of cellular component organization#GO:0051130;cytoskeleton organization#GO:0007010;positive regulation of cellular component biogenesis#GO:0044089;regulation of protein polymerization#GO:0032271;positive regulation of biological process#GO:0048518 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG141692|UniProtKB=T1EJ40 T1EJ40 20196590 PTHR24347:SF412 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE H1 HOMOLOG-RELATED non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CaMK#P00847;Ionotropic glutamate receptor pathway#P00037>CaMKII#P01023 HELRO|EnsemblGenome=HelroG167992|UniProtKB=T1F018 T1F018 20202168 PTHR16451:SF7 MITOCHONDRIAL DYNAMICS PROTEINS 49/51 FAMILY MEMBER MAB-21-LIKE HHH_H2TH-LIKE DOMAIN-CONTAINING PROTEIN regulation of biological process#GO:0050789;positive regulation of organelle organization#GO:0010638;regulation of developmental process#GO:0050793;regulation of anatomical structure morphogenesis#GO:0022603;regulation of mitochondrion organization#GO:0010821;regulation of cellular process#GO:0050794;regulation of organelle organization#GO:0033043;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;regulation of cellular component organization#GO:0051128;positive regulation of developmental process#GO:0051094;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 envelope#GO:0031975;bounding membrane of organelle#GO:0098588;mitochondrial membrane#GO:0031966;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867 HELRO|EnsemblGenome=HelroG192080|UniProtKB=T1FTK2 T1FTK2 20212149 PTHR24034:SF205 EGF-LIKE DOMAIN-CONTAINING PROTEIN NIDOGEN extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG159466|UniProtKB=T1EP24 T1EP24 20198324 PTHR21229:SF1 LUNG SEVEN TRANSMEMBRANE RECEPTOR GH17801P localization#GO:0051179;establishment of localization#GO:0051234;transport#GO:0006810 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG190034|UniProtKB=T1FRM0 T1FRM0 20211467 PTHR23107:SF34 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN HTH LA-TYPE RNA-BINDING DOMAIN-CONTAINING PROTEIN transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG64291|UniProtKB=T1FXS4 T1FXS4 20213622 PTHR31746:SF3 TRANSMEMBRANE PROTEIN 229 FAMILY MEMBER TRANSMEMBRANE PROTEIN 229B HELRO|EnsemblGenome=HelroG189100|UniProtKB=T1FQN2 T1FQN2 20211129 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG191226|UniProtKB=T1FSR5 T1FSR5 20211862 PTHR11675:SF68 N-ACETYLGALACTOSAMINYLTRANSFERASE N-ACETYLGALACTOSAMINYLTRANSFERASE 7 transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG175481|UniProtKB=T1F9A9 T1F9A9 20205408 PTHR14592:SF14 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG175939|UniProtKB=T1F9X9 T1F9X9 20205628 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG100648|UniProtKB=T1ED10 T1ED10 20194462 PTHR45623:SF17 CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED ATP-dependent activity, acting on DNA#GO:0008094;nucleic acid binding#GO:0003676;binding#GO:0005488;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887;histone binding#GO:0042393;pyrophosphatase activity#GO:0016462;ATP-dependent activity#GO:0140657;chromatin binding#GO:0003682;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity, acting on DNA#GO:0140097;protein-containing complex binding#GO:0044877 cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;protein-DNA complex organization#GO:0071824;cellular component organization#GO:0016043;cellular process#GO:0009987;chromatin remodeling#GO:0006338;protein-containing complex organization#GO:0043933 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG122255|UniProtKB=T1EGU3 T1EGU3 20195793 PTHR11767:SF102 INWARD RECTIFIER POTASSIUM CHANNEL INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of localization#GO:0032879;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;import across plasma membrane#GO:0098739;regulation of transport#GO:0051049;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;regulation of monoatomic ion transport#GO:0043269;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;potassium ion transport#GO:0006813;potassium ion import across plasma membrane#GO:1990573 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG158491|UniProtKB=T1EMU9 T1EMU9 20197899 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG85855|UniProtKB=T1G635 T1G635 20216532 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164641|UniProtKB=T1EVN8 T1EVN8 20200638 PTHR15151:SF24 PROTEIN EIGER A PROLIFERATION-INDUCING LIGAND-LIKE PROTEIN-RELATED molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;binding#GO:0005488;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;protein binding#GO:0005515;signaling receptor binding#GO:0005102 extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG183486|UniProtKB=T1FJR1 T1FJR1 20209060 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG158879|UniProtKB=T1END0 T1END0 20198080 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178880|UniProtKB=T1FDU7 T1FDU7 20206996 PTHR24416:SF539 TYROSINE-PROTEIN KINASE RECEPTOR RECEPTOR PROTEIN-TYROSINE KINASE signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG90411|UniProtKB=T1G7R1 T1G7R1 20217108 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193188|UniProtKB=T1FUQ3 T1FUQ3 20212549 PTHR10900:SF124 PERIOSTIN-RELATED FI05614P cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;binding#GO:0005488 cellular component organization or biogenesis#GO:0071840;cell adhesion#GO:0007155;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;extracellular space#GO:0005615;extracellular region#GO:0005576 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG124831|UniProtKB=T1EH31 T1EH31 20195881 PTHR10300:SF14 CALCIPRESSIN PROTEIN SARAH phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;calcium-mediated signaling#GO:0019722;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG87723|UniProtKB=T1G6U8 T1G6U8 20216795 PTHR23248:SF63 PHOSPHOLIPID SCRAMBLASE-RELATED PHOSPHOLIPID SCRAMBLASE phospholipid transporter activity#GO:0005548;transporter activity#GO:0005215;lipid transporter activity#GO:0005319 organophosphate ester transport#GO:0015748;macromolecule localization#GO:0033036;membrane organization#GO:0061024;plasma membrane organization#GO:0007009;transport#GO:0006810;plasma membrane phospholipid scrambling#GO:0017121;endomembrane system organization#GO:0010256;cellular component organization#GO:0016043;regulation of membrane lipid distribution#GO:0097035;phospholipid transport#GO:0015914;cellular process#GO:0009987;lipid transport#GO:0006869;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;biological regulation#GO:0065007;lipid translocation#GO:0034204;lipid localization#GO:0010876;phospholipid translocation#GO:0045332 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG75495|UniProtKB=T1G259 T1G259 20215157 PTHR18860:SF159 14-3-3 PROTEIN 14-3-3 PROTEIN ZETA localization#GO:0051179;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular localization#GO:0051641;cellular response to stimulus#GO:0051716;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052;protein localization#GO:0008104 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 Parkinson disease#P00049>14-3-3#P01238;FGF signaling pathway#P00021>14-3-3#P00624;EGF receptor signaling pathway#P00018>14-3-3#P00539;PI3 kinase pathway#P00048>14-3-3#P01206 HELRO|EnsemblGenome=HelroG176178|UniProtKB=T1FA92 T1FA92 20205741 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171587|UniProtKB=T1F4F6 T1F4F6 20203705 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169447|UniProtKB=T1F1Y0 T1F1Y0 20202830 PTHR14716:SF0 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 69 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 69 structural protein#PC00211 HELRO|EnsemblGenome=HelroG160493|UniProtKB=T1EQB3 T1EQB3 20198763 PTHR28608:SF1 INTEGRATOR COMPLEX SUBUNIT 2 INTEGRATOR COMPLEX SUBUNIT 2 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;snRNA metabolic process#GO:0016073;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;snRNA 3'-end processing#GO:0034472;snRNA processing#GO:0016180;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;integrator complex#GO:0032039 HELRO|EnsemblGenome=HelroG193761|UniProtKB=T1FVC0 T1FVC0 20212766 PTHR24248:SF129 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG163206|UniProtKB=T1ETS8 T1ETS8 20199978 PTHR14402:SF10 RECEPTOR TRANSPORTING PROTEIN 3CXXC-TYPE DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;G protein-coupled receptor binding#GO:0001664;binding#GO:0005488;signaling receptor binding#GO:0005102 localization within membrane#GO:0051668;cellular localization#GO:0051641;macromolecule localization#GO:0033036;membrane organization#GO:0061024;protein localization to membrane#GO:0072657;protein targeting#GO:0006605;cellular component organization#GO:0016043;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to membrane#GO:0090150;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein insertion into membrane#GO:0051205 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG177464|UniProtKB=T1FBQ6 T1FBQ6 20206255 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165659|UniProtKB=T1EX51 T1EX51 20201151 PTHR24082:SF283 NUCLEAR HORMONE RECEPTOR NUCLEAR HORMONE RECEPTOR HR96 cis-regulatory region sequence-specific DNA binding#GO:0000987;signaling receptor activity#GO:0038023;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of RNA metabolic process#GO:0051253;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of transcription by RNA polymerase II#GO:0000122;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;cellular developmental process#GO:0048869;negative regulation of biosynthetic process#GO:0009890;regulation of DNA-templated transcription#GO:0006355;negative regulation of metabolic process#GO:0009892;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;negative regulation of nitrogen compound metabolic process#GO:0051172;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG74132|UniProtKB=T1G1M5 T1G1M5 20214973 PTHR20931:SF0 TETRATRICOPEPTIDE REPEAT PROTEIN 30 TETRATRICOPEPTIDE REPEAT PROTEIN 30 protein-containing complex binding#GO:0044877;binding#GO:0005488 cilium organization#GO:0044782;cellular localization#GO:0051641;cell projection organization#GO:0030030;transport#GO:0006810;microtubule-based movement#GO:0007018;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;transport along microtubule#GO:0010970;intraciliary transport#GO:0042073;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;microtubule-based transport#GO:0099111;establishment of localization#GO:0051234;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;protein-containing complex localization#GO:0031503 supramolecular complex#GO:0099080;axoneme#GO:0005930;cytoplasmic microtubule#GO:0005881;cytoplasmic region#GO:0099568;supramolecular polymer#GO:0099081;cellular anatomical entity#GO:0110165;supramolecular fiber#GO:0099512;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;intraciliary transport particle B#GO:0030992;microtubule cytoskeleton#GO:0015630;ciliary plasm#GO:0097014;membrane-bounded organelle#GO:0043227;plasma membrane bounded cell projection cytoplasm#GO:0032838;cell projection#GO:0042995;cytoskeleton#GO:0005856;cilium#GO:0005929;microtubule#GO:0005874;intraciliary transport particle#GO:0030990;axonemal microtubule#GO:0005879 HELRO|EnsemblGenome=HelroG129825|UniProtKB=T1EHS5 T1EHS5 20196125 PTHR19818:SF157 ZINC FINGER PROTEIN ZIC AND GLI C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG73582|UniProtKB=T1G1G1 T1G1G1 20214909 PTHR28052:SF1 UPF0545 PROTEIN C22ORF39 UPF0545 PROTEIN C22ORF39 HELRO|EnsemblGenome=HelroG73503|UniProtKB=T1G1E8 T1G1E8 20214896 PTHR12292:SF2 RWD DOMAIN-CONTAINING PROTEIN RWD DOMAIN-CONTAINING PROTEIN 1 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cytoplasmic translation#GO:0002181;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;translation#GO:0006412;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG153356|UniProtKB=T1EL49 T1EL49 20197299 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164610|UniProtKB=T1EVM8 T1EVM8 20200628 PTHR10782:SF4 ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN TONALLI, ISOFORM E transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;SUMO transferase activity#GO:0019789;SUMO ligase activity#GO:0061665;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;protein sumoylation#GO:0016925;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG90804|UniProtKB=T1G7W6 T1G7W6 20217163 PTHR24054:SF0 CASEIN KINASE II SUBUNIT ALPHA CASEIN KINASE II SUBUNIT ALPHA transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;peptidyl-threonine phosphorylation#GO:0018107;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;regulation of cell cycle#GO:0051726;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;cytosol#GO:0005829;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227 Cadherin signaling pathway#P00012>Casein kinase II#P00462;Wnt signaling pathway#P00057>Casein Kinase 2#P01459;Parkinson disease#P00049>Casein kinase II#P01236 HELRO|EnsemblGenome=HelroG67160|UniProtKB=T1FYX5 T1FYX5 20214023 PTHR45775:SF6 RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C HELRO|EnsemblGenome=HelroG180048|UniProtKB=T1FFE3 T1FFE3 20207542 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG126544|UniProtKB=T1EHA3 T1EHA3 20195953 PTHR10986:SF16 39S RIBOSOMAL PROTEIN L20 LARGE RIBOSOMAL SUBUNIT PROTEIN BL20M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;organellar ribosome#GO:0000313;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG167982|UniProtKB=T1F013 T1F013 20202163 PTHR23319:SF4 GRAM DOMAIN CONTAINING 1B, ISOFORM E GRAM DOMAIN CONTAINING 1B, ISOFORM E sterol transfer activity#GO:0120015;lipid transfer activity#GO:0120013;binding#GO:0005488;organic cyclic compound binding#GO:0097159;sterol transporter activity#GO:0015248;steroid binding#GO:0005496;sterol binding#GO:0032934;lipid binding#GO:0008289;transporter activity#GO:0005215;lipid transporter activity#GO:0005319 localization#GO:0051179;organic hydroxy compound transport#GO:0015850;organic substance transport#GO:0071702;cellular localization#GO:0051641;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;sterol transport#GO:0015918;transport#GO:0006810;intracellular sterol transport#GO:0032366;establishment of localization in cell#GO:0051649;lipid localization#GO:0010876;intracellular transport#GO:0046907;cellular process#GO:0009987;lipid transport#GO:0006869;intracellular lipid transport#GO:0032365 intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle membrane contact site#GO:0044232;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG190825|UniProtKB=T1FSB8 T1FSB8 20211715 PTHR23142:SF2 PRE-MRNA-SPLICING FACTOR 38A-RELATED PRE-MRNA-SPLICING FACTOR 38B ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;precatalytic spliceosome#GO:0071011;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG81107|UniProtKB=T1G494 T1G494 20215892 PTHR23257:SF947 SERINE-THREONINE PROTEIN KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG184928|UniProtKB=T1FM62 T1FM62 20209911 PTHR12223:SF45 VESICULAR MANNOSE-BINDING LECTIN RE50040P carbohydrate binding#GO:0030246;small molecule binding#GO:0036094;binding#GO:0005488;monosaccharide binding#GO:0048029 localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987 bounding membrane of organelle#GO:0098588;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;Golgi membrane#GO:0000139;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG104401|UniProtKB=T1EDL4 T1EDL4 20194666 PTHR13105:SF7 MYELOID LEUKEMIA FACTOR MYELOID LEUKEMIA FACTOR intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG175070|UniProtKB=T1F8T2 T1F8T2 20205231 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158884|UniProtKB=T1END4 T1END4 20198084 PTHR19303:SF71 TRANSPOSON ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG91619|UniProtKB=T1G864 T1G864 20217261 PTHR21427:SF19 UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL lipid binding#GO:0008289;binding#GO:0005488 cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;small molecule biosynthetic process#GO:0044283;ubiquinone biosynthetic process#GO:0006744;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG175652|UniProtKB=T1F9H2 T1F9H2 20205471 PTHR24223:SF456 ATP-BINDING CASSETTE SUB-FAMILY C MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659 transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG162955|UniProtKB=T1ETF1 T1ETF1 20199851 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG75683|UniProtKB=T1G288 T1G288 20215186 PTHR11387:SF2 CYTOCHROME C OXIDASE SUBUNIT 6B CYTOCHROME C OXIDASE SUBUNIT 6B1 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxidase#PC00175;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG133388|UniProtKB=T1EI08 T1EI08 20196208 PTHR11544:SF60 COLD SHOCK DOMAIN CONTAINING PROTEINS LD37574P nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 HELRO|EnsemblGenome=HelroG187038|UniProtKB=T1FP58 T1FP58 20210605 PTHR11915:SF442 SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN ALPHA-ACTININ, SARCOMERIC-RELATED cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;organelle organization#GO:0006996 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;cell cortex#GO:0005938;cell periphery#GO:0071944;cortical actin cytoskeleton#GO:0030864;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Integrin signalling pathway#P00034>alpha actinin#P00928 HELRO|EnsemblGenome=HelroG178936|UniProtKB=T1FDX5 T1FDX5 20207024 PTHR45889:SF8 IG-LIKE DOMAIN-CONTAINING PROTEIN IG-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG106032|UniProtKB=T1EDZ3 T1EDZ3 20194795 PTHR11472:SF41 DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER ATP-DEPENDENT DNA HELICASE DDX11-RELATED ATP-dependent activity, acting on DNA#GO:0008094;catalytic activity, acting on a nucleic acid#GO:0140640;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824 DNA conformation change#GO:0071103;cellular component organization or biogenesis#GO:0071840;sister chromatid cohesion#GO:0007062;organelle organization#GO:0006996;chromosome organization#GO:0051276;DNA duplex unwinding#GO:0032508;cell cycle process#GO:0022402;cell cycle#GO:0007049;cellular component organization#GO:0016043;cellular process#GO:0009987;DNA geometric change#GO:0032392 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA helicase#PC00011;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG106613|UniProtKB=T1EE37 T1EE37 20194839 PTHR17613:SF14 CEREBRAL PROTEIN-11-RELATED DEMENTIN, ISOFORM H cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG110447|UniProtKB=T1EF21 T1EF21 20195173 PTHR48012:SF16 STERILE20-LIKE KINASE, ISOFORM B-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG170345|UniProtKB=T1F2Y3 T1F2Y3 20203182 PTHR19282:SF477 TETRASPANIN TETRASPANIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG74437|UniProtKB=T1G1R1 T1G1R1 20215009 PTHR23137:SF36 VESICLE TRANSPORT PROTEIN-RELATED VESICLE TRANSPORT PROTEIN SFT2C HELRO|EnsemblGenome=HelroG92149|UniProtKB=T1G8C3 T1G8C3 20217320 PTHR19960:SF7 TEKTIN TEKTIN cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cilium or flagellum-dependent cell motility#GO:0001539;cell motility#GO:0048870;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;cilium movement involved in cell motility#GO:0060294;cilium movement#GO:0003341;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cilium-dependent cell motility#GO:0060285;microtubule-based process#GO:0007017;organelle organization#GO:0006996;plasma membrane bounded cell projection assembly#GO:0120031 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG193788|UniProtKB=T1FVC8 T1FVC8 20212774 PTHR14456:SF2 INOSITOL POLYPHOSPHATE KINASE 1 INOSITOL-PENTAKISPHOSPHATE 2-KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 organic hydroxy compound metabolic process#GO:1901615;organophosphate biosynthetic process#GO:0090407;alcohol biosynthetic process#GO:0046165;cellular metabolic process#GO:0044237;alcohol metabolic process#GO:0006066;organic hydroxy compound biosynthetic process#GO:1901617;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;organophosphate metabolic process#GO:0019637;small molecule biosynthetic process#GO:0044283;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transferase#PC00220;kinase#PC00137;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG178784|UniProtKB=T1FDQ6 T1FDQ6 20206955 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG84628|UniProtKB=T1G5L1 T1G5L1 20216358 PTHR11267:SF106 T-BOX PROTEIN-RELATED T-RELATED PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cell fate commitment#GO:0045165;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;cell fate specification#GO:0001708;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 Wnt signaling pathway#P00057>Wnt Target Genes#G01558 HELRO|EnsemblGenome=HelroG144288|UniProtKB=T1EJE1 T1EJE1 20196691 PTHR43215:SF14 RADIAL SPOKE HEAD 1 HOMOLOG RADIAL SPOKE HEAD 1 HOMOLOG HELRO|EnsemblGenome=HelroG159227|UniProtKB=T1ENR7 T1ENR7 20198217 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG183164|UniProtKB=T1FJ88 T1FJ88 20208887 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77575|UniProtKB=T1G300 T1G300 20215448 PTHR15271:SF4 CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;nucleosome organization#GO:0034728;nucleosome assembly#GO:0006334;protein-containing complex organization#GO:0043933;protein-containing complex assembly#GO:0065003;chromatin organization#GO:0006325;cellular component organization#GO:0016043;cellular process#GO:0009987;chromatin remodeling#GO:0006338;protein-DNA complex assembly#GO:0065004 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG185039|UniProtKB=T1FMB5 T1FMB5 20209964 PTHR11352:SF0 PROLIFERATING CELL NUCLEAR ANTIGEN PROLIFERATING CELL NUCLEAR ANTIGEN enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;DNA-templated DNA replication#GO:0006261;DNA replication#GO:0006260;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA strand elongation involved in DNA replication#GO:0006271 DNA polymerase processivity factor#PC00015 DNA replication#P00017>PCNA#P00534 HELRO|EnsemblGenome=HelroG192394|UniProtKB=T1FTW5 T1FTW5 20212262 PTHR10288:SF340 KH DOMAIN CONTAINING RNA BINDING PROTEIN HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG66677|UniProtKB=T1FYN9 T1FYN9 20213937 PTHR11537:SF254 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG164424|UniProtKB=T1EVE5 T1EVE5 20200545 PTHR46948:SF1 RIBONUCLEASE P PROTEIN SUBUNIT P38 RIBONUCLEASE P PROTEIN SUBUNIT P38 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG79679|UniProtKB=T1G3S2 T1G3S2 20215720 PTHR43520:SF8 ATP7, ISOFORM B P-TYPE CU(+) TRANSPORTER inorganic molecular entity transmembrane transporter activity#GO:0015318;small molecule binding#GO:0036094;binding#GO:0005488;transition metal ion binding#GO:0046914;copper ion binding#GO:0005507;metal ion binding#GO:0046872;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;P-type ion transporter activity#GO:0015662;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;cation binding#GO:0043169;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;ion binding#GO:0043167;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075 monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;monoatomic ion homeostasis#GO:0050801 cellular anatomical entity#GO:0110165;membrane#GO:0016020 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG179294|UniProtKB=T1FEH9 T1FEH9 20207228 PTHR20967:SF0 PROHORMONE-4 PROHORMONE-4 HELRO|EnsemblGenome=HelroG157734|UniProtKB=T1EME9 T1EME9 20197749 PTHR11021:SF0 SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F SMALL NUCLEAR RIBONUCLEOPROTEIN F nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG78026|UniProtKB=T1G369 T1G369 20215517 PTHR11259:SF1 RAS-RELATED GTP BINDING RAG/GTR YEAST RAS-RELATED GTP-BINDING PROTEIN GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of catabolic process#GO:0009894;positive regulation of signal transduction#GO:0009967;regulation of signaling#GO:0023051;response to extracellular stimulus#GO:0009991;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;positive regulation of response to stimulus#GO:0048584;cellular response to starvation#GO:0009267;positive regulation of TOR signaling#GO:0032008;regulation of signal transduction#GO:0009966;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;cellular response to extracellular stimulus#GO:0031668;regulation of cell communication#GO:0010646;positive regulation of TORC1 signaling#GO:1904263;cellular response to stimulus#GO:0051716;regulation of TORC1 signaling#GO:1903432;regulation of autophagy#GO:0010506;negative regulation of cellular catabolic process#GO:0031330;negative regulation of metabolic process#GO:0009892;cell communication#GO:0007154;response to nutrient levels#GO:0031667;regulation of cellular catabolic process#GO:0031329;negative regulation of autophagy#GO:0010507;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to stress#GO:0006950;negative regulation of catabolic process#GO:0009895;regulation of cellular process#GO:0050794;cellular response to nutrient levels#GO:0031669;response to starvation#GO:0042594;positive regulation of cell communication#GO:0010647;biological regulation#GO:0065007;cellular response to external stimulus#GO:0071496;cellular response to stress#GO:0033554;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;lysosome#GO:0005764;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;lytic vacuole#GO:0000323;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG181736|UniProtKB=T1FH98 T1FH98 20208197 PTHR24115:SF194 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF6 pyrophosphatase activity#GO:0016462;cytoskeletal protein binding#GO:0008092;microtubule motor activity#GO:0003777;tubulin binding#GO:0015631;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;cytoskeletal motor activity#GO:0003774;microtubule binding#GO:0008017;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;microtubule associated complex#GO:0005875;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG189737|UniProtKB=T1FRB5 T1FRB5 20211362 PTHR24031:SF96 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX56-RELATED intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG192159|UniProtKB=T1FTN0 T1FTN0 20212177 PTHR44027:SF7 DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG chaperone#PC00072 HELRO|EnsemblGenome=HelroG170184|UniProtKB=T1F2R7 T1F2R7 20203116 PTHR19302:SF13 GAMMA TUBULIN COMPLEX PROTEIN GAMMA-TUBULIN COMPLEX COMPONENT 2 cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;meiotic cell cycle#GO:0051321;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule polymerization or depolymerization#GO:0031109;chromosome segregation#GO:0007059;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;reproduction#GO:0000003;microtubule polymerization#GO:0046785;microtubule-based process#GO:0007017;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;supramolecular fiber organization#GO:0097435;sexual reproduction#GO:0019953;protein polymerization#GO:0051258;spindle assembly#GO:0051225;reproductive process#GO:0022414;cell cycle#GO:0007049;cytoskeleton organization#GO:0007010;spindle organization#GO:0007051;non-membrane-bounded organelle assembly#GO:0140694;microtubule nucleation#GO:0007020;cytoplasmic microtubule organization#GO:0031122 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG63114|UniProtKB=T1FXB1 T1FXB1 20213459 PTHR11705:SF91 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B FI01817P-RELATED metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metallocarboxypeptidase activity#GO:0004181;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;carboxypeptidase activity#GO:0004180 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG189088|UniProtKB=T1FQM5 T1FQM5 20211122 PTHR13518:SF1 PUTATIVE TREBLE-CLEF ZINC-FINGER C2ORF42 FAMILY MEMBER C2ORF42 HOMOLOG membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG71494|UniProtKB=T1G0M3 T1G0M3 20214621 PTHR46810:SF1 INACTIVE POLYGLYCYLASE TTLL10 INACTIVE POLYGLYCYLASE TTLL10 ligase activity#GO:0016874;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;primary metabolic process#GO:0044238 HELRO|EnsemblGenome=HelroG193037|UniProtKB=T1FUJ9 T1FUJ9 20212495 PTHR43831:SF1 ISOBUTYRYL-COA DEHYDROGENASE ISOBUTYRYL-COA DEHYDROGENASE, MITOCHONDRIAL dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG182712|UniProtKB=T1FIM6 T1FIM6 20208675 PTHR12837:SF15 POLY ADP-RIBOSE GLYCOHYDROLASE POLY(ADP-RIBOSE) GLYCOHYDROLASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 ribonucleoside triphosphate metabolic process#GO:0009199;cellular aromatic compound metabolic process#GO:0006725;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative metabolic process#GO:1901135;regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA metabolic process#GO:0051052;regulation of DNA repair#GO:0006282;nucleotide-sugar metabolic process#GO:0009225;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;regulation of cellular response to stress#GO:0080135;organic cyclic compound metabolic process#GO:1901360;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule metabolic process#GO:0043170;purine ribonucleoside triphosphate metabolic process#GO:0009205;regulation of response to stress#GO:0080134;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;regulation of response to stimulus#GO:0048583;regulation of primary metabolic process#GO:0080090;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;purine nucleoside triphosphate metabolic process#GO:0009144;nucleotide metabolic process#GO:0009117;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosidase#PC00110;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG188180|UniProtKB=T1FPQ9 T1FPQ9 20210806 PTHR15678:SF6 ANTIGEN MLAA-22-RELATED BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2 HELRO|EnsemblGenome=HelroG76581|UniProtKB=T1G2L6 T1G2L6 20215314 PTHR48034:SF6 TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED TRANSFORMER-2 SEX-DETERMINING PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 positive regulation of gene expression#GO:0010628;positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of mRNA metabolic process#GO:1903313;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of mRNA processing#GO:0050684;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule biosynthetic process#GO:0010556;regulation of mRNA splicing, via spliceosome#GO:0048024;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG191481|UniProtKB=T1FT09 T1FT09 20211956 PTHR16199:SF4 CONDENSIN-2 COMPLEX SUBUNIT G2 CONDENSIN-2 COMPLEX SUBUNIT G2 nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;nuclear division#GO:0000280;cell cycle process#GO:0022402;cellular component organization#GO:0016043;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;chromosome organization#GO:0051276;organelle organization#GO:0006996;mitotic nuclear division#GO:0140014;organelle fission#GO:0048285;cell cycle#GO:0007049;mitotic sister chromatid segregation#GO:0000070 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG195030|UniProtKB=T1FWP0 T1FWP0 20213235 PTHR13020:SF25 TRINUCLEOTIDE REPEAT-CONTAINING GENE 6 PROTEIN GAWKY negative regulation of gene expression#GO:0010629;positive regulation of nitrogen compound metabolic process#GO:0051173;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of catabolic process#GO:0009894;regulation of mRNA catabolic process#GO:0061013;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;positive regulation of cellular catabolic process#GO:0031331;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;regulatory ncRNA-mediated post-transcriptional gene silencing#GO:0035194;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;regulatory ncRNA-mediated gene silencing#GO:0031047;positive regulation of mRNA metabolic process#GO:1903313;negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;regulation of cellular catabolic process#GO:0031329;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;positive regulation of mRNA catabolic process#GO:0061014;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;positive regulation of catabolic process#GO:0009896;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;supramolecular complex#GO:0099080;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;P-body#GO:0000932;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic ribonucleoprotein granule#GO:0036464;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG81386|UniProtKB=T1G4D9 T1G4D9 20215937 PTHR46917:SF1 MORN REPEAT-CONTAINING PROTEIN 2 MORN REPEAT-CONTAINING PROTEIN 2 HELRO|EnsemblGenome=HelroG178493|UniProtKB=T1FD93 T1FD93 20206792 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188646|UniProtKB=T1FQ78 T1FQ78 20210975 PTHR46961:SF13 DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN DYNEIN AXONEMAL HEAVY CHAIN 3 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG192484|UniProtKB=T1FU05 T1FU05 20212301 PTHR13271:SF47 UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE ACTIN-HISTIDINE N-METHYLTRANSFERASE N-methyltransferase activity#GO:0008170;transferase activity#GO:0016740;catalytic activity#GO:0003824;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;protein-lysine N-methyltransferase activity#GO:0016279;catalytic activity, acting on a protein#GO:0140096;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;lysine N-methyltransferase activity#GO:0016278;protein methyltransferase activity#GO:0008276 macromolecule methylation#GO:0043414;methylation#GO:0032259;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 transferase#PC00220;methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG166079|UniProtKB=T1EXQ1 T1EXQ1 20201351 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER FI01427P membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG69628|UniProtKB=T1FZX5 T1FZX5 20214373 PTHR24247:SF241 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE RECEPTOR 2A-RELATED signaling receptor activity#GO:0038023;G protein-coupled amine receptor activity#GO:0008227;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission#GO:0007268;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;synaptic signaling#GO:0099536;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;cell-cell signaling#GO:0007267 somatodendritic compartment#GO:0036477;neuron projection#GO:0043005;dendrite#GO:0030425;cell periphery#GO:0071944;dendritic tree#GO:0097447;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 5HT2 type receptor mediated signaling pathway#P04374>5HT2 Receptor#P04414;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720 HELRO|EnsemblGenome=HelroG182662|UniProtKB=T1FIJ9 T1FIJ9 20208648 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG167034|UniProtKB=T1EYX6 T1EYX6 20201776 PTHR24161:SF124 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED TRANSIENT RECEPTOR POTENTIAL CHANNEL PYREXIA protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG159372|UniProtKB=T1ENY7 T1ENY7 20198287 PTHR24241:SF193 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;binding#GO:0005488;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888;amide binding#GO:0033218 response to organic substance#GO:0010033;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;response to hormone#GO:0009725;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG125603|UniProtKB=T1EH69 T1EH69 20195919 PTHR23055:SF69 CALCIUM BINDING PROTEINS NEURONAL CALCIUM SENSOR 2 cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG186013|UniProtKB=T1FNJ7 T1FNJ7 20210394 PTHR13608:SF3 ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3 ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG122624|UniProtKB=T1EGV3 T1EGV3 20195803 PTHR11537:SF113 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;delayed rectifier potassium channel activity#GO:0005251;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG156394|UniProtKB=T1ELV4 T1ELV4 20197554 PTHR45668:SF5 SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 5 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG176501|UniProtKB=T1FAL2 T1FAL2 20205861 PTHR12264:SF21 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12 protein binding#GO:0005515;nucleic acid binding#GO:0003676;transcription factor binding#GO:0008134;binding#GO:0005488;organic cyclic compound binding#GO:0097159;TBP-class protein binding#GO:0017025;DNA binding#GO:0003677 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;RNA metabolic process#GO:0016070;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;RNA polymerase II preinitiation complex assembly#GO:0051123;transcription initiation at RNA polymerase II promoter#GO:0006367;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;DNA-directed RNA polymerase complex#GO:0000428;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nucleoplasm#GO:0005654;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;transcription factor TFIID complex#GO:0005669;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;transcription regulator complex#GO:0005667;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 general transcription factor#PC00259 General transcription regulation#P00023>TBP-associated factors#P00658;Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385 HELRO|EnsemblGenome=HelroG190783|UniProtKB=T1FSA5 T1FSA5 20211702 PTHR10663:SF372 GUANYL-NUCLEOTIDE EXCHANGE FACTOR F-BOX ONLY PROTEIN 8 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG167983|UniProtKB=T1F014 T1F014 20202164 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG110149|UniProtKB=T1EEZ9 T1EEZ9 20195151 PTHR11927:SF9 GALACTOSIDE 2-L-FUCOSYLTRANSFERASE L-FUCOSYLTRANSFERASE transferase activity#GO:0016740;fucosyltransferase activity#GO:0008417;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein glycosylation#GO:0006486;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycosylation#GO:0070085;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG195069|UniProtKB=T1FWQ2 T1FWQ2 20213247 PTHR11309:SF148 FRIZZLED SECRETED FRIZZLED-RELATED PROTEIN 1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;protein binding#GO:0005515;Wnt-protein binding#GO:0017147;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;non-canonical Wnt signaling pathway#GO:0035567;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;cell-cell signaling by wnt#GO:0198738;canonical Wnt signaling pathway#GO:0060070;cell-cell signaling#GO:0007267;signaling#GO:0023052;Wnt signaling pathway#GO:0016055 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;extracellular space#GO:0005615;membrane#GO:0016020;extracellular region#GO:0005576;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG104983|UniProtKB=T1EDP5 T1EDP5 20194697 PTHR11780:SF10 NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1 NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG172166|UniProtKB=T1F537 T1F537 20203936 PTHR33332:SF48 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG116543|UniProtKB=T1EGF9 T1EGF9 20195661 PTHR46189:SF1 LD41958P LD41958P cytoplasm#GO:0005737;endosome#GO:0005768;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG145228|UniProtKB=T1EJJ4 T1EJJ4 20196744 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG162789|UniProtKB=T1ET56 T1ET56 20199756 PTHR10155:SF16 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT SUPPRESSOR OF CYTOKINE SIGNALING 2 enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;phosphatidylinositol 3-kinase complex#GO:0005942;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;membrane#GO:0016020;transferase complex, transferring phosphorus-containing groups#GO:0061695;extrinsic component of membrane#GO:0019898 kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG182161|UniProtKB=T1FHU7 T1FHU7 20208396 PTHR15600:SF42 SACSIN SACSIN heat shock protein binding#GO:0031072;protein binding#GO:0005515;protein-folding chaperone binding#GO:0051087;binding#GO:0005488;Hsp70 protein binding#GO:0030544 HELRO|EnsemblGenome=HelroG177383|UniProtKB=T1FBL4 T1FBL4 20206213 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG181061|UniProtKB=T1FGK5 T1FGK5 20207954 PTHR24068:SF126 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 S ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E2#P01491 HELRO|EnsemblGenome=HelroG71629|UniProtKB=T1G0P4 T1G0P4 20214642 PTHR18945:SF879 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission#GO:0007268;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 cell junction#GO:0030054;synapse#GO:0045202;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;neuron projection#GO:0043005 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG187554|UniProtKB=T1FPA7 T1FPA7 20210654 PTHR12746:SF2 NONSENSE-MEDIATED MRNA DECAY PROTEIN 3 60S RIBOSOMAL EXPORT PROTEIN NMD3 ribonucleoprotein complex binding#GO:0043021;ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877;binding#GO:0005488 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG87686|UniProtKB=T1G6U2 T1G6U2 20216789 PTHR24349:SF527 SERINE/THREONINE-PROTEIN KINASE LD17393P transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein serine/threonine kinase activity#GO:0004674;protein binding#GO:0005515;calmodulin binding#GO:0005516;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG67240|UniProtKB=T1FYY7 T1FYY7 20214035 PTHR45673:SF1 SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;protein binding#GO:0005515;calmodulin binding#GO:0005516;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;calcium-mediated signaling#GO:0019722;regulation of cellular process#GO:0050794;calcineurin-mediated signaling#GO:0097720;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052 protein serine/threonine phosphatase complex#GO:0008287;cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 B cell activation#P00010>Calcineurin#P00386;Wnt signaling pathway#P00057>Calcineurin#P01446 HELRO|EnsemblGenome=HelroG64112|UniProtKB=T1FXP5 T1FXP5 20213593 PTHR10217:SF548 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL GH12235P monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG165267|UniProtKB=T1EWI8 T1EWI8 20200938 PTHR40240:SF1 PLEXUS, ISOFORM A PLEXUS, ISOFORM A HELRO|EnsemblGenome=HelroG81462|UniProtKB=T1G4E5 T1G4E5 20215943 PTHR10698:SF0 V-TYPE PROTON ATPASE SUBUNIT H V-TYPE PROTON ATPASE SUBUNIT H ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG195122|UniProtKB=T1FWS0 T1FWS0 20213265 PTHR11467:SF36 HISTONE H1 HISTONE 24-RELATED nucleosome binding#GO:0031491;nucleic acid binding#GO:0003676;chromatin DNA binding#GO:0031490;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;protein-containing complex binding#GO:0044877 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA metabolic process#GO:0051052;chromosome condensation#GO:0030261;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;cellular process#GO:0009987;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;regulation of macromolecule metabolic process#GO:0060255;organelle organization#GO:0006996;chromosome organization#GO:0051276;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA recombination#GO:0045910;negative regulation of DNA metabolic process#GO:0051053;regulation of DNA recombination#GO:0000018;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG185563|UniProtKB=T1FMZ5 T1FMZ5 20210194 PTHR46555:SF1 UBIQUITIN-LIKE PROTEIN 4A UBIQUITIN-LIKE PROTEIN 4A HELRO|EnsemblGenome=HelroG164091|UniProtKB=T1EUX0 T1EUX0 20200370 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189986|UniProtKB=T1FRK2 T1FRK2 20211449 PTHR23291:SF127 BAX INHIBITOR-RELATED PROTEIN LIFEGUARD 1-LIKE regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of apoptotic process#GO:0042981;negative regulation of apoptotic signaling pathway#GO:2001234;negative regulation of response to stimulus#GO:0048585;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of apoptotic signaling pathway#GO:2001233;negative regulation of apoptotic process#GO:0043066;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;negative regulation of programmed cell death#GO:0043069;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of cellular process#GO:0048523;negative regulation of cell communication#GO:0010648;regulation of programmed cell death#GO:0043067 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG71625|UniProtKB=T1G0P2 T1G0P2 20214640 PTHR46229:SF2 BOLA TRANSCRIPTION REGULATOR BOLA-LIKE PROTEIN 1 HELRO|EnsemblGenome=HelroG167810|UniProtKB=T1EZU1 T1EZU1 20202091 PTHR16207:SF11 SET DOMAIN-CONTAINING PROTEIN SET DOMAIN-CONTAINING PROTEIN membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG178002|UniProtKB=T1FCL2 T1FCL2 20206561 PTHR11875:SF7 TESTIS-SPECIFIC Y-ENCODED PROTEIN AT14585P-RELATED protein binding#GO:0005515;protein-containing complex binding#GO:0044877;histone binding#GO:0042393;binding#GO:0005488;chromatin binding#GO:0003682 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;nucleosome organization#GO:0034728;nucleosome assembly#GO:0006334;protein-containing complex organization#GO:0043933;protein-containing complex assembly#GO:0065003;chromatin organization#GO:0006325;cellular component organization#GO:0016043;protein-DNA complex assembly#GO:0065004;chromatin remodeling#GO:0006338;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG95018|UniProtKB=T1G942 T1G942 20217589 PTHR11893:SF36 INNEXIN INNEXIN-5 cell junction protein#PC00070;gap junction#PC00105 HELRO|EnsemblGenome=HelroG176275|UniProtKB=T1FAC8 T1FAC8 20205777 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG80592|UniProtKB=T1G424 T1G424 20215822 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG171341|UniProtKB=T1F452 T1F452 20203601 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG95099|UniProtKB=T1G945 T1G945 20217592 PTHR16007:SF15 EPIDIDYMAL MEMBRANE PROTEIN E9-RELATED TRANSMEMBRANE PROTEIN 45B HELRO|EnsemblGenome=HelroG181677|UniProtKB=T1FH81 T1FH81 20208180 PTHR21258:SF62 DOCKING PROTEIN RELATED INSULIN RECEPTOR SUBSTRATE 1 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194487|UniProtKB=T1FW42 T1FW42 20213038 PTHR38537:SF16 JITTERBUG, ISOFORM N CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG83187|UniProtKB=T1G515 T1G515 20216163 PTHR10472:SF5 D-TYROSYL-TRNA TYR DEACYLASE D-AMINOACYL-TRNA DEACYLASE 1 catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787;catalytic activity, acting on RNA#GO:0140098;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 esterase#PC00097;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG194048|UniProtKB=T1FVM1 T1FVM1 20212867 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG72480|UniProtKB=T1G106 T1G106 20214754 PTHR42884:SF23 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED FURIN-LIKE PROTEASE 2 hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 bounding membrane of organelle#GO:0098588;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791;Golgi membrane#GO:0000139 serine protease#PC00203;protein modifying enzyme#PC00260 Endothelin signaling pathway#P00019>furin#P00575;Alzheimer disease-presenilin pathway#P00004>Furin#P00157;Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105 HELRO|EnsemblGenome=HelroG164701|UniProtKB=T1EVR0 T1EVR0 20200660 PTHR24243:SF230 G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG173109|UniProtKB=T1F6D3 T1F6D3 20204382 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174733|UniProtKB=T1F8F1 T1F8F1 20205100 PTHR19378:SF0 GOLGIN- RELATED HAUS AUGMIN-LIKE COMPLEX SUBUNIT 3 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule organizing center organization#GO:0031023;chromosome segregation#GO:0007059;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;spindle assembly#GO:0051225;cytoskeleton organization#GO:0007010;cell cycle#GO:0007049;spindle organization#GO:0007051;non-membrane-bounded organelle assembly#GO:0140694 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;mitotic spindle#GO:0072686;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;spindle#GO:0005819;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG109564|UniProtKB=T1EEU9 T1EEU9 20195101 PTHR10335:SF17 RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN FIBRILLARIN N-methyltransferase activity#GO:0008170;histone modifying activity#GO:0140993;nucleic acid binding#GO:0003676;binding#GO:0005488;catalytic activity#GO:0003824;histone methyltransferase activity#GO:0042054;catalytic activity, acting on a nucleic acid#GO:0140640;methyltransferase activity#GO:0008168;protein methyltransferase activity#GO:0008276;catalytic activity, acting on RNA#GO:0140098;RNA binding#GO:0003723;transferase activity#GO:0016740;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a rRNA#GO:0140102;transferase activity, transferring one-carbon groups#GO:0016741;rRNA methyltransferase activity#GO:0008649;catalytic activity, acting on a protein#GO:0140096;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;RNA methyltransferase activity#GO:0008173 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA modification#GO:0009451;rRNA modification#GO:0000154;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;ribosome biogenesis#GO:0042254;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;rRNA methylation#GO:0031167;nucleic acid metabolic process#GO:0090304;methylation#GO:0032259;macromolecule methylation#GO:0043414;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;RNA methylation#GO:0001510 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG160940|UniProtKB=T1EQV9 T1EQV9 20198959 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG170711|UniProtKB=T1F3C3 T1F3C3 20203322 PTHR47023:SF1 SEX PEPTIDE RECEPTOR SEX PEPTIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG76189|UniProtKB=T1G2G5 T1G2G5 20215263 PTHR18945:SF865 NEUROTRANSMITTER GATED ION CHANNEL NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA7, ISOFORM E ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG167006|UniProtKB=T1EYW0 T1EYW0 20201760 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG187371|UniProtKB=T1FP95 T1FP95 20210642 PTHR11468:SF13 GLYCOGEN PHOSPHORYLASE GLYCOGEN PHOSPHORYLASE transferase activity#GO:0016740;small molecule binding#GO:0036094;glycosyltransferase activity#GO:0016757;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168;hexosyltransferase activity#GO:0016758 glucan metabolic process#GO:0044042;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;glycogen metabolic process#GO:0005977;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;cellular process#GO:0009987;energy derivation by oxidation of organic compounds#GO:0015980;primary metabolic process#GO:0044238;polysaccharide metabolic process#GO:0005976;carbohydrate catabolic process#GO:0016052;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;energy reserve metabolic process#GO:0006112;carbohydrate metabolic process#GO:0005975;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG178730|UniProtKB=T1FDN0 T1FDN0 20206929 PTHR18849:SF8 LEUCINE RICH REPEAT PROTEIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN 61 cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;outer dynein arm assembly#GO:0036158;cell projection organization#GO:0030030;protein-containing complex assembly#GO:0065003;microtubule cytoskeleton organization#GO:0000226;cellular component organization#GO:0016043;axoneme assembly#GO:0035082;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection assembly#GO:0120031 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG163793|UniProtKB=T1EUH3 T1EUH3 20200223 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG69578|UniProtKB=T1FZW7 T1FZW7 20214365 PTHR19848:SF0 WD40 REPEAT PROTEIN NOTCHLESS PROTEIN HOMOLOG 1 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;organelle assembly#GO:0070925;protein-RNA complex assembly#GO:0022618;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;ribosomal large subunit assembly#GO:0000027;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;protein-RNA complex organization#GO:0071826;non-membrane-bounded organelle assembly#GO:0140694 membrane-enclosed lumen#GO:0031974;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG87165|UniProtKB=T1G6M6 T1G6M6 20216723 PTHR48112:SF22 HIGH MOBILITY GROUP PROTEIN DSP1 MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG170946|UniProtKB=T1F3M1 T1F3M1 20203420 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG160453|UniProtKB=T1EQ94 T1EQ94 20198744 PTHR45689:SF5 I[[H]] CHANNEL, ISOFORM E I[[H]] CHANNEL, ISOFORM E monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;sodium ion transport#GO:0006814;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;regulation of membrane depolarization#GO:0003254;sodium ion transmembrane transport#GO:0035725;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG74885|UniProtKB=T1G1X1 T1G1X1 20215069 PTHR42879:SF2 3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG176946|UniProtKB=T1FB23 T1FB23 20206022 PTHR45929:SF3 JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG178481|UniProtKB=T1FD87 T1FD87 20206786 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194392|UniProtKB=T1FW04 T1FW04 20213000 PTHR45766:SF6 DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A-LIKE PROTEIN 1 DNA metabolism protein#PC00009 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG186563|UniProtKB=T1FP12 T1FP12 20210559 PTHR31017:SF1 LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG191669|UniProtKB=T1FT72 T1FT72 20212019 PTHR13293:SF6 AKIRIN-RELATED AKIRIN-RELATED molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG188701|UniProtKB=T1FQ99 T1FQ99 20210996 PTHR15660:SF1 BRISC AND BRCA1-A COMPLEX MEMBER 1 BRISC AND BRCA1-A COMPLEX MEMBER 1 HELRO|EnsemblGenome=HelroG111094|UniProtKB=T1EF80 T1EF80 20195232 PTHR43856:SF1 CARDIOLIPIN HYDROLASE MITOCHONDRIAL CARDIOLIPIN HYDROLASE catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521 phospholipase#PC00186 HELRO|EnsemblGenome=HelroG171015|UniProtKB=T1F3P7 T1F3P7 20203446 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED BRCT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG102694|UniProtKB=T1EDB0 T1EDB0 20194562 PTHR24416:SF550 TYROSINE-PROTEIN KINASE RECEPTOR FIBROBLAST GROWTH FACTOR RECEPTOR HOMOLOG 1-RELATED signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG174699|UniProtKB=T1F8D8 T1F8D8 20205087 PTHR46480:SF1 F20B24.22 VOLTAGE-GATED HYDROGEN CHANNEL 1 monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;voltage-gated channel activity#GO:0022832;proton channel activity#GO:0015252;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;proton transmembrane transport#GO:1902600;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG176802|UniProtKB=T1FAX4 T1FAX4 20205973 PTHR46763:SF1 DYNEIN REGULATORY COMPLEX PROTEIN 8 DYNEIN REGULATORY COMPLEX PROTEIN 8 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG108015|UniProtKB=T1EEE7 T1EEE7 20194949 PTHR11675:SF43 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 1 transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG126215|UniProtKB=T1EH88 T1EH88 20195938 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED single-stranded RNA binding#GO:0003727;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;poly(A) binding#GO:0008143;binding#GO:0005488;organic cyclic compound binding#GO:0097159 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG184990|UniProtKB=T1FM86 T1FM86 20209935 PTHR10383:SF9 SERINE INCORPORATOR SERINE INCORPORATOR, ISOFORM F cellular anatomical entity#GO:0110165;membrane#GO:0016020 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG176662|UniProtKB=T1FAS1 T1FAS1 20205920 PTHR47202:SF2 HISTIDINE-RICH GLYCOPROTEIN G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG195136|UniProtKB=T1FWS7 T1FWS7 20213272 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG109323|UniProtKB=T1EES4 T1EES4 20195076 PTHR24031:SF292 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX54 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG164168|UniProtKB=T1EV12 T1EV12 20200412 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED BRCT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG107963|UniProtKB=T1EEE4 T1EEE4 20194946 PTHR45759:SF1 NUCLEOLAR GTP-BINDING PROTEIN 1 GTP-BINDING PROTEIN 4 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111 cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;ribosome biogenesis#GO:0042254;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;ribonucleoprotein complex biogenesis#GO:0022613 HELRO|EnsemblGenome=HelroG185636|UniProtKB=T1FN26 T1FN26 20210225 PTHR23073:SF24 26S PROTEASOME REGULATORY SUBUNIT 26S PROTEASOME REGULATORY SUBUNIT 4 ATP-dependent activity#GO:0140657 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 peptidase complex#GO:1905368;protein-containing complex#GO:0032991;proteasome accessory complex#GO:0022624;proteasome regulatory particle#GO:0005838;catalytic complex#GO:1902494;proteasome complex#GO:0000502;endopeptidase complex#GO:1905369;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 protease#PC00190;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG194191|UniProtKB=T1FVS3 T1FVS3 20212919 PTHR11214:SF314 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE HEXOSYLTRANSFERASE transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG188458|UniProtKB=T1FQ04 T1FQ04 20210901 PTHR24193:SF121 ANKYRIN REPEAT PROTEIN ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D HELRO|EnsemblGenome=HelroG162310|UniProtKB=T1ESH9 T1ESH9 20199529 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG63155|UniProtKB=T1FXB7 T1FXB7 20213465 PTHR20856:SF5 DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2 DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA2 catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;RNA polymerase activity#GO:0097747;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;RNA polymerase I activity#GO:0001054 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;RNA polymerase I complex#GO:0005736;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 General transcription by RNA polymerase I#P00022>RNA Polymerase I Complex#P00652 HELRO|EnsemblGenome=HelroG184464|UniProtKB=T1FL92 T1FL92 20209591 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG89856|UniProtKB=T1G7I4 T1G7I4 20217031 PTHR10414:SF37 ETHANOLAMINEPHOSPHOTRANSFERASE BB IN A BOXCAR, ISOFORM C transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG186674|UniProtKB=T1FP23 T1FP23 20210570 PTHR14381:SF1 DACTYLIN F-BOX_WD REPEAT-CONTAINING PROTEIN 4 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234 HELRO|EnsemblGenome=HelroG182715|UniProtKB=T1FIM8 T1FIM8 20208677 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG187748|UniProtKB=T1FPC5 T1FPC5 20210672 PTHR24056:SF233 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 9 cyclin-dependent protein kinase activity#GO:0097472;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG124058|UniProtKB=T1EH00 T1EH00 20195850 PTHR10127:SF780 DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING METALLOENDOPEPTIDASE hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG169994|UniProtKB=T1F2I2 T1F2I2 20203032 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED BRCT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG102182|UniProtKB=T1ED86 T1ED86 20194538 PTHR24303:SF31 HEME-BINDING MONOOXYGENASE FAMILY CYTOCHROME P450 307A1-RELATED oxygenase#PC00177 HELRO|EnsemblGenome=HelroG191346|UniProtKB=T1FSW9 T1FSW9 20211916 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG79631|UniProtKB=T1G3R6 T1G3R6 20215714 PTHR10778:SF8 SOLUTE CARRIER FAMILY 35 MEMBER B ADENOSINE 3'-PHOSPHO 5'-PHOSPHOSULFATE TRANSPORTER 2 carbohydrate derivative transmembrane transporter activity#GO:1901505;purine nucleotide transmembrane transporter activity#GO:0015216;nucleobase-containing compound transmembrane transporter activity#GO:0015932;transmembrane transporter activity#GO:0022857;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215 localization#GO:0051179;organic substance transport#GO:0071702;organophosphate ester transport#GO:0015748;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;organic anion transport#GO:0015711;nucleobase-containing compound transport#GO:0015931;transport#GO:0006810;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264 bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;Golgi membrane#GO:0000139;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG63913|UniProtKB=T1FXM4 T1FXM4 20213572 PTHR12027:SF91 WNT RELATED PROTO-ONCOGENE WNT-1 molecular function activator activity#GO:0140677;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;protein binding#GO:0005515;cytokine activity#GO:0005125;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;neurogenesis#GO:0022008;developmental process#GO:0032502;multicellular organism development#GO:0007275;cell communication#GO:0007154;cell fate commitment#GO:0045165;cell-cell signaling by wnt#GO:0198738;nervous system development#GO:0007399;cellular process#GO:0009987;regulation of biological process#GO:0050789;system development#GO:0048731;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;cell-cell signaling#GO:0007267;signaling#GO:0023052;canonical Wnt signaling pathway#GO:0060070;Wnt signaling pathway#GO:0016055 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Angiogenesis#P00005>Wnt#P00206;Cadherin signaling pathway#P00012>Wnt#P00474 HELRO|EnsemblGenome=HelroG190821|UniProtKB=T1FSB6 T1FSB6 20211713 PTHR13817:SF166 TITIN NEURONAL IGCAM-RELATED structural protein#PC00211 HELRO|EnsemblGenome=HelroG161143|UniProtKB=T1ER51 T1ER51 20199051 PTHR46439:SF3 CYSTEINE-RICH MOTOR NEURON 1 PROTEIN RE54525P HELRO|EnsemblGenome=HelroG142989|UniProtKB=T1EJ84 T1EJ84 20196634 PTHR12290:SF2 CORNICHON-RELATED PHOSPHOPANTOTHENATE--CYSTEINE LIGASE membrane traffic protein#PC00150 Coenzyme A biosynthesis#P02736>Pantothenate cysteine ligase#P02882 HELRO|EnsemblGenome=HelroG183077|UniProtKB=T1FJ49 T1FJ49 20208848 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG168837|UniProtKB=T1F110 T1F110 20202510 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG166964|UniProtKB=T1EYT6 T1EYT6 20201736 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182723|UniProtKB=T1FIN3 T1FIN3 20208682 PTHR46464:SF2 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN ANKYRIN AND ARMADILLO REPEAT-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176391|UniProtKB=T1FAH0 T1FAH0 20205819 PTHR46186:SF2 CYSTATIN CYSTATIN peptidase inhibitor activity#GO:0030414;molecular function regulator activity#GO:0098772;cysteine-type endopeptidase inhibitor activity#GO:0004869;peptidase regulator activity#GO:0061134;enzyme inhibitor activity#GO:0004857;endopeptidase regulator activity#GO:0061135;endopeptidase inhibitor activity#GO:0004866;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 regulation of proteolysis#GO:0030162;negative regulation of hydrolase activity#GO:0051346;negative regulation of biological process#GO:0048519;regulation of protein metabolic process#GO:0051246;regulation of cysteine-type endopeptidase activity#GO:2000116;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of cysteine-type endopeptidase activity#GO:2000117;negative regulation of peptidase activity#GO:0010466;negative regulation of endopeptidase activity#GO:0010951;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of proteolysis#GO:0045861;regulation of catalytic activity#GO:0050790;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of molecular function#GO:0065009;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336;regulation of endopeptidase activity#GO:0052548;regulation of peptidase activity#GO:0052547;negative regulation of catalytic activity#GO:0043086;regulation of metabolic process#GO:0019222;negative regulation of molecular function#GO:0044092 cytoplasm#GO:0005737;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG183623|UniProtKB=T1FJY3 T1FJY3 20209132 PTHR45784:SF5 C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED HELRO|EnsemblGenome=HelroG190923|UniProtKB=T1FSF2 T1FSF2 20211749 PTHR24006:SF888 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30 cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG189402|UniProtKB=T1FR11 T1FR11 20211258 PTHR11388:SF100 ORGANIC ANION TRANSPORTER SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 4A1 transporter#PC00227 HELRO|EnsemblGenome=HelroG159566|UniProtKB=T1EP63 T1EP63 20198363 PTHR11753:SF6 ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY AP-2 COMPLEX SUBUNIT SIGMA localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;cellular process#GO:0009987;transport#GO:0006810 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG185899|UniProtKB=T1FNE9 T1FNE9 20210346 PTHR24250:SF27 CHYMOTRYPSIN-RELATED ELASTASE 2 LIKE hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG177914|UniProtKB=T1FCG5 T1FCG5 20206514 PTHR46480:SF1 F20B24.22 VOLTAGE-GATED HYDROGEN CHANNEL 1 monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;voltage-gated channel activity#GO:0022832;proton channel activity#GO:0015252;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;proton transmembrane transport#GO:1902600;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG185776|UniProtKB=T1FNA0 T1FNA0 PTHR45721:SF12 LAMIN DM0-RELATED INTERMEDIATE FILAMENT PROTEIN IFA-1 structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;nuclear migration#GO:0007097;cellular localization#GO:0051641;negative regulation of biological process#GO:0048519;protein-DNA complex organization#GO:0071824;organelle localization#GO:0051640;macromolecule localization#GO:0033036;membrane organization#GO:0061024;transport#GO:0006810;protein localization to nucleus#GO:0034504;nucleus organization#GO:0006997;endomembrane system organization#GO:0010256;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;protein localization to organelle#GO:0033365;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;establishment of organelle localization#GO:0051656;negative regulation of cellular process#GO:0048523;localization within membrane#GO:0051668;negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;cellular process#GO:0009987;negative regulation of gene expression, epigenetic#GO:0045814;epigenetic regulation of gene expression#GO:0040029;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular macromolecule localization#GO:0070727;heterochromatin organization#GO:0070828;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;chromatin organization#GO:0006325;intracellular transport#GO:0046907;nuclear envelope organization#GO:0006998;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323;protein-containing complex localization#GO:0031503 membrane-enclosed lumen#GO:0031974;envelope#GO:0031975;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;nuclear periphery#GO:0034399;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981 HELRO|EnsemblGenome=HelroG169015|UniProtKB=T1F195 T1F195 20202595 PTHR24056:SF546 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 12 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of transcription elongation by RNA polymerase II#GO:0034243;positive regulation of transcription elongation by RNA polymerase II#GO:0032968;positive regulation of RNA biosynthetic process#GO:1902680;macromolecule modification#GO:0043412;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;protein modification process#GO:0036211;positive regulation of DNA-templated transcription, elongation#GO:0032786;regulation of RNA biosynthetic process#GO:2001141;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;phosphorylation#GO:0016310;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;protein metabolic process#GO:0019538;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;regulation of DNA-templated transcription elongation#GO:0032784;regulation of DNA-templated transcription#GO:0006355;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG68300|UniProtKB=T1FZC8 T1FZC8 20214176 PTHR11886:SF35 DYNEIN LIGHT CHAIN DYNEIN LIGHT CHAIN protein binding#GO:0005515;binding#GO:0005488 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;microtubule cytoskeleton#GO:0015630;dynein complex#GO:0030286;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic dynein complex#GO:0005868;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Dynein complex#P00774 HELRO|EnsemblGenome=HelroG76253|UniProtKB=T1G2H4 T1G2H4 20215272 PTHR12649:SF29 PEPTIDYL-TRNA HYDROLASE 2 AMINOACYL-TRNA HYDROLASE catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787;catalytic activity, acting on RNA#GO:0140098;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG72901|UniProtKB=T1G170 T1G170 20214818 PTHR14927:SF0 NUCLEOLAR PROTEIN 10 NUCLEOLAR PROTEIN 10 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981;90S preribosome#GO:0030686 HELRO|EnsemblGenome=HelroG85890|UniProtKB=T1G639 T1G639 20216536 PTHR11761:SF8 50S/60S RIBOSOMAL PROTEIN L14/L23 LARGE RIBOSOMAL SUBUNIT PROTEIN UL14 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159;rRNA binding#GO:0019843 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG164009|UniProtKB=T1EUR5 T1EUR5 20200315 PTHR43092:SF4 L-CYSTEINE DESULFHYDRASE AMINOTRANSFERASE CLASS V DOMAIN-CONTAINING PROTEIN lyase#PC00144 HELRO|EnsemblGenome=HelroG67681|UniProtKB=T1FZ37 T1FZ37 20214085 PTHR14942:SF0 U11/U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 25 KDA PROTEIN U11_U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 25 KDA PROTEIN HELRO|EnsemblGenome=HelroG81133|UniProtKB=T1G4A0 T1G4A0 20215898 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG190872|UniProtKB=T1FSD5 T1FSD5 20211732 PTHR14002:SF45 ENDOGLIN/TGF-BETA RECEPTOR TYPE III ZP DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG66736|UniProtKB=T1FYQ0 T1FYQ0 20213948 PTHR47651:SF17 NAD-DEPENDENT HISTONE DEACETYLASE HST4 DEACETYLASE SIRTUIN-TYPE DOMAIN-CONTAINING PROTEIN histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG190647|UniProtKB=T1FS60 T1FS60 20211657 PTHR10665:SF0 RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS SUPPRESSOR OF HAIRLESS PROTEIN cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 Notch signaling pathway#P00045>Su(H)#P01101;Alzheimer disease-presenilin pathway#P00004>CSL#P00158;Angiogenesis#P00005>CSL#P00233 HELRO|EnsemblGenome=HelroG194195|UniProtKB=T1FVS5 T1FVS5 20212921 PTHR44442:SF1 3-KETO-STEROID REDUCTASE 3-KETO-STEROID REDUCTASE_17-BETA-HYDROXYSTEROID DEHYDROGENASE 7 oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 sterol metabolic process#GO:0016125;organic hydroxy compound metabolic process#GO:1901615;lipid metabolic process#GO:0006629;steroid metabolic process#GO:0008202;organic cyclic compound metabolic process#GO:1901360;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 reductase#PC00198;metabolite interconversion enzyme#PC00262 Androgen/estrogene/progesterone biosynthesis#P02727>Estradiol 17beta-dehydrogenase#P02826 HELRO|EnsemblGenome=HelroG79877|UniProtKB=T1G3U7 T1G3U7 20215745 PTHR22798:SF0 MCT-1 PROTEIN MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1 cellular component biogenesis#GO:0044085;peptide metabolic process#GO:0006518;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;translation#GO:0006412;protein-RNA complex assembly#GO:0022618;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cytoplasmic translation#GO:0002181;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;cytoplasmic translational initiation#GO:0002183;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;cellular component organization or biogenesis#GO:0071840;peptide biosynthetic process#GO:0043043;protein-containing complex organization#GO:0043933;ribonucleoprotein complex biogenesis#GO:0022613;translational initiation#GO:0006413;protein-RNA complex organization#GO:0071826 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG181735|UniProtKB=T1FH97 T1FH97 20208196 PTHR31206:SF1 LP10445P LP10445P HELRO|EnsemblGenome=HelroG76349|UniProtKB=T1G2I7 T1G2I7 20215285 PTHR42753:SF10 MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER PROLINE--TRNA LIGASE, MITOCHONDRIAL-RELATED catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG78348|UniProtKB=T1G3A8 T1G3A8 20215556 PTHR45080:SF8 CONTACTIN 5 IG-LIKE DOMAIN-CONTAINING PROTEIN cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG106717|UniProtKB=T1EE42 T1EE42 20194844 PTHR13045:SF0 5'-NUCLEOTIDASE 7-METHYLGUANOSINE PHOSPHATE-SPECIFIC 5'-NUCLEOTIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;5'-nucleotidase activity#GO:0008253;catalytic activity#GO:0003824;nucleotidase activity#GO:0008252;phosphoric ester hydrolase activity#GO:0042578 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 esterase#PC00097 HELRO|EnsemblGenome=HelroG185895|UniProtKB=T1FNE8 T1FNE8 20210345 PTHR24250:SF27 CHYMOTRYPSIN-RELATED ELASTASE 2 LIKE hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG180636|UniProtKB=T1FG40 T1FG40 20207789 PTHR46538:SF3 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161350|UniProtKB=T1ERD6 T1ERD6 20199136 PTHR47027:SF25 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174965|UniProtKB=T1F8N6 T1F8N6 20205185 PTHR11360:SF260 MONOCARBOXYLATE TRANSPORTER MFS DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;monocarboxylic acid transmembrane transporter activity#GO:0008028;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;monocarboxylic acid transport#GO:0015718;establishment of localization#GO:0051234;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942 transporter#PC00227 HELRO|EnsemblGenome=HelroG177346|UniProtKB=T1FBJ4 T1FBJ4 20206193 PTHR10985:SF77 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED GH26014P sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of multicellular organismal process#GO:0051239;regulation of cell development#GO:0060284;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regionalization#GO:0003002;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of RNA biosynthetic process#GO:2001141;regulation of multicellular organismal development#GO:2000026;regulation of cell differentiation#GO:0045595;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of neurogenesis#GO:0050767;regulation of macromolecule metabolic process#GO:0060255;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;regulation of nervous system development#GO:0051960;biological regulation#GO:0065007;anterior/posterior pattern specification#GO:0009952;multicellular organismal process#GO:0032501;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;pattern specification process#GO:0007389;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG188864|UniProtKB=T1FQF1 T1FQF1 20211048 PTHR24304:SF4 CYTOCHROME P450 FAMILY 7 CYTOCHROME P450 steroid hydroxylase activity#GO:0008395;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497 organic acid biosynthetic process#GO:0016053;organic hydroxy compound metabolic process#GO:1901615;oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;monocarboxylic acid biosynthetic process#GO:0072330;cellular metabolic process#GO:0044237;homeostatic process#GO:0042592;cellular biosynthetic process#GO:0044249;organic hydroxy compound biosynthetic process#GO:1901617;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;chemical homeostasis#GO:0048878;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;organic acid metabolic process#GO:0006082;cholesterol homeostasis#GO:0042632;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;steroid metabolic process#GO:0008202;organic cyclic compound metabolic process#GO:1901360;lipid homeostasis#GO:0055088;small molecule biosynthetic process#GO:0044283;carboxylic acid metabolic process#GO:0019752;steroid biosynthetic process#GO:0006694;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG101766|UniProtKB=T1ED69 T1ED69 20194521 PTHR15948:SF0 G-PROTEIN COUPLED RECEPTOR 89-RELATED GOLGI PH REGULATOR A-RELATED G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG82139|UniProtKB=T1G4N5 T1G4N5 20216033 PTHR22939:SF129 SERINE PROTEASE FAMILY S1C HTRA-RELATED SERINE PROTEASE HTRA2, MITOCHONDRIAL serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG192245|UniProtKB=T1FTR5 T1FTR5 20212212 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG181968|UniProtKB=T1FHJ4 T1FHJ4 20208293 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185429|UniProtKB=T1FMT3 T1FMT3 20210132 PTHR11937:SF31 ACTIN ACTIN-RELATED PROTEIN 3 cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;Arp2/3 complex-mediated actin nucleation#GO:0034314;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;Arp2/3 protein complex#GO:0005885;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 actin and actin related protein#PC00039;cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Huntington disease#P00029>Actin#P00807 HELRO|EnsemblGenome=HelroG157379|UniProtKB=T1EMA5 T1EMA5 20197705 PTHR24250:SF27 CHYMOTRYPSIN-RELATED ELASTASE 2 LIKE hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG87296|UniProtKB=T1G6N8 T1G6N8 20216735 PTHR24006:SF758 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36 cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG170197|UniProtKB=T1F2S0 T1F2S0 20203119 PTHR24250:SF67 CHYMOTRYPSIN-RELATED PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG148427|UniProtKB=T1EK82 T1EK82 20196982 PTHR23050:SF523 CALCIUM BINDING PROTEIN CALMODULIN cation binding#GO:0043169;small molecule binding#GO:0036094;molecular function regulator activity#GO:0098772;binding#GO:0005488;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;enzyme regulator activity#GO:0030234 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061 B cell activation#P00010>Calmodulin#P00375;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Calmodulin#P00755;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716;T cell activation#P00053>Calmodulin#P01305 HELRO|EnsemblGenome=HelroG190894|UniProtKB=T1FSE5 T1FSE5 20211742 PTHR45762:SF3 ZINC FINGER RNA-BINDING PROTEIN ZINC-FINGER PROTEIN AT 72D, ISOFORM B RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG164694|UniProtKB=T1EVQ5 T1EVQ5 20200655 PTHR28489:SF2 RENTINAL DEGENERATION 3-LIKE RENTINAL DEGENERATION 3-LIKE HELRO|EnsemblGenome=HelroG75858|UniProtKB=T1G2B5 T1G2B5 20215213 PTHR23070:SF110 BCS1 AAA-TYPE ATPASE MITOCHONDRIAL CHAPERONE BCS1 HELRO|EnsemblGenome=HelroG115475|UniProtKB=T1EG85 T1EG85 20195587 PTHR21569:SF16 RIBOSOMAL PROTEIN S9 RIBOSOMAL PROTEIN S16 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;cytosol#GO:0005829;small ribosomal subunit#GO:0015935;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG161493|UniProtKB=T1ERJ7 T1ERJ7 20199197 PTHR47537:SF2 CUBILIN CUBILIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG79936|UniProtKB=T1G3V2 T1G3V2 20215750 PTHR14269:SF60 CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED CARDIOLIPIN SYNTHASE (CMP-FORMING) transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;glycerolipid biosynthetic process#GO:0045017;cardiolipin biosynthetic process#GO:0032049;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;glycerophospholipid metabolic process#GO:0006650;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG112963|UniProtKB=T1EFN6 T1EFN6 20195388 PTHR24104:SF41 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED BRAIN TUMOR PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;mRNA binding#GO:0003729;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;mRNA 3'-UTR binding#GO:0003730 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG79002|UniProtKB=T1G3I1 T1G3I1 20215629 PTHR24346:SF36 MAP/MICROTUBULE AFFINITY-REGULATING KINASE SERINE_THREONINE-PROTEIN KINASE BRSK1 ISOFORM X1-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG70319|UniProtKB=T1G046 T1G046 20214444 PTHR31898:SF1 TRANSMEMBRANE PROTEIN 136 TLC DOMAIN-CONTAINING PROTEIN 5 HELRO|EnsemblGenome=HelroG179602|UniProtKB=T1FEX6 T1FEX6 20207375 PTHR12675:SF12 MUSCLEBLIND-LIKE PROTEIN PROTEIN MUSCLEBLIND nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nitrogen compound metabolic process#GO:0051171;regulation of biosynthetic process#GO:0009889;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG79486|UniProtKB=T1G3P4 T1G3P4 20215692 PTHR10030:SF37 ALPHA-L-FUCOSIDASE ALPHA-L-FUCOSIDASE-RELATED hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 monosaccharide metabolic process#GO:0005996;carbohydrate derivative metabolic process#GO:1901135;glycosyl compound catabolic process#GO:1901658;carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;hexose metabolic process#GO:0019318;glycosyl compound metabolic process#GO:1901657;carbohydrate metabolic process#GO:0005975;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;lysosome#GO:0005764;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;vacuole#GO:0005773;cellular anatomical entity#GO:0110165;lytic vacuole#GO:0000323;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosidase#PC00110;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG185876|UniProtKB=T1FND9 T1FND9 20210336 PTHR43826:SF3 GLUCOSE-6-PHOSPHATE EXCHANGER SLC37A4 GLUCOSE-6-PHOSPHATE EXCHANGER SLC37A4 inorganic molecular entity transmembrane transporter activity#GO:0015318;carbohydrate derivative transmembrane transporter activity#GO:1901505;secondary active transmembrane transporter activity#GO:0015291;antiporter activity#GO:0015297;transmembrane transporter activity#GO:0022857;inorganic anion transmembrane transporter activity#GO:0015103;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215 localization#GO:0051179;inorganic anion transmembrane transport#GO:0098661;organic substance transport#GO:0071702;phosphate ion transport#GO:0006817;organophosphate ester transport#GO:0015748;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264;inorganic anion transport#GO:0015698 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG193024|UniProtKB=T1FUJ2 T1FUJ2 20212488 PTHR21255:SF65 T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN TCTEX1 DOMAIN-CONTAINING PROTEIN 2 protein binding#GO:0005515;binding#GO:0005488 microtubule-based movement#GO:0007018;cellular process#GO:0009987;microtubule-based process#GO:0007017 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;microtubule cytoskeleton#GO:0015630;dynein complex#GO:0030286;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic dynein complex#GO:0005868;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG161665|UniProtKB=T1ERR6 T1ERR6 20199266 PTHR14386:SF2 PROTEIN FAM204A PROTEIN FAM204A HELRO|EnsemblGenome=HelroG186050|UniProtKB=T1FNL6 T1FNL6 20210413 PTHR23122:SF69 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK FI17352P1 cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;cell-cell junction#GO:0005911;anchoring junction#GO:0070161;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG186178|UniProtKB=T1FNS0 T1FNS0 20210467 PTHR22839:SF0 THO COMPLEX SUBUNIT 3 THO3 THO COMPLEX SUBUNIT 3 mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;mRNA transport#GO:0051028;RNA localization#GO:0006403;localization#GO:0051179;organic substance transport#GO:0071702;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;THO complex#GO:0000347;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;transcription export complex#GO:0000346;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG170222|UniProtKB=T1F2T0 T1F2T0 20203129 PTHR46664:SF1 ATM INTERACTOR ATM INTERACTOR sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG166986|UniProtKB=T1EYU6 T1EYU6 20201746 PTHR19269:SF45 TROPOMYOSIN TROPOMYOSIN-1, ISOFORMS 33_34 cytoskeletal protein#PC00085;actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG86926|UniProtKB=T1G6J2 T1G6J2 20216689 PTHR44129:SF13 WD REPEAT-CONTAINING PROTEIN POP1 LISSENCEPHALY-1 HOMOLOG A-RELATED HELRO|EnsemblGenome=HelroG170850|UniProtKB=T1F3I3 T1F3I3 20203382 PTHR12112:SF39 BNIP - RELATED EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN) hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;exopolyphosphatase activity#GO:0004309;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 phosphodiesterase#PC00185;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG116974|UniProtKB=T1EGJ0 T1EGJ0 20195692 PTHR10859:SF91 GLYCOSYL TRANSFERASE DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein glycosylation#GO:0006486;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;protein metabolic process#GO:0019538;glycosylation#GO:0070085;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG109800|UniProtKB=T1EEW4 T1EEW4 20195116 PTHR10947:SF0 PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47 PHENYLALANINE--TRNA LIGASE BETA SUBUNIT catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG88036|UniProtKB=T1G6X6 T1G6X6 20216823 PTHR11561:SF0 PHOSPHOENOLPYRUVATE CARBOXYKINASE PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP]-RELATED cation binding#GO:0043169;carboxy-lyase activity#GO:0016831;carbon-carbon lyase activity#GO:0016830;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;lyase activity#GO:0016829;ion binding#GO:0043167 dicarboxylic acid metabolic process#GO:0043648;alcohol biosynthetic process#GO:0046165;lipid catabolic process#GO:0016042;response to extracellular stimulus#GO:0009991;acylglycerol metabolic process#GO:0006639;lipid biosynthetic process#GO:0008610;neutral lipid metabolic process#GO:0006638;triglyceride biosynthetic process#GO:0019432;carboxylic acid catabolic process#GO:0046395;cellular lipid catabolic process#GO:0044242;organic substance metabolic process#GO:0071704;organic hydroxy compound metabolic process#GO:1901615;oxoacid metabolic process#GO:0043436;response to oxygen-containing compound#GO:1901700;cellular response to organic substance#GO:0071310;cellular metabolic process#GO:0044237;alcohol metabolic process#GO:0006066;intracellular chemical homeostasis#GO:0055082;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;hexose biosynthetic process#GO:0019319;organic acid catabolic process#GO:0016054;response to glucose#GO:0009749;small molecule catabolic process#GO:0044282;response to stress#GO:0006950;small molecule biosynthetic process#GO:0044283;carbohydrate homeostasis#GO:0033500;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329;lipid metabolic process#GO:0006629;monosaccharide metabolic process#GO:0005996;response to lipid#GO:0033993;organic hydroxy compound biosynthetic process#GO:1901617;biosynthetic process#GO:0009058;cellular homeostasis#GO:0019725;cellular response to oxygen-containing compound#GO:1901701;glycerolipid metabolic process#GO:0046486;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carbohydrate metabolic process#GO:0005975;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;response to organic substance#GO:0010033;carbohydrate biosynthetic process#GO:0016051;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;triglyceride metabolic process#GO:0006641;glycerolipid biosynthetic process#GO:0045017;glucose homeostasis#GO:0042593;homeostatic process#GO:0042592;cellular biosynthetic process#GO:0044249;response to nutrient levels#GO:0031667;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;chemical homeostasis#GO:0048878;glucose metabolic process#GO:0006006;fatty acid catabolic process#GO:0009062;response to external stimulus#GO:0009605;response to stimulus#GO:0050896;intracellular glucose homeostasis#GO:0001678;fatty acid metabolic process#GO:0006631;response to chemical#GO:0042221;response to starvation#GO:0042594;hexose metabolic process#GO:0019318;cellular lipid metabolic process#GO:0044255;carboxylic acid metabolic process#GO:0019752 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 kinase#PC00137 Pyruvate metabolism#P02772>Phosphoenolpyruvate Carboxykinase#P03135 HELRO|EnsemblGenome=HelroG71683|UniProtKB=T1G0Q2 T1G0Q2 20214650 PTHR11662:SF399 SOLUTE CARRIER FAMILY 17 FI19708P1-RELATED secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG166479|UniProtKB=T1EY63 T1EY63 20201513 PTHR22588:SF3 VWFA DOMAIN-CONTAINING PROTEIN VWFA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168850|UniProtKB=T1F115 T1F115 20202515 PTHR47641:SF13 PERIAXIN-LIKE YALI0B18194P HELRO|EnsemblGenome=HelroG163376|UniProtKB=T1ETZ2 T1ETZ2 20200042 PTHR11361:SF20 DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER MUTS PROTEIN HOMOLOG 5 nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;homologous chromosome segregation#GO:0045143;nuclear division#GO:0000280;cell cycle process#GO:0022402;nucleobase-containing compound metabolic process#GO:0006139;chromosome segregation#GO:0007059;reciprocal homologous recombination#GO:0140527;chromosome organization involved in meiotic cell cycle#GO:0070192;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;meiotic cell cycle process#GO:1903046;meiosis I cell cycle process#GO:0061982;reproductive process#GO:0022414;reciprocal meiotic recombination#GO:0007131;meiosis I#GO:0007127;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;nuclear chromosome segregation#GO:0098813;macromolecule metabolic process#GO:0043170;meiotic cell cycle#GO:0051321;homologous chromosome pairing at meiosis#GO:0007129;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;meiotic chromosome segregation#GO:0045132;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;reproduction#GO:0000003;meiotic nuclear division#GO:0140013;organelle organization#GO:0006996;chromosome organization#GO:0051276;sexual reproduction#GO:0019953;cell cycle#GO:0007049;organelle fission#GO:0048285;homologous recombination#GO:0035825;DNA metabolic process#GO:0006259 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG91019|UniProtKB=T1G7Y7 T1G7Y7 20217184 PTHR19229:SF250 ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;lipid transporter activity#GO:0005319;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;organic substance transport#GO:0071702;lipid localization#GO:0010876;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;lipid transport#GO:0006869;transport#GO:0006810 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG139996|UniProtKB=T1EIZ6 T1EIZ6 20196546 PTHR22600:SF21 BETA-HEXOSAMINIDASE BETA-HEXOSAMINIDASE A hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 glycosaminoglycan metabolic process#GO:0030203;carbohydrate derivative metabolic process#GO:1901135;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;aminoglycan metabolic process#GO:0006022;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;membrane#GO:0016020 glycosidase#PC00110;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG173373|UniProtKB=T1F6Q7 T1F6Q7 20204506 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169643|UniProtKB=T1F273 T1F273 20202923 PTHR19269:SF45 TROPOMYOSIN TROPOMYOSIN-1, ISOFORMS 33_34 cytoskeletal protein#PC00085;actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG115447|UniProtKB=T1EG82 T1EG82 20195584 PTHR22968:SF24 PROTEIN KINASE C, MU SERINE_THREONINE-PROTEIN KINASE transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;signaling#GO:0023052 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 VEGF signaling pathway#P00056>PKC#P01425;Angiogenesis#P00005>PKC#P00219;EGF receptor signaling pathway#P00018>PKC#P00565 HELRO|EnsemblGenome=HelroG123271|UniProtKB=T1EGX4 T1EGX4 20195824 PTHR11579:SF9 PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE transferase activity#GO:0016740;O-methyltransferase activity#GO:0008171;catalytic activity#GO:0003824;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a protein#GO:0140096;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein methyltransferase activity#GO:0008276 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG67925|UniProtKB=T1FZ78 T1FZ78 20214126 PTHR22749:SF6 RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE RIBOFLAVIN KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;nucleoside monophosphate metabolic process#GO:0009123;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribonucleoside monophosphate metabolic process#GO:0009161;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 Flavin biosynthesis#P02741>Riboflavin kinase#P02934;Flavin biosynthesis#P02741>FAD synthetase#P02936 HELRO|EnsemblGenome=HelroG168041|UniProtKB=T1F038 T1F038 20202188 PTHR24280:SF4 CYTOCHROME P450 20A1 CYTOCHROME P450 20A1 cellular anatomical entity#GO:0110165;membrane#GO:0016020 oxygenase#PC00177 HELRO|EnsemblGenome=HelroG106126|UniProtKB=T1EE03 T1EE03 20194805 PTHR42861:SF127 CALCIUM-TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE SARCOPLASMIC_ENDOPLASMIC RETICULUM TYPE calcium ion transmembrane transporter activity#GO:0015085;inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;P-type ion transporter activity#GO:0015662;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;inorganic cation transmembrane transporter activity#GO:0022890;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;calcium ion transport#GO:0006816;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;membrane#GO:0016020 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG189246|UniProtKB=T1FQV1 T1FQV1 20211198 PTHR24416:SF566 TYROSINE-PROTEIN KINASE RECEPTOR EPIDERMAL GROWTH FACTOR RECEPTOR signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 negative regulation of biological process#GO:0048519;signal transduction#GO:0007165;neurogenesis#GO:0022008;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;positive regulation of cell population proliferation#GO:0008284;regulation of catalytic activity#GO:0050790;nervous system development#GO:0007399;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;system development#GO:0048731;cell differentiation#GO:0030154;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;negative regulation of programmed cell death#GO:0043069;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;regulation of programmed cell death#GO:0043067;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;cellular developmental process#GO:0048869;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;regulation of apoptotic process#GO:0042981;regulation of cell population proliferation#GO:0042127;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;negative regulation of apoptotic process#GO:0043066;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;anatomical structure development#GO:0048856;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 basal plasma membrane#GO:0009925;receptor complex#GO:0043235;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;basal part of cell#GO:0045178;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 EGF receptor signaling pathway#P00018>EGFR#P00542;Cadherin signaling pathway#P00012>EGFR#P00466 HELRO|EnsemblGenome=HelroG187050|UniProtKB=T1FP63 T1FP63 20210610 PTHR24221:SF503 ATP-BINDING CASSETTE SUB-FAMILY B MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG164405|UniProtKB=T1EVD9 T1EVD9 20200539 PTHR46618:SF1 ARMADILLO REPEAT-CONTAINING PROTEIN 3 ARMADILLO REPEAT-CONTAINING PROTEIN 3 HELRO|EnsemblGenome=HelroG185877|UniProtKB=T1FNE0 T1FNE0 20210337 PTHR21106:SF2 NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 6 NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 6 HELRO|EnsemblGenome=HelroG80342|UniProtKB=T1G3Z7 T1G3Z7 20215795 PTHR12436:SF3 80 KDA MCM3-ASSOCIATED PROTEIN GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;mRNA transport#GO:0051028;RNA localization#GO:0006403;localization#GO:0051179;organic substance transport#GO:0071702;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;transcription export complex 2#GO:0070390;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG177167|UniProtKB=T1FBB0 T1FBB0 20206109 PTHR31797:SF6 EXTRACELLULAR MATRIX PROTEIN A-RELATED CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157417|UniProtKB=T1EMB2 T1EMB2 20197712 PTHR11655:SF16 60S/50S RIBOSOMAL PROTEIN L6/L9 60S RIBOSOMAL PROTEIN L9 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cytoplasmic translation#GO:0002181;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG174536|UniProtKB=T1F883 T1F883 20205032 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG155903|UniProtKB=T1ELP1 T1ELP1 20197491 PTHR21255:SF4 T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN DYNEIN LIGHT CHAIN TCTEX-TYPE protein binding#GO:0005515;binding#GO:0005488 microtubule-based movement#GO:0007018;cellular process#GO:0009987;microtubule-based process#GO:0007017 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;microtubule cytoskeleton#GO:0015630;dynein complex#GO:0030286;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic dynein complex#GO:0005868;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG81331|UniProtKB=T1G4D2 T1G4D2 20215930 PTHR19269:SF45 TROPOMYOSIN TROPOMYOSIN-1, ISOFORMS 33_34 cytoskeletal protein#PC00085;actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG183457|UniProtKB=T1FJP6 T1FJP6 20209045 PTHR12766:SF7 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DEATH DOMAIN-ASSOCIATED PROTEIN 6 FAS signaling pathway#P00020>DAXX#P00602;Apoptosis signaling pathway#P00006>DAXX#P00296 HELRO|EnsemblGenome=HelroG101910|UniProtKB=T1ED74 T1ED74 20194526 PTHR21294:SF8 ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG184659|UniProtKB=T1FLP8 T1FLP8 20209747 PTHR21207:SF2 PARKIN COREGULATED GENE PROTEIN PARK2 COREGULATED PARKIN COREGULATED GENE PROTEIN heat shock protein binding#GO:0031072;protein binding#GO:0005515;protein-folding chaperone binding#GO:0051087;binding#GO:0005488;Hsp70 protein binding#GO:0030544;Hsp90 protein binding#GO:0051879 HELRO|EnsemblGenome=HelroG137851|UniProtKB=T1EIP2 T1EIP2 20196442 PTHR11849:SF304 ETS DNA-BINDING PROTEIN D-ETS-3 transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG170028|UniProtKB=T1F2K1 T1F2K1 20203050 PTHR20371:SF1 ENOLASE-PHOSPHATASE E1 ENOLASE-PHOSPHATASE E1 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;sulfur compound metabolic process#GO:0006790;proteinogenic amino acid biosynthetic process#GO:0170038;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;aspartate family amino acid biosynthetic process#GO:0009067;alpha-amino acid biosynthetic process#GO:1901607;nitrogen compound metabolic process#GO:0006807;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;aspartate family amino acid metabolic process#GO:0009066;small molecule biosynthetic process#GO:0044283;L-amino acid biosynthetic process#GO:0170034;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG183617|UniProtKB=T1FJX9 T1FJX9 20209128 PTHR34153:SF2 SI:CH211-262H13.3-RELATED-RELATED SI:CH211-262H13.3-RELATED HELRO|EnsemblGenome=HelroG85674|UniProtKB=T1G614 T1G614 20216511 PTHR10264:SF127 BAND 7 PROTEIN-RELATED PODOCIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG68867|UniProtKB=T1FZK6 T1FZK6 20214254 PTHR45080:SF8 CONTACTIN 5 IG-LIKE DOMAIN-CONTAINING PROTEIN cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG113568|UniProtKB=T1EFT7 T1EFT7 20195439 PTHR18934:SF91 ATP-DEPENDENT RNA HELICASE PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640 cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG191329|UniProtKB=T1FSW2 T1FSW2 20211909 PTHR45838:SF4 HISTONE-LYSINE-N-METHYLTRANSFERASE 2 KMT2 FAMILY MEMBER HISTONE-LYSINE N-METHYLTRANSFERASE TRITHORAX N-methyltransferase activity#GO:0008170;histone modifying activity#GO:0140993;histone H3K4 methyltransferase activity#GO:0042800;transferase activity#GO:0016740;catalytic activity#GO:0003824;histone methyltransferase activity#GO:0042054;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;protein-lysine N-methyltransferase activity#GO:0016279;catalytic activity, acting on a protein#GO:0140096;lysine N-methyltransferase activity#GO:0016278;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein methyltransferase activity#GO:0008276 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;histone methyltransferase complex#GO:0035097;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;methyltransferase complex#GO:0034708;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG172841|UniProtKB=T1F600 T1F600 20204249 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG72781|UniProtKB=T1G155 T1G155 20214803 PTHR24012:SF885 RNA BINDING PROTEIN EG:132E8.1 PROTEIN-RELATED nucleic acid binding#GO:0003676;single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159;mRNA binding#GO:0003729;poly(A) binding#GO:0008143;mRNA 3'-UTR binding#GO:0003730 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG188506|UniProtKB=T1FQ25 T1FQ25 20210922 PTHR11662:SF399 SOLUTE CARRIER FAMILY 17 FI19708P1-RELATED secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG175767|UniProtKB=T1F9M5 T1F9M5 20205524 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159136|UniProtKB=T1ENM9 T1ENM9 20198179 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED FMRFAMIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG108184|UniProtKB=T1EEG5 T1EEG5 20194967 PTHR12276:SF45 EPSIN/ENT-RELATED CLATHRIN INTERACTOR 1 protein binding#GO:0005515;lipid binding#GO:0008289;clathrin binding#GO:0030276;phospholipid binding#GO:0005543;binding#GO:0005488 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;import into cell#GO:0098657;transport#GO:0006810;endocytosis#GO:0006897 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;clathrin vesicle coat#GO:0030125;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;vesicle coat#GO:0030120;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;clathrin-coated vesicle#GO:0030136;endomembrane system#GO:0012505;membrane coat#GO:0030117;coated vesicle membrane#GO:0030662;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;coated membrane#GO:0048475;cytoplasmic vesicle membrane#GO:0030659;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG112437|UniProtKB=T1EFJ9 T1EFJ9 20195351 PTHR11819:SF195 SOLUTE CARRIER FAMILY 5 SODIUM_GLUCOSE COTRANSPORTER 4 inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;carbohydrate transmembrane transporter activity#GO:0015144;symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;sugar transmembrane transporter activity#GO:0051119;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;monoatomic ion transmembrane transporter activity#GO:0015075;inorganic cation transmembrane transporter activity#GO:0022890;solute:monoatomic cation symporter activity#GO:0015294 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG65386|UniProtKB=T1FY70 T1FY70 20213768 PTHR18952:SF265 CARBONIC ANHYDRASE CARBONIC ANHYDRASE dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG67495|UniProtKB=T1FZ18 T1FZ18 20214066 PTHR24208:SF105 LIM/HOMEOBOX PROTEIN LHX DLIM1 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;neurogenesis#GO:0022008;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;system development#GO:0048731;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;regulation of macromolecule biosynthetic process#GO:0010556;generation of neurons#GO:0048699;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG184399|UniProtKB=T1FL44 T1FL44 20209543 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG88883|UniProtKB=T1G772 T1G772 20216919 PTHR45722:SF2 60S RIBOSOMAL PROTEIN L35 LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of LSU-rRNA#GO:0000470;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG167287|UniProtKB=T1EZ80 T1EZ80 20201880 PTHR19265:SF0 MEIOSIS-SPECIFIC NUCLEAR STRUCTURAL PROTEIN 1 MEIOSIS-SPECIFIC NUCLEAR STRUCTURAL PROTEIN 1 structural protein#PC00211 HELRO|EnsemblGenome=HelroG183483|UniProtKB=T1FJR0 T1FJR0 20209059 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184156|UniProtKB=T1FKP3 T1FKP3 20209392 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG189400|UniProtKB=T1FR10 T1FR10 20211257 PTHR14633:SF3 LITTLE ELONGATION COMPLEX SUBUNIT 2 LITTLE ELONGATION COMPLEX SUBUNIT 2 positive regulation of nitrogen compound metabolic process#GO:0051173;cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;positive regulation of RNA biosynthetic process#GO:1902680;RNA metabolic process#GO:0016070;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;gene expression#GO:0010467;regulation of RNA biosynthetic process#GO:2001141;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;positive regulation of metabolic process#GO:0009893;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;cellular nitrogen compound biosynthetic process#GO:0044271;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;transcription by RNA polymerase III#GO:0006383;snRNA metabolic process#GO:0016073;snRNA transcription by RNA polymerase II#GO:0042795;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;regulation of DNA-templated transcription#GO:0006355;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;positive regulation of cellular biosynthetic process#GO:0031328;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;organic cyclic compound biosynthetic process#GO:1901362;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;heterocycle biosynthetic process#GO:0018130;regulation of primary metabolic process#GO:0080090;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;ncRNA transcription#GO:0098781;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;transcription by RNA polymerase II#GO:0006366;regulation of cellular metabolic process#GO:0031323 HELRO|EnsemblGenome=HelroG97197|UniProtKB=T1G9F9 T1G9F9 20217706 PTHR24058:SF112 DUAL SPECIFICITY PROTEIN KINASE DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 3 HOMOLOG-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;peptidyl-threonine phosphorylation#GO:0018107;nitrogen compound metabolic process#GO:0006807;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG183345|UniProtKB=T1FJH4 T1FJH4 20208973 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;heme binding#GO:0020037 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG85096|UniProtKB=T1G5S7 T1G5S7 20216424 PTHR23048:SF0 MYOSIN LIGHT CHAIN 1, 3 CALMODULIN LIKE 3 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;myosin complex#GO:0016459;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG112561|UniProtKB=T1EFK7 T1EFK7 20195359 PTHR22883:SF405 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular localization#GO:0051641;macromolecule localization#GO:0033036;macromolecule modification#GO:0043412;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;protein palmitoylation#GO:0018345;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;localization within membrane#GO:0051668;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein localization to membrane#GO:0072657;organonitrogen compound biosynthetic process#GO:1901566;protein targeting#GO:0006605;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;protein acylation#GO:0043543;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipoprotein biosynthetic process#GO:0042158;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;lipoprotein metabolic process#GO:0042157 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG79655|UniProtKB=T1G3R8 T1G3R8 20215716 PTHR47611:SF3 HAT DIMERISATION DOMAIN, C-TERMINAL HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183439|UniProtKB=T1FJN5 T1FJN5 20209034 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192915|UniProtKB=T1FUF3 T1FUF3 20212449 PTHR24107:SF2 YNEIN REGULATORY COMPLEX SUBUNIT 5 NLR FAMILY CARD DOMAIN CONTAINING 3 non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG66729|UniProtKB=T1FYP7 T1FYP7 20213945 PTHR48013:SF15 DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;MAPK cascade#GO:0000165;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Integrin signalling pathway#P00034>Jnk#P00951;FAS signaling pathway#P00020>MKK4#P00610;p38 MAPK pathway#P05918>MKK4#P06034;Huntington disease#P00029>MAPKK4#P00787;Ras Pathway#P04393>MKK4/7#P04565;Gonadotropin-releasing hormone receptor pathway#P06664>MKK4/7#P06760;Huntington disease#P00029>SEK-1#P00792;Apoptosis signaling pathway#P00006>SEK1#P00266;Angiogenesis#P00005>JNKK1#P00199;Toll receptor signaling pathway#P00054>MKK4#P01366;FGF signaling pathway#P00021>MKK4,7#P00637;Integrin signalling pathway#P00034>MEK#P00925;EGF receptor signaling pathway#P00018>MKK4,7#P00555;Oxidative stress response#P00046>MKK4#P01138;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>MEK#P00891 HELRO|EnsemblGenome=HelroG166955|UniProtKB=T1EYT1 T1EYT1 20201731 PTHR31196:SF2 RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED HELRO|EnsemblGenome=HelroG166966|UniProtKB=T1EYT7 T1EYT7 20201737 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG65165|UniProtKB=T1FY40 T1FY40 20213738 PTHR22891:SF174 EUKARYOTIC TRANSLATION INITIATION FACTOR 2C ARGONAUTE-1, ISOFORM A catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;nuclease activity#GO:0004518;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;endonuclease activity#GO:0004519;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG90491|UniProtKB=T1G7S1 T1G7S1 20217118 PTHR46314:SF2 SOLUTE CARRIER FAMILY 25 MEMBER 44 SOLUTE CARRIER FAMILY 25 MEMBER 44 transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;branched-chain amino acid transmembrane transporter activity#GO:0015658;amino acid transmembrane transporter activity#GO:0015171;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;establishment of localization#GO:0051234;amino acid transport#GO:0006865;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;branched-chain amino acid transport#GO:0015803;nitrogen compound transport#GO:0071705;carboxylic acid transport#GO:0046942 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG165102|UniProtKB=T1EWA8 T1EWA8 20200858 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165232|UniProtKB=T1EWH1 T1EWH1 20200921 PTHR31735:SF1 VACUOLAR MEMBRANE PROTEIN YPL162C VACUOLAR MEMBRANE PROTEIN YPL162C cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG181283|UniProtKB=T1FGU3 T1FGU3 20208042 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163763|UniProtKB=T1EUF8 T1EUF8 20200208 PTHR13703:SF54 SMAD MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG cis-regulatory region sequence-specific DNA binding#GO:0000987;SMAD binding#GO:0046332;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;molecular function regulator activity#GO:0098772;binding#GO:0005488;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;protein binding#GO:0005515;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;molecular function inhibitor activity#GO:0140678 signal transduction#GO:0007165;regulation of nitrogen compound metabolic process#GO:0051171;response to growth factor#GO:0070848;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;cellular response to BMP stimulus#GO:0071773;cell differentiation#GO:0030154;response to endogenous stimulus#GO:0009719;anatomical structure morphogenesis#GO:0009653;regulation of biosynthetic process#GO:0009889;response to BMP#GO:0071772;regulation of macromolecule biosynthetic process#GO:0010556;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;regulation of gene expression#GO:0010468;signaling#GO:0023052;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;cellular response to endogenous stimulus#GO:0071495;regulation of DNA-templated transcription#GO:0006355;BMP signaling pathway#GO:0030509;cell communication#GO:0007154;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;cellular response to growth factor stimulus#GO:0071363;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;cell surface receptor signaling pathway#GO:0007166;anatomical structure development#GO:0048856;transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0007178;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 TGF-beta signaling pathway#P00052>RSmads#P01292 HELRO|EnsemblGenome=HelroG93038|UniProtKB=T1G8R6 T1G8R6 20217463 PTHR10064:SF31 60S RIBOSOMAL PROTEIN L22 LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cytoplasmic translation#GO:0002181;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;translation#GO:0006412;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG162723|UniProtKB=T1ET19 T1ET19 20199719 PTHR21330:SF1 E3 SUMO-PROTEIN LIGASE NSE2 E3 SUMO-PROTEIN LIGASE NSE2 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;SUMO transferase activity#GO:0019789;SUMO ligase activity#GO:0061665;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;double-strand break repair#GO:0006302;macromolecule modification#GO:0043412;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;post-translational protein modification#GO:0043687;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;recombinational repair#GO:0000725;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;protein modification by small protein conjugation or removal#GO:0070647;macromolecule metabolic process#GO:0043170;protein sumoylation#GO:0016925;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;double-strand break repair via homologous recombination#GO:0000724;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;catalytic complex#GO:1902494;transferase complex#GO:1990234;condensed chromosome#GO:0000793;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG176240|UniProtKB=T1FAB7 T1FAB7 20205766 PTHR33332:SF48 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189446|UniProtKB=T1FR25 T1FR25 20211272 PTHR22765:SF416 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE GODZILLA transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG186077|UniProtKB=T1FNM9 T1FNM9 20210426 PTHR11711:SF30 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR 1 carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 G-protein#PC00020 Integrin signalling pathway#P00034>Arf1#P00923;Huntington disease#P00029>ARF#P00786 HELRO|EnsemblGenome=HelroG160642|UniProtKB=T1EQJ5 T1EQJ5 20198845 PTHR10258:SF8 CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA CALCIUM-ACTIVATED POTASSIUM CHANNEL BK ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;molecular function regulator activity#GO:0098772;transporter regulator activity#GO:0141108;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic ion-gated channel activity#GO:0022839;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium-activated cation channel activity#GO:0005227;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;potassium channel regulator activity#GO:0015459;ligand-gated monoatomic cation channel activity#GO:0099094;channel regulator activity#GO:0016247;monoatomic ion channel activity#GO:0005216;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 detection of stimulus#GO:0051606;response to stimulus#GO:0050896;response to chemical#GO:0042221;detection of chemical stimulus#GO:0009593 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG190154|UniProtKB=T1FRR0 T1FRR0 20211507 PTHR15431:SF9 FGFR1 ONCOGENE PARTNER/LISH DOMAIN-CONTAINING PROTEIN CENTROSOMAL PROTEIN 43 HELRO|EnsemblGenome=HelroG193707|UniProtKB=T1FVA3 T1FVA3 20212749 PTHR23044:SF61 3'-5' EXONUCLEASE ERI1-RELATED 3'-5' EXORIBONUCLEASE 1-RELATED RNA metabolism protein#PC00031;exoribonuclease#PC00099 HELRO|EnsemblGenome=HelroG79849|UniProtKB=T1G3U4 T1G3U4 20215742 PTHR24637:SF428 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HELRO|EnsemblGenome=HelroG88781|UniProtKB=T1G763 T1G763 20216910 PTHR15243:SF0 SERINE/THREONINE-PROTEIN KINASE 19 SERINE_THREONINE-PROTEIN KINASE 19 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG86343|UniProtKB=T1G6A8 T1G6A8 20216605 PTHR34929:SF1 ZGC:153157 INAF MOTIF CONTAINING 2 HELRO|EnsemblGenome=HelroG157983|UniProtKB=T1EMI5 T1EMI5 20197785 PTHR10663:SF375 GUANYL-NUCLEOTIDE EXCHANGE FACTOR LD29171P guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG160156|UniProtKB=T1EPW6 T1EPW6 20198616 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190099|UniProtKB=T1FRP3 T1FRP3 20211490 PTHR14429:SF22 FIBROSIN FAMILY MEMBER AGAP013055-PA HELRO|EnsemblGenome=HelroG185538|UniProtKB=T1FMY1 T1FMY1 20210180 PTHR11808:SF15 TRANS-SULFURATION ENZYME FAMILY MEMBER CYSTATHIONINE GAMMA-LYASE small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;lyase activity#GO:0016829;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;sulfur compound metabolic process#GO:0006790;proteinogenic amino acid biosynthetic process#GO:0170038;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;alpha-amino acid biosynthetic process#GO:1901607;nitrogen compound metabolic process#GO:0006807;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;small molecule biosynthetic process#GO:0044283;L-amino acid biosynthetic process#GO:0170034;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 lyase#PC00144 Methionine biosynthesis#P02753>O-Succinyl homoserine lyase#P03026 HELRO|EnsemblGenome=HelroG173298|UniProtKB=T1F6N3 T1F6N3 20204482 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG133632|UniProtKB=T1EI18 T1EI18 20196218 PTHR19300:SF30 BETA-1,4-GALACTOSYLTRANSFERASE BETA-1,4-GALACTOSYLTRANSFERASE 7 galactosyltransferase activity#GO:0008378;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycosylation#GO:0070085;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 Wnt signaling pathway#P00057>Calcineurin#P01446 HELRO|EnsemblGenome=HelroG160127|UniProtKB=T1EPU4 T1EPU4 20198594 PTHR21041:SF9 DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180983|UniProtKB=T1FGH8 T1FGH8 20207927 PTHR21227:SF0 TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2 TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2 endonuclease activity#GO:0004519;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 endodeoxyribonuclease#PC00093 HELRO|EnsemblGenome=HelroG157575|UniProtKB=T1EMD3 T1EMD3 20197733 PTHR11902:SF1 ENOLASE ENOLASE lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;ribonucleoside triphosphate metabolic process#GO:0009199;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative metabolic process#GO:1901135;heterocycle catabolic process#GO:0046700;organonitrogen compound catabolic process#GO:1901565;ribonucleotide catabolic process#GO:0009261;pyridine nucleotide metabolic process#GO:0019362;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;cellular nitrogen compound catabolic process#GO:0044270;purine-containing compound catabolic process#GO:0072523;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;purine nucleotide catabolic process#GO:0006195;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;purine ribonucleotide catabolic process#GO:0009154;nucleoside phosphate metabolic process#GO:0006753;carbohydrate catabolic process#GO:0016052;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;catabolic process#GO:0009056;nucleoside diphosphate metabolic process#GO:0009132;organic substance catabolic process#GO:1901575;carbohydrate metabolic process#GO:0005975;purine nucleotide metabolic process#GO:0006163;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;oxoacid metabolic process#GO:0043436;nucleoside phosphate catabolic process#GO:1901292;carbohydrate derivative catabolic process#GO:1901136;purine ribonucleoside triphosphate metabolic process#GO:0009205;generation of precursor metabolites and energy#GO:0006091;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;nucleotide catabolic process#GO:0009166;cellular nitrogen compound metabolic process#GO:0034641;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;nucleoside diphosphate catabolic process#GO:0009134;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;organophosphate catabolic process#GO:0046434;aromatic compound catabolic process#GO:0019439;glycolytic process#GO:0006096;organic cyclic compound catabolic process#GO:1901361;organophosphate metabolic process#GO:0019637;purine nucleoside triphosphate metabolic process#GO:0009144;nucleobase-containing compound catabolic process#GO:0034655;nucleotide metabolic process#GO:0009117;carboxylic acid metabolic process#GO:0019752;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 lyase#PC00144 Glycolysis#P00024>Enolase#P00678 HELRO|EnsemblGenome=HelroG166153|UniProtKB=T1EXU7 T1EXU7 20201397 PTHR46004:SF3 CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 Transcription regulation by bZIP transcription factor#P00055>CREB#P01383;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CREB#P00713 HELRO|EnsemblGenome=HelroG161898|UniProtKB=T1ES06 T1ES06 20199356 PTHR34209:SF1 RHODANESE/CELL CYCLE CONTROL PHOSPHATASE SUPERFAMILY PROTEIN CALCIUM SENSING RECEPTOR, CHLOROPLASTIC protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG163986|UniProtKB=T1EUQ3 T1EUQ3 20200303 PTHR45775:SF6 RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C HELRO|EnsemblGenome=HelroG167911|UniProtKB=T1EZY0 T1EZY0 20202130 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG91677|UniProtKB=T1G876 T1G876 20217273 PTHR16797:SF4 FACTOR VIII-ASSOCIATED GENE 1 40-KDA HUNTINGTIN-ASSOCIATED PROTEIN localization#GO:0051179;cellular localization#GO:0051641;organelle localization#GO:0051640;vesicle localization#GO:0051648;establishment of localization#GO:0051234;establishment of vesicle localization#GO:0051650;transport#GO:0006810;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular process#GO:0009987;establishment of organelle localization#GO:0051656;vesicle cytoskeletal trafficking#GO:0099518 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG189698|UniProtKB=T1FR98 T1FR98 20211345 PTHR46641:SF25 FMRFAMIDE RECEPTOR-RELATED CNMAMIDE RECEPTOR-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG63763|UniProtKB=T1FXK0 T1FXK0 20213548 PTHR12992:SF11 NUDIX HYDROLASE MITOCHONDRIAL COENZYME A DIPHOSPHATASE NUDT8 hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG192152|UniProtKB=T1FTM9 T1FTM9 20212176 PTHR46169:SF27 DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A SI:DKEY-13N23.3-RELATED regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG64105|UniProtKB=T1FXP2 T1FXP2 20213590 PTHR10024:SF344 SYNAPTOTAGMIN SYNAPTOTAGMIN-7 cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;phosphatidylserine binding#GO:0001786;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;protein binding#GO:0005515;clathrin binding#GO:0030276;lipid binding#GO:0008289;ion binding#GO:0043167;phospholipid binding#GO:0005543;SNARE binding#GO:0000149 vesicle fusion#GO:0006906;cellular localization#GO:0051641;synaptic vesicle cycle#GO:0099504;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;regulated exocytosis#GO:0045055;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;secretion#GO:0046903;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;signal release#GO:0023061;vesicle organization#GO:0016050;calcium-ion regulated exocytosis#GO:0017156;signaling#GO:0023052;cell-cell signaling#GO:0007267;synaptic vesicle exocytosis#GO:0016079;organelle fusion#GO:0048284;secretion by cell#GO:0032940;neurotransmitter secretion#GO:0007269;trans-synaptic signaling#GO:0099537;vesicle-mediated transport#GO:0016192;cell communication#GO:0007154;cellular component organization#GO:0016043;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;membrane fusion#GO:0061025;signal release from synapse#GO:0099643;exocytosis#GO:0006887;organelle organization#GO:0006996;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;export from cell#GO:0140352;vesicle-mediated transport in synapse#GO:0099003 synapse#GO:0045202;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;axon#GO:0030424;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;neuron projection#GO:0043005;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;transport vesicle#GO:0030133;cell projection#GO:0042995;secretory vesicle#GO:0099503;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG182242|UniProtKB=T1FHZ5 T1FHZ5 20208444 PTHR24107:SF2 YNEIN REGULATORY COMPLEX SUBUNIT 5 NLR FAMILY CARD DOMAIN CONTAINING 3 non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG190369|UniProtKB=T1FRX8 T1FRX8 20211575 PTHR24249:SF424 HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG71159|UniProtKB=T1G0H2 T1G0H2 20214570 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG135743|UniProtKB=T1EIA3 T1EIA3 20196303 PTHR10252:SF5 HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED DR1-ASSOCIATED COREPRESSOR sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;core promoter sequence-specific DNA binding#GO:0001046;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG165025|UniProtKB=T1EW58 T1EW58 20200808 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174327|UniProtKB=T1F806 T1F806 20204955 PTHR33244:SF3 INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED PEPTIDASE A2 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG62239|UniProtKB=T1FWX7 T1FWX7 20213325 PTHR10969:SF4 MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 2 lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488 cellular component biogenesis#GO:0044085;macroautophagy#GO:0016236;autophagy of mitochondrion#GO:0000422;response to extracellular stimulus#GO:0009991;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;cellular component disassembly#GO:0022411;cellular response to starvation#GO:0009267;catabolic process#GO:0009056;mitochondrion organization#GO:0007005;autophagosome maturation#GO:0097352;cellular response to extracellular stimulus#GO:0031668;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;cellular component assembly#GO:0022607;cellular response to stimulus#GO:0051716;protein-containing complex disassembly#GO:0032984;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cell communication#GO:0007154;response to nutrient levels#GO:0031667;cellular process#GO:0009987;organelle disassembly#GO:1903008;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to stress#GO:0006950;cellular response to nutrient levels#GO:0031669;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;response to starvation#GO:0042594;cellular response to external stimulus#GO:0071496;autophagosome assembly#GO:0000045;cellular response to stress#GO:0033554;autophagy#GO:0006914 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;autophagosome membrane#GO:0000421;intracellular membrane-bounded organelle#GO:0043231;vacuolar membrane#GO:0005774;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;autophagosome#GO:0005776;intracellular anatomical structure#GO:0005622 non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG152303|UniProtKB=T1EKQ6 T1EKQ6 20197156 PTHR12962:SF1 CALCIUM-REGULATED HEAT STABLE PROTEIN CRHSP-24-RELATED COLD SHOCK DOMAIN-CONTAINING PROTEIN CG9705 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159;mRNA 3'-UTR binding#GO:0003730 regulation of mRNA stability#GO:0043488;regulation of catabolic process#GO:0009894;regulation of mRNA catabolic process#GO:0061013;regulation of nitrogen compound metabolic process#GO:0051171;regulation of cellular catabolic process#GO:0031329;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of biological quality#GO:0065008;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG64110|UniProtKB=T1FXP4 T1FXP4 20213592 PTHR10648:SF4 SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888 macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;dephosphorylation#GO:0016311;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;protein metabolic process#GO:0019538;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 phosphatase modulator#PC00184 FGF signaling pathway#P00021>PP2A#P00629 HELRO|EnsemblGenome=HelroG183800|UniProtKB=T1FK77 T1FK77 20209226 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175149|UniProtKB=T1F8X3 T1F8X3 20205272 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG136534|UniProtKB=T1EIE4 T1EIE4 20196344 PTHR23349:SF68 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST FI14601P sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG172300|UniProtKB=T1F570 T1F570 20203969 PTHR44942:SF4 METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168846|UniProtKB=T1F113 T1F113 20202513 PTHR15683:SF8 SCAFFOLD ATTACHMENT FACTOR B-RELATED SCAFFOLD ATTACHMENT FACTOR B, ISOFORM B sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of mRNA processing#GO:0050684;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;regulation of mRNA metabolic process#GO:1903311 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG189028|UniProtKB=T1FQK6 T1FQK6 20211103 PTHR24230:SF158 G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;neuropeptide signaling pathway#GO:0007218;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG191728|UniProtKB=T1FT85 T1FT85 20212032 PTHR10117:SF54 TRANSIENT RECEPTOR POTENTIAL CHANNEL TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;small molecule binding#GO:0036094;binding#GO:0005488;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;anion binding#GO:0043168;ion binding#GO:0043167;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;alcohol binding#GO:0043178 inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;regulation of cytosolic calcium ion concentration#GO:0051480;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;calcium ion transport#GO:0006816;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 Alzheimer disease-presenilin pathway#P00004>Capacitative calcium channels#P00124 HELRO|EnsemblGenome=HelroG90218|UniProtKB=T1G7M4 T1G7M4 20217071 PTHR23050:SF518 CALCIUM BINDING PROTEIN AT16150P-RELATED cation binding#GO:0043169;small molecule binding#GO:0036094;molecular function regulator activity#GO:0098772;binding#GO:0005488;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;enzyme regulator activity#GO:0030234 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061 B cell activation#P00010>Calmodulin#P00375;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Calmodulin#P00755;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716;T cell activation#P00053>Calmodulin#P01305 HELRO|EnsemblGenome=HelroG68824|UniProtKB=T1FZK2 T1FZK2 20214250 PTHR23105:SF1 RIBOSOMAL PROTEIN L7AE FAMILY MEMBER LARGE RIBOSOMAL SUBUNIT PROTEIN EL8 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of LSU-rRNA#GO:0000470;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG167193|UniProtKB=T1EZ45 T1EZ45 20201845 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176339|UniProtKB=T1FAE6 T1FAE6 20205795 PTHR46186:SF2 CYSTATIN CYSTATIN peptidase inhibitor activity#GO:0030414;molecular function regulator activity#GO:0098772;cysteine-type endopeptidase inhibitor activity#GO:0004869;peptidase regulator activity#GO:0061134;enzyme inhibitor activity#GO:0004857;endopeptidase regulator activity#GO:0061135;endopeptidase inhibitor activity#GO:0004866;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 regulation of proteolysis#GO:0030162;negative regulation of hydrolase activity#GO:0051346;negative regulation of biological process#GO:0048519;regulation of protein metabolic process#GO:0051246;regulation of cysteine-type endopeptidase activity#GO:2000116;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of cysteine-type endopeptidase activity#GO:2000117;negative regulation of peptidase activity#GO:0010466;negative regulation of endopeptidase activity#GO:0010951;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of proteolysis#GO:0045861;regulation of catalytic activity#GO:0050790;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of molecular function#GO:0065009;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336;regulation of endopeptidase activity#GO:0052548;regulation of peptidase activity#GO:0052547;negative regulation of catalytic activity#GO:0043086;regulation of metabolic process#GO:0019222;negative regulation of molecular function#GO:0044092 cytoplasm#GO:0005737;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG64064|UniProtKB=T1FXN9 T1FXN9 20213587 PTHR12883:SF0 ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED PAT COMPLEX SUBUNIT CCDC47 cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG178239|UniProtKB=T1FCZ6 T1FCZ6 20206695 PTHR12064:SF94 METAL TRANSPORTER CNNM UNEXTENDED PROTEIN ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG77677|UniProtKB=T1G322 T1G322 20215470 PTHR10868:SF1 SIGMA 1-TYPE OPIOID RECEPTOR-RELATED SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG190982|UniProtKB=T1FSH0 T1FSH0 20211767 PTHR24044:SF421 NOTCH LIGAND FAMILY MEMBER PROTEIN JAGGED-2 protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 intercellular signal molecule#PC00207 Notch signaling pathway#P00045>Next#P01103;Angiogenesis#P00005>Delta/Serrate#P00226;Notch signaling pathway#P00045>Serrate#P01104 HELRO|EnsemblGenome=HelroG171419|UniProtKB=T1F493 T1F493 20203642 PTHR23359:SF243 NUCLEOTIDE KINASE ADENYLATE KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, phosphate group as acceptor#GO:0016776;catalytic activity#GO:0003824;kinase activity#GO:0016301 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 nucleotide kinase#PC00172;kinase#PC00137 HELRO|EnsemblGenome=HelroG163187|UniProtKB=T1ETS2 T1ETS2 20199972 PTHR13526:SF8 TRANSCRIPTION FACTOR SPT20 HOMOLOG TRANSCRIPTION FACTOR SPT20 HOMOLOG molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 SAGA-type complex#GO:0070461;peptidase complex#GO:1905368;histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;chromosome#GO:0005694;SAGA complex#GO:0000124 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG152344|UniProtKB=T1EKR1 T1EKR1 20197161 PTHR11636:SF84 POU DOMAIN NETRIN-1-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 homeodomain transcription factor#PC00119 Axon guidance mediated by netrin#P00009>Netrin#P00357;Axon guidance mediated by Slit/Robo#P00008>Netrin#P00344 HELRO|EnsemblGenome=HelroG188772|UniProtKB=T1FQC3 T1FQC3 20211020 PTHR10333:SF103 INHIBITOR OF GROWTH PROTEIN INHIBITOR OF GROWTH PROTEIN 3 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG160132|UniProtKB=T1EPU7 T1EPU7 20198597 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG131046|UniProtKB=T1EHV1 T1EHV1 20196151 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;chloride transmembrane transporter activity#GO:0015108;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;inorganic anion transmembrane transport#GO:0098661;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic anion transport#GO:0006820;chloride transport#GO:0006821;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;inorganic anion transport#GO:0015698 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG158501|UniProtKB=T1EMV2 T1EMV2 20197902 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG96235|UniProtKB=T1G9A8 T1G9A8 20217655 PTHR11937:SF526 ACTIN ACTIN, CYTOPLASMIC 1-RELATED intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 actin and actin related protein#PC00039;cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Integrin signalling pathway#P00034>Actin#P00944;Alzheimer disease-presenilin pathway#P00004>actin#P00114;Nicotinic acetylcholine receptor signaling pathway#P00044>Actin#P01090;Huntington disease#P00029>Actin#P00807;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>F-actin#P00858;Cadherin signaling pathway#P00012>F-actin#P00470;Cytoskeletal regulation by Rho GTPase#P00016>Actin#P00512 HELRO|EnsemblGenome=HelroG87495|UniProtKB=T1G6R0 T1G6R0 20216757 PTHR12951:SF1 RETINAL PROTEIN 4 PROTEIN UNC-119 HOMOLOG lipid binding#GO:0008289;binding#GO:0005488 cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;cilium assembly#GO:0060271;cell projection organization#GO:0030030;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;establishment of protein localization#GO:0045184;cell projection assembly#GO:0030031;protein localization#GO:0008104;localization#GO:0051179;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;organelle organization#GO:0006996;protein transport#GO:0015031;plasma membrane bounded cell projection assembly#GO:0120031 membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;organelle#GO:0043226;cilium#GO:0005929;plasma membrane bounded cell projection#GO:0120025 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG67692|UniProtKB=T1FZ40 T1FZ40 20214088 PTHR24353:SF153 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;cytosol#GO:0005829;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Enkephalin release#P05913>PKA#P05972;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Endothelin signaling pathway#P00019>PKA#P00570;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059 HELRO|EnsemblGenome=HelroG180856|UniProtKB=T1FGC2 T1FGC2 20207871 PTHR43170:SF5 GMP REDUCTASE GMP REDUCTASE reductase#PC00198;oxidoreductase#PC00176 De novo purine biosynthesis#P02738>IMP dehydrogenase#P02895 HELRO|EnsemblGenome=HelroG166051|UniProtKB=T1EXM9 T1EXM9 20201329 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG63269|UniProtKB=T1FXD2 T1FXD2 20213480 PTHR10778:SF13 SOLUTE CARRIER FAMILY 35 MEMBER B ADENOSINE 3'-PHOSPHO 5'-PHOSPHOSULFATE TRANSPORTER 1 carbohydrate derivative transmembrane transporter activity#GO:1901505;purine nucleotide transmembrane transporter activity#GO:0015216;nucleobase-containing compound transmembrane transporter activity#GO:0015932;transmembrane transporter activity#GO:0022857;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215 localization#GO:0051179;organic substance transport#GO:0071702;organophosphate ester transport#GO:0015748;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;organic anion transport#GO:0015711;nucleobase-containing compound transport#GO:0015931;transport#GO:0006810;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264 bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;Golgi membrane#GO:0000139;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG156372|UniProtKB=T1ELU7 T1ELU7 20197547 PTHR24073:SF285 DRAB5-RELATED RAS-RELATED PROTEIN RAB-18 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 localization#GO:0051179;organic substance transport#GO:0071702;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;protein transport#GO:0015031;nitrogen compound transport#GO:0071705;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG117142|UniProtKB=T1EGK6 T1EGK6 PTHR24291:SF48 CYTOCHROME P450 FAMILY 4 CYTOCHROME P450 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG62232|UniProtKB=T1FWX4 T1FWX4 20213322 PTHR22168:SF8 TMEM26 PROTEIN TRANSMEMBRANE PROTEIN 26 HELRO|EnsemblGenome=HelroG169072|UniProtKB=T1F1D1 T1F1D1 20202631 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG160665|UniProtKB=T1EQK7 T1EQK7 20198857 PTHR31551:SF1 PRE-MRNA-SPLICING FACTOR CWF18 COILED-COIL DOMAIN-CONTAINING PROTEIN 12 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;U2-type spliceosomal complex#GO:0005684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;post-mRNA release spliceosomal complex#GO:0071014;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG108545|UniProtKB=T1EEK2 T1EEK2 20195004 PTHR10153:SF44 SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;binding#GO:0005488;calmodulin binding#GO:0005516;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic ion-gated channel activity#GO:0022839;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium-activated cation channel activity#GO:0005227;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;protein binding#GO:0005515;monoatomic ion channel activity#GO:0005216;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 somatodendritic compartment#GO:0036477;cell body#GO:0044297;neuron projection#GO:0043005;neuronal cell body#GO:0043025;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG106716|UniProtKB=T1EE41 T1EE41 20194843 PTHR47958:SF56 ATP-DEPENDENT RNA HELICASE DBP3 RNA HELICASE catalytic activity, acting on RNA#GO:0140098;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640;mRNA binding#GO:0003729 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;mRNA splicing, via spliceosome#GO:0000398;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;catalytic step 2 spliceosome#GO:0071013;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG187336|UniProtKB=T1FP89 T1FP89 20210636 PTHR23305:SF11 OBG GTPASE FAMILY OBG-LIKE ATPASE 1 pyrophosphatase activity#GO:0016462;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 G-protein#PC00020;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG68491|UniProtKB=T1FZF5 T1FZF5 20214203 PTHR23354:SF62 NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED MUSTARD, ISOFORM V HELRO|EnsemblGenome=HelroG185271|UniProtKB=T1FML2 T1FML2 20210061 PTHR11802:SF201 SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE CARBOXYPEPTIDASE hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171;carboxypeptidase activity#GO:0004180 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185490|UniProtKB=T1FMW0 T1FMW0 20210159 PTHR11360:SF251 MONOCARBOXYLATE TRANSPORTER MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN transporter#PC00227 HELRO|EnsemblGenome=HelroG175853|UniProtKB=T1F9S2 T1F9S2 20205571 PTHR47160:SF8 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG86903|UniProtKB=T1G6J0 T1G6J0 20216687 PTHR24346:SF82 MAP/MICROTUBULE AFFINITY-REGULATING KINASE KP78A-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG162703|UniProtKB=T1ET10 T1ET10 20199710 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178767|UniProtKB=T1FDP6 T1FDP6 20206945 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG65067|UniProtKB=T1FY27 T1FY27 20213725 PTHR11071:SF561 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;catalytic activity#GO:0003824;peptide binding#GO:0042277;amide binding#GO:0033218 macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein peptidyl-prolyl isomerization#GO:0000413;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG89315|UniProtKB=T1G7C0 T1G7C0 20216967 PTHR10252:SF5 HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED DR1-ASSOCIATED COREPRESSOR sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;core promoter sequence-specific DNA binding#GO:0001046;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG191951|UniProtKB=T1FTG0 T1FTG0 20212107 PTHR11132:SF240 SOLUTE CARRIER FAMILY 35 UDP-SUGAR TRANSPORTER UST74C carbohydrate derivative transmembrane transporter activity#GO:1901505;secondary active transmembrane transporter activity#GO:0015291;antiporter activity#GO:0015297;transmembrane transporter activity#GO:0022857;nucleobase-containing compound transmembrane transporter activity#GO:0015932;nucleotide-sugar transmembrane transporter activity#GO:0005338;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215 localization#GO:0051179;organic substance transport#GO:0071702;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;nucleobase-containing compound transport#GO:0015931;nucleotide-sugar transmembrane transport#GO:0015780;transport#GO:0006810;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG64229|UniProtKB=T1FXR6 T1FXR6 20213614 PTHR14003:SF19 TRANSCRIPTIONAL REPRESSOR PROTEIN YY YY2 TRANSCRIPTION FACTOR sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;PcG protein complex#GO:0031519;protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG168718|UniProtKB=T1F0W1 T1F0W1 20202461 PTHR24126:SF14 ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED ANK_REP_REGION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165209|UniProtKB=T1EWF8 T1EWF8 20200908 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG66726|UniProtKB=T1FYP4 T1FYP4 20213942 PTHR15239:SF6 NUCLEAR EXPORT MEDIATOR FACTOR NEMF RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF tRNA binding#GO:0000049;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159;ribosome binding#GO:0043022;ribonucleoprotein complex binding#GO:0043021;protein-containing complex binding#GO:0044877 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;organelle disassembly#GO:1903008;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;cellular component organization or biogenesis#GO:0071840;peptide biosynthetic process#GO:0043043;cellular component disassembly#GO:0022411;organelle organization#GO:0006996;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;translational elongation#GO:0006414;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG181765|UniProtKB=T1FHA9 T1FHA9 20208208 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG171304|UniProtKB=T1F425 T1F425 20203574 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG181957|UniProtKB=T1FHI5 T1FHI5 20208284 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG84162|UniProtKB=T1G5F7 T1G5F7 20216304 PTHR13344:SF0 NADH-UBIQUINONE OXIDOREDUCTASE NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transporter complex#GO:1990351;oxidoreductase complex#GO:1990204;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;respirasome#GO:0070469;mitochondrial respiratory chain complex I#GO:0005747;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;transmembrane transporter complex#GO:1902495;mitochondrial respirasome#GO:0005746;membrane-bounded organelle#GO:0043227;respiratory chain complex I#GO:0045271;NADH dehydrogenase complex#GO:0030964;mitochondrial protein-containing complex#GO:0098798 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG74056|UniProtKB=T1G1L9 T1G1L9 20214967 PTHR21625:SF0 NYD-SP28 PROTEIN DYNEIN REGULATORY COMPLEX SUBUNIT 2 regulation of microtubule-based process#GO:0032886;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;microtubule cytoskeleton organization#GO:0000226;cilium or flagellum-dependent cell motility#GO:0001539;protein-containing complex assembly#GO:0065003;cell motility#GO:0048870;cellular component organization#GO:0016043;axoneme assembly#GO:0035082;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;regulation of biological process#GO:0050789;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cilium-dependent cell motility#GO:0060285;microtubule-based process#GO:0007017;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection assembly#GO:0120031 axoneme#GO:0005930;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;plasma membrane bounded cell projection cytoplasm#GO:0032838;membrane-bounded organelle#GO:0043227;ciliary plasm#GO:0097014;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG175527|UniProtKB=T1F9C9 T1F9C9 20205428 PTHR10334:SF498 CYSTEINE-RICH SECRETORY PROTEIN-RELATED MIP16674P defense/immunity protein#PC00090 PI3 kinase pathway#P00048>scl-1#G01545 HELRO|EnsemblGenome=HelroG99451|UniProtKB=T1G9S8 T1G9S8 20217824 PTHR48041:SF78 ABC TRANSPORTER G FAMILY MEMBER 28 ABC TRANSPORTER EXPRESSED IN TRACHEA, ISOFORM A transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG166646|UniProtKB=T1EYB4 T1EYB4 20201564 PTHR14312:SF6 CREB/ATF BZIP TRANSCRIPTION FACTOR SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG157588|UniProtKB=T1EMD6 T1EMD6 20197736 PTHR24351:SF110 RIBOSOMAL PROTEIN S6 KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;nitrogen compound metabolic process#GO:0006807;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 Interleukin signaling pathway#P00036>p90RSK#P00964;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>P90 RSK#P00888;PDGF signaling pathway#P00047>p90RSK#P01142 HELRO|EnsemblGenome=HelroG192700|UniProtKB=T1FU76 T1FU76 20212372 PTHR10104:SF1 STATHMIN STATHMIN, ISOFORM D cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 regulation of microtubule-based process#GO:0032886;neurogenesis#GO:0022008;cell projection organization#GO:0030030;microtubule depolymerization#GO:0007019;developmental process#GO:0032502;microtubule cytoskeleton organization#GO:0000226;regulation of cellular component organization#GO:0051128;nervous system development#GO:0007399;microtubule polymerization or depolymerization#GO:0031109;plasma membrane bounded cell projection organization#GO:0120036;regulation of biological process#GO:0050789;system development#GO:0048731;cell differentiation#GO:0030154;regulation of cytoskeleton organization#GO:0051493;cellular component disassembly#GO:0022411;supramolecular fiber organization#GO:0097435;regulation of microtubule cytoskeleton organization#GO:0070507;neuron differentiation#GO:0030182;cytoskeleton organization#GO:0007010;cellular developmental process#GO:0048869;protein-containing complex disassembly#GO:0032984;regulation of organelle organization#GO:0033043;multicellular organism development#GO:0007275;cellular component organization#GO:0016043;protein depolymerization#GO:0051261;regulation of microtubule polymerization or depolymerization#GO:0031110;cellular process#GO:0009987;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;microtubule-based process#GO:0007017;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;protein-containing complex organization#GO:0043933;anatomical structure development#GO:0048856;biological regulation#GO:0065007;neuron development#GO:0048666;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 cytoplasm#GO:0005737;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;neuron projection#GO:0043005;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG121380|UniProtKB=T1EGR7 T1EGR7 20195767 PTHR11675:SF119 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2 transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG102106|UniProtKB=T1ED80 T1ED80 20194532 PTHR24096:SF149 LONG-CHAIN-FATTY-ACID--COA LIGASE AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED ligase activity#GO:0016874;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 metabolite interconversion enzyme#PC00262;ligase#PC00142 HELRO|EnsemblGenome=HelroG177200|UniProtKB=T1FBC3 T1FBC3 20206122 PTHR23050:SF23 CALCIUM BINDING PROTEIN AT22559P-RELATED cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule-based process#GO:0007017;organelle organization#GO:0006996 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;centriole#GO:0005814;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG186261|UniProtKB=T1FNV9 T1FNV9 20210506 PTHR43170:SF5 GMP REDUCTASE GMP REDUCTASE reductase#PC00198;oxidoreductase#PC00176 De novo purine biosynthesis#P02738>IMP dehydrogenase#P02895 HELRO|EnsemblGenome=HelroG69241|UniProtKB=T1FZR6 T1FZR6 20214314 PTHR24543:SF334 MULTICOPPER OXIDASE-RELATED F5_8 TYPE C DOMAIN-CONTAINING PROTEIN oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG191525|UniProtKB=T1FT22 T1FT22 20211969 PTHR12552:SF1 OLIGOPHRENIN 1 RHO GTPASE-ACTIVATING PROTEIN GRAF nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;GTPase regulator activity#GO:0030695;molecular function activator activity#GO:0140677;GTPase activator activity#GO:0005096;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 PDGF signaling pathway#P00047>Rho#P01174 HELRO|EnsemblGenome=HelroG190950|UniProtKB=T1FSG3 T1FSG3 20211760 PTHR15913:SF0 ACID CLUSTER PROTEIN 33 MASPARDIN HELRO|EnsemblGenome=HelroG157200|UniProtKB=T1EM80 T1EM80 20197680 PTHR10283:SF82 SOLUTE CARRIER FAMILY 13 MEMBER SOLUTE CARRIER FAMILY 13 MEMBER 2 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG188202|UniProtKB=T1FPR9 T1FPR9 20210816 PTHR31431:SF1 NUCLEOPORIN NUP188 HOMOLOG NUCLEOPORIN NUP188 structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056 cellular localization#GO:0051641;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;transport#GO:0006810;protein localization to nucleus#GO:0034504;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of protein localization#GO:0045184;RNA localization#GO:0006403;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;protein import into nucleus#GO:0006606;cellular macromolecule localization#GO:0070727;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169;import into nucleus#GO:0051170 envelope#GO:0031975;nuclear pore#GO:0005643;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG91895|UniProtKB=T1G8A3 T1G8A3 20217300 PTHR10634:SF149 AN1-TYPE ZINC FINGER PROTEIN AN1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG113708|UniProtKB=T1EFV5 T1EFV5 20195457 PTHR22957:SF681 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN SMALL G PROTEIN SIGNALING MODULATOR 3 nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;activation of GTPase activity#GO:0090630;biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG176357|UniProtKB=T1FAF8 T1FAF8 20205807 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG181554|UniProtKB=T1FH36 T1FH36 20208135 PTHR11311:SF30 SPONDIN SPONDIN-LIKE TSP1 DOMAIN-CONTAINING PROTEIN cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;organelle organization#GO:0006996 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG153934|UniProtKB=T1ELD1 T1ELD1 20197381 PTHR18860:SF17 14-3-3 PROTEIN 14-3-3 PROTEIN EPSILON localization#GO:0051179;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular localization#GO:0051641;cellular response to stimulus#GO:0051716;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052;protein localization#GO:0008104 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 Parkinson disease#P00049>14-3-3#P01238;FGF signaling pathway#P00021>14-3-3#P00624;EGF receptor signaling pathway#P00018>14-3-3#P00539 HELRO|EnsemblGenome=HelroG137091|UniProtKB=T1EIH4 T1EIH4 20196375 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED single-stranded RNA binding#GO:0003727;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;poly(A) binding#GO:0008143;binding#GO:0005488;organic cyclic compound binding#GO:0097159 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG175388|UniProtKB=T1F981 T1F981 20205380 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158094|UniProtKB=T1EMJ4 T1EMJ4 20197794 PTHR13822:SF7 ATP SYNTHASE DELTA/EPSILON CHAIN ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL monoatomic cation channel activity#GO:0005261;ligase activity#GO:0016874;inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;catalytic activity#GO:0003824;proton transmembrane transporter activity#GO:0015078;proton channel activity#GO:0015252;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;inorganic cation transmembrane transporter activity#GO:0022890;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 cellular aromatic compound metabolic process#GO:0006725;ribonucleoside triphosphate metabolic process#GO:0009199;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative metabolic process#GO:1901135;ATP biosynthetic process#GO:0006754;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;purine nucleoside triphosphate biosynthetic process#GO:0009145;heterocycle metabolic process#GO:0046483;purine ribonucleoside triphosphate metabolic process#GO:0009205;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;ribonucleoside triphosphate biosynthetic process#GO:0009201;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;proton motive force-driven ATP synthesis#GO:0015986;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;purine nucleoside triphosphate metabolic process#GO:0009144;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;ATPase complex#GO:1904949;organelle inner membrane#GO:0019866;mitochondrial proton-transporting ATP synthase complex#GO:0005753;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;proton-transporting two-sector ATPase complex#GO:0016469;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;proton-transporting ATP synthase complex#GO:0045259;mitochondrial protein-containing complex#GO:0098798 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG111970|UniProtKB=T1EFG1 T1EFG1 20195313 PTHR24012:SF796 RNA BINDING PROTEIN PROTEIN ALAN SHEPARD nucleic acid binding#GO:0003676;single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159;mRNA binding#GO:0003729;poly(A) binding#GO:0008143;mRNA 3'-UTR binding#GO:0003730 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG188599|UniProtKB=T1FQ59 T1FQ59 20210956 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG183202|UniProtKB=T1FJA7 T1FJA7 20208906 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG188354|UniProtKB=T1FPW9 T1FPW9 20210866 PTHR24104:SF48 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED PROTEIN WECH transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG84941|UniProtKB=T1G5Q7 T1G5Q7 20216404 PTHR14167:SF81 SH3 DOMAIN-CONTAINING ENDOPHILIN-A scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG108234|UniProtKB=T1EEH4 T1EEH4 20194976 PTHR13389:SF0 PUMILIO HOMOLOG 3 PUMILIO HOMOLOG 3 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG157043|UniProtKB=T1EM54 T1EM54 20197654 PTHR11875:SF49 TESTIS-SPECIFIC Y-ENCODED PROTEIN PROTEIN SET protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;chromatin binding#GO:0003682;histone binding#GO:0042393 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;chromosome#GO:0005694;chromatin#GO:0000785;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG131625|UniProtKB=T1EHW2 T1EHW2 20196162 PTHR48012:SF2 STERILE20-LIKE KINASE, ISOFORM B-RELATED STERILE20-LIKE KINASE, ISOFORM B transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG189201|UniProtKB=T1FQS2 T1FQS2 20211169 PTHR10082:SF60 INTEGRIN BETA SUBUNIT INTEGRIN BETA-PS cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;integrin binding#GO:0005178;binding#GO:0005488;signaling receptor binding#GO:0005102 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;cell adhesion mediated by integrin#GO:0033627;cell-cell adhesion#GO:0098609;cell motility#GO:0048870;cell adhesion#GO:0007155;cell communication#GO:0007154;cell-substrate adhesion#GO:0031589;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cell-matrix adhesion#GO:0007160;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;integrin-mediated signaling pathway#GO:0007229;cell migration#GO:0016477;signaling#GO:0023052 receptor complex#GO:0043235;membrane protein complex#GO:0098796;cell surface#GO:0009986;protein-containing complex#GO:0032991;plasma membrane signaling receptor complex#GO:0098802;anchoring junction#GO:0070161;plasma membrane protein complex#GO:0098797;focal adhesion#GO:0005925;cell junction#GO:0030054;cell-substrate junction#GO:0030055;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;integrin#PC00126 Integrin signalling pathway#P00034>Integrin beta#P00931 HELRO|EnsemblGenome=HelroG177712|UniProtKB=T1FC44 T1FC44 20206393 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG157123|UniProtKB=T1EM65 T1EM65 20197665 PTHR10454:SF210 CASPASE CASPASE-2 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG177448|UniProtKB=T1FBQ3 T1FBQ3 20206252 PTHR33332:SF48 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166174|UniProtKB=T1EXV3 T1EXV3 20201403 PTHR19423:SF1 SH3 DOMAIN-BINDING PROTEIN 5 SH3 DOMAIN-BINDING PROTEIN 5 enzyme inhibitor activity#GO:0004857;protein kinase regulator activity#GO:0019887;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase inhibitor activity#GO:0004860 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194177|UniProtKB=T1FVS2 T1FVS2 20212918 PTHR45614:SF25 MYB PROTEIN-RELATED MYB PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG98804|UniProtKB=T1G9P9 T1G9P9 20217795 PTHR22807:SF30 NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING 28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;methylation#GO:0032259;macromolecule methylation#GO:0043414;nitrogen compound metabolic process#GO:0006807;RNA methylation#GO:0001510;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG186294|UniProtKB=T1FNX9 T1FNX9 20210526 PTHR43599:SF3 MULTIFUNCTIONAL PROTEIN ADE2 SI:DKEY-6E2.2 HELRO|EnsemblGenome=HelroG158419|UniProtKB=T1EMR7 T1EMR7 20197867 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG89090|UniProtKB=T1G784 T1G784 20216931 PTHR45981:SF3 LD02310P LD02310P transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG186472|UniProtKB=T1FNZ9 T1FNZ9 20210546 PTHR18860:SF159 14-3-3 PROTEIN 14-3-3 PROTEIN ZETA localization#GO:0051179;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular localization#GO:0051641;cellular response to stimulus#GO:0051716;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052;protein localization#GO:0008104 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 Parkinson disease#P00049>14-3-3#P01238;FGF signaling pathway#P00021>14-3-3#P00624;EGF receptor signaling pathway#P00018>14-3-3#P00539;PI3 kinase pathway#P00048>14-3-3#P01206 HELRO|EnsemblGenome=HelroG106819|UniProtKB=T1EE52 T1EE52 20194854 PTHR11814:SF55 SULFATE TRANSPORTER SODIUM-INDEPENDENT SULFATE ANION TRANSPORTER cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG190510|UniProtKB=T1FS22 T1FS22 20211619 PTHR11188:SF176 ARRESTIN DOMAIN CONTAINING PROTEIN ARRESTIN DOMAIN-CONTAINING PROTEIN 1 localization#GO:0051179;organic substance transport#GO:0071702;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;protein transport#GO:0015031;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG177097|UniProtKB=T1FB81 T1FB81 20206080 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG134076|UniProtKB=T1EI32 T1EI32 20196232 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG177647|UniProtKB=T1FC03 T1FC03 20206352 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG187346|UniProtKB=T1FP90 T1FP90 20210637 PTHR21017:SF17 NIPSNAP-RELATED PROTEIN NIPSNAP HELRO|EnsemblGenome=HelroG186205|UniProtKB=T1FNT3 T1FNT3 20210480 PTHR13439:SF0 CT120 PROTEIN TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4 lipid homeostasis#GO:0055088;homeostatic process#GO:0042592;chemical homeostasis#GO:0048878 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG102915|UniProtKB=T1EDD0 T1EDD0 20194582 PTHR17039:SF0 U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10 U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10 membrane-enclosed lumen#GO:0031974;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513;90S preribosome#GO:0030686 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG181249|UniProtKB=T1FGS7 T1FGS7 20208026 PTHR34718:SF2 PHD-TYPE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193988|UniProtKB=T1FVJ7 T1FVJ7 20212843 PTHR31516:SF17 STABILIZER OF AXONEMAL MICROTUBULES 2 STABILIZER OF AXONEMAL MICROTUBULES 2 cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;microtubule binding#GO:0008017;tubulin binding#GO:0015631;binding#GO:0005488 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG188532|UniProtKB=T1FQ36 T1FQ36 20210933 PTHR21497:SF24 UBIQUITIN LIGASE E3 ALPHA-RELATED E3 UBIQUITIN-PROTEIN LIGASE UBR1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG194166|UniProtKB=T1FVR8 T1FVR8 20212914 PTHR23320:SF165 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MARVEL DOMAIN-CONTAINING PROTEIN transporter#PC00227 HELRO|EnsemblGenome=HelroG181763|UniProtKB=T1FHA8 T1FHA8 20208207 PTHR12460:SF0 CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN CID DOMAIN-CONTAINING PROTEIN-RELATED basal RNA polymerase II transcription machinery binding#GO:0001099;RNA polymerase binding#GO:0070063;binding#GO:0005488;RNA polymerase core enzyme binding#GO:0043175;RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515;enzyme binding#GO:0019899;basal transcription machinery binding#GO:0001098 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;mRNA 3'-end processing#GO:0031124;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mRNA processing#GO:0006397;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 kinase modulator#PC00140;kinase inhibitor#PC00139 HELRO|EnsemblGenome=HelroG174892|UniProtKB=T1F8L0 T1F8L0 20205159 PTHR45834:SF3 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9-RELATED RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 3, ISOFORM L nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG87042|UniProtKB=T1G6K9 T1G6K9 20216706 PTHR10454:SF210 CASPASE CASPASE-2 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG193946|UniProtKB=T1FVI3 T1FVI3 20212829 PTHR10120:SF24 CAAX PRENYL PROTEASE 1 CAAX PRENYL PROTEASE 1 HOMOLOG hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG190127|UniProtKB=T1FRP9 T1FRP9 20211496 PTHR12587:SF20 LAR INTERACTING PROTEIN LIP -RELATED PROTEIN LIPRIN-ALPHA, ISOFORM E cellular component organization or biogenesis#GO:0071840;synapse organization#GO:0050808;cellular component organization#GO:0016043;cellular process#GO:0009987;cell junction organization#GO:0034330 cell junction#GO:0030054;presynapse#GO:0098793;synapse#GO:0045202;cellular anatomical entity#GO:0110165;presynaptic active zone#GO:0048786 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG171761|UniProtKB=T1F4M1 T1F4M1 20203770 PTHR12141:SF5 ARFAPTIN-RELATED ARFAPTIN lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488 cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;trans-Golgi network membrane#GO:0032588;organelle subcompartment#GO:0031984;Golgi apparatus subcompartment#GO:0098791;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG111907|UniProtKB=T1EFF7 T1EFF7 20195309 PTHR33562:SF2 ATILLA, ISOFORM B-RELATED-RELATED PROTEIN QUIVER HELRO|EnsemblGenome=HelroG72466|UniProtKB=T1G105 T1G105 20214753 PTHR45721:SF12 LAMIN DM0-RELATED INTERMEDIATE FILAMENT PROTEIN IFA-1 structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;nuclear migration#GO:0007097;cellular localization#GO:0051641;negative regulation of biological process#GO:0048519;protein-DNA complex organization#GO:0071824;organelle localization#GO:0051640;macromolecule localization#GO:0033036;membrane organization#GO:0061024;transport#GO:0006810;protein localization to nucleus#GO:0034504;nucleus organization#GO:0006997;endomembrane system organization#GO:0010256;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;protein localization to organelle#GO:0033365;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;establishment of organelle localization#GO:0051656;negative regulation of cellular process#GO:0048523;localization within membrane#GO:0051668;negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;cellular process#GO:0009987;negative regulation of gene expression, epigenetic#GO:0045814;epigenetic regulation of gene expression#GO:0040029;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular macromolecule localization#GO:0070727;heterochromatin organization#GO:0070828;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;chromatin organization#GO:0006325;intracellular transport#GO:0046907;nuclear envelope organization#GO:0006998;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323;protein-containing complex localization#GO:0031503 membrane-enclosed lumen#GO:0031974;envelope#GO:0031975;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;nuclear periphery#GO:0034399;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981 HELRO|EnsemblGenome=HelroG160208|UniProtKB=T1EPZ3 T1EPZ3 20198643 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG190854|UniProtKB=T1FSD2 T1FSD2 20211729 PTHR35836:SF1 VCBS REPEAT-CONTAINING PROTEIN VCBS REPEAT-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191787|UniProtKB=T1FTB7 T1FTB7 20212064 PTHR11412:SF136 MACROGLOBULIN / COMPLEMENT CD109 ANTIGEN protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG158244|UniProtKB=T1EML1 T1EML1 20197811 PTHR22602:SF0 TRANSFERASE CAF17, MITOCHONDRIAL-RELATED TRANSFERASE CAF17, MITOCHONDRIAL-RELATED cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;iron-sulfur cluster assembly#GO:0016226;cellular process#GO:0009987 HELRO|EnsemblGenome=HelroG102759|UniProtKB=T1EDB4 T1EDB4 20194566 PTHR14152:SF5 SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;mRNA cis splicing, via spliceosome#GO:0045292;ncRNA metabolic process#GO:0034660;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;ribosome biogenesis#GO:0042254;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;rRNA metabolic process#GO:0016072;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375 ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;spliceosomal tri-snRNP complex#GO:0097526;U4/U6 x U5 tri-snRNP complex#GO:0046540;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG63831|UniProtKB=T1FXL0 T1FXL0 20213558 PTHR14593:SF5 WD REPEAT-CONTAINING PROTEIN 11 WD REPEAT-CONTAINING PROTEIN 11 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG67417|UniProtKB=T1FZ05 T1FZ05 20214053 PTHR24083:SF104 NUCLEAR HORMONE RECEPTOR TRANSCRIPTION FACTOR HNF-4 HOMOLOG cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;signaling receptor activity#GO:0038023;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG185694|UniProtKB=T1FN57 T1FN57 20210255 PTHR10263:SF5 V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT V-TYPE PROTON ATPASE 16 KDA PROTEOLIPID SUBUNIT C cellular anatomical entity#GO:0110165;membrane#GO:0016020 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG182182|UniProtKB=T1FHW0 T1FHW0 20208409 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185832|UniProtKB=T1FNC6 T1FNC6 20210323 PTHR43570:SF16 ALDEHYDE DEHYDROGENASE ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HELRO|EnsemblGenome=HelroG162956|UniProtKB=T1ETF2 T1ETF2 20199852 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176727|UniProtKB=T1FAU4 T1FAU4 20205943 PTHR15741:SF27 BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR AP-4 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG106726|UniProtKB=T1EE43 T1EE43 20194845 PTHR43580:SF2 OXIDOREDUCTASE GLYR1-RELATED CYTOKINE-LIKE NUCLEAR FACTOR N-PAC oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG192431|UniProtKB=T1FTY5 T1FTY5 20212282 PTHR10983:SF2 1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED ACYL-COA:LYSOPHOSPHATIDYLGLYCEROL ACYLTRANSFERASE 1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;glycerolipid metabolic process#GO:0046486;cellular metabolic process#GO:0044237;phosphatidylinositol metabolic process#GO:0046488;organophosphate metabolic process#GO:0019637;glycerophospholipid metabolic process#GO:0006650;cellular process#GO:0009987;phospholipid metabolic process#GO:0006644;cellular lipid metabolic process#GO:0044255;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG85143|UniProtKB=T1G5T3 T1G5T3 20216430 PTHR11977:SF130 VILLIN SEVERIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;actin polymerization or depolymerization#GO:0008154;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG191938|UniProtKB=T1FTF3 T1FTF3 20212100 PTHR12756:SF12 CYTOSOLIC CARBOXYPEPTIDASE CYTOSOLIC CARBOXYPEPTIDASE-LIKE PROTEIN 5 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG193799|UniProtKB=T1FVD2 T1FVD2 20212778 PTHR12693:SF3 MENIN MENIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;protein-containing complex binding#GO:0044877 negative regulation of biological process#GO:0048519;regulation of cell population proliferation#GO:0042127;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of cell cycle#GO:0045786;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;negative regulation of cell population proliferation#GO:0008285;regulation of cell cycle#GO:0051726;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;histone methyltransferase complex#GO:0035097;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;methyltransferase complex#GO:0034708;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 CCKR signaling map#P06959>MEN1#P07084 HELRO|EnsemblGenome=HelroG159975|UniProtKB=T1EPM0 T1EPM0 20198520 PTHR10656:SF42 CELL FATE DETERMINING PROTEIN MAB21-RELATED CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED transferase#PC00220;nucleotidyltransferase#PC00174;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG113251|UniProtKB=T1EFR0 T1EFR0 20195412 PTHR12039:SF0 NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 cellular aromatic compound metabolic process#GO:0006725;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;pyridine nucleotide metabolic process#GO:0019362;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;nucleotide biosynthetic process#GO:0009165;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;nicotinamide nucleotide metabolic process#GO:0046496;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 nucleotidyltransferase#PC00174 HELRO|EnsemblGenome=HelroG94060|UniProtKB=T1G8Y8 T1G8Y8 20217535 PTHR11537:SF254 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG146034|UniProtKB=T1EJP6 T1EJP6 20196796 PTHR33332:SF40 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190007|UniProtKB=T1FRL1 T1FRL1 20211458 PTHR14312:SF1 CREB/ATF BZIP TRANSCRIPTION FACTOR BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR A sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG121368|UniProtKB=T1EGR6 T1EGR6 20195766 PTHR24248:SF185 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR DOPAMINE RECEPTOR 2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;regulation of cell communication#GO:0010646;cellular response to stimulus#GO:0051716;regulation of MAPK cascade#GO:0043408;signal transduction#GO:0007165;positive regulation of signal transduction#GO:0009967;regulation of signaling#GO:0023051;cell communication#GO:0007154;cellular process#GO:0009987;regulation of intracellular signal transduction#GO:1902531;positive regulation of MAPK cascade#GO:0043410;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;positive regulation of response to stimulus#GO:0048584;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;positive regulation of cell communication#GO:0010647;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HELRO|EnsemblGenome=HelroG166454|UniProtKB=T1EY54 T1EY54 20201504 PTHR47246:SF1 MUCIN-19 MUCIN-19 HELRO|EnsemblGenome=HelroG188198|UniProtKB=T1FPR7 T1FPR7 20210814 PTHR43807:SF20 FI04487P FI04487P transaminase activity#GO:0008483;transferase activity#GO:0016740;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 transaminase#PC00216;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG190260|UniProtKB=T1FRT9 T1FRT9 20211536 PTHR25462:SF305 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG112849|UniProtKB=T1EFM6 T1EFM6 20195378 PTHR47958:SF104 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE WM6 catalytic activity, acting on RNA#GO:0140098;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640;mRNA binding#GO:0003729 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG179839|UniProtKB=T1FF72 T1FF72 20207471 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG164538|UniProtKB=T1EVK0 T1EVK0 20200600 PTHR14949:SF54 EGF-LIKE-DOMAIN, MULTIPLE 7, 8 VWFD DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 anatomical structure development#GO:0048856;developmental process#GO:0032502 cell surface#GO:0009986;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG162883|UniProtKB=T1ETB4 T1ETB4 20199814 PTHR33332:SF49 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE, PUTATIVE-RELATED HELRO|EnsemblGenome=HelroG88238|UniProtKB=T1G704 T1G704 20216851 PTHR12442:SF7 DYNEIN INTERMEDIATE CHAIN DYNEIN AXONEMAL INTERMEDIATE CHAIN 2 protein binding#GO:0005515;binding#GO:0005488 cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;outer dynein arm assembly#GO:0036158;cell projection organization#GO:0030030;microtubule cytoskeleton organization#GO:0000226;microtubule-based movement#GO:0007018;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;axoneme assembly#GO:0035082;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;cilium movement#GO:0003341;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection assembly#GO:0120031 axoneme#GO:0005930;outer dynein arm#GO:0036157;catalytic complex#GO:1902494;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;microtubule associated complex#GO:0005875;axonemal dynein complex#GO:0005858;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;ciliary plasm#GO:0097014;plasma membrane bounded cell projection cytoplasm#GO:0032838;membrane-bounded organelle#GO:0043227;dynein complex#GO:0030286;cell projection#GO:0042995;cytoskeleton#GO:0005856;cilium#GO:0005929 microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Dynein complex#P00774 HELRO|EnsemblGenome=HelroG161669|UniProtKB=T1ERR7 T1ERR7 20199267 PTHR23103:SF15 ALZHEIMER'S DISEASE BETA-AMYLOID RELATED AMYLOID-BETA-LIKE PROTEIN protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG94735|UniProtKB=T1G927 T1G927 20217574 PTHR11040:SF140 ZINC/IRON TRANSPORTER ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;transition metal ion transport#GO:0000041;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG191256|UniProtKB=T1FST2 T1FST2 20211879 PTHR12693:SF3 MENIN MENIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;protein-containing complex binding#GO:0044877 negative regulation of biological process#GO:0048519;regulation of cell population proliferation#GO:0042127;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of cell cycle#GO:0045786;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;negative regulation of cell population proliferation#GO:0008285;regulation of cell cycle#GO:0051726;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;histone methyltransferase complex#GO:0035097;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;methyltransferase complex#GO:0034708;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 CCKR signaling map#P06959>MEN1#P07084 HELRO|EnsemblGenome=HelroG163051|UniProtKB=T1ETL8 T1ETL8 20199918 PTHR12289:SF41 METAXIN RELATED FAILED AXON CONNECTIONS-RELATED transporter#PC00227 HELRO|EnsemblGenome=HelroG62964|UniProtKB=T1FX87 T1FX87 20213435 PTHR16160:SF13 FERMITIN 2-RELATED FERMITIN 2-RELATED cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;integrin binding#GO:0005178;binding#GO:0005488;signaling receptor binding#GO:0005102 cell adhesion#GO:0007155;cellular process#GO:0009987;cell-matrix adhesion#GO:0007160;cell-substrate adhesion#GO:0031589 cell junction#GO:0030054;cell-substrate junction#GO:0030055;cellular anatomical entity#GO:0110165;anchoring junction#GO:0070161 HELRO|EnsemblGenome=HelroG186091|UniProtKB=T1FNN3 T1FNN3 20210430 PTHR23316:SF28 IMPORTIN ALPHA IMPORTIN SUBUNIT ALPHA signal sequence binding#GO:0005048;binding#GO:0005488;amide binding#GO:0033218;peptide binding#GO:0042277 cellular localization#GO:0051641;NLS-bearing protein import into nucleus#GO:0006607;macromolecule localization#GO:0033036;transport#GO:0006810;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;protein import into nucleus#GO:0006606;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365;nuclear transport#GO:0051169;import into nucleus#GO:0051170 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG180714|UniProtKB=T1FG72 T1FG72 20207821 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77178|UniProtKB=T1G2U1 T1G2U1 20215389 PTHR14256:SF3 NADH-UBIQUINONE OXIDOREDUCTASE MLRQ SUBUNIT NORMAL MUCOSA OF ESOPHAGUS-SPECIFIC GENE 1 PROTEIN envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803;cytochrome complex#GO:0070069;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;respirasome#GO:0070469;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;mitochondrial respirasome#GO:0005746;membrane-bounded organelle#GO:0043227;respiratory chain complex IV#GO:0045277;mitochondrial protein-containing complex#GO:0098798 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG94372|UniProtKB=T1G906 T1G906 20217553 PTHR13586:SF0 SCD6 PROTEIN-RELATED TRAILER HITCH, ISOFORM H nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;non-membrane-bounded organelle assembly#GO:0140694;P-body assembly#GO:0033962;cellular process#GO:0009987 supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;P-body#GO:0000932;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic ribonucleoprotein granule#GO:0036464 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG97598|UniProtKB=T1G9H9 T1G9H9 20217726 PTHR13114:SF7 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17 molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;core mediator complex#GO:0070847;RNA polymerase II transcription regulator complex#GO:0090575;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG105915|UniProtKB=T1EDY7 T1EDY7 20194789 PTHR20338:SF8 NUCLEAR RESPIRATORY FACTOR 1 NUCLEAR RESPIRATORY FACTOR 1 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG144672|UniProtKB=T1EJF8 T1EJF8 20196708 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG194024|UniProtKB=T1FVK9 T1FVK9 20212855 PTHR10643:SF2 KINETOCHORE PROTEIN NDC80 KINETOCHORE PROTEIN NDC80 HOMOLOG nuclear chromosome segregation#GO:0098813;cellular localization#GO:0051641;organelle localization#GO:0051640;establishment of chromosome localization#GO:0051303;sister chromatid segregation#GO:0000819;nuclear division#GO:0000280;attachment of mitotic spindle microtubules to kinetochore#GO:0051315;cell cycle process#GO:0022402;cellular component organization#GO:0016043;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047;chromosome segregation#GO:0007059;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;mitotic metaphase chromosome alignment#GO:0007080;establishment of localization#GO:0051234;organelle organization#GO:0006996;chromosome organization#GO:0051276;cell cycle#GO:0007049;mitotic nuclear division#GO:0140014;organelle fission#GO:0048285;establishment of localization in cell#GO:0051649;attachment of spindle microtubules to kinetochore#GO:0008608;mitotic sister chromatid segregation#GO:0000070;chromosome localization#GO:0050000;establishment of organelle localization#GO:0051656;metaphase chromosome alignment#GO:0051310 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;non-membrane-bounded organelle#GO:0043228;outer kinetochore#GO:0000940;protein-containing complex#GO:0032991;kinetochore#GO:0000776;chromosome#GO:0005694;condensed chromosome, centromeric region#GO:0000779;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;chromosomal region#GO:0098687;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG194929|UniProtKB=T1FWK9 T1FWK9 20213204 PTHR16188:SF14 PROTEIN PHOSPHATASE 1 INHIBITOR POTENTIATED BY PROTEIN KINASE C GEO07393P1 phosphatase regulator activity#GO:0019208;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888;phosphatase inhibitor activity#GO:0019212;enzyme inhibitor activity#GO:0004857;protein phosphatase inhibitor activity#GO:0004864;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;protein serine/threonine phosphatase inhibitor activity#GO:0004865 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG189853|UniProtKB=T1FRF3 T1FRF3 20211400 PTHR13220:SF11 TIMELESS INTERACTING-RELATED TIMELESS-INTERACTING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 cellular aromatic compound metabolic process#GO:0006725;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;signal transduction#GO:0007165;regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA metabolic process#GO:0051052;negative regulation of cell cycle process#GO:0010948;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;cell cycle checkpoint signaling#GO:0000075;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;DNA-templated DNA replication#GO:0006261;intracellular signal transduction#GO:0035556;negative regulation of DNA metabolic process#GO:0051053;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;negative regulation of cell cycle#GO:0045786;regulation of cell cycle phase transition#GO:1901987;negative regulation of cell cycle phase transition#GO:1901988;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;cell communication#GO:0007154;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;negative regulation of nitrogen compound metabolic process#GO:0051172;primary metabolic process#GO:0044238;regulation of cell cycle process#GO:0010564;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;DNA integrity checkpoint signaling#GO:0031570;nucleic acid metabolic process#GO:0090304;regulation of macromolecule metabolic process#GO:0060255;DNA replication checkpoint signaling#GO:0000076;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;DNA replication#GO:0006260;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;nuclear replication fork#GO:0043596;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513;replication fork#GO:0005657 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG187047|UniProtKB=T1FP62 T1FP62 20210609 PTHR43294:SF13 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium ion transmembrane transporter activity#GO:0015079;sodium ion transmembrane transporter activity#GO:0015081;P-type ion transporter activity#GO:0015662;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075 inorganic ion homeostasis#GO:0098771;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;proton transmembrane transport#GO:1902600;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;sodium ion homeostasis#GO:0055078;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;import into cell#GO:0098657;monoatomic cation transmembrane transport#GO:0098655;export from cell#GO:0140352;sodium ion transmembrane transport#GO:0035725;potassium ion import across plasma membrane#GO:1990573;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG89237|UniProtKB=T1G7A7 T1G7A7 20216954 PTHR21614:SF0 SHORT COILED COIL PROTEIN GEO08385P1 cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi apparatus subcompartment#GO:0098791;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG178617|UniProtKB=T1FDG6 T1FDG6 20206865 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183463|UniProtKB=T1FJQ1 T1FJQ1 20209050 PTHR24241:SF76 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR NEUROPEPTIDE SIFAMIDE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;binding#GO:0005488;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888;amide binding#GO:0033218 response to organic substance#GO:0010033;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;response to hormone#GO:0009725;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG185295|UniProtKB=T1FMM5 T1FMM5 20210074 PTHR11521:SF1 TROPONIN T TROPONIN T, SKELETAL MUSCLE cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;binding#GO:0005488 cellular component biogenesis#GO:0044085;muscle cell differentiation#GO:0042692;system process#GO:0003008;developmental process#GO:0032502;myofibril assembly#GO:0030239;cellular anatomical entity morphogenesis#GO:0032989;muscle structure development#GO:0061061;striated muscle cell differentiation#GO:0051146;cell differentiation#GO:0030154;actin filament-based process#GO:0030029;anatomical structure morphogenesis#GO:0009653;supramolecular fiber organization#GO:0097435;striated muscle cell development#GO:0055002;cytoskeleton organization#GO:0007010;non-membrane-bounded organelle assembly#GO:0140694;sarcomere organization#GO:0045214;cellular developmental process#GO:0048869;cellular component assembly#GO:0022607;cellular component assembly involved in morphogenesis#GO:0010927;cellular component organization#GO:0016043;actomyosin structure organization#GO:0031032;cellular process#GO:0009987;anatomical structure formation involved in morphogenesis#GO:0048646;organelle assembly#GO:0070925;cell development#GO:0048468;muscle cell development#GO:0055001;cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;anatomical structure development#GO:0048856;multicellular organismal process#GO:0032501;actin cytoskeleton organization#GO:0030036;muscle system process#GO:0003012;muscle contraction#GO:0006936 supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;organelle#GO:0043226;contractile fiber#GO:0043292;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;sarcomere#GO:0030017;cytoskeleton#GO:0005856;myofibril#GO:0030016 cytoskeletal protein#PC00085;actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG173320|UniProtKB=T1F6P0 T1F6P0 20204489 PTHR23107:SF32 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN CHROMOSOME UNDETERMINED SCAFFOLD_8, WHOLE GENOME SHOTGUN SEQUENCE gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG173420|UniProtKB=T1F6S9 T1F6S9 20204528 PTHR43601:SF3 THIOREDOXIN, MITOCHONDRIAL THIOREDOXIN, MITOCHONDRIAL homeostatic process#GO:0042592;cellular homeostasis#GO:0019725 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 Hypoxia response via HIF activation#P00030>Thioredoxin#P00825 HELRO|EnsemblGenome=HelroG177827|UniProtKB=T1FCC0 T1FCC0 20206469 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163464|UniProtKB=T1EU32 T1EU32 20200082 PTHR12373:SF0 ENHANCER OF RUDIMENTARY ERH ENHANCER OF RUDIMENTARY HOMOLOG DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HELRO|EnsemblGenome=HelroG186224|UniProtKB=T1FNU2 T1FNU2 20210489 PTHR24056:SF508 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 10 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;regulation of mitotic cell cycle#GO:0007346;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG158819|UniProtKB=T1ENB0 T1ENB0 20198060 PTHR44170:SF56 PROTEIN SIDEKICK FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG70347|UniProtKB=T1G052 T1G052 20214450 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG167518|UniProtKB=T1EZG1 T1EZG1 20201961 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG89898|UniProtKB=T1G7J0 T1G7J0 20217037 PTHR11431:SF75 FERRITIN FERRITIN cation binding#GO:0043169;ferrous iron binding#GO:0008198;small molecule binding#GO:0036094;binding#GO:0005488;iron ion binding#GO:0005506;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;ion binding#GO:0043167 localization#GO:0051179;inorganic ion homeostasis#GO:0098771;cellular localization#GO:0051641;intracellular iron ion homeostasis#GO:0006879;maintenance of location#GO:0051235;maintenance of location in cell#GO:0051651;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;chemical homeostasis#GO:0048878;cellular process#GO:0009987;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 storage protein#PC00210 HELRO|EnsemblGenome=HelroG191032|UniProtKB=T1FSI7 T1FSI7 20211784 PTHR12898:SF1 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 24 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 24 molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG168579|UniProtKB=T1F0R4 T1F0R4 20202414 PTHR15116:SF16 DNA-BINDING PROTEIN SATB FAMILY MEMBER DEFECTIVE PROVENTRICULUS, ISOFORM A sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 protein-DNA complex organization#GO:0071824;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;cellular component organization#GO:0016043;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 Lambda repressor-like transcription factor#PC00245;DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG172487|UniProtKB=T1F5D9 T1F5D9 20204038 PTHR18945:SF925 NEUROTRANSMITTER GATED ION CHANNEL DUF4706 DOMAIN-CONTAINING PROTEIN ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG155552|UniProtKB=T1ELI8 T1ELI8 20197438 PTHR11787:SF8 RAB GDP-DISSOCIATION INHIBITOR RAB GDP DISSOCIATION INHIBITOR nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;cellular process#GO:0009987;transport#GO:0006810 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG107622|UniProtKB=T1EEB7 T1EEB7 20194919 PTHR11254:SF429 HECT DOMAIN UBIQUITIN-PROTEIN LIGASE E3 UBIQUITIN-PROTEIN LIGASE SU(DX) transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG64950|UniProtKB=T1FY19 T1FY19 20213717 PTHR18916:SF85 DYNACTIN 1-RELATED MICROTUBULE-BINDING TUBULIN-FOLDING COFACTOR B cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;microtubule plus-end binding#GO:0051010;binding#GO:0005488 cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987;cytoplasmic microtubule organization#GO:0031122 supramolecular complex#GO:0099080;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;microtubule plus-end#GO:0035371;microtubule#GO:0005874 chaperone#PC00072 HELRO|EnsemblGenome=HelroG165675|UniProtKB=T1EX56 T1EX56 20201156 PTHR34740:SF5 FINGER, C3HC4 TYPE, PUTATIVE-RELATED-RELATED POLYMERASE NUCLEOTIDYL TRANSFERASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG156953|UniProtKB=T1EM39 T1EM39 20197639 PTHR46029:SF7 C-TERMINAL-BINDING PROTEIN C-TERMINAL-BINDING PROTEIN molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;protein binding#GO:0005515;transcription factor binding#GO:0008134;DNA-binding transcription factor binding#GO:0140297 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transcription cofactor#PC00217 Wnt signaling pathway#P00057>C-terminal Binding Protein#P01439 HELRO|EnsemblGenome=HelroG167577|UniProtKB=T1EZI5 T1EZI5 20201985 PTHR31701:SF2 ENDOPLASMIC RETICULUM MEMBRANE-ASSOCIATED RNA DEGRADATION PROTEIN ENDOPLASMIC RETICULUM MEMBRANE-ASSOCIATED RNA DEGRADATION PROTEIN HELRO|EnsemblGenome=HelroG65745|UniProtKB=T1FYC2 T1FYC2 20213820 PTHR21223:SF2 CBY1-INTERACTING BAR DOMAIN-CONTAINING PROTEIN HOMOLOG CBY1-INTERACTING BAR DOMAIN-CONTAINING PROTEIN HOMOLOG organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cilium#GO:0005929;intracellular organelle#GO:0043229;ciliary transition zone#GO:0035869;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG62898|UniProtKB=T1FX70 T1FX70 20213418 PTHR13800:SF1 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPM monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic cation transport#GO:0006812;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG177633|UniProtKB=T1FBZ1 T1FBZ1 20206340 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG68668|UniProtKB=T1FZH9 T1FZH9 20214227 PTHR24057:SF0 GLYCOGEN SYNTHASE KINASE-3 ALPHA PROTEIN KINASE SHAGGY-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;developmental process#GO:0032502;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cell differentiation#GO:0030154;peptidyl-threonine phosphorylation#GO:0018107;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Glycogen Synthase Kinase-3Beta#P01441;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>GSK-3#P00902;PI3 kinase pathway#P00048>GSK3#P01181;Interleukin signaling pathway#P00036>GSK3#P00976;Ras Pathway#P04393>GSK3#P04546;Angiogenesis#P00005>GSK3beta#P00211;Alzheimer disease-presenilin pathway#P00004>GSK-3beta#P00175;PDGF signaling pathway#P00047>GSK3#P01153 HELRO|EnsemblGenome=HelroG193337|UniProtKB=T1FUW3 T1FUW3 20212609 PTHR34740:SF5 FINGER, C3HC4 TYPE, PUTATIVE-RELATED-RELATED POLYMERASE NUCLEOTIDYL TRANSFERASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169718|UniProtKB=T1F298 T1F298 20202948 PTHR46165:SF7 SET AND MYND DOMAIN-CONTAINING PROTEIN 4 SET AND MYND DOMAIN-CONTAINING PROTEIN 4 enzyme binding#GO:0019899;protein binding#GO:0005515;histone deacetylase binding#GO:0042826;binding#GO:0005488 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG171175|UniProtKB=T1F3W4 T1F3W4 20203513 PTHR39069:SF8 ECDYSONE-INDUCIBLE GENE E1, ISOFORM A FI17111P1 HELRO|EnsemblGenome=HelroG114869|UniProtKB=T1EG51 T1EG51 20195553 PTHR12277:SF81 ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN PROTEIN ABHD13 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185736|UniProtKB=T1FN79 T1FN79 20210277 PTHR12930:SF0 ZINC FINGER PROTEIN 183 RING FINGER PROTEIN 113B cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;U2-type spliceosomal complex#GO:0005684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG184710|UniProtKB=T1FLU0 T1FLU0 20209789 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178035|UniProtKB=T1FCN2 T1FCN2 20206581 PTHR12011:SF347 ADHESION G-PROTEIN COUPLED RECEPTOR FI21270P1-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG101462|UniProtKB=T1ED48 T1ED48 20194500 PTHR13036:SF0 BETA1,4 MANNOSYLTRANSFERASE CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE mannosyltransferase activity#GO:0000030;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG172694|UniProtKB=T1F5T0 T1F5T0 20204179 PTHR33332:SF48 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG71864|UniProtKB=T1G0S5 T1G0S5 20214673 PTHR12442:SF11 DYNEIN INTERMEDIATE CHAIN DYNEIN AXONEMAL INTERMEDIATE CHAIN 1 protein binding#GO:0005515;binding#GO:0005488 cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;outer dynein arm assembly#GO:0036158;cell projection organization#GO:0030030;microtubule cytoskeleton organization#GO:0000226;microtubule-based movement#GO:0007018;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;axoneme assembly#GO:0035082;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;cilium movement#GO:0003341;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection assembly#GO:0120031 axoneme#GO:0005930;outer dynein arm#GO:0036157;catalytic complex#GO:1902494;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;microtubule associated complex#GO:0005875;axonemal dynein complex#GO:0005858;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;ciliary plasm#GO:0097014;plasma membrane bounded cell projection cytoplasm#GO:0032838;membrane-bounded organelle#GO:0043227;dynein complex#GO:0030286;cell projection#GO:0042995;cytoskeleton#GO:0005856;cilium#GO:0005929 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG93275|UniProtKB=T1G8U8 T1G8U8 20217495 PTHR11915:SF442 SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN ALPHA-ACTININ, SARCOMERIC-RELATED cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;organelle organization#GO:0006996 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;cell cortex#GO:0005938;cell periphery#GO:0071944;cortical actin cytoskeleton#GO:0030864;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Integrin signalling pathway#P00034>alpha actinin#P00928 HELRO|EnsemblGenome=HelroG166765|UniProtKB=T1EYH7 T1EYH7 20201627 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG178626|UniProtKB=T1FDG9 T1FDG9 20206868 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190929|UniProtKB=T1FSF6 T1FSF6 20211753 PTHR45617:SF165 LEUCINE RICH REPEAT FAMILY PROTEIN COMMON DPR-INTERACTING PROTEIN-RELATED scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG153340|UniProtKB=T1EL44 T1EL44 20197294 PTHR46289:SF17 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG67088|UniProtKB=T1FYW0 T1FYW0 20214008 PTHR21231:SF3 XPA-BINDING PROTEIN 1-RELATED GPN-LOOP GTPASE 2 hydrolase activity#GO:0016787;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 small GTPase#PC00208;G-protein#PC00020;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG152396|UniProtKB=T1EKR3 T1EKR3 20197163 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG96495|UniProtKB=T1G9C5 T1G9C5 20217672 PTHR11893:SF36 INNEXIN INNEXIN-5 cell junction protein#PC00070;gap junction#PC00105 HELRO|EnsemblGenome=HelroG162966|UniProtKB=T1ETG1 T1ETG1 20199861 PTHR47510:SF3 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194635|UniProtKB=T1FW93 T1FW93 20213089 PTHR10258:SF8 CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA CALCIUM-ACTIVATED POTASSIUM CHANNEL BK ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;molecular function regulator activity#GO:0098772;transporter regulator activity#GO:0141108;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic ion-gated channel activity#GO:0022839;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium-activated cation channel activity#GO:0005227;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;potassium channel regulator activity#GO:0015459;ligand-gated monoatomic cation channel activity#GO:0099094;channel regulator activity#GO:0016247;monoatomic ion channel activity#GO:0005216;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 detection of stimulus#GO:0051606;response to stimulus#GO:0050896;response to chemical#GO:0042221;detection of chemical stimulus#GO:0009593 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG179619|UniProtKB=T1FEY1 T1FEY1 20207380 PTHR16151:SF2 HAUS AUGMIN-LIKE COMPLEX SUBUNIT 6 HAUS AUGMIN-LIKE COMPLEX SUBUNIT 6 cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule-based process#GO:0007017;organelle organization#GO:0006996 supramolecular complex#GO:0099080;spindle microtubule#GO:0005876;cellular anatomical entity#GO:0110165;supramolecular fiber#GO:0099512;supramolecular polymer#GO:0099081;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;mitotic spindle#GO:0072686;microtubule cytoskeleton#GO:0015630;cytoskeleton#GO:0005856;spindle#GO:0005819;microtubule#GO:0005874 HELRO|EnsemblGenome=HelroG73860|UniProtKB=T1G1J5 T1G1J5 20214943 PTHR19965:SF82 RNA AND EXPORT FACTOR BINDING PROTEIN THO COMPLEX SUBUNIT 4 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;mRNA transport#GO:0051028;RNA localization#GO:0006403;localization#GO:0051179;organic substance transport#GO:0071702;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG159462|UniProtKB=T1EP23 T1EP23 20198323 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG182434|UniProtKB=T1FI69 T1FI69 20208518 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG77097|UniProtKB=T1G2T1 T1G2T1 20215379 PTHR47978:SF40 FAMILY NOT NAMED RAS-RELATED PROTEIN RAB-33 GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG63495|UniProtKB=T1FXG5 T1FXG5 20213513 PTHR11537:SF252 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;delayed rectifier potassium channel activity#GO:0005251;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG159243|UniProtKB=T1ENS5 T1ENS5 20198225 PTHR13379:SF0 UNCHARACTERIZED DUF1308 UPF0415 PROTEIN C7ORF25 HELRO|EnsemblGenome=HelroG114857|UniProtKB=T1EG50 T1EG50 20195552 PTHR12461:SF43 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED HSPB1-ASSOCIATED PROTEIN 1 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG77310|UniProtKB=T1G2W0 T1G2W0 20215408 PTHR46289:SF17 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185718|UniProtKB=T1FN70 T1FN70 20210268 PTHR12642:SF0 RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of 5.8S rRNA#GO:0000460;maturation of LSU-rRNA#GO:0000470;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;preribosome, large subunit precursor#GO:0030687;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981 HELRO|EnsemblGenome=HelroG192839|UniProtKB=T1FUC5 T1FUC5 20212421 PTHR24115:SF0 KINESIN-RELATED FI21273P1-RELATED pyrophosphatase activity#GO:0016462;cytoskeletal protein binding#GO:0008092;microtubule motor activity#GO:0003777;tubulin binding#GO:0015631;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;cytoskeletal motor activity#GO:0003774;microtubule binding#GO:0008017;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017;cellular process#GO:0009987 supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;cytoskeleton#GO:0005856;microtubule#GO:0005874;spindle#GO:0005819 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG164051|UniProtKB=T1EUU1 T1EUU1 20200341 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED BRCT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190733|UniProtKB=T1FS90 T1FS90 20211687 PTHR16207:SF11 SET DOMAIN-CONTAINING PROTEIN SET DOMAIN-CONTAINING PROTEIN membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG85456|UniProtKB=T1G5X3 T1G5X3 20216470 PTHR24096:SF149 LONG-CHAIN-FATTY-ACID--COA LIGASE AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED ligase activity#GO:0016874;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 metabolite interconversion enzyme#PC00262;ligase#PC00142 HELRO|EnsemblGenome=HelroG159094|UniProtKB=T1ENK9 T1ENK9 20198159 PTHR13022:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K translation regulator activity#GO:0045182;nucleic acid binding#GO:0003676;translation regulator activity, nucleic acid binding#GO:0090079;translation initiation factor activity#GO:0003743;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation factor activity, RNA binding#GO:0008135 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical entity#GO:0110165;eukaryotic translation initiation factor 3 complex#GO:0005852;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG194022|UniProtKB=T1FVK7 T1FVK7 20212853 PTHR46507:SF4 AFADIN- AND ALPHA-ACTININ-BINDING PROTEIN SSX FAMILY MEMBER 2 INTERACTING PROTEIN cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;cilium assembly#GO:0060271;cell projection organization#GO:0030030;transport#GO:0006810;microtubule-based movement#GO:0007018;cellular component organization#GO:0016043;intraciliary transport involved in cilium assembly#GO:0035735;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;transport along microtubule#GO:0010970;cell projection assembly#GO:0030031;intraciliary transport#GO:0042073;localization#GO:0051179;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based transport#GO:0099111;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;organelle organization#GO:0006996;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;plasma membrane bounded cell projection assembly#GO:0120031;protein-containing complex localization#GO:0031503 microtubule organizing center#GO:0005815;centriolar satellite#GO:0034451;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;centrosome#GO:0005813;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG110606|UniProtKB=T1EF35 T1EF35 20195187 PTHR31353:SF1 FAM98 PROTEIN FAM98B RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG164165|UniProtKB=T1EV11 T1EV11 20200411 PTHR47537:SF6 CUBILIN CUB DOMAIN-CONTAINING PROTEIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG82387|UniProtKB=T1G4R6 T1G4R6 20216064 PTHR24068:SF74 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2-17 KDA ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E2#P01491 HELRO|EnsemblGenome=HelroG98395|UniProtKB=T1G9M3 T1G9M3 20217769 PTHR20856:SF8 DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2 DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC2 catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;RNA polymerase activity#GO:0097747;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;RNA polymerase III activity#GO:0001056 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;nuclear DNA-directed RNA polymerase complex#GO:0055029;RNA polymerase III complex#GO:0005666;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG163337|UniProtKB=T1ETX6 T1ETX6 20200026 PTHR47023:SF1 SEX PEPTIDE RECEPTOR SEX PEPTIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG112884|UniProtKB=T1EFM9 T1EFM9 20195381 PTHR19134:SF542 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE S hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 cellular component organization or biogenesis#GO:0071840;synapse organization#GO:0050808;cell junction organization#GO:0034330;cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;synaptic membrane adhesion#GO:0099560;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cellular process#GO:0009987 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG76832|UniProtKB=T1G2P9 T1G2P9 20215347 PTHR11675:SF131 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 9-RELATED transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG184329|UniProtKB=T1FL05 T1FL05 20209504 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG81400|UniProtKB=T1G4E0 T1G4E0 20215938 PTHR42780:SF1 SOLEUCYL-TRNA SYNTHETASE ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG186154|UniProtKB=T1FNQ8 T1FNQ8 20210455 PTHR10283:SF82 SOLUTE CARRIER FAMILY 13 MEMBER SOLUTE CARRIER FAMILY 13 MEMBER 2 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG160625|UniProtKB=T1EQI4 T1EQI4 20198834 PTHR14596:SF72 ZINC FINGER PROTEIN ZINC FINGER PROTEIN MSN2-RELATED cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to nutrient levels#GO:0031667;response to extracellular stimulus#GO:0009991;response to stress#GO:0006950;response to starvation#GO:0042594 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG85733|UniProtKB=T1G625 T1G625 20216522 PTHR21013:SF10 ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2 chaperone#PC00072 HELRO|EnsemblGenome=HelroG128997|UniProtKB=T1EHR2 T1EHR2 20196112 PTHR10217:SF637 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL EAG-LIKE K[+] CHANNEL, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG107810|UniProtKB=T1EEC8 T1EEC8 20194930 PTHR31441:SF2 FOLLICULIN FAMILY MEMBER FOLLICULIN nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of cell communication#GO:0010646;positive regulation of TORC1 signaling#GO:1904263;regulation of TORC1 signaling#GO:1903432;positive regulation of signal transduction#GO:0009967;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of TOR signaling#GO:0032006;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;regulation of cellular process#GO:0050794;positive regulation of TOR signaling#GO:0032008;regulation of signal transduction#GO:0009966;positive regulation of cell communication#GO:0010647;biological regulation#GO:0065007;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG189253|UniProtKB=T1FQV5 T1FQV5 20211202 PTHR23281:SF39 MERLIN/MOESIN/EZRIN/RADIXIN MOESIN_EZRIN_RADIXIN HOMOLOG 2 cytoskeletal protein binding#GO:0008092;integrin binding#GO:0005178;binding#GO:0005488;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;signaling receptor binding#GO:0005102;actin binding#GO:0003779 regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of cell population proliferation#GO:0042127;regulation of anatomical structure morphogenesis#GO:0022603;regulation of organelle organization#GO:0033043;regulation of signaling#GO:0023051;positive regulation of transport#GO:0051050;regulation of localization#GO:0032879;regulation of cellular component organization#GO:0051128;regulation of cellular localization#GO:0060341;regulation of intracellular signal transduction#GO:1902531;regulation of vesicle-mediated transport#GO:0060627;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of transport#GO:0051049;regulation of cell shape#GO:0008360;regulation of biological quality#GO:0065008;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;regulation of signal transduction#GO:0009966;regulation of organelle assembly#GO:1902115;biological regulation#GO:0065007;negative regulation of cell population proliferation#GO:0008285;positive regulation of protein localization#GO:1903829;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;regulation of protein localization#GO:0032880 filopodium#GO:0030175;anchoring junction#GO:0070161;cell-cell junction#GO:0005911;cell junction#GO:0030054;actin-based cell projection#GO:0098858;adherens junction#GO:0005912;cell projection#GO:0042995;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;plasma membrane#GO:0005886;apical part of cell#GO:0045177 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG114532|UniProtKB=T1EG25 T1EG25 20195527 PTHR48036:SF6 SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED RNA BINDING MOTIF PROTEIN 39B ISOFORM X1-RELATED ribonucleoprotein complex binding#GO:0043021;protein-containing complex binding#GO:0044877;binding#GO:0005488 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG100685|UniProtKB=T1ED11 T1ED11 20194463 PTHR10572:SF24 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE reductase#PC00198;oxidoreductase#PC00176 Cholesterol biosynthesis#P00014>Hydroxymethyl glutaryl CoA reductase#P00491 HELRO|EnsemblGenome=HelroG189182|UniProtKB=T1FQR4 T1FQR4 20211161 PTHR12386:SF12 ATP SYNTHASE SUBUNIT ATP SYNTHASE SUBUNIT G 2, MITOCHONDRIAL-RELATED monoatomic cation channel activity#GO:0005261;ligase activity#GO:0016874;inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;catalytic activity#GO:0003824;proton transmembrane transporter activity#GO:0015078;proton channel activity#GO:0015252;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;inorganic cation transmembrane transporter activity#GO:0022890;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 cellular aromatic compound metabolic process#GO:0006725;ribonucleoside triphosphate metabolic process#GO:0009199;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative metabolic process#GO:1901135;ATP biosynthetic process#GO:0006754;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;purine nucleoside triphosphate biosynthetic process#GO:0009145;heterocycle metabolic process#GO:0046483;purine ribonucleoside triphosphate metabolic process#GO:0009205;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;ribonucleoside triphosphate biosynthetic process#GO:0009201;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;proton motive force-driven ATP synthesis#GO:0015986;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;purine nucleoside triphosphate metabolic process#GO:0009144;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;proton-transporting two-sector ATPase complex, proton-transporting domain#GO:0033177;ATPase complex#GO:1904949;organelle inner membrane#GO:0019866;mitochondrial proton-transporting ATP synthase complex#GO:0005753;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;proton-transporting two-sector ATPase complex#GO:0016469;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)#GO:0000276;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;proton-transporting ATP synthase complex, coupling factor F(o)#GO:0045263;proton-transporting ATP synthase complex#GO:0045259;mitochondrial protein-containing complex#GO:0098798 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG182967|UniProtKB=T1FJ03 T1FJ03 20208802 PTHR10656:SF42 CELL FATE DETERMINING PROTEIN MAB21-RELATED CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED transferase#PC00220;nucleotidyltransferase#PC00174;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG177680|UniProtKB=T1FC26 T1FC26 20206375 PTHR46989:SF3 USP DOMAIN-CONTAINING PROTEIN USPA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172027|UniProtKB=T1F4Y6 T1F4Y6 20203885 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193596|UniProtKB=T1FV57 T1FV57 20212703 PTHR10131:SF151 TNF RECEPTOR ASSOCIATED FACTOR TNF RECEPTOR ASSOCIATED FACTOR (TRAF) HOMOLOG regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;regulation of canonical NF-kappaB signal transduction#GO:0043122;regulation of signaling#GO:0023051;biological regulation#GO:0065007;regulation of intracellular signal transduction#GO:1902531 receptor complex#GO:0043235;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG95422|UniProtKB=T1G957 T1G957 20217604 PTHR43829:SF9 AQUAPORIN OR AQUAGLYCEROPORIN RELATED AQUAPORIN-9 passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;channel activity#GO:0015267;carbohydrate transmembrane transporter activity#GO:0015144 localization#GO:0051179;organic hydroxy compound transport#GO:0015850;organic substance transport#GO:0071702;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;cellular process#GO:0009987;carbohydrate transmembrane transport#GO:0034219;carbohydrate transport#GO:0008643 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG182159|UniProtKB=T1FHU5 T1FHU5 20208394 PTHR11449:SF1 RIBOSOMAL PROTEIN L30 LARGE RIBOSOMAL SUBUNIT PROTEIN EL30 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG80833|UniProtKB=T1G461 T1G461 20215859 PTHR16515:SF66 PR DOMAIN ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG73251|UniProtKB=T1G1C1 T1G1C1 20214869 PTHR14463:SF10 LIPASE MATURATION FACTOR LIPASE MATURATION FACTOR 1 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG191088|UniProtKB=T1FSK8 T1FSK8 20211805 PTHR15549:SF6 PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR MID2 DOMAIN-CONTAINING PROTEIN immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG146344|UniProtKB=T1EJR8 T1EJR8 20196818 PTHR15314:SF1 RIBONUCLEASE P PROTEIN SUBUNIT P20 RIBONUCLEASE P PROTEIN SUBUNIT P20 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG113120|UniProtKB=T1EFQ3 T1EFQ3 20195405 PTHR45630:SF7 CATION-TRANSPORTING ATPASE-RELATED ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;active monoatomic ion transmembrane transporter activity#GO:0022853;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;P-type ion transporter activity#GO:0015662;ATPase-coupled transmembrane transporter activity#GO:0042626;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075 inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;transmembrane transport#GO:0055085;transport#GO:0006810;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;cellular process#GO:0009987;chemical homeostasis#GO:0048878;intracellular calcium ion homeostasis#GO:0006874;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;establishment of localization#GO:0051234;intracellular monoatomic cation homeostasis#GO:0030003;intracellular monoatomic ion homeostasis#GO:0006873 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG92881|UniProtKB=T1G8M9 T1G8M9 20217426 PTHR11267:SF196 T-BOX PROTEIN-RELATED T-BOX PROTEIN 30_42-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cell fate commitment#GO:0045165;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;cell fate specification#GO:0001708;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HELRO|EnsemblGenome=HelroG165474|UniProtKB=T1EWV4 T1EWV4 20201054 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG172462|UniProtKB=T1F5C9 T1F5C9 20204028 PTHR24324:SF9 HOMEOBOX PROTEIN HHEX HOMEOBOX DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG184293|UniProtKB=T1FKX5 T1FKX5 20209474 PTHR45698:SF1 TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG191596|UniProtKB=T1FT41 T1FT41 20211988 PTHR10514:SF27 ANGIOTENSIN-CONVERTING ENZYME ANGIOTENSIN-CONVERTING ENZYME metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG100974|UniProtKB=T1ED25 T1ED25 20194477 PTHR14360:SF1 PROTEIN FMP32, MITOCHONDRIAL PROTEIN FMP32, MITOCHONDRIAL cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG167271|UniProtKB=T1EZ75 T1EZ75 20201875 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG175520|UniProtKB=T1F9C7 T1F9C7 20205426 PTHR10742:SF405 FLAVIN MONOAMINE OXIDASE PEROXISOMAL N(1)-ACETYL-SPERMINE_SPERMIDINE OXIDASE oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 oxidase#PC00175;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG190996|UniProtKB=T1FSH5 T1FSH5 20211772 PTHR24416:SF566 TYROSINE-PROTEIN KINASE RECEPTOR EPIDERMAL GROWTH FACTOR RECEPTOR signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 negative regulation of biological process#GO:0048519;signal transduction#GO:0007165;neurogenesis#GO:0022008;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;positive regulation of cell population proliferation#GO:0008284;regulation of catalytic activity#GO:0050790;nervous system development#GO:0007399;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;system development#GO:0048731;cell differentiation#GO:0030154;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;negative regulation of programmed cell death#GO:0043069;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;regulation of programmed cell death#GO:0043067;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;cellular developmental process#GO:0048869;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;regulation of apoptotic process#GO:0042981;regulation of cell population proliferation#GO:0042127;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;negative regulation of apoptotic process#GO:0043066;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;anatomical structure development#GO:0048856;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 basal plasma membrane#GO:0009925;receptor complex#GO:0043235;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;basal part of cell#GO:0045178;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 EGF receptor signaling pathway#P00018>EGFR#P00542;Cadherin signaling pathway#P00012>EGFR#P00466 HELRO|EnsemblGenome=HelroG173490|UniProtKB=T1F6V8 T1F6V8 20204557 PTHR31395:SF26 SHISA STANLEY-CUP scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185674|UniProtKB=T1FN47 T1FN47 20210245 PTHR18884:SF67 SEPTIN SEPTIN-2 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 localization#GO:0051179;cell division#GO:0051301;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;cytoskeleton-dependent cytokinesis#GO:0061640;cell cycle process#GO:0022402;cell cycle#GO:0007049;cellular process#GO:0009987;cytokinesis#GO:0000910;protein localization#GO:0008104 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;cell division site#GO:0032153;cell cortex#GO:0005938;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085 Parkinson disease#P00049>CDCrel-1#P01226 HELRO|EnsemblGenome=HelroG194539|UniProtKB=T1FW63 T1FW63 20213059 PTHR23204:SF10 CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 6 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;mRNA 3'-end processing#GO:0031124;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mRNA processing#GO:0006397;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;mRNA cleavage factor complex#GO:0005849;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG155823|UniProtKB=T1ELM8 T1ELM8 20197478 PTHR24205:SF4 FOUR AND A HALF LIM DOMAINS PROTEIN PROTEIN ESPINAS molecular adaptor activity#GO:0060090;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;protein-macromolecule adaptor activity#GO:0030674 supramolecular complex#GO:0099080;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;Z disc#GO:0030018;cellular anatomical entity#GO:0110165;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;contractile fiber#GO:0043292;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;sarcomere#GO:0030017;membrane-bounded organelle#GO:0043227;myofibril#GO:0030016;I band#GO:0031674 transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG90867|UniProtKB=T1G7X1 T1G7X1 20217168 PTHR45837:SF3 VESICLE-TRAFFICKING PROTEIN SEC22B VESICLE-TRAFFICKING PROTEIN SEC22B molecular adaptor activity#GO:0060090;SNAP receptor activity#GO:0005484;protein-macromolecule adaptor activity#GO:0030674 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;vesicle fusion#GO:0006906;cellular localization#GO:0051641;Golgi organization#GO:0007030;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;membrane fusion#GO:0061025;establishment of localization#GO:0051234;organelle organization#GO:0006996;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;establishment of localization in cell#GO:0051649;vesicle organization#GO:0016050;intracellular transport#GO:0046907;organelle fusion#GO:0048284 bounding membrane of organelle#GO:0098588;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular membrane-bounded organelle#GO:0043231;SNARE complex#GO:0031201;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;transport vesicle membrane#GO:0030658;endoplasmic reticulum subcompartment#GO:0098827;cytoplasmic vesicle membrane#GO:0030659;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;membrane protein complex#GO:0098796;ER to Golgi transport vesicle membrane#GO:0012507;intracellular vesicle#GO:0097708;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;Golgi apparatus#GO:0005794;organelle subcompartment#GO:0031984;membrane#GO:0016020;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;coated vesicle membrane#GO:0030662;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;transport vesicle#GO:0030133;Golgi membrane#GO:0000139;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG185644|UniProtKB=T1FN31 T1FN31 20210230 PTHR12592:SF0 ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE cellular metabolic process#GO:0044237;cellular process#GO:0009987;metabolic process#GO:0008152 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG155740|UniProtKB=T1ELL8 T1ELL8 20197468 PTHR12241:SF162 TUBULIN POLYGLUTAMYLASE TUBULIN MONOGLUTAMYLASE TTLL4 cytoskeletal protein binding#GO:0008092;ligase activity#GO:0016874;protein binding#GO:0005515;tubulin binding#GO:0015631;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;microtubule cytoskeleton organization#GO:0000226;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;cellular component organization#GO:0016043;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;nitrogen compound metabolic process#GO:0006807;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;cilium#GO:0005929;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG184901|UniProtKB=T1FM53 T1FM53 20209902 PTHR16222:SF26 ADP-RIBOSYLGLYCOHYDROLASE ADP-RIBOSYLHYDROLASE ARH1 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG194219|UniProtKB=T1FVT7 T1FVT7 20212933 PTHR45965:SF3 INACTIVE RHOMBOID PROTEIN INACTIVE RHOMBOID PROTEIN 1 regulation of cell communication#GO:0010646;regulation of protein secretion#GO:0050708;regulation of signaling#GO:0023051;regulation of secretion by cell#GO:1903530;regulation of localization#GO:0032879;regulation of cellular localization#GO:0060341;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;regulation of transport#GO:0051049;regulation of cellular process#GO:0050794;regulation of secretion#GO:0051046;regulation of signal transduction#GO:0009966;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;biological regulation#GO:0065007;regulation of ERBB signaling pathway#GO:1901184;regulation of protein transport#GO:0051223;regulation of establishment of protein localization#GO:0070201;regulation of protein localization#GO:0032880 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG159507|UniProtKB=T1EP41 T1EP41 20198341 PTHR20932:SF8 LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN LD22649P HELRO|EnsemblGenome=HelroG172447|UniProtKB=T1F5C4 T1F5C4 20204023 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158373|UniProtKB=T1EMQ1 T1EMQ1 20197851 PTHR19325:SF574 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING SUSHI, VON WILLEBRAND FACTOR TYPE A, EGF AND PENTRAXIN DOMAIN-CONTAINING PROTEIN 1 complement component#PC00078 HELRO|EnsemblGenome=HelroG187914|UniProtKB=T1FPG9 T1FPG9 20210716 PTHR42850:SF4 METALLOPHOSPHOESTERASE ZINC-DEPENDENT ENDOPOLYPHOSPHATASE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG178826|UniProtKB=T1FDS8 T1FDS8 20206977 PTHR10334:SF498 CYSTEINE-RICH SECRETORY PROTEIN-RELATED MIP16674P defense/immunity protein#PC00090 PI3 kinase pathway#P00048>scl-1#G01545 HELRO|EnsemblGenome=HelroG79716|UniProtKB=T1G3S7 T1G3S7 20215725 PTHR10314:SF194 CYSTATHIONINE BETA-SYNTHASE CYSTATHIONINE BETA-SYNTHASE transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;sulfur compound metabolic process#GO:0006790;proteinogenic amino acid biosynthetic process#GO:0170038;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;alpha-amino acid biosynthetic process#GO:1901607;nitrogen compound metabolic process#GO:0006807;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;small molecule biosynthetic process#GO:0044283;L-amino acid biosynthetic process#GO:0170034;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 lyase#PC00144 Cysteine biosynthesis#P02737>O-Acetylserine-lyase#P02887 HELRO|EnsemblGenome=HelroG66644|UniProtKB=T1FYN4 T1FYN4 20213932 PTHR13693:SF3 CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE LD36009P transaminase#PC00216;transferase#PC00220;metabolite interconversion enzyme#PC00262 Biotin biosynthesis#P02731>8-Amino-7-oxononanoate synthase#P02858 HELRO|EnsemblGenome=HelroG172004|UniProtKB=T1F4X7 T1F4X7 20203876 PTHR24260:SF136 FAMILY NOT NAMED GH08193P-RELATED HELRO|EnsemblGenome=HelroG178827|UniProtKB=T1FDS9 T1FDS9 20206978 PTHR10334:SF498 CYSTEINE-RICH SECRETORY PROTEIN-RELATED MIP16674P defense/immunity protein#PC00090 PI3 kinase pathway#P00048>scl-1#G01545 HELRO|EnsemblGenome=HelroG110647|UniProtKB=T1EF39 T1EF39 20195191 PTHR11129:SF1 PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA prenyltransferase activity#GO:0004659;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;protein modification process#GO:0036211;cellular process#GO:0009987;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;transferase complex#GO:1990234 acyltransferase#PC00042;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG176987|UniProtKB=T1FB35 T1FB35 20206034 PTHR23202:SF124 WASP INTERACTING PROTEIN-RELATED C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG168634|UniProtKB=T1F0T6 T1F0T6 20202436 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG155765|UniProtKB=T1ELM2 T1ELM2 20197472 PTHR13832:SF565 PROTEIN PHOSPHATASE 2C AT28366P-RELATED macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;dephosphorylation#GO:0016311;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG112672|UniProtKB=T1EFL2 T1EFL2 20195364 PTHR21245:SF15 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN RRM DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG181069|UniProtKB=T1FGK7 T1FGK7 20207956 PTHR24023:SF1105 COLLAGEN ALPHA FIBRILLAR COLLAGEN NC1 DOMAIN-CONTAINING PROTEIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG160110|UniProtKB=T1EPT3 T1EPT3 20198583 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166845|UniProtKB=T1EYM2 T1EYM2 20201672 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182462|UniProtKB=T1FI84 T1FI84 20208533 PTHR16021:SF18 MANSC DOMAIN CONTAINING PROTEIN 1 GROUP-SPECIFIC ANTIGEN HELRO|EnsemblGenome=HelroG156467|UniProtKB=T1ELX1 T1ELX1 20197571 PTHR43289:SF6 MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED SERINE_THREONINE-PROTEIN KINASE NEKL-3 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;peptidyl-amino acid modification#GO:0018193;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;nitrogen compound metabolic process#GO:0006807;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG171470|UniProtKB=T1F4B9 T1F4B9 20203668 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG185177|UniProtKB=T1FMH1 T1FMH1 20210020 PTHR10977:SF3 DIPHOSPHOMEVALONATE DECARBOXYLASE DIPHOSPHOMEVALONATE DECARBOXYLASE decarboxylase#PC00089 Cholesterol biosynthesis#P00014>Diphosphomevalonate decarboxylase#P00496 HELRO|EnsemblGenome=HelroG75597|UniProtKB=T1G270 T1G270 20215168 PTHR45712:SF22 AGAP008170-PA INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT HELRO|EnsemblGenome=HelroG65323|UniProtKB=T1FY62 T1FY62 20213760 PTHR12169:SF6 ATPASE N2B AFG1-LIKE ATPASE pyrophosphatase activity#GO:0016462;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG66074|UniProtKB=T1FYG6 T1FYG6 20213864 PTHR20951:SF2 C13ORF1 PROTEIN-RELATED SPRY DOMAIN-CONTAINING PROTEIN 7 HELRO|EnsemblGenome=HelroG170463|UniProtKB=T1F335 T1F335 20203234 PTHR15551:SF3 LIM DOMAIN ONLY 7 LIM AND CALPONIN HOMOLOGY DOMAINS-CONTAINING PROTEIN 1 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG158597|UniProtKB=T1EN00 T1EN00 20197950 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG112421|UniProtKB=T1EFJ7 T1EFJ7 20195349 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG103239|UniProtKB=T1EDF1 T1EDF1 20194603 PTHR12696:SF0 TIP120 CULLIN-ASSOCIATED NEDD8-DISSOCIATED PROTEIN 1 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein-containing complex assembly#GO:0065003;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular component organization#GO:0016043;cellular process#GO:0009987;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nitrogen compound metabolic process#GO:0006807;protein-containing complex organization#GO:0043933;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191630|UniProtKB=T1FT54 T1FT54 20212001 PTHR13678:SF2 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A cellular localization#GO:0051641;macromolecule localization#GO:0033036;protein targeting to vacuole#GO:0006623;transport#GO:0006810;protein catabolic process#GO:0030163;nitrogen compound transport#GO:0071705;organonitrogen compound catabolic process#GO:1901565;establishment of protein localization#GO:0045184;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;modification-dependent macromolecule catabolic process#GO:0043632;organic substance transport#GO:0071702;establishment of protein localization to membrane#GO:0090150;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein localization to organelle#GO:0033365;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;localization within membrane#GO:0051668;macromolecule catabolic process#GO:0009057;establishment of protein localization to vacuole#GO:0072666;modification-dependent protein catabolic process#GO:0019941;vacuolar transport#GO:0007034;macromolecule metabolic process#GO:0043170;protein localization to membrane#GO:0072657;protein localization to vacuole#GO:0072665;protein targeting#GO:0006605;organonitrogen compound metabolic process#GO:1901564;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein localization#GO:0008104;ubiquitin-dependent protein catabolic process#GO:0006511;localization#GO:0051179;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endosome membrane#GO:0010008;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ESCRT I complex#GO:0000813;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cytoplasmic vesicle membrane#GO:0030659 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG164015|UniProtKB=T1EUR7 T1EUR7 20200317 PTHR46289:SF19 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED ZINC FINGER MYM-TYPE CONTAINING 1 HELRO|EnsemblGenome=HelroG116366|UniProtKB=T1EGE3 T1EGE3 20195645 PTHR22957:SF547 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 16 nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of GTPase activity#GO:0043087;regulation of molecular function#GO:0065009;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;activation of GTPase activity#GO:0090630;biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG92504|UniProtKB=T1G8H8 T1G8H8 20217375 PTHR19969:SF19 SH2-SH3 ADAPTOR PROTEIN-RELATED SH2 DOMAIN-CONTAINING PROTEIN molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;enzyme binding#GO:0019899;protein binding#GO:0005515;protein kinase binding#GO:0019901;protein tyrosine kinase binding#GO:1990782;receptor tyrosine kinase binding#GO:0030971;signaling receptor binding#GO:0005102;kinase binding#GO:0019900 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;cell communication#GO:0007154;cell motility#GO:0048870;cellular process#GO:0009987;cell migration#GO:0016477;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG175729|UniProtKB=T1F9L2 T1F9L2 20205511 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG185663|UniProtKB=T1FN40 T1FN40 20210238 PTHR10410:SF5 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14 ubiquitin-like protein peptidase activity#GO:0019783;proteasome binding#GO:0070628;metallopeptidase activity#GO:0008237;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;protein-containing complex binding#GO:0044877;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;protein modification by small protein removal#GO:0070646;proteolysis#GO:0006508;protein deubiquitination#GO:0016579;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 peptidase complex#GO:1905368;proteasome accessory complex#GO:0022624;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;proteasome regulatory particle#GO:0005838;catalytic complex#GO:1902494;proteasome regulatory particle, lid subcomplex#GO:0008541;proteasome complex#GO:0000502;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;endopeptidase complex#GO:1905369;membrane-bounded organelle#GO:0043227 translation initiation factor#PC00224;translation factor#PC00223 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489;Cell cycle#P00013>Proteasome#P00480 HELRO|EnsemblGenome=HelroG101144|UniProtKB=T1ED32 T1ED32 20194484 PTHR46203:SF1 PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65 MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE translation release factor#PC00225;translation factor#PC00223 HELRO|EnsemblGenome=HelroG185231|UniProtKB=T1FMJ4 T1FMJ4 20210043 PTHR47385:SF14 CALPONIN TRANSGELIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG124437|UniProtKB=T1EH14 T1EH14 20195864 PTHR16007:SF15 EPIDIDYMAL MEMBRANE PROTEIN E9-RELATED TRANSMEMBRANE PROTEIN 45B HELRO|EnsemblGenome=HelroG75054|UniProtKB=T1G1Z9 T1G1Z9 20215097 PTHR12867:SF6 GLYCOSYL TRANSFERASE-RELATED N-ACETYLGLUCOSAMINYLDIPHOSPHODOLICHOL N-ACETYLGLUCOSAMINYLTRANSFERASE transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG177285|UniProtKB=T1FBG3 T1FBG3 20206162 PTHR46731:SF1 F-BOX ONLY PROTEIN 15 F-BOX ONLY PROTEIN 15 SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234 HELRO|EnsemblGenome=HelroG164779|UniProtKB=T1EVT0 T1EVT0 20200680 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG164007|UniProtKB=T1EUR3 T1EUR3 20200313 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG71547|UniProtKB=T1G0N1 T1G0N1 20214629 PTHR24064:SF577 SOLUTE CARRIER FAMILY 22 MEMBER GH09241P secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG162123|UniProtKB=T1ES94 T1ES94 20199444 PTHR23246:SF13 NEW-GLUE PROTEIN GH12359P HELRO|EnsemblGenome=HelroG79038|UniProtKB=T1G3J0 T1G3J0 20215638 PTHR14586:SF1 THIAMINE-TRIPHOSPHATASE THIAMINE-TRIPHOSPHATASE cation binding#GO:0043169;pyrophosphatase activity#GO:0016462;magnesium ion binding#GO:0000287;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;metal ion binding#GO:0046872;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;sulfur compound metabolic process#GO:0006790;pyrimidine-containing compound metabolic process#GO:0072527;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;dephosphorylation#GO:0016311;organophosphate metabolic process#GO:0019637;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 phosphatase#PC00181;hydrolase#PC00121 Thiamin metabolism#P02780>Thiamine triphosphatase#P03184 HELRO|EnsemblGenome=HelroG192764|UniProtKB=T1FU97 T1FU97 20212393 PTHR15508:SF8 RIBOSOMAL PROTEIN S6 KINASE LD24550P non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG193936|UniProtKB=T1FVH6 T1FVH6 20212822 PTHR12280:SF20 PANTOTHENATE KINASE 4'-PHOSPHOPANTETHEINE PHOSPHATASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 kinase#PC00137 Coenzyme A biosynthesis#P02736>Pantothenate kinase#P02885 HELRO|EnsemblGenome=HelroG180690|UniProtKB=T1FG63 T1FG63 20207812 PTHR14725:SF0 RIBOSOME-BINDING FACTOR A, MITOCHONDRIAL-RELATED RIBOSOME-BINDING FACTOR A, MITOCHONDRIAL-RELATED HELRO|EnsemblGenome=HelroG162763|UniProtKB=T1ET37 T1ET37 20199737 PTHR21284:SF12 EG:80H7.2 PROTEIN EG:80H7.2 PROTEIN HELRO|EnsemblGenome=HelroG178468|UniProtKB=T1FD76 T1FD76 20206775 PTHR22765:SF416 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE GODZILLA transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG170911|UniProtKB=T1F3L2 T1F3L2 20203411 PTHR45632:SF17 LD33804P KELCH-LIKE PROTEIN 31 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG168100|UniProtKB=T1F061 T1F061 20202211 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG105641|UniProtKB=T1EDX0 T1EDX0 20194772 PTHR10554:SF12 SYNTROPHIN IP02644P membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;plasma membrane protein complex#GO:0098797;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG124858|UniProtKB=T1EH32 T1EH32 20195882 PTHR14549:SF2 TRANSMEMBRANE PROTEIN 223 TRANSMEMBRANE PROTEIN 223 HELRO|EnsemblGenome=HelroG179298|UniProtKB=T1FEI1 T1FEI1 20207230 PTHR22802:SF463 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG188706|UniProtKB=T1FQA1 T1FQA1 20210998 PTHR11771:SF153 LIPOXYGENASE LIPOXYGENASE DOMAIN-CONTAINING PROTEIN oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;dioxygenase activity#GO:0051213 lipid metabolic process#GO:0006629;lipid oxidation#GO:0034440;cellular metabolic process#GO:0044237;lipid modification#GO:0030258;cellular lipid metabolic process#GO:0044255;cellular process#GO:0009987;metabolic process#GO:0008152;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG157732|UniProtKB=T1EME8 T1EME8 20197748 PTHR24346:SF108 MAP/MICROTUBULE AFFINITY-REGULATING KINASE BR SERINE_THREONINE KINASE 1 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185244|UniProtKB=T1FMJ8 T1FMJ8 20210047 PTHR11712:SF336 POLYKETIDE SYNTHASE-RELATED 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL transferase activity#GO:0016740;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824 organic acid biosynthetic process#GO:0016053;lipid metabolic process#GO:0006629;oxoacid metabolic process#GO:0043436;monocarboxylic acid biosynthetic process#GO:0072330;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;fatty acid metabolic process#GO:0006631;small molecule biosynthetic process#GO:0044283;cellular lipid metabolic process#GO:0044255;carboxylic acid metabolic process#GO:0019752;small molecule metabolic process#GO:0044281;fatty acid biosynthetic process#GO:0006633;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG172920|UniProtKB=T1F648 T1F648 20204297 PTHR22923:SF116 CEREBELLIN-RELATED C1Q DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG183667|UniProtKB=T1FK05 T1FK05 20209154 PTHR11552:SF147 GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE CHOLINE DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG185880|UniProtKB=T1FNE1 T1FNE1 20210338 PTHR12815:SF18 SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG HELRO|EnsemblGenome=HelroG62030|UniProtKB=T1FWU3 T1FWU3 20213291 PTHR16469:SF27 UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED HELRO|EnsemblGenome=HelroG171517|UniProtKB=T1F4D2 T1F4D2 20203681 PTHR18849:SF8 LEUCINE RICH REPEAT PROTEIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN 61 cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;outer dynein arm assembly#GO:0036158;cell projection organization#GO:0030030;protein-containing complex assembly#GO:0065003;microtubule cytoskeleton organization#GO:0000226;cellular component organization#GO:0016043;axoneme assembly#GO:0035082;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection assembly#GO:0120031 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG102250|UniProtKB=T1ED89 T1ED89 20194541 PTHR13678:SF27 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37 LD45836P cellular localization#GO:0051641;macromolecule localization#GO:0033036;protein targeting to vacuole#GO:0006623;transport#GO:0006810;protein catabolic process#GO:0030163;nitrogen compound transport#GO:0071705;organonitrogen compound catabolic process#GO:1901565;establishment of protein localization#GO:0045184;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;modification-dependent macromolecule catabolic process#GO:0043632;organic substance transport#GO:0071702;establishment of protein localization to membrane#GO:0090150;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein localization to organelle#GO:0033365;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;localization within membrane#GO:0051668;macromolecule catabolic process#GO:0009057;establishment of protein localization to vacuole#GO:0072666;modification-dependent protein catabolic process#GO:0019941;vacuolar transport#GO:0007034;macromolecule metabolic process#GO:0043170;protein localization to membrane#GO:0072657;protein localization to vacuole#GO:0072665;protein targeting#GO:0006605;organonitrogen compound metabolic process#GO:1901564;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein localization#GO:0008104;ubiquitin-dependent protein catabolic process#GO:0006511;localization#GO:0051179;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endosome membrane#GO:0010008;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ESCRT I complex#GO:0000813;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cytoplasmic vesicle membrane#GO:0030659 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG68929|UniProtKB=T1FZM0 T1FZM0 20214268 PTHR21319:SF53 RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1 RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 P53 pathway feedback loops 1#P04392>Pirh-2#P04538;P53 pathway feedback loops 1#P04392>Pirh-2#G04684 HELRO|EnsemblGenome=HelroG185702|UniProtKB=T1FN60 T1FN60 20210258 PTHR24071:SF0 RAN GTPASE GTP-BINDING NUCLEAR PROTEIN RAN GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 cellular component biogenesis#GO:0044085;ribosomal subunit export from nucleus#GO:0000054;cellular localization#GO:0051641;organelle localization#GO:0051640;macromolecule localization#GO:0033036;transport#GO:0006810;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;protein import into nucleus#GO:0006606;cellular macromolecule localization#GO:0070727;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;ribonucleoprotein complex biogenesis#GO:0022613;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;ribosome biogenesis#GO:0042254;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365;establishment of organelle localization#GO:0051656;nuclear transport#GO:0051169;protein-containing complex localization#GO:0031503;import into nucleus#GO:0051170 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG75060|UniProtKB=T1G200 T1G200 20215098 PTHR12668:SF43 TRANSMEMBRANE PROTEIN 14, 15 TRANSMEMBRANE PROTEIN 14 HOMOLOG HELRO|EnsemblGenome=HelroG113547|UniProtKB=T1EFT4 T1EFT4 20195436 PTHR24247:SF267 5-HYDROXYTRYPTAMINE RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;G protein-coupled amine receptor activity#GO:0008227;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;chemical synaptic transmission#GO:0007268;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;synaptic signaling#GO:0099536;trans-synaptic signaling#GO:0099537;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;cell-cell signaling#GO:0007267;signaling#GO:0023052 somatodendritic compartment#GO:0036477;neuron projection#GO:0043005;dendrite#GO:0030425;cell periphery#GO:0071944;dendritic tree#GO:0097447;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG151316|UniProtKB=T1EKJ5 T1EKJ5 20197095 PTHR45751:SF53 COPINE FAMILY PROTEIN 1 VWFA DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG128168|UniProtKB=T1EHL5 T1EHL5 20196065 PTHR23235:SF166 KRUEPPEL-LIKE TRANSCRIPTION FACTOR DENDRITIC ARBOR REDUCTION PROTEIN 1 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG112476|UniProtKB=T1EFK2 T1EFK2 20195354 PTHR46174:SF1 CXXC-TYPE ZINC FINGER PROTEIN 1 CXXC-TYPE ZINC FINGER PROTEIN 1 protein binding#GO:0005515;methylated histone binding#GO:0035064;histone binding#GO:0042393;binding#GO:0005488;modification-dependent protein binding#GO:0140030 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;histone methyltransferase complex#GO:0035097;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;methyltransferase complex#GO:0034708;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513;Set1C/COMPASS complex#GO:0048188 HELRO|EnsemblGenome=HelroG113375|UniProtKB=T1EFS0 T1EFS0 20195422 PTHR10367:SF17 MRNA-CAPPING ENZYME MRNA-CAPPING ENZYME catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mRNA processing#GO:0006397;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 RNA processing factor#PC00147;RNA metabolism protein#PC00031;mRNA capping factor#PC00145 HELRO|EnsemblGenome=HelroG71674|UniProtKB=T1G0Q1 T1G0Q1 20214649 PTHR13410:SF9 PROTEIN PBDC1 PROTEIN PBDC1 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG177581|UniProtKB=T1FBW2 T1FBW2 20206311 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165371|UniProtKB=T1EWN6 T1EWN6 20200986 PTHR33395:SF21 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED PERICARDIN heart morphogenesis#GO:0003007;system development#GO:0048731;heart development#GO:0007507;circulatory system development#GO:0072359;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;animal organ development#GO:0048513;multicellular organism development#GO:0007275;developmental process#GO:0032502;animal organ morphogenesis#GO:0009887;multicellular organismal process#GO:0032501;cell adhesion#GO:0007155;cellular process#GO:0009987;post-embryonic development#GO:0009791 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG84950|UniProtKB=T1G5Q8 T1G5Q8 20216405 PTHR12446:SF34 TESMIN/TSO1-RELATED PROTEIN LIN-54 HOMOLOG regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG176469|UniProtKB=T1FAJ4 T1FAJ4 20205843 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG179132|UniProtKB=T1FE79 T1FE79 20207128 PTHR20956:SF12 HEH2P FLYWCH-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182465|UniProtKB=T1FI86 T1FI86 20208535 PTHR19303:SF71 TRANSPOSON ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG85626|UniProtKB=T1G608 T1G608 20216505 PTHR11064:SF9 CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG163136|UniProtKB=T1ETP7 T1ETP7 20199947 PTHR24034:SF89 EGF-LIKE DOMAIN-CONTAINING PROTEIN COMPLEMENT COMPONENT C1Q RECEPTOR extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG105304|UniProtKB=T1EDT6 T1EDT6 20194738 PTHR43986:SF1 ELONGATION FACTOR 1-GAMMA ELONGATION FACTOR 1-GAMMA macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;translation#GO:0006412;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;translational elongation#GO:0006414;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG93295|UniProtKB=T1G8V0 T1G8V0 20217497 PTHR11588:SF504 TUBULIN TUBULIN BETA-1 CHAIN-RELATED carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;structural molecule activity#GO:0005198;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;structural constituent of cytoskeleton#GO:0005200 cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;microtubule-based process#GO:0007017;organelle organization#GO:0006996;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;cell cycle#GO:0007049;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 tubulin#PC00228;microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Microtubule#P00780;Huntington disease#P00029>beta-Tubulin#P00790;Cytoskeletal regulation by Rho GTPase#P00016>tubulin#P00526 HELRO|EnsemblGenome=HelroG160421|UniProtKB=T1EQ82 T1EQ82 20198732 PTHR11839:SF15 UDP/ADP-SUGAR PYROPHOSPHATASE URIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHATASE NUDT14 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;carbohydrate derivative metabolic process#GO:1901135;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;organophosphate metabolic process#GO:0019637;nucleobase-containing small molecule metabolic process#GO:0055086;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152 pyrophosphatase#PC00196 HELRO|EnsemblGenome=HelroG185417|UniProtKB=T1FMS7 T1FMS7 20210126 PTHR11040:SF140 ZINC/IRON TRANSPORTER ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;transition metal ion transport#GO:0000041;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG182599|UniProtKB=T1FIG0 T1FIG0 20208609 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173199|UniProtKB=T1F6J7 T1F6J7 20204446 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG107643|UniProtKB=T1EEB9 T1EEB9 20194921 PTHR14467:SF0 ARV1 PROTEIN ARV1 sterol metabolic process#GO:0016125;organic hydroxy compound transport#GO:0015850;lipid metabolic process#GO:0006629;cellular localization#GO:0051641;macromolecule localization#GO:0033036;membrane organization#GO:0061024;sterol transport#GO:0015918;plasma membrane organization#GO:0007009;transport#GO:0006810;endomembrane system organization#GO:0010256;lipid transport#GO:0006869;sphingolipid metabolic process#GO:0006665;organic substance transport#GO:0071702;steroid metabolic process#GO:0008202;organic cyclic compound metabolic process#GO:1901360;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;lipid localization#GO:0010876;intracellular lipid transport#GO:0032365;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;organic hydroxy compound metabolic process#GO:1901615;intracellular sterol transport#GO:0032366;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;regulation of membrane lipid distribution#GO:0097035;cellular process#GO:0009987;primary metabolic process#GO:0044238;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;membrane lipid metabolic process#GO:0006643;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular lipid metabolic process#GO:0044255 endoplasmic reticulum tubular network#GO:0071782;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;organelle subcompartment#GO:0031984;cell cortex#GO:0005938;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;cortical endoplasmic reticulum#GO:0032541 HELRO|EnsemblGenome=HelroG185437|UniProtKB=T1FMT8 T1FMT8 20210137 PTHR10366:SF564 NAD DEPENDENT EPIMERASE/DEHYDRATASE STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG149332|UniProtKB=T1EKC7 T1EKC7 20197027 PTHR35249:SF2 DYNEIN REGULATORY COMPLEX SUBUNIT 7 DYNEIN REGULATORY COMPLEX SUBUNIT 7 cell motility#GO:0048870;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;motile cilium#GO:0031514;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cilium#GO:0005929;organelle#GO:0043226 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG185714|UniProtKB=T1FN67 T1FN67 20210265 PTHR10730:SF45 PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG97603|UniProtKB=T1G9I0 T1G9I0 20217727 PTHR24012:SF918 RNA BINDING PROTEIN RRM DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159;mRNA binding#GO:0003729;poly(A) binding#GO:0008143;mRNA 3'-UTR binding#GO:0003730 supramolecular complex#GO:0099080;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein complex#GO:1990904;ribonucleoprotein granule#GO:0035770;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;cytoplasmic stress granule#GO:0010494 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG173479|UniProtKB=T1F6V4 T1F6V4 20204553 PTHR45661:SF3 SURFACE ANTIGEN IG-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191604|UniProtKB=T1FT43 T1FT43 20211990 PTHR22969:SF15 IKB KINASE FI05319P transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;peptidyl-amino acid modification#GO:0018193;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;nitrogen compound metabolic process#GO:0006807;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG160527|UniProtKB=T1EQD0 T1EQD0 20198780 PTHR13217:SF6 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052;Rho protein signal transduction#GO:0007266 HELRO|EnsemblGenome=HelroG176132|UniProtKB=T1FA68 T1FA68 20205717 PTHR24189:SF71 MYOTROPHIN ANKYRIN REPEAT DOMAIN 39 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG180072|UniProtKB=T1FFG0 T1FFG0 20207559 PTHR47385:SF24 CALPONIN MUSCLE-SPECIFIC PROTEIN 20 cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG188358|UniProtKB=T1FPX1 T1FPX1 20210868 PTHR24369:SF210 ANTIGEN BSP, PUTATIVE-RELATED CHAOPTIN-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG169578|UniProtKB=T1F245 T1F245 20202895 PTHR19282:SF534 TETRASPANIN TETRASPANIN FAMILY-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG67265|UniProtKB=T1FYZ0 T1FYZ0 20214038 PTHR21648:SF0 FLAGELLAR RADIAL SPOKE PROTEIN 3 RADIAL SPOKE HEAD PROTEIN 3 HOMOLOG membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cilium#GO:0005929;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025 structural protein#PC00211 HELRO|EnsemblGenome=HelroG185624|UniProtKB=T1FN20 T1FN20 20210219 PTHR19857:SF19 MITOCHONDRIAL DIVISION PROTEIN 1-RELATED 26S PROTEASOME REGULATORY SUBUNIT RPN14 HELRO|EnsemblGenome=HelroG83673|UniProtKB=T1G589 T1G589 20216236 PTHR10159:SF529 DUAL SPECIFICITY PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 regulation of MAPK cascade#GO:0043408;negative regulation of biological process#GO:0048519;macromolecule modification#GO:0043412;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;protein modification process#GO:0036211;regulation of intracellular signal transduction#GO:1902531;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;negative regulation of MAPK cascade#GO:0043409;nitrogen compound metabolic process#GO:0006807;regulation of signal transduction#GO:0009966;protein metabolic process#GO:0019538;negative regulation of cellular process#GO:0048523;negative regulation of cell communication#GO:0010648;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;regulation of cell communication#GO:0010646;negative regulation of response to stimulus#GO:0048585;macromolecule metabolic process#GO:0043170;negative regulation of signaling#GO:0023057;cellular metabolic process#GO:0044237;protein dephosphorylation#GO:0006470;organonitrogen compound metabolic process#GO:1901564;cellular process#GO:0009987;primary metabolic process#GO:0044238;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;dephosphorylation#GO:0016311;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185829|UniProtKB=T1FNC4 T1FNC4 20210321 PTHR19370:SF185 NADH-CYTOCHROME B5 REDUCTASE NADH-CYTOCHROME B5 REDUCTASE nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;flavin adenine dinucleotide binding#GO:0050660;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168 reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG180568|UniProtKB=T1FG20 T1FG20 20207769 PTHR12766:SF7 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DEATH DOMAIN-ASSOCIATED PROTEIN 6 FAS signaling pathway#P00020>DAXX#P00602;Apoptosis signaling pathway#P00006>DAXX#P00296 HELRO|EnsemblGenome=HelroG70455|UniProtKB=T1G067 T1G067 20214465 PTHR23055:SF69 CALCIUM BINDING PROTEINS NEURONAL CALCIUM SENSOR 2 cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG190143|UniProtKB=T1FRQ4 T1FRQ4 20211501 PTHR42884:SF3 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED FURIN-LIKE PROTEASE 1, ISOFORMS 1_1-X_2 hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 bounding membrane of organelle#GO:0098588;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791;Golgi membrane#GO:0000139 serine protease#PC00203;protein modifying enzyme#PC00260 Activin beta signaling pathway#P06210>FUR1#P06238;Endothelin signaling pathway#P00019>furin#P00575;GBB signaling pathway#P06214>FUR1#P06298;SCW signaling pathway#P06216>FUR1#P06333;DPP-SCW signaling pathway#P06212>FUR1#P06263;DPP signaling pathway#P06213>FUR1#P06290;ALP23B signaling pathway#P06209>FUR1#P06227;Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105;BMP/activin signaling pathway-drosophila#P06211>Furin#P06244;Alzheimer disease-presenilin pathway#P00004>Furin#P00157;MYO signaling pathway#P06215>FUR1#P06318 HELRO|EnsemblGenome=HelroG100509|UniProtKB=T1ED00 T1ED00 20194452 PTHR11685:SF212 RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE ARIH1 ubiquitin-like protein conjugating enzyme binding#GO:0044390;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;enzyme binding#GO:0019899;protein binding#GO:0005515;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG62273|UniProtKB=T1FWY3 T1FWY3 20213331 PTHR10807:SF75 MYOTUBULARIN-RELATED PHOSPHATIDYLINOSITOL-3-PHOSPHATE PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase binding#GO:0019902;phosphatase activity#GO:0016791;binding#GO:0005488;catalytic activity#GO:0003824;phosphatidylinositol-3,5-bisphosphate phosphatase activity#GO:0106018;hydrolase activity#GO:0016787;enzyme binding#GO:0019899;protein binding#GO:0005515;protein phosphatase binding#GO:0019903;phosphoric ester hydrolase activity#GO:0042578 phospholipid dephosphorylation#GO:0046839;lipid metabolic process#GO:0006629;regulation of catabolic process#GO:0009894;phosphatidylinositol dephosphorylation#GO:0046856;regulation of autophagy#GO:0010506;cellular metabolic process#GO:0044237;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;regulation of cellular catabolic process#GO:0031329;lipid modification#GO:0030258;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;glycerolipid metabolic process#GO:0046486;regulation of cellular process#GO:0050794;dephosphorylation#GO:0016311;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;regulation of metabolic process#GO:0019222;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG192051|UniProtKB=T1FTJ6 T1FTJ6 20212143 PTHR13269:SF6 NUCLEOPORIN NDC1 NUCLEOPORIN NDC1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 nucleus organization#GO:0006997;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cellular process#GO:0009987;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933 envelope#GO:0031975;nuclear pore#GO:0005643;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG186065|UniProtKB=T1FNM2 T1FNM2 20210419 PTHR11843:SF0 40S RIBOSOMAL PROTEIN S12 SMALL RIBOSOMAL SUBUNIT PROTEIN ES12 cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;translation#GO:0006412;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;cellular component organization or biogenesis#GO:0071840;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;ribosomal small subunit biogenesis#GO:0042274;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG144922|UniProtKB=T1EJH1 T1EJH1 20196721 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG185118|UniProtKB=T1FMF1 T1FMF1 20210000 PTHR22599:SF8 MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB MOB KINASE ACTIVATOR-LIKE 1 protein kinase activator activity#GO:0030295;protein kinase regulator activity#GO:0019887;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234;kinase activator activity#GO:0019209 positive regulation of nitrogen compound metabolic process#GO:0051173;signal transduction#GO:0007165;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;positive regulation of protein modification process#GO:0031401;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of metabolic process#GO:0009893;positive regulation of biological process#GO:0048518;signaling#GO:0023052;positive regulation of protein phosphorylation#GO:0001934;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;positive regulation of protein metabolic process#GO:0051247;positive regulation of phosphate metabolic process#GO:0045937;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of protein phosphorylation#GO:0001932;biological regulation#GO:0065007;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 kinase modulator#PC00140;kinase activator#PC00138 HELRO|EnsemblGenome=HelroG64289|UniProtKB=T1FXS3 T1FXS3 20213621 PTHR12303:SF6 CARNOSINE N-METHYLTRANSFERASE CARNOSINE N-METHYLTRANSFERASE methyltransferase activity#GO:0008168;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757 HELRO|EnsemblGenome=HelroG162304|UniProtKB=T1ESH3 T1ESH3 20199523 PTHR19282:SF560 TETRASPANIN BRCT DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185008|UniProtKB=T1FM98 T1FM98 20209947 PTHR13976:SF76 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED AT27789P ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG62698|UniProtKB=T1FX38 T1FX38 20213386 PTHR13780:SF35 AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT LD22662P kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG174473|UniProtKB=T1F858 T1F858 20205007 PTHR11905:SF247 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG111897|UniProtKB=T1EFF5 T1EFF5 20195307 PTHR10901:SF6 TROPOMODULIN TROPOMODULIN, ISOFORM N cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;binding#GO:0005488 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG189815|UniProtKB=T1FRE1 T1FRE1 20211388 PTHR12766:SF7 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DEATH DOMAIN-ASSOCIATED PROTEIN 6 FAS signaling pathway#P00020>DAXX#P00602;Apoptosis signaling pathway#P00006>DAXX#P00296 HELRO|EnsemblGenome=HelroG194218|UniProtKB=T1FVT6 T1FVT6 20212932 PTHR23404:SF3 MOLYBDOPTERIN SYNTHASE RELATED MAP3K12-BINDING INHIBITORY PROTEIN 1 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG66303|UniProtKB=T1FYJ5 T1FYJ5 20213893 PTHR43215:SF14 RADIAL SPOKE HEAD 1 HOMOLOG RADIAL SPOKE HEAD 1 HOMOLOG HELRO|EnsemblGenome=HelroG164869|UniProtKB=T1EVW5 T1EVW5 20200715 PTHR46513:SF13 VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG165520|UniProtKB=T1EWY7 T1EWY7 20201087 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG179880|UniProtKB=T1FF81 T1FF81 20207480 PTHR37153:SF1 CHROMOSOME 19 C19ORF81 HOMOLOG HYPOTHETICAL LOC292874 HELRO|EnsemblGenome=HelroG167104|UniProtKB=T1EZ09 T1EZ09 20201809 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG160608|UniProtKB=T1EQH5 T1EQH5 20198825 PTHR45640:SF26 HEAT SHOCK PROTEIN HSP-12.2-RELATED RE23625P chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HELRO|EnsemblGenome=HelroG77640|UniProtKB=T1G314 T1G314 20215462 PTHR11562:SF17 CATION EFFLUX PROTEIN/ ZINC TRANSPORTER RE54080P-RELATED inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;transition metal ion transport#GO:0000041;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG187538|UniProtKB=T1FPA6 T1FPA6 20210653 PTHR10644:SF3 DNA REPAIR/RNA PROCESSING CPSF FAMILY DNA DAMAGE-BINDING PROTEIN 1 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG174796|UniProtKB=T1F8H4 T1F8H4 20205123 PTHR47537:SF2 CUBILIN CUBILIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG190613|UniProtKB=T1FS49 T1FS49 20211646 PTHR24205:SF4 FOUR AND A HALF LIM DOMAINS PROTEIN PROTEIN ESPINAS molecular adaptor activity#GO:0060090;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;protein-macromolecule adaptor activity#GO:0030674 supramolecular complex#GO:0099080;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;Z disc#GO:0030018;cellular anatomical entity#GO:0110165;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;contractile fiber#GO:0043292;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;sarcomere#GO:0030017;membrane-bounded organelle#GO:0043227;myofibril#GO:0030016;I band#GO:0031674 transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG76891|UniProtKB=T1G2Q5 T1G2Q5 20215353 PTHR21016:SF1 BETA-AMYLOID BINDING PROTEIN-RELATED TM2 DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG103978|UniProtKB=T1EDJ0 T1EDJ0 20194642 PTHR44366:SF1 UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT acetylglucosaminyltransferase activity#GO:0008375;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG193976|UniProtKB=T1FVJ0 T1FVJ0 20212836 PTHR47765:SF2 3'-5' EXONUCLEASE DOMAIN-CONTAINING PROTEIN EXONUCLEASE MUT-7 HOMOLOG HELRO|EnsemblGenome=HelroG138774|UniProtKB=T1EIX7 T1EIX7 20196527 PTHR10083:SF381 KUNITZ-TYPE PROTEASE INHIBITOR-RELATED BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN peptidase inhibitor activity#GO:0030414;molecular function regulator activity#GO:0098772;serine-type endopeptidase inhibitor activity#GO:0004867;peptidase regulator activity#GO:0061134;enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;endopeptidase regulator activity#GO:0061135;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG109933|UniProtKB=T1EEX5 T1EEX5 20195127 PTHR48036:SF6 SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED RNA BINDING MOTIF PROTEIN 39B ISOFORM X1-RELATED ribonucleoprotein complex binding#GO:0043021;protein-containing complex binding#GO:0044877;binding#GO:0005488 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG187817|UniProtKB=T1FPE4 T1FPE4 20210691 PTHR23275:SF100 CABRIOLET.-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG96872|UniProtKB=T1G9E0 T1G9E0 20217687 PTHR24351:SF110 RIBOSOMAL PROTEIN S6 KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;nitrogen compound metabolic process#GO:0006807;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 Interleukin signaling pathway#P00036>p90RSK#P00964;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>P90 RSK#P00888;PDGF signaling pathway#P00047>p90RSK#P01142 HELRO|EnsemblGenome=HelroG94914|UniProtKB=T1G938 T1G938 20217585 PTHR10671:SF82 EPITHELIAL MEMBRANE PROTEIN-RELATED GH19567P cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG88096|UniProtKB=T1G6Y5 T1G6Y5 20216832 PTHR21646:SF23 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE USP2 cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG116136|UniProtKB=T1EGD2 T1EGD2 20195634 PTHR12346:SF0 SIN3B-RELATED SIN3A, ISOFORM G molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;protein-macromolecule adaptor activity#GO:0030674 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;histone deacetylase complex#GO:0000118;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077 Huntington disease#P00029>Sin3A#P00771 HELRO|EnsemblGenome=HelroG156844|UniProtKB=T1EM18 T1EM18 20197618 PTHR10642:SF26 RIBONUCLEASE H1 RIBONUCLEASE H1 catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular nitrogen compound catabolic process#GO:0044270;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic cyclic compound catabolic process#GO:1901361;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;organic substance catabolic process#GO:1901575;nucleobase-containing compound catabolic process#GO:0034655;DNA replication#GO:0006260;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;cellular catabolic process#GO:0044248 endoribonuclease#PC00094;RNA metabolism protein#PC00031 DNA replication#P00017>RNase H#P00538 HELRO|EnsemblGenome=HelroG94192|UniProtKB=T1G8Z2 T1G8Z2 20217539 PTHR45832:SF8 SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185000|UniProtKB=T1FM92 T1FM92 20209941 PTHR21308:SF1 PHYTANOYL-COA ALPHA-HYDROXYLASE PHYTANOYL-COA DIOXYGENASE, PEROXISOMAL hydroxylase#PC00122 HELRO|EnsemblGenome=HelroG158382|UniProtKB=T1EMQ7 T1EMQ7 20197857 PTHR45973:SF12 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED DYNEIN REGULATORY COMPLEX SUBUNIT 3 membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cilium#GO:0005929;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG66421|UniProtKB=T1FYK9 T1FYK9 20213907 PTHR10896:SF65 GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE BETA-1,3-GLUCURONYLTRANSFERASE GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE 3 carbohydrate metabolic process#GO:0005975;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG172077|UniProtKB=T1F502 T1F502 20203901 PTHR22741:SF10 P140CAP/SNIP-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG125222|UniProtKB=T1EH51 T1EH51 20195901 PTHR11232:SF57 PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER RE46159P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG63277|UniProtKB=T1FXD5 T1FXD5 20213483 PTHR11309:SF47 FRIZZLED FRIZZLED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;protein binding#GO:0005515;Wnt-protein binding#GO:0017147;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;non-canonical Wnt signaling pathway#GO:0035567;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;cell-cell signaling by wnt#GO:0198738;canonical Wnt signaling pathway#GO:0060070;cell-cell signaling#GO:0007267;signaling#GO:0023052;Wnt signaling pathway#GO:0016055 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Angiogenesis#P00005>Fzd#P00189;Wnt signaling pathway#P00057>Frizzled#P01428;Alzheimer disease-presenilin pathway#P00004>Frizzled#P00119;Cadherin signaling pathway#P00012>Frizzled#P00475 HELRO|EnsemblGenome=HelroG174234|UniProtKB=T1F7U5 T1F7U5 20204894 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG70559|UniProtKB=T1G085 T1G085 20214483 PTHR12262:SF0 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of protein metabolic process#GO:0051246;negative regulation of biosynthetic process#GO:0009890;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of translation#GO:0017148;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;protein-containing complex#GO:0032991;P-body#GO:0000932;CCR4-NOT complex#GO:0030014;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic ribonucleoprotein granule#GO:0036464 HELRO|EnsemblGenome=HelroG134516|UniProtKB=T1EI51 T1EI51 20196251 PTHR11462:SF35 JUN TRANSCRIPTION FACTOR-RELATED TRANSCRIPTION FACTOR JRA sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667 DNA-binding transcription factor#PC00218;basic leucine zipper transcription factor#PC00056 TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>AP-1#P00838 HELRO|EnsemblGenome=HelroG167043|UniProtKB=T1EYX9 T1EYX9 20201779 PTHR46880:SF5 RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG72389|UniProtKB=T1G0Z4 T1G0Z4 20214742 PTHR15427:SF33 EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG172979|UniProtKB=T1F686 T1F686 20204335 PTHR10773:SF19 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2 SUBFAMILY NOT NAMED RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG161080|UniProtKB=T1ER29 T1ER29 20199029 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG81152|UniProtKB=T1G4A3 T1G4A3 20215901 PTHR14085:SF3 WD-REPEAT PROTEIN BING4 WD REPEAT-CONTAINING PROTEIN 46 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981;90S preribosome#GO:0030686 HELRO|EnsemblGenome=HelroG84874|UniProtKB=T1G5P9 T1G5P9 20216396 PTHR11945:SF23 MADS BOX PROTEIN MYOCYTE-SPECIFIC ENHANCER FACTOR 2D sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;cell differentiation#GO:0030154;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 MADS box transcription factor#PC00250 CCKR signaling map#P06959>MEF2D#P07048;p38 MAPK pathway#P05918>MEF#P06023;CCKR signaling map#P06959>MEF2#P07032 HELRO|EnsemblGenome=HelroG194947|UniProtKB=T1FWL6 T1FWL6 20213211 PTHR10634:SF149 AN1-TYPE ZINC FINGER PROTEIN AN1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG174987|UniProtKB=T1F8P5 T1F8P5 20205194 PTHR45834:SF3 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9-RELATED RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 3, ISOFORM L nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG140913|UniProtKB=T1EJ20 T1EJ20 20196570 PTHR24044:SF502 NOTCH LIGAND FAMILY MEMBER ANTERIOR PHARYNX IN EXCESS PROTEIN 1-RELATED protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG109312|UniProtKB=T1EES3 T1EES3 20195075 PTHR46212:SF9 PEFLIN PROGRAMMED CELL DEATH PROTEIN 6 HELRO|EnsemblGenome=HelroG89696|UniProtKB=T1G7G1 T1G7G1 20217008 PTHR48013:SF11 DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED LICORNE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;MAPK cascade#GO:0000165;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 FGF signaling pathway#P00021>MKK3,6#P00625;EGF receptor signaling pathway#P00018>MKK3,6#P00540;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>MEK#P00891 HELRO|EnsemblGenome=HelroG180314|UniProtKB=T1FFQ3 T1FFQ3 20207652 PTHR31034:SF2 TRANSMEMBRANE PROTEIN 101 TRANSMEMBRANE PROTEIN 101 positive regulation of canonical NF-kappaB signal transduction#GO:0043123;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;regulation of cellular process#GO:0050794;regulation of canonical NF-kappaB signal transduction#GO:0043122;regulation of signal transduction#GO:0009966;positive regulation of cell communication#GO:0010647;biological regulation#GO:0065007;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518 HELRO|EnsemblGenome=HelroG69178|UniProtKB=T1FZQ6 T1FZQ6 20214304 PTHR12995:SF4 FI21814P1 FI21814P1 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG157319|UniProtKB=T1EM96 T1EM96 20197696 PTHR24256:SF470 TRYPTASE-RELATED INACTIVE CLIP DOMAIN-CONTAINING SERINE PROTEASE A30 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191034|UniProtKB=T1FSI8 T1FSI8 20211785 PTHR10027:SF33 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic ion-gated channel activity#GO:0022839;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium-activated cation channel activity#GO:0005227;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG72409|UniProtKB=T1G0Z5 T1G0Z5 20214743 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;heme binding#GO:0020037 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG192222|UniProtKB=T1FTQ5 T1FTQ5 20212202 PTHR21027:SF1 TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54 TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;tRNA splicing, via endonucleolytic cleavage and ligation#GO:0006388;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 protein-containing complex#GO:0032991;endoribonuclease complex#GO:1902555;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;endonuclease complex#GO:1905348;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG184512|UniProtKB=T1FLD1 T1FLD1 20209630 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG161501|UniProtKB=T1ERK2 T1ERK2 20199202 PTHR46480:SF1 F20B24.22 VOLTAGE-GATED HYDROGEN CHANNEL 1 monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;voltage-gated channel activity#GO:0022832;proton channel activity#GO:0015252;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;proton transmembrane transport#GO:1902600;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG157165|UniProtKB=T1EM74 T1EM74 20197674 PTHR19134:SF542 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE S hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 cellular component organization or biogenesis#GO:0071840;synapse organization#GO:0050808;cell junction organization#GO:0034330;cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;synaptic membrane adhesion#GO:0099560;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cellular process#GO:0009987 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG183644|UniProtKB=T1FJZ5 T1FJZ5 20209144 PTHR18945:SF865 NEUROTRANSMITTER GATED ION CHANNEL NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA7, ISOFORM E ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG110470|UniProtKB=T1EF24 T1EF24 20195176 PTHR11908:SF132 XANTHINE DEHYDROGENASE ALDEHYDE OXIDASE 1-RELATED oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 oxidoreductase#PC00176 Adenine and hypoxanthine salvage pathway#P02723>Xanthine dehydrogenase#P02809;Purine metabolism#P02769>Xanthine Oxidase#P03116 HELRO|EnsemblGenome=HelroG182705|UniProtKB=T1FIM0 T1FIM0 20208669 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185950|UniProtKB=T1FNH2 T1FNH2 20210369 PTHR10476:SF17 CHARGED MULTIVESICULAR BODY PROTEIN CHARGED MULTIVESICULAR BODY PROTEIN 1A endosomal transport#GO:0016197;cellular localization#GO:0051641;macromolecule localization#GO:0033036;vacuolar transport#GO:0007034;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;late endosome to vacuole transport#GO:0045324;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;endosome transport via multivesicular body sorting pathway#GO:0032509;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endosome membrane#GO:0010008;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG74648|UniProtKB=T1G1T6 T1G1T6 20215034 PTHR24056:SF171 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 20 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG170760|UniProtKB=T1F3E1 T1F3E1 20203340 PTHR21399:SF0 CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN METHYLOSOME SUBUNIT PICLN cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;mRNA cis splicing, via spliceosome#GO:0045292;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;spliceosomal snRNP assembly#GO:0000387;organic substance metabolic process#GO:0071704;mRNA splicing, via spliceosome#GO:0000398;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;pICln-Sm protein complex#GO:0034715;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;Sm-like protein family complex#GO:0120114;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG145315|UniProtKB=T1EJK0 T1EJK0 20196750 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG168546|UniProtKB=T1F0P7 T1F0P7 20202397 PTHR21437:SF1 WIDE AWAKE WIDE AWAKE HELRO|EnsemblGenome=HelroG170818|UniProtKB=T1F3G8 T1F3G8 20203367 PTHR38636:SF1 PROTEIN CBG20488 CHLORIDE CHANNEL PROTEIN CLC-D HELRO|EnsemblGenome=HelroG81872|UniProtKB=T1G4K0 T1G4K0 20215998 PTHR24346:SF79 MAP/MICROTUBULE AFFINITY-REGULATING KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG176575|UniProtKB=T1FAP0 T1FAP0 20205889 PTHR12147:SF22 METALLOPEPTIDASE M28 FAMILY MEMBER ENDOPLASMIC RETICULUM METALLOPEPTIDASE 1 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;metabolic process#GO:0008152;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG184726|UniProtKB=T1FLV4 T1FLV4 20209803 PTHR10722:SF0 60S RIBOSOMAL PROTEIN L19 RIBOSOMAL PROTEIN L19 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG171098|UniProtKB=T1F3T2 T1F3T2 20203481 PTHR12287:SF23 EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN AROUSER, ISOFORM A-RELATED cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;actin binding#GO:0003779;binding#GO:0005488 regulation of cell communication#GO:0010646;regulation of Rho protein signal transduction#GO:0035023;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;small GTPase-mediated signal transduction#GO:0007264;regulation of signaling#GO:0023051;cell communication#GO:0007154;cellular process#GO:0009987;regulation of intracellular signal transduction#GO:1902531;Rho protein signal transduction#GO:0007266;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;intracellular signal transduction#GO:0035556;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG63467|UniProtKB=T1FXG2 T1FXG2 20213510 PTHR45815:SF3 PROTEIN DISULFIDE-ISOMERASE A6 PROTEIN DISULFIDE-ISOMERASE A6 protein-disulfide reductase activity#GO:0015035;disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;response to stress#GO:0006950;response to endoplasmic reticulum stress#GO:0034976;cellular process#GO:0009987;cellular response to stress#GO:0033554 membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;organelle lumen#GO:0043233;endoplasmic reticulum lumen#GO:0005788;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG63613|UniProtKB=T1FXI3 T1FXI3 20213531 PTHR10682:SF10 POLY A POLYMERASE POLYNUCLEOTIDE ADENYLYLTRANSFERASE adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;mRNA polyadenylation#GO:0006378;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;mRNA 3'-end processing#GO:0031124;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mRNA processing#GO:0006397;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG183749|UniProtKB=T1FK50 T1FK50 20209199 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188930|UniProtKB=T1FQH7 T1FQH7 20211074 PTHR31057:SF0 E3 UFM1-PROTEIN LIGASE 1 E3 UFM1-PROTEIN LIGASE 1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824 regulation of protein metabolic process#GO:0051246;regulation of catabolic process#GO:0009894;macromolecule modification#GO:0043412;regulation of nitrogen compound metabolic process#GO:0051171;protein modification process#GO:0036211;regulation of protein catabolic process#GO:0042176;regulation of proteolysis involved in protein catabolic process#GO:1903050;post-translational protein modification#GO:0043687;regulation of biological process#GO:0050789;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;regulation of proteolysis#GO:0030162;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;protein modification by small protein conjugation or removal#GO:0070647;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;cellular process#GO:0009987;primary metabolic process#GO:0044238;regulation of primary metabolic process#GO:0080090;regulation of proteasomal protein catabolic process#GO:0061136;response to stimulus#GO:0050896;response to stress#GO:0006950;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;cellular response to stress#GO:0033554;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;regulation of metabolic process#GO:0019222 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG114917|UniProtKB=T1EG54 T1EG54 20195556 PTHR12203:SF122 KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;glucosyltransferase activity#GO:0046527;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758 cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG183412|UniProtKB=T1FJL4 T1FJL4 20209014 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG72376|UniProtKB=T1G0Z1 T1G0Z1 20214739 PTHR20856:SF7 DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;RNA polymerase activity#GO:0097747;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG67216|UniProtKB=T1FYY2 T1FYY2 20214030 PTHR19849:SF0 PHOSPHOLIPASE A-2-ACTIVATING PROTEIN PHOSPHOLIPASE A-2-ACTIVATING PROTEIN protein binding#GO:0005515;ubiquitin-like protein binding#GO:0032182;binding#GO:0005488;ubiquitin binding#GO:0043130 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;homeostatic process#GO:0042592;cellular homeostasis#GO:0019725;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG110043|UniProtKB=T1EEY6 T1EEY6 20195138 PTHR13274:SF2 MITOCHONDRIAL RIBOSOMAL PROTEIN S25 SMALL RIBOSOMAL SUBUNIT PROTEIN MS25 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG68930|UniProtKB=T1FZM1 T1FZM1 20214269 PTHR13357:SF1 SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN NCK-INTERACTING PROTEIN WITH SH3 DOMAIN protein-containing complex binding#GO:0044877;binding#GO:0005488 localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;cellular process#GO:0009987;import into cell#GO:0098657;endocytosis#GO:0006897;transport#GO:0006810 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG72329|UniProtKB=T1G0Y4 T1G0Y4 20214732 PTHR19297:SF191 GLYCOSYLTRANSFERASE 14 FAMILY MEMBER PROTEIN XYLOSYLTRANSFERASE acetylglucosaminyltransferase activity#GO:0008375;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG190775|UniProtKB=T1FSA3 T1FSA3 20211700 PTHR14352:SF2 HAUS AUGMIN-LIKE COMPLEX SUBUNIT 7 HAUS AUGMIN-LIKE COMPLEX SUBUNIT 7 cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule organizing center organization#GO:0031023;chromosome segregation#GO:0007059;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;spindle assembly#GO:0051225;cytoskeleton organization#GO:0007010;cell cycle#GO:0007049;spindle organization#GO:0007051;non-membrane-bounded organelle assembly#GO:0140694 intracellular non-membrane-bounded organelle#GO:0043232;microtubule associated complex#GO:0005875;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;HAUS complex#GO:0070652;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG169268|UniProtKB=T1F1P0 T1F1P0 20202740 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG190746|UniProtKB=T1FS93 T1FS93 20211690 PTHR24104:SF47 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED E3 UBIQUITIN-PROTEIN LIGASE NHLRC1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG194641|UniProtKB=T1FW97 T1FW97 20213093 PTHR12269:SF1 EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TRANSPORTER EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TRANSPORTER transporter#PC00227 HELRO|EnsemblGenome=HelroG171179|UniProtKB=T1F3W6 T1F3W6 20203515 PTHR35081:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 105 COILED-COIL DOMAIN-CONTAINING PROTEIN 105 HELRO|EnsemblGenome=HelroG176988|UniProtKB=T1FB36 T1FB36 20206035 PTHR21041:SF17 DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN E3 UBIQUITIN-PROTEIN LIGASE DCST1 HELRO|EnsemblGenome=HelroG178084|UniProtKB=T1FCP6 T1FCP6 20206595 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cell communication#GO:0007154;cellular process#GO:0009987;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;Notch signaling pathway#GO:0007219 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG76712|UniProtKB=T1G2N1 T1G2N1 20215329 PTHR12703:SF4 TRANSMEMBRANE PROTEIN 33 TRANSMEMBRANE PROTEIN 33 cellular component organization or biogenesis#GO:0071840;endoplasmic reticulum organization#GO:0007029;endoplasmic reticulum tubular network organization#GO:0071786;membrane organization#GO:0061024;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;cellular component organization#GO:0016043;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG188150|UniProtKB=T1FPP8 T1FPP8 20210795 PTHR11208:SF45 RNA-BINDING PROTEIN RELATED SPLICING FACTOR 1 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of RNA splicing#GO:0043484;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of mRNA processing#GO:0050684;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;regulation of mRNA metabolic process#GO:1903311 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG72990|UniProtKB=T1G184 T1G184 20214832 PTHR11727:SF7 DIMETHYLADENOSINE TRANSFERASE DIMETHYLADENOSINE TRANSFERASE-RELATED catalytic activity, acting on RNA#GO:0140098;N-methyltransferase activity#GO:0008170;transferase activity#GO:0016740;rRNA (adenine) methyltransferase activity#GO:0016433;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on a rRNA#GO:0140102;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;rRNA methyltransferase activity#GO:0008649;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;RNA methyltransferase activity#GO:0008173 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA modification#GO:0009451;rRNA modification#GO:0000154;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;ribosome biogenesis#GO:0042254;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;rRNA methylation#GO:0031167;nucleic acid metabolic process#GO:0090304;methylation#GO:0032259;macromolecule methylation#GO:0043414;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;RNA methylation#GO:0001510 RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG175671|UniProtKB=T1F9I2 T1F9I2 20205481 PTHR10166:SF66 VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED VWFA AND CACHE DOMAIN-CONTAINING PROTEIN CG16868 calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated calcium channel activity#GO:0005245;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 voltage-gated calcium channel complex#GO:0005891;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;calcium channel complex#GO:0034704;membrane#GO:0016020;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG177421|UniProtKB=T1FBN7 T1FBN7 20206236 PTHR11977:SF130 VILLIN SEVERIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;actin polymerization or depolymerization#GO:0008154;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG62927|UniProtKB=T1FX79 T1FX79 20213427 PTHR45892:SF1 AMINOACYLASE-1 AMINOACYLASE-1 hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG108466|UniProtKB=T1EEJ3 T1EEJ3 20194995 PTHR11504:SF0 CYTOCHROME C OXIDASE POLYPEPTIDE VIA CYTOCHROME C OXIDASE SUBUNIT enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 mitochondrial ATP synthesis coupled electron transport#GO:0042775;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;respiratory electron transport chain#GO:0022904;generation of precursor metabolites and energy#GO:0006091;aerobic electron transport chain#GO:0019646;oxidative phosphorylation#GO:0006119;electron transport chain#GO:0022900;ATP synthesis coupled electron transport#GO:0042773;cellular metabolic process#GO:0044237;cellular process#GO:0009987;mitochondrial electron transport, cytochrome c to oxygen#GO:0006123;energy derivation by oxidation of organic compounds#GO:0015980;metabolic process#GO:0008152 oxidase#PC00175;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG182232|UniProtKB=T1FHY9 T1FHY9 20208438 PTHR31606:SF1 WW DOMAIN BINDING PROTEIN 2, ISOFORM E WW DOMAIN BINDING PROTEIN 2, ISOFORM E molecular adaptor activity#GO:0060090;nucleic acid binding#GO:0003676;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;chromatin DNA binding#GO:0031490;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;protein-macromolecule adaptor activity#GO:0030674;DNA binding#GO:0003677;transcription coactivator activity#GO:0003713;protein-containing complex binding#GO:0044877 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG103696|UniProtKB=T1EDG8 T1EDG8 20194620 PTHR43671:SF13 SERINE/THREONINE-PROTEIN KINASE NEK SERINE_THREONINE-PROTEIN KINASE NEK2 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG178970|UniProtKB=T1FDZ6 T1FDZ6 20207045 PTHR18861:SF0 ELKS/RAB6-INTERACTING/CAST PROTEIN BRUCHPILOT, ISOFORM J membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG185346|UniProtKB=T1FMP8 T1FMP8 20210097 PTHR28525:SF1 REACTIVE OXYGEN SPECIES MODULATOR 1 REACTIVE OXYGEN SPECIES MODULATOR 1 cellular localization#GO:0051641;protein insertion into mitochondrial inner membrane#GO:0045039;macromolecule localization#GO:0033036;membrane organization#GO:0061024;transport#GO:0006810;protein transmembrane transport#GO:0071806;nitrogen compound transport#GO:0071705;protein transmembrane import into intracellular organelle#GO:0044743;establishment of protein localization#GO:0045184;organic substance transport#GO:0071702;establishment of protein localization to membrane#GO:0090150;establishment of localization#GO:0051234;protein targeting to mitochondrion#GO:0006626;mitochondrion organization#GO:0007005;protein localization to organelle#GO:0033365;mitochondrial transmembrane transport#GO:1990542;localization within membrane#GO:0051668;transmembrane transport#GO:0055085;protein localization to membrane#GO:0072657;protein targeting#GO:0006605;establishment of protein localization to organelle#GO:0072594;cellular component organization#GO:0016043;cellular process#GO:0009987;protein localization to mitochondrion#GO:0070585;protein localization#GO:0008104;inner mitochondrial membrane organization#GO:0007007;localization#GO:0051179;mitochondrial transport#GO:0006839;cellular component organization or biogenesis#GO:0071840;protein import into mitochondrial matrix#GO:0030150;cellular macromolecule localization#GO:0070727;establishment of protein localization to mitochondrion#GO:0072655;organelle organization#GO:0006996;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;mitochondrial membrane organization#GO:0007006 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;TIM23 mitochondrial import inner membrane translocase complex#GO:0005744;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;mitochondrial protein-containing complex#GO:0098798 HELRO|EnsemblGenome=HelroG185478|UniProtKB=T1FMV5 T1FMV5 20210154 PTHR19431:SF0 60S RIBOSOMAL PROTEIN L4 LARGE RIBOSOMAL SUBUNIT PROTEIN UL4 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG116401|UniProtKB=T1EGE5 T1EGE5 20195647 PTHR13140:SF729 MYOSIN UNCONVENTIONAL MYOSIN-IE microfilament motor activity#GO:0000146;cytoskeletal protein binding#GO:0008092;ATP-dependent activity#GO:0140657;binding#GO:0005488;actin filament binding#GO:0051015;cytoskeletal motor activity#GO:0003774;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779 localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;establishment of localization#GO:0051234;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;transport#GO:0006810;endocytosis#GO:0006897;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;import into cell#GO:0098657 microvillus#GO:0005902;actin-based cell projection#GO:0098858;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cell projection#GO:0042995;plasma membrane#GO:0005886 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG152153|UniProtKB=T1EKP9 T1EKP9 20197149 PTHR45255:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 24 DNAJ HOMOLOG SUBFAMILY C MEMBER 24 cation binding#GO:0043169;molecular function activator activity#GO:0140677;ferrous iron binding#GO:0008198;small molecule binding#GO:0036094;molecular function regulator activity#GO:0098772;binding#GO:0005488;iron ion binding#GO:0005506;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;ATPase activator activity#GO:0001671;ion binding#GO:0043167 biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of molecular function#GO:0065009 chaperone#PC00072 HELRO|EnsemblGenome=HelroG78384|UniProtKB=T1G3B3 T1G3B3 20215561 PTHR24416:SF580 TYROSINE-PROTEIN KINASE RECEPTOR DISCOIDIN DOMAIN RECEPTOR, ISOFORM F signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888;transferase activity#GO:0016740;transmembrane receptor protein kinase activity#GO:0019199;collagen binding#GO:0005518;molecular transducer activity#GO:0060089;protein-containing complex binding#GO:0044877;catalytic activity, acting on a protein#GO:0140096 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;regulation of cellular component organization#GO:0051128;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;regulation of plasma membrane bounded cell projection organization#GO:0120035;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;regulation of neuron projection development#GO:0010975;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;anatomical structure development#GO:0048856;regulation of cell projection organization#GO:0031344;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG135232|UniProtKB=T1EI77 T1EI77 20196277 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG172030|UniProtKB=T1F4Y8 T1F4Y8 20203887 PTHR20338:SF7 NUCLEAR RESPIRATORY FACTOR 1 MISEXPRESSION SUPPRESSOR OF RAS 3, ISOFORM B sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG188448|UniProtKB=T1FPZ9 T1FPZ9 20210896 PTHR19321:SF41 PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED FASCETTO-RELATED cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule-based process#GO:0007017;organelle organization#GO:0006996 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;spindle#GO:0005819;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG110527|UniProtKB=T1EF31 T1EF31 20195183 PTHR24250:SF67 CHYMOTRYPSIN-RELATED PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG77335|UniProtKB=T1G2W3 T1G2W3 20215411 PTHR45750:SF3 GH11602P HISTONE ACETYLTRANSFERASE histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;transferase activity#GO:0016740;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 positive regulation of nitrogen compound metabolic process#GO:0051173;protein-DNA complex organization#GO:0071824;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;regulation of DNA-templated transcription#GO:0006355;cellular component organization#GO:0016043;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;chromatin organization#GO:0006325;positive regulation of RNA metabolic process#GO:0051254;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;chromatin#GO:0000785;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;chromosome#GO:0005694 Notch signaling pathway#P00045>CoA#P01100 HELRO|EnsemblGenome=HelroG63547|UniProtKB=T1FXH2 T1FXH2 20213520 PTHR15852:SF54 PLASTID TRANSCRIPTIONALLY ACTIVE PROTEIN PROTEIN SSUH2 HOMOLOG HELRO|EnsemblGenome=HelroG120427|UniProtKB=T1EGP9 T1EGP9 20195749 PTHR13906:SF4 PORCUPINE LYSOPHOSPHOLIPID ACYLTRANSFERASE 6 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;cellular metabolic process#GO:0044237;lipid modification#GO:0030258;cellular lipid metabolic process#GO:0044255;cellular process#GO:0009987;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transferase#PC00220;acetyltransferase#PC00038;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG87607|UniProtKB=T1G6S9 T1G6S9 20216776 PTHR23506:SF23 GH10249P GH10249P secondary carrier transporter#PC00258;transporter#PC00227 Adrenaline and noradrenaline biosynthesis#P00001>VAT1#P00071;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>VAChT#P01078;5HT3 type receptor mediated signaling pathway#P04375>5HT vesicular transporter#P04424;5HT2 type receptor mediated signaling pathway#P04374>5HT vesicular transporter#P04418;Nicotinic acetylcholine receptor signaling pathway#P00044>VAChT#P01089;5HT4 type receptor mediated signaling pathway#P04376>5HT vesicular transporter#P04432;5HT1 type receptor mediated signaling pathway#P04373>5HT vesicular transporter#P04410 HELRO|EnsemblGenome=HelroG188517|UniProtKB=T1FQ31 T1FQ31 20210928 PTHR19282:SF551 TETRASPANIN RE08073P-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG193651|UniProtKB=T1FV81 T1FV81 20212727 PTHR21219:SF3 FI19613P1 FI19613P1 HELRO|EnsemblGenome=HelroG190762|UniProtKB=T1FS99 T1FS99 20211696 PTHR13800:SF12 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER-LIKE 2 calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;calcium ion transmembrane transport#GO:0070588;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;calcium ion transport#GO:0006816 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG157883|UniProtKB=T1EMH3 T1EMH3 20197773 PTHR12921:SF0 UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1 UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG83285|UniProtKB=T1G534 T1G534 20216182 PTHR45843:SF1 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG75869|UniProtKB=T1G2B8 T1G2B8 20215216 PTHR13568:SF9 FAM11A, B PROTEIN TRANSMEMBRANE PROTEIN 203 HELRO|EnsemblGenome=HelroG161348|UniProtKB=T1ERD4 T1ERD4 20199134 PTHR21096:SF0 PROTEIN FAM136A PROTEIN FAM136A cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG165178|UniProtKB=T1EWE0 T1EWE0 20200890 PTHR13526:SF8 TRANSCRIPTION FACTOR SPT20 HOMOLOG TRANSCRIPTION FACTOR SPT20 HOMOLOG molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 SAGA-type complex#GO:0070461;peptidase complex#GO:1905368;histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;chromosome#GO:0005694;SAGA complex#GO:0000124 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG185574|UniProtKB=T1FMZ7 T1FMZ7 20210196 PTHR10263:SF5 V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT V-TYPE PROTON ATPASE 16 KDA PROTEOLIPID SUBUNIT C cellular anatomical entity#GO:0110165;membrane#GO:0016020 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG69135|UniProtKB=T1FZQ1 T1FZQ1 20214299 PTHR22748:SF6 AP ENDONUCLEASE DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE hydrolase activity, acting on ester bonds#GO:0016788;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;3'-5'-DNA exonuclease activity#GO:0008296;nuclease activity#GO:0004518;DNA exonuclease activity#GO:0004529;catalytic activity#GO:0003824;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097;phosphoric diester hydrolase activity#GO:0008081;exonuclease activity#GO:0004527;3'-5' exonuclease activity#GO:0008408;phosphoric ester hydrolase activity#GO:0042578 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;base-excision repair#GO:0006284;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 HELRO|EnsemblGenome=HelroG81226|UniProtKB=T1G4B6 T1G4B6 20215914 PTHR13265:SF0 THO COMPLEX SUBUNIT 1 HPR1 mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;mRNA transport#GO:0051028;RNA localization#GO:0006403;localization#GO:0051179;organic substance transport#GO:0071702;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;THO complex#GO:0000347;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;transcription export complex#GO:0000346;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG89960|UniProtKB=T1G7J7 T1G7J7 20217044 PTHR43982:SF1 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14 cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;proteasome binding#GO:0070628;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;protein-containing complex binding#GO:0044877;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 regulation of proteolysis#GO:0030162;regulation of protein metabolic process#GO:0051246;protein modification by small protein conjugation or removal#GO:0070647;regulation of catabolic process#GO:0009894;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;regulation of nitrogen compound metabolic process#GO:0051171;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;regulation of protein catabolic process#GO:0042176;regulation of proteolysis involved in protein catabolic process#GO:1903050;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;regulation of proteasomal protein catabolic process#GO:0061136;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule metabolic process#GO:0060255;nitrogen compound metabolic process#GO:0006807;protein modification by small protein removal#GO:0070646;biological regulation#GO:0065007;protein deubiquitination#GO:0016579;protein metabolic process#GO:0019538;regulation of metabolic process#GO:0019222;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG179689|UniProtKB=T1FF13 T1FF13 20207412 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG186498|UniProtKB=T1FP01 T1FP01 20210548 PTHR12027:SF77 WNT RELATED PROTEIN WNT-5 molecular function activator activity#GO:0140677;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;protein binding#GO:0005515;cytokine activity#GO:0005125;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;neurogenesis#GO:0022008;developmental process#GO:0032502;multicellular organism development#GO:0007275;cell communication#GO:0007154;cell fate commitment#GO:0045165;cell-cell signaling by wnt#GO:0198738;nervous system development#GO:0007399;cellular process#GO:0009987;regulation of biological process#GO:0050789;system development#GO:0048731;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;cell-cell signaling#GO:0007267;signaling#GO:0023052;canonical Wnt signaling pathway#GO:0060070;Wnt signaling pathway#GO:0016055 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Angiogenesis#P00005>Wnt#P00206;Cadherin signaling pathway#P00012>Wnt#P00474 HELRO|EnsemblGenome=HelroG94807|UniProtKB=T1G931 T1G931 20217578 PTHR15852:SF54 PLASTID TRANSCRIPTIONALLY ACTIVE PROTEIN PROTEIN SSUH2 HOMOLOG HELRO|EnsemblGenome=HelroG179479|UniProtKB=T1FER9 T1FER9 20207318 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG98081|UniProtKB=T1G9K4 T1G9K4 20217750 PTHR13832:SF792 PROTEIN PHOSPHATASE 2C GM14286P macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;dephosphorylation#GO:0016311;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein phosphatase#PC00195;protein modifying enzyme#PC00260 BMP/activin signaling pathway-drosophila#P06211>PDP#P06248;SCW signaling pathway#P06216>PDP#P06324;GBB signaling pathway#P06214>PDP#P06297;DPP signaling pathway#P06213>PDP#P06280;DPP-SCW signaling pathway#P06212>PDP#P06262 HELRO|EnsemblGenome=HelroG81586|UniProtKB=T1G4G0 T1G4G0 20215958 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182425|UniProtKB=T1FI63 T1FI63 20208512 PTHR11363:SF5 60S RIBOSOMAL PROTEIN L3-RELATED LARGE RIBOSOMAL SUBUNIT PROTEIN UL3 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG64205|UniProtKB=T1FXR4 T1FXR4 20213612 PTHR19980:SF0 RNA CLEAVAGE STIMULATION FACTOR CLEAVAGE STIMULATION FACTOR SUBUNIT 3 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG84740|UniProtKB=T1G5N0 T1G5N0 20216377 PTHR42884:SF3 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED FURIN-LIKE PROTEASE 1, ISOFORMS 1_1-X_2 hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 bounding membrane of organelle#GO:0098588;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791;Golgi membrane#GO:0000139 serine protease#PC00203;protein modifying enzyme#PC00260 Activin beta signaling pathway#P06210>FUR1#P06238;Endothelin signaling pathway#P00019>furin#P00575;GBB signaling pathway#P06214>FUR1#P06298;SCW signaling pathway#P06216>FUR1#P06333;DPP-SCW signaling pathway#P06212>FUR1#P06263;DPP signaling pathway#P06213>FUR1#P06290;ALP23B signaling pathway#P06209>FUR1#P06227;Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105;BMP/activin signaling pathway-drosophila#P06211>Furin#P06244;Alzheimer disease-presenilin pathway#P00004>Furin#P00157;MYO signaling pathway#P06215>FUR1#P06318 HELRO|EnsemblGenome=HelroG75327|UniProtKB=T1G237 T1G237 20215135 PTHR23119:SF51 DISCS LARGE DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN enzyme binding#GO:0019899;protein binding#GO:0005515;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900 establishment or maintenance of cell polarity#GO:0007163;localization within membrane#GO:0051668;cellular localization#GO:0051641;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;developmental process#GO:0032502;multicellular organism development#GO:0007275;cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987;protein localization#GO:0008104;localization#GO:0051179;embryo development#GO:0009790;cellular macromolecule localization#GO:0070727;anatomical structure development#GO:0048856;establishment or maintenance of apical/basal cell polarity#GO:0035088;multicellular organismal process#GO:0032501;receptor clustering#GO:0043113;establishment or maintenance of bipolar cell polarity#GO:0061245;protein-containing complex localization#GO:0031503 basal plasma membrane#GO:0009925;basolateral plasma membrane#GO:0016323;cell junction#GO:0030054;plasma membrane region#GO:0098590;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;basal part of cell#GO:0045178;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG190341|UniProtKB=T1FRX2 T1FRX2 20211569 PTHR46218:SF4 LASP LIM AND SH3 DOMAIN PROTEIN LASP HELRO|EnsemblGenome=HelroG104520|UniProtKB=T1EDL9 T1EDL9 20194671 PTHR10334:SF498 CYSTEINE-RICH SECRETORY PROTEIN-RELATED MIP16674P defense/immunity protein#PC00090 PI3 kinase pathway#P00048>scl-1#G01545 HELRO|EnsemblGenome=HelroG193079|UniProtKB=T1FUL7 T1FUL7 20212513 PTHR15092:SF44 POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1 POLY(A)-SPECIFIC RIBONUCLEASE PARN catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;nuclease activity#GO:0004518;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;3'-5'-RNA exonuclease activity#GO:0000175;exonuclease activity#GO:0004527;3'-5' exonuclease activity#GO:0008408;RNA nuclease activity#GO:0004540 negative regulation of gene expression#GO:0010629;regulation of catabolic process#GO:0009894;heterocycle catabolic process#GO:0046700;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulatory ncRNA processing#GO:0070918;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA destabilization#GO:0050779;regulation of biological process#GO:0050789;ncRNA metabolic process#GO:0034660;mRNA metabolic process#GO:0016071;regulation of biological quality#GO:0065008;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;positive regulation of mRNA catabolic process#GO:0061014;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of catabolic process#GO:0009896;mRNA destabilization#GO:0061157;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323;positive regulation of nitrogen compound metabolic process#GO:0051173;cellular aromatic compound metabolic process#GO:0006725;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of mRNA stability#GO:0043488;regulation of mRNA catabolic process#GO:0061013;RNA metabolic process#GO:0016070;positive regulation of cellular catabolic process#GO:0031331;RNA processing#GO:0006396;biosynthetic process#GO:0009058;cellular nitrogen compound catabolic process#GO:0044270;positive regulation of metabolic process#GO:0009893;organic cyclic compound metabolic process#GO:1901360;mRNA catabolic process#GO:0006402;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;regulatory ncRNA-mediated gene silencing#GO:0031047;positive regulation of mRNA metabolic process#GO:1903313;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;negative regulation of biosynthetic process#GO:0009890;RNA 3'-end processing#GO:0031123;cellular biosynthetic process#GO:0044249;nuclear-transcribed mRNA catabolic process#GO:0000956;organic substance biosynthetic process#GO:1901576;regulation of cellular catabolic process#GO:0031329;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;positive regulation of RNA metabolic process#GO:0051254 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG176148|UniProtKB=T1FA75 T1FA75 20205724 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194878|UniProtKB=T1FWI7 T1FWI7 20213182 PTHR23275:SF100 CABRIOLET.-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185993|UniProtKB=T1FNJ1 T1FNJ1 20210388 PTHR10709:SF2 ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1 ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;Arp2/3 complex-mediated actin nucleation#GO:0034314;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;Arp2/3 protein complex#GO:0005885;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Integrin signalling pathway#P00034>Arp2/3#P00912;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Arp2/3#P00876;Cytoskeletal regulation by Rho GTPase#P00016>ARP2/3#P00511;Huntington disease#P00029>Arp2/3 complex#P00811 HELRO|EnsemblGenome=HelroG126586|UniProtKB=T1EHA5 T1EHA5 20195955 PTHR45636:SF52 PAIRED BOX PROTEIN PAX-6-RELATED-RELATED PAIRED DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG72081|UniProtKB=T1G0V2 T1G0V2 20214700 PTHR43827:SF13 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE ALDO_KETO REDUCTASE FAMILY PROTEIN oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG66825|UniProtKB=T1FYR6 T1FYR6 20213964 PTHR24235:SF29 NEUROPEPTIDE Y RECEPTOR GH23382P G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG182778|UniProtKB=T1FIQ1 T1FIQ1 20208700 PTHR12231:SF253 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG175015|UniProtKB=T1F8Q5 T1F8Q5 20205204 PTHR22848:SF0 WD40 REPEAT PROTEIN WD40 REPEAT-CONTAINING PROTEIN SMU1 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;precatalytic spliceosome#GO:0071011;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG92323|UniProtKB=T1G8E4 T1G8E4 20217341 PTHR23280:SF21 4.1 G PROTEIN PROTEIN 4.1 HOMOLOG cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG165458|UniProtKB=T1EWU1 T1EWU1 20201041 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171411|UniProtKB=T1F490 T1F490 20203639 PTHR10877:SF183 POLYCYSTIN FAMILY MEMBER AT14535P-RELATED ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG164573|UniProtKB=T1EVL2 T1EVL2 20200612 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG109340|UniProtKB=T1EES5 T1EES5 20195077 PTHR23237:SF6 NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1 H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1 snoRNA binding#GO:0030515;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA modification#GO:0009451;rRNA modification#GO:0000154;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;ribosome biogenesis#GO:0042254;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;pseudouridine synthesis#GO:0001522;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG74554|UniProtKB=T1G1S6 T1G1S6 20215024 PTHR24637:SF388 COLLAGEN NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG142152|UniProtKB=T1EJ49 T1EJ49 20196599 PTHR18945:SF865 NEUROTRANSMITTER GATED ION CHANNEL NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA7, ISOFORM E ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG99817|UniProtKB=T1G9V4 T1G9V4 20217850 PTHR43975:SF2 ZGC:101858 EG:BACR7A4.14 PROTEIN-RELATED HELRO|EnsemblGenome=HelroG189361|UniProtKB=T1FR01 T1FR01 20211248 PTHR21502:SF4 ZINC FINGER PROTEIN DZIP1 RILP-LIKE PROTEIN HOMOLOG enzyme binding#GO:0019899;protein binding#GO:0005515;small GTPase binding#GO:0031267;binding#GO:0005488 organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;cilium#GO:0005929;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG194516|UniProtKB=T1FW53 T1FW53 20213049 PTHR11905:SF159 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG186252|UniProtKB=T1FNV4 T1FNV4 20210501 PTHR11645:SF62 PYRROLINE-5-CARBOXYLATE REDUCTASE PYRROLINE-5-CARBOXYLATE REDUCTASE oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;heterocycle metabolic process#GO:0046483;proteinogenic amino acid biosynthetic process#GO:0170038;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;organic cyclic compound metabolic process#GO:1901360;alpha-amino acid biosynthetic process#GO:1901607;nitrogen compound metabolic process#GO:0006807;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;small molecule biosynthetic process#GO:0044283;L-amino acid biosynthetic process#GO:0170034;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 reductase#PC00198;oxidoreductase#PC00176 Proline biosynthesis#P02768>Pyrroline-5-carboxylate reductase#P03113 HELRO|EnsemblGenome=HelroG182763|UniProtKB=T1FIP5 T1FIP5 20208694 PTHR13817:SF73 TITIN FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN structural protein#PC00211 HELRO|EnsemblGenome=HelroG140272|UniProtKB=T1EJ03 T1EJ03 20196553 PTHR42985:SF2 SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER SODIUM-DEPENDENT MULTIVITAMIN TRANSPORTER symporter activity#GO:0015293;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;monoatomic cation transport#GO:0006812;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG94258|UniProtKB=T1G8Z7 T1G8Z7 20217544 PTHR24391:SF27 HISTONE H4 TRANSCRIPTION FACTOR-RELATED ZINC FINGER PROTEIN 1 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG182130|UniProtKB=T1FHT3 T1FHT3 20208382 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190504|UniProtKB=T1FS19 T1FS19 20211616 PTHR24412:SF480 KELCH PROTEIN KELCH-LIKE PROTEIN 8 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG63609|UniProtKB=T1FXI1 T1FXI1 20213529 PTHR45829:SF4 MITOCHONDRIAL CARRIER PROTEIN RIM2 MITOCHONDRIAL CARRIER PROTEIN RIM2 nucleobase-containing compound transmembrane transporter activity#GO:0015932;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 mitochondrial genome maintenance#GO:0000002;organophosphate ester transport#GO:0015748;transmembrane transport#GO:0055085;transport#GO:0006810;nitrogen compound transport#GO:0071705;cellular component organization#GO:0016043;cellular process#GO:0009987;mitochondrial transport#GO:0006839;localization#GO:0051179;organic substance transport#GO:0071702;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;organelle organization#GO:0006996;nucleobase-containing compound transport#GO:0015931;mitochondrion organization#GO:0007005;mitochondrial transmembrane transport#GO:1990542 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 mitochondrial carrier protein#PC00158;secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG174579|UniProtKB=T1F898 T1F898 20205047 PTHR33332:SF48 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163861|UniProtKB=T1EUJ7 T1EUJ7 20200247 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179143|UniProtKB=T1FE86 T1FE86 20207135 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED BRCT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG71078|UniProtKB=T1G0G5 T1G0G5 20214563 PTHR10969:SF33 MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED GABA(A) RECEPTOR-ASSOCIATED PROTEIN B binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389;enzyme binding#GO:0019899;protein binding#GO:0005515;lipid binding#GO:0008289;ubiquitin protein ligase binding#GO:0031625;phospholipid binding#GO:0005543;signaling receptor binding#GO:0005102;GABA receptor binding#GO:0050811 cellular component biogenesis#GO:0044085;macroautophagy#GO:0016236;autophagy of mitochondrion#GO:0000422;response to extracellular stimulus#GO:0009991;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;cellular component disassembly#GO:0022411;cellular response to starvation#GO:0009267;catabolic process#GO:0009056;mitochondrion organization#GO:0007005;autophagosome maturation#GO:0097352;cellular response to extracellular stimulus#GO:0031668;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;cellular component assembly#GO:0022607;cellular response to stimulus#GO:0051716;protein-containing complex disassembly#GO:0032984;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cell communication#GO:0007154;response to nutrient levels#GO:0031667;cellular process#GO:0009987;organelle disassembly#GO:1903008;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to stress#GO:0006950;cellular response to nutrient levels#GO:0031669;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;response to starvation#GO:0042594;cellular response to external stimulus#GO:0071496;autophagosome assembly#GO:0000045;cellular response to stress#GO:0033554;autophagy#GO:0006914 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;autophagosome membrane#GO:0000421;intracellular membrane-bounded organelle#GO:0043231;vacuolar membrane#GO:0005774;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;autophagosome#GO:0005776;intracellular anatomical structure#GO:0005622 non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG82034|UniProtKB=T1G4M2 T1G4M2 20216020 PTHR45638:SF4 CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN monoatomic cation channel activity#GO:0005261;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;ligand-gated monoatomic cation channel activity#GO:0099094;heterocyclic compound binding#GO:1901363;protein-containing complex binding#GO:0044877;anion binding#GO:0043168;ion binding#GO:0043167;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic cation transport#GO:0006812;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG181748|UniProtKB=T1FHA1 T1FHA1 20208200 PTHR12653:SF0 NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5 cellular respiration#GO:0045333;respiratory electron transport chain#GO:0022904;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;electron transport chain#GO:0022900;cellular process#GO:0009987;energy derivation by oxidation of organic compounds#GO:0015980;metabolic process#GO:0008152 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transporter complex#GO:1990351;oxidoreductase complex#GO:1990204;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;respirasome#GO:0070469;mitochondrial respiratory chain complex I#GO:0005747;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;mitochondrial respirasome#GO:0005746;transmembrane transporter complex#GO:1902495;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;respiratory chain complex I#GO:0045271;NADH dehydrogenase complex#GO:0030964;mitochondrial protein-containing complex#GO:0098798 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG184898|UniProtKB=T1FM51 T1FM51 20209900 PTHR11242:SF0 ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED TPR_REGION DOMAIN-CONTAINING PROTEIN chaperone#PC00072 HELRO|EnsemblGenome=HelroG186549|UniProtKB=T1FP09 T1FP09 20210556 PTHR11280:SF5 GLUCOSAMINE-6-PHOSPHATE ISOMERASE GLUCOSAMINE-6-PHOSPHATE ISOMERASE identical protein binding#GO:0042802;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;protein binding#GO:0005515;deaminase activity#GO:0019239;binding#GO:0005488;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;carbohydrate derivative metabolic process#GO:1901135;carbohydrate derivative catabolic process#GO:1901136;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;nitrogen compound metabolic process#GO:0006807;amino sugar catabolic process#GO:0046348;catabolic process#GO:0009056;amino sugar metabolic process#GO:0006040;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;amide metabolic process#GO:0043603;carboxylic acid metabolic process#GO:0019752;small molecule metabolic process#GO:0044281;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 isomerase#PC00135;metabolite interconversion enzyme#PC00262 N-acetylglucosamine metabolism#P02756>Glucosamine-6-phosphate deaminase#P03041 HELRO|EnsemblGenome=HelroG71793|UniProtKB=T1G0R8 T1G0R8 20214666 PTHR12563:SF17 GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE DIHYDROXYACETONE PHOSPHATE ACYLTRANSFERASE transferase#PC00220;acyltransferase#PC00042;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG192359|UniProtKB=T1FTV0 T1FTV0 20212247 PTHR24343:SF304 SERINE/THREONINE KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG133157|UniProtKB=T1EI03 T1EI03 20196203 PTHR45695:SF26 LEUCOKININ RECEPTOR-RELATED NEUROPEPTIDE CCHAMIDE-1 RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG159340|UniProtKB=T1ENX0 T1ENX0 20198270 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG189990|UniProtKB=T1FRK4 T1FRK4 20211451 PTHR23138:SF142 RAN BINDING PROTEIN RAN-BINDING PROTEIN 3B-RELATED scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG164225|UniProtKB=T1EV45 T1EV45 20200445 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168361|UniProtKB=T1F0H0 T1F0H0 20202320 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG185250|UniProtKB=T1FMK1 T1FMK1 20210050 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG189017|UniProtKB=T1FQK5 T1FQK5 20211102 PTHR23231:SF17 GERM CELL-LESS PROTEIN BTB DOMAIN-CONTAINING PROTEIN ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG94416|UniProtKB=T1G910 T1G910 20217557 PTHR13864:SF10 T-CELL ACUTE LYMPHOCYTIC LEUKEMIA/STEM CELL LEUKEMIA-RELATED HELIX-LOOP-HELIX PROTEIN 2 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG174018|UniProtKB=T1F7H5 T1F7H5 20204774 PTHR46954:SF1 C2H2-TYPE DOMAIN-CONTAINING PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179299|UniProtKB=T1FEI2 T1FEI2 20207231 PTHR24026:SF118 FAT ATYPICAL CADHERIN-RELATED DE-CADHERIN cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440;Alzheimer disease-presenilin pathway#P00004>E-cadherin#P00118 HELRO|EnsemblGenome=HelroG70474|UniProtKB=T1G069 T1G069 20214467 PTHR24416:SF550 TYROSINE-PROTEIN KINASE RECEPTOR FIBROBLAST GROWTH FACTOR RECEPTOR HOMOLOG 1-RELATED signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG149692|UniProtKB=T1EKD3 T1EKD3 20197033 PTHR10027:SF33 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic ion-gated channel activity#GO:0022839;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium-activated cation channel activity#GO:0005227;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG181010|UniProtKB=T1FGI7 T1FGI7 20207936 PTHR13041:SF3 JTB PROTEIN-RELATED PROTEIN JTB mitotic cytokinesis#GO:0000281;cell division#GO:0051301;mitotic cell cycle#GO:0000278;cytoskeleton-dependent cytokinesis#GO:0061640;cell cycle process#GO:0022402;cell cycle#GO:0007049;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047;cytokinesis#GO:0000910 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;midbody#GO:0030496;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;spindle#GO:0005819;centrosome#GO:0005813;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG169145|UniProtKB=T1F1G8 T1F1G8 20202668 PTHR47027:SF20 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN HELRO|EnsemblGenome=HelroG165283|UniProtKB=T1EWJ2 T1EWJ2 20200942 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188365|UniProtKB=T1FPX4 T1FPX4 20210871 PTHR10316:SF40 MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED LD27118P regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG159436|UniProtKB=T1EP12 T1EP12 20198312 PTHR15907:SF161 DUF614 FAMILY PROTEIN-RELATED PLAC8 FAMILY PROTEIN HELRO|EnsemblGenome=HelroG76784|UniProtKB=T1G2P5 T1G2P5 20215343 PTHR11849:SF302 ETS ETS DOMAIN-CONTAINING PROTEIN-RELATED transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG167941|UniProtKB=T1EZZ7 T1EZZ7 20202147 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG155122|UniProtKB=T1ELH0 T1ELH0 20197420 PTHR23349:SF50 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST PROTEIN TWIST sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG97247|UniProtKB=T1G9G2 T1G9G2 20217709 PTHR48041:SF116 ABC TRANSPORTER G FAMILY MEMBER 28 PROTEIN BROWN transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG72038|UniProtKB=T1G0U4 T1G0U4 20214692 PTHR18966:SF422 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED signaling receptor activity#GO:0038023;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;ligand-gated channel activity#GO:0022834 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019 HELRO|EnsemblGenome=HelroG168432|UniProtKB=T1F0L2 T1F0L2 20202362 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG111136|UniProtKB=T1EF86 T1EF86 20195238 PTHR12603:SF0 CCR4-NOT TRANSCRIPTION COMPLEX RELATED CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 CCR4-NOT complex#GO:0030014;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG98540|UniProtKB=T1G9N5 T1G9N5 20217781 PTHR10751:SF29 GUANYLATE BINDING PROTEIN ATLASTIN GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 heterotrimeric G-protein#PC00117;G-protein#PC00020 HELRO|EnsemblGenome=HelroG183162|UniProtKB=T1FJ86 T1FJ86 20208885 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG83504|UniProtKB=T1G564 T1G564 20216212 PTHR12086:SF11 EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN EF-HAND DOMAIN-CONTAINING FAMILY MEMBER C2 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG185794|UniProtKB=T1FNA7 T1FNA7 20210304 PTHR11735:SF14 TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG71994|UniProtKB=T1G0T9 T1G0T9 20214687 PTHR19300:SF57 BETA-1,4-GALACTOSYLTRANSFERASE BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE galactosyltransferase activity#GO:0008378;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycosylation#GO:0070085;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG193750|UniProtKB=T1FVB4 T1FVB4 20212760 PTHR28625:SF1 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 35 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 35 regulation of microtubule-based process#GO:0032886;positive regulation of organelle organization#GO:0010638;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;regulation of plasma membrane bounded cell projection organization#GO:0120035;positive regulation of cell cycle#GO:0045787;regulation of cilium assembly#GO:1902017;positive regulation of cellular process#GO:0048522;regulation of cell cycle process#GO:0010564;regulation of biological process#GO:0050789;regulation of centrosome cycle#GO:0046605;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;positive regulation of cell cycle process#GO:0090068;regulation of cell projection assembly#GO:0060491;regulation of organelle assembly#GO:1902115;regulation of cell projection organization#GO:0031344;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;regulation of centriole replication#GO:0046599;regulation of cell cycle#GO:0051726;positive regulation of cellular component biogenesis#GO:0044089;positive regulation of biological process#GO:0048518;regulation of centrosome duplication#GO:0010824 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;centriole#GO:0005814;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG159935|UniProtKB=T1EPK8 T1EPK8 20198508 PTHR16484:SF17 PARTITIONING DEFECTIVE 3 RELATED BAZOOKA, ISOFORM B lipid binding#GO:0008289;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;binding#GO:0005488 establishment or maintenance of cell polarity#GO:0007163;cellular localization#GO:0051641;organelle localization#GO:0051640;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;macromolecule localization#GO:0033036;microtubule cytoskeleton organization#GO:0000226;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cellular process#GO:0009987;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of cell polarity#GO:0030010;cellular macromolecule localization#GO:0070727;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;organelle organization#GO:0006996;centrosome localization#GO:0051642;establishment of localization in cell#GO:0051649;establishment or maintenance of apical/basal cell polarity#GO:0035088;cytoskeleton organization#GO:0007010;establishment or maintenance of bipolar cell polarity#GO:0061245;establishment of organelle localization#GO:0051656 cytoplasm#GO:0005737;anchoring junction#GO:0070161;cell-cell junction#GO:0005911;cell junction#GO:0030054;plasma membrane region#GO:0098590;adherens junction#GO:0005912;cell cortex#GO:0005938;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886;apical junction complex#GO:0043296;apical part of cell#GO:0045177;intracellular anatomical structure#GO:0005622;apical plasma membrane#GO:0016324 HELRO|EnsemblGenome=HelroG192818|UniProtKB=T1FUB9 T1FUB9 20212415 PTHR10921:SF1 NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1 NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 vesicle transport along microtubule#GO:0047496;establishment or maintenance of cell polarity#GO:0007163;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;organelle localization#GO:0051640;nuclear division#GO:0000280;transport#GO:0006810;establishment of spindle orientation#GO:0051294;cell cycle process#GO:0022402;microtubule-based movement#GO:0007018;microtubule cytoskeleton organization#GO:0000226;protein-containing complex assembly#GO:0065003;centrosome cycle#GO:0007098;microtubule cytoskeleton organization involved in mitosis#GO:1902850;microtubule polymerization or depolymerization#GO:0031109;mitotic cell cycle process#GO:1903047;chromosome segregation#GO:0007059;establishment of cell polarity#GO:0030010;mitotic cell cycle#GO:0000278;microtubule polymerization#GO:0046785;establishment of localization#GO:0051234;establishment of vesicle localization#GO:0051650;supramolecular fiber organization#GO:0097435;cytoskeleton-dependent intracellular transport#GO:0030705;cytoskeleton organization#GO:0007010;mitotic nuclear division#GO:0140014;establishment of organelle localization#GO:0051656;spindle localization#GO:0051653;cellular component assembly#GO:0022607;establishment of chromosome localization#GO:0051303;vesicle localization#GO:0051648;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule organizing center organization#GO:0031023;establishment of spindle localization#GO:0051293;transport along microtubule#GO:0010970;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of mitotic spindle localization#GO:0040001;establishment of mitotic spindle orientation#GO:0000132;microtubule-based transport#GO:0099111;microtubule-based process#GO:0007017;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;centrosome localization#GO:0051642;protein polymerization#GO:0051258;cell cycle#GO:0007049;establishment of localization in cell#GO:0051649;organelle fission#GO:0048285;intracellular transport#GO:0046907;chromosome localization#GO:0050000;microtubule nucleation#GO:0007020;organelle transport along microtubule#GO:0072384;vesicle cytoskeletal trafficking#GO:0099518 supramolecular complex#GO:0099080;microtubule organizing center#GO:0005815;kinetochore#GO:0000776;condensed chromosome, centromeric region#GO:0000779;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;centrosome#GO:0005813;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;chromosome#GO:0005694;microtubule cytoskeleton#GO:0015630;chromosomal region#GO:0098687;cytoskeleton#GO:0005856 HELRO|EnsemblGenome=HelroG166348|UniProtKB=T1EY16 T1EY16 20201466 PTHR48112:SF22 HIGH MOBILITY GROUP PROTEIN DSP1 MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG111636|UniProtKB=T1EFD0 T1EFD0 20195282 PTHR13793:SF160 PHD FINGER PROTEINS PHD FINGER PROTEIN RHINOCEROS regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG177916|UniProtKB=T1FCG7 T1FCG7 20206516 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG160540|UniProtKB=T1EQE1 T1EQE1 20198791 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194755|UniProtKB=T1FWD4 T1FWD4 20213129 PTHR11827:SF73 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS KAZACHOC, ISOFORM G inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium ion transmembrane transporter activity#GO:0015079;symporter activity#GO:0015293;chloride transmembrane transporter activity#GO:0015108;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 inorganic ion homeostasis#GO:0098771;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;inorganic anion transmembrane transport#GO:0098661;import across plasma membrane#GO:0098739;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;inorganic anion transport#GO:0015698;potassium ion transport#GO:0006813;regulation of anatomical structure size#GO:0090066;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;monoatomic anion transmembrane transport#GO:0098656;chloride transport#GO:0006821;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;cellular component organization#GO:0016043;cellular process#GO:0009987;chemical homeostasis#GO:0048878;regulation of cellular component size#GO:0032535;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;regulation of cell size#GO:0008361;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;potassium ion import across plasma membrane#GO:1990573 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG81905|UniProtKB=T1G4K6 T1G4K6 20216004 PTHR46002:SF5 EG:114D9.1 PROTEIN-RELATED EF-HAND DOMAIN-CONTAINING PROTEIN-RELATED regulation of sodium ion transmembrane transporter activity#GO:2000649;regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;regulation of sodium ion transport#GO:0002028;regulation of metal ion transport#GO:0010959;positive regulation of molecular function#GO:0044093;regulation of localization#GO:0032879;positive regulation of transport#GO:0051050;regulation of monoatomic cation transmembrane transport#GO:1904062;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of transporter activity#GO:0032411;regulation of transport#GO:0051049;regulation of cellular process#GO:0050794;regulation of molecular function#GO:0065009;biological regulation#GO:0065007;regulation of monoatomic ion transmembrane transporter activity#GO:0032412;regulation of transmembrane transporter activity#GO:0022898;regulation of monoatomic ion transport#GO:0043269;regulation of transporter activity#GO:0032409;positive regulation of biological process#GO:0048518 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG92436|UniProtKB=T1G8G3 T1G8G3 20217360 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG84500|UniProtKB=T1G5J2 T1G5J2 20216339 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-LIKE 1 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;localization#GO:0051179;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 membrane protein complex#GO:0098796;synapse#GO:0045202;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron projection#GO:0043005;transmembrane transporter complex#GO:1902495;cell projection#GO:0042995;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HELRO|EnsemblGenome=HelroG170531|UniProtKB=T1F360 T1F360 20203259 PTHR10476:SF1 CHARGED MULTIVESICULAR BODY PROTEIN CHARGED MULTIVESICULAR BODY PROTEIN 3 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG97056|UniProtKB=T1G9F2 T1G9F2 20217699 PTHR11699:SF211 ALDEHYDE DEHYDROGENASE-RELATED ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1 dehydrogenase#PC00092;oxidoreductase#PC00176 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402;Ornithine degradation#P02758>Aminobutyraldehyde dehydrogenase#P03055;Phenylethylamine degradation#P02766>Phenylacetaldehyde dehydrogenase#P03102 HELRO|EnsemblGenome=HelroG75379|UniProtKB=T1G243 T1G243 20215141 PTHR23113:SF99 GUANINE NUCLEOTIDE EXCHANGE FACTOR RASGEF DOMAIN-CONTAINING PROTEIN guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG171023|UniProtKB=T1F3Q2 T1F3Q2 20203451 PTHR24026:SF133 FAT ATYPICAL CADHERIN-RELATED CADHERIN-RELATED FAMILY MEMBER 2 cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HELRO|EnsemblGenome=HelroG157395|UniProtKB=T1EMA8 T1EMA8 20197708 PTHR23137:SF6 VESICLE TRANSPORT PROTEIN-RELATED VESICLE TRANSPORT PROTEIN HELRO|EnsemblGenome=HelroG185258|UniProtKB=T1FMK4 T1FMK4 20210053 PTHR10965:SF0 60S RIBOSOMAL PROTEIN L38 LARGE RIBOSOMAL SUBUNIT PROTEIN EL38 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG192303|UniProtKB=T1FTT2 T1FTT2 20212229 PTHR14186:SF20 INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED CYSTEINE-RICH MOTOR NEURON 1 PROTEIN-LIKE regulation of response to stimulus#GO:0048583;biological regulation#GO:0065007;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;regulation of signaling#GO:0023051 HELRO|EnsemblGenome=HelroG193552|UniProtKB=T1FV44 T1FV44 20212690 PTHR21477:SF13 ZGC:172139 KIAA0930 HELRO|EnsemblGenome=HelroG176111|UniProtKB=T1FA53 T1FA53 20205702 PTHR23320:SF165 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MARVEL DOMAIN-CONTAINING PROTEIN transporter#PC00227 HELRO|EnsemblGenome=HelroG177742|UniProtKB=T1FC62 T1FC62 20206411 PTHR46186:SF2 CYSTATIN CYSTATIN peptidase inhibitor activity#GO:0030414;molecular function regulator activity#GO:0098772;cysteine-type endopeptidase inhibitor activity#GO:0004869;peptidase regulator activity#GO:0061134;enzyme inhibitor activity#GO:0004857;endopeptidase regulator activity#GO:0061135;endopeptidase inhibitor activity#GO:0004866;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 regulation of proteolysis#GO:0030162;negative regulation of hydrolase activity#GO:0051346;negative regulation of biological process#GO:0048519;regulation of protein metabolic process#GO:0051246;regulation of cysteine-type endopeptidase activity#GO:2000116;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of cysteine-type endopeptidase activity#GO:2000117;negative regulation of peptidase activity#GO:0010466;negative regulation of endopeptidase activity#GO:0010951;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of proteolysis#GO:0045861;regulation of catalytic activity#GO:0050790;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of molecular function#GO:0065009;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336;regulation of endopeptidase activity#GO:0052548;regulation of peptidase activity#GO:0052547;negative regulation of catalytic activity#GO:0043086;regulation of metabolic process#GO:0019222;negative regulation of molecular function#GO:0044092 cytoplasm#GO:0005737;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG78187|UniProtKB=T1G391 T1G391 20215539 PTHR11920:SF502 GUANYLYL CYCLASE GUANYLATE CYCLASE adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG68450|UniProtKB=T1FZF0 T1FZF0 20214198 PTHR24119:SF0 ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6 ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6 nucleotide binding#GO:0000166;carbohydrate derivative binding#GO:0097367;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;amide binding#GO:0033218;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;lipid binding#GO:0008289;ion binding#GO:0043167;anion binding#GO:0043168 HELRO|EnsemblGenome=HelroG182310|UniProtKB=T1FI14 T1FI14 20208463 PTHR12048:SF0 CCAAT-BINDING FACTOR-RELATED CCAAT_ENHANCER-BINDING PROTEIN ZETA membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG190219|UniProtKB=T1FRS3 T1FRS3 20211520 PTHR23103:SF15 ALZHEIMER'S DISEASE BETA-AMYLOID RELATED AMYLOID-BETA-LIKE PROTEIN protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG162477|UniProtKB=T1ESQ2 T1ESQ2 20199602 PTHR32001:SF1 KERATINOCYTE-ASSOCIATED PROTEIN 2 KERATINOCYTE-ASSOCIATED PROTEIN 2 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein glycosylation#GO:0006486;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;protein metabolic process#GO:0019538;glycosylation#GO:0070085;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG190469|UniProtKB=T1FS04 T1FS04 20211601 PTHR11731:SF202 PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED DIPEPTIDYL PEPTIDASE FAMILY MEMBER 2 hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG193312|UniProtKB=T1FUV3 T1FUV3 20212599 PTHR13314:SF2 CALCIUM CHANNEL FLOWER HOMOLOG CALCIUM CHANNEL FLOWER HOMOLOG localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;cellular process#GO:0009987;transport#GO:0006810 HELRO|EnsemblGenome=HelroG191622|UniProtKB=T1FT50 T1FT50 20211997 PTHR31281:SF3 PROTEIN FAM219A PROTEIN FAM219A HELRO|EnsemblGenome=HelroG82669|UniProtKB=T1G4V0 T1G4V0 20216098 PTHR24343:SF466 SERINE/THREONINE KINASE AMP-ACTIVATED PROTEIN KINASE ALPHA SUBUNIT, ISOFORM A transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG95876|UniProtKB=T1G985 T1G985 20217632 PTHR13808:SF1 CBP/P300-RELATED HISTONE ACETYLTRANSFERASE histone modifying activity#GO:0140993;nucleic acid binding#GO:0003676;acyltransferase activity#GO:0016746;peptide N-acetyltransferase activity#GO:0034212;binding#GO:0005488;catalytic activity#GO:0003824;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;N-acyltransferase activity#GO:0016410;histone acetyltransferase activity#GO:0004402;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;molecular adaptor activity#GO:0060090;N-acetyltransferase activity#GO:0008080;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;chromatin DNA binding#GO:0031490;transferase activity#GO:0016740;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;protein-containing complex binding#GO:0044877;catalytic activity, acting on a protein#GO:0140096 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of RNA metabolic process#GO:0051254;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;chromatin#GO:0000785;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;chromosome#GO:0005694 histone modifying enzyme#PC00261 DPP signaling pathway#P06213>NEJ#P06284;TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282;SCW signaling pathway#P06216>NEJ#P06328;GBB signaling pathway#P06214>NEJ#P06295;BMP/activin signaling pathway-drosophila#P06211>NEJ#P06246;p53 pathway#P00059>CBP#P04623;Wnt signaling pathway#P00057>CBP#P01448;Transcription regulation by bZIP transcription factor#P00055>CBP/P300#P01387;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CREB#P00713;DPP-SCW signaling pathway#P06212>NEJ#P06260;Huntington disease#P00029>CBP#P00777 HELRO|EnsemblGenome=HelroG185237|UniProtKB=T1FMJ6 T1FMJ6 20210045 PTHR47980:SF19 LD44762P RAS-RELATED PROTEIN RAB-3 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;cytoskeletal protein binding#GO:0008092;myosin binding#GO:0017022;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;ribonucleoside triphosphate phosphatase activity#GO:0017111 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;protein secretion#GO:0009306;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;establishment of protein localization to extracellular region#GO:0035592;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;protein transport#GO:0015031;protein localization to extracellular region#GO:0071692;export from cell#GO:0140352;secretion by cell#GO:0032940 presynapse#GO:0098793;synapse#GO:0045202;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;secretory vesicle#GO:0099503;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG184869|UniProtKB=T1FM37 T1FM37 20209886 PTHR11239:SF12 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10 catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;RNA polymerase activity#GO:0097747;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG184476|UniProtKB=T1FLA2 T1FLA2 20209601 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169345|UniProtKB=T1F1T2 T1F1T2 20202782 PTHR14312:SF6 CREB/ATF BZIP TRANSCRIPTION FACTOR SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG193467|UniProtKB=T1FV10 T1FV10 20212656 PTHR11618:SF4 TRANSCRIPTION INITIATION FACTOR IIB-RELATED TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;transcription by RNA polymerase III#GO:0006383;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;aromatic compound biosynthetic process#GO:0019438;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 general transcription factor#PC00259 Transcription regulation by bZIP transcription factor#P00055>TFIIB#P01397;General transcription regulation#P00023>TFIIB#P00668 HELRO|EnsemblGenome=HelroG157785|UniProtKB=T1EMF6 T1EMF6 20197756 PTHR24072:SF0 RHO FAMILY GTPASE RHO-RELATED GTP-BINDING PROTEIN RHOB GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 small GTPase#PC00208 Ras Pathway#P04393>Rho#P04578;Integrin signalling pathway#P00034>Rho#P00948;Angiogenesis#P00005>GTPase#P00254;Axon guidance mediated by Slit/Robo#P00008>Rho#P00355;Cytoskeletal regulation by Rho GTPase#P00016>Rho#P00507;PDGF signaling pathway#P00047>Ras#P01154;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RhoA#P00740 HELRO|EnsemblGenome=HelroG188228|UniProtKB=T1FPS6 T1FPS6 20210823 PTHR47658:SF1 HIGH MOBILITY GROUP B PROTEIN 12-RELATED MEIOSIS INITIATOR PROTEIN HELRO|EnsemblGenome=HelroG166150|UniProtKB=T1EXU4 T1EXU4 20201394 PTHR10663:SF342 GUANYL-NUCLEOTIDE EXCHANGE FACTOR FI21420P1 cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;organelle organization#GO:0006996 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG68444|UniProtKB=T1FZE9 T1FZE9 20214197 PTHR10169:SF38 DNA TOPOISOMERASE/GYRASE DNA TOPOISOMERASE 2 cellular aromatic compound metabolic process#GO:0006725;nuclear division#GO:0000280;cell cycle process#GO:0022402;nucleobase-containing compound metabolic process#GO:0006139;chromosome segregation#GO:0007059;reciprocal homologous recombination#GO:0140527;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;meiotic cell cycle process#GO:1903046;meiosis I cell cycle process#GO:0061982;reciprocal meiotic recombination#GO:0007131;reproductive process#GO:0022414;meiosis I#GO:0007127;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;macromolecule metabolic process#GO:0043170;meiotic cell cycle#GO:0051321;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;DNA recombination#GO:0006310;resolution of meiotic recombination intermediates#GO:0000712;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;reproduction#GO:0000003;meiotic nuclear division#GO:0140013;organelle organization#GO:0006996;chromosome organization#GO:0051276;sexual reproduction#GO:0019953;cell cycle#GO:0007049;organelle fission#GO:0048285;homologous recombination#GO:0035825;DNA metabolic process#GO:0006259 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 DNA replication#P00017>Top#P00530;DNA replication#P00017>DNA Topisomerase#P00536 HELRO|EnsemblGenome=HelroG167974|UniProtKB=T1F009 T1F009 20202159 PTHR46908:SF8 CUBILIN-LIKE PROTEIN C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193054|UniProtKB=T1FUK7 T1FUK7 20212503 PTHR10671:SF108 EPITHELIAL MEMBRANE PROTEIN-RELATED CLAUDIN FAMILY PROTEIN-RELATED cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG189175|UniProtKB=T1FQR2 T1FQR2 20211159 PTHR24020:SF84 COLLAGEN ALPHA VWFA DOMAIN-CONTAINING PROTEIN extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG106742|UniProtKB=T1EE45 T1EE45 20194847 PTHR10075:SF100 BASIGIN RELATED FASCICLIN-2 cell adhesion molecule binding#GO:0050839;cell-cell adhesion mediator activity#GO:0098632;protein binding#GO:0005515;binding#GO:0005488 neuron projection guidance#GO:0097485;cell recognition#GO:0008037;neurogenesis#GO:0022008;cell projection organization#GO:0030030;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;axonogenesis#GO:0007409;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156;cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cell morphogenesis#GO:0000902;cellular process#GO:0009987;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure development#GO:0048856;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;axon#GO:0030424 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG173254|UniProtKB=T1F6L6 T1F6L6 20204465 PTHR13082:SF0 SAP18 HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18 molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;protein binding#GO:0005515;transcription factor binding#GO:0008134 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 Hedgehog signaling pathway#P00025>Sap18#P00697 HELRO|EnsemblGenome=HelroG101372|UniProtKB=T1ED42 T1ED42 20213287 PTHR23122:SF72 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK GUANYLATE KINASE-LIKE DOMAIN-CONTAINING PROTEIN cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;cell-cell junction#GO:0005911;anchoring junction#GO:0070161;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG76239|UniProtKB=T1G2H2 T1G2H2 20215270 PTHR11157:SF69 FATTY ACID ACYL TRANSFERASE-RELATED ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 7 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;monocarboxylic acid biosynthetic process#GO:0072330;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;organic acid metabolic process#GO:0006082;membrane lipid biosynthetic process#GO:0046467;sphingolipid metabolic process#GO:0006665;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;fatty acid metabolic process#GO:0006631;membrane lipid metabolic process#GO:0006643;nitrogen compound metabolic process#GO:0006807;small molecule biosynthetic process#GO:0044283;cellular lipid metabolic process#GO:0044255;carboxylic acid metabolic process#GO:0019752;sphingolipid biosynthetic process#GO:0030148;fatty acid biosynthetic process#GO:0006633;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG67527|UniProtKB=T1FZ22 T1FZ22 20214070 PTHR10658:SF81 PHOSPHATIDYLINOSITOL TRANSFER PROTEIN PROTEIN RETINAL DEGENERATION B cation binding#GO:0043169;phosphatidylcholine binding#GO:0031210;lipid transfer activity#GO:0120013;small molecule binding#GO:0036094;binding#GO:0005488;phosphatidylcholine transporter activity#GO:0008525;phospholipid transporter activity#GO:0005548;lipid binding#GO:0008289;ion binding#GO:0043167;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;transporter activity#GO:0005215;lipid transporter activity#GO:0005319 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG68803|UniProtKB=T1FZJ6 T1FZJ6 20214244 PTHR24416:SF631 TYROSINE-PROTEIN KINASE RECEPTOR SERINE_THREONINE_TYROSINE KINASE 1 signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG82938|UniProtKB=T1G4Y2 T1G4Y2 20216130 PTHR15377:SF3 TRANSCRIPTION ELONGATION REGULATOR 1 WW DOMAIN-CONTAINING PROTEIN molecular adaptor activity#GO:0060090;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;RNA polymerase binding#GO:0070063;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;protein binding#GO:0005515;enzyme binding#GO:0019899 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG69374|UniProtKB=T1FZU2 T1FZU2 20214340 PTHR10605:SF65 HEPARAN SULFATE SULFOTRANSFERASE GH20068P sulfotransferase activity#GO:0008146;transferase activity#GO:0016740;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity#GO:0003824 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG185836|UniProtKB=T1FNC7 T1FNC7 20210324 PTHR10003:SF71 SUPEROXIDE DISMUTASE CU-ZN -RELATED SUPEROXIDE DISMUTASE [CU-ZN] cation binding#GO:0043169;antioxidant activity#GO:0016209;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;copper ion binding#GO:0005507;metal ion binding#GO:0046872;ion binding#GO:0043167;oxidoreductase activity#GO:0016491 cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;cellular metabolic process#GO:0044237;response to oxidative stress#GO:0006979;cellular process#GO:0009987;response to stimulus#GO:0050896;cellular response to oxygen-containing compound#GO:1901701;detoxification#GO:0098754;response to stress#GO:0006950;response to chemical#GO:0042221;cellular response to oxidative stress#GO:0034599;response to toxic substance#GO:0009636;response to reactive oxygen species#GO:0000302;cellular response to stress#GO:0033554;metabolic process#GO:0008152 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG67618|UniProtKB=T1FZ30 T1FZ30 20214078 PTHR24223:SF461 ATP-BINDING CASSETTE SUB-FAMILY C ATP-BINDING CASSETTE SUB-FAMILY C MEMBER SUR transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG164412|UniProtKB=T1EVE2 T1EVE2 20200542 PTHR11850:SF295 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS ACHINTYA, ISOFORM C-RELATED DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG88370|UniProtKB=T1G717 T1G717 20216864 PTHR24393:SF136 ZINC FINGER PROTEIN LD28458P-RELATED DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG165164|UniProtKB=T1EWD0 T1EWD0 20200880 PTHR24042:SF5 NEL HOMOLOG EGF-LIKE CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG62703|UniProtKB=T1FX39 T1FX39 20213387 PTHR19855:SF28 WD40 REPEAT PROTEIN 12, 37 CCR4-ASSOCIATED FACTOR 4 HELRO|EnsemblGenome=HelroG191111|UniProtKB=T1FSL7 T1FSL7 20211814 PTHR14948:SF25 NG5 DUF4190 DOMAIN-CONTAINING PROTEIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG163167|UniProtKB=T1ETR1 T1ETR1 20199961 PTHR12357:SF3 YTH YT521-B HOMOLOGY DOMAIN-CONTAINING YTH DOMAIN-CONTAINING PROTEIN 1 RNA binding#GO:0003723;molecular adaptor activity#GO:0060090;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159;protein-macromolecule adaptor activity#GO:0030674 cellular aromatic compound metabolic process#GO:0006725;regulation of nitrogen compound metabolic process#GO:0051171;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;regulation of mRNA processing#GO:0050684;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;nucleic acid metabolic process#GO:0090304;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;biological regulation#GO:0065007;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of metabolic process#GO:0019222;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG112487|UniProtKB=T1EFK4 T1EFK4 20195356 PTHR10183:SF379 CALPAIN CALPAIN-5 cysteine protease#PC00081;protease#PC00190 Huntington disease#P00029>Calpain#P00788 HELRO|EnsemblGenome=HelroG109117|UniProtKB=T1EEQ5 T1EEQ5 20195057 PTHR45679:SF2 ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2 ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 3 hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 carbohydrate derivative metabolic process#GO:1901135;macromolecule modification#GO:0043412;protein catabolic process#GO:0030163;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;macromolecule catabolic process#GO:0009057;response to endoplasmic reticulum stress#GO:0034976;response to oxygen-containing compound#GO:1901700;macromolecule metabolic process#GO:0043170;carbohydrate derivative catabolic process#GO:1901136;organonitrogen compound metabolic process#GO:1901564;ERAD pathway#GO:0036503;response to organonitrogen compound#GO:0010243;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;cellular response to stress#GO:0033554 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG172632|UniProtKB=T1F5P1 T1F5P1 20204140 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG66584|UniProtKB=T1FYM9 T1FYM9 20213927 PTHR12111:SF1 SPLICING FACTOR YJU2 SPLICING FACTOR YJU2 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;U2-type spliceosomal complex#GO:0005684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG115778|UniProtKB=T1EGA4 T1EGA4 20195606 PTHR22836:SF0 WD40 REPEAT PROTEIN PRE-MRNA 3' END PROCESSING PROTEIN WDR33 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;mRNA polyadenylation#GO:0006378;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;mRNA 3'-end processing#GO:0031124;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mRNA processing#GO:0006397;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;mRNA cleavage factor complex#GO:0005849;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG171602|UniProtKB=T1F4G0 T1F4G0 20203709 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182753|UniProtKB=T1FIP2 T1FIP2 20208691 PTHR17490:SF10 SUA5 THREONYLCARBAMOYL-AMP SYNTHASE tRNA binding#GO:0000049;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;transferase activity#GO:0016740;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772 biological regulation#GO:0065007;regulation of biological quality#GO:0065008 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG158962|UniProtKB=T1ENF8 T1ENF8 20198108 PTHR23220:SF122 INTEGRIN ALPHA INTEGRIN ALPHA-PS1 cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;integrin binding#GO:0005178;binding#GO:0005488;signaling receptor binding#GO:0005102 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;cell adhesion mediated by integrin#GO:0033627;cell-cell adhesion#GO:0098609;cell communication#GO:0007154;cell adhesion#GO:0007155;cell-substrate adhesion#GO:0031589;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cell-matrix adhesion#GO:0007160;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;integrin-mediated signaling pathway#GO:0007229;biological regulation#GO:0065007;signaling#GO:0023052 receptor complex#GO:0043235;membrane protein complex#GO:0098796;external side of plasma membrane#GO:0009897;cell surface#GO:0009986;protein-containing complex#GO:0032991;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;side of membrane#GO:0098552;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;integrin#PC00126 Integrin signalling pathway#P00034>Integrin alpha#P00941 HELRO|EnsemblGenome=HelroG164284|UniProtKB=T1EV74 T1EV74 20200474 PTHR24410:SF23 HL07962P-RELATED BTB DOMAIN-CONTAINING PROTEIN-RELATED defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG188097|UniProtKB=T1FPM6 T1FPM6 20210773 PTHR13723:SF281 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE PAPILIN metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG83167|UniProtKB=T1G514 T1G514 20216162 PTHR45849:SF1 FACT COMPLEX SUBUNIT SSRP1 FACT COMPLEX SUBUNIT SSRP1 nucleosome binding#GO:0031491;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;chromatin binding#GO:0003682;histone binding#GO:0042393 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;chromatin#GO:0000785;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;transcription elongation factor complex#GO:0008023;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG187042|UniProtKB=T1FP60 T1FP60 20210607 PTHR11629:SF63 VACUOLAR PROTON ATPASES V-TYPE PROTON ATPASE SUBUNIT A enzyme binding#GO:0019899;protein binding#GO:0005515;binding#GO:0005488 regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;regulation of biological quality#GO:0065008;intracellular monoatomic cation homeostasis#GO:0030003;biological regulation#GO:0065007;intracellular pH reduction#GO:0051452;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic ion homeostasis#GO:0006873;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;vacuolar acidification#GO:0007035;regulation of cellular pH#GO:0030641;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;vacuolar membrane#GO:0005774;ATPase complex#GO:1904949;vacuole#GO:0005773;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;proton-transporting two-sector ATPase complex#GO:0016469;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG164196|UniProtKB=T1EV30 T1EV30 20200430 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188648|UniProtKB=T1FQ79 T1FQ79 20210976 PTHR23240:SF26 DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED 5' EXONUCLEASE APOLLO hydrolase activity, acting on ester bonds#GO:0016788;nucleic acid binding#GO:0003676;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;nuclease activity#GO:0004518;DNA exonuclease activity#GO:0004529;5'-3' exonuclease activity#GO:0008409;binding#GO:0005488;catalytic activity#GO:0003824;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;damaged DNA binding#GO:0003684;catalytic activity, acting on a nucleic acid#GO:0140640;exonuclease activity#GO:0004527;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;hydrolase activity#GO:0016787;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;double-strand break repair#GO:0006302;telomere organization#GO:0032200;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;telomere maintenance#GO:0000723;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;double-strand break repair via nonhomologous end joining#GO:0006303;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;response to stress#GO:0006950;interstrand cross-link repair#GO:0036297;organelle organization#GO:0006996;chromosome organization#GO:0051276;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;metabolic process#GO:0008152 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG100087|UniProtKB=T1ECY5 T1ECY5 20194437 PTHR24007:SF7 BRCA1-ASSOCIATED PROTEIN BRCA1-ASSOCIATED PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;small GTPase-mediated signal transduction#GO:0007264;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;Ras protein signal transduction#GO:0007265;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cell communication#GO:0007154;cellular process#GO:0009987;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG173516|UniProtKB=T1F6X2 T1F6X2 20204571 PTHR23308:SF36 NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1 SMAD NUCLEAR-INTERACTING PROTEIN 1 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147 TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282 HELRO|EnsemblGenome=HelroG116663|UniProtKB=T1EGG9 T1EGG9 20195671 PTHR13414:SF9 HUEL-CATION TRANSPORTER PROTON-COUPLED ZINC ANTIPORTER SLC30A9, MITOCHONDRIAL transporter#PC00227 HELRO|EnsemblGenome=HelroG166253|UniProtKB=T1EXY1 T1EXY1 20201431 PTHR44755:SF11 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED ATRIAL NATRIURETIC PEPTIDE RECEPTOR 3 ISOFORM X1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide hormone binding#GO:0017046;hormone binding#GO:0042562;binding#GO:0005488;peptide binding#GO:0042277;amide binding#GO:0033218 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG179855|UniProtKB=T1FF76 T1FF76 20207475 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG127771|UniProtKB=T1EHH7 T1EHH7 20196027 PTHR11193:SF0 SMALL NUCLEAR RIBONUCLEOPROTEIN E SMALL NUCLEAR RIBONUCLEOPROTEIN E cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;spliceosomal snRNP assembly#GO:0000387;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;U4/U6 x U5 tri-snRNP complex#GO:0046540;U1 snRNP#GO:0005685;cellular anatomical entity#GO:0110165;organelle#GO:0043226;U4 snRNP#GO:0005687;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;U5 snRNP#GO:0005682;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;pICln-Sm protein complex#GO:0034715;protein-containing complex#GO:0032991;U2 snRNP#GO:0005686;spliceosomal tri-snRNP complex#GO:0097526;precatalytic spliceosome#GO:0071011;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG182401|UniProtKB=T1FI52 T1FI52 20208501 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cell communication#GO:0007154;cellular process#GO:0009987;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;Notch signaling pathway#GO:0007219 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG192533|UniProtKB=T1FU22 T1FU22 20212318 PTHR12656:SF5 BRG-1 ASSOCIATED FACTOR 250 BAF250 TRITHORAX GROUP PROTEIN OSA nucleosome binding#GO:0031491;protein-containing complex binding#GO:0044877;binding#GO:0005488;chromatin binding#GO:0003682 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;SWI/SNF complex#GO:0016514;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG161456|UniProtKB=T1ERH5 T1ERH5 20199175 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG72943|UniProtKB=T1G175 T1G175 20214823 PTHR12300:SF117 HVA22-LIKE PROTEINS LP05237P-RELATED membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG76435|UniProtKB=T1G2J8 T1G2J8 20215296 PTHR13703:SF45 SMAD MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG cis-regulatory region sequence-specific DNA binding#GO:0000987;SMAD binding#GO:0046332;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;protein binding#GO:0005515;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 signal transduction#GO:0007165;regulation of nitrogen compound metabolic process#GO:0051171;response to growth factor#GO:0070848;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;cellular response to BMP stimulus#GO:0071773;cell differentiation#GO:0030154;response to endogenous stimulus#GO:0009719;anatomical structure morphogenesis#GO:0009653;regulation of biosynthetic process#GO:0009889;response to BMP#GO:0071772;regulation of macromolecule biosynthetic process#GO:0010556;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;regulation of gene expression#GO:0010468;signaling#GO:0023052;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;cellular response to endogenous stimulus#GO:0071495;regulation of DNA-templated transcription#GO:0006355;BMP signaling pathway#GO:0030509;cell communication#GO:0007154;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;cellular response to growth factor stimulus#GO:0071363;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;cell surface receptor signaling pathway#GO:0007166;anatomical structure development#GO:0048856;transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0007178;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 MYO signaling pathway#P06215>MED#P06311;DPP signaling pathway#P06213>MED#P06279;DPP-SCW signaling pathway#P06212>MED#P06265;SCW signaling pathway#P06216>MED#P06323;Activin beta signaling pathway#P06210>MED#P06233;BMP/activin signaling pathway-drosophila#P06211>Co-Smad#P06254;TGF-beta signaling pathway#P00052>Co-Smads#P01276;TGF-beta signaling pathway#P00052>RSmads#P01292;ALP23B signaling pathway#P06209>MED#P06221;GBB signaling pathway#P06214>MED#P06299 HELRO|EnsemblGenome=HelroG72557|UniProtKB=T1G117 T1G117 20214765 PTHR12176:SF80 SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN EEF1A LYSINE METHYLTRANSFERASE 4 methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG86050|UniProtKB=T1G666 T1G666 20216563 PTHR45638:SF7 CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A CYCLIC NUCLEOTIDE-GATED ION CHANNEL-LIKE, ISOFORM E protein-containing complex binding#GO:0044877;binding#GO:0005488 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG103204|UniProtKB=T1EDF0 T1EDF0 20194602 PTHR20886:SF11 VANG-LIKE PROTEIN VANG-LIKE PROTEIN signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;epithelium development#GO:0060429;non-canonical Wnt signaling pathway#GO:0035567;developmental process#GO:0032502;cell communication#GO:0007154;cellular process#GO:0009987;cell-cell signaling by wnt#GO:0198738;tissue development#GO:0009888;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;anatomical structure morphogenesis#GO:0009653;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;tissue morphogenesis#GO:0048729;morphogenesis of an epithelium#GO:0002009;cell-cell signaling#GO:0007267;signaling#GO:0023052;Wnt signaling pathway#GO:0016055 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG180536|UniProtKB=T1FG13 T1FG13 20207762 PTHR46007:SF8 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 C2H2-TYPE DOMAIN-CONTAINING PROTEIN molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;protein binding#GO:0005515;transcription factor binding#GO:0008134 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG189847|UniProtKB=T1FRF2 T1FRF2 20211399 PTHR46007:SF8 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 C2H2-TYPE DOMAIN-CONTAINING PROTEIN molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;protein binding#GO:0005515;transcription factor binding#GO:0008134 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG165334|UniProtKB=T1EWL7 T1EWL7 20200967 PTHR23320:SF142 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MARVEL DOMAIN-CONTAINING PROTEIN transporter#PC00227 HELRO|EnsemblGenome=HelroG172909|UniProtKB=T1F643 T1F643 20204292 PTHR11905:SF159 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185580|UniProtKB=T1FN02 T1FN02 20210201 PTHR44313:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 17 DNAJ HOMOLOG SUBFAMILY C MEMBER 17 cellular aromatic compound metabolic process#GO:0006725;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;mRNA metabolic process#GO:0016071;cellular component disassembly#GO:0022411;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;protein-containing complex disassembly#GO:0032984;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG88805|UniProtKB=T1G767 T1G767 20216914 PTHR10068:SF14 BONE MARROW PROTEOGLYCAN CELL WALL ADHESIN EAP1 extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG172590|UniProtKB=T1F5K4 T1F5K4 20204103 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169987|UniProtKB=T1F2I0 T1F2I0 20203030 PTHR21049:SF0 RIBOPHORIN I DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;protein metabolic process#GO:0019538;protein N-linked glycosylation via asparagine#GO:0018279;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 membrane protein complex#GO:0098796;endoplasmic reticulum protein-containing complex#GO:0140534;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;oligosaccharyltransferase complex#GO:0008250;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG186550|UniProtKB=T1FP10 T1FP10 20210557 PTHR19920:SF0 WD40 PROTEIN CIAO1 CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;iron-sulfur cluster assembly#GO:0016226;cellular component organization#GO:0016043;cellular process#GO:0009987 protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535 HELRO|EnsemblGenome=HelroG162328|UniProtKB=T1ESI5 T1ESI5 20199535 PTHR10217:SF435 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EAG monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG157054|UniProtKB=T1EM55 T1EM55 20197655 PTHR13292:SF0 AUTOPHAGY-RELATED PROTEIN 101 AUTOPHAGY-RELATED PROTEIN 101 enzyme binding#GO:0019899;protein binding#GO:0005515;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;macroautophagy#GO:0016236;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular process#GO:0009987;organelle assembly#GO:0070925;process utilizing autophagic mechanism#GO:0061919;cellular component organization or biogenesis#GO:0071840;vacuole organization#GO:0007033;organelle organization#GO:0006996;catabolic process#GO:0009056;autophagosome assembly#GO:0000045;autophagy#GO:0006914;metabolic process#GO:0008152;cellular catabolic process#GO:0044248 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;phagophore assembly site#GO:0000407;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695 HELRO|EnsemblGenome=HelroG94572|UniProtKB=T1G918 T1G918 20217565 PTHR11647:SF1 HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER COLLAPSIN RESPONSE MEDIATOR PROTEIN metabolite interconversion enzyme#PC00262;hydrolase#PC00121 Axon guidance mediated by semaphorins#P00007>CRMP#P00339;Pyrimidine Metabolism#P02771>Dihydropyrimidinase#P03125 HELRO|EnsemblGenome=HelroG176975|UniProtKB=T1FB31 T1FB31 20206030 PTHR11909:SF18 CASEIN KINASE-RELATED CASEIN KINASE I ISOFORM DELTA non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;CCKR signaling map#P06959>CK1delta/epsilon#P07089;Circadian clock system#P00015>Casein kinase I#P00502;Parkinson disease#P00049>Casein kinase I#P01242 HELRO|EnsemblGenome=HelroG176569|UniProtKB=T1FAN8 T1FAN8 20205887 PTHR11893:SF36 INNEXIN INNEXIN-5 cell junction protein#PC00070;gap junction#PC00105 HELRO|EnsemblGenome=HelroG191777|UniProtKB=T1FTB3 T1FTB3 20212060 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182953|UniProtKB=T1FIZ3 T1FIZ3 20208792 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED single-stranded RNA binding#GO:0003727;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;poly(A) binding#GO:0008143;binding#GO:0005488;organic cyclic compound binding#GO:0097159 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG156859|UniProtKB=T1EM20 T1EM20 20197620 PTHR22957:SF26 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN LD44506P nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;activation of GTPase activity#GO:0090630;biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG133479|UniProtKB=T1EI11 T1EI11 20196211 PTHR24416:SF564 TYROSINE-PROTEIN KINASE RECEPTOR MACROPHAGE-STIMULATING PROTEIN RECEPTOR signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;nervous system development#GO:0007399;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;system development#GO:0048731;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cell motility#GO:0048870;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;cell migration#GO:0016477;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG109176|UniProtKB=T1EER0 T1EER0 20195062 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;heme binding#GO:0020037 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG77129|UniProtKB=T1G2T4 T1G2T4 20215382 PTHR12778:SF9 SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED ACETYL-COENZYME A TRANSPORTER 1 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG194111|UniProtKB=T1FVP6 T1FVP6 20212892 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG91450|UniProtKB=T1G839 T1G839 20217236 PTHR24416:SF525 TYROSINE-PROTEIN KINASE RECEPTOR INSULIN-LIKE RECEPTOR signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Insulin/IGF pathway-protein kinase B signaling cascade#P00033>INSR IGF-R IRR#P00895;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>INSR IGF-R IRR#P00885;PI3 kinase pathway#P00048>IR#P01187;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>Insulin IGF#P00882 HELRO|EnsemblGenome=HelroG160322|UniProtKB=T1EQ36 T1EQ36 20198686 PTHR24135:SF28 SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN LD13733P scaffold/adaptor protein#PC00226 Ionotropic glutamate receptor pathway#P00037>PSD95#P00999 HELRO|EnsemblGenome=HelroG182865|UniProtKB=T1FIW2 T1FIW2 20208761 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193530|UniProtKB=T1FV33 T1FV33 20212679 PTHR24253:SF153 TRANSMEMBRANE PROTEASE SERINE SERINE PROTEASE HEPSIN serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG156842|UniProtKB=T1EM17 T1EM17 20197617 PTHR19229:SF250 ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;lipid transporter activity#GO:0005319;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;organic substance transport#GO:0071702;lipid localization#GO:0010876;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;lipid transport#GO:0006869;transport#GO:0006810 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG70010|UniProtKB=T1G015 T1G015 20214413 PTHR24096:SF149 LONG-CHAIN-FATTY-ACID--COA LIGASE AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED ligase activity#GO:0016874;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 metabolite interconversion enzyme#PC00262;ligase#PC00142 HELRO|EnsemblGenome=HelroG191579|UniProtKB=T1FT36 T1FT36 20211983 PTHR23277:SF108 NECTIN-RELATED FASCICLIN-3 cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules#GO:0007157;cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156 cell junction#GO:0030054;adherens junction#GO:0005912;cellular anatomical entity#GO:0110165;cell-cell junction#GO:0005911;anchoring junction#GO:0070161 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG75815|UniProtKB=T1G2A6 T1G2A6 20215204 PTHR10784:SF0 TRANSLATION INITIATION FACTOR 6 EUKARYOTIC TRANSLATION INITIATION FACTOR 6 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;ribosomal large subunit biogenesis#GO:0042273;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;ribosomal large subunit assembly#GO:0000027;ribosome biogenesis#GO:0042254;non-membrane-bounded organelle assembly#GO:0140694;maturation of 5.8S rRNA#GO:0000460;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;protein-RNA complex organization#GO:0071826;maturation of LSU-rRNA#GO:0000470 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG192960|UniProtKB=T1FUG5 T1FUG5 20212461 PTHR13780:SF35 AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT LD22662P kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG80798|UniProtKB=T1G456 T1G456 20215854 PTHR24044:SF504 NOTCH LIGAND FAMILY MEMBER EGF-LIKE DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 regulation of cell communication#GO:0010646;signal transduction#GO:0007165;negative regulation of biological process#GO:0048519;cellular response to stimulus#GO:0051716;negative regulation of response to stimulus#GO:0048585;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;cell communication#GO:0007154;cellular process#GO:0009987;negative regulation of Notch signaling pathway#GO:0045746;regulation of Notch signaling pathway#GO:0008593;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of cell communication#GO:0010648;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;Notch signaling pathway#GO:0007219 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG166969|UniProtKB=T1EYT9 T1EYT9 20201739 PTHR47055:SF3 DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 HELRO|EnsemblGenome=HelroG173035|UniProtKB=T1F6A4 T1F6A4 20204353 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG193089|UniProtKB=T1FUM0 T1FUM0 20212516 PTHR22594:SF5 ASPARTYL/LYSYL-TRNA SYNTHETASE ASPARTATE--TRNA LIGASE, MITOCHONDRIAL catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG177209|UniProtKB=T1FBC8 T1FBC8 20206127 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG117203|UniProtKB=T1EGL0 T1EGL0 20195710 PTHR22973:SF12 LD35087P LD35087P cytoplasm#GO:0005737;bounding membrane of organelle#GO:0098588;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185481|UniProtKB=T1FMV7 T1FMV7 20210156 PTHR11530:SF11 D-AMINO ACID OXIDASE D-ASPARTATE OXIDASE oxidase#PC00175;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG76057|UniProtKB=T1G2E4 T1G2E4 20215242 PTHR10736:SF0 BESTROPHIN BESTROPHIN HOMOLOG ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG151477|UniProtKB=T1EKK6 T1EKK6 20197106 PTHR15698:SF10 PROTEIN CBG15099 PHYTANOYL-COA HYDROXYLASE-INTERACTING PROTEIN-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164847|UniProtKB=T1EVV9 T1EVV9 20200709 PTHR10972:SF205 OXYSTEROL-BINDING PROTEIN-RELATED OXYSTEROL-BINDING PROTEIN 1 binding#GO:0005488;organic cyclic compound binding#GO:0097159;steroid binding#GO:0005496;sterol transporter activity#GO:0015248;sterol binding#GO:0032934;lipid binding#GO:0008289;lipid transporter activity#GO:0005319;transporter activity#GO:0005215 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG77874|UniProtKB=T1G351 T1G351 20215499 PTHR24241:SF117 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;binding#GO:0005488;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888;amide binding#GO:0033218 response to organic substance#GO:0010033;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;response to hormone#GO:0009725;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG68139|UniProtKB=T1FZA8 T1FZA8 20214156 PTHR10083:SF381 KUNITZ-TYPE PROTEASE INHIBITOR-RELATED BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN peptidase inhibitor activity#GO:0030414;molecular function regulator activity#GO:0098772;serine-type endopeptidase inhibitor activity#GO:0004867;peptidase regulator activity#GO:0061134;enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;endopeptidase regulator activity#GO:0061135;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG194341|UniProtKB=T1FVY4 T1FVY4 20212980 PTHR10417:SF15 GLUCOCORTICOID MODULATORY ELEMENT-BINDING PROTEIN STERILE ALPHA MOTIF DOMAIN-CONTAINING 11 HELRO|EnsemblGenome=HelroG182600|UniProtKB=T1FIG1 T1FIG1 20208610 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG156827|UniProtKB=T1EM16 T1EM16 20197616 PTHR11758:SF16 40S RIBOSOMAL PROTEIN S15A 40S RIBOSOMAL PROTEIN S15A structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;small ribosomal subunit#GO:0015935;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG182427|UniProtKB=T1FI65 T1FI65 20208514 PTHR22950:SF349 AMINO ACID TRANSPORTER AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN L-amino acid transmembrane transporter activity#GO:0015179;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171;organic anion transmembrane transporter activity#GO:0008514;organic acid transmembrane transporter activity#GO:0005342;transporter activity#GO:0005215 localization#GO:0051179;organic substance transport#GO:0071702;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;organic anion transport#GO:0015711;amino acid transport#GO:0006865;organic acid transport#GO:0015849;transport#GO:0006810;nitrogen compound transport#GO:0071705;organic acid transmembrane transport#GO:1903825;carboxylic acid transport#GO:0046942;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuolar membrane#GO:0005774;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 amino acid transporter#PC00046;transporter#PC00227 HELRO|EnsemblGenome=HelroG180362|UniProtKB=T1FFU0 T1FFU0 20207689 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189324|UniProtKB=T1FQY4 T1FQY4 20211231 PTHR24161:SF124 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED TRANSIENT RECEPTOR POTENTIAL CHANNEL PYREXIA protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG192181|UniProtKB=T1FTN7 T1FTN7 20212184 PTHR22951:SF5 CLATHRIN ASSEMBLY PROTEIN PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP phosphatidylinositol bisphosphate binding#GO:1902936;small molecule binding#GO:0036094;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;binding#GO:0005488;protein binding#GO:0005515;clathrin binding#GO:0030276;lipid binding#GO:0008289;ion binding#GO:0043167;anion binding#GO:0043168;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981;SNARE binding#GO:0000149 localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;vesicle budding from membrane#GO:0006900;establishment of localization#GO:0051234;membrane organization#GO:0061024;organelle organization#GO:0006996;clathrin-dependent endocytosis#GO:0072583;transport#GO:0006810;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;vesicle organization#GO:0016050;cellular component organization#GO:0016043;receptor-mediated endocytosis#GO:0006898;cellular process#GO:0009987;import into cell#GO:0098657 cytoplasm#GO:0005737;clathrin-coated vesicle#GO:0030136;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;clathrin-coated pit#GO:0005905;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG177702|UniProtKB=T1FC38 T1FC38 20206387 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157577|UniProtKB=T1EMD4 T1EMD4 20197734 PTHR11239:SF1 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9 catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;RNA polymerase activity#GO:0097747;transferase activity, transferring phosphorus-containing groups#GO:0016772 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;RNA metabolic process#GO:0016070;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;transcription initiation at RNA polymerase II promoter#GO:0006367;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;transcription elongation by RNA polymerase II#GO:0006368;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;nucleotide-excision repair#GO:0006289;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;DNA-templated transcription elongation#GO:0006354;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;cellular response to stress#GO:0033554;transcription by RNA polymerase II#GO:0006366;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;RNA polymerase II, core complex#GO:0005665;organelle lumen#GO:0043233;nucleus#GO:0005634;DNA-directed RNA polymerase complex#GO:0000428;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nucleoplasm#GO:0005654;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388 HELRO|EnsemblGenome=HelroG153345|UniProtKB=T1EL46 T1EL46 20197296 PTHR46289:SF17 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180282|UniProtKB=T1FFP1 T1FFP1 20207640 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cell communication#GO:0007154;cellular process#GO:0009987;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;Notch signaling pathway#GO:0007219 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG192651|UniProtKB=T1FU57 T1FU57 20212353 PTHR31434:SF2 S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM HELRO|EnsemblGenome=HelroG82136|UniProtKB=T1G4N4 T1G4N4 20216032 PTHR14208:SF2 BASIC LEUCINE ZIPPER AND W2 DOMAIN-CONTAINING PROTEIN PROTEIN KRASAVIETZ cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 basic leucine zipper transcription factor#PC00056 HELRO|EnsemblGenome=HelroG177463|UniProtKB=T1FBQ5 T1FBQ5 20206254 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG163509|UniProtKB=T1EU55 T1EU55 20200105 PTHR45828:SF45 CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE REELIN DOMAIN-CONTAINING PROTEIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 reductase#PC00198;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG154743|UniProtKB=T1ELF8 T1ELF8 20197408 PTHR44942:SF4 METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165635|UniProtKB=T1EX38 T1EX38 20201138 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER FI01427P membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG194468|UniProtKB=T1FW32 T1FW32 20213028 PTHR11814:SF257 SULFATE TRANSPORTER ANION TRANSPORTER SULP-7D inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;organic acid transmembrane transporter activity#GO:0005342;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;organic anion transmembrane transporter activity#GO:0008514;inorganic anion transmembrane transporter activity#GO:0015103;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG89692|UniProtKB=T1G7G0 T1G7G0 20217007 PTHR12263:SF0 VACUOLAR ATP SYNTHASE SUBUNIT H V-TYPE PROTON ATPASE SUBUNIT localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 ATP synthase#PC00002;transporter#PC00227 HELRO|EnsemblGenome=HelroG75114|UniProtKB=T1G210 T1G210 20215108 PTHR11566:SF67 DYNAMIN DYNAMIN-LIKE 120 KDA PROTEIN, MITOCHONDRIAL GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;microtubule binding#GO:0008017;ribonucleoside triphosphate phosphatase activity#GO:0017111 mitochondrial fusion#GO:0008053;organelle localization#GO:0051640;transport#GO:0006810;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;organelle organization#GO:0006996;organelle fission#GO:0048285;mitochondrion organization#GO:0007005;peroxisome organization#GO:0007031;import into cell#GO:0098657;mitochondrial fission#GO:0000266;organelle fusion#GO:0048284 envelope#GO:0031975;membrane-enclosed lumen#GO:0031974;supramolecular complex#GO:0099080;mitochondrial membrane#GO:0031966;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;organelle membrane#GO:0031090;supramolecular polymer#GO:0099081;mitochondrion#GO:0005739;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;mitochondrial envelope#GO:0005740;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;mitochondrial intermembrane space#GO:0005758;cytoskeleton#GO:0005856;microtubule#GO:0005874 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG181542|UniProtKB=T1FH32 T1FH32 20208131 PTHR22765:SF405 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE RNF128 PRECURSOR transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG178469|UniProtKB=T1FD77 T1FD77 20206776 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG194106|UniProtKB=T1FVP3 T1FVP3 20212889 PTHR45734:SF10 TENSIN BLISTERY, ISOFORM A cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG171387|UniProtKB=T1F479 T1F479 20203628 PTHR47510:SF3 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG134995|UniProtKB=T1EI66 T1EI66 20196266 PTHR19288:SF46 4-NITROPHENYLPHOSPHATASE-RELATED HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG188811|UniProtKB=T1FQE1 T1FQE1 20211038 PTHR21551:SF0 TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1 PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159 negative regulation of gene expression#GO:0010629;cellular component biogenesis#GO:0044085;regulation of catabolic process#GO:0009894;heterocycle catabolic process#GO:0046700;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;nucleobase-containing compound metabolic process#GO:0006139;RNA destabilization#GO:0050779;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;regulation of biological quality#GO:0065008;nitrogen compound metabolic process#GO:0006807;P-body assembly#GO:0033962;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;cellular component assembly#GO:0022607;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;cellular component organization or biogenesis#GO:0071840;positive regulation of mRNA catabolic process#GO:0061014;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of catabolic process#GO:0009896;mRNA destabilization#GO:0061157;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323;positive regulation of nitrogen compound metabolic process#GO:0051173;cellular aromatic compound metabolic process#GO:0006725;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of mRNA stability#GO:0043488;regulation of mRNA catabolic process#GO:0061013;RNA metabolic process#GO:0016070;positive regulation of cellular catabolic process#GO:0031331;cellular nitrogen compound catabolic process#GO:0044270;RNA decapping#GO:0110154;positive regulation of metabolic process#GO:0009893;organic cyclic compound metabolic process#GO:1901360;mRNA catabolic process#GO:0006402;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;regulation of macromolecule biosynthetic process#GO:0010556;non-membrane-bounded organelle assembly#GO:0140694;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;positive regulation of mRNA metabolic process#GO:1903313;heterocycle metabolic process#GO:0046483;negative regulation of biosynthetic process#GO:0009890;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of cellular catabolic process#GO:0031329;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;organelle assembly#GO:0070925;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;organelle organization#GO:0006996;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;positive regulation of RNA metabolic process#GO:0051254 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;P-body#GO:0000932;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic ribonucleoprotein granule#GO:0036464 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG112321|UniProtKB=T1EFI6 T1EFI6 20195338 PTHR19376:SF11 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1 catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;RNA polymerase activity#GO:0097747;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;RNA polymerase I activity#GO:0001054 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;RNA polymerase I complex#GO:0005736;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG186165|UniProtKB=T1FNR3 T1FNR3 20210460 PTHR43450:SF1 ASPARTYL-TRNA SYNTHETASE ASPARTATE--TRNA LIGASE, CYTOPLASMIC catalytic activity, acting on RNA#GO:0140098;ligase activity#GO:0016874;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cytosol#GO:0005829;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG186088|UniProtKB=T1FNN1 T1FNN1 20210428 PTHR10849:SF20 NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL NADH dehydrogenase activity#GO:0003954;oxidoreductase activity, acting on NAD(P)H#GO:0016651;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cellular metabolic process#GO:0044237;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;cellular process#GO:0009987;energy derivation by oxidation of organic compounds#GO:0015980;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG168357|UniProtKB=T1F0G6 T1F0G6 20202316 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG187946|UniProtKB=T1FPH8 T1FPH8 20210725 PTHR19282:SF534 TETRASPANIN TETRASPANIN FAMILY-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG193541|UniProtKB=T1FV39 T1FV39 20212685 PTHR24351:SF230 RIBOSOMAL PROTEIN S6 KINASE RIBOSOMAL PROTEIN S6 KINASE transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;nitrogen compound metabolic process#GO:0006807;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 p53 pathway by glucose deprivation#P04397>S6K#P04636;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>P90 RSK#P00888;PDGF signaling pathway#P00047>p90RSK#P01142 HELRO|EnsemblGenome=HelroG171997|UniProtKB=T1F4X5 T1F4X5 20203874 PTHR24256:SF470 TRYPTASE-RELATED INACTIVE CLIP DOMAIN-CONTAINING SERINE PROTEASE A30 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG92804|UniProtKB=T1G8L3 T1G8L3 20217410 PTHR43907:SF1 SLEI FAMILY PROTEIN GH18 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177713|UniProtKB=T1FC45 T1FC45 20206394 PTHR48032:SF18 RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6 RRM DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG141779|UniProtKB=T1EJ42 T1EJ42 20196592 PTHR24204:SF8 INSULIN GENE ENHANCER PROTEIN TAILUP, ISOFORM A cellular developmental process#GO:0048869;neurogenesis#GO:0022008;cell projection organization#GO:0030030;multicellular organism development#GO:0007275;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;cell morphogenesis#GO:0000902;cellular component organization#GO:0016043;cell fate commitment#GO:0045165;cellular process#GO:0009987;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;cell fate specification#GO:0001708;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;cell differentiation#GO:0030154;system development#GO:0048731;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;neuron differentiation#GO:0030182;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;axonogenesis#GO:0007409;plasma membrane bounded cell projection morphogenesis#GO:0120039;generation of neurons#GO:0048699 HELRO|EnsemblGenome=HelroG173287|UniProtKB=T1F6N0 T1F6N0 20204479 PTHR15654:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 113-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN 113 organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 axoneme#GO:0005930;microtubule organizing center#GO:0005815;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;ciliary plasm#GO:0097014;plasma membrane bounded cell projection cytoplasm#GO:0032838;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG164427|UniProtKB=T1EVE6 T1EVE6 20200546 PTHR19359:SF150 CYTOCHROME B5 CYTOCHROME B5 tetrapyrrole binding#GO:0046906;binding#GO:0005488;organic cyclic compound binding#GO:0097159;heme binding#GO:0020037 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG155881|UniProtKB=T1ELN6 T1ELN6 20197486 PTHR10261:SF0 COATOMER SUBUNIT GAMMA COATOMER SUBUNIT GAMMA-2 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;intra-Golgi vesicle-mediated transport#GO:0006891;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;protein secretion#GO:0009306;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;establishment of protein localization to extracellular region#GO:0035592;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;secretion#GO:0046903;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;protein localization to extracellular region#GO:0071692;export from cell#GO:0140352;secretion by cell#GO:0032940 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;vesicle coat#GO:0030120;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;Golgi-associated vesicle membrane#GO:0030660;protein-containing complex#GO:0032991;COPI vesicle coat#GO:0030126;endomembrane system#GO:0012505;membrane coat#GO:0030117;coated vesicle membrane#GO:0030662;COPI-coated vesicle#GO:0030137;Golgi-associated vesicle#GO:0005798;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;coated membrane#GO:0048475;cytoplasmic vesicle membrane#GO:0030659;Golgi membrane#GO:0000139;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;endoplasmic reticulum#GO:0005783 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG173734|UniProtKB=T1F763 T1F763 20204662 PTHR10585:SF14 ER LUMEN PROTEIN RETAINING RECEPTOR ER LUMEN PROTEIN-RETAINING RECEPTOR signal sequence binding#GO:0005048;binding#GO:0005488;amide binding#GO:0033218;peptide binding#GO:0042277 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;protein localization to endoplasmic reticulum#GO:0070972;macromolecule localization#GO:0033036;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;protein localization#GO:0008104;localization#GO:0051179;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;maintenance of location#GO:0051235;maintenance of location in cell#GO:0051651;establishment of localization in cell#GO:0051649;protein localization to organelle#GO:0033365;intracellular transport#GO:0046907 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cis-Golgi network#GO:0005801;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG160837|UniProtKB=T1EQT0 T1EQT0 20198930 PTHR19269:SF45 TROPOMYOSIN TROPOMYOSIN-1, ISOFORMS 33_34 cytoskeletal protein#PC00085;actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG115999|UniProtKB=T1EGC5 T1EGC5 20195627 PTHR22727:SF15 PROTEIN CBG13728 MRH DOMAIN-CONTAINING PROTEIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG181060|UniProtKB=T1FGK4 T1FGK4 20207953 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162664|UniProtKB=T1ESZ4 T1ESZ4 20199694 PTHR20872:SF1 FAMILY NOT NAMED F-BOX DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172842|UniProtKB=T1F601 T1F601 20204250 PTHR19303:SF71 TRANSPOSON ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG194583|UniProtKB=T1FW79 T1FW79 20213075 PTHR23107:SF34 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN HTH LA-TYPE RNA-BINDING DOMAIN-CONTAINING PROTEIN transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG177999|UniProtKB=T1FCL0 T1FCL0 20206559 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG163664|UniProtKB=T1EUC1 T1EUC1 20200171 PTHR22948:SF29 TUDOR DOMAIN CONTAINING PROTEIN FI02030P-RELATED scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG186052|UniProtKB=T1FNL7 T1FNL7 20210414 PTHR35841:SF1 PHOSPHONATES-BINDING PERIPLASMIC PROTEIN PHOSPHONATES-BINDING PERIPLASMIC PROTEIN HELRO|EnsemblGenome=HelroG122743|UniProtKB=T1EGV5 T1EGV5 20195805 PTHR47023:SF1 SEX PEPTIDE RECEPTOR SEX PEPTIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG184897|UniProtKB=T1FM50 T1FM50 20209899 PTHR10333:SF42 INHIBITOR OF GROWTH PROTEIN INHIBITOR OF GROWTH PROTEIN 5 protein binding#GO:0005515;methylated histone binding#GO:0035064;binding#GO:0005488;histone binding#GO:0042393;modification-dependent protein binding#GO:0140030 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG74403|UniProtKB=T1G1Q5 T1G1Q5 20215003 PTHR14074:SF16 HELICASE WITH DEATH DOMAIN-RELATED ANTIVIRAL INNATE IMMUNE RESPONSE RECEPTOR RIG-I cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG186127|UniProtKB=T1FNP7 T1FNP7 20210444 PTHR15327:SF0 MICROFIBRIL-ASSOCIATED PROTEIN MICROFIBRILLAR-ASSOCIATED PROTEIN 1 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;U2-type spliceosomal complex#GO:0005684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG191035|UniProtKB=T1FSI9 T1FSI9 20211786 PTHR24416:SF527 TYROSINE-PROTEIN KINASE RECEPTOR PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;regulation of signaling#GO:0023051;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;regulation of signal transduction#GO:0009966;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cell communication#GO:0010646;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG177894|UniProtKB=T1FCF8 T1FCF8 20206507 PTHR46199:SF3 RAC GTPASE-ACTIVATING PROTEIN 1 RAC GTPASE-ACTIVATING PROTEIN 1 nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 cellular component biogenesis#GO:0044085;cell division#GO:0051301;signal transduction#GO:0007165;mitotic spindle organization#GO:0007052;small GTPase-mediated signal transduction#GO:0007264;nuclear division#GO:0000280;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;microtubule cytoskeleton organization involved in mitosis#GO:1902850;mitotic cell cycle process#GO:1903047;spindle elongation#GO:0051231;chromosome segregation#GO:0007059;regulation of biological process#GO:0050789;mitotic cytokinesis#GO:0000281;mitotic cell cycle#GO:0000278;mitotic spindle assembly#GO:0090307;cytoskeleton-dependent cytokinesis#GO:0061640;spindle assembly#GO:0051225;cytoskeleton organization#GO:0007010;mitotic nuclear division#GO:0140014;mitotic sister chromatid segregation#GO:0000070;spindle organization#GO:0007051;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;non-membrane-bounded organelle assembly#GO:0140694;cytokinesis#GO:0000910;signaling#GO:0023052;cellular component assembly#GO:0022607;nuclear chromosome segregation#GO:0098813;cellular response to stimulus#GO:0051716;sister chromatid segregation#GO:0000819;cell communication#GO:0007154;cellular component organization#GO:0016043;cellular process#GO:0009987;Rho protein signal transduction#GO:0007266;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;microtubule-based process#GO:0007017;organelle organization#GO:0006996;chromosome organization#GO:0051276;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell cycle#GO:0007049;organelle fission#GO:0048285 spindle midzone#GO:0051233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;mitotic spindle#GO:0072686;midbody#GO:0030496;microtubule cytoskeleton#GO:0015630;plasma membrane region#GO:0098590;membrane-bounded organelle#GO:0043227;cell division site#GO:0032153;cytoskeleton#GO:0005856;spindle#GO:0005819;plasma membrane#GO:0005886 G-protein modulator#PC00022;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG69117|UniProtKB=T1FZP8 T1FZP8 20214296 PTHR12566:SF12 CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB TRANSLATIONAL REGULATOR ORB2 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;translation regulator activity#GO:0045182;binding#GO:0005488;organic cyclic compound binding#GO:0097159;ribonucleoprotein complex binding#GO:0043021;ribosome binding#GO:0043022;mRNA binding#GO:0003729;protein-containing complex binding#GO:0044877;translation regulator activity, nucleic acid binding#GO:0090079;translation factor activity, RNA binding#GO:0008135;mRNA 3'-UTR binding#GO:0003730 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of protein metabolic process#GO:0051246;negative regulation of biosynthetic process#GO:0009890;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of translation#GO:0017148;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;synapse#GO:0045202;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;neuron projection#GO:0043005;cell junction#GO:0030054;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG188157|UniProtKB=T1FPQ0 T1FPQ0 20210797 PTHR13434:SF0 PROTEIN CASC3 PROTEIN CASC3 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG173390|UniProtKB=T1F6R6 T1F6R6 20204515 PTHR19288:SF93 4-NITROPHENYLPHOSPHATASE-RELATED FI11325P-RELATED hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG179244|UniProtKB=T1FEF2 T1FEF2 20207201 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG192792|UniProtKB=T1FUA9 T1FUA9 20212405 PTHR17608:SF4 GENETIC SUPPRESSOR ELEMENT 1 GENETIC SUPPRESSOR ELEMENT 1 HELRO|EnsemblGenome=HelroG74146|UniProtKB=T1G1M8 T1G1M8 20214976 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185669|UniProtKB=T1FN43 T1FN43 20210241 PTHR12561:SF3 LIPOATE-PROTEIN LIGASE LIPOYLTRANSFERASE 1, MITOCHONDRIAL transferase activity#GO:0016740;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;peptidyl-amino acid modification#GO:0018193;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG108605|UniProtKB=T1EEK8 T1EEK8 20195010 PTHR11920:SF501 GUANYLYL CYCLASE GUANYLATE CYCLASE 32E adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG193633|UniProtKB=T1FV77 T1FV77 20212723 PTHR44303:SF2 DNAJ HOMOLOG SUBFAMILY C MEMBER 16 DNAJ HOMOLOG SUBFAMILY C MEMBER 16 chaperone#PC00072 HELRO|EnsemblGenome=HelroG169832|UniProtKB=T1F2C9 T1F2C9 20202979 PTHR12395:SF9 DOM-3 RELATED DECAPPING AND EXORIBONUCLEASE PROTEIN catalytic activity, acting on RNA#GO:0140098;pyrophosphatase activity#GO:0016462;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;RNA decapping#GO:0110154;organic cyclic compound metabolic process#GO:1901360;mRNA catabolic process#GO:0006402;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;organic substance catabolic process#GO:1901575;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;nuclear-transcribed mRNA catabolic process#GO:0000956;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG186101|UniProtKB=T1FNN5 T1FNN5 20210432 PTHR11851:SF49 METALLOPROTEASE MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG112678|UniProtKB=T1EFL3 T1EFL3 20195365 PTHR13780:SF35 AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT LD22662P kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG116717|UniProtKB=T1EGH1 T1EGH1 20195673 PTHR11003:SF334 POTASSIUM CHANNEL, SUBFAMILY K FI03418P monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG183531|UniProtKB=T1FJS9 T1FJS9 20209078 PTHR24238:SF75 G-PROTEIN COUPLED RECEPTOR CHOLECYSTOKININ-LIKE RECEPTOR AT 17D1-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;neuropeptide signaling pathway#GO:0007218;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG62270|UniProtKB=T1FWY2 T1FWY2 20213330 PTHR11607:SF3 ALPHA-MANNOSIDASE LYSOSOMAL ALPHA-MANNOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 glycosidase#PC00110;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG180592|UniProtKB=T1FG27 T1FG27 20207776 PTHR24410:SF23 HL07962P-RELATED BTB DOMAIN-CONTAINING PROTEIN-RELATED defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG68312|UniProtKB=T1FZC9 T1FZC9 20214177 PTHR11626:SF2 FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE SQUALENE SYNTHASE prenyltransferase activity#GO:0004659;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;cellular metabolic process#GO:0044237;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;phospholipid metabolic process#GO:0006644;cellular lipid metabolic process#GO:0044255;isoprenoid metabolic process#GO:0006720;phosphorus metabolic process#GO:0006793;terpenoid metabolic process#GO:0006721;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 transferase#PC00220;metabolite interconversion enzyme#PC00262 Cholesterol biosynthesis#P00014>Farnesyl-diphosphate farnesyltransferase#P00499 HELRO|EnsemblGenome=HelroG181223|UniProtKB=T1FGR8 T1FGR8 20208017 PTHR47510:SF3 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG107164|UniProtKB=T1EE82 T1EE82 20194884 PTHR10574:SF375 NETRIN/LAMININ-RELATED LAMININ SUBUNIT BETA-1 neuron projection guidance#GO:0097485;cellular component biogenesis#GO:0044085;neurogenesis#GO:0022008;cell projection organization#GO:0030030;animal organ development#GO:0048513;developmental process#GO:0032502;substrate adhesion-dependent cell spreading#GO:0034446;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;extracellular matrix organization#GO:0030198;cellular anatomical entity morphogenesis#GO:0032989;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;external encapsulating structure organization#GO:0045229;neuron differentiation#GO:0030182;axonogenesis#GO:0007409;plasma membrane bounded cell projection morphogenesis#GO:0120039;cellular developmental process#GO:0048869;cellular component assembly#GO:0022607;multicellular organism development#GO:0007275;cell morphogenesis#GO:0000902;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cell motility#GO:0048870;cell-substrate adhesion#GO:0031589;cellular process#GO:0009987;tissue development#GO:0009888;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;extracellular structure organization#GO:0043062;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure development#GO:0048856;animal organ morphogenesis#GO:0009887;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;cell migration#GO:0016477 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;collagen-containing extracellular matrix#GO:0062023;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;basement membrane#GO:0005604 extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Laminin#P00947 HELRO|EnsemblGenome=HelroG112580|UniProtKB=T1EFK8 T1EFK8 20195360 PTHR48043:SF145 EG:EG0003.4 PROTEIN-RELATED FI06409P-RELATED HELRO|EnsemblGenome=HelroG172502|UniProtKB=T1F5F1 T1F5F1 20204050 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG86081|UniProtKB=T1G670 T1G670 20216567 PTHR46473:SF10 GH08155P LD45603P-RELATED HELRO|EnsemblGenome=HelroG192890|UniProtKB=T1FUE1 T1FUE1 20212437 PTHR23074:SF86 AAA DOMAIN-CONTAINING SPASTIN pyrophosphatase activity#GO:0016462;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG158709|UniProtKB=T1EN54 T1EN54 20198004 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG115498|UniProtKB=T1EG86 T1EG86 20195588 PTHR45820:SF4 FI23527P1 ZINC TRANSPORTER 63C, ISOFORM F inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075 inorganic ion homeostasis#GO:0098771;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;inorganic ion transmembrane transport#GO:0098660;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation transport#GO:0006812;transition metal ion transport#GO:0000041;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG156230|UniProtKB=T1ELT0 T1ELT0 20197530 PTHR32194:SF2 METALLOPROTEASE TLDD PROTEASOME SUBUNIT BETA TYPE-1 macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;catabolic process#GO:0009056;organonitrogen compound catabolic process#GO:1901565;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;proteasome complex#GO:0000502;endopeptidase complex#GO:1905369;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190 Parkinson disease#P00049>20S proteasome#P01227 HELRO|EnsemblGenome=HelroG182466|UniProtKB=T1FI87 T1FI87 20208536 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN SI:DKEY-17M8.2 HELRO|EnsemblGenome=HelroG168724|UniProtKB=T1F0W4 T1F0W4 20202464 PTHR46007:SF8 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 C2H2-TYPE DOMAIN-CONTAINING PROTEIN molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;protein binding#GO:0005515;transcription factor binding#GO:0008134 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG75798|UniProtKB=T1G2A4 T1G2A4 20215202 PTHR24250:SF67 CHYMOTRYPSIN-RELATED PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG175205|UniProtKB=T1F902 T1F902 20205301 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED BRCT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG109357|UniProtKB=T1EES7 T1EES7 20195079 PTHR11537:SF113 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;delayed rectifier potassium channel activity#GO:0005251;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG83308|UniProtKB=T1G539 T1G539 20216187 PTHR23359:SF105 NUCLEOTIDE KINASE ADENYLATE KINASE 7 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;nucleoside diphosphate kinase activity#GO:0004550;phosphotransferase activity, phosphate group as acceptor#GO:0016776;catalytic activity#GO:0003824;kinase activity#GO:0016301 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 nucleotide kinase#PC00172;kinase#PC00137 HELRO|EnsemblGenome=HelroG108140|UniProtKB=T1EEF8 T1EEF8 20194960 PTHR23123:SF35 PHD/F-BOX CONTAINING PROTEIN F-BOX_LRR-REPEAT PROTEIN 19 histone modifying activity#GO:0140993;molecular adaptor activity#GO:0060090;demethylase activity#GO:0032451;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;histone demethylase activity#GO:0032452;catalytic activity#GO:0003824;protein-macromolecule adaptor activity#GO:0030674;catalytic activity, acting on a protein#GO:0140096 macromolecule modification#GO:0043412;regulation of DNA-templated transcription#GO:0006355;macromolecule metabolic process#GO:0043170;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;protein metabolic process#GO:0019538;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG90647|UniProtKB=T1G7T8 T1G7T8 20217135 PTHR24204:SF8 INSULIN GENE ENHANCER PROTEIN TAILUP, ISOFORM A cellular developmental process#GO:0048869;neurogenesis#GO:0022008;cell projection organization#GO:0030030;multicellular organism development#GO:0007275;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;cell morphogenesis#GO:0000902;cellular component organization#GO:0016043;cell fate commitment#GO:0045165;cellular process#GO:0009987;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;cell fate specification#GO:0001708;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;cell differentiation#GO:0030154;system development#GO:0048731;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;neuron differentiation#GO:0030182;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;axonogenesis#GO:0007409;plasma membrane bounded cell projection morphogenesis#GO:0120039;generation of neurons#GO:0048699 HELRO|EnsemblGenome=HelroG187398|UniProtKB=T1FP96 T1FP96 20210643 PTHR10865:SF29 METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN METASTASIS ASSOCIATED 1-LIKE, ISOFORM D molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;histone deacetylase binding#GO:0042826;transcription corepressor activity#GO:0003714;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;enzyme binding#GO:0019899;protein binding#GO:0005515 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;chromatin#GO:0000785;nucleoplasm#GO:0005654;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;histone deacetylase complex#GO:0000118;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116 p53 pathway#P00059>MTA2#P04615 HELRO|EnsemblGenome=HelroG193524|UniProtKB=T1FV29 T1FV29 20212675 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG72643|UniProtKB=T1G132 T1G132 20214780 PTHR20855:SF15 ADIPOR/PROGESTIN RECEPTOR-RELATED PROGESTIN AND ADIPOQ RECEPTOR FAMILY MEMBER 3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG169542|UniProtKB=T1F226 T1F226 20202876 PTHR24026:SF51 FAT ATYPICAL CADHERIN-RELATED PROTOCADHERIN-LIKE WING POLARITY PROTEIN STAN cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987 cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HELRO|EnsemblGenome=HelroG101607|UniProtKB=T1ED57 T1ED57 20194509 PTHR11202:SF22 SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER PROTEIN ENABLED scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG176847|UniProtKB=T1FAY9 T1FAY9 20205988 PTHR12709:SF5 DNA-DIRECTED RNA POLYMERASE II, III DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;RNA metabolic process#GO:0016070;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;transcription by RNA polymerase I#GO:0006360;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;rRNA transcription#GO:0009303;nucleolar large rRNA transcription by RNA polymerase I#GO:0042790;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;transcription elongation by RNA polymerase I#GO:0006362;heterocycle metabolic process#GO:0046483;DNA-templated transcription elongation#GO:0006354;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;ncRNA transcription#GO:0098781;aromatic compound biosynthetic process#GO:0019438 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;RNA polymerase I complex#GO:0005736;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG71432|UniProtKB=T1G0L5 T1G0L5 20214613 PTHR23304:SF183 SPOT2-RELATED T. BRUCEI SPP.-SPECIFIC PROTEIN HELRO|EnsemblGenome=HelroG162948|UniProtKB=T1ETE6 T1ETE6 20199846 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG169148|UniProtKB=T1F1H0 T1F1H0 20202670 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190749|UniProtKB=T1FS94 T1FS94 20211691 PTHR46100:SF4 IMP2'P USPA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179938|UniProtKB=T1FF97 T1FF97 20207496 PTHR11675:SF119 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2 transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG67702|UniProtKB=T1FZ43 T1FZ43 20214091 PTHR24291:SF48 CYTOCHROME P450 FAMILY 4 CYTOCHROME P450 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG67887|UniProtKB=T1FZ70 T1FZ70 20214118 PTHR15614:SF2 INTRAFLAGELLAR TRANSPORT PROTEIN 81 HOMOLOG INTRAFLAGELLAR TRANSPORT PROTEIN 81 HOMOLOG cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 cilium organization#GO:0044782;cellular localization#GO:0051641;cell projection organization#GO:0030030;transport#GO:0006810;microtubule-based movement#GO:0007018;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;transport along microtubule#GO:0010970;intraciliary transport#GO:0042073;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;microtubule-based transport#GO:0099111;establishment of localization#GO:0051234;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;protein-containing complex localization#GO:0031503 microtubule organizing center#GO:0005815;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;intraciliary transport particle B#GO:0030992;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929;intraciliary transport particle#GO:0030990 HELRO|EnsemblGenome=HelroG172053|UniProtKB=T1F4Z3 T1F4Z3 20203892 PTHR13034:SF2 DYNACTIN P62 SUBUNIT DYNACTIN SUBUNIT 4 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG184446|UniProtKB=T1FL80 T1FL80 20209579 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG190910|UniProtKB=T1FSE8 T1FSE8 20211745 PTHR13309:SF0 NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1 FMR1-INTERACTING PROTEIN NUFIP1 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;protein-RNA complex assembly#GO:0022618;cellular component biogenesis#GO:0044085;protein-containing complex organization#GO:0043933;ribonucleoprotein complex biogenesis#GO:0022613;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;protein-RNA complex organization#GO:0071826;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG193907|UniProtKB=T1FVG8 T1FVG8 20212814 PTHR24093:SF369 CATION TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE calcium ion transmembrane transporter activity#GO:0015085;inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;P-type ion transporter activity#GO:0015662;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075 intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG73501|UniProtKB=T1G1E7 T1G1E7 20214895 PTHR13809:SF48 GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA-RELATED heterotrimeric G-protein#PC00117;G-protein#PC00020 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Gbetagamma#P00836;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GIRK#P00743;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047 HELRO|EnsemblGenome=HelroG179239|UniProtKB=T1FEE8 T1FEE8 20207197 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77812|UniProtKB=T1G344 T1G344 20215492 PTHR10663:SF388 GUANYL-NUCLEOTIDE EXCHANGE FACTOR GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG174703|UniProtKB=T1F8E0 T1F8E0 20205089 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG160492|UniProtKB=T1EQB2 T1EQB2 20198762 PTHR46786:SF1 ZINC FINGER MATRIN-TYPE PROTEIN 3 ZINC FINGER MATRIN-TYPE PROTEIN 3 RNA processing factor#PC00147 p53 pathway#P00059>PAG608#G04690 HELRO|EnsemblGenome=HelroG159077|UniProtKB=T1ENK2 T1ENK2 20198152 PTHR23236:SF25 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H RNA-BINDING PROTEIN 34 membrane-enclosed lumen#GO:0031974;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG164453|UniProtKB=T1EVF5 T1EVF5 20200555 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG133652|UniProtKB=T1EI21 T1EI21 20196221 PTHR24416:SF617 TYROSINE-PROTEIN KINASE RECEPTOR RET ONCOGENE, ISOFORM A signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG70743|UniProtKB=T1G0B6 T1G0B6 20214514 PTHR21274:SF0 MECKELIN MECKELIN organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cilium#GO:0005929;ciliary transition zone#GO:0035869 HELRO|EnsemblGenome=HelroG161476|UniProtKB=T1ERI4 T1ERI4 20199184 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG84530|UniProtKB=T1G5J8 T1G5J8 20216345 PTHR46241:SF1 ARMADILLO REPEAT-CONTAINING PROTEIN 4 ARMC4 OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 2 HELRO|EnsemblGenome=HelroG169449|UniProtKB=T1F1Y2 T1F1Y2 20202832 PTHR15868:SF0 SIMILAR TO RIKEN CDNA 6430571L13 GENE, SIMILAR TO G20 PROTEIN SIMILAR TO RIKEN CDNA 6430571L13 GENE_ SIMILAR TO G20 PROTEIN HELRO|EnsemblGenome=HelroG123698|UniProtKB=T1EGY5 T1EGY5 20195835 PTHR12892:SF17 FGF RECEPTOR ACTIVATING PROTEIN 1 POST-GPI ATTACHMENT TO PROTEINS FACTOR 2-LIKE lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;phospholipid biosynthetic process#GO:0008654;macromolecule modification#GO:0043412;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycolipid metabolic process#GO:0006664;protein modification process#GO:0036211;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;glycerolipid biosynthetic process#GO:0045017;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;organic substance biosynthetic process#GO:1901576;liposaccharide metabolic process#GO:1903509;cellular process#GO:0009987;GPI anchor metabolic process#GO:0006505;membrane lipid biosynthetic process#GO:0046467;lipoprotein biosynthetic process#GO:0042158;primary metabolic process#GO:0044238;GPI anchor biosynthetic process#GO:0006506;carbohydrate derivative biosynthetic process#GO:1901137;membrane lipid metabolic process#GO:0006643;glycerophospholipid biosynthetic process#GO:0046474;glycolipid biosynthetic process#GO:0009247;organophosphate metabolic process#GO:0019637;lipoprotein metabolic process#GO:0042157;cellular lipid metabolic process#GO:0044255 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185259|UniProtKB=T1FMK5 T1FMK5 20210054 PTHR18966:SF422 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED signaling receptor activity#GO:0038023;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;ligand-gated channel activity#GO:0022834 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019 HELRO|EnsemblGenome=HelroG156074|UniProtKB=T1ELR4 T1ELR4 20197514 PTHR24070:SF17 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY RAS-LIKE PROTEIN 2 GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 small GTPase#PC00208;G-protein#PC00020 TGF-beta signaling pathway#P00052>Ras-GDP#P01291;FGF signaling pathway#P00021>Ras#P00633;TGF-beta signaling pathway#P00052>Ras-GTP#P01280;PDGF signaling pathway#P00047>Ras#P01154;EGF receptor signaling pathway#P00018>Ras#P00552;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Ras#P00869;Ras Pathway#P04393>Ras#P04547;PI3 kinase pathway#P00048>Ras#P01182;p53 pathway feedback loops 2#P04398>Ras#P04651;Integrin signalling pathway#P00034>Ras#P00916 HELRO|EnsemblGenome=HelroG162846|UniProtKB=T1ET94 T1ET94 20199794 PTHR45816:SF4 MIR DOMAIN-CONTAINING PROTEIN RYR_IP3R HOMOLOGY ASSOCIATED DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183673|UniProtKB=T1FK08 T1FK08 20209157 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED BRCT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG64903|UniProtKB=T1FY09 T1FY09 20213707 PTHR43730:SF1 BETA-MANNOSIDASE BETA-MANNOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 carbohydrate derivative metabolic process#GO:1901135;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;carbohydrate derivative catabolic process#GO:1901136;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;catabolic process#GO:0009056;organonitrogen compound catabolic process#GO:1901565;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG166458|UniProtKB=T1EY56 T1EY56 20201506 PTHR15326:SF2 SPERMATOGENESIS-ASSOCIATED PROTEIN 2/TAMOZHENNIC PROTEIN TAMOZHENNIC HELRO|EnsemblGenome=HelroG106314|UniProtKB=T1EE18 T1EE18 20194820 PTHR19297:SF191 GLYCOSYLTRANSFERASE 14 FAMILY MEMBER PROTEIN XYLOSYLTRANSFERASE acetylglucosaminyltransferase activity#GO:0008375;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG116562|UniProtKB=T1EGG1 T1EGG1 20195663 PTHR43407:SF1 GLUTAMINE SYNTHETASE LENGSIN ligase activity#GO:0016874;catalytic activity#GO:0003824 proteinogenic amino acid biosynthetic process#GO:0170038;response to extracellular stimulus#GO:0009991;biosynthetic process#GO:0009058;cellular homeostasis#GO:0019725;carboxylic acid biosynthetic process#GO:0046394;nitrogen compound metabolic process#GO:0006807;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;L-amino acid metabolic process#GO:0170033;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;homeostatic process#GO:0042592;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;response to nutrient levels#GO:0031667;intracellular chemical homeostasis#GO:0055082;cellular process#GO:0009987;chemical homeostasis#GO:0048878;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;response to external stimulus#GO:0009605;response to stimulus#GO:0050896;alpha-amino acid biosynthetic process#GO:1901607;L-amino acid biosynthetic process#GO:0170034;small molecule biosynthetic process#GO:0044283;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 Glutamine glutamate conversion#P02745>Glutamine synthase#P04483;Glutamine glutamate conversion#P02745>Glutamine synthetase#P02968 HELRO|EnsemblGenome=HelroG83915|UniProtKB=T1G5B8 T1G5B8 20216265 PTHR47958:SF104 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE WM6 catalytic activity, acting on RNA#GO:0140098;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640;mRNA binding#GO:0003729 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG195104|UniProtKB=T1FWR3 T1FWR3 20213258 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG92025|UniProtKB=T1G8B4 T1G8B4 20217311 PTHR15722:SF7 IFT140/172-RELATED INTRAFLAGELLAR TRANSPORT PROTEIN 140 HOMOLOG cilium organization#GO:0044782;cellular localization#GO:0051641;cell projection organization#GO:0030030;transport#GO:0006810;microtubule-based movement#GO:0007018;cellular component organization#GO:0016043;intraciliary retrograde transport#GO:0035721;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;transport along microtubule#GO:0010970;intraciliary transport#GO:0042073;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;microtubule-based transport#GO:0099111;establishment of localization#GO:0051234;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;protein-containing complex localization#GO:0031503 axoneme#GO:0005930;microtubule organizing center#GO:0005815;intraciliary transport particle A#GO:0030991;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;ciliary plasm#GO:0097014;plasma membrane bounded cell projection cytoplasm#GO:0032838;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cytoskeleton#GO:0005856;cilium#GO:0005929;intraciliary transport particle#GO:0030990 structural protein#PC00211 HELRO|EnsemblGenome=HelroG100012|UniProtKB=T1ECY0 T1ECY0 20194432 PTHR10644:SF1 DNA REPAIR/RNA PROCESSING CPSF FAMILY SPLICING FACTOR 3B SUBUNIT 3 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;snRNA binding#GO:0017069;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;U2 snRNP#GO:0005686;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG165947|UniProtKB=T1EXH8 T1EXH8 20201278 PTHR12458:SF8 ORF PROTEIN CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20 regulation of microtubule-based process#GO:0032886;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;regulation of cell motility#GO:2000145;regulation of locomotion#GO:0040012;positive regulation of locomotion#GO:0040017;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;regulation of biological quality#GO:0065008;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;positive regulation of cell motility#GO:2000147;biological regulation#GO:0065007;plasma membrane bounded cell projection assembly#GO:0120031;positive regulation of biological process#GO:0048518 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;motile cilium#GO:0031514;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;cilium#GO:0005929;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 Transcription regulation by bZIP transcription factor#P00055>TFIIB#P01397;General transcription regulation#P00023>TFIIB#P00668 HELRO|EnsemblGenome=HelroG113490|UniProtKB=T1EFS8 T1EFS8 20195430 PTHR12548:SF9 TRANSCRIPTION FACTOR DP TRANSCRIPTION FACTOR DP sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG178025|UniProtKB=T1FCM4 T1FCM4 20206573 PTHR45692:SF1 G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG66958|UniProtKB=T1FYT8 T1FYT8 20213986 PTHR24410:SF41 HL07962P-RELATED HL07962P defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG163707|UniProtKB=T1EUD7 T1EUD7 20200187 PTHR11849:SF195 ETS GA-BINDING PROTEIN ALPHA CHAIN transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 PDGF signaling pathway#P00047>Ets#P01167 HELRO|EnsemblGenome=HelroG179051|UniProtKB=T1FE39 T1FE39 20207088 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG169836|UniProtKB=T1F2D0 T1F2D0 20202980 PTHR24403:SF112 ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG189487|UniProtKB=T1FR33 T1FR33 20211280 PTHR15995:SF1 PROTEIN ZWILCH HOMOLOG PROTEIN ZWILCH HOMOLOG negative regulation of sister chromatid segregation#GO:0033046;negative regulation of mitotic sister chromatid separation#GO:2000816;cellular localization#GO:0051641;negative regulation of biological process#GO:0048519;regulation of mitotic nuclear division#GO:0007088;signal transduction#GO:0007165;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;regulation of chromosome segregation#GO:0051983;macromolecule localization#GO:0033036;mitotic cell cycle checkpoint signaling#GO:0007093;negative regulation of chromosome organization#GO:2001251;regulation of chromosome separation#GO:1905818;negative regulation of mitotic nuclear division#GO:0045839;cell cycle process#GO:0022402;regulation of cellular component organization#GO:0051128;negative regulation of cell cycle process#GO:0010948;negative regulation of nuclear division#GO:0051784;negative regulation of mitotic sister chromatid segregation#GO:0033048;mitotic cell cycle process#GO:1903047;regulation of biological process#GO:0050789;cell cycle checkpoint signaling#GO:0000075;negative regulation of mitotic cell cycle phase transition#GO:1901991;mitotic cell cycle#GO:0000278;protein localization to kinetochore#GO:0034501;negative regulation of organelle organization#GO:0010639;regulation of mitotic sister chromatid segregation#GO:0033047;protein localization to organelle#GO:0033365;intracellular signal transduction#GO:0035556;negative regulation of cellular component organization#GO:0051129;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;regulation of chromosome organization#GO:0033044;cellular response to stimulus#GO:0051716;regulation of mitotic sister chromatid separation#GO:0010965;regulation of nuclear division#GO:0051783;negative regulation of cell cycle#GO:0045786;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of organelle organization#GO:0033043;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;mitotic spindle assembly checkpoint signaling#GO:0007094;negative regulation of chromosome segregation#GO:0051985;regulation of cell cycle phase transition#GO:1901987;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of mitotic cell cycle#GO:0045930;cell communication#GO:0007154;cellular process#GO:0009987;regulation of mitotic metaphase/anaphase transition#GO:0030071;regulation of cell cycle process#GO:0010564;protein localization#GO:0008104;localization#GO:0051179;response to stimulus#GO:0050896;cellular macromolecule localization#GO:0070727;negative regulation of chromosome separation#GO:1905819;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of sister chromatid segregation#GO:0033045;regulation of mitotic cell cycle#GO:0007346;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;kinetochore#GO:0000776;chromosome#GO:0005694;condensed chromosome, centromeric region#GO:0000779;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;chromosomal region#GO:0098687;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG84222|UniProtKB=T1G5G0 T1G5G0 20216307 PTHR23147:SF68 SERINE/ARGININE RICH SPLICING FACTOR SPLICING FACTOR, ARGININE_SERINE-RICH 2-RELATED nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;nuclear speck#GO:0016607;organelle#GO:0043226;nuclear body#GO:0016604;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG85571|UniProtKB=T1G5Z8 T1G5Z8 20216495 PTHR24256:SF470 TRYPTASE-RELATED INACTIVE CLIP DOMAIN-CONTAINING SERINE PROTEASE A30 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG163462|UniProtKB=T1EU30 T1EU30 20200080 PTHR24034:SF209 EGF-LIKE DOMAIN-CONTAINING PROTEIN EGF-LIKE DOMAIN-CONTAINING PROTEIN extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG167040|UniProtKB=T1EYX8 T1EYX8 20201778 PTHR39940:SF1 PROTHORACICOTROPIC HORMONE, ISOFORM F PROTHORACICOTROPIC HORMONE, ISOFORM F peptide hormone#PC00179 HELRO|EnsemblGenome=HelroG166464|UniProtKB=T1EY57 T1EY57 20201507 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG187742|UniProtKB=T1G8J7 T1G8J7 20217394 PTHR10484:SF162 HISTONE H4 HISTONE H4-LIKE PROTEIN TYPE G nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;nucleosome organization#GO:0034728;nucleosome assembly#GO:0006334;protein-containing complex organization#GO:0043933;protein-containing complex assembly#GO:0065003;chromatin organization#GO:0006325;cellular component organization#GO:0016043;cellular process#GO:0009987;chromatin remodeling#GO:0006338;protein-DNA complex assembly#GO:0065004 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG66349|UniProtKB=T1FYK0 T1FYK0 20213898 PTHR10037:SF230 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM CA[2+]-CHANNEL PROTEIN ALPHA[[1]] SUBUNIT T, ISOFORM F calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;voltage-gated channel activity#GO:0022832;sodium ion transmembrane transporter activity#GO:0015081;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated calcium channel activity#GO:0005245;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 localization#GO:0051179;calcium ion import#GO:0070509;metal ion transport#GO:0030001;establishment of localization#GO:0051234;regulation of biological quality#GO:0065008;membrane depolarization#GO:0051899;transport#GO:0006810;regulation of membrane potential#GO:0042391;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;action potential#GO:0001508;monoatomic ion transport#GO:0006811;calcium ion transport#GO:0006816 membrane protein complex#GO:0098796;sodium channel complex#GO:0034706;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron projection#GO:0043005;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell projection#GO:0042995;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG120014|UniProtKB=T1EGP2 T1EGP2 20195742 PTHR12305:SF81 PHOSPHATASE WITH HOMOLOGY TO TENSIN PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 cellular metabolic process#GO:0044237;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;metabolic process#GO:0008152;phosphate-containing compound metabolic process#GO:0006796;dephosphorylation#GO:0016311 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 p53 pathway#P00059>PTEN#G01579;p53 pathway feedback loops 2#P04398>PTEN#G04714;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PTEN#P00905;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PTEN#G04675;p53 pathway#P00059>PTEN#P01480;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PTEN#P00849;Hypoxia response via HIF activation#P00030>PTEN#P00824;PI3 kinase pathway#P00048>PTEN#P01189;CCKR signaling map#P06959>PTEN#P07071;p53 pathway feedback loops 2#P04398>PTEN#P04658 HELRO|EnsemblGenome=HelroG191487|UniProtKB=T1FT11 T1FT11 20211958 PTHR35193:SF5 MUCIN 13A, CELL SURFACE-ASSOCIATED-RELATED FLOCCULATION PROTEIN FLO11 HELRO|EnsemblGenome=HelroG182236|UniProtKB=T1FHZ1 T1FHZ1 20208440 PTHR24193:SF126 ANKYRIN REPEAT PROTEIN INVERSIN-LIKE sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG139475|UniProtKB=T1EIY9 T1EIY9 20196539 PTHR24083:SF4 NUCLEAR HORMONE RECEPTOR PHOTORECEPTOR-SPECIFIC NUCLEAR RECEPTOR cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;signaling receptor activity#GO:0038023;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG182799|UniProtKB=T1FIR7 T1FIR7 20208716 PTHR46601:SF1 ULP_PROTEASE DOMAIN-CONTAINING PROTEIN ADF-H DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157839|UniProtKB=T1EMG7 T1EMG7 20197767 PTHR10666:SF173 UBIQUITIN NEDD8 enzyme binding#GO:0019899;protein binding#GO:0005515;ubiquitin protein ligase binding#GO:0031625;binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389 protein neddylation#GO:0045116;regulation of proteolysis#GO:0030162;macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;regulation of protein metabolic process#GO:0051246;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;regulation of nitrogen compound metabolic process#GO:0051171;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;modification-dependent macromolecule catabolic process#GO:0043632;regulation of primary metabolic process#GO:0080090;regulation of macromolecule metabolic process#GO:0060255;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;biological regulation#GO:0065007;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;regulation of metabolic process#GO:0019222;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG126004|UniProtKB=T1EH81 T1EH81 20195931 PTHR11849:SF191 ETS ECDYSONE-INDUCED PROTEIN 74EF ISOFORM B transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 PDGF signaling pathway#P00047>Ets#P01167 HELRO|EnsemblGenome=HelroG65246|UniProtKB=T1FY50 T1FY50 20213748 PTHR10535:SF0 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1 catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;RNA polymerase activity#GO:0097747;transferase activity, transferring phosphorus-containing groups#GO:0016772;RNA polymerase III activity#GO:0001056;RNA polymerase II activity#GO:0001055;RNA polymerase I activity#GO:0001054 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;DNA-templated transcription#GO:0006351;RNA metabolic process#GO:0016070;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;transcription by RNA polymerase I#GO:0006360;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;rRNA transcription#GO:0009303;nucleolar large rRNA transcription by RNA polymerase I#GO:0042790;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;transcription elongation by RNA polymerase I#GO:0006362;heterocycle metabolic process#GO:0046483;transcription by RNA polymerase III#GO:0006383;DNA-templated transcription elongation#GO:0006354;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;ncRNA transcription#GO:0098781;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366 membrane-enclosed lumen#GO:0031974;RNA polymerase II, core complex#GO:0005665;organelle lumen#GO:0043233;nucleus#GO:0005634;DNA-directed RNA polymerase complex#GO:0000428;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nucleoplasm#GO:0005654;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;RNA polymerase II, holoenzyme#GO:0016591;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;RNA polymerase III complex#GO:0005666;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;RNA polymerase I complex#GO:0005736;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388;General transcription regulation#P00023>RNA Polymerase II#P00660 HELRO|EnsemblGenome=HelroG85315|UniProtKB=T1G5V3 T1G5V3 20216450 PTHR28511:SF1 ENDONUCLEASE V ENDONUCLEASE V catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;single-stranded RNA binding#GO:0003727;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;nuclease activity#GO:0004518;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;endonuclease activity#GO:0004519;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521 HELRO|EnsemblGenome=HelroG83805|UniProtKB=T1G5A6 T1G5A6 20216253 PTHR45816:SF4 MIR DOMAIN-CONTAINING PROTEIN RYR_IP3R HOMOLOGY ASSOCIATED DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186006|UniProtKB=T1FNJ5 T1FNJ5 20210392 PTHR43464:SF19 METHYLTRANSFERASE UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL methyltransferase activity#GO:0008168;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824 methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG179858|UniProtKB=T1FF78 T1FF78 20207477 PTHR22883:SF301 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC12 palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular localization#GO:0051641;macromolecule localization#GO:0033036;macromolecule modification#GO:0043412;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;protein palmitoylation#GO:0018345;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;localization within membrane#GO:0051668;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein localization to membrane#GO:0072657;organonitrogen compound biosynthetic process#GO:1901566;protein targeting#GO:0006605;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;protein acylation#GO:0043543;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipoprotein biosynthetic process#GO:0042158;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;lipoprotein metabolic process#GO:0042157 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG66792|UniProtKB=T1FYR0 T1FYR0 20213958 PTHR24418:SF294 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE BTK29A protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG195157|UniProtKB=T1FWT7 T1FWT7 20213282 PTHR20371:SF1 ENOLASE-PHOSPHATASE E1 ENOLASE-PHOSPHATASE E1 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;sulfur compound metabolic process#GO:0006790;proteinogenic amino acid biosynthetic process#GO:0170038;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;aspartate family amino acid biosynthetic process#GO:0009067;alpha-amino acid biosynthetic process#GO:1901607;nitrogen compound metabolic process#GO:0006807;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;aspartate family amino acid metabolic process#GO:0009066;small molecule biosynthetic process#GO:0044283;L-amino acid biosynthetic process#GO:0170034;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG191907|UniProtKB=T1FTE6 T1FTE6 20212093 PTHR23063:SF52 PHOSPHOLIPID ACYLTRANSFERASE LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASE acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG184982|UniProtKB=T1FM81 T1FM81 20209930 PTHR33539:SF1 UPF0764 PROTEIN C16ORF89 UPF0764 PROTEIN C16ORF89 HELRO|EnsemblGenome=HelroG182937|UniProtKB=T1FIY0 T1FIY0 20208779 PTHR23418:SF0 ACIREDUCTONE DIOXYGENASE ACIREDUCTONE DIOXYGENASE oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213 oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;sulfur compound metabolic process#GO:0006790;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;alpha-amino acid metabolic process#GO:1901605;aspartate family amino acid metabolic process#GO:0009066;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152 oxygenase#PC00177;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG64595|UniProtKB=T1FXW8 T1FXW8 20213666 PTHR12210:SF3 DULLARD PROTEIN PHOSPHATASE MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM50 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 cellular localization#GO:0051641;transmembrane transport#GO:0055085;macromolecule localization#GO:0033036;transport#GO:0006810;protein transmembrane transport#GO:0071806;protein targeting#GO:0006605;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;protein localization to mitochondrion#GO:0070585;cellular process#GO:0009987;protein transmembrane import into intracellular organelle#GO:0044743;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;mitochondrial transport#GO:0006839;organic substance transport#GO:0071702;protein import into mitochondrial matrix#GO:0030150;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein targeting to mitochondrion#GO:0006626;establishment of protein localization to mitochondrion#GO:0072655;protein transport#GO:0015031;protein localization to organelle#GO:0033365;mitochondrial transmembrane transport#GO:1990542 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;TIM23 mitochondrial import inner membrane translocase complex#GO:0005744;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;mitochondrial protein-containing complex#GO:0098798 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG179012|UniProtKB=T1FE20 T1FE20 20207069 PTHR31334:SF1 SMITH-MAGENIS SYNDROME REGION GENE 8 PROTEIN GUANINE NUCLEOTIDE EXCHANGE PROTEIN SMCR8 guanyl-nucleotide exchange factor complex#GO:0032045;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG156400|UniProtKB=T1ELV6 T1ELV6 20197556 PTHR10529:SF236 AP COMPLEX SUBUNIT MU AP-2 COMPLEX SUBUNIT MU localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;import into cell#GO:0098657;transport#GO:0006810;endocytosis#GO:0006897 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 CCKR signaling map#P06959>AP2M1#P07067 HELRO|EnsemblGenome=HelroG162278|UniProtKB=T1ESG0 T1ESG0 20199510 PTHR15081:SF1 NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED NUCLEAR AUTOANTIGENIC SPERM PROTEIN protein binding#GO:0005515;binding#GO:0005488;histone binding#GO:0042393 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;organelle organization#GO:0006996;chromosome organization#GO:0051276;protein-containing complex organization#GO:0043933;protein-containing complex assembly#GO:0065003;chromatin organization#GO:0006325;cellular component organization#GO:0016043;cellular process#GO:0009987;chromatin remodeling#GO:0006338;protein-DNA complex assembly#GO:0065004 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG174349|UniProtKB=T1F812 T1F812 20204961 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG64935|UniProtKB=T1FY15 T1FY15 20213713 PTHR12141:SF5 ARFAPTIN-RELATED ARFAPTIN lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488 cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;trans-Golgi network membrane#GO:0032588;organelle subcompartment#GO:0031984;Golgi apparatus subcompartment#GO:0098791;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG185550|UniProtKB=T1FMZ1 T1FMZ1 20210190 PTHR11711:SF30 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR 1 carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 G-protein#PC00020 Integrin signalling pathway#P00034>Arf1#P00923;Huntington disease#P00029>ARF#P00786 HELRO|EnsemblGenome=HelroG65821|UniProtKB=T1FYD0 T1FYD0 20213828 PTHR12737:SF9 DIMETHYLARGININE DIMETHYLAMINOHYDROLASE DIMETHYLARGININASE amino acid binding#GO:0016597;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;carboxylic acid binding#GO:0031406;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;anion binding#GO:0043168;ion binding#GO:0043167;organic acid binding#GO:0043177 positive regulation of nitrogen compound metabolic process#GO:0051173;oxoacid metabolic process#GO:0043436;regulation of nitrogen compound metabolic process#GO:0051171;arginine metabolic process#GO:0006525;positive regulation of cellular metabolic process#GO:0031325;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;alpha-amino acid metabolic process#GO:1901605;carboxylic acid metabolic process#GO:0019752;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;amino acid metabolic process#GO:0006520;regulation of cellular metabolic process#GO:0031323;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 hydrolase#PC00121 HELRO|EnsemblGenome=HelroG162466|UniProtKB=T1ESP8 T1ESP8 20199598 PTHR45638:SF11 CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A protein-containing complex binding#GO:0044877;binding#GO:0005488 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG89336|UniProtKB=T1G7C2 T1G7C2 20216969 PTHR11404:SF6 SUPEROXIDE DISMUTASE 2 SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG179784|UniProtKB=T1FF55 T1FF55 20207454 PTHR25462:SF291 BONUS, ISOFORM C-RELATED E3 UBIQUITIN-PROTEIN LIGASE TRIM45 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG176552|UniProtKB=T1FAN1 T1FAN1 20205880 PTHR46984:SF1 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 71 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 71 HELRO|EnsemblGenome=HelroG183179|UniProtKB=T1FJ95 T1FJ95 20208894 PTHR11905:SF159 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG99528|UniProtKB=T1G9T3 T1G9T3 20217829 PTHR46849:SF1 RCC1 DOMAIN-CONTAINING PROTEIN 1 RCC1 DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG66930|UniProtKB=T1FYT5 T1FYT5 20213983 PTHR10032:SF271 ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS RH12261P-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG127062|UniProtKB=T1EHC7 T1EHC7 20195977 PTHR19818:SF157 ZINC FINGER PROTEIN ZIC AND GLI C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG102867|UniProtKB=T1EDC6 T1EDC6 20194578 PTHR43294:SF21 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA CATION TRANSPORTING ATPASE primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG178980|UniProtKB=T1FE02 T1FE02 20207051 PTHR45692:SF1 G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174367|UniProtKB=T1F817 T1F817 20204966 PTHR19282:SF544 TETRASPANIN TETRASPANIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG116782|UniProtKB=T1EGH6 T1EGH6 20195678 PTHR18929:SF132 PROTEIN DISULFIDE ISOMERASE PROTEIN DISULFIDE-ISOMERASE A3 isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;protein disulfide isomerase activity#GO:0003756 cellular response to stimulus#GO:0051716;macromolecule biosynthetic process#GO:0009059;response to endoplasmic reticulum stress#GO:0034976;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;response to stress#GO:0006950;protein folding#GO:0006457;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG97639|UniProtKB=T1G9I2 T1G9I2 20217729 PTHR11915:SF442 SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN ALPHA-ACTININ, SARCOMERIC-RELATED cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;organelle organization#GO:0006996 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;cell cortex#GO:0005938;cell periphery#GO:0071944;cortical actin cytoskeleton#GO:0030864;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Integrin signalling pathway#P00034>alpha actinin#P00928 HELRO|EnsemblGenome=HelroG161035|UniProtKB=T1ER14 T1ER14 20199014 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG88439|UniProtKB=T1G726 T1G726 20216873 PTHR11054:SF0 6-PHOSPHOGLUCONOLACTONASE 6-PHOSPHOGLUCONOLACTONASE metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG87652|UniProtKB=T1G6T8 T1G6T8 20216785 PTHR43461:SF1 TRANSMEMBRANE PROTEIN 256 TRANSMEMBRANE PROTEIN 256 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG189301|UniProtKB=T1FQX8 T1FQX8 20211225 PTHR13230:SF5 GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5 GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5 cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;rDNA binding#GO:0000182 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;transcription factor TFIIIC complex#GO:0000127 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG170691|UniProtKB=T1F3B6 T1F3B6 20203315 PTHR23107:SF34 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN HTH LA-TYPE RNA-BINDING DOMAIN-CONTAINING PROTEIN transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG170175|UniProtKB=T1F2R0 T1F2R0 20203109 PTHR23157:SF25 GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1 GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG169259|UniProtKB=T1F1N2 T1F1N2 20202732 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161437|UniProtKB=T1ERH1 T1ERH1 20199171 PTHR33137:SF48 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15A-RELATED E3 UBIQUITIN-PROTEIN LIGASE IRF2BPL-RELATED general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG173311|UniProtKB=T1F6N7 T1F6N7 20204486 PTHR35261:SF3 ORGANELLAR PROTEIN, PUTATIVE-RELATED-RELATED VACUOLAR IMPORT AND DEGRADATION PROTEIN 22 HELRO|EnsemblGenome=HelroG69476|UniProtKB=T1FZV7 T1FZV7 20214355 PTHR33091:SF29 PROTEIN, PUTATIVE, EXPRESSED-RELATED SUBTILISIN INHIBITOR 1 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG190263|UniProtKB=T1FRU1 T1FRU1 20211538 PTHR13832:SF354 PROTEIN PHOSPHATASE 2C GM14138P hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;dephosphorylation#GO:0016311;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;protein metabolic process#GO:0019538;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG184927|UniProtKB=T1FM61 T1FM61 20209910 PTHR23105:SF38 RIBOSOMAL PROTEIN L7AE FAMILY MEMBER NHP2-LIKE PROTEIN 1 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG179201|UniProtKB=T1FEC6 T1FEC6 20207175 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG75620|UniProtKB=T1G275 T1G275 20215173 PTHR12121:SF37 CARBON CATABOLITE REPRESSOR PROTEIN 4 2',5'-PHOSPHODIESTERASE 12 catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787;3'-5'-RNA exonuclease activity#GO:0000175;3'-5' exonuclease activity#GO:0008408;exonuclease activity#GO:0004527;RNA nuclease activity#GO:0004540 negative regulation of gene expression#GO:0010629;regulation of catabolic process#GO:0009894;heterocycle catabolic process#GO:0046700;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;nucleobase-containing compound metabolic process#GO:0006139;RNA destabilization#GO:0050779;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;regulation of biological quality#GO:0065008;nitrogen compound metabolic process#GO:0006807;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;positive regulation of mRNA catabolic process#GO:0061014;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of catabolic process#GO:0009896;mRNA destabilization#GO:0061157;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323;positive regulation of nitrogen compound metabolic process#GO:0051173;cellular aromatic compound metabolic process#GO:0006725;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;RNA metabolic process#GO:0016070;positive regulation of cellular catabolic process#GO:0031331;cellular nitrogen compound catabolic process#GO:0044270;organic cyclic compound metabolic process#GO:1901360;positive regulation of metabolic process#GO:0009893;mRNA catabolic process#GO:0006402;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;positive regulation of mRNA metabolic process#GO:1903313;heterocycle metabolic process#GO:0046483;negative regulation of biosynthetic process#GO:0009890;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of cellular catabolic process#GO:0031329;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;positive regulation of RNA metabolic process#GO:0051254 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG156251|UniProtKB=T1ELT4 T1ELT4 20197534 PTHR48094:SF12 PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED PARKINSON DISEASE PROTEIN 7 HOMOLOG cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG93910|UniProtKB=T1G8Y1 T1G8Y1 20217528 PTHR12385:SF14 CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44) CHOLINE TRANSPORTER-LIKE 2 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG114622|UniProtKB=T1EG35 T1EG35 20195537 PTHR10602:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1 EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1 nucleic acid binding#GO:0003676;translation regulator activity#GO:0045182;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation initiation factor activity#GO:0003743;ribonucleoprotein complex binding#GO:0043021;ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877;translation regulator activity, nucleic acid binding#GO:0090079;translation factor activity, RNA binding#GO:0008135 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;translational initiation#GO:0006413;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 Apoptosis signaling pathway#P00006>ELF2alpha#P00307 HELRO|EnsemblGenome=HelroG119637|UniProtKB=T1EGN4 T1EGN4 20195734 PTHR22762:SF131 ALPHA-GLUCOSIDASE GLYCOSIDE HYDROLASE FAMILY 31 N-TERMINAL DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;glucosidase activity#GO:0015926;hydrolase activity, acting on glycosyl bonds#GO:0016798;alpha-glucosidase activity#GO:0090599;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 glucosidase#PC00108;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG181599|UniProtKB=T1FH55 T1FH55 20208154 PTHR46077:SF5 E3 UBIQUITIN-PROTEIN LIGASE TOPORS RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein monoubiquitination#GO:0006513;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG84693|UniProtKB=T1G5M2 T1G5M2 20216369 PTHR11932:SF168 CULLIN CULLIN-3 enzyme binding#GO:0019899;protein binding#GO:0005515;ubiquitin protein ligase binding#GO:0031625;binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185524|UniProtKB=T1FMX6 T1FMX6 20210175 PTHR45644:SF3 AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED FI08533P-RELATED envelope#GO:0031975;bounding membrane of organelle#GO:0098588;mitochondrial membrane#GO:0031966;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867 HELRO|EnsemblGenome=HelroG188591|UniProtKB=T1FQ55 T1FQ55 20210952 PTHR23004:SF11 DOUBLECORTIN DOMAIN CONTAINING 2 PROTEIN RPI-1 HELRO|EnsemblGenome=HelroG164063|UniProtKB=T1EUV0 T1EUV0 20200350 PTHR33395:SF21 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED PERICARDIN heart morphogenesis#GO:0003007;system development#GO:0048731;heart development#GO:0007507;circulatory system development#GO:0072359;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;animal organ development#GO:0048513;multicellular organism development#GO:0007275;developmental process#GO:0032502;animal organ morphogenesis#GO:0009887;multicellular organismal process#GO:0032501;cell adhesion#GO:0007155;cellular process#GO:0009987;post-embryonic development#GO:0009791 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG186308|UniProtKB=T1FNY1 T1FNY1 20210528 PTHR10830:SF0 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;protein metabolic process#GO:0019538;protein N-linked glycosylation via asparagine#GO:0018279;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 membrane protein complex#GO:0098796;endoplasmic reticulum protein-containing complex#GO:0140534;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;oligosaccharyltransferase complex#GO:0008250;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG70306|UniProtKB=T1G043 T1G043 20214441 PTHR12166:SF8 CALCIUM-DEPENDENT SECRETION ACTIVATOR CALCIUM-DEPENDENT SECRETION ACTIVATOR localization#GO:0051179;establishment of localization#GO:0051234;exocytosis#GO:0006887;secretion#GO:0046903;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;export from cell#GO:0140352;secretion by cell#GO:0032940 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG189581|UniProtKB=T1FR62 T1FR62 20211309 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG166314|UniProtKB=T1EY06 T1EY06 20201456 PTHR13832:SF803 PROTEIN PHOSPHATASE 2C PROTEIN PHOSPHATASE 1G macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;dephosphorylation#GO:0016311;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG62861|UniProtKB=T1FX63 T1FX63 20213411 PTHR45755:SF4 FAMILY NOT NAMED ZINC TRANSPORTER 7 inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873 localization#GO:0051179;monoatomic cation transport#GO:0006812;metal ion transport#GO:0030001;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810 HELRO|EnsemblGenome=HelroG167618|UniProtKB=T1EZK6 T1EZK6 20202006 PTHR24238:SF75 G-PROTEIN COUPLED RECEPTOR CHOLECYSTOKININ-LIKE RECEPTOR AT 17D1-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;neuropeptide signaling pathway#GO:0007218;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG71308|UniProtKB=T1G0J4 T1G0J4 20214592 PTHR10497:SF0 60S RIBOSOMAL PROTEIN L27 LARGE RIBOSOMAL SUBUNIT PROTEIN EL27 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG112157|UniProtKB=T1EFH3 T1EFH3 20195325 PTHR43740:SF2 LEUCYL-TRNA SYNTHETASE LEUCINE--TRNA LIGASE, MITOCHONDRIAL catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG164475|UniProtKB=T1EVH0 T1EVH0 20200570 PTHR14130:SF14 3BP-1 RELATED RHOGAP RHO GTPASE-ACTIVATING PROTEIN 92B nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of cytoskeleton organization#GO:0051493;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;regulation of organelle organization#GO:0033043;regulation of signaling#GO:0023051;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of cellular component organization#GO:0051128;regulation of actin filament-based process#GO:0032970;regulation of intracellular signal transduction#GO:1902531;regulation of small GTPase mediated signal transduction#GO:0051056 cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 G-protein modulator#PC00022;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG92191|UniProtKB=T1G8C8 T1G8C8 20217325 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG166123|UniProtKB=T1EXT5 T1EXT5 20201385 PTHR10264:SF19 BAND 7 PROTEIN-RELATED AT06885P-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG185199|UniProtKB=T1FMI0 T1FMI0 20210029 PTHR22846:SF2 WD40 REPEAT PROTEIN F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;protein-macromolecule adaptor activity#GO:0030674 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;histone deacetylase complex#GO:0000118;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 Wnt signaling pathway#P00057>Ebi#P01453 HELRO|EnsemblGenome=HelroG191330|UniProtKB=T1FSW3 T1FSW3 20211910 PTHR34740:SF5 FINGER, C3HC4 TYPE, PUTATIVE-RELATED-RELATED POLYMERASE NUCLEOTIDYL TRANSFERASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG66455|UniProtKB=T1FYL3 T1FYL3 20213911 PTHR21680:SF0 COILED-COIL DOMAIN-CONTAINING PROTEIN 124 COILED-COIL DOMAIN-CONTAINING PROTEIN 124 transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG64799|UniProtKB=T1FXZ5 T1FXZ5 20213693 PTHR13071:SF4 MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S22 SMALL RIBOSOMAL SUBUNIT PROTEIN MS22 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;organellar ribosome#GO:0000313;protein-containing complex#GO:0032991;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;small ribosomal subunit#GO:0015935;ribosome#GO:0005840;mitochondrial small ribosomal subunit#GO:0005763;mitochondrial protein-containing complex#GO:0098798 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG189384|UniProtKB=T1FR05 T1FR05 20211252 PTHR46582:SF1 ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 18 ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 18 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;precatalytic spliceosome#GO:0071011;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG163511|UniProtKB=T1EU57 T1EU57 20200107 PTHR45828:SF42 CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE DEFENSE PROTEIN L(2)34FC cellular anatomical entity#GO:0110165;membrane#GO:0016020 reductase#PC00198;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG154551|UniProtKB=T1ELF1 T1ELF1 20197401 PTHR47979:SF33 DRAB11-RELATED DRAB11 GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;anion binding#GO:0043168;ion binding#GO:0043167 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;transport#GO:0006810 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG174686|UniProtKB=T1F8D4 T1F8D4 20205083 PTHR16515:SF66 PR DOMAIN ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG184462|UniProtKB=T1FL91 T1FL91 20209590 PTHR16089:SF40 REST COREPRESSOR COREST PROTEIN-RELATED SUPPRESSOR OF ACTIVATED EGL-4 PROTEIN 1 molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;protein-macromolecule adaptor activity#GO:0030674 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;histone deacetylase complex#GO:0000118;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG86660|UniProtKB=T1G6F1 T1G6F1 20216648 PTHR23086:SF101 PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE LP03320P-RELATED transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301;lipid kinase activity#GO:0001727 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 kinase#PC00137 HELRO|EnsemblGenome=HelroG175867|UniProtKB=T1F9S8 T1F9S8 20205577 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG79989|UniProtKB=T1G3W0 T1G3W0 20215758 PTHR18945:SF865 NEUROTRANSMITTER GATED ION CHANNEL NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA7, ISOFORM E ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG86708|UniProtKB=T1G6F9 T1G6F9 20216656 PTHR24033:SF224 EGF-LIKE DOMAIN-CONTAINING PROTEIN C-TYPE LECTIN HELRO|EnsemblGenome=HelroG70092|UniProtKB=T1G028 T1G028 20214426 PTHR24418:SF421 TYROSINE-PROTEIN KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG93914|UniProtKB=T1G8Y2 T1G8Y2 20217529 PTHR32343:SF22 SERINE/ARGININE-RICH SPLICING FACTOR LD29830P RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG176894|UniProtKB=T1FB11 T1FB11 20206010 PTHR24026:SF136 FAT ATYPICAL CADHERIN-RELATED PROTOCADHERIN-23 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG186210|UniProtKB=T1FNT7 T1FNT7 20210484 PTHR11669:SF5 REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT REPLICATION FACTOR C SUBUNIT 2 ATP-dependent activity, acting on DNA#GO:0008094;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on DNA#GO:0140097;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;response to stress#GO:0006950;nitrogen compound metabolic process#GO:0006807;DNA-templated DNA replication#GO:0006261;DNA replication#GO:0006260;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;replication fork#GO:0005657 DNA-directed DNA polymerase#PC00018 DNA replication#P00017>RFC#P00529 HELRO|EnsemblGenome=HelroG171194|UniProtKB=T1F3X3 T1F3X3 20203522 PTHR44755:SF8 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide hormone binding#GO:0017046;hormone binding#GO:0042562;binding#GO:0005488;peptide binding#GO:0042277;amide binding#GO:0033218 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG87454|UniProtKB=T1G6Q3 T1G6Q3 20216750 PTHR23122:SF7 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK PERIPHERAL PLASMA MEMBRANE PROTEIN CASK protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 regulation of cell communication#GO:0010646;cellular localization#GO:0051641;macromolecule localization#GO:0033036;regulation of signaling#GO:0023051;regulation of localization#GO:0032879;regulation of secretion by cell#GO:1903530;cellular process#GO:0009987;regulation of neurotransmitter secretion#GO:0046928;protein localization#GO:0008104;regulation of biological process#GO:0050789;localization#GO:0051179;regulation of transport#GO:0051049;cellular macromolecule localization#GO:0070727;regulation of cellular process#GO:0050794;regulation of secretion#GO:0051046;modulation of chemical synaptic transmission#GO:0050804;biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177 cell junction#GO:0030054;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911;anchoring junction#GO:0070161;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 Parkinson disease#P00049>CASK#P01232;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CaMK#P00847 HELRO|EnsemblGenome=HelroG185708|UniProtKB=T1FN64 T1FN64 20210262 PTHR23064:SF71 TROPONIN EF-HAND DOMAIN-CONTAINING PROTEIN cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG163113|UniProtKB=T1ETN9 T1ETN9 20199939 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG176841|UniProtKB=T1FAY4 T1FAY4 20205983 PTHR10545:SF29 DIAMINE N-ACETYLTRANSFERASE GH14572P-RELATED acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;catalytic activity#GO:0003824;N-acyltransferase activity#GO:0016410 acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG192952|UniProtKB=T1FUG4 T1FUG4 20212460 PTHR12480:SF32 ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD BIFUNCTIONAL ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD6 histone modifying activity#GO:0140993;demethylase activity#GO:0032451;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;histone demethylase activity#GO:0032452;binding#GO:0005488;catalytic activity#GO:0003824;dioxygenase activity#GO:0051213;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;protein-containing complex binding#GO:0044877;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG182160|UniProtKB=T1FHU6 T1FHU6 20208395 PTHR23189:SF45 RNA RECOGNITION MOTIF-CONTAINING RNA-BINDING PROTEIN SPENITO RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG77491|UniProtKB=T1G2Y5 T1G2Y5 20215433 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG159637|UniProtKB=T1EP98 T1EP98 20198398 PTHR47577:SF2 THAP DOMAIN-CONTAINING PROTEIN 6 THAP DOMAIN CONTAINING 9 HELRO|EnsemblGenome=HelroG193832|UniProtKB=T1FVE5 T1FVE5 20212791 PTHR19860:SF42 DDB1- AND CUL4-ASSOCIATED FACTOR 12-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234;Cul4-RING E3 ubiquitin ligase complex#GO:0080008 HELRO|EnsemblGenome=HelroG145664|UniProtKB=T1EJL9 T1EJL9 20196769 PTHR24193:SF121 ANKYRIN REPEAT PROTEIN ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D HELRO|EnsemblGenome=HelroG62433|UniProtKB=T1FX06 T1FX06 20213354 PTHR45618:SF12 MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED MITOCHONDRIAL UNCOUPLING PROTEIN 1 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;mitochondrial transport#GO:0006839;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;mitochondrial transmembrane transport#GO:1990542;transport#GO:0006810 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG167351|UniProtKB=T1EZA6 T1EZA6 20201906 PTHR45713:SF15 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG81531|UniProtKB=T1G4F4 T1G4F4 20215952 PTHR10797:SF0 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT POLY(A)-SPECIFIC RIBONUCLEASE catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787;3'-5'-RNA exonuclease activity#GO:0000175;3'-5' exonuclease activity#GO:0008408;exonuclease activity#GO:0004527;RNA nuclease activity#GO:0004540 negative regulation of gene expression#GO:0010629;regulation of catabolic process#GO:0009894;heterocycle catabolic process#GO:0046700;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;nucleobase-containing compound metabolic process#GO:0006139;RNA destabilization#GO:0050779;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;regulation of biological quality#GO:0065008;nitrogen compound metabolic process#GO:0006807;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;positive regulation of mRNA catabolic process#GO:0061014;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of catabolic process#GO:0009896;mRNA destabilization#GO:0061157;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323;positive regulation of nitrogen compound metabolic process#GO:0051173;cellular aromatic compound metabolic process#GO:0006725;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;RNA metabolic process#GO:0016070;positive regulation of cellular catabolic process#GO:0031331;cellular nitrogen compound catabolic process#GO:0044270;organic cyclic compound metabolic process#GO:1901360;positive regulation of metabolic process#GO:0009893;mRNA catabolic process#GO:0006402;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;positive regulation of mRNA metabolic process#GO:1903313;heterocycle metabolic process#GO:0046483;negative regulation of biosynthetic process#GO:0009890;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of cellular catabolic process#GO:0031329;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;positive regulation of RNA metabolic process#GO:0051254 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;protein-containing complex#GO:0032991;P-body#GO:0000932;CCR4-NOT complex#GO:0030014;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG190729|UniProtKB=T1FS89 T1FS89 20211686 PTHR22588:SF3 VWFA DOMAIN-CONTAINING PROTEIN VWFA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168982|UniProtKB=T1F179 T1F179 20202579 PTHR15907:SF182 DUF614 FAMILY PROTEIN-RELATED PROTEIN PLANT CADMIUM RESISTANCE 1-RELATED HELRO|EnsemblGenome=HelroG77414|UniProtKB=T1G2X2 T1G2X2 20215420 PTHR15698:SF10 PROTEIN CBG15099 PHYTANOYL-COA HYDROXYLASE-INTERACTING PROTEIN-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191850|UniProtKB=T1FTC6 T1FTC6 20212073 PTHR23407:SF6 ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE ATPASE INHIBITOR, MITOCHONDRIAL ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;folic acid-containing compound metabolic process#GO:0006760;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;cellular modified amino acid metabolic process#GO:0006575;aromatic compound biosynthetic process#GO:0019438;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG112879|UniProtKB=T1EFM8 T1EFM8 20195380 PTHR10856:SF0 CORONIN CORONIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG82245|UniProtKB=T1G4P6 T1G4P6 20216044 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG189601|UniProtKB=T1FR69 T1FR69 20211316 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG173483|UniProtKB=T1F6V5 T1F6V5 20204554 PTHR21035:SF2 28S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL SMALL RIBOSOMAL SUBUNIT PROTEIN MS26 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;organellar ribosome#GO:0000313;protein-containing complex#GO:0032991;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;small ribosomal subunit#GO:0015935;ribosome#GO:0005840;mitochondrial small ribosomal subunit#GO:0005763;mitochondrial protein-containing complex#GO:0098798 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG185410|UniProtKB=T1FMS1 T1FMS1 20210120 PTHR24320:SF282 RETINOL DEHYDROGENASE WW DOMAIN-CONTAINING OXIDOREDUCTASE dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG76318|UniProtKB=T1G2I3 T1G2I3 20215281 PTHR10390:SF61 HOMEOBOX PROTEIN SIX HOMEOBOX PROTEIN SIX2 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG88259|UniProtKB=T1G709 T1G709 20216856 PTHR23235:SF48 KRUEPPEL-LIKE TRANSCRIPTION FACTOR KRUEPPEL-LIKE FACTOR 3 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG162197|UniProtKB=T1ESC4 T1ESC4 20199474 PTHR12825:SF0 BNIP1-RELATED VESICLE TRANSPORT PROTEIN SEC20 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;Golgi vesicle transport#GO:0048193;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;transport#GO:0006810 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;SNARE complex#GO:0031201;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG193031|UniProtKB=T1FUJ6 T1FUJ6 20212492 PTHR15881:SF2 MARGINAL ZONE B- AND B1-CELL-SPECIFIC PROTEIN MARGINAL ZONE B- AND B1-CELL-SPECIFIC PROTEIN regulation of biological process#GO:0050789;regulation of cell activation#GO:0050865;regulation of leukocyte activation#GO:0002694;regulation of multicellular organismal process#GO:0051239;regulation of mononuclear cell proliferation#GO:0032944;regulation of cell population proliferation#GO:0042127;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of lymphocyte proliferation#GO:0050670;regulation of immune system process#GO:0002682;regulation of leukocyte proliferation#GO:0070663;regulation of lymphocyte activation#GO:0051249;regulation of B cell proliferation#GO:0030888 cytoplasm#GO:0005737;endoplasmic reticulum protein-containing complex#GO:0140534;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG190261|UniProtKB=T1FRU0 T1FRU0 20211537 PTHR19282:SF562 TETRASPANIN AT12771P-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG82280|UniProtKB=T1G4Q2 T1G4Q2 20216050 PTHR23073:SF155 26S PROTEASOME REGULATORY SUBUNIT 26S PROTEASOME REGULATORY SUBUNIT 6B ATP-dependent activity#GO:0140657 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 peptidase complex#GO:1905368;protein-containing complex#GO:0032991;proteasome accessory complex#GO:0022624;proteasome regulatory particle#GO:0005838;catalytic complex#GO:1902494;proteasome complex#GO:0000502;endopeptidase complex#GO:1905369;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 protease#PC00190;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489;Ubiquitin proteasome pathway#P00060>19S proteasome#P01494 HELRO|EnsemblGenome=HelroG115955|UniProtKB=T1EGC0 T1EGC0 20195622 PTHR23413:SF1 60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N RIBOSOMAL PROTEIN L32 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG192823|UniProtKB=T1FUC1 T1FUC1 20212417 PTHR16121:SF0 CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1-RELATED CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1 catalytic activity, acting on RNA#GO:0140098;transferase activity#GO:0016740;O-methyltransferase activity#GO:0008171;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;RNA methyltransferase activity#GO:0008173 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;mRNA modification#GO:0016556;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;macromolecule methylation#GO:0043414;methylation#GO:0032259;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mRNA processing#GO:0006397;RNA methylation#GO:0001510;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG181703|UniProtKB=T1FH88 T1FH88 20208187 PTHR20963:SF8 MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE 1 hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG171204|UniProtKB=T1F3X7 T1F3X7 20203526 PTHR44755:SF8 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide hormone binding#GO:0017046;hormone binding#GO:0042562;binding#GO:0005488;peptide binding#GO:0042277;amide binding#GO:0033218 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG185838|UniProtKB=T1FNC8 T1FNC8 20210325 PTHR31400:SF1 GUANYLYL CYCLASE DOMAIN CONTAINING PROTEIN 1 GUCD1 PROTEIN GUCD1 cyclase#PC00079;guanylate cyclase#PC00114;lyase#PC00144 HELRO|EnsemblGenome=HelroG165489|UniProtKB=T1EWW5 T1EWW5 20201065 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG89869|UniProtKB=T1G7I5 T1G7I5 20217032 PTHR21431:SF0 PREFOLDIN SUBUNIT 6 PREFOLDIN SUBUNIT 6 protein binding#GO:0005515;protein-folding chaperone binding#GO:0051087;binding#GO:0005488 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein-containing complex assembly#GO:0065003;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;chaperone-mediated protein complex assembly#GO:0051131;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nitrogen compound metabolic process#GO:0006807;protein-containing complex organization#GO:0043933;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185468|UniProtKB=T1FMU9 T1FMU9 20210148 PTHR18945:SF914 NEUROTRANSMITTER GATED ION CHANNEL NEUROTRANSMITTER-GATED ION-CHANNEL LIGAND-BINDING DOMAIN-CONTAINING PROTEIN transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission#GO:0007268;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 cell junction#GO:0030054;synapse#GO:0045202;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;neuron projection#GO:0043005 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG64140|UniProtKB=T1FXQ1 T1FXQ1 20213599 PTHR45617:SF166 LEUCINE RICH REPEAT FAMILY PROTEIN PODOCAN-LIKE PROTEIN 1 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG189289|UniProtKB=T1FQX3 T1FQX3 20211220 PTHR13469:SF8 HEXAMETHYLENE BISACETAMIDE INDUCIBLE 1 HEXIM P-TEFB COMPLEX SUBUNIT 1 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;binding#GO:0005488;organic cyclic compound binding#GO:0097159;enzyme inhibitor activity#GO:0004857;snRNA binding#GO:0017069;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;protein kinase inhibitor activity#GO:0004860;kinase regulator activity#GO:0019207 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;negative regulation of RNA metabolic process#GO:0051253;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of catalytic activity#GO:0050790;negative regulation of protein phosphorylation#GO:0001933;regulation of phosphorus metabolic process#GO:0051174;regulation of biological process#GO:0050789;negative regulation of protein modification process#GO:0031400;regulation of biosynthetic process#GO:0009889;regulation of molecular function#GO:0065009;regulation of protein serine/threonine kinase activity#GO:0071900;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of protein kinase activity#GO:0006469;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of cellular process#GO:0048523;regulation of cyclin-dependent protein serine/threonine kinase activity#GO:0000079;regulation of kinase activity#GO:0043549;regulation of protein kinase activity#GO:0045859;negative regulation of biosynthetic process#GO:0009890;regulation of DNA-templated transcription#GO:0006355;negative regulation of cell cycle#GO:0045786;negative regulation of phosphorus metabolic process#GO:0010563;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of protein phosphorylation#GO:0001932;negative regulation of phosphorylation#GO:0042326;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of phosphate metabolic process#GO:0045936;regulation of cell cycle#GO:0051726;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of transferase activity#GO:0051338;negative regulation of catalytic activity#GO:0043086;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323;negative regulation of molecular function#GO:0044092 membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG102916|UniProtKB=T1EDD1 T1EDD1 20194583 PTHR15288:SF0 DENN DOMAIN-CONTAINING PROTEIN 2 UDENN DOMAIN-CONTAINING PROTEIN guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG72797|UniProtKB=T1G158 T1G158 20214806 PTHR19308:SF14 PHOSPHATIDYLCHOLINE TRANSFER PROTEIN START DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162498|UniProtKB=T1ESR2 T1ESR2 20199612 PTHR46532:SF4 MALE FERTILITY FACTOR KL5 AAA+ ATPASE DOMAIN-CONTAINING PROTEIN axoneme#GO:0005930;catalytic complex#GO:1902494;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;axonemal dynein complex#GO:0005858;microtubule associated complex#GO:0005875;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;plasma membrane bounded cell projection cytoplasm#GO:0032838;ciliary plasm#GO:0097014;dynein complex#GO:0030286;cell projection#GO:0042995;cytoskeleton#GO:0005856;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG183756|UniProtKB=T1FK56 T1FK56 20209205 PTHR46164:SF3 ATF6, ISOFORM C ATF6, ISOFORM C sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 signal transduction#GO:0007165;endoplasmic reticulum unfolded protein response#GO:0030968;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;response to unfolded protein#GO:0006986;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;signaling#GO:0023052;response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;cellular response to chemical stimulus#GO:0070887;cellular response to organic substance#GO:0071310;regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to topologically incorrect protein#GO:0035967;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;response to stress#GO:0006950;regulation of cellular biosynthetic process#GO:0031326;response to chemical#GO:0042221;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;response to topologically incorrect protein#GO:0035966;cellular response to unfolded protein#GO:0034620;biological regulation#GO:0065007;cellular response to stress#GO:0033554;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 Transcription regulation by bZIP transcription factor#P00055>CREB#P01383 HELRO|EnsemblGenome=HelroG176347|UniProtKB=T1FAE8 T1FAE8 20205797 PTHR13556:SF2 TRANSCRIPTIONAL ADAPTER 3-RELATED TRANSCRIPTIONAL ADAPTER 3 transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 SAGA-type complex#GO:0070461;peptidase complex#GO:1905368;histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;chromosome#GO:0005694;SAGA complex#GO:0000124 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG174497|UniProtKB=T1F870 T1F870 20205019 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175810|UniProtKB=T1F9P6 T1F9P6 20205545 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163905|UniProtKB=T1EUL6 T1EUL6 20200266 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168385|UniProtKB=T1F0I7 T1F0I7 20202337 PTHR24412:SF35 KELCH PROTEIN ACTIN-BINDING PROTEIN IPP scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG83371|UniProtKB=T1G548 T1G548 20216196 PTHR11599:SF15 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT ALPHA TYPE-7-1-RELATED macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protease#PC00190;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489;Parkinson disease#P00049>20S proteasome#P01227 HELRO|EnsemblGenome=HelroG158375|UniProtKB=T1EMQ3 T1EMQ3 20197853 PTHR19325:SF575 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING LOCOMOTION-RELATED PROTEIN HIKARU GENKI complement component#PC00078 HELRO|EnsemblGenome=HelroG156075|UniProtKB=T1ELR5 T1ELR5 20197515 PTHR10142:SF0 DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS damaged DNA binding#GO:0003684;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;interstrand cross-link repair#GO:0036297;nitrogen compound metabolic process#GO:0006807;response to radiation#GO:0009314;response to abiotic stimulus#GO:0009628;cellular response to light stimulus#GO:0071482;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;nucleotide-excision repair#GO:0006289;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;response to light stimulus#GO:0009416;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;base-excision repair#GO:0006284;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;response to UV#GO:0009411;chromosome organization#GO:0051276;organelle organization#GO:0006996;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleotide-excision repair complex#GO:0000109;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 damaged DNA-binding protein#PC00086;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG186288|UniProtKB=T1FNX4 T1FNX4 20210521 PTHR24089:SF736 SOLUTE CARRIER FAMILY 25 MITOCHONDRIAL COENZYME A TRANSPORTER SLC25A42 mitochondrial carrier protein#PC00158;secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG185255|UniProtKB=T1FMK3 T1FMK3 20210052 PTHR23281:SF18 MERLIN/MOESIN/EZRIN/RADIXIN MOESIN_EZRIN_RADIXIN HOMOLOG 1 cell adhesion molecule binding#GO:0050839;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;actin binding#GO:0003779;binding#GO:0005488 regulation of anatomical structure morphogenesis#GO:0022603;regulation of organelle organization#GO:0033043;positive regulation of transport#GO:0051050;regulation of localization#GO:0032879;regulation of cellular component organization#GO:0051128;regulation of cellular localization#GO:0060341;regulation of vesicle-mediated transport#GO:0060627;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of cell shape#GO:0008360;regulation of transport#GO:0051049;regulation of biological quality#GO:0065008;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;regulation of organelle assembly#GO:1902115;biological regulation#GO:0065007;positive regulation of protein localization#GO:1903829;positive regulation of biological process#GO:0048518;regulation of protein localization#GO:0032880 actin-based cell projection#GO:0098858;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;filopodium#GO:0030175 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG79987|UniProtKB=T1G3V9 T1G3V9 20215757 PTHR24637:SF416 COLLAGEN NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179567|UniProtKB=T1FEV8 T1FEV8 20207357 PTHR23176:SF129 RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 PDGF signaling pathway#P00047>Rho#P01174 HELRO|EnsemblGenome=HelroG130955|UniProtKB=T1EHU8 T1EHU8 20196148 PTHR45709:SF2 LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED LARGE SUBUNIT GTPASE 1 HOMOLOG hydrolase activity#GO:0016787;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG182719|UniProtKB=T1FIN0 T1FIN0 20208679 PTHR13454:SF11 PROTEIN MCM10 HOMOLOG PROTEIN MCM10 HOMOLOG sequence-specific double-stranded DNA binding#GO:1990837;DNA replication origin binding#GO:0003688;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;single-stranded DNA binding#GO:0003697;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;DNA-templated DNA replication#GO:0006261;DNA replication#GO:0006260;DNA replication initiation#GO:0006270;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;chromosome#GO:0005694;nuclear replication fork#GO:0043596;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;replication fork#GO:0005657 HELRO|EnsemblGenome=HelroG99392|UniProtKB=T1G9S5 T1G9S5 20217821 PTHR12097:SF0 SPLICING FACTOR 3B, SUBUNIT 1-RELATED SPLICING FACTOR 3B SUBUNIT 1 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375;spliceosomal complex assembly#GO:0000245 catalytic step 2 spliceosome#GO:0071013;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;U2-type spliceosomal complex#GO:0005684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;U2 snRNP#GO:0005686;U2-type prespliceosome#GO:0071004;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;U12-type spliceosomal complex#GO:0005689 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG177756|UniProtKB=T1FC73 T1FC73 20206422 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG152003|UniProtKB=T1EKN5 T1EKN5 20197135 PTHR23055:SF167 CALCIUM BINDING PROTEINS EF-HAND DOMAIN-CONTAINING PROTEIN cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG188082|UniProtKB=T1FPL8 T1FPL8 20210765 PTHR18934:SF91 ATP-DEPENDENT RNA HELICASE PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640 cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG94059|UniProtKB=T1G8Y7 T1G8Y7 20217534 PTHR32546:SF26 G-PROTEIN COUPLED RECEPTOR 158-RELATED SMOG, ISOFORM D G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG162893|UniProtKB=T1ETB9 T1ETB9 20199819 PTHR46114:SF2 APPLE DOMAIN-CONTAINING PROTEIN CULLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG65855|UniProtKB=T1FYD7 T1FYD7 20213835 PTHR11453:SF127 ANION EXCHANGE PROTEIN SOLUTE CARRIER FAMILY 4 MEMBER 11 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;homeostatic process#GO:0042592;cellular process#GO:0009987;chemical homeostasis#GO:0048878;monoatomic ion homeostasis#GO:0050801 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG192035|UniProtKB=T1FTJ0 T1FTJ0 20212137 PTHR47020:SF1 HILLARIN HILLARIN HELRO|EnsemblGenome=HelroG84266|UniProtKB=T1G5G7 T1G5G7 20216314 PTHR14663:SF2 METHYLTRANSFERASE NSUN7-RELATED METHYLTRANSFERASE NSUN7-RELATED HELRO|EnsemblGenome=HelroG182054|UniProtKB=T1FHN8 T1FHN8 20208337 PTHR19282:SF456 TETRASPANIN CD63 MOLECULE cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG159686|UniProtKB=T1EPB0 T1EPB0 20198410 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189295|UniProtKB=T1FQX5 T1FQX5 20211222 PTHR33936:SF25 PROTEIN CBG17840 C2H2-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG113751|UniProtKB=T1EFV9 T1EFV9 20195461 PTHR45674:SF9 DNA LIGASE 1/3 FAMILY MEMBER DNA LIGASE 3 catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity, acting on DNA#GO:0140097;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;DNA-templated DNA replication#GO:0006261;DNA replication#GO:0006260;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA strand elongation involved in DNA replication#GO:0006271 DNA ligase#PC00012 HELRO|EnsemblGenome=HelroG170165|UniProtKB=T1F2Q6 T1F2Q6 20203105 PTHR35270:SF2 FUSELESS, ISOFORM A FUSELESS, ISOFORM A HELRO|EnsemblGenome=HelroG177632|UniProtKB=T1FBZ0 T1FBZ0 20206339 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG77714|UniProtKB=T1G329 T1G329 20215477 PTHR10340:SF34 SPHINGOMYELIN PHOSPHODIESTERASE SPHINGOMYELIN PHOSPHODIESTERASE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric diester hydrolase activity#GO:0008081;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 phosphodiesterase#PC00185;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG177711|UniProtKB=T1FC43 T1FC43 20206392 PTHR11733:SF133 ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED PHOSPHATE-REGULATING NEUTRAL ENDOPEPTIDASE PHEX hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Endothelin signaling pathway#P00019>ECE1-3#P00585 HELRO|EnsemblGenome=HelroG87531|UniProtKB=T1G6R6 T1G6R6 20216763 PTHR12375:SF47 RNA-BINDING PROTEIN LUC7-RELATED LUC7-LIKE PROTEIN 3 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;mRNA splice site recognition#GO:0006376;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375;spliceosomal complex assembly#GO:0000245 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;U1 snRNP#GO:0005685;U2-type spliceosomal complex#GO:0005684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;U2-type prespliceosome#GO:0071004;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG191068|UniProtKB=T1FSK1 T1FSK1 20211798 PTHR17357:SF0 GM2 GANGLIOSIDE ACTIVATOR PROTEIN GANGLIOSIDE GM2 ACTIVATOR transporter activity#GO:0005215;lipid transporter activity#GO:0005319 lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;macromolecule localization#GO:0033036;carbohydrate derivative catabolic process#GO:1901136;transport#GO:0006810;glycolipid metabolic process#GO:0006664;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;lipid catabolic process#GO:0016042;cellular process#GO:0009987;liposaccharide metabolic process#GO:1903509;lipid transport#GO:0006869;sphingolipid metabolic process#GO:0006665;primary metabolic process#GO:0044238;ceramide metabolic process#GO:0006672;localization#GO:0051179;organic substance transport#GO:0071702;membrane lipid metabolic process#GO:0006643;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;lipid localization#GO:0010876;organic substance catabolic process#GO:1901575;sphingolipid catabolic process#GO:0030149;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;side of membrane#GO:0098552;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane#GO:0005886 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG161372|UniProtKB=T1ERE7 T1ERE7 20199147 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG87691|UniProtKB=T1G6U4 T1G6U4 20216791 PTHR11537:SF254 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG107093|UniProtKB=T1EE74 T1EE74 20194876 PTHR24006:SF733 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE RE52890P cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG161175|UniProtKB=T1ER69 T1ER69 20199069 PTHR11388:SF142 ORGANIC ANION TRANSPORTER SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 5A1 secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;organic substance transport#GO:0071702;establishment of localization#GO:0051234;organic anion transport#GO:0015711;transport#GO:0006810 basal plasma membrane#GO:0009925;basolateral plasma membrane#GO:0016323;plasma membrane region#GO:0098590;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;basal part of cell#GO:0045178;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG169959|UniProtKB=T1F2H2 T1F2H2 20203022 PTHR19282:SF431 TETRASPANIN TETRASPANIN 26A, ISOFORM B-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG177038|UniProtKB=T1FB60 T1FB60 20206059 PTHR48162:SF4 YALI0A06930P G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194783|UniProtKB=T1FWE7 T1FWE7 20213142 PTHR13170:SF16 O-GLCNACASE PROTEIN O-GLCNACASE metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG188490|UniProtKB=T1FQ18 T1FQ18 20210915 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG109965|UniProtKB=T1EEX7 T1EEX7 20195129 PTHR10037:SF288 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM SODIUM CHANNEL PROTEIN PARA monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;sodium channel activity#GO:0005272;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;inorganic cation transmembrane transporter activity#GO:0022890 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;membrane depolarization#GO:0051899;transport#GO:0006810;regulation of membrane potential#GO:0042391;system process#GO:0003008;action potential#GO:0001508;nervous system process#GO:0050877;cell communication#GO:0007154;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;sodium ion transport#GO:0006814;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;multicellular organismal process#GO:0032501;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 membrane protein complex#GO:0098796;sodium channel complex#GO:0034706;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG64985|UniProtKB=T1FY22 T1FY22 20213720 PTHR16301:SF25 IMPACT-RELATED PROTEIN IMPACT cellular response to stimulus#GO:0051716;regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;cellular process#GO:0009987;regulation of translational initiation#GO:0006446;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular biosynthetic process#GO:0031326;response to stress#GO:0006950;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;cellular response to stress#GO:0033554;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG158732|UniProtKB=T1EN61 T1EN61 20198011 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172856|UniProtKB=T1F608 T1F608 20204257 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183940|UniProtKB=T1FKB8 T1FKB8 20209267 PTHR15681:SF1 MAD2L1-BINDING PROTEIN MAD2L1-BINDING PROTEIN membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG85388|UniProtKB=T1G5W3 T1G5W3 20216460 PTHR11373:SF4 DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 cellular aromatic compound metabolic process#GO:0006725;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative metabolic process#GO:1901135;heterocycle catabolic process#GO:0046700;organonitrogen compound catabolic process#GO:1901565;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;purine-containing compound catabolic process#GO:0072523;phosphate-containing compound metabolic process#GO:0006796;cellular nitrogen compound catabolic process#GO:0044270;organic cyclic compound metabolic process#GO:1901360;purine nucleotide catabolic process#GO:0006195;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;purine nucleotide metabolic process#GO:0006163;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;nucleoside phosphate catabolic process#GO:1901292;carbohydrate derivative catabolic process#GO:1901136;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;nucleotide catabolic process#GO:0009166;nucleoside triphosphate catabolic process#GO:0009143;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organophosphate catabolic process#GO:0046434;primary metabolic process#GO:0044238;aromatic compound catabolic process#GO:0019439;organic cyclic compound catabolic process#GO:1901361;organophosphate metabolic process#GO:0019637;purine nucleoside triphosphate metabolic process#GO:0009144;nucleobase-containing compound catabolic process#GO:0034655;nucleotide metabolic process#GO:0009117;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG74448|UniProtKB=T1G1R3 T1G1R3 20215011 PTHR24418:SF373 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE SRC42A protein tyrosine kinase activity#GO:0004713;non-membrane spanning protein tyrosine kinase activity#GO:0004715;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein binding#GO:0005515;catalytic activity, acting on a protein#GO:0140096;signaling receptor binding#GO:0005102;kinase activity#GO:0016301;protein kinase activity#GO:0004672 response to external biotic stimulus#GO:0043207;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;immune response#GO:0006955;developmental process#GO:0032502;cell communication#GO:0007154;cellular process#GO:0009987;defense response to symbiont#GO:0140546;regulation of biological process#GO:0050789;immune system process#GO:0002376;response to stimulus#GO:0050896;response to external stimulus#GO:0009605;cell differentiation#GO:0030154;enzyme-linked receptor protein signaling pathway#GO:0007167;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to other organism#GO:0098542;regulation of cellular process#GO:0050794;response to other organism#GO:0051707;cell surface receptor signaling pathway#GO:0007166;biological process involved in interspecies interaction between organisms#GO:0044419;biological regulation#GO:0065007;innate immune response#GO:0045087;defense response#GO:0006952;signaling#GO:0023052;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169 non-receptor tyrosine protein kinase#PC00168 Parkinson disease#P00049>Src kinase#P01230;Integrin signalling pathway#P00034>Src#P00940 HELRO|EnsemblGenome=HelroG163700|UniProtKB=T1EUD2 T1EUD2 20200182 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG86568|UniProtKB=T1G6E0 T1G6E0 20216637 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182919|UniProtKB=T1FIX4 T1FIX4 20208773 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170382|UniProtKB=T1F2Z3 T1F2Z3 20203192 PTHR24243:SF230 G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG173246|UniProtKB=T1F6L5 T1F6L5 20204464 PTHR22629:SF0 ARP2/3 COMPLEX 20 KD SUBUNIT ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4 cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;Arp2/3 complex-mediated actin nucleation#GO:0034314;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;Arp2/3 protein complex#GO:0005885;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Arp2/3#P00876;Cytoskeletal regulation by Rho GTPase#P00016>ARP2/3#P00511 HELRO|EnsemblGenome=HelroG183980|UniProtKB=T1FKE0 T1FKE0 20209289 PTHR13070:SF0 TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34 catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;tRNA splicing, via endonucleolytic cleavage and ligation#GO:0006388;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG180146|UniProtKB=T1FFI6 T1FFI6 20207585 PTHR12011:SF347 ADHESION G-PROTEIN COUPLED RECEPTOR FI21270P1-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG184319|UniProtKB=T1FKZ5 T1FKZ5 20209494 PTHR33332:SF48 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG108821|UniProtKB=T1EEM8 T1EEM8 20195030 PTHR23033:SF14 BETA1,3-GALACTOSYLTRANSFERASE GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED galactosyltransferase activity#GO:0008378;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG106350|UniProtKB=T1EE23 T1EE23 20194825 PTHR11081:SF8 FLAP ENDONUCLEASE FAMILY MEMBER EXONUCLEASE 1 DNA endonuclease activity#GO:0004520;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824;endonuclease activity#GO:0004519;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097 DNA metabolism protein#PC00009;exodeoxyribonuclease#PC00098 HELRO|EnsemblGenome=HelroG185909|UniProtKB=T1FNF6 T1FNF6 20210353 PTHR23503:SF8 SOLUTE CARRIER FAMILY 2 FACILITATED GLUCOSE TRANSPORTER PROTEIN 1 transmembrane transporter activity#GO:0022857;sugar transmembrane transporter activity#GO:0051119;transporter activity#GO:0005215;carbohydrate transmembrane transporter activity#GO:0015144 localization#GO:0051179;organic substance transport#GO:0071702;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;cellular process#GO:0009987;carbohydrate transmembrane transport#GO:0034219;carbohydrate transport#GO:0008643 cellular anatomical entity#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG184940|UniProtKB=T1FM69 T1FM69 20209918 PTHR11028:SF0 VACUOLAR ATP SYNTHASE SUBUNIT AC39 V-TYPE PROTON ATPASE SUBUNIT D 1 regulation of intracellular pH#GO:0051453;cellular localization#GO:0051641;vacuolar transport#GO:0007034;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;regulation of pH#GO:0006885;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;intracellular monoatomic cation homeostasis#GO:0030003;biological regulation#GO:0065007;intracellular pH reduction#GO:0051452;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;intracellular monoatomic ion homeostasis#GO:0006873;regulation of cellular pH#GO:0030641;vacuolar acidification#GO:0007035 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;vacuolar membrane#GO:0005774;ATPase complex#GO:1904949;vacuole#GO:0005773;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;proton-transporting two-sector ATPase complex#GO:0016469;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG189657|UniProtKB=T1FR85 T1FR85 20211332 PTHR18945:SF925 NEUROTRANSMITTER GATED ION CHANNEL DUF4706 DOMAIN-CONTAINING PROTEIN ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG62537|UniProtKB=T1FX19 T1FX19 20213367 PTHR24204:SF8 INSULIN GENE ENHANCER PROTEIN TAILUP, ISOFORM A cellular developmental process#GO:0048869;neurogenesis#GO:0022008;cell projection organization#GO:0030030;multicellular organism development#GO:0007275;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;cell morphogenesis#GO:0000902;cellular component organization#GO:0016043;cell fate commitment#GO:0045165;cellular process#GO:0009987;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;cell fate specification#GO:0001708;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;cell differentiation#GO:0030154;system development#GO:0048731;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;neuron differentiation#GO:0030182;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;axonogenesis#GO:0007409;plasma membrane bounded cell projection morphogenesis#GO:0120039;generation of neurons#GO:0048699 HELRO|EnsemblGenome=HelroG141355|UniProtKB=T1EJ33 T1EJ33 20196583 PTHR24416:SF600 TYROSINE-PROTEIN KINASE RECEPTOR PDGF- AND VEGF-RECEPTOR RELATED, ISOFORM J signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG184519|UniProtKB=T1FLD8 T1FLD8 20209637 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170170|UniProtKB=T1F2Q8 T1F2Q8 20203107 PTHR16038:SF4 NOP SEVEN ASSOCIATED PROTEIN 1 WD REPEAT-CONTAINING PROTEIN 74 cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;ribosome biogenesis#GO:0042254;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;ribonucleoprotein complex biogenesis#GO:0022613 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;preribosome, large subunit precursor#GO:0030687;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG184238|UniProtKB=T1FKT9 T1FKT9 20209438 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164706|UniProtKB=T1EVR1 T1EVR1 20200661 PTHR45617:SF170 LEUCINE RICH REPEAT FAMILY PROTEIN MIP14966P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG172780|UniProtKB=T1F5Y0 T1F5Y0 20204229 PTHR11040:SF219 ZINC/IRON TRANSPORTER ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;transition metal ion transport#GO:0000041;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG112249|UniProtKB=T1EFI1 T1EFI1 20195333 PTHR28658:SF3 TRANSMEMBRANE PROTEIN 180 TRANSMEMBRANE PROTEIN 180 HELRO|EnsemblGenome=HelroG152313|UniProtKB=T1EKQ8 T1EKQ8 20197158 PTHR21346:SF0 FUN14 DOMAIN CONTAINING RE45833P process utilizing autophagic mechanism#GO:0061919;cellular component organization or biogenesis#GO:0071840;cellular component disassembly#GO:0022411;organelle organization#GO:0006996;catabolic process#GO:0009056;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;autophagy of mitochondrion#GO:0000422;mitochondrion organization#GO:0007005;cellular process#GO:0009987;organelle disassembly#GO:1903008;autophagy#GO:0006914;cellular catabolic process#GO:0044248;metabolic process#GO:0008152 envelope#GO:0031975;bounding membrane of organelle#GO:0098588;mitochondrial membrane#GO:0031966;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867 HELRO|EnsemblGenome=HelroG133386|UniProtKB=T1EI07 T1EI07 20196207 PTHR24416:SF600 TYROSINE-PROTEIN KINASE RECEPTOR PDGF- AND VEGF-RECEPTOR RELATED, ISOFORM J signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG182743|UniProtKB=T1FIN8 T1FIN8 20208687 PTHR10252:SF54 HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG73874|UniProtKB=T1G1J8 T1G1J8 20214946 PTHR10055:SF1 TRYPTOPHANYL-TRNA SYNTHETASE TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG69527|UniProtKB=T1FZW5 T1FZW5 20214363 PTHR31699:SF1 NUDIX T16 FAMILY MEMBER U8 SNORNA-DECAPPING ENZYME snoRNA binding#GO:0030515;catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;nuclease activity#GO:0004518;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;endonuclease activity#GO:0004519;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;regulation of biological process#GO:0050789;ncRNA metabolic process#GO:0034660;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;mRNA catabolic process#GO:0006402;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;negative regulation of cellular process#GO:0048523;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG191571|UniProtKB=T1FT33 T1FT33 20211980 PTHR18945:SF925 NEUROTRANSMITTER GATED ION CHANNEL DUF4706 DOMAIN-CONTAINING PROTEIN ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG90066|UniProtKB=T1G7K7 T1G7K7 20217054 PTHR10529:SF344 AP COMPLEX SUBUNIT MU PROTEIN STONED-B molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cellular localization#GO:0051641;regulation of endocytosis#GO:0030100;synaptic vesicle cycle#GO:0099504;synaptic vesicle endocytosis#GO:0048488;clathrin-dependent endocytosis#GO:0072583;endocytosis#GO:0006897;transport#GO:0006810;vesicle-mediated transport#GO:0016192;regulation of localization#GO:0032879;regulation of cellular component organization#GO:0051128;cellular process#GO:0009987;regulation of vesicle-mediated transport#GO:0060627;localization#GO:0051179;regulation of biological process#GO:0050789;synaptic vesicle recycling#GO:0036465;regulation of transport#GO:0051049;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;receptor-mediated endocytosis#GO:0006898;import into cell#GO:0098657;vesicle-mediated transport in synapse#GO:0099003 bounding membrane of organelle#GO:0098588;synapse#GO:0045202;intracellular membrane-bounded organelle#GO:0043231;synaptic vesicle#GO:0008021;plasma membrane protein complex#GO:0098797;clathrin vesicle coat#GO:0030125;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;AP-type membrane coat adaptor complex#GO:0030119;clathrin-coated vesicle#GO:0030136;membrane coat#GO:0030117;coated membrane#GO:0048475;cytoplasmic vesicle membrane#GO:0030659;clathrin-coated pit#GO:0005905;membrane protein complex#GO:0098796;presynapse#GO:0098793;intracellular vesicle#GO:0097708;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020;coated vesicle#GO:0030135;vesicle coat#GO:0030120;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;coated vesicle membrane#GO:0030662;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;transport vesicle#GO:0030133;endocytic vesicle#GO:0030139;secretory vesicle#GO:0099503;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG70073|UniProtKB=T1G023 T1G023 20214421 PTHR11937:SF16 ACTIN ACTIN-RELATED PROTEIN 5 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 Ino80 complex#GO:0031011;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;INO80-type complex#GO:0097346;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 actin and actin related protein#PC00039;cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG150433|UniProtKB=T1EKF7 T1EKF7 20197057 PTHR11875:SF7 TESTIS-SPECIFIC Y-ENCODED PROTEIN AT14585P-RELATED protein binding#GO:0005515;protein-containing complex binding#GO:0044877;histone binding#GO:0042393;binding#GO:0005488;chromatin binding#GO:0003682 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;nucleosome organization#GO:0034728;nucleosome assembly#GO:0006334;protein-containing complex organization#GO:0043933;protein-containing complex assembly#GO:0065003;chromatin organization#GO:0006325;cellular component organization#GO:0016043;protein-DNA complex assembly#GO:0065004;chromatin remodeling#GO:0006338;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG192005|UniProtKB=T1FTI1 T1FTI1 20212128 PTHR34756:SF1 CELL DIVISION CYCLE-ASSOCIATED PROTEIN 3 CELL DIVISION CYCLE-ASSOCIATED PROTEIN 3 HELRO|EnsemblGenome=HelroG155780|UniProtKB=T1ELM3 T1ELM3 20197473 PTHR24418:SF162 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE ABL protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG163839|UniProtKB=T1EUJ1 T1EUJ1 20200241 PTHR33273:SF4 DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188183|UniProtKB=T1FPR1 T1FPR1 20210808 PTHR13318:SF247 PARTNER OF PAIRED, ISOFORM B-RELATED GH16156P macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234 HELRO|EnsemblGenome=HelroG75793|UniProtKB=T1G2A3 T1G2A3 20215201 PTHR10983:SF73 1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE EPSILON transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;glycerolipid metabolic process#GO:0046486;cellular metabolic process#GO:0044237;phosphatidylinositol metabolic process#GO:0046488;organophosphate metabolic process#GO:0019637;glycerophospholipid metabolic process#GO:0006650;cellular process#GO:0009987;phospholipid metabolic process#GO:0006644;cellular lipid metabolic process#GO:0044255;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG194467|UniProtKB=T1FW31 T1FW31 20213027 PTHR12460:SF40 CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN REGULATION OF NUCLEAR PRE-MRNA DOMAIN-CONTAINING PROTEIN 2 basal RNA polymerase II transcription machinery binding#GO:0001099;RNA polymerase binding#GO:0070063;binding#GO:0005488;RNA polymerase core enzyme binding#GO:0043175;RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515;enzyme binding#GO:0019899;basal transcription machinery binding#GO:0001098 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;mRNA 3'-end processing#GO:0031124;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mRNA processing#GO:0006397;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 kinase modulator#PC00140;kinase inhibitor#PC00139 HELRO|EnsemblGenome=HelroG65782|UniProtKB=T1FYC6 T1FYC6 20213824 PTHR31634:SF2 BLOC-1-RELATED COMPLEX SUBUNIT 5 BLOC-1-RELATED COMPLEX SUBUNIT 5 regulation of microtubule-based process#GO:0032886;cellular localization#GO:0051641;organelle localization#GO:0051640;transport#GO:0006810;microtubule-based movement#GO:0007018;positive regulation of transport#GO:0051050;regulation of localization#GO:0032879;cellular process#GO:0009987;regulation of cellular localization#GO:0060341;transport along microtubule#GO:0010970;positive regulation of cellular process#GO:0048522;localization#GO:0051179;regulation of biological process#GO:0050789;lysosome localization#GO:0032418;microtubule-based transport#GO:0099111;regulation of transport#GO:0051049;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;cytoskeleton-dependent intracellular transport#GO:0030705;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;positive regulation of biological process#GO:0048518;organelle transport along microtubule#GO:0072384;establishment of organelle localization#GO:0051656 bounding membrane of organelle#GO:0098588;lytic vacuole membrane#GO:0098852;synapse#GO:0045202;intracellular membrane-bounded organelle#GO:0043231;synaptic vesicle#GO:0008021;vacuole#GO:0005773;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;transport vesicle membrane#GO:0030658;lysosome#GO:0005764;cytoplasmic vesicle membrane#GO:0030659;synaptic vesicle membrane#GO:0030672;presynapse#GO:0098793;intracellular vesicle#GO:0097708;vacuolar membrane#GO:0005774;cell junction#GO:0030054;membrane#GO:0016020;lytic vacuole#GO:0000323;side of membrane#GO:0098552;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;lysosomal membrane#GO:0005765;protein-containing complex#GO:0032991;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;secretory vesicle#GO:0099503 HELRO|EnsemblGenome=HelroG77826|UniProtKB=T1G347 T1G347 20215495 PTHR12294:SF1 EF HAND DOMAIN FAMILY A1,A2-RELATED CALCIUM UPTAKE PROTEIN 1, MITOCHONDRIAL cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;calcium ion transport#GO:0006816;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;mitochondrial transport#GO:0006839;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation transport#GO:0006812;mitochondrial calcium ion homeostasis#GO:0051560;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;mitochondrial transmembrane transport#GO:1990542;monoatomic cation transmembrane transport#GO:0098655 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;transporter complex#GO:1990351;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;calcium channel complex#GO:0034704;membrane#GO:0016020;organelle envelope#GO:0031967;cation channel complex#GO:0034703;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;mitochondrial envelope#GO:0005740;transmembrane transporter complex#GO:1902495;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;mitochondrial protein-containing complex#GO:0098798 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG65956|UniProtKB=T1FYF0 T1FYF0 20213848 PTHR15574:SF40 WD REPEAT DOMAIN-CONTAINING FAMILY WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of lipid metabolic process#GO:0019216;regulation of lipid biosynthetic process#GO:0046890;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;negative regulation of cellular biosynthetic process#GO:0031327 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;Cul4-RING E3 ubiquitin ligase complex#GO:0080008 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG161002|UniProtKB=T1EQZ7 T1EQZ7 20198997 PTHR14226:SF79 NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;phospholipase activity#GO:0004620;catalytic activity#GO:0003824;lysophospholipase activity#GO:0004622 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 esterase#PC00097;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG173029|UniProtKB=T1F6A1 T1F6A1 20204350 PTHR10075:SF100 BASIGIN RELATED FASCICLIN-2 cell adhesion molecule binding#GO:0050839;cell-cell adhesion mediator activity#GO:0098632;protein binding#GO:0005515;binding#GO:0005488 neuron projection guidance#GO:0097485;cell recognition#GO:0008037;neurogenesis#GO:0022008;cell projection organization#GO:0030030;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;axonogenesis#GO:0007409;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156;cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cell morphogenesis#GO:0000902;cellular process#GO:0009987;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure development#GO:0048856;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;axon#GO:0030424 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG188923|UniProtKB=T1FQH3 T1FQH3 20211070 PTHR43294:SF13 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium ion transmembrane transporter activity#GO:0015079;sodium ion transmembrane transporter activity#GO:0015081;P-type ion transporter activity#GO:0015662;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075 inorganic ion homeostasis#GO:0098771;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;proton transmembrane transport#GO:1902600;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;sodium ion homeostasis#GO:0055078;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;import into cell#GO:0098657;monoatomic cation transmembrane transport#GO:0098655;export from cell#GO:0140352;sodium ion transmembrane transport#GO:0035725;potassium ion import across plasma membrane#GO:1990573;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG66308|UniProtKB=T1FYJ6 T1FYJ6 20213894 PTHR24543:SF334 MULTICOPPER OXIDASE-RELATED F5_8 TYPE C DOMAIN-CONTAINING PROTEIN oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG169921|UniProtKB=T1F2G2 T1F2G2 20203012 PTHR11142:SF5 PSEUDOURIDYLATE SYNTHASE TRNA PSEUDOURIDINE(38_39) SYNTHASE isomerase activity#GO:0016853;intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;mRNA modification#GO:0016556;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;pseudouridine synthesis#GO:0001522;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 lyase#PC00144 HELRO|EnsemblGenome=HelroG72350|UniProtKB=T1G0Y8 T1G0Y8 20214736 PTHR45973:SF8 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED LEUCINE-RICH REPEAT-CONTAINING PROTEIN 49 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG172003|UniProtKB=T1F4X6 T1F4X6 20203875 PTHR34639:SF1 PROTEIN FLATTOP PROTEIN FLATTOP cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;cellular component organization#GO:0016043;cellular process#GO:0009987;cell projection organization#GO:0030030;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cilium#GO:0005929;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG89836|UniProtKB=T1G7I2 T1G7I2 20217029 PTHR11829:SF402 FORKHEAD BOX PROTEIN FORK HEAD DOMAIN-CONTAINING PROTEIN FD3-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;anatomical structure morphogenesis#GO:0009653;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG173278|UniProtKB=T1F6M6 T1F6M6 20204475 PTHR16021:SF20 MANSC DOMAIN CONTAINING PROTEIN 1 C3H1-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77635|UniProtKB=T1G313 T1G313 20215461 PTHR11920:SF501 GUANYLYL CYCLASE GUANYLATE CYCLASE 32E adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG64770|UniProtKB=T1FXY9 T1FXY9 20213687 PTHR11537:SF252 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;delayed rectifier potassium channel activity#GO:0005251;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG177152|UniProtKB=T1FBA1 T1FBA1 20206100 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED FMRFAMIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG108613|UniProtKB=T1EEK9 T1EEK9 20195011 PTHR18945:SF865 NEUROTRANSMITTER GATED ION CHANNEL NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA7, ISOFORM E ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG147750|UniProtKB=T1EK26 T1EK26 20196926 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN SI:DKEY-17M8.2 HELRO|EnsemblGenome=HelroG177855|UniProtKB=T1FCD5 T1FCD5 20206484 PTHR46545:SF1 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 51 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 51 HELRO|EnsemblGenome=HelroG69468|UniProtKB=T1FZV6 T1FZV6 20214354 PTHR21713:SF4 NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED GH09281P-RELATED protein binding#GO:0005515;unfolded protein binding#GO:0051082;binding#GO:0005488 localization#GO:0051179;establishment of protein localization to membrane#GO:0090150;localization within membrane#GO:0051668;protein targeting to membrane#GO:0006612;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;protein localization to membrane#GO:0072657;protein targeting#GO:0006605;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG93282|UniProtKB=T1G8U9 T1G8U9 20217496 PTHR10286:SF3 INORGANIC PYROPHOSPHATASE INORGANIC PYROPHOSPHATASE hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824 cellular metabolic process#GO:0044237;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;metabolic process#GO:0008152 pyrophosphatase#PC00196 HELRO|EnsemblGenome=HelroG134157|UniProtKB=T1EI34 T1EI34 20196234 PTHR11409:SF39 ADENOSINE DEAMINASE ADENOSINE DEAMINASE 2 hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;adenosine deaminase activity#GO:0004000;deaminase activity#GO:0019239;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;nucleoside metabolic process#GO:0009116;glycosyl compound catabolic process#GO:1901658;carbohydrate derivative metabolic process#GO:1901135;heterocycle catabolic process#GO:0046700;organonitrogen compound catabolic process#GO:1901565;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase metabolic process#GO:0009112;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;purine-containing compound catabolic process#GO:0072523;organic cyclic compound metabolic process#GO:1901360;purine nucleoside metabolic process#GO:0042278;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;purine-containing compound metabolic process#GO:0072521;catabolic process#GO:0009056;nucleoside catabolic process#GO:0009164;organic substance catabolic process#GO:1901575;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;carbohydrate derivative catabolic process#GO:1901136;purine nucleobase metabolic process#GO:0006144;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;purine nucleoside catabolic process#GO:0006152;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;aromatic compound catabolic process#GO:0019439;nucleobase-containing compound biosynthetic process#GO:0034654;small molecule catabolic process#GO:0044282;nucleobase-containing small molecule catabolic process#GO:0034656;adenosine metabolic process#GO:0046085;organic cyclic compound catabolic process#GO:1901361;aromatic compound biosynthetic process#GO:0019438;small molecule biosynthetic process#GO:0044283;nucleobase-containing compound catabolic process#GO:0034655;glycosyl compound metabolic process#GO:1901657;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 deaminase#PC00088;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG173001|UniProtKB=T1F692 T1F692 20204341 PTHR24336:SF8 TRANSCRIPTION FACTOR LBX LADYBIRD EARLY-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG109006|UniProtKB=T1EEP9 T1EEP9 20195051 PTHR21422:SF9 RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG178975|UniProtKB=T1FDZ7 T1FDZ7 20207046 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG112873|UniProtKB=T1EFM7 T1EFM7 20195379 PTHR11777:SF9 ALANYL-TRNA SYNTHETASE ALANINE--TRNA LIGASE, CYTOPLASMIC catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG188000|UniProtKB=T1FPJ2 T1FPJ2 20210739 PTHR14110:SF18 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22 OUTER ENVELOPE PORE PROTEIN 16-3, CHLOROPLASTIC_MITOCHONDRIAL transporter#PC00227 HELRO|EnsemblGenome=HelroG195039|UniProtKB=T1FWP2 T1FWP2 20213237 PTHR11119:SF3 XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER LD30822P transporter#PC00227 HELRO|EnsemblGenome=HelroG86108|UniProtKB=T1G675 T1G675 20216572 PTHR11129:SF2 PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA prenyltransferase activity#GO:0004659;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;protein modification process#GO:0036211;cellular process#GO:0009987;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;transferase complex#GO:1990234 acyltransferase#PC00042;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG188312|UniProtKB=T1FPV1 T1FPV1 20210848 PTHR24228:SF59 B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR NEUROPEPTIDE RECEPTOR 15 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG83726|UniProtKB=T1G597 T1G597 20216244 PTHR10828:SF76 M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25 M-PHASE INDUCER PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 regulation of cell cycle G2/M phase transition#GO:1902749;mitotic cell cycle phase transition#GO:0044772;regulation of mitotic cell cycle phase transition#GO:1901990;cell cycle process#GO:0022402;regulation of cell cycle phase transition#GO:1901987;positive regulation of cell cycle#GO:0045787;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047;cell cycle phase transition#GO:0044770;positive regulation of cellular process#GO:0048522;regulation of cell cycle process#GO:0010564;regulation of biological process#GO:0050789;G2/M transition of mitotic cell cycle#GO:0000086;mitotic cell cycle#GO:0000278;regulation of meiotic cell cycle#GO:0051445;regulation of cellular process#GO:0050794;positive regulation of cell cycle process#GO:0090068;positive regulation of mitotic cell cycle#GO:0045931;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of G2/M transition of mitotic cell cycle#GO:0010389;positive regulation of biological process#GO:0048518;regulation of mitotic cell cycle#GO:0007346;cell cycle G2/M phase transition#GO:0044839 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG68275|UniProtKB=T1FZC5 T1FZC5 20214173 PTHR19134:SF561 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG166756|UniProtKB=T1EYH0 T1EYH0 20201620 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175212|UniProtKB=T1F907 T1F907 20205306 PTHR22146:SF17 CAT EYE SYNDROME CRITICAL REGION PROTEIN 6 PROTEIN FAM166B-LIKE PROTEIN HELRO|EnsemblGenome=HelroG87901|UniProtKB=T1G6W4 T1G6W4 20216811 PTHR23122:SF7 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK PERIPHERAL PLASMA MEMBRANE PROTEIN CASK protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 regulation of cell communication#GO:0010646;cellular localization#GO:0051641;macromolecule localization#GO:0033036;regulation of signaling#GO:0023051;regulation of localization#GO:0032879;regulation of secretion by cell#GO:1903530;cellular process#GO:0009987;regulation of neurotransmitter secretion#GO:0046928;protein localization#GO:0008104;regulation of biological process#GO:0050789;localization#GO:0051179;regulation of transport#GO:0051049;cellular macromolecule localization#GO:0070727;regulation of cellular process#GO:0050794;regulation of secretion#GO:0051046;modulation of chemical synaptic transmission#GO:0050804;biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177 cell junction#GO:0030054;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911;anchoring junction#GO:0070161;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 Parkinson disease#P00049>CASK#P01232;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CaMK#P00847 HELRO|EnsemblGenome=HelroG174775|UniProtKB=T1F8G4 T1F8G4 20205113 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185499|UniProtKB=T1FMW4 T1FMW4 20210163 PTHR24068:SF143 UBIQUITIN-CONJUGATING ENZYME E2 GEO06356P1 ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;postreplication repair#GO:0006301;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;post-translational protein modification#GO:0043687;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;response to stress#GO:0006950;nitrogen compound metabolic process#GO:0006807;protein polyubiquitination#GO:0000209;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;protein K63-linked ubiquitination#GO:0070534;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Toll receptor signaling pathway#P00054>Uev1A#P01376;Ubiquitin proteasome pathway#P00060>E2#P01491 HELRO|EnsemblGenome=HelroG181401|UniProtKB=T1FGY9 T1FGY9 20208088 PTHR15034:SF5 DEATH DOMAIN-CONTAINING PROTEIN CRADD DEATH DOMAIN-CONTAINING PROTEIN CRADD Wnt signaling pathway#P00057>Frizzled#P01428;Apoptosis signaling pathway#P00006>RAIDD#P00294;Cadherin signaling pathway#P00012>Frizzled#P00475;Alzheimer disease-presenilin pathway#P00004>Frizzled#P00119 HELRO|EnsemblGenome=HelroG155821|UniProtKB=T1ELM7 T1ELM7 20197477 PTHR11001:SF2 MITOCHONDRIAL FISSION PROCESS PROTEIN 1 MITOCHONDRIAL FISSION PROCESS PROTEIN 1 cellular component organization or biogenesis#GO:0071840;organelle fission#GO:0048285;mitochondrion organization#GO:0007005;cellular component organization#GO:0016043;cellular process#GO:0009987;organelle organization#GO:0006996;mitochondrial fission#GO:0000266 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG71201|UniProtKB=T1G0H7 T1G0H7 20214575 PTHR20935:SF0 PHOSPHOGLYCERATE MUTASE-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE PGAM5, MITOCHONDRIAL mutase#PC00160 HELRO|EnsemblGenome=HelroG75027|UniProtKB=T1G1Z5 T1G1Z5 20215093 PTHR45620:SF1 PDF RECEPTOR-LIKE PROTEIN-RELATED G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;peptide hormone binding#GO:0017046;binding#GO:0005488;peptide binding#GO:0042277;amide binding#GO:0033218;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled peptide receptor activity#GO:0008528;hormone binding#GO:0042562;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG191433|UniProtKB=T1FSZ2 T1FSZ2 20211939 PTHR31395:SF25 SHISA ABLIM_ANCHOR DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG112012|UniProtKB=T1EFG4 T1EFG4 20195316 PTHR20933:SF4 F-BOX ONLY PROTEIN 33 F-BOX INVOLVED IN POLYQ PATHOGENESIS, ISOFORM A HELRO|EnsemblGenome=HelroG170907|UniProtKB=T1F3L0 T1F3L0 20203409 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cell communication#GO:0007154;cellular process#GO:0009987;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;Notch signaling pathway#GO:0007219 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG69247|UniProtKB=T1FZR8 T1FZR8 20214316 PTHR13193:SF0 CGI-140 PAT COMPLEX SUBUNIT ASTERIX protein insertion into ER membrane#GO:0045048;localization within membrane#GO:0051668;cellular localization#GO:0051641;endoplasmic reticulum organization#GO:0007029;macromolecule localization#GO:0033036;membrane organization#GO:0061024;protein localization to membrane#GO:0072657;endomembrane system organization#GO:0010256;cellular component organization#GO:0016043;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to membrane#GO:0090150;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;organelle organization#GO:0006996;protein localization to organelle#GO:0033365;protein insertion into membrane#GO:0051205 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185194|UniProtKB=T1FMH7 T1FMH7 20210026 PTHR11778:SF7 SERYL-TRNA SYNTHETASE SERINE--TRNA LIGASE, CYTOPLASMIC aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG162122|UniProtKB=T1ES93 T1ES93 20199443 PTHR12154:SF4 GLYCOSYL TRANSFERASE-RELATED UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG acetylglucosaminyltransferase activity#GO:0008375;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;organic hydroxy compound metabolic process#GO:1901615;macromolecule glycosylation#GO:0043413;lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;alcohol metabolic process#GO:0006066;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;isoprenoid metabolic process#GO:0006720;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;cellular lipid metabolic process#GO:0044255;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;small molecule metabolic process#GO:0044281;glycosylation#GO:0070085;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG78542|UniProtKB=T1G3C8 T1G3C8 20215576 PTHR47633:SF4 IMMUNOGLOBULIN MYOPALLADIN ISOFORM X1 HELRO|EnsemblGenome=HelroG169837|UniProtKB=T1F2D1 T1F2D1 20202981 PTHR42264:SF3 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN F-BOX DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG64665|UniProtKB=T1FXX7 T1FXX7 20213675 PTHR23257:SF981 SERINE-THREONINE PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG188887|UniProtKB=T1FQF8 T1FQF8 20211055 PTHR22923:SF116 CEREBELLIN-RELATED C1Q DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG176740|UniProtKB=T1FAV1 T1FAV1 20205950 PTHR31935:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 13 COILED-COIL DOMAIN-CONTAINING PROTEIN 13 HELRO|EnsemblGenome=HelroG82261|UniProtKB=T1G4P8 T1G4P8 20216046 PTHR45701:SF3 SYNAPTOBREVIN FAMILY MEMBER SYNAPTOBREVIN syntaxin binding#GO:0019905;molecular adaptor activity#GO:0060090;protein binding#GO:0005515;SNAP receptor activity#GO:0005484;binding#GO:0005488;SNARE binding#GO:0000149;protein-macromolecule adaptor activity#GO:0030674 localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;vesicle fusion#GO:0006906;membrane fusion#GO:0061025;establishment of localization#GO:0051234;membrane organization#GO:0061024;organelle organization#GO:0006996;organelle membrane fusion#GO:0090174;transport#GO:0006810;vesicle-mediated transport#GO:0016192;vesicle organization#GO:0016050;cellular component organization#GO:0016043;cellular process#GO:0009987;organelle fusion#GO:0048284 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;SNARE complex#GO:0031201;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 Opioid proenkephalin pathway#P05915>SNARE Complex#P05986;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066;Thyrotropin-releasing hormone receptor signaling pathway#P04394>SNARE Complex#P04582;Dopamine receptor mediated signaling pathway#P05912>SNARE Complex#P05956;Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072;Beta3 adrenergic receptor signaling pathway#P04379>SNARE Complex#P04447;5HT4 type receptor mediated signaling pathway#P04376>SNARE Complex#P04428;Opioid prodynorphin pathway#P05916>SNARE Complex#P05996;Alpha adrenergic receptor signaling pathway#P00002>SNARE#P00074;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;5HT3 type receptor mediated signaling pathway#P04375>SNARE Complex#P04423;Ionotropic glutamate receptor pathway#P00037>SNARE Complex#P01013;Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049;Opioid proopiomelanocortin pathway#P05917>SNARE Complex#P06005;Beta1 adrenergic receptor signaling pathway#P04377>SNARE Complex#P04435;Cortocotropin releasing factor receptor signaling pathway#P04380>SNARE Complex#P04457;Metabotropic glutamate receptor group III pathway#P00039>SNARE Complex#P01042;Oxytocin receptor mediated signaling pathway#P04391>SNARE Complex#P04532;5HT2 type receptor mediated signaling pathway#P04374>SNARE Complex#P04415;5HT1 type receptor mediated signaling pathway#P04373>SNARE Complex#P04405;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;Beta2 adrenergic receptor signaling pathway#P04378>SNARE Complex#P04442 HELRO|EnsemblGenome=HelroG188911|UniProtKB=T1FQH0 T1FQH0 20211067 PTHR46227:SF2 GLUTAMATE RECEPTOR-INTERACTING PROTEIN GRIP FI03335P protein localization to plasma membrane#GO:0072659;endosomal transport#GO:0016197;localization within membrane#GO:0051668;cellular localization#GO:0051641;vesicle-mediated transport to the plasma membrane#GO:0098876;macromolecule localization#GO:0033036;protein localization to synapse#GO:0035418;protein localization to membrane#GO:0072657;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;protein localization to cell periphery#GO:1990778;establishment of protein localization to membrane#GO:0090150;organic substance transport#GO:0071702;endocytic recycling#GO:0032456;cellular macromolecule localization#GO:0070727;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;neurotransmitter receptor transport to postsynaptic membrane#GO:0098969;protein localization to cell junction#GO:1902414;protein transport#GO:0015031;biological regulation#GO:0065007;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;protein-containing complex localization#GO:0031503 HELRO|EnsemblGenome=HelroG178280|UniProtKB=T1FD11 T1FD11 20206710 PTHR19282:SF544 TETRASPANIN TETRASPANIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG175946|UniProtKB=T1F9Y1 T1F9Y1 20205630 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG81550|UniProtKB=T1G4F7 T1G4F7 20215955 PTHR23506:SF23 GH10249P GH10249P secondary carrier transporter#PC00258;transporter#PC00227 Adrenaline and noradrenaline biosynthesis#P00001>VAT1#P00071;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>VAChT#P01078;5HT3 type receptor mediated signaling pathway#P04375>5HT vesicular transporter#P04424;5HT2 type receptor mediated signaling pathway#P04374>5HT vesicular transporter#P04418;Nicotinic acetylcholine receptor signaling pathway#P00044>VAChT#P01089;5HT4 type receptor mediated signaling pathway#P04376>5HT vesicular transporter#P04432;5HT1 type receptor mediated signaling pathway#P04373>5HT vesicular transporter#P04410 HELRO|EnsemblGenome=HelroG67950|UniProtKB=T1FZ83 T1FZ83 20214131 PTHR24072:SF168 RHO FAMILY GTPASE RAS-LIKE GTP-BINDING PROTEIN RHO1 GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;enzyme binding#GO:0019899;ribonucleoside triphosphate phosphatase activity#GO:0017111;kinase binding#GO:0019900;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817;protein kinase binding#GO:0019901;anion binding#GO:0043168;ion binding#GO:0043167 regulation of biological process#GO:0050789;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;regulation of organelle organization#GO:0033043;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;regulation of actin filament-based process#GO:0032970;regulation of cellular component organization#GO:0051128 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 small GTPase#PC00208 Ras Pathway#P04393>Rho#P04578;Integrin signalling pathway#P00034>Rho#P00948;Angiogenesis#P00005>GTPase#P00254;Axon guidance mediated by Slit/Robo#P00008>Rho#P00355;Cytoskeletal regulation by Rho GTPase#P00016>Rho#P00507 HELRO|EnsemblGenome=HelroG195118|UniProtKB=T1FWR7 T1FWR7 20213262 PTHR12039:SF0 NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 cellular aromatic compound metabolic process#GO:0006725;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;pyridine nucleotide metabolic process#GO:0019362;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;nucleotide biosynthetic process#GO:0009165;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;nicotinamide nucleotide metabolic process#GO:0046496;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 nucleotidyltransferase#PC00174 HELRO|EnsemblGenome=HelroG173597|UniProtKB=T1F703 T1F703 20204602 PTHR47032:SF1 UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG171793|UniProtKB=T1F4P3 T1F4P3 20203792 PTHR13815:SF7 GOLGIN-84 GOLGIN SUBFAMILY A MEMBER 5 localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;Golgi organization#GO:0007030;establishment of localization#GO:0051234;intra-Golgi vesicle-mediated transport#GO:0006891;organelle organization#GO:0006996;transport#GO:0006810;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193 bounding membrane of organelle#GO:0098588;Golgi cisterna#GO:0031985;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;Golgi stack#GO:0005795;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791;Golgi membrane#GO:0000139 HELRO|EnsemblGenome=HelroG158868|UniProtKB=T1ENC6 T1ENC6 20198076 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180221|UniProtKB=T1FFL1 T1FFL1 20207610 PTHR24410:SF23 HL07962P-RELATED BTB DOMAIN-CONTAINING PROTEIN-RELATED defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG174769|UniProtKB=T1F8G1 T1F8G1 20205110 PTHR13287:SF2 ADIPOSE-SECRETED SIGNALING PROTEIN ADIPOSE-SECRETED SIGNALING PROTEIN HELRO|EnsemblGenome=HelroG72321|UniProtKB=T1G0Y2 T1G0Y2 20214730 PTHR11635:SF152 CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 kinase modulator#PC00140 Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Cell cycle#P00013>Protein kinase subunit#P00482;GABA-B receptor II signaling#P05731>PKA#P05752;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Enkephalin release#P05913>PKA#P05972;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Transcription regulation by bZIP transcription factor#P00055>PKA#P01384;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Hedgehog signaling pathway#P00025>PKA#P00682;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059;Endothelin signaling pathway#P00019>PKA#P00570 HELRO|EnsemblGenome=HelroG70039|UniProtKB=T1G018 T1G018 20214416 PTHR22760:SF1 GLYCOSYLTRANSFERASE DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE mannosyltransferase activity#GO:0000030;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG79133|UniProtKB=T1G3K6 T1G3K6 20215654 PTHR45810:SF1 HISTONE H3.2 HISTONE H3-LIKE CENTROMERIC PROTEIN A chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG67518|UniProtKB=T1FZ21 T1FZ21 20214069 PTHR46255:SF3 SHORT STATURE HOMEOBOX HOMEOBOX DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG158807|UniProtKB=T1ENA3 T1ENA3 20198053 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG155720|UniProtKB=T1ELL4 T1ELL4 20197464 PTHR16705:SF4 COMPLEXIN COMPLEXIN protein binding#GO:0005515;binding#GO:0005488;SNARE binding#GO:0000149 SNARE complex#GO:0031201;cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG181307|UniProtKB=T1FGV7 T1FGV7 20208056 PTHR31718:SF60 PLAT DOMAIN-CONTAINING PROTEIN LIPOXYGENASE HOMOLOGY DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG176838|UniProtKB=T1FAY3 T1FAY3 20205982 PTHR46224:SF64 ANKYRIN REPEAT FAMILY PROTEIN IQ MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG164644|UniProtKB=T1EVN9 T1EVN9 20200639 PTHR22761:SF10 CHARGED MULTIVESICULAR BODY PROTEIN GH13992P endosomal transport#GO:0016197;cellular localization#GO:0051641;membrane organization#GO:0061024;vacuolar transport#GO:0007034;transport#GO:0006810;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;vesicle-mediated transport#GO:0016192;late endosome to vacuole transport#GO:0045324;cellular component organization#GO:0016043;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;vesicle budding from membrane#GO:0006900;establishment of localization#GO:0051234;organelle organization#GO:0006996;endosome transport via multivesicular body sorting pathway#GO:0032509;establishment of localization in cell#GO:0051649;vesicle organization#GO:0016050;intracellular transport#GO:0046907 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;endosome membrane#GO:0010008;membrane#GO:0016020;side of membrane#GO:0098552;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG165256|UniProtKB=T1EWI3 T1EWI3 20200933 PTHR14445:SF36 GRB10 INTERACTING GYF PROTEIN FI03272P-RELATED cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG73484|UniProtKB=T1G1E2 T1G1E2 20214890 PTHR21314:SF0 QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;tRNA metabolic process#GO:0006399;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG107032|UniProtKB=T1EE66 T1EE66 20194868 PTHR24073:SF1216 DRAB5-RELATED RAS-RELATED PROTEIN RAB-5C GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 localization#GO:0051179;organic substance transport#GO:0071702;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;protein transport#GO:0015031;nitrogen compound transport#GO:0071705;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG167366|UniProtKB=T1EZB2 T1EZB2 20201912 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;heme binding#GO:0020037 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG128993|UniProtKB=T1EHR1 T1EHR1 20196111 PTHR45628:SF7 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated calcium channel activity#GO:0005245;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;calcium ion transport#GO:0006816;localization#GO:0051179;calcium ion import#GO:0070509;import across plasma membrane#GO:0098739;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;calcium ion transmembrane import into cytosol#GO:0097553;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657 voltage-gated calcium channel complex#GO:0005891;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;calcium channel complex#GO:0034704;membrane#GO:0016020;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 Ionotropic glutamate receptor pathway#P00037>Ca2+ channel#P01022;Thyrotropin-releasing hormone receptor signaling pathway#P04394>Ca2+ channel#P04587;Metabotropic glutamate receptor group II pathway#P00040>Ca2+#P01051;Metabotropic glutamate receptor group III pathway#P00039>Ca2+#P01041 HELRO|EnsemblGenome=HelroG70002|UniProtKB=T1G013 T1G013 20214411 PTHR46289:SF17 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG111363|UniProtKB=T1EFA6 T1EFA6 20195258 PTHR11654:SF509 OLIGOPEPTIDE TRANSPORTER-RELATED SOLUTE CARRIER FAMILY 15 MEMBER 4 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG97629|UniProtKB=T1G9I1 T1G9I1 20217728 PTHR11662:SF40 SOLUTE CARRIER FAMILY 17 MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810;monoatomic anion transport#GO:0006820 cellular anatomical entity#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG73579|UniProtKB=T1G1G0 T1G1G0 20214908 PTHR11893:SF36 INNEXIN INNEXIN-5 cell junction protein#PC00070;gap junction#PC00105 HELRO|EnsemblGenome=HelroG109171|UniProtKB=T1EEQ9 T1EEQ9 20195061 PTHR10177:SF344 CYCLINS G1_S-SPECIFIC CYCLIN-E protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234 regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;mitotic cell cycle phase transition#GO:0044772;regulation of nitrogen compound metabolic process#GO:0051171;cell cycle G1/S phase transition#GO:0044843;cell cycle process#GO:0022402;positive regulation of cell cycle#GO:0045787;positive regulation of cell cycle G1/S phase transition#GO:1902808;regulation of catalytic activity#GO:0050790;mitotic cell cycle process#GO:1903047;G1/S transition of mitotic cell cycle#GO:0000082;regulation of phosphorus metabolic process#GO:0051174;regulation of biological process#GO:0050789;mitotic cell cycle#GO:0000278;regulation of molecular function#GO:0065009;positive regulation of cell cycle process#GO:0090068;positive regulation of mitotic cell cycle#GO:0045931;regulation of protein serine/threonine kinase activity#GO:0071900;regulation of G1/S transition of mitotic cell cycle#GO:2000045;positive regulation of biological process#GO:0048518;regulation of cyclin-dependent protein serine/threonine kinase activity#GO:0000079;regulation of kinase activity#GO:0043549;regulation of protein kinase activity#GO:0045859;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of cell cycle phase transition#GO:1901987;cellular process#GO:0009987;cell cycle phase transition#GO:0044770;regulation of cell cycle process#GO:0010564;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule metabolic process#GO:0060255;regulation of protein phosphorylation#GO:0001932;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of phosphorylation#GO:0042325;regulation of mitotic cell cycle#GO:0007346;regulation of transferase activity#GO:0051338;regulation of cell cycle G1/S phase transition#GO:1902806;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 microtubule organizing center#GO:0005815;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;centrosome#GO:0005813;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856 kinase activator#PC00138 Cell cycle#P00013>CdkC#P00489;p53 pathway#P00059>Cyclin E#P04610;p53 pathway feedback loops 2#P04398>cyclin E#P04664;Cell cycle#P00013>Cyclin E#P00483 HELRO|EnsemblGenome=HelroG177427|UniProtKB=T1FBP1 T1FBP1 20206240 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG74357|UniProtKB=T1G1Q0 T1G1Q0 20214998 PTHR22880:SF225 FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED protein binding#GO:0005515;histone binding#GO:0042393;binding#GO:0005488;modification-dependent protein binding#GO:0140030 protein-DNA complex organization#GO:0071824;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;cellular component organization#GO:0016043;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG175963|UniProtKB=T1F9Z2 T1F9Z2 20206289 PTHR33562:SF28 ATILLA, ISOFORM B-RELATED-RELATED PROTEIN QUIVER HELRO|EnsemblGenome=HelroG155763|UniProtKB=T1ELM1 T1ELM1 20197471 PTHR22761:SF10 CHARGED MULTIVESICULAR BODY PROTEIN GH13992P endosomal transport#GO:0016197;cellular localization#GO:0051641;membrane organization#GO:0061024;vacuolar transport#GO:0007034;transport#GO:0006810;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;vesicle-mediated transport#GO:0016192;late endosome to vacuole transport#GO:0045324;cellular component organization#GO:0016043;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;vesicle budding from membrane#GO:0006900;establishment of localization#GO:0051234;organelle organization#GO:0006996;endosome transport via multivesicular body sorting pathway#GO:0032509;establishment of localization in cell#GO:0051649;vesicle organization#GO:0016050;intracellular transport#GO:0046907 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;endosome membrane#GO:0010008;membrane#GO:0016020;side of membrane#GO:0098552;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG170143|UniProtKB=T1F2P8 T1F2P8 20203097 PTHR28663:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 173 CILIA- AND FLAGELLA- ASSOCIATED PROTEIN 210 HELRO|EnsemblGenome=HelroG186106|UniProtKB=T1FNN6 T1FNN6 20210433 PTHR13120:SF0 PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 catalytic step 2 spliceosome#GO:0071013;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;U2 snRNP#GO:0005686;membrane-bounded organelle#GO:0043227;precatalytic spliceosome#GO:0071011;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG179140|UniProtKB=T1FE83 T1FE83 20207132 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG71298|UniProtKB=T1G0J2 T1G0J2 20214590 PTHR12805:SF0 KIN17 KIN, ANTIGENIC DETERMINANT OF RECA PROTEIN HOMOLOG DNA_RNA-BINDING PROTEIN KIN17 nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;response to stress#GO:0006950;nitrogen compound metabolic process#GO:0006807;DNA replication#GO:0006260;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG75022|UniProtKB=T1G1Z4 T1G1Z4 20215092 PTHR23338:SF18 SMALL NUCLEAR RIBONUCLEOPROTEIN SM SMALL NUCLEAR RIBONUCLEOPROTEIN SM D1 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;organic cyclic compound metabolic process#GO:1901360;mRNA metabolic process#GO:0016071;nitrogen compound metabolic process#GO:0006807;spliceosomal snRNP assembly#GO:0000387;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375 catalytic step 2 spliceosome#GO:0071013;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;U1 snRNP#GO:0005685;U2-type spliceosomal complex#GO:0005684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;U4 snRNP#GO:0005687;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;U5 snRNP#GO:0005682;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;SMN-Sm protein complex#GO:0034719;ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;pICln-Sm protein complex#GO:0034715;U2 snRNP#GO:0005686;spliceosomal tri-snRNP complex#GO:0097526;precatalytic spliceosome#GO:0071011;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG74170|UniProtKB=T1G1M9 T1G1M9 20214977 PTHR42884:SF23 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED FURIN-LIKE PROTEASE 2 hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 bounding membrane of organelle#GO:0098588;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791;Golgi membrane#GO:0000139 serine protease#PC00203;protein modifying enzyme#PC00260 Endothelin signaling pathway#P00019>furin#P00575;Alzheimer disease-presenilin pathway#P00004>Furin#P00157;Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105 HELRO|EnsemblGenome=HelroG182833|UniProtKB=T1FIU0 T1FIU0 20208739 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED BRCT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174453|UniProtKB=T1F851 T1F851 20205000 PTHR12425:SF5 SYNEMBRYN SYNEMBRYN nucleoside-triphosphatase regulator activity#GO:0060589;protein binding#GO:0005515;GTPase regulator activity#GO:0030695;binding#GO:0005488;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG181891|UniProtKB=T1FHF8 T1FHF8 20208257 PTHR23147:SF133 SERINE/ARGININE RICH SPLICING FACTOR SERINE_ARGININE-RICH SPLICING FACTOR 10 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;nuclear speck#GO:0016607;organelle#GO:0043226;nuclear body#GO:0016604;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG181777|UniProtKB=T1FHB3 T1FHB3 20208212 PTHR31109:SF2 PROTEIN FAM207A RIBOSOME BIOGENESIS PROTEIN SLX9 HOMOLOG HELRO|EnsemblGenome=HelroG195099|UniProtKB=T1FWR0 T1FWR0 20213255 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG163112|UniProtKB=T1ETN8 T1ETN8 20199938 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG64223|UniProtKB=T1FXR5 T1FXR5 20213613 PTHR23349:SF68 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST FI14601P sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG63764|UniProtKB=T1FXK1 T1FXK1 20213549 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED FMRFAMIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG188513|UniProtKB=T1FQ29 T1FQ29 20210926 PTHR12555:SF13 UBIQUITIN FUSION DEGRADATON PROTEIN 1 UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1 protein binding#GO:0005515;binding#GO:0005488;polyubiquitin modification-dependent protein binding#GO:0031593;modification-dependent protein binding#GO:0140030 response to organic substance#GO:0010033;macromolecule catabolic process#GO:0009057;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;response to organonitrogen compound#GO:0010243;ERAD pathway#GO:0036503;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane protein complex#GO:0098796;endoplasmic reticulum protein-containing complex#GO:0140534;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG159718|UniProtKB=T1EPC4 T1EPC4 20198424 PTHR11711:SF41 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1 carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 G-protein#PC00020 Integrin signalling pathway#P00034>Arf1#P00923;Huntington disease#P00029>ARF#P00786 HELRO|EnsemblGenome=HelroG67615|UniProtKB=T1FZ29 T1FZ29 20214077 PTHR11711:SF427 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 G-protein#PC00020 HELRO|EnsemblGenome=HelroG170243|UniProtKB=T1F2T7 T1F2T7 20203136 PTHR11462:SF35 JUN TRANSCRIPTION FACTOR-RELATED TRANSCRIPTION FACTOR JRA sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667 DNA-binding transcription factor#PC00218;basic leucine zipper transcription factor#PC00056 TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>AP-1#P00838 HELRO|EnsemblGenome=HelroG153197|UniProtKB=T1EL07 T1EL07 20197257 PTHR47611:SF3 HAT DIMERISATION DOMAIN, C-TERMINAL HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190136|UniProtKB=T1FRQ2 T1FRQ2 20211499 PTHR11560:SF8 39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN UL10M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;large ribosomal subunit#GO:0015934;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG68265|UniProtKB=T1FZC2 T1FZC2 20214170 PTHR10502:SF239 ANNEXIN ANNEXIN A7 lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488;phosphatidylserine binding#GO:0001786 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;vesicle membrane#GO:0012506;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG81865|UniProtKB=T1G4J8 T1G4J8 20215996 PTHR24033:SF151 EGF-LIKE DOMAIN-CONTAINING PROTEIN NOTCH 2 HELRO|EnsemblGenome=HelroG110111|UniProtKB=T1EEZ2 T1EEZ2 20195144 PTHR11705:SF91 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B FI01817P-RELATED metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metallocarboxypeptidase activity#GO:0004181;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;carboxypeptidase activity#GO:0004180 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG194288|UniProtKB=T1FVW5 T1FVW5 20212961 PTHR23351:SF24 FOS TRANSCRIPTION FACTOR-RELATED ACTIVATING TRANSCRIPTION FACTOR 3-RELATED DNA-binding transcription factor#PC00218;basic leucine zipper transcription factor#PC00056 HELRO|EnsemblGenome=HelroG170016|UniProtKB=T1F2J2 T1F2J2 20203042 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193900|UniProtKB=T1FVG6 T1FVG6 20212812 PTHR23147:SF270 SERINE/ARGININE RICH SPLICING FACTOR RNA-BINDING PROTEIN RNP-1 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;nuclear speck#GO:0016607;organelle#GO:0043226;nuclear body#GO:0016604;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG189038|UniProtKB=T1FQK9 T1FQK9 20211106 PTHR22652:SF0 NUCLEOPORIN NUP43 NUCLEOPORIN NUP43 envelope#GO:0031975;nuclear pore#GO:0005643;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG73351|UniProtKB=T1G1D0 T1G1D0 20214878 PTHR43066:SF1 RHOMBOID-RELATED PROTEIN RHOMBOID PROTEIN 2 hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG172578|UniProtKB=T1F5J7 T1F5J7 20204096 PTHR24393:SF15 ZINC FINGER PROTEIN IP01243P-RELATED DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG158374|UniProtKB=T1EMQ2 T1EMQ2 20197852 PTHR24044:SF417 NOTCH LIGAND FAMILY MEMBER WEARY, ISOFORM B protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG177859|UniProtKB=T1FCD6 T1FCD6 20206485 PTHR20961:SF38 GLYCOSYLTRANSFERASE PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2 transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG190881|UniProtKB=T1FSD9 T1FSD9 20211736 PTHR11216:SF170 EH DOMAIN DYNAMIN ASSOCIATED PROTEIN 160, ISOFORM D localization#GO:0051179;endosomal transport#GO:0016197;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;endocytosis#GO:0006897;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;cellular process#GO:0009987;import into cell#GO:0098657 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG191395|UniProtKB=T1FSY4 T1FSY4 20211931 PTHR24213:SF9 ACTIN-BINDING LIM PROTEIN UNCOORDINATED 115A, ISOFORM B-RELATED cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cell projection organization#GO:0030030;cellular component organization#GO:0016043;plasma membrane bounded cell projection assembly#GO:0120031;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Axon guidance mediated by netrin#P00009>Ablim#P00358 HELRO|EnsemblGenome=HelroG186140|UniProtKB=T1FNQ1 T1FNQ1 20210448 PTHR22762:SF131 ALPHA-GLUCOSIDASE GLYCOSIDE HYDROLASE FAMILY 31 N-TERMINAL DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;glucosidase activity#GO:0015926;hydrolase activity, acting on glycosyl bonds#GO:0016798;alpha-glucosidase activity#GO:0090599;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 glucosidase#PC00108;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG180165|UniProtKB=T1FFJ2 T1FFJ2 20207591 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG193805|UniProtKB=T1FVD5 T1FVD5 20212781 PTHR31002:SF34 SERIPAUPERIN CELL WALL PROTEIN CWP1-RELATED HELRO|EnsemblGenome=HelroG156957|UniProtKB=T1EM41 T1EM41 20197641 PTHR22168:SF8 TMEM26 PROTEIN TRANSMEMBRANE PROTEIN 26 HELRO|EnsemblGenome=HelroG93833|UniProtKB=T1G8X8 T1G8X8 20217525 PTHR10869:SF244 PROLYL 4-HYDROXYLASE ALPHA SUBUNIT PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2 2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;dioxygenase activity#GO:0051213 oxoacid metabolic process#GO:0043436;heterocycle metabolic process#GO:0046483;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular modified amino acid metabolic process#GO:0006575;protein hydroxylation#GO:0018126;alpha-amino acid metabolic process#GO:1901605;protein metabolic process#GO:0019538;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG147243|UniProtKB=T1EJY4 T1EJY4 20196884 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN SI:DKEY-17M8.2 HELRO|EnsemblGenome=HelroG195024|UniProtKB=T1FWN7 T1FWN7 20213232 PTHR47508:SF1 SAM DOMAIN-CONTAINING PROTEIN-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE HELRO|EnsemblGenome=HelroG167527|UniProtKB=T1EZG4 T1EZG4 20201964 PTHR13297:SF9 TBC1 DOMAIN FAMILY MEMBER 23-RELATED ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG70815|UniProtKB=T1G0C6 T1G0C6 20214524 PTHR24208:SF128 LIM/HOMEOBOX PROTEIN LHX LIM3, ISOFORM G sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;neurogenesis#GO:0022008;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;system development#GO:0048731;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;regulation of macromolecule biosynthetic process#GO:0010556;generation of neurons#GO:0048699;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG168577|UniProtKB=T1F0R3 T1F0R3 20202413 PTHR22802:SF456 C-TYPE LECTIN SUPERFAMILY MEMBER FI01427P membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG73062|UniProtKB=T1G194 T1G194 20214842 PTHR24093:SF369 CATION TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE calcium ion transmembrane transporter activity#GO:0015085;inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;P-type ion transporter activity#GO:0015662;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075 intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG189284|UniProtKB=T1FQX1 T1FQX1 20211218 PTHR10909:SF250 ELECTRON TRANSPORT OXIDOREDUCTASE PEROXISOMAL ACYL-COENZYME A OXIDASE 1 nucleotide binding#GO:0000166;fatty acid binding#GO:0005504;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;organic cyclic compound binding#GO:0097159;carboxylic acid binding#GO:0031406;nucleoside phosphate binding#GO:1901265;flavin adenine dinucleotide binding#GO:0050660;heterocyclic compound binding#GO:1901363;lipid binding#GO:0008289;anion binding#GO:0043168;ion binding#GO:0043167;organic acid binding#GO:0043177 oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;lipid oxidation#GO:0034440;cellular metabolic process#GO:0044237;homeostatic process#GO:0042592;lipid catabolic process#GO:0016042;lipid modification#GO:0030258;chemical homeostasis#GO:0048878;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;fatty acid catabolic process#GO:0009062;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;fatty acid metabolic process#GO:0006631;small molecule catabolic process#GO:0044282;fatty acid beta-oxidation#GO:0006635;lipid homeostasis#GO:0055088;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;carboxylic acid metabolic process#GO:0019752;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;microbody#GO:0042579;membrane-bounded organelle#GO:0043227;peroxisome#GO:0005777;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG75631|UniProtKB=T1G279 T1G279 20215177 PTHR23255:SF68 TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II RECEPTOR PROTEIN SERINE_THREONINE KINASE transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to endogenous stimulus#GO:0071495;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;response to growth factor#GO:0070848;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;response to stimulus#GO:0050896;response to endogenous stimulus#GO:0009719;cellular response to growth factor stimulus#GO:0071363;nitrogen compound metabolic process#GO:0006807;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 serine/threonine protein kinase receptor#PC00205 HELRO|EnsemblGenome=HelroG153338|UniProtKB=T1EL42 T1EL42 20197292 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG105203|UniProtKB=T1EDR6 T1EDR6 20194718 PTHR11365:SF2 5-OXOPROLINASE RELATED 5-OXOPROLINASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides#GO:0016812;catalytic activity#GO:0003824 sulfur compound metabolic process#GO:0006790;nitrogen compound metabolic process#GO:0006807;peptide metabolic process#GO:0006518;cellular modified amino acid metabolic process#GO:0006575;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular process#GO:0009987;glutathione metabolic process#GO:0006749;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG177522|UniProtKB=T1FBU3 T1FBU3 20206292 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG164452|UniProtKB=T1EVF4 T1EVF4 20200554 PTHR46077:SF5 E3 UBIQUITIN-PROTEIN LIGASE TOPORS RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein monoubiquitination#GO:0006513;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG193922|UniProtKB=T1FVH3 T1FVH3 20212819 PTHR13544:SF0 SELENOPROTEIN T THIOREDOXIN REDUCTASE-LIKE SELENOPROTEIN T protein-disulfide reductase activity#GO:0015035;disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;antioxidant activity#GO:0016209;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 homeostatic process#GO:0042592;cellular homeostasis#GO:0019725 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG72721|UniProtKB=T1G143 T1G143 20214791 PTHR24247:SF267 5-HYDROXYTRYPTAMINE RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;G protein-coupled amine receptor activity#GO:0008227;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;chemical synaptic transmission#GO:0007268;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;synaptic signaling#GO:0099536;trans-synaptic signaling#GO:0099537;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;cell-cell signaling#GO:0007267;signaling#GO:0023052 somatodendritic compartment#GO:0036477;neuron projection#GO:0043005;dendrite#GO:0030425;cell periphery#GO:0071944;dendritic tree#GO:0097447;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG76604|UniProtKB=T1G2M2 T1G2M2 20215320 PTHR11164:SF0 GLUTAMATE CYSTEINE LIGASE GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT ligase activity#GO:0016874;catalytic activity#GO:0003824 sulfur compound metabolic process#GO:0006790;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;glutathione metabolic process#GO:0006749;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;cellular modified amino acid metabolic process#GO:0006575;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ligase#PC00142;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG66368|UniProtKB=T1FYK3 T1FYK3 20213901 PTHR11972:SF153 NADPH OXIDASE SUPEROXIDE-GENERATING NADPH OXIDASE HEAVY CHAIN SUBUNIT A cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 oxidase#PC00175;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG180445|UniProtKB=T1FFX3 T1FFX3 20207722 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG165479|UniProtKB=T1EWV8 T1EWV8 20201058 PTHR24403:SF67 ZINC FINGER PROTEIN FI01116P-RELATED regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG175217|UniProtKB=T1F911 T1F911 20205310 PTHR10671:SF82 EPITHELIAL MEMBRANE PROTEIN-RELATED GH19567P cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG156388|UniProtKB=T1ELV1 T1ELV1 20197551 PTHR11937:SF274 ACTIN BRAHMA ASSOCIATED PROTEIN 55KD actin and actin related protein#PC00039;cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG192553|UniProtKB=T1FU26 T1FU26 20212322 PTHR24346:SF82 MAP/MICROTUBULE AFFINITY-REGULATING KINASE KP78A-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG175642|UniProtKB=T1F9G5 T1F9G5 20205464 PTHR24416:SF620 TYROSINE-PROTEIN KINASE RECEPTOR TYROSINE-PROTEIN KINASE RECEPTOR TORSO signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG139196|UniProtKB=T1EIY3 T1EIY3 20196533 PTHR11347:SF219 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE, ISOFORM I hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric diester hydrolase activity#GO:0008081;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;cAMP-mediated signaling#GO:0019933;signaling#GO:0023052;cyclic-nucleotide-mediated signaling#GO:0019935 phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG170350|UniProtKB=T1F2Y7 T1F2Y7 20203186 PTHR24243:SF233 G-PROTEIN COUPLED RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG167075|UniProtKB=T1EYZ4 T1EYZ4 20201794 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG111211|UniProtKB=T1EF96 T1EF96 20195248 PTHR23257:SF947 SERINE-THREONINE PROTEIN KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG189893|UniProtKB=T1FRG5 T1FRG5 20211412 PTHR11616:SF321 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;organic acid:sodium symporter activity#GO:0005343;organic acid transmembrane transporter activity#GO:0005342;symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;organic anion transmembrane transporter activity#GO:0008514;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;amino acid:sodium symporter activity#GO:0005283;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;amino acid transmembrane transporter activity#GO:0015171;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;organic anion transport#GO:0015711;amino acid transport#GO:0006865;organic acid transport#GO:0015849;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;nitrogen compound transport#GO:0071705;carboxylic acid transport#GO:0046942;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;amino acid import across plasma membrane#GO:0089718;carboxylic acid transmembrane transport#GO:1905039;localization#GO:0051179;organic substance transport#GO:0071702;import across plasma membrane#GO:0098739;amino acid transmembrane transport#GO:0003333;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transport#GO:0006812;organic acid transmembrane transport#GO:1903825;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>CHT1#P01084 HELRO|EnsemblGenome=HelroG179672|UniProtKB=T1FF05 T1FF05 20207404 PTHR14605:SF1 CHST5 PROTEIN TRANSMEMBRANE PROTEIN 231 cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;regulation of localization#GO:0032879;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of cellular localization#GO:0060341;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;organelle assembly#GO:0070925;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;plasma membrane bounded cell projection assembly#GO:0120031;regulation of protein localization#GO:0032880 bounding membrane of organelle#GO:0098588;ciliary membrane#GO:0060170;membrane-bounded organelle#GO:0043227;plasma membrane region#GO:0098590;organelle membrane#GO:0031090;cell projection membrane#GO:0031253;cell projection#GO:0042995;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;cilium#GO:0005929;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;ciliary transition zone#GO:0035869;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG166696|UniProtKB=T1EYD7 T1EYD7 20201587 PTHR11599:SF6 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT BETA TYPE-2 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;proteasome complex#GO:0000502;membrane-bounded organelle#GO:0043227;endopeptidase complex#GO:1905369;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG179806|UniProtKB=T1FF62 T1FF62 20207461 PTHR31366:SF2 UPF0739 PROTEIN C1ORF74 UPF0739 PROTEIN C1ORF74 HELRO|EnsemblGenome=HelroG165225|UniProtKB=T1EWG5 T1EWG5 20200915 PTHR16021:SF22 MANSC DOMAIN CONTAINING PROTEIN 1 OXIDANT-INDUCED CELL-CYCLE ARREST PROTEIN 5 HELRO|EnsemblGenome=HelroG90535|UniProtKB=T1G7S9 T1G7S9 20217126 PTHR23304:SF183 SPOT2-RELATED T. BRUCEI SPP.-SPECIFIC PROTEIN HELRO|EnsemblGenome=HelroG193892|UniProtKB=T1FVG3 T1FVG3 20212809 PTHR15954:SF4 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG endosomal transport#GO:0016197;localization within membrane#GO:0051668;cellular localization#GO:0051641;vesicle-mediated transport to the plasma membrane#GO:0098876;Golgi organization#GO:0007030;vacuolar transport#GO:0007034;transport#GO:0006810;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;lysosomal transport#GO:0007041;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;endocytic recycling#GO:0032456;establishment of localization#GO:0051234;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle tethering complex#GO:0099023;Golgi apparatus#GO:0005794;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;recycling endosome#GO:0055037;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG63741|UniProtKB=T1FXJ5 T1FXJ5 20213543 PTHR45832:SF8 SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG85916|UniProtKB=T1G643 T1G643 20216540 PTHR11360:SF260 MONOCARBOXYLATE TRANSPORTER MFS DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;monocarboxylic acid transmembrane transporter activity#GO:0008028;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;monocarboxylic acid transport#GO:0015718;establishment of localization#GO:0051234;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942 transporter#PC00227 HELRO|EnsemblGenome=HelroG111080|UniProtKB=T1EF78 T1EF78 20195230 PTHR11562:SF17 CATION EFFLUX PROTEIN/ ZINC TRANSPORTER RE54080P-RELATED inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;transition metal ion transport#GO:0000041;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG127558|UniProtKB=T1EHF4 T1EHF4 20196004 PTHR15710:SF214 E3 UBIQUITIN-PROTEIN LIGASE PRAJA RING-TYPE DOMAIN-CONTAINING PROTEIN ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG68811|UniProtKB=T1FZJ8 T1FZJ8 20214246 PTHR11702:SF31 DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2 GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 HELRO|EnsemblGenome=HelroG186042|UniProtKB=T1FNL1 T1FNL1 20210408 PTHR13615:SF3 GLYCOSYLTRANSFERASE-LIKE 1 GLYCOSYLTRANSFERASE-LIKE DOMAIN-CONTAINING PROTEIN 1 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG124434|UniProtKB=T1EH13 T1EH13 20195863 PTHR43489:SF6 ISOMERASE HYDROXYPYRUVATE ISOMERASE-RELATED isomerase activity#GO:0016853;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;cellular metabolic process#GO:0044237;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281 isomerase#PC00135;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG189278|UniProtKB=T1FQW8 T1FQW8 20211215 PTHR24343:SF540 SERINE/THREONINE KINASE SERINE_THREONINE-PROTEIN KINASE CHK1 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG84539|UniProtKB=T1G5K0 T1G5K0 20216347 PTHR11999:SF70 GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE MIP05841P decarboxylase#PC00089 5-Hydroxytryptamine biosynthesis#P04371>Aromatic L-amino acid decarboxylase#P04400;Dopamine receptor mediated signaling pathway#P05912>DOPA decarb.#P05961;Adrenaline and noradrenaline biosynthesis#P00001>DOPA decarb.#P00066 HELRO|EnsemblGenome=HelroG158869|UniProtKB=T1ENC7 T1ENC7 20198077 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG109211|UniProtKB=T1EER3 T1EER3 20195065 PTHR11216:SF31 EH DOMAIN AT21416P localization#GO:0051179;endosomal transport#GO:0016197;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;endocytosis#GO:0006897;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;cellular process#GO:0009987;import into cell#GO:0098657 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG181315|UniProtKB=T1FGW0 T1FGW0 20208059 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED BRCT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188615|UniProtKB=T1FQ67 T1FQ67 20210964 PTHR24221:SF636 ATP-BINDING CASSETTE SUB-FAMILY B BILE SALT EXPORT PUMP transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 plasma membrane region#GO:0098590;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;apical part of cell#GO:0045177;plasma membrane#GO:0005886;apical plasma membrane#GO:0016324 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG158991|UniProtKB=T1ENG6 T1ENG6 20198116 PTHR11481:SF60 IMMUNOGLOBULIN FC RECEPTOR IG-LIKE DOMAIN-CONTAINING PROTEIN external side of plasma membrane#GO:0009897;cell surface#GO:0009986;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;side of membrane#GO:0098552;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124 HELRO|EnsemblGenome=HelroG63878|UniProtKB=T1FXL7 T1FXL7 20213565 PTHR12465:SF0 UBIQUITIN SPECIFIC PROTEASE HOMOLOG 49 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 20 transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG169961|UniProtKB=T1F2H4 T1F2H4 20203024 PTHR19282:SF544 TETRASPANIN TETRASPANIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG91666|UniProtKB=T1G874 T1G874 20217271 PTHR45771:SF6 HOMEOTIC PROTEIN DEFORMED HOMEOTIC PROTEIN SEX COMBS REDUCED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;pattern specification process#GO:0007389;positive regulation of biological process#GO:0048518;regulation of DNA-templated transcription#GO:0006355;multicellular organism development#GO:0007275;regionalization#GO:0003002;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;anatomical structure development#GO:0048856;biological regulation#GO:0065007;anterior/posterior pattern specification#GO:0009952;multicellular organismal process#GO:0032501;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG75660|UniProtKB=T1G285 T1G285 20215183 PTHR43340:SF1 HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE cation binding#GO:0043169;transferase activity#GO:0016740;magnesium ion binding#GO:0000287;small molecule binding#GO:0036094;glycosyltransferase activity#GO:0016757;binding#GO:0005488;catalytic activity#GO:0003824;metal ion binding#GO:0046872;ion binding#GO:0043167;pentosyltransferase activity#GO:0016763 cellular aromatic compound metabolic process#GO:0006725;purine ribonucleoside monophosphate metabolic process#GO:0009167;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleobase metabolic process#GO:0009112;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;nucleoside monophosphate metabolic process#GO:0009123;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;IMP metabolic process#GO:0046040;heterocycle metabolic process#GO:0046483;purine nucleoside monophosphate metabolic process#GO:0009126;purine nucleobase metabolic process#GO:0006144;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleoside monophosphate metabolic process#GO:0009161;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;IMP biosynthetic process#GO:0006188;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 Adenine and hypoxanthine salvage pathway#P02723>Hypoxanthine phosphoribosyl transferase#P02804;Salvage pyrimidine ribonucleotides#P02775>Uracil phosphoribosyl transferase#P03151;Xanthine and guanine salvage pathway#P02788>Guanine phosphoribosyl transferase#P03245;Xanthine and guanine salvage pathway#P02788>Xanthine phosphoribosyl transferase#P03247 HELRO|EnsemblGenome=HelroG163066|UniProtKB=T1ETM3 T1ETM3 20199923 PTHR13946:SF16 DNA-DIRECTED RNA POLYMERASE I,II,III DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11 catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;RNA polymerase activity#GO:0097747;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;RNA polymerase II activity#GO:0001055 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;RNA polymerase II, core complex#GO:0005665;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase II, holoenzyme#GO:0016591;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG152036|UniProtKB=T1EKN7 T1EKN7 20197137 PTHR24333:SF5 HOMEO BOX HB9 LIKE A-RELATED VENT HOMEOBOX homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG185432|UniProtKB=T1FMT5 T1FMT5 20210134 PTHR11256:SF50 BCL-2 RELATED APOPTOSIS REGULATOR CED-9 protein binding#GO:0005515;binding#GO:0005488 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of cysteine-type endopeptidase activity involved in apoptotic process#GO:0043280;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;signal transduction#GO:0007165;positive regulation of cysteine-type endopeptidase activity#GO:2001056;regulation of protein metabolic process#GO:0051246;apoptotic mitochondrial changes#GO:0008637;regulation of cysteine-type endopeptidase activity#GO:2000116;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;positive regulation of proteolysis#GO:0045862;regulation of biological process#GO:0050789;activation of cysteine-type endopeptidase activity involved in apoptotic process#GO:0006919;DNA damage response#GO:0006974;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;apoptotic process#GO:0006915;cell death#GO:0008219;regulation of hydrolase activity#GO:0051336;mitochondrion organization#GO:0007005;intracellular signal transduction#GO:0035556;positive regulation of biological process#GO:0048518;positive regulation of peptidase activity#GO:0010952;signaling#GO:0023052;regulation of proteolysis#GO:0030162;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;programmed cell death#GO:0012501;cell communication#GO:0007154;cellular component organization#GO:0016043;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of hydrolase activity#GO:0051345;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;intrinsic apoptotic signaling pathway#GO:0097193;apoptotic signaling pathway#GO:0097190;response to stimulus#GO:0050896;positive regulation of protein metabolic process#GO:0051247;response to stress#GO:0006950;extrinsic apoptotic signaling pathway#GO:0097191;regulation of macromolecule metabolic process#GO:0060255;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;regulation of endopeptidase activity#GO:0052548;regulation of cysteine-type endopeptidase activity involved in apoptotic process#GO:0043281;regulation of peptidase activity#GO:0052547;release of cytochrome c from mitochondria#GO:0001836;cellular response to stress#GO:0033554;positive regulation of endopeptidase activity#GO:0010950;regulation of metabolic process#GO:0019222 bounding membrane of organelle#GO:0098588;envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial outer membrane#GO:0005741;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867 HELRO|EnsemblGenome=HelroG121397|UniProtKB=T1EGR8 T1EGR8 20195768 PTHR11675:SF63 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;binding#GO:0005488;catalytic activity#GO:0003824;UDP-glycosyltransferase activity#GO:0008194;protein binding#GO:0005515;catalytic activity, acting on a protein#GO:0140096;signaling receptor binding#GO:0005102;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule modification#GO:0043412;regulation of signaling#GO:0023051;protein modification process#GO:0036211;biosynthetic process#GO:0009058;regulation of Notch signaling pathway#GO:0008593;regulation of biological process#GO:0050789;nitrogen compound metabolic process#GO:0006807;regulation of signal transduction#GO:0009966;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;regulation of cell communication#GO:0010646;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein glycosylation#GO:0006486;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;cellular metabolic process#GO:0044237;organonitrogen compound metabolic process#GO:1901564;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG167455|UniProtKB=T1EZE3 T1EZE3 20201943 PTHR10910:SF62 EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN AT07585P-RELATED nucleic acid binding#GO:0003676;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;adenosine deaminase activity#GO:0004000;RNA binding#GO:0003723;tRNA-specific adenosine deaminase activity#GO:0008251;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;deaminase activity#GO:0019239;double-stranded RNA binding#GO:0003725 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;adenosine to inosine editing#GO:0006382;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG192983|UniProtKB=T1FUH5 T1FUH5 20212471 PTHR12661:SF5 PETER PAN-RELATED SUPPRESSOR OF SWI4 1 HOMOLOG nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159;rRNA binding#GO:0019843 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;organelle assembly#GO:0070925;protein-RNA complex assembly#GO:0022618;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;ribosomal large subunit assembly#GO:0000027;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;protein-RNA complex organization#GO:0071826;non-membrane-bounded organelle assembly#GO:0140694 ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;preribosome, large subunit precursor#GO:0030687;protein-containing complex#GO:0032991 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG69296|UniProtKB=T1FZT0 T1FZT0 20214328 PTHR19269:SF45 TROPOMYOSIN TROPOMYOSIN-1, ISOFORMS 33_34 cytoskeletal protein#PC00085;actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG67767|UniProtKB=T1FZ48 T1FZ48 20214096 PTHR12997:SF2 TYPE I INOSITOL-1,4,5-TRISPHOSPHATE 5-PHOSPHATASE INOSITOL POLYPHOSPHATE-5-PHOSPHATASE A hydrolase activity#GO:0016787;inositol phosphate phosphatase activity#GO:0052745;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 phosphatase#PC00181;hydrolase#PC00121 PI3 kinase pathway#P00048>SHIP#P01200 HELRO|EnsemblGenome=HelroG191237|UniProtKB=T1FSS0 T1FSS0 20211867 PTHR15157:SF5 UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN protein binding#GO:0005515;binding#GO:0005488;SNARE binding#GO:0000149 vesicle fusion#GO:0006906;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;protein-containing complex assembly#GO:0065003;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;membrane fusion#GO:0061025;establishment of localization#GO:0051234;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;vesicle organization#GO:0016050;organelle fusion#GO:0048284 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;vacuole#GO:0005773;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;lytic vacuole#GO:0000323;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG74190|UniProtKB=T1G1N5 T1G1N5 20214983 PTHR46810:SF1 INACTIVE POLYGLYCYLASE TTLL10 INACTIVE POLYGLYCYLASE TTLL10 ligase activity#GO:0016874;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;primary metabolic process#GO:0044238 HELRO|EnsemblGenome=HelroG180087|UniProtKB=T1FFG2 T1FFG2 20207561 PTHR23107:SF34 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN HTH LA-TYPE RNA-BINDING DOMAIN-CONTAINING PROTEIN transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG110638|UniProtKB=T1EF38 T1EF38 20195190 PTHR48207:SF3 SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE transferase activity#GO:0016740;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity#GO:0003824 transferase#PC00220;metabolite interconversion enzyme#PC00262 Coenzyme A linked carnitine metabolism#P02732>L-carnitine dehydratase#P02864;Carnitine metabolism#P02733>Carnitine dehydratase#P02866 HELRO|EnsemblGenome=HelroG163856|UniProtKB=T1EUJ6 T1EUJ6 20200246 PTHR44755:SF8 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide hormone binding#GO:0017046;hormone binding#GO:0042562;binding#GO:0005488;peptide binding#GO:0042277;amide binding#GO:0033218 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG106930|UniProtKB=T1EE60 T1EE60 20194862 PTHR10953:SF102 UBIQUITIN-ACTIVATING ENZYME E1 ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3 thiosulfate sulfurtransferase activity#GO:0004792;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity#GO:0003824;sulfurtransferase activity#GO:0016783;nucleotidyltransferase activity#GO:0016779 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG109389|UniProtKB=T1EET1 T1EET1 20195083 PTHR12100:SF0 SEC10 EXOCYST COMPLEX COMPONENT 5 localization#GO:0051179;localization within membrane#GO:0051668;cellular localization#GO:0051641;vesicle-mediated transport to the plasma membrane#GO:0098876;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;post-Golgi vesicle-mediated transport#GO:0006892;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;Golgi to plasma membrane transport#GO:0006893;export from cell#GO:0140352;secretion by cell#GO:0032940 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;vesicle tethering complex#GO:0099023;exocyst#GO:0000145;cell cortex#GO:0005938;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG169226|UniProtKB=T1F1L5 T1F1L5 20202715 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG188163|UniProtKB=T1FPQ2 T1FPQ2 20210799 PTHR13738:SF1 TROPONIN I TROPONIN I non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG113797|UniProtKB=T1EFW7 T1EFW7 20195469 PTHR32170:SF3 PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4 PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4 peptidase activator activity#GO:0016504;proteasome binding#GO:0070628;molecular function activator activity#GO:0140677;binding#GO:0005488;molecular function regulator activity#GO:0098772;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;peptidase regulator activity#GO:0061134;enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;histone binding#GO:0042393;modification-dependent protein binding#GO:0140030 macromolecule catabolic process#GO:0009057;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;proteolysis#GO:0006508;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;catabolic process#GO:0009056;organonitrogen compound catabolic process#GO:1901565;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG91325|UniProtKB=T1G827 T1G827 20217224 PTHR19850:SF25 GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1 molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591;signaling receptor complex adaptor activity#GO:0030159;protein-macromolecule adaptor activity#GO:0030674 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;plasma membrane protein complex#GO:0098797;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;side of membrane#GO:0098552;cytoplasmic side of plasma membrane#GO:0009898;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;extrinsic component of membrane#GO:0019898 heterotrimeric G-protein#PC00117;G-protein#PC00020 5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;5HT4 type receptor mediated signaling pathway#P04376>G-protein#P04430;Histamine H2 receptor mediated signaling pathway#P04386>G-Protein#P04490;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;Beta1 adrenergic receptor signaling pathway#P04377>G-Protein#P04436;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Gbeta#P00710;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Opioid prodynorphin pathway#P05916>G-protein#P06002;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;Wnt signaling pathway#P00057>GBeta#P01457;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Enkephalin release#P05913>G-Protein (i)#P05974;PI3 kinase pathway#P00048>Gbetagamma#P01188;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Gbeta#P00727;Enkephalin release#P05913>G-Protein (s)#P05977;Opioid proenkephalin pathway#P05915>G-protein#P05994;Beta3 adrenergic receptor signaling pathway#P04379>G-Protein#P04448;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Beta2 adrenergic receptor signaling pathway#P04378>G-Protein#P04443;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Gbeta#P00753 HELRO|EnsemblGenome=HelroG193835|UniProtKB=T1FVE6 T1FVE6 20212792 PTHR13980:SF15 CDC68 RELATED FACT COMPLEX SUBUNIT SPT16 nucleosome binding#GO:0031491;protein-containing complex binding#GO:0044877;binding#GO:0005488;chromatin binding#GO:0003682 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;DNA-templated transcription elongation#GO:0006354;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nucleobase-containing compound biosynthetic process#GO:0034654;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;transcription elongation by RNA polymerase II#GO:0006368;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;transcription elongation factor complex#GO:0008023;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG84246|UniProtKB=T1G5G3 T1G5G3 20216310 PTHR12965:SF0 VACUOLAR PROTEIN SORTING 54 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54 syntaxin binding#GO:0019905;protein binding#GO:0005515;binding#GO:0005488;SNARE binding#GO:0000149 localization#GO:0051179;endosomal transport#GO:0016197;cellular localization#GO:0051641;Golgi to vacuole transport#GO:0006896;establishment of localization#GO:0051234;vacuolar transport#GO:0007034;post-Golgi vesicle-mediated transport#GO:0006892;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;vesicle tethering complex#GO:0099023;Golgi apparatus#GO:0005794;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG106517|UniProtKB=T1EE31 T1EE31 20194833 PTHR17972:SF0 NUCLEOLAR RNA-ASSOCIATED PROTEIN NUCLEOLAR PROTEIN 6 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;macromolecule localization#GO:0033036;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;transport#GO:0006810;RNA processing#GO:0006396;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA localization#GO:0006403;organic substance transport#GO:0071702;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;RNA transport#GO:0050658;ribosome biogenesis#GO:0042254;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;nuclear export#GO:0051168;rRNA metabolic process#GO:0016072;nucleocytoplasmic transport#GO:0006913;nucleobase-containing compound transport#GO:0015931;ribonucleoprotein complex biogenesis#GO:0022613;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405 membrane-enclosed lumen#GO:0031974;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;preribosome#GO:0030684;nuclear protein-containing complex#GO:0140513;90S preribosome#GO:0030686 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG84672|UniProtKB=T1G5L7 T1G5L7 20216364 PTHR11214:SF349 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE BETA-1,3-GALACTOSYLTRANSFERASE BRN transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG163817|UniProtKB=T1EUI3 T1EUI3 20200233 PTHR20835:SF0 E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED E3 UBIQUITIN-PROTEIN LIGASE PPP1R11 phosphatase binding#GO:0019902;phosphatase regulator activity#GO:0019208;binding#GO:0005488;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888;enzyme binding#GO:0019899;protein binding#GO:0005515;phosphatase inhibitor activity#GO:0019212;enzyme inhibitor activity#GO:0004857;protein phosphatase binding#GO:0019903;molecular function inhibitor activity#GO:0140678;protein phosphatase inhibitor activity#GO:0004864;enzyme regulator activity#GO:0030234;protein serine/threonine phosphatase inhibitor activity#GO:0004865 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG66000|UniProtKB=T1FYF9 T1FYF9 20213857 PTHR24115:SF578 KINESIN-RELATED KINESIN-LIKE PROTEIN KIFC1 pyrophosphatase activity#GO:0016462;cytoskeletal protein binding#GO:0008092;microtubule motor activity#GO:0003777;tubulin binding#GO:0015631;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;cytoskeletal motor activity#GO:0003774;microtubule binding#GO:0008017;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;microtubule associated complex#GO:0005875;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG167081|UniProtKB=T1EZ00 T1EZ00 20201800 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG181429|UniProtKB=T1FH01 T1FH01 20208100 PTHR21501:SF1 PROTEIN FAM-161 PROTEIN FAM-161 cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;cellular component organization#GO:0016043;cellular process#GO:0009987;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;organelle organization#GO:0006996 membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cilium#GO:0005929;organelle#GO:0043226 HELRO|EnsemblGenome=HelroG184109|UniProtKB=T1FKL5 T1FKL5 20209364 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG181744|UniProtKB=T1FH99 T1FH99 20208198 PTHR12902:SF1 WASP-1 WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY MEMBER protein kinase A binding#GO:0051018;protein kinase A regulatory subunit binding#GO:0034237;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488 positive regulation of organelle organization#GO:0010638;regulation of organelle organization#GO:0033043;regulation of actin filament organization#GO:0110053;regulation of cellular component organization#GO:0051128;cellular component organization#GO:0016043;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cytoskeleton organization#GO:0051493;actin filament-based process#GO:0030029;regulation of cellular process#GO:0050794;organelle organization#GO:0006996;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;positive regulation of cellular component organization#GO:0051130;cytoskeleton organization#GO:0007010;regulation of actin filament-based process#GO:0032970;actin cytoskeleton organization#GO:0030036;positive regulation of biological process#GO:0048518 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG177605|UniProtKB=T1FBX6 T1FBX6 20206325 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG79532|UniProtKB=T1G3P8 T1G3P8 20215696 PTHR22603:SF66 CHOLINE/ETHANOALAMINE KINASE ETHANOLAMINE KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;glycerophospholipid metabolic process#GO:0006650;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;primary metabolic process#GO:0044238;glycerolipid metabolic process#GO:0046486;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 kinase#PC00137 HELRO|EnsemblGenome=HelroG194538|UniProtKB=T1FW62 T1FW62 20213058 PTHR11134:SF4 ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER AP-4 COMPLEX SUBUNIT BETA-1 localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;cellular process#GO:0009987;transport#GO:0006810 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG172137|UniProtKB=T1F522 T1F522 20203921 PTHR14167:SF76 SH3 DOMAIN-CONTAINING ENDOPHILIN B, ISOFORM A cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cellular process#GO:0009987;membrane organization#GO:0061024 cellular anatomical entity#GO:0110165;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG180133|UniProtKB=T1FFI2 T1FFI2 20207581 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG89821|UniProtKB=T1G7I0 T1G7I0 20217133 PTHR19143:SF444 FIBRINOGEN/TENASCIN/ANGIOPOEITIN PROTEIN SCABROUS external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG187099|UniProtKB=T1FP69 T1FP69 20210616 PTHR22754:SF32 DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED DISCO-INTERACTING PROTEIN 2 HELRO|EnsemblGenome=HelroG194252|UniProtKB=T1FVV2 T1FVV2 20212948 PTHR24179:SF21 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12 MYOSIN BINDING SUBUNIT, ISOFORM O phosphatase regulator activity#GO:0019208;enzyme inhibitor activity#GO:0004857;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG162422|UniProtKB=T1ESM7 T1ESM7 20199577 PTHR19303:SF71 TRANSPOSON ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG82569|UniProtKB=T1G4U0 T1G4U0 20216088 PTHR43718:SF2 LON PROTEASE LON PROTEASE HOMOLOG, MITOCHONDRIAL hydrolase activity#GO:0016787;peptidase activity#GO:0008233;ATP-dependent activity#GO:0140657;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule catabolic process#GO:0009057;protein quality control for misfolded or incompletely synthesized proteins#GO:0006515;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;catabolic process#GO:0009056;organonitrogen compound catabolic process#GO:1901565;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG88241|UniProtKB=T1G705 T1G705 20216852 PTHR13409:SF0 MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L51 LARGE RIBOSOMAL SUBUNIT PROTEIN ML51 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrial large ribosomal subunit#GO:0005762;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;organellar ribosome#GO:0000313;protein-containing complex#GO:0032991;large ribosomal subunit#GO:0015934;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840;mitochondrial protein-containing complex#GO:0098798 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG82366|UniProtKB=T1G4R2 T1G4R2 20216060 PTHR23304:SF183 SPOT2-RELATED T. BRUCEI SPP.-SPECIFIC PROTEIN HELRO|EnsemblGenome=HelroG158017|UniProtKB=T1EMI7 T1EMI7 20197787 PTHR11937:SF47 ACTIN ACTIN-RELATED PROTEIN 6 nucleosome binding#GO:0031491;protein-containing complex binding#GO:0044877;binding#GO:0005488;chromatin binding#GO:0003682 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;INO80-type complex#GO:0097346;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;histone deacetylase complex#GO:0000118;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;Swr1 complex#GO:0000812;nuclear protein-containing complex#GO:0140513 actin and actin related protein#PC00039;cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG189644|UniProtKB=T1FR82 T1FR82 20211329 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG187613|UniProtKB=T1FPB1 T1FPB1 20210658 PTHR12141:SF1 ARFAPTIN-RELATED PRKCA-BINDING PROTEIN enzyme binding#GO:0019899;protein binding#GO:0005515;lipid binding#GO:0008289;protein kinase binding#GO:0019901;phospholipid binding#GO:0005543;binding#GO:0005488;kinase binding#GO:0019900 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;regulation of localization#GO:0032879;regulation of cellular component organization#GO:0051128;establishment of protein localization#GO:0045184;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;organic substance transport#GO:0071702;regulation of cytoskeleton organization#GO:0051493;regulation of transport#GO:0051049;establishment of localization#GO:0051234;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament-based process#GO:0032970;positive regulation of biological process#GO:0048518;localization within membrane#GO:0051668;regulation of endocytosis#GO:0030100;protein localization to membrane#GO:0072657;regulation of organelle organization#GO:0033043;regulation of actin filament organization#GO:0110053;positive regulation of transport#GO:0051050;cellular process#GO:0009987;protein localization#GO:0008104;positive regulation of cellular process#GO:0048522;regulation of supramolecular fiber organization#GO:1902903;localization#GO:0051179;cellular macromolecule localization#GO:0070727;positive regulation of endocytosis#GO:0045807;regulation of cellular process#GO:0050794;protein transport#GO:0015031;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;receptor clustering#GO:0043113;regulation of receptor-mediated endocytosis#GO:0048259 cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;trans-Golgi network membrane#GO:0032588;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;Golgi apparatus subcompartment#GO:0098791;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 vesicle coat protein#PC00235 Ionotropic glutamate receptor pathway#P00037>PICK#P01012 HELRO|EnsemblGenome=HelroG83935|UniProtKB=T1G5C0 T1G5C0 20216267 PTHR23121:SF9 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 transmembrane transporter activity#GO:0022857;sugar transmembrane transporter activity#GO:0051119;transporter activity#GO:0005215;carbohydrate transmembrane transporter activity#GO:0015144 transporter#PC00227 HELRO|EnsemblGenome=HelroG172918|UniProtKB=T1F647 T1F647 20204296 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192125|UniProtKB=T1FTL6 T1FTL6 20212163 PTHR22950:SF652 AMINO ACID TRANSPORTER TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN L-amino acid transmembrane transporter activity#GO:0015179;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;amino acid transport#GO:0006865;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;nitrogen compound transport#GO:0071705;organic acid transmembrane transport#GO:1903825;carboxylic acid transport#GO:0046942;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039 cellular anatomical entity#GO:0110165;membrane#GO:0016020 amino acid transporter#PC00046;transporter#PC00227 HELRO|EnsemblGenome=HelroG158846|UniProtKB=T1ENC0 T1ENC0 20198070 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194477|UniProtKB=T1FW35 T1FW35 20213031 PTHR46100:SF4 IMP2'P USPA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176074|UniProtKB=T1FA41 T1FA41 20205690 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189203|UniProtKB=T1FQS4 T1FQS4 20211171 PTHR24223:SF454 ATP-BINDING CASSETTE SUB-FAMILY C SUBFAMILY NOT NAMED transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG67024|UniProtKB=T1FYV2 T1FYV2 20214000 PTHR11537:SF113 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;delayed rectifier potassium channel activity#GO:0005251;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG83430|UniProtKB=T1G554 T1G554 20216202 PTHR16134:SF119 F-BOX/TPR REPEAT PROTEIN POF3 AT02038P-RELATED ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185695|UniProtKB=T1FN58 T1FN58 20210256 PTHR18952:SF141 CARBONIC ANHYDRASE CARBONIC ANHYDRASE carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG174858|UniProtKB=T1F8J7 T1F8J7 20205146 PTHR42673:SF4 MALEYLACETOACETATE ISOMERASE MALEYLACETOACETATE ISOMERASE glutathione transferase activity#GO:0004364;transferase activity#GO:0016740;isomerase activity#GO:0016853;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;sulfur compound metabolic process#GO:0006790;peptide metabolic process#GO:0006518;organonitrogen compound catabolic process#GO:1901565;glutathione metabolic process#GO:0006749;amino acid catabolic process#GO:0009063;organic cyclic compound metabolic process#GO:1901360;aromatic amino acid metabolic process#GO:0009072;nitrogen compound metabolic process#GO:0006807;cellular modified amino acid metabolic process#GO:0006575;alpha-amino acid metabolic process#GO:1901605;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;amide metabolic process#GO:0043603;L-amino acid metabolic process#GO:0170033;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;aromatic compound catabolic process#GO:0019439;organic cyclic compound catabolic process#GO:1901361;aromatic amino acid family catabolic process#GO:0009074;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281 isomerase#PC00135;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG163374|UniProtKB=T1ETZ1 T1ETZ1 20200041 PTHR33604:SF3 OSJNBA0004B13.7 PROTEIN OSJNBA0004B13.7 PROTEIN HELRO|EnsemblGenome=HelroG96459|UniProtKB=T1G9C2 T1G9C2 20217669 PTHR23049:SF34 MYOSIN REGULATORY LIGHT CHAIN 2 MYOSIN REGULATORY LIGHT POLYPEPTIDE 9 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG95781|UniProtKB=T1G975 T1G975 20217622 PTHR48182:SF2 PROTEIN SERAC1 PROTEIN SERAC1 HELRO|EnsemblGenome=HelroG163153|UniProtKB=T1ETQ6 T1ETQ6 20199956 PTHR24034:SF89 EGF-LIKE DOMAIN-CONTAINING PROTEIN COMPLEMENT COMPONENT C1Q RECEPTOR extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG193502|UniProtKB=T1FV23 T1FV23 20212669 PTHR12447:SF31 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13 LD31969P cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG193441|UniProtKB=T1FUZ5 T1FUZ5 20212641 PTHR22883:SF301 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC12 palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular localization#GO:0051641;macromolecule localization#GO:0033036;macromolecule modification#GO:0043412;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;protein palmitoylation#GO:0018345;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;localization within membrane#GO:0051668;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein localization to membrane#GO:0072657;organonitrogen compound biosynthetic process#GO:1901566;protein targeting#GO:0006605;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;protein acylation#GO:0043543;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipoprotein biosynthetic process#GO:0042158;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;lipoprotein metabolic process#GO:0042157 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG158511|UniProtKB=T1EMV9 T1EMV9 20197909 PTHR43250:SF2 EXODEOXYRIBONUCLEASE III EXODEOXYRIBONUCLEASE III HELRO|EnsemblGenome=HelroG68072|UniProtKB=T1FZ99 T1FZ99 20214147 PTHR11523:SF28 SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT NA_K-ATPASE BETA SUBUNIT ISOFORM 4-RELATED molecular function activator activity#GO:0140677;ATPase activator activity#GO:0001671;molecular function regulator activity#GO:0098772 inorganic ion homeostasis#GO:0098771;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;sodium ion homeostasis#GO:0055078;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;import into cell#GO:0098657;monoatomic cation transmembrane transport#GO:0098655;export from cell#GO:0140352;sodium ion transmembrane transport#GO:0035725;potassium ion import across plasma membrane#GO:1990573;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG78362|UniProtKB=T1G3B0 T1G3B0 20215558 PTHR45659:SF4 HOMEOBOX PROTEIN HOX HOMEOBOX PROTEIN ABDOMINAL-A sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regionalization#GO:0003002;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;anterior/posterior pattern specification#GO:0009952;multicellular organismal process#GO:0032501;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;pattern specification process#GO:0007389;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG176999|UniProtKB=T1FB43 T1FB43 20206042 PTHR11311:SF30 SPONDIN SPONDIN-LIKE TSP1 DOMAIN-CONTAINING PROTEIN cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;organelle organization#GO:0006996 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG180170|UniProtKB=T1FFJ5 T1FFJ5 20207594 PTHR12323:SF0 SR-RELATED CTD ASSOCIATED FACTOR 6 CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;chemical homeostasis#GO:0048878;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;monoatomic ion homeostasis#GO:0050801 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;perinuclear region of cytoplasm#GO:0048471;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG141821|UniProtKB=T1EJ43 T1EJ43 20196593 PTHR11003:SF334 POTASSIUM CHANNEL, SUBFAMILY K FI03418P monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG156856|UniProtKB=T1EM19 T1EM19 20197619 PTHR23065:SF11 PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1 SYNDAPIN, ISOFORM C lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488 regulation of endocytosis#GO:0030100;membrane organization#GO:0061024;plasma membrane organization#GO:0007009;endomembrane system organization#GO:0010256;regulation of localization#GO:0032879;regulation of cellular component organization#GO:0051128;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of transport#GO:0051049;regulation of cellular process#GO:0050794;organelle organization#GO:0006996;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG182038|UniProtKB=T1FHM7 T1FHM7 20208326 PTHR11132:SF255 SOLUTE CARRIER FAMILY 35 GDP-FUCOSE TRANSPORTER 1 secondary active transmembrane transporter activity#GO:0015291;antiporter activity#GO:0015297;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG181828|UniProtKB=T1FHD8 T1FHD8 20208237 PTHR24216:SF65 PAXILLIN-RELATED PAXILLIN-LIKE PROTEIN 1 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG172475|UniProtKB=T1F5D3 T1F5D3 20204032 PTHR46685:SF1 28S RIBOSOMAL PROTEIN S15, MITOCHONDRIAL SMALL RIBOSOMAL SUBUNIT PROTEIN US15M structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;mitochondrial gene expression#GO:0140053;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;mitochondrial translation#GO:0032543;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;organellar ribosome#GO:0000313;protein-containing complex#GO:0032991;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;small ribosomal subunit#GO:0015935;ribosome#GO:0005840;mitochondrial small ribosomal subunit#GO:0005763;mitochondrial protein-containing complex#GO:0098798 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG113439|UniProtKB=T1EFS4 T1EFS4 20195426 PTHR45783:SF3 KINESIN LIGHT CHAIN KINESIN LIGHT CHAIN kinesin binding#GO:0019894;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;binding#GO:0005488 microtubule-based movement#GO:0007018;cellular process#GO:0009987;microtubule-based process#GO:0007017 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 Alzheimer disease-amyloid secretase pathway#P00003>kinesin#P00107 HELRO|EnsemblGenome=HelroG92151|UniProtKB=T1G8C4 T1G8C4 20217321 PTHR31690:SF4 FUCOSE MUTAROTASE FUCOSE MUTAROTASE racemase and epimerase activity, acting on carbohydrates and derivatives#GO:0016857;carbohydrate binding#GO:0030246;isomerase activity#GO:0016853;small molecule binding#GO:0036094;monosaccharide binding#GO:0048029;binding#GO:0005488;catalytic activity#GO:0003824 monosaccharide metabolic process#GO:0005996;hexose metabolic process#GO:0019318;carbohydrate metabolic process#GO:0005975;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;glycosylation#GO:0070085;organic substance metabolic process#GO:0071704 HELRO|EnsemblGenome=HelroG97475|UniProtKB=T1G9G9 T1G9G9 20217716 PTHR23003:SF62 RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN SERINE_ARGININE (SR)-TYPE SHUTTLING MRNA BINDING PROTEIN NPL3 nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG164806|UniProtKB=T1EVU1 T1EVU1 20200691 PTHR10454:SF210 CASPASE CASPASE-2 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG77555|UniProtKB=T1G2Z7 T1G2Z7 20215445 PTHR22883:SF40 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular localization#GO:0051641;macromolecule localization#GO:0033036;macromolecule modification#GO:0043412;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;protein palmitoylation#GO:0018345;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;localization within membrane#GO:0051668;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein localization to membrane#GO:0072657;organonitrogen compound biosynthetic process#GO:1901566;protein targeting#GO:0006605;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;protein acylation#GO:0043543;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipoprotein biosynthetic process#GO:0042158;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;lipoprotein metabolic process#GO:0042157 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG81778|UniProtKB=T1G4I6 T1G4I6 20215984 PTHR23314:SF0 SPERM-ASSOCIATED ANTIGEN 6 ARMADILLO REPEAT-CONTAINING SPERM-ASSOCIATED ANTIGEN 6 cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 microtubule-based movement#GO:0007018;cellular process#GO:0009987;microtubule-based process#GO:0007017;cilium movement#GO:0003341 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG102264|UniProtKB=T1ED90 T1ED90 20194542 PTHR12933:SF0 ORF PROTEIN-RELATED U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG snoRNA binding#GO:0030515;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;rRNA binding#GO:0019843;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG103014|UniProtKB=T1EDD8 T1EDD8 20194590 PTHR23511:SF34 SYNAPTIC VESICLE GLYCOPROTEIN 2 SYNAPTIC VESICLE GLYCOPROTEIN 2 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG109399|UniProtKB=T1EET3 T1EET3 20195085 PTHR13856:SF137 VHS DOMAIN CONTAINING PROTEIN FAMILY GH05942P protein binding#GO:0005515;clathrin binding#GO:0030276;binding#GO:0005488 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG182947|UniProtKB=T1FIY7 T1FIY7 20208786 PTHR23236:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC INITIATION FACTOR 4B-RELATED single-stranded RNA binding#GO:0003727;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;poly(A) binding#GO:0008143;binding#GO:0005488;organic cyclic compound binding#GO:0097159 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG191278|UniProtKB=T1FSU2 T1FSU2 20211889 PTHR15128:SF0 TAL1 SCL INTERRUPTING LOCUS SCL-INTERRUPTING LOCUS PROTEIN cellular localization#GO:0051641;signal transduction#GO:0007165;mitotic spindle organization#GO:0007052;macromolecule localization#GO:0033036;smoothened signaling pathway#GO:0007224;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;microtubule cytoskeleton organization involved in mitosis#GO:1902850;mitotic cell cycle process#GO:1903047;regulation of biological process#GO:0050789;mitotic cell cycle#GO:0000278;cytoskeleton organization#GO:0007010;spindle organization#GO:0007051;protein localization to organelle#GO:0033365;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular component organization#GO:0016043;cell communication#GO:0007154;cellular process#GO:0009987;microtubule organizing center organization#GO:0031023;protein localization#GO:0008104;localization#GO:0051179;response to stimulus#GO:0050896;protein localization to cytoskeleton#GO:0044380;cellular component organization or biogenesis#GO:0071840;cellular macromolecule localization#GO:0070727;microtubule-based process#GO:0007017;regulation of cellular process#GO:0050794;organelle organization#GO:0006996;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;cell cycle#GO:0007049 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG79470|UniProtKB=T1G3P1 T1G3P1 20215689 PTHR11071:SF561 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;catalytic activity#GO:0003824;peptide binding#GO:0042277;amide binding#GO:0033218 macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein peptidyl-prolyl isomerization#GO:0000413;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG186007|UniProtKB=T1FNJ6 T1FNJ6 20210393 PTHR13273:SF14 ANAMORSIN ANAMORSIN cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;iron-sulfur cluster assembly#GO:0016226;cellular component organization#GO:0016043;cellular process#GO:0009987 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG194757|UniProtKB=T1FWD5 T1FWD5 20213130 PTHR12479:SF10 LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN bounding membrane of organelle#GO:0098588;lytic vacuole membrane#GO:0098852;intracellular membrane-bounded organelle#GO:0043231;vacuolar membrane#GO:0005774;vacuole#GO:0005773;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;lytic vacuole#GO:0000323;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;lysosomal membrane#GO:0005765;lysosome#GO:0005764;membrane-bounded organelle#GO:0043227 transporter#PC00227 HELRO|EnsemblGenome=HelroG192903|UniProtKB=T1FUE7 T1FUE7 20212443 PTHR33604:SF3 OSJNBA0004B13.7 PROTEIN OSJNBA0004B13.7 PROTEIN HELRO|EnsemblGenome=HelroG163780|UniProtKB=T1EUG7 T1EUG7 20200217 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG80045|UniProtKB=T1G3X0 T1G3X0 20215768 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;chloride transmembrane transporter activity#GO:0015108;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;inorganic anion transmembrane transport#GO:0098661;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic anion transport#GO:0006820;chloride transport#GO:0006821;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;inorganic anion transport#GO:0015698 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG72621|UniProtKB=T1G127 T1G127 20214775 PTHR11956:SF5 ARGINYL-TRNA SYNTHETASE ARGININE--TRNA LIGASE, CYTOPLASMIC catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG185339|UniProtKB=T1FMP4 T1FMP4 20210093 PTHR13806:SF46 FLOTILLIN-RELATED FLOTILLIN-1-RELATED enzyme binding#GO:0019899;protein binding#GO:0005515;protease binding#GO:0002020;binding#GO:0005488 localization#GO:0051179;protein localization to plasma membrane#GO:0072659;protein localization to cell periphery#GO:1990778;localization within membrane#GO:0051668;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;cellular process#GO:0009987;protein localization#GO:0008104 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG175493|UniProtKB=T1F9B8 T1F9B8 20205417 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG99809|UniProtKB=T1G9V3 T1G9V3 20217849 PTHR11485:SF29 TRANSFERRIN TRANSFERRIN 2 localization#GO:0051179;metal ion transport#GO:0030001;establishment of localization#GO:0051234;transport#GO:0006810;monoatomic cation transport#GO:0006812;iron ion transport#GO:0006826;transition metal ion transport#GO:0000041;monoatomic ion transport#GO:0006811 endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;extracellular region#GO:0005576;early endosome#GO:0005769;cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;recycling endosome#GO:0055037;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;plasma membrane#GO:0005886 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG167262|UniProtKB=T1EZ68 T1EZ68 20201868 PTHR45740:SF2 POLY [ADP-RIBOSE] POLYMERASE POLY [ADP-RIBOSE] POLYMERASE transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;pentosyltransferase activity#GO:0016763 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG70741|UniProtKB=T1G0B5 T1G0B5 20214513 PTHR19411:SF0 PROTEIN BUD31-RELATED PROTEIN BUD31 HOMOLOG cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG189291|UniProtKB=T1FQX4 T1FQX4 20211221 PTHR19282:SF534 TETRASPANIN TETRASPANIN FAMILY-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG164129|UniProtKB=T1EUZ3 T1EUZ3 20200393 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG183954|UniProtKB=T1FKC5 T1FKC5 20209274 PTHR19890:SF10 FIBROBLAST GROWTH FACTOR RECEPTOR FIBROBLAST GROWTH FACTOR RECEPTOR-LIKE 1 transmembrane signal receptor#PC00197;tyrosine protein kinase receptor#PC00233 HELRO|EnsemblGenome=HelroG179281|UniProtKB=T1FEH2 T1FEH2 20207221 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77501|UniProtKB=T1G2Y7 T1G2Y7 20215435 PTHR13023:SF3 APYRASE SOLUBLE CALCIUM-ACTIVATED NUCLEOTIDASE 1 pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;nucleoside diphosphate phosphatase activity#GO:0017110;catalytic activity#GO:0003824 glycoprotein biosynthetic process#GO:0009101;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;proteoglycan metabolic process#GO:0006029;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;proteoglycan biosynthetic process#GO:0030166;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 nucleotide phosphatase#PC00173;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG186048|UniProtKB=T1FNL4 T1FNL4 20210411 PTHR23138:SF94 RAN BINDING PROTEIN RAN BINDING PROTEIN 1 nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 envelope#GO:0031975;cytoplasm#GO:0005737;nuclear pore#GO:0005643;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG178638|UniProtKB=T1FDH4 T1FDH4 20206873 PTHR13015:SF0 PROTEIN AD-016-RELATED WASH COMPLEX SUBUNIT 3 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;transport#GO:0006810;protein-containing complex assembly#GO:0065003;vesicle-mediated transport#GO:0016192;actin polymerization or depolymerization#GO:0008154;actin filament polymerization#GO:0030041;cellular component organization#GO:0016043;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;protein polymerization#GO:0051258;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;export from cell#GO:0140352;secretion by cell#GO:0032940 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG186233|UniProtKB=T1FNU7 T1FNU7 20210494 PTHR10104:SF1 STATHMIN STATHMIN, ISOFORM D cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 regulation of microtubule-based process#GO:0032886;neurogenesis#GO:0022008;cell projection organization#GO:0030030;microtubule depolymerization#GO:0007019;developmental process#GO:0032502;microtubule cytoskeleton organization#GO:0000226;regulation of cellular component organization#GO:0051128;nervous system development#GO:0007399;microtubule polymerization or depolymerization#GO:0031109;plasma membrane bounded cell projection organization#GO:0120036;regulation of biological process#GO:0050789;system development#GO:0048731;cell differentiation#GO:0030154;regulation of cytoskeleton organization#GO:0051493;cellular component disassembly#GO:0022411;supramolecular fiber organization#GO:0097435;regulation of microtubule cytoskeleton organization#GO:0070507;neuron differentiation#GO:0030182;cytoskeleton organization#GO:0007010;cellular developmental process#GO:0048869;protein-containing complex disassembly#GO:0032984;regulation of organelle organization#GO:0033043;multicellular organism development#GO:0007275;cellular component organization#GO:0016043;protein depolymerization#GO:0051261;regulation of microtubule polymerization or depolymerization#GO:0031110;cellular process#GO:0009987;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;microtubule-based process#GO:0007017;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;protein-containing complex organization#GO:0043933;anatomical structure development#GO:0048856;biological regulation#GO:0065007;neuron development#GO:0048666;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 cytoplasm#GO:0005737;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;neuron projection#GO:0043005;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG167167|UniProtKB=T1EZ33 T1EZ33 20201833 PTHR13260:SF0 ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4 ANAPHASE-PROMOTING COMPLEX SUBUNIT 4 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;anaphase-promoting complex-dependent catabolic process#GO:0031145;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein K11-linked ubiquitination#GO:0070979;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;anaphase-promoting complex#GO:0005680;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;nuclear periphery#GO:0034399;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG84990|UniProtKB=T1G5R2 T1G5R2 20216409 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG79413|UniProtKB=T1G3N6 T1G3N6 20215684 PTHR45810:SF9 HISTONE H3.2 HISTONE H3 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG169120|UniProtKB=T1F1F6 T1F1F6 20202656 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157153|UniProtKB=T1EM71 T1EM71 20197671 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;heme binding#GO:0020037 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG87481|UniProtKB=T1G6Q8 T1G6Q8 20216755 PTHR11742:SF6 MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE IA-RELATED hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 carbohydrate derivative metabolic process#GO:1901135;macromolecule modification#GO:0043412;protein catabolic process#GO:0030163;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;macromolecule catabolic process#GO:0009057;response to endoplasmic reticulum stress#GO:0034976;response to oxygen-containing compound#GO:1901700;macromolecule metabolic process#GO:0043170;carbohydrate derivative catabolic process#GO:1901136;organonitrogen compound metabolic process#GO:1901564;ERAD pathway#GO:0036503;response to organonitrogen compound#GO:0010243;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;cellular response to stress#GO:0033554 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG183130|UniProtKB=T1FJ62 T1FJ62 20208861 PTHR14312:SF6 CREB/ATF BZIP TRANSCRIPTION FACTOR SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG157739|UniProtKB=T1EMF1 T1EMF1 20197751 PTHR11918:SF45 RADICAL SAM PROTEINS THREONYLCARBAMOYLADENOSINE TRNA METHYLTHIOTRANSFERASE transferase activity#GO:0016740;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;tRNA metabolic process#GO:0006399;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG163574|UniProtKB=T1EU83 T1EU83 20200133 PTHR46077:SF5 E3 UBIQUITIN-PROTEIN LIGASE TOPORS RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein monoubiquitination#GO:0006513;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG89219|UniProtKB=T1G7A5 T1G7A5 20216952 PTHR19300:SF57 BETA-1,4-GALACTOSYLTRANSFERASE BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE galactosyltransferase activity#GO:0008378;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycosylation#GO:0070085;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG141954|UniProtKB=T1EJ46 T1EJ46 20196596 PTHR23119:SF51 DISCS LARGE DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN enzyme binding#GO:0019899;protein binding#GO:0005515;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900 establishment or maintenance of cell polarity#GO:0007163;localization within membrane#GO:0051668;cellular localization#GO:0051641;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;developmental process#GO:0032502;multicellular organism development#GO:0007275;cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987;protein localization#GO:0008104;localization#GO:0051179;embryo development#GO:0009790;cellular macromolecule localization#GO:0070727;anatomical structure development#GO:0048856;establishment or maintenance of apical/basal cell polarity#GO:0035088;multicellular organismal process#GO:0032501;receptor clustering#GO:0043113;establishment or maintenance of bipolar cell polarity#GO:0061245;protein-containing complex localization#GO:0031503 basal plasma membrane#GO:0009925;basolateral plasma membrane#GO:0016323;cell junction#GO:0030054;plasma membrane region#GO:0098590;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;basal part of cell#GO:0045178;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG166093|UniProtKB=T1EXR1 T1EXR1 20201361 PTHR24023:SF1066 COLLAGEN ALPHA FIBRILLAR COLLAGEN NC1 DOMAIN-CONTAINING PROTEIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG64364|UniProtKB=T1FXT5 T1FXT5 20213633 PTHR10827:SF85 RETICULOCALBIN CALCIUM-BINDING PROTEIN calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG99365|UniProtKB=T1G9S3 T1G9S3 20217819 PTHR24302:SF15 CYTOCHROME P450 FAMILY 3 FATTY-ACID PEROXYGENASE oxygenase#PC00177;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG163501|UniProtKB=T1EU50 T1EU50 20200100 PTHR22932:SF1 TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE CO-CHAPERONE PROTEIN DAF-41 heat shock protein binding#GO:0031072;protein binding#GO:0005515;protein-folding chaperone binding#GO:0051087;binding#GO:0005488;Hsp90 protein binding#GO:0051879 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein-containing complex assembly#GO:0065003;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;chaperone-mediated protein complex assembly#GO:0051131;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;protein folding#GO:0006457;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG64117|UniProtKB=T1FXP7 T1FXP7 20213595 PTHR21016:SF4 BETA-AMYLOID BINDING PROTEIN-RELATED TM2 DOMAIN-CONTAINING PROTEIN 2 HELRO|EnsemblGenome=HelroG111587|UniProtKB=T1EFC7 T1EFC7 20195279 PTHR24072:SF100 RHO FAMILY GTPASE RHO-RELATED GTP-BINDING PROTEIN RHOC GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;enzyme binding#GO:0019899;ribonucleoside triphosphate phosphatase activity#GO:0017111;kinase binding#GO:0019900;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817;protein kinase binding#GO:0019901;anion binding#GO:0043168;ion binding#GO:0043167 regulation of biological process#GO:0050789;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;regulation of organelle organization#GO:0033043;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;regulation of actin filament-based process#GO:0032970;regulation of cellular component organization#GO:0051128 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 small GTPase#PC00208 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Rho#P00860;Axon guidance mediated by semaphorins#P00007>Rho#P00341;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>RhoA#P05938;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RhoA#P00740;Ras Pathway#P04393>Rho#P04578;Integrin signalling pathway#P00034>Rho#P00948;Angiogenesis#P00005>GTPase#P00254;Axon guidance mediated by Slit/Robo#P00008>Rho#P00355;Cytoskeletal regulation by Rho GTPase#P00016>Rho#P00507 HELRO|EnsemblGenome=HelroG111641|UniProtKB=T1EFD2 T1EFD2 20195284 PTHR22808:SF3 NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING 5-METHYLCYTOSINE RRNA METHYLTRANSFERASE NSUN4 methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA modification#GO:0009451;rRNA modification#GO:0000154;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;ribosome biogenesis#GO:0042254;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;rRNA methylation#GO:0031167;nucleic acid metabolic process#GO:0090304;methylation#GO:0032259;macromolecule methylation#GO:0043414;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;RNA methylation#GO:0001510 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrial large ribosomal subunit#GO:0005762;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;organellar ribosome#GO:0000313;protein-containing complex#GO:0032991;large ribosomal subunit#GO:0015934;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840;mitochondrial protein-containing complex#GO:0098798 RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG191089|UniProtKB=T1FSK9 T1FSK9 20211806 PTHR10083:SF373 KUNITZ-TYPE PROTEASE INHIBITOR-RELATED SERINE PEPTIDASE INHIBITOR, KUNITZ TYPE, 2 peptidase inhibitor activity#GO:0030414;molecular function regulator activity#GO:0098772;serine-type endopeptidase inhibitor activity#GO:0004867;peptidase regulator activity#GO:0061134;enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;endopeptidase regulator activity#GO:0061135;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG102324|UniProtKB=T1ED95 T1ED95 20194547 PTHR12655:SF0 ACYL-COA THIOESTERASE ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;fatty acyl-CoA hydrolase activity#GO:0047617;catalytic activity#GO:0003824;thiolester hydrolase activity#GO:0016790 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;carbohydrate derivative metabolic process#GO:1901135;sulfur compound metabolic process#GO:0006790;acyl-CoA metabolic process#GO:0006637;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;amide metabolic process#GO:0043603;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;nucleobase-containing small molecule metabolic process#GO:0055086 esterase#PC00097 HELRO|EnsemblGenome=HelroG155003|UniProtKB=T1ELG9 T1ELG9 20197419 PTHR12701:SF20 BCR-ASSOCIATED PROTEIN, BAP ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;protein localization to endoplasmic reticulum#GO:0070972;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;protein localization to organelle#GO:0033365;intracellular transport#GO:0046907;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;protein localization#GO:0008104 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG70246|UniProtKB=T1G038 T1G038 20214436 PTHR10155:SF16 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT SUPPRESSOR OF CYTOKINE SIGNALING 2 enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;phosphatidylinositol 3-kinase complex#GO:0005942;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;membrane#GO:0016020;transferase complex, transferring phosphorus-containing groups#GO:0061695;extrinsic component of membrane#GO:0019898 kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG180047|UniProtKB=T1FFE2 T1FFE2 20207541 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG169025|UniProtKB=T1F199 T1F199 20202599 PTHR14732:SF0 RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG172679|UniProtKB=T1F5S0 T1F5S0 20204169 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cell communication#GO:0007154;cellular process#GO:0009987;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;Notch signaling pathway#GO:0007219 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG93491|UniProtKB=T1G8W0 T1G8W0 20217507 PTHR43766:SF1 TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG149347|UniProtKB=T1EKC8 T1EKC8 20197028 PTHR11347:SF198 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 2 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric diester hydrolase activity#GO:0008081;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;cAMP-mediated signaling#GO:0019933;signaling#GO:0023052;cyclic-nucleotide-mediated signaling#GO:0019935 phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG71264|UniProtKB=T1G0I5 T1G0I5 20214583 PTHR12733:SF3 MITOCHONDRIAL ATP SYNTHASE B CHAIN ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG162502|UniProtKB=T1ESR4 T1ESR4 20199614 PTHR19327:SF0 GOLGIN GOLGIN SUBFAMILY A MEMBER 4 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG180276|UniProtKB=T1FFN8 T1FFN8 20207637 PTHR10671:SF82 EPITHELIAL MEMBRANE PROTEIN-RELATED GH19567P cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG151014|UniProtKB=T1EKI2 T1EKI2 20197082 PTHR35365:SF13 LP04239P SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG178132|UniProtKB=T1FCT2 T1FCT2 20206631 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG169468|UniProtKB=T1F1Z4 T1F1Z4 20202844 PTHR11266:SF17 PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17 PROTEIN MPV17 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG68344|UniProtKB=T1FZD4 T1FZD4 20214182 PTHR10738:SF0 PROTEIN ARGININE N-METHYLTRANSFERASE 5 PROTEIN ARGININE N-METHYLTRANSFERASE 5 N-methyltransferase activity#GO:0008170;histone modifying activity#GO:0140993;transferase activity#GO:0016740;catalytic activity#GO:0003824;histone methyltransferase activity#GO:0042054;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a protein#GO:0140096;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein methyltransferase activity#GO:0008276 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG101627|UniProtKB=T1ED60 T1ED60 20194512 PTHR20938:SF0 INTEGRATOR COMPLEX SUBUNIT 4 INTEGRATOR COMPLEX SUBUNIT 4 HELRO|EnsemblGenome=HelroG179256|UniProtKB=T1FEF8 T1FEF8 20207207 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164299|UniProtKB=T1EV85 T1EV85 20200485 PTHR13143:SF6 TETRATRICOPEPTIDE REPEAT PROTEIN 19 TETRATRICOPEPTIDE REPEAT PROTEIN 19, MITOCHONDRIAL cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrial respiratory chain complex III assembly#GO:0034551;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;cytochrome complex assembly#GO:0017004;protein-containing complex assembly#GO:0065003;mitochondrion organization#GO:0007005;cellular component organization#GO:0016043;cellular process#GO:0009987 envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG185069|UniProtKB=T1FMC9 T1FMC9 20209978 PTHR10891:SF918 EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN CALCIUM-BINDING PROTEIN 2 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG88521|UniProtKB=T1G736 T1G736 20216883 PTHR12544:SF29 GLUTAMINASE GLUTAMINASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824 dicarboxylic acid metabolic process#GO:0043648;proteinogenic amino acid biosynthetic process#GO:0170038;organonitrogen compound catabolic process#GO:1901565;biosynthetic process#GO:0009058;carboxylic acid biosynthetic process#GO:0046394;amino acid catabolic process#GO:0009063;nitrogen compound metabolic process#GO:0006807;glutamate metabolic process#GO:0006536;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;L-amino acid metabolic process#GO:0170033;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248;organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;alpha-amino acid biosynthetic process#GO:1901607;L-amino acid biosynthetic process#GO:0170034;small molecule biosynthetic process#GO:0044283;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG177005|UniProtKB=T1FB46 T1FB46 20206045 PTHR22906:SF43 PROPERDIN PROPERDIN HELRO|EnsemblGenome=HelroG173283|UniProtKB=T1F6M8 T1F6M8 20204477 PTHR24410:SF23 HL07962P-RELATED BTB DOMAIN-CONTAINING PROTEIN-RELATED defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG180689|UniProtKB=T1FG62 T1FG62 20207811 PTHR31395:SF26 SHISA STANLEY-CUP scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG189097|UniProtKB=T1FQM9 T1FQM9 20211126 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG161627|UniProtKB=T1ERQ4 T1ERQ4 20199254 PTHR11086:SF18 DEOXYCYTIDYLATE DEAMINASE-RELATED DEOXYCYTIDYLATE DEAMINASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;deaminase activity#GO:0019239;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;nucleoside metabolic process#GO:0009116;glycosyl compound catabolic process#GO:1901658;carbohydrate derivative metabolic process#GO:1901135;heterocycle catabolic process#GO:0046700;pyrimidine-containing compound metabolic process#GO:0072527;organonitrogen compound catabolic process#GO:1901565;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;nucleoside catabolic process#GO:0009164;organic substance catabolic process#GO:1901575;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248;heterocycle metabolic process#GO:0046483;carbohydrate derivative catabolic process#GO:1901136;cellular metabolic process#GO:0044237;organonitrogen compound metabolic process#GO:1901564;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;small molecule catabolic process#GO:0044282;aromatic compound catabolic process#GO:0019439;nucleobase-containing small molecule catabolic process#GO:0034656;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;glycosyl compound metabolic process#GO:1901657;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 deaminase#PC00088;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG98251|UniProtKB=T1G9L4 T1G9L4 20217760 PTHR11893:SF36 INNEXIN INNEXIN-5 cell junction protein#PC00070;gap junction#PC00105 HELRO|EnsemblGenome=HelroG65033|UniProtKB=T1FY24 T1FY24 20213722 PTHR10887:SF341 DNA2/NAM7 HELICASE FAMILY NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1 negative regulation of gene expression#GO:0010629;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular metabolic process#GO:0031324;protein-DNA complex organization#GO:0071824;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;heterochromatin formation#GO:0031507;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;negative regulation of gene expression, epigenetic#GO:0045814;cellular process#GO:0009987;epigenetic regulation of gene expression#GO:0040029;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;heterochromatin organization#GO:0070828;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG67859|UniProtKB=T1FZ64 T1FZ64 20214112 PTHR46273:SF4 MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED AT19640P signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG189072|UniProtKB=T1FQM2 T1FQM2 20211119 PTHR45924:SF2 FI17866P1 FI17866P1 nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;binding#GO:0005488;enzyme binding#GO:0019899;protein binding#GO:0005515;small GTPase binding#GO:0031267;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 HELRO|EnsemblGenome=HelroG189273|UniProtKB=T1FQW6 T1FQW6 20211213 PTHR32142:SF55 B BOX-TYPE DOMAIN-CONTAINING PROTEIN-RELATED ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG76315|UniProtKB=T1G2I2 T1G2I2 20215280 PTHR18952:SF208 CARBONIC ANHYDRASE CARBONIC ANHYDRASE XA-RELATED carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 cellular metabolic process#GO:0044237;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG194200|UniProtKB=T1FVS7 T1FVS7 20212923 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG80894|UniProtKB=T1G469 T1G469 20215867 PTHR45956:SF6 RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN RUN DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG76875|UniProtKB=T1G2Q4 T1G2Q4 20215352 PTHR11003:SF335 POTASSIUM CHANNEL, SUBFAMILY K POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG185971|UniProtKB=T1FNI0 T1FNI0 20210377 PTHR45671:SF10 SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED SOLUTE CARRIER FAMILY 25 MEMBER 3 secondary active transmembrane transporter activity#GO:0015291;inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215 localization#GO:0051179;inorganic anion transmembrane transport#GO:0098661;phosphate ion transport#GO:0006817;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;inorganic anion transport#GO:0015698 envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;organelle inner membrane#GO:0019866;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227 mitochondrial carrier protein#PC00158;secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG150771|UniProtKB=T1EKH3 T1EKH3 20197073 PTHR42999:SF1 ANTIBIOTIC RESISTANCE PROTEIN MCBG PENTAPEPTIDE REPEAT-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG66187|UniProtKB=T1FYI3 T1FYI3 20213881 PTHR24346:SF82 MAP/MICROTUBULE AFFINITY-REGULATING KINASE KP78A-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG183321|UniProtKB=T1FJG3 T1FJG3 20208962 PTHR21847:SF1 EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 10 EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 10 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG62642|UniProtKB=T1FX30 T1FX30 20213378 PTHR12932:SF9 P25 ALPHA-RELATED TUBULIN POLYMERIZATION-PROMOTING PROTEIN HOMOLOG cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;microtubule cytoskeleton organization#GO:0000226;protein-containing complex assembly#GO:0065003;regulation of cellular component organization#GO:0051128;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule polymerization or depolymerization#GO:0031109;positive regulation of protein polymerization#GO:0032273;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of protein-containing complex assembly#GO:0043254;microtubule polymerization#GO:0046785;microtubule-based process#GO:0007017;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;protein-containing complex organization#GO:0043933;supramolecular fiber organization#GO:0097435;microtubule bundle formation#GO:0001578;biological regulation#GO:0065007;protein polymerization#GO:0051258;positive regulation of cellular component organization#GO:0051130;cytoskeleton organization#GO:0007010;positive regulation of cellular component biogenesis#GO:0044089;regulation of protein polymerization#GO:0032271;positive regulation of biological process#GO:0048518 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG90190|UniProtKB=T1G7M1 T1G7M1 20217068 PTHR12277:SF81 ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN PROTEIN ABHD13 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG163185|UniProtKB=T1ETS0 T1ETS0 20199970 PTHR11960:SF8 EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED nucleic acid binding#GO:0003676;RNA binding#GO:0003723;translation regulator activity#GO:0045182;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation initiation factor activity#GO:0003743;RNA cap binding#GO:0000339;translation regulator activity, nucleic acid binding#GO:0090079;translation factor activity, RNA binding#GO:0008135 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;translational initiation#GO:0006413;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG95849|UniProtKB=T1G984 T1G984 20217631 PTHR11309:SF99 FRIZZLED FRIZZLED-4 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;protein binding#GO:0005515;Wnt-protein binding#GO:0017147;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;non-canonical Wnt signaling pathway#GO:0035567;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;cell-cell signaling by wnt#GO:0198738;canonical Wnt signaling pathway#GO:0060070;cell-cell signaling#GO:0007267;signaling#GO:0023052;Wnt signaling pathway#GO:0016055 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;extracellular space#GO:0005615;membrane#GO:0016020;extracellular region#GO:0005576;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Wnt signaling pathway#P00057>Frizzled#P01428;Cadherin signaling pathway#P00012>Frizzled#P00475 HELRO|EnsemblGenome=HelroG160256|UniProtKB=T1EQ11 T1EQ11 20198661 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG86506|UniProtKB=T1G6D3 T1G6D3 20216630 PTHR10619:SF0 F-ACTIN-CAPPING PROTEIN SUBUNIT BETA F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2 cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 negative regulation of protein polymerization#GO:0032272;negative regulation of protein depolymerization#GO:1901880;negative regulation of biological process#GO:0048519;negative regulation of actin filament depolymerization#GO:0030835;developmental process#GO:0032502;regulation of cellular component organization#GO:0051128;regulation of actin polymerization or depolymerization#GO:0008064;regulation of biological process#GO:0050789;regulation of cytoskeleton organization#GO:0051493;regulation of protein-containing complex assembly#GO:0043254;regulation of biological quality#GO:0065008;anatomical structure morphogenesis#GO:0009653;regulation of cellular component biogenesis#GO:0044087;negative regulation of organelle organization#GO:0010639;negative regulation of protein-containing complex disassembly#GO:0043242;regulation of actin cytoskeleton organization#GO:0032956;barbed-end actin filament capping#GO:0051016;regulation of actin filament-based process#GO:0032970;negative regulation of cellular component organization#GO:0051129;regulation of protein polymerization#GO:0032271;negative regulation of cellular process#GO:0048523;regulation of anatomical structure size#GO:0090066;regulation of actin filament length#GO:0030832;regulation of organelle organization#GO:0033043;regulation of actin filament organization#GO:0110053;regulation of protein-containing complex disassembly#GO:0043244;cellular component organization#GO:0016043;cell morphogenesis#GO:0000902;cellular process#GO:0009987;regulation of actin filament polymerization#GO:0030833;regulation of cellular component size#GO:0032535;negative regulation of supramolecular fiber organization#GO:1902904;regulation of supramolecular fiber organization#GO:1902903;cellular component organization or biogenesis#GO:0071840;regulation of protein depolymerization#GO:1901879;regulation of actin filament depolymerization#GO:0030834;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;negative regulation of actin filament polymerization#GO:0030837;biological regulation#GO:0065007;negative regulation of protein-containing complex assembly#GO:0031333;negative regulation of cytoskeleton organization#GO:0051494 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG174354|UniProtKB=T1F816 T1F816 20204965 PTHR22948:SF29 TUDOR DOMAIN CONTAINING PROTEIN FI02030P-RELATED scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG163701|UniProtKB=T1EUD3 T1EUD3 20200183 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168163|UniProtKB=T1F091 T1F091 20202241 PTHR44472:SF1 DDB1- AND CUL4-ASSOCIATED FACTOR 4-RELATED DDB1 AND CUL4 ASSOCIATED FACTOR 4 HELRO|EnsemblGenome=HelroG182835|UniProtKB=T1FIU2 T1FIU2 20208741 PTHR11567:SF211 ACID PHOSPHATASE-RELATED PROSTATIC ACID PHOSPHATASE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 cellular metabolic process#GO:0044237;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;dephosphorylation#GO:0016311;metabolic process#GO:0008152 metabolite interconversion enzyme#PC00262;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG164455|UniProtKB=T1EVF7 T1EVF7 20200557 PTHR46077:SF5 E3 UBIQUITIN-PROTEIN LIGASE TOPORS RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein monoubiquitination#GO:0006513;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG155580|UniProtKB=T1ELJ1 T1ELJ1 20197441 PTHR11278:SF0 40S RIBOSOMAL PROTEIN S7 SMALL RIBOSOMAL SUBUNIT PROTEIN ES7 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 small-subunit processome#GO:0032040;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;preribosome#GO:0030684;small ribosomal subunit#GO:0015935;ribosome#GO:0005840;90S preribosome#GO:0030686 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG178978|UniProtKB=T1FE00 T1FE00 20207049 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG99764|UniProtKB=T1G9V1 T1G9V1 20217847 PTHR32465:SF0 BARDET-BIEDL SYNDROME 2 PROTEIN BARDET-BIEDL SYNDROME 2 PROTEIN organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 microtubule organizing center#GO:0005815;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;motile cilium#GO:0031514;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cytoskeleton#GO:0005856;BBSome#GO:0034464;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG185752|UniProtKB=T1FN89 T1FN89 20210287 PTHR18968:SF166 THIAMINE PYROPHOSPHATE ENZYMES 2-HYDROXYACYL-COA LYASE 2 nucleotide binding#GO:0000166;transferase activity#GO:0016740;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;flavin adenine dinucleotide binding#GO:0050660;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;branched-chain amino acid metabolic process#GO:0009081;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;branched-chain amino acid biosynthetic process#GO:0009082;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;alpha-amino acid biosynthetic process#GO:1901607;nitrogen compound metabolic process#GO:0006807;alpha-amino acid metabolic process#GO:1901605;small molecule biosynthetic process#GO:0044283;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 Isoleucine biosynthesis#P02748>Acetolactate synthase#P02997;Valine biosynthesis#P02785>Acetolactate synthase#P03216 HELRO|EnsemblGenome=HelroG159163|UniProtKB=T1ENP3 T1ENP3 20198193 PTHR12232:SF0 SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN THIOREDOXIN DOMAIN-CONTAINING PROTEIN cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG182498|UniProtKB=T1FIA0 T1FIA0 20208549 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG76915|UniProtKB=T1G2R1 T1G2R1 20215359 PTHR13522:SF3 U6 SNRNA PHOSPHODIESTERASE 1 U6 SNRNA PHOSPHODIESTERASE 1 catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;catalytic activity#GO:0003824;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;3'-5'-RNA exonuclease activity#GO:0000175;exonuclease activity#GO:0004527;3'-5' exonuclease activity#GO:0008408;RNA nuclease activity#GO:0004540 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;snRNA metabolic process#GO:0016073;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;snRNA 3'-end processing#GO:0034472;snRNA processing#GO:0016180;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG79842|UniProtKB=T1G3U2 T1G3U2 20215740 PTHR24320:SF226 RETINOL DEHYDROGENASE RETINOL DEHYDROGENASE 11 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG164546|UniProtKB=T1EVK3 T1EVK3 20200603 PTHR23167:SF82 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG146610|UniProtKB=T1EJT4 T1EJT4 20196834 PTHR31305:SF2 SNARE-ASSOCIATED PROTEIN SNAPIN SNARE-ASSOCIATED PROTEIN SNAPIN protein binding#GO:0005515;SNARE binding#GO:0000149;binding#GO:0005488 lysosome organization#GO:0007040;cellular localization#GO:0051641;synaptic vesicle cycle#GO:0099504;organelle localization#GO:0051640;transport#GO:0006810;regulation of signaling#GO:0023051;regulation of secretion by cell#GO:1903530;regulation of localization#GO:0032879;endosome to lysosome transport#GO:0008333;regulation of neurotransmitter secretion#GO:0046928;lysosomal transport#GO:0007041;regulation of vesicle-mediated transport#GO:0060627;regulated exocytosis#GO:0045055;lysosome localization#GO:0032418;regulation of biological process#GO:0050789;vacuole organization#GO:0007033;regulation of transport#GO:0051049;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;regulation of secretion#GO:0051046;secretion#GO:0046903;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;signal release#GO:0023061;cell-cell signaling#GO:0007267;signaling#GO:0023052;synaptic vesicle exocytosis#GO:0016079;regulation of exocytosis#GO:0017157;secretion by cell#GO:0032940;neurotransmitter secretion#GO:0007269;regulation of cell communication#GO:0010646;vacuolar transport#GO:0007034;trans-synaptic signaling#GO:0099537;vesicle-mediated transport#GO:0016192;cell communication#GO:0007154;cellular component organization#GO:0016043;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;signal release from synapse#GO:0099643;exocytosis#GO:0006887;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;lytic vacuole organization#GO:0080171;export from cell#GO:0140352;vesicle-mediated transport in synapse#GO:0099003 presynapse#GO:0098793;synapse#GO:0045202;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;synaptic vesicle#GO:0008021;cell junction#GO:0030054;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;transport vesicle#GO:0030133;secretory vesicle#GO:0099503 HELRO|EnsemblGenome=HelroG175770|UniProtKB=T1F9M8 T1F9M8 20205527 PTHR18843:SF7 TORSIN-1A-INTERACTING PROTEIN LAMINA-ASSOCIATED POLYPEPTIDE 1B ISOFORM 1-RELATED cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cellular process#GO:0009987;membrane organization#GO:0061024 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG169948|UniProtKB=T1F2G8 T1F2G8 20203018 PTHR11347:SF226 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE DUAL SPECIFICITY CALCIUM_CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric diester hydrolase activity#GO:0008081;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;cAMP-mediated signaling#GO:0019933;signaling#GO:0023052;cyclic-nucleotide-mediated signaling#GO:0019935 phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG184011|UniProtKB=T1FKF2 T1FKF2 20209301 PTHR36191:SF10 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG188581|UniProtKB=T1FQ54 T1FQ54 20210951 PTHR16196:SF0 CELL CYCLE CONTROL PROTEIN CWF25 PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;U2-type spliceosomal complex#GO:0005684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG176860|UniProtKB=T1FAZ7 T1FAZ7 20205996 PTHR10438:SF468 THIOREDOXIN THIOREDOXIN-1-RELATED oxidoreductase#PC00176 Oxidative stress response#P00046>TRX#P01122;Hypoxia response via HIF activation#P00030>Thioredoxin#P00825 HELRO|EnsemblGenome=HelroG156500|UniProtKB=T1ELX7 T1ELX7 20197577 PTHR20994:SF0 ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6 ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;macroautophagy#GO:0016236;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;organelle assembly#GO:0070925;process utilizing autophagic mechanism#GO:0061919;cellular component organization or biogenesis#GO:0071840;vacuole organization#GO:0007033;organelle organization#GO:0006996;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;autophagosome assembly#GO:0000045;catabolic process#GO:0009056;protein metabolic process#GO:0019538;autophagy#GO:0006914;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248 membrane protein complex#GO:0098796;endoplasmic reticulum protein-containing complex#GO:0140534;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;EMC complex#GO:0072546;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG80560|UniProtKB=T1G421 T1G421 20215819 PTHR43416:SF5 DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL transferase activity#GO:0016740;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 aerobic respiration#GO:0009060;cellular respiration#GO:0045333;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;cellular process#GO:0009987;tricarboxylic acid cycle#GO:0006099;energy derivation by oxidation of organic compounds#GO:0015980;primary metabolic process#GO:0044238;metabolic process#GO:0008152 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG169042|UniProtKB=T1F1A9 T1F1A9 20202609 PTHR11304:SF29 EPHRIN EPHRIN protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 neuron projection guidance#GO:0097485;signal transduction#GO:0007165;neurogenesis#GO:0022008;cell projection organization#GO:0030030;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;regulation of biological process#GO:0050789;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;axonogenesis#GO:0007409;plasma membrane bounded cell projection morphogenesis#GO:0120039;signaling#GO:0023052;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;multicellular organism development#GO:0007275;cell morphogenesis#GO:0000902;cellular component organization#GO:0016043;cell communication#GO:0007154;cellular process#GO:0009987;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;neuron projection development#GO:0031175;axon development#GO:0061564;enzyme-linked receptor protein signaling pathway#GO:0007167;cell morphogenesis involved in neuron differentiation#GO:0048667;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 membrane-bound signaling molecule#PC00152;intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG169073|UniProtKB=T1F1D2 T1F1D2 20202632 PTHR24161:SF85 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED PALMITOYLTRANSFERASE HIP14 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG89250|UniProtKB=T1G7B0 T1G7B0 20216957 PTHR31204:SF1 SIGMA INTRACELLULAR RECEPTOR 2 SIGMA INTRACELLULAR RECEPTOR 2 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG173299|UniProtKB=T1F6N4 T1F6N4 20204483 PTHR34203:SF15 METHYLTRANSFERASE, FKBM FAMILY PROTEIN SLL1173 PROTEIN methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG171697|UniProtKB=T1F4K4 T1F4K4 20203753 PTHR46205:SF3 LOQUACIOUS, ISOFORM B LOQUACIOUS, ISOFORM B HELRO|EnsemblGenome=HelroG177236|UniProtKB=T1FBE0 T1FBE0 20206139 PTHR46273:SF4 MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED AT19640P signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG164302|UniProtKB=T1EV86 T1EV86 20200486 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178909|UniProtKB=T1FDV9 T1FDV9 20207008 PTHR13546:SF15 RE60986P CCDC85 HELRO|EnsemblGenome=HelroG156412|UniProtKB=T1ELV7 T1ELV7 20197557 PTHR10971:SF5 MRNA EXPORT FACTOR AND BUB3 MITOTIC CHECKPOINT PROTEIN BUB3 protein binding#GO:0005515;ubiquitin-like protein binding#GO:0032182;binding#GO:0005488;ubiquitin binding#GO:0043130 negative regulation of sister chromatid segregation#GO:0033046;negative regulation of mitotic sister chromatid separation#GO:2000816;negative regulation of biological process#GO:0048519;regulation of mitotic nuclear division#GO:0007088;signal transduction#GO:0007165;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;regulation of chromosome segregation#GO:0051983;mitotic cell cycle checkpoint signaling#GO:0007093;negative regulation of chromosome organization#GO:2001251;regulation of chromosome separation#GO:1905818;negative regulation of mitotic nuclear division#GO:0045839;cell cycle process#GO:0022402;regulation of cellular component organization#GO:0051128;negative regulation of cell cycle process#GO:0010948;negative regulation of nuclear division#GO:0051784;negative regulation of mitotic sister chromatid segregation#GO:0033048;mitotic cell cycle process#GO:1903047;regulation of biological process#GO:0050789;cell cycle checkpoint signaling#GO:0000075;negative regulation of mitotic cell cycle phase transition#GO:1901991;mitotic cell cycle#GO:0000278;negative regulation of organelle organization#GO:0010639;regulation of mitotic sister chromatid segregation#GO:0033047;intracellular signal transduction#GO:0035556;negative regulation of cellular component organization#GO:0051129;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;regulation of chromosome organization#GO:0033044;cellular response to stimulus#GO:0051716;regulation of mitotic sister chromatid separation#GO:0010965;regulation of nuclear division#GO:0051783;regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of cell cycle#GO:0045786;regulation of organelle organization#GO:0033043;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;mitotic spindle assembly checkpoint signaling#GO:0007094;negative regulation of chromosome segregation#GO:0051985;regulation of cell cycle phase transition#GO:1901987;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of mitotic cell cycle#GO:0045930;cell communication#GO:0007154;cellular process#GO:0009987;regulation of mitotic metaphase/anaphase transition#GO:0030071;regulation of cell cycle process#GO:0010564;response to stimulus#GO:0050896;negative regulation of chromosome separation#GO:1905819;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of sister chromatid segregation#GO:0033045;regulation of mitotic cell cycle#GO:0007346;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100 membrane-enclosed lumen#GO:0031974;supramolecular complex#GO:0099080;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;kinetochore#GO:0000776;nucleoplasm#GO:0005654;condensed chromosome, centromeric region#GO:0000779;condensed chromosome#GO:0000793;intracellular organelle lumen#GO:0070013;chromosome, centromeric region#GO:0000775;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;chromosomal region#GO:0098687;nuclear lumen#GO:0031981 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG185762|UniProtKB=T1FN93 T1FN93 20210291 PTHR11893:SF36 INNEXIN INNEXIN-5 cell junction protein#PC00070;gap junction#PC00105 HELRO|EnsemblGenome=HelroG194512|UniProtKB=T1FW50 T1FW50 20213046 PTHR18966:SF593 IONOTROPIC GLUTAMATE RECEPTOR IONOTROPIC GLUTAMATE RECEPTOR C-TERMINAL DOMAIN-CONTAINING PROTEIN transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;transporter activity#GO:0005215;transmembrane signaling receptor activity#GO:0004888;glutamate receptor activity#GO:0008066;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 regulation of cell communication#GO:0010646;regulation of signaling#GO:0023051;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission#GO:0007268;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;synaptic signaling#GO:0099536;biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177;synaptic transmission, glutamatergic#GO:0035249;signaling#GO:0023052;cell-cell signaling#GO:0007267 synapse#GO:0045202;postsynaptic specialization#GO:0099572;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;neuron to neuron synapse#GO:0098984;membrane#GO:0016020;synaptic membrane#GO:0097060;asymmetric synapse#GO:0032279;postsynaptic specialization membrane#GO:0099634;postsynaptic density membrane#GO:0098839;plasma membrane region#GO:0098590;postsynapse#GO:0098794;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG188309|UniProtKB=T1FPV0 T1FPV0 20210847 PTHR12879:SF8 SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2 SPHINGOLIPID DELTA(4)-DESATURASE DES1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 lipid metabolic process#GO:0006629;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;membrane lipid biosynthetic process#GO:0046467;sphingolipid metabolic process#GO:0006665;ceramide metabolic process#GO:0006672;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;membrane lipid metabolic process#GO:0006643;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;ceramide biosynthetic process#GO:0046513;cellular lipid metabolic process#GO:0044255;amide metabolic process#GO:0043603;sphingolipid biosynthetic process#GO:0030148;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 hydroxylase#PC00122 HELRO|EnsemblGenome=HelroG62983|UniProtKB=T1FX89 T1FX89 20213437 PTHR23030:SF39 PCD6 INTERACTING PROTEIN-RELATED PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN endosomal transport#GO:0016197;cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;protein catabolic process#GO:0030163;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;nitrogen compound transport#GO:0071705;organonitrogen compound catabolic process#GO:1901565;late endosome to vacuole transport#GO:0045324;protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043328;establishment of protein localization#GO:0045184;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;modification-dependent macromolecule catabolic process#GO:0043632;organic substance transport#GO:0071702;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein localization to organelle#GO:0033365;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;establishment of protein localization to vacuole#GO:0072666;modification-dependent protein catabolic process#GO:0019941;vacuolar transport#GO:0007034;macromolecule metabolic process#GO:0043170;protein localization to vacuole#GO:0072665;organonitrogen compound metabolic process#GO:1901564;establishment of protein localization to organelle#GO:0072594;vesicle-mediated transport#GO:0016192;multivesicular body sorting pathway#GO:0071985;cellular process#GO:0009987;protein localization#GO:0008104;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;localization#GO:0051179;cellular macromolecule localization#GO:0070727;protein transport#GO:0015031;endosome transport via multivesicular body sorting pathway#GO:0032509;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG170469|UniProtKB=T1F337 T1F337 20203236 PTHR19290:SF167 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED PROTEIN DIMMED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;neurogenesis#GO:0022008;positive regulation of RNA biosynthetic process#GO:1902680;cell projection organization#GO:0030030;regulation of nitrogen compound metabolic process#GO:0051171;animal organ development#GO:0048513;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;regulation of biological process#GO:0050789;system development#GO:0048731;cell differentiation#GO:0030154;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;neuron differentiation#GO:0030182;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;multicellular organism development#GO:0007275;cellular component organization#GO:0016043;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;anatomical structure development#GO:0048856;biological regulation#GO:0065007;neuron development#GO:0048666;multicellular organismal process#GO:0032501;positive regulation of RNA metabolic process#GO:0051254;generation of neurons#GO:0048699;sensory organ development#GO:0007423;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG165183|UniProtKB=T1EWE3 T1EWE3 20200893 PTHR33091:SF29 PROTEIN, PUTATIVE, EXPRESSED-RELATED SUBTILISIN INHIBITOR 1 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG174682|UniProtKB=T1F8D2 T1F8D2 20205081 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG169361|UniProtKB=T1F1U4 T1F1U4 20202794 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG127438|UniProtKB=T1EHE7 T1EHE7 20195997 PTHR12441:SF10 ATP SYNTHASE COUPLING FACTOR 6, MITOCHONDRIAL ATP SYNTHASE-COUPLING FACTOR 6, MITOCHONDRIAL envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;ATPase complex#GO:1904949;organelle inner membrane#GO:0019866;mitochondrial proton-transporting ATP synthase complex#GO:0005753;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;proton-transporting two-sector ATPase complex#GO:0016469;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;proton-transporting ATP synthase complex#GO:0045259;mitochondrial protein-containing complex#GO:0098798 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG94228|UniProtKB=T1G8Z5 T1G8Z5 20217542 PTHR24221:SF503 ATP-BINDING CASSETTE SUB-FAMILY B MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG176363|UniProtKB=T1FAG2 T1FAG2 20205811 PTHR46512:SF9 PEPTIDYLPROLYL ISOMERASE PEPTIDYLPROLYL ISOMERASE chaperone#PC00072 HELRO|EnsemblGenome=HelroG194088|UniProtKB=T1FVN6 T1FVN6 20212882 PTHR12436:SF38 80 KDA MCM3-ASSOCIATED PROTEIN SAC3 DOMAIN-CONTAINING PROTEIN 1 cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;nucleic acid transport#GO:0050657;centrosome cycle#GO:0007098;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;centrosome duplication#GO:0051298;biosynthetic process#GO:0009058;chromosome segregation#GO:0007059;RNA localization#GO:0006403;organic substance transport#GO:0071702;establishment of localization#GO:0051234;RNA transport#GO:0050658;spindle assembly#GO:0051225;cytoskeleton organization#GO:0007010;spindle organization#GO:0007051;non-membrane-bounded organelle assembly#GO:0140694;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;mRNA export from nucleus#GO:0006406;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;mRNA transport#GO:0051028;cellular process#GO:0009987;microtubule organizing center organization#GO:0031023;localization#GO:0051179;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;nuclear export#GO:0051168;organelle organization#GO:0006996;nucleocytoplasmic transport#GO:0006913;nucleobase-containing compound transport#GO:0015931;cell cycle#GO:0007049;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405 microtubule organizing center#GO:0005815;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;centrosome#GO:0005813;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;transcription export complex 2#GO:0070390;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;nuclear protein-containing complex#GO:0140513;spindle#GO:0005819 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG183528|UniProtKB=T1FJS8 T1FJS8 20209077 PTHR24238:SF75 G-PROTEIN COUPLED RECEPTOR CHOLECYSTOKININ-LIKE RECEPTOR AT 17D1-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;neuropeptide signaling pathway#GO:0007218;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG169924|UniProtKB=T1F2G3 T1F2G3 20203013 PTHR44324:SF4 WD40 REPEAT DOMAIN 95 WD40 REPEAT DOMAIN 95 HELRO|EnsemblGenome=HelroG185803|UniProtKB=T1FNB2 T1FNB2 20210309 PTHR11349:SF91 NUCLEOSIDE DIPHOSPHATE KINASE NUCLEOSIDE DIPHOSPHATE KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;nucleoside diphosphate kinase activity#GO:0004550;phosphotransferase activity, phosphate group as acceptor#GO:0016776;catalytic activity#GO:0003824;kinase activity#GO:0016301 transferase#PC00220;kinase#PC00137;metabolite interconversion enzyme#PC00262 De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dTDP kinase#P02919;De novo pyrimidine ribonucleotides biosythesis#P02740>CDP kinase#P02929;De novo pyrimidine ribonucleotides biosythesis#P02740>UDP kinase#P02923;De novo purine biosynthesis#P02738>GDP kinase#P02891;De novo purine biosynthesis#P02738>dADP kinase#P02907;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dCDP kinase#P02914;De novo purine biosynthesis#P02738>dGDP kinase#P02889;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dUDP kinase#P02912 HELRO|EnsemblGenome=HelroG144967|UniProtKB=T1EJH5 T1EJH5 20196881 PTHR11467:SF36 HISTONE H1 HISTONE 24-RELATED nucleosome binding#GO:0031491;nucleic acid binding#GO:0003676;chromatin DNA binding#GO:0031490;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;protein-containing complex binding#GO:0044877 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA metabolic process#GO:0051052;chromosome condensation#GO:0030261;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;cellular process#GO:0009987;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;regulation of macromolecule metabolic process#GO:0060255;organelle organization#GO:0006996;chromosome organization#GO:0051276;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA recombination#GO:0045910;negative regulation of DNA metabolic process#GO:0051053;regulation of DNA recombination#GO:0000018;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG180021|UniProtKB=T1FFC9 T1FFC9 20207528 PTHR24248:SF129 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG189729|UniProtKB=T1FRA9 T1FRA9 20211356 PTHR23320:SF165 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MARVEL DOMAIN-CONTAINING PROTEIN transporter#PC00227 HELRO|EnsemblGenome=HelroG176915|UniProtKB=T1FB16 T1FB16 20206015 PTHR34929:SF1 ZGC:153157 INAF MOTIF CONTAINING 2 HELRO|EnsemblGenome=HelroG194400|UniProtKB=T1FW08 T1FW08 20213004 PTHR13060:SF0 SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2 PROTEIN ECDYSONELESS HOMOLOG membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG105974|UniProtKB=T1EDY9 T1EDY9 20194791 PTHR47958:SF32 ATP-DEPENDENT RNA HELICASE DBP3 RNA HELICASE nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG75376|UniProtKB=T1G242 T1G242 20215140 PTHR46491:SF3 CDGSH IRON SULFUR DOMAIN PROTEIN HOMOLOG CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL small molecule binding#GO:0036094;iron-sulfur cluster binding#GO:0051536;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG177130|UniProtKB=T1FB93 T1FB93 20206092 PTHR15069:SF1 PROTEASOME ASSEMBLY CHAPERONE 1 PROTEASOME ASSEMBLY CHAPERONE 1 proteasome binding#GO:0070628;protein-containing complex binding#GO:0044877;binding#GO:0005488 protein-containing complex assembly#GO:0065003;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cellular process#GO:0009987;protein-containing complex organization#GO:0043933 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG173706|UniProtKB=T1F752 T1F752 20204651 PTHR18952:SF141 CARBONIC ANHYDRASE CARBONIC ANHYDRASE carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG97828|UniProtKB=T1G9J2 T1G9J2 PTHR37412:SF2 C2 DOMAIN-CONTAINING PROTEIN 5 C2 DOMAIN-CONTAINING PROTEIN 5 cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;lipid binding#GO:0008289;ion binding#GO:0043167;phospholipid binding#GO:0005543 cellular localization#GO:0051641;intracellular protein transmembrane transport#GO:0065002;positive regulation of organelle organization#GO:0010638;macromolecule localization#GO:0033036;transport#GO:0006810;protein transmembrane transport#GO:0071806;nitrogen compound transport#GO:0071705;regulation of localization#GO:0032879;regulation of cellular component organization#GO:0051128;establishment of protein localization#GO:0045184;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;organic substance transport#GO:0071702;regulation of transport#GO:0051049;establishment of localization#GO:0051234;positive regulation of biological process#GO:0048518;regulation of protein localization#GO:0032880;protein localization to plasma membrane#GO:0072659;localization within membrane#GO:0051668;regulation of transmembrane transport#GO:0034762;positive regulation of establishment of protein localization#GO:1904951;transmembrane transport#GO:0055085;protein localization to membrane#GO:0072657;regulation of protein localization to membrane#GO:1905475;regulation of organelle organization#GO:0033043;positive regulation of transport#GO:0051050;regulation of cellular localization#GO:0060341;cellular process#GO:0009987;protein localization#GO:0008104;positive regulation of cellular process#GO:0048522;localization#GO:0051179;protein localization to cell periphery#GO:1990778;cellular macromolecule localization#GO:0070727;regulation of cellular process#GO:0050794;protein transport#GO:0015031;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;positive regulation of protein localization#GO:1903829;regulation of establishment of protein localization#GO:0070201 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG171297|UniProtKB=T1F418 T1F418 20203567 PTHR15698:SF10 PROTEIN CBG15099 PHYTANOYL-COA HYDROXYLASE-INTERACTING PROTEIN-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180275|UniProtKB=T1FFN7 T1FFN7 20207636 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185893|UniProtKB=T1FNE6 T1FNE6 20210343 PTHR12109:SF3 RING FINGER PROTEIN 141-RELATED RING FINGER PROTEIN 141 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG167077|UniProtKB=T1EYZ6 T1EYZ6 20201796 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG87285|UniProtKB=T1G6N6 T1G6N6 20216733 PTHR24200:SF11 TOUCAN, ISOFORM A TOUCAN, ISOFORM A HELRO|EnsemblGenome=HelroG82406|UniProtKB=T1G4R9 T1G4R9 20216067 PTHR12225:SF0 ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN PROTEASOMAL UBIQUITIN RECEPTOR ADRM1 peptidase activator activity#GO:0016504;proteasome binding#GO:0070628;molecular function activator activity#GO:0140677;binding#GO:0005488;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047;peptidase regulator activity#GO:0061134;protein-containing complex binding#GO:0044877;endopeptidase regulator activity#GO:0061135;enzyme regulator activity#GO:0030234 peptidase complex#GO:1905368;protein-containing complex#GO:0032991;proteasome accessory complex#GO:0022624;proteasome regulatory particle#GO:0005838;catalytic complex#GO:1902494;proteasome regulatory particle, lid subcomplex#GO:0008541;proteasome complex#GO:0000502;endopeptidase complex#GO:1905369;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG177803|UniProtKB=T1FCA5 T1FCA5 20206454 PTHR44163:SF1 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;t-UTP complex#GO:0034455;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981;90S preribosome#GO:0030686;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG94814|UniProtKB=T1G932 T1G932 20217579 PTHR11254:SF429 HECT DOMAIN UBIQUITIN-PROTEIN LIGASE E3 UBIQUITIN-PROTEIN LIGASE SU(DX) transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 HELRO|EnsemblGenome=HelroG72710|UniProtKB=T1G142 T1G142 20214790 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG69055|UniProtKB=T1FZN8 T1FZN8 20214286 PTHR33273:SF4 DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175167|UniProtKB=T1F8Y3 T1F8Y3 20205282 PTHR13217:SF6 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052;Rho protein signal transduction#GO:0007266 HELRO|EnsemblGenome=HelroG163970|UniProtKB=T1EUP5 T1EUP5 20200295 PTHR15690:SF0 NUCLEAR RECEPTOR COACTIVATOR 6 NUCLEAR RECEPTOR COACTIVATOR 6 transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;nuclear receptor coactivator activity#GO:0030374;protein-macromolecule adaptor activity#GO:0030674 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;histone methyltransferase complex#GO:0035097;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;methyltransferase complex#GO:0034708;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG69008|UniProtKB=T1FZN3 T1FZN3 20214281 PTHR11205:SF19 RIBOSOMAL PROTEIN S7 SMALL RIBOSOMAL SUBUNIT PROTEIN US7M structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159;mRNA binding#GO:0003729;rRNA binding#GO:0019843 cellular component biogenesis#GO:0044085;peptide metabolic process#GO:0006518;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;translation#GO:0006412;protein-RNA complex assembly#GO:0022618;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;ribosome biogenesis#GO:0042254;non-membrane-bounded organelle assembly#GO:0140694;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;peptide biosynthetic process#GO:0043043;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;ribonucleoprotein complex biogenesis#GO:0022613;protein-RNA complex organization#GO:0071826;ribosomal small subunit biogenesis#GO:0042274 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG175226|UniProtKB=T1F916 T1F916 20205315 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162036|UniProtKB=T1ES63 T1ES63 20199413 PTHR44592:SF3 NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN SECRETED PROTEIN HELRO|EnsemblGenome=HelroG101151|UniProtKB=T1ED33 T1ED33 20194485 PTHR10635:SF0 COATOMER SUBUNIT BETA COATOMER SUBUNIT BETA localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;intra-Golgi vesicle-mediated transport#GO:0006891;establishment of localization#GO:0051234;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;vesicle coat#GO:0030120;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;Golgi-associated vesicle membrane#GO:0030660;protein-containing complex#GO:0032991;COPI vesicle coat#GO:0030126;endomembrane system#GO:0012505;membrane coat#GO:0030117;coated vesicle membrane#GO:0030662;COPI-coated vesicle#GO:0030137;Golgi-associated vesicle#GO:0005798;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;coated membrane#GO:0048475;cytoplasmic vesicle membrane#GO:0030659 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG68359|UniProtKB=T1FZD6 T1FZD6 20214184 PTHR11241:SF0 DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE cation binding#GO:0043169;pyrophosphatase activity#GO:0016462;magnesium ion binding#GO:0000287;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;metal ion binding#GO:0046872;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167 cellular aromatic compound metabolic process#GO:0006725;nucleoside triphosphate metabolic process#GO:0009141;pyrimidine nucleotide metabolic process#GO:0006220;carbohydrate derivative metabolic process#GO:1901135;heterocycle catabolic process#GO:0046700;organophosphate biosynthetic process#GO:0090407;pyrimidine-containing compound metabolic process#GO:0072527;organonitrogen compound catabolic process#GO:1901565;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;cellular nitrogen compound catabolic process#GO:0044270;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;nucleoside monophosphate metabolic process#GO:0009123;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;nucleoside phosphate catabolic process#GO:1901292;carbohydrate derivative catabolic process#GO:1901136;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;nucleoside triphosphate catabolic process#GO:0009143;cellular metabolic process#GO:0044237;nucleotide catabolic process#GO:0009166;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;organophosphate catabolic process#GO:0046434;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound catabolic process#GO:0019439;organic cyclic compound catabolic process#GO:1901361;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;small molecule metabolic process#GO:0044281;nucleobase-containing small molecule metabolic process#GO:0055086 metabolite interconversion enzyme#PC00262;phosphatase#PC00181 De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dUTP pyrophosphatase#P02918 HELRO|EnsemblGenome=HelroG108298|UniProtKB=T1EEI1 T1EEI1 20194983 PTHR12250:SF0 PHOSPHATIDYLINOSITOL GLYCAN, CLASS N GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;phospholipid biosynthetic process#GO:0008654;macromolecule modification#GO:0043412;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycolipid metabolic process#GO:0006664;protein modification process#GO:0036211;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;glycerolipid biosynthetic process#GO:0045017;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;organic substance biosynthetic process#GO:1901576;liposaccharide metabolic process#GO:1903509;cellular process#GO:0009987;GPI anchor metabolic process#GO:0006505;membrane lipid biosynthetic process#GO:0046467;lipoprotein biosynthetic process#GO:0042158;primary metabolic process#GO:0044238;GPI anchor biosynthetic process#GO:0006506;carbohydrate derivative biosynthetic process#GO:1901137;membrane lipid metabolic process#GO:0006643;glycerophospholipid biosynthetic process#GO:0046474;glycolipid biosynthetic process#GO:0009247;organophosphate metabolic process#GO:0019637;lipoprotein metabolic process#GO:0042157;cellular lipid metabolic process#GO:0044255 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 extracellular matrix glycoprotein#PC00100;extracellular matrix protein#PC00102 HELRO|EnsemblGenome=HelroG129899|UniProtKB=T1EHS7 T1EHS7 20196127 PTHR24347:SF427 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE DCLK3 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG178737|UniProtKB=T1FDN2 T1FDN2 20206931 PTHR19890:SF10 FIBROBLAST GROWTH FACTOR RECEPTOR FIBROBLAST GROWTH FACTOR RECEPTOR-LIKE 1 transmembrane signal receptor#PC00197;tyrosine protein kinase receptor#PC00233 HELRO|EnsemblGenome=HelroG81239|UniProtKB=T1G4C0 T1G4C0 20215918 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG80977|UniProtKB=T1G478 T1G478 20215876 PTHR11618:SF13 TRANSCRIPTION INITIATION FACTOR IIB-RELATED TRANSCRIPTION INITIATION FACTOR IIB cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;gene expression#GO:0010467;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;aromatic compound biosynthetic process#GO:0019438;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein-containing complex#GO:0032991;protein-DNA complex#GO:0032993 general transcription factor#PC00259 Transcription regulation by bZIP transcription factor#P00055>TFIIB#P01397;General transcription regulation#P00023>TFIIB#P00668 HELRO|EnsemblGenome=HelroG158602|UniProtKB=T1EN04 T1EN04 20197954 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG110803|UniProtKB=T1EF53 T1EF53 20195205 PTHR23049:SF71 MYOSIN REGULATORY LIGHT CHAIN 2 MYOSIN REGULATORY LIGHT CHAIN 1-RELATED cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;myosin binding#GO:0017022;binding#GO:0005488 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;myosin complex#GO:0016459;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG178017|UniProtKB=T1FCM2 T1FCM2 20206571 PTHR33562:SF31 ATILLA, ISOFORM B-RELATED-RELATED PROTEIN QUIVER HELRO|EnsemblGenome=HelroG185734|UniProtKB=T1FN78 T1FN78 20210276 PTHR11067:SF9 INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN INOSINE TRIPHOSPHATE PYROPHOSPHATASE pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;nucleoside triphosphate metabolic process#GO:0009141;heterocycle metabolic process#GO:0046483;nucleoside phosphate catabolic process#GO:1901292;heterocycle catabolic process#GO:0046700;nucleoside triphosphate catabolic process#GO:0009143;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate catabolic process#GO:0046434;phosphate-containing compound metabolic process#GO:0006796;cellular nitrogen compound catabolic process#GO:0044270;aromatic compound catabolic process#GO:0019439;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;organic cyclic compound catabolic process#GO:1901361;catabolic process#GO:0009056;organophosphate metabolic process#GO:0019637;organic substance catabolic process#GO:1901575;nucleobase-containing compound catabolic process#GO:0034655;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248;nucleobase-containing small molecule metabolic process#GO:0055086 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 nucleotide phosphatase#PC00173 Thiamin metabolism#P02780>Nucleoside triphosphatase#P03180 HELRO|EnsemblGenome=HelroG194054|UniProtKB=T1FVM4 T1FVM4 20212870 PTHR46961:SF8 DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN DYNEIN AXONEMAL HEAVY CHAIN 7 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG191497|UniProtKB=T1FT15 T1FT15 20211962 PTHR10159:SF519 DUAL SPECIFICITY PROTEIN PHOSPHATASE DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;dephosphorylation#GO:0016311;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein phosphatase#PC00195;protein modifying enzyme#PC00260 Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG75911|UniProtKB=T1G2C5 T1G2C5 20215223 PTHR24115:SF9 KINESIN-RELATED KINESIN HEAVY CHAIN cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;plus-end-directed microtubule motor activity#GO:0008574;binding#GO:0005488;catalytic activity#GO:0003824;cytoskeletal motor activity#GO:0003774;microtubule binding#GO:0008017;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887;pyrophosphatase activity#GO:0016462;microtubule motor activity#GO:0003777;ATP-dependent activity#GO:0140657;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817 localization#GO:0051179;cellular localization#GO:0051641;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;transport#GO:0006810;cytoskeleton-dependent intracellular transport#GO:0030705;microtubule-based movement#GO:0007018;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;microtubule associated complex#GO:0005875;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG112655|UniProtKB=T1EFL1 T1EFL1 20195363 PTHR10027:SF33 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic ion-gated channel activity#GO:0022839;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium-activated cation channel activity#GO:0005227;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG167080|UniProtKB=T1EYZ9 T1EYZ9 20201799 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG182721|UniProtKB=T1FIN1 T1FIN1 20208680 PTHR22014:SF2 RNA-BINDING PROTEIN 33 RNA-BINDING PROTEIN 33 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 HELRO|EnsemblGenome=HelroG172407|UniProtKB=T1F5A1 T1F5A1 20204000 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG172109|UniProtKB=T1F514 T1F514 20203913 PTHR46961:SF11 DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN DYNEIN HEAVY CHAIN LINKER DOMAIN-CONTAINING PROTEIN microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG69003|UniProtKB=T1FZN2 T1FZN2 20214280 PTHR24072:SF359 RHO FAMILY GTPASE RAS-RELATED PROTEIN RAC1-RELATED GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;enzyme binding#GO:0019899;ribonucleoside triphosphate phosphatase activity#GO:0017111;kinase binding#GO:0019900;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817;protein kinase binding#GO:0019901;anion binding#GO:0043168;ion binding#GO:0043167 establishment or maintenance of cell polarity#GO:0007163;regulation of anatomical structure morphogenesis#GO:0022603;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cytoskeleton organization#GO:0051493;regulation of cell shape#GO:0008360;regulation of biological quality#GO:0065008;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;organelle organization#GO:0006996;cortical cytoskeleton organization#GO:0030865;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;regulation of actin filament-based process#GO:0032970 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 small GTPase#PC00208 T cell activation#P00053>rac#P01324;Huntington disease#P00029>Rac#P00775;Cytoskeletal regulation by Rho GTPase#P00016>Rac#P00523;EGF receptor signaling pathway#P00018>Rac#P00564;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Cdc42#P00834;Ras Pathway#P04393>Rac#P04559;Axon guidance mediated by netrin#P00009>Rac#P00366;Integrin signalling pathway#P00034>Rac#P00927;Axon guidance mediated by Slit/Robo#P00008>Rac#P00354;FGF signaling pathway#P00021>Rac#P00645 HELRO|EnsemblGenome=HelroG187800|UniProtKB=T1FPD9 T1FPD9 20210686 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG109220|UniProtKB=T1EER5 T1EER5 20195067 PTHR22588:SF3 VWFA DOMAIN-CONTAINING PROTEIN VWFA DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167563|UniProtKB=T1EZH8 T1EZH8 20201978 PTHR24543:SF291 MULTICOPPER OXIDASE-RELATED SMOKE ALARM, ISOFORM D oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG73094|UniProtKB=T1G198 T1G198 20214846 PTHR11827:SF72 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS GH08340P secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG170138|UniProtKB=T1F2P5 T1F2P5 20203094 PTHR46607:SF1 SEC14 DOMAIN AND SPECTRIN REPEAT-CONTAINING PROTEIN 1 SEC14 DOMAIN AND SPECTRIN REPEAT-CONTAINING PROTEIN 1 phosphatidylinositol-3-phosphate binding#GO:0032266;phosphatidylinositol bisphosphate binding#GO:1902936;small molecule binding#GO:0036094;binding#GO:0005488;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;lipid binding#GO:0008289;anion binding#GO:0043168;ion binding#GO:0043167;phosphatidylinositol binding#GO:0035091;phosphatidylinositol phosphate binding#GO:1901981;phospholipid binding#GO:0005543 HELRO|EnsemblGenome=HelroG181587|UniProtKB=T1FH50 T1FH50 20208149 PTHR23253:SF78 EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA EUKARYOTIC TRANSLATION INITIATION FACTOR 4G1, ISOFORM B-RELATED nucleic acid binding#GO:0003676;translation regulator activity#GO:0045182;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation initiation factor activity#GO:0003743;mRNA binding#GO:0003729;translation regulator activity, nucleic acid binding#GO:0090079;translation factor activity, RNA binding#GO:0008135 cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG192685|UniProtKB=T1FU69 T1FU69 20212365 PTHR11188:SF144 ARRESTIN DOMAIN CONTAINING PROTEIN ARRESTIN C-TERMINAL-LIKE DOMAIN-CONTAINING PROTEIN localization#GO:0051179;organic substance transport#GO:0071702;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;protein transport#GO:0015031;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG159334|UniProtKB=T1ENW5 T1ENW5 20198265 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG183853|UniProtKB=T1FK98 T1FK98 20209247 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG119925|UniProtKB=T1EGP0 T1EGP0 20195740 PTHR11062:SF129 EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED EXOSTOSIN-1 acetylglucosaminyltransferase activity#GO:0008375;glucuronosyltransferase activity#GO:0015020;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG159064|UniProtKB=T1ENJ7 T1ENJ7 20198147 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165041|UniProtKB=T1EW65 T1EW65 20200815 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164696|UniProtKB=T1EVQ6 T1EVQ6 20200656 PTHR11259:SF2 RAS-RELATED GTP BINDING RAG/GTR YEAST GH16429P GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of catabolic process#GO:0009894;positive regulation of signal transduction#GO:0009967;regulation of signaling#GO:0023051;response to extracellular stimulus#GO:0009991;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;positive regulation of response to stimulus#GO:0048584;cellular response to starvation#GO:0009267;positive regulation of TOR signaling#GO:0032008;regulation of signal transduction#GO:0009966;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;cellular response to extracellular stimulus#GO:0031668;regulation of cell communication#GO:0010646;positive regulation of TORC1 signaling#GO:1904263;cellular response to stimulus#GO:0051716;regulation of TORC1 signaling#GO:1903432;regulation of autophagy#GO:0010506;negative regulation of cellular catabolic process#GO:0031330;negative regulation of metabolic process#GO:0009892;cell communication#GO:0007154;response to nutrient levels#GO:0031667;regulation of cellular catabolic process#GO:0031329;negative regulation of autophagy#GO:0010507;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to stress#GO:0006950;negative regulation of catabolic process#GO:0009895;regulation of cellular process#GO:0050794;cellular response to nutrient levels#GO:0031669;response to starvation#GO:0042594;positive regulation of cell communication#GO:0010647;biological regulation#GO:0065007;cellular response to external stimulus#GO:0071496;cellular response to stress#GO:0033554;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;lysosome#GO:0005764;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;lytic vacuole#GO:0000323;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG78720|UniProtKB=T1G3F0 T1G3F0 20215598 PTHR12192:SF26 CATION TRANSPORT PROTEIN CHAC-RELATED GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 1 lyase activity#GO:0016829;catalytic activity#GO:0003824 sulfur compound metabolic process#GO:0006790;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;peptide catabolic process#GO:0043171;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;cellular process#GO:0009987;glutathione metabolic process#GO:0006749;sulfur compound catabolic process#GO:0044273;nitrogen compound metabolic process#GO:0006807;cellular modified amino acid metabolic process#GO:0006575;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG71005|UniProtKB=T1G0F5 T1G0F5 20214553 PTHR11183:SF100 GLYCOGENIN SUBFAMILY MEMBER GLYCOGENIN, ISOFORM E transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG186284|UniProtKB=T1FNX0 T1FNX0 20210517 PTHR11699:SF211 ALDEHYDE DEHYDROGENASE-RELATED ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1 dehydrogenase#PC00092;oxidoreductase#PC00176 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402;Ornithine degradation#P02758>Aminobutyraldehyde dehydrogenase#P03055;Phenylethylamine degradation#P02766>Phenylacetaldehyde dehydrogenase#P03102 HELRO|EnsemblGenome=HelroG83596|UniProtKB=T1G578 T1G578 20216226 PTHR21244:SF1 MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S24 SMALL RIBOSOMAL SUBUNIT PROTEIN US3M macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;translation#GO:0006412;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG192976|UniProtKB=T1FUH1 T1FUH1 20212467 PTHR23255:SF71 TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II RECEPTOR PROTEIN SERINE_THREONINE KINASE transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to endogenous stimulus#GO:0071495;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;response to growth factor#GO:0070848;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;response to stimulus#GO:0050896;response to endogenous stimulus#GO:0009719;cellular response to growth factor stimulus#GO:0071363;nitrogen compound metabolic process#GO:0006807;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 serine/threonine protein kinase receptor#PC00205 Wnt signaling pathway#P00057>TGFbetaactivated Kinase-1#P01442;Activin beta signaling pathway#P06210>BABO#P06231;ALP23B signaling pathway#P06209>BABO#P06220;MYO signaling pathway#P06215>BABO#P06310;TGF-beta signaling pathway#P00052>TGFbetareceptor I#P01278;TGF-beta signaling pathway#P00052>TGFbetareceptors#P01283;BMP/activin signaling pathway-drosophila#P06211>TGFbetaR I#P06241;TGF-beta signaling pathway#P00052>TGFbetareceptor II#P01277 HELRO|EnsemblGenome=HelroG185992|UniProtKB=T1FNJ0 T1FNJ0 20210387 PTHR11850:SF108 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS HOMEOBOX PROTEIN EXTRADENTICLE cellular developmental process#GO:0048869;neurogenesis#GO:0022008;animal organ development#GO:0048513;multicellular organism development#GO:0007275;developmental process#GO:0032502;cellular process#GO:0009987;nervous system development#GO:0007399;cell development#GO:0048468;system development#GO:0048731;embryonic organ development#GO:0048568;cell differentiation#GO:0030154;embryo development#GO:0009790;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;neuron differentiation#GO:0030182;animal organ morphogenesis#GO:0009887;neuron development#GO:0048666;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG185938|UniProtKB=T1FNG7 T1FNG7 20210364 PTHR12474:SF0 P53 REGULATED PA26 NUCLEAR PROTEIN SESTRIN SESTRIN HOMOLOG amino acid binding#GO:0016597;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;carboxylic acid binding#GO:0031406;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;organic acid binding#GO:0043177;anion binding#GO:0043168;ion binding#GO:0043167;oxidoreductase activity#GO:0016491 negative regulation of biological process#GO:0048519;regulation of catabolic process#GO:0009894;negative regulation of intracellular signal transduction#GO:1902532;positive regulation of cellular metabolic process#GO:0031325;regulation of signaling#GO:0023051;positive regulation of cellular catabolic process#GO:0031331;response to extracellular stimulus#GO:0009991;regulation of intracellular signal transduction#GO:1902531;cellular response to nitrogen compound#GO:1901699;negative regulation of TOR signaling#GO:0032007;regulation of biological process#GO:0050789;cellular response to oxygen-containing compound#GO:1901701;response to endogenous stimulus#GO:0009719;cellular response to starvation#GO:0009267;positive regulation of metabolic process#GO:0009893;regulation of signal transduction#GO:0009966;positive regulation of biological process#GO:0048518;negative regulation of cell communication#GO:0010648;negative regulation of cellular process#GO:0048523;cellular response to extracellular stimulus#GO:0031668;response to organic substance#GO:0010033;regulation of cell communication#GO:0010646;cellular response to stimulus#GO:0051716;regulation of TORC1 signaling#GO:1903432;cellular response to endogenous stimulus#GO:0071495;negative regulation of response to stimulus#GO:0048585;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;cellular response to organic substance#GO:0071310;regulation of autophagy#GO:0010506;negative regulation of signaling#GO:0023057;cell communication#GO:0007154;regulation of macroautophagy#GO:0016241;response to organonitrogen compound#GO:0010243;response to nutrient levels#GO:0031667;regulation of cellular catabolic process#GO:0031329;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to external stimulus#GO:0009605;response to stress#GO:0006950;positive regulation of macroautophagy#GO:0016239;response to chemical#GO:0042221;cellular response to nutrient levels#GO:0031669;cellular response to organonitrogen compound#GO:0071417;regulation of cellular process#GO:0050794;response to starvation#GO:0042594;biological regulation#GO:0065007;cellular response to external stimulus#GO:0071496;positive regulation of catabolic process#GO:0009896;negative regulation of signal transduction#GO:0009968;positive regulation of autophagy#GO:0010508;cellular response to amino acid starvation#GO:0034198;negative regulation of TORC1 signaling#GO:1904262;cellular response to stress#GO:0033554;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 peroxidase#PC00180;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG177513|UniProtKB=T1FBT8 T1FBT8 20206287 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164700|UniProtKB=T1EVQ9 T1EVQ9 20200659 PTHR19871:SF14 BETA TRANSDUCIN-RELATED PROTEIN DUF4062 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173827|UniProtKB=T1F7A5 T1F7A5 20204704 PTHR45749:SF21 FAMILY NOT NAMED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG87434|UniProtKB=T1G6P9 T1G6P9 20216746 PTHR10344:SF1 THYMIDYLATE KINASE THYMIDYLATE KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;phosphotransferase activity, phosphate group as acceptor#GO:0016776 cellular aromatic compound metabolic process#GO:0006725;nucleoside triphosphate metabolic process#GO:0009141;pyrimidine nucleotide metabolic process#GO:0006220;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;pyrimidine-containing compound metabolic process#GO:0072527;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;nucleoside diphosphate metabolic process#GO:0009132;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 nucleotide kinase#PC00172 De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dTMP kinase#P02916 HELRO|EnsemblGenome=HelroG183602|UniProtKB=T1FJW9 T1FJW9 20209118 PTHR20956:SF12 HEH2P FLYWCH-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189665|UniProtKB=T1FR87 T1FR87 20211334 PTHR48031:SF2 SRA STEM-LOOP-INTERACTING RNA-BINDING PROTEIN, MITOCHONDRIAL RNA-BINDING PROTEIN 4 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 HELRO|EnsemblGenome=HelroG170854|UniProtKB=T1F3I5 T1F3I5 20203384 PTHR43981:SF2 ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL lipid metabolic process#GO:0006629;oxoacid metabolic process#GO:0043436;fatty acid metabolic process#GO:0006631;cellular metabolic process#GO:0044237;cellular process#GO:0009987;cellular lipid metabolic process#GO:0044255;organic acid metabolic process#GO:0006082;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 reductase#PC00198;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG173386|UniProtKB=T1F6R5 T1F6R5 20204514 PTHR13168:SF0 ASSOCIATE OF C-MYC AMY-1 C-MYC-BINDING PROTEIN transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;protein-macromolecule adaptor activity#GO:0030674 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transcription cofactor#PC00217 PDGF signaling pathway#P00047>c-Myc#P01172 HELRO|EnsemblGenome=HelroG192510|UniProtKB=T1FU14 T1FU14 20212310 PTHR45691:SF6 PROTEIN DIAPHANOUS PROTEIN DIAPHANOUS cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-containing complex assembly#GO:0065003;actin polymerization or depolymerization#GO:0008154;actin filament polymerization#GO:0030041;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;protein polymerization#GO:0051258;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036 supramolecular complex#GO:0099080;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;supramolecular fiber#GO:0099512;supramolecular polymer#GO:0099081;actin filament#GO:0005884;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG89375|UniProtKB=T1G7C5 T1G7C5 20216972 PTHR10366:SF853 NAD DEPENDENT EPIMERASE/DEHYDRATASE GH25466P oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG169963|UniProtKB=T1F2H6 T1F2H6 20203026 PTHR19282:SF534 TETRASPANIN TETRASPANIN FAMILY-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185743|UniProtKB=T1FN82 T1FN82 20210280 PTHR12290:SF11 CORNICHON-RELATED PROTEIN CORNICHON membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG167438|UniProtKB=T1EZD6 T1EZD6 20201936 PTHR16021:SF23 MANSC DOMAIN CONTAINING PROTEIN 1 FI18411P1-RELATED HELRO|EnsemblGenome=HelroG189549|UniProtKB=T1FR51 T1FR51 20211298 PTHR12019:SF9 LAMINA-ASSOCIATED POLYPEPTIDE THYMOPOIETIN THYMOPOIETIN peptide hormone#PC00179 HELRO|EnsemblGenome=HelroG159107|UniProtKB=T1ENL6 T1ENL6 20198166 PTHR45695:SF15 LEUCOKININ RECEPTOR-RELATED OPSIN RH2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Rhodopsin#P00747 HELRO|EnsemblGenome=HelroG132254|UniProtKB=T1EHX5 T1EHX5 20196175 PTHR13572:SF4 ENDO-ALPHA-1,2-MANNOSIDASE RE57134P hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG186840|UniProtKB=T1FP41 T1FP41 20210588 PTHR19375:SF395 HEAT SHOCK PROTEIN 70KDA HEAT SHOCK 70 KDA PROTEIN ISOFORM X1-RELATED cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 Hsp70 family chaperone#PC00027 Parkinson disease#P00049>Hsp70#P01208;Apoptosis signaling pathway#P00006>HSP70#P00321 HELRO|EnsemblGenome=HelroG168983|UniProtKB=T1F180 T1F180 20202580 PTHR15907:SF182 DUF614 FAMILY PROTEIN-RELATED PROTEIN PLANT CADMIUM RESISTANCE 1-RELATED HELRO|EnsemblGenome=HelroG112954|UniProtKB=T1EFN5 T1EFN5 20195387 PTHR11629:SF63 VACUOLAR PROTON ATPASES V-TYPE PROTON ATPASE SUBUNIT A enzyme binding#GO:0019899;protein binding#GO:0005515;binding#GO:0005488 regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;regulation of biological quality#GO:0065008;intracellular monoatomic cation homeostasis#GO:0030003;biological regulation#GO:0065007;intracellular pH reduction#GO:0051452;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic ion homeostasis#GO:0006873;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;vacuolar acidification#GO:0007035;regulation of cellular pH#GO:0030641;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;vacuolar membrane#GO:0005774;ATPase complex#GO:1904949;vacuole#GO:0005773;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;proton-transporting two-sector ATPase complex#GO:0016469;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG155828|UniProtKB=T1ELN0 T1ELN0 20197480 PTHR45732:SF7 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8 Huntington disease#P00029>ARF#P00786 HELRO|EnsemblGenome=HelroG161252|UniProtKB=T1ER94 T1ER94 20199094 PTHR10145:SF6 TRANSCRIPTION ELONGATION FACTOR SPT6 TRANSCRIPTION ELONGATION FACTOR SPT6 nucleosome binding#GO:0031491;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;histone binding#GO:0042393;binding#GO:0005488;chromatin binding#GO:0003682 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;protein-DNA complex organization#GO:0071824;nucleosome organization#GO:0034728;RNA metabolic process#GO:0016070;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;transcription elongation by RNA polymerase II#GO:0006368;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;DNA-templated transcription elongation#GO:0006354;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;chromatin organization#GO:0006325;aromatic compound biosynthetic process#GO:0019438;chromatin remodeling#GO:0006338;transcription by RNA polymerase II#GO:0006366 membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;transcription elongation factor complex#GO:0008023;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG162802|UniProtKB=T1ET65 T1ET65 20199765 PTHR46670:SF2 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG128998|UniProtKB=T1EHR3 T1EHR3 20196113 PTHR45628:SF1 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1 calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated calcium channel activity#GO:0005245;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;calcium ion transport#GO:0006816;localization#GO:0051179;calcium ion import#GO:0070509;import across plasma membrane#GO:0098739;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;calcium ion transmembrane import into cytosol#GO:0097553;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657 voltage-gated calcium channel complex#GO:0005891;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;calcium channel complex#GO:0034704;membrane#GO:0016020;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 Beta2 adrenergic receptor signaling pathway#P04378>Ca2+ channel#P04445;Beta1 adrenergic receptor signaling pathway#P04377>Ca2+ channel#P04438;Alzheimer disease-amyloid secretase pathway#P00003>L-type calcium channels#P00082;Oxytocin receptor mediated signaling pathway#P04391>Ca2+ channel#P04535;5HT2 type receptor mediated signaling pathway#P04374>Ca2+ channel#P04411;Nicotinic acetylcholine receptor signaling pathway#P00044>Ca2+ channel#P01096 HELRO|EnsemblGenome=HelroG177443|UniProtKB=T1FBP9 T1FBP9 20206248 PTHR35711:SF1 EXPRESSED PROTEIN ECTODERMAL, ISOFORM F HELRO|EnsemblGenome=HelroG175377|UniProtKB=T1F977 T1F977 20205376 PTHR34586:SF3 SPERACT/SCAVENGER RECEPTOR DOMAIN-CONTAINING PROTEIN FOLLISTATIN-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176277|UniProtKB=T1FAD0 T1FAD0 20205779 PTHR23302:SF43 TRANSMEMBRANE CHANNEL-RELATED TMC DOMAIN-CONTAINING PROTEIN passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;channel activity#GO:0015267;gated channel activity#GO:0022836;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG170561|UniProtKB=T1F367 T1F367 20203266 PTHR21346:SF0 FUN14 DOMAIN CONTAINING RE45833P process utilizing autophagic mechanism#GO:0061919;cellular component organization or biogenesis#GO:0071840;cellular component disassembly#GO:0022411;organelle organization#GO:0006996;catabolic process#GO:0009056;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;autophagy of mitochondrion#GO:0000422;mitochondrion organization#GO:0007005;cellular process#GO:0009987;organelle disassembly#GO:1903008;autophagy#GO:0006914;cellular catabolic process#GO:0044248;metabolic process#GO:0008152 envelope#GO:0031975;bounding membrane of organelle#GO:0098588;mitochondrial membrane#GO:0031966;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867 HELRO|EnsemblGenome=HelroG105872|UniProtKB=T1EDY0 T1EDY0 20194782 PTHR19846:SF0 WD40 REPEAT PROTEIN PRE-MRNA PROCESSING FACTOR 4 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 mRNA splicing#P00058>U4#P01476;mRNA splicing#P00058>U6#P01473 HELRO|EnsemblGenome=HelroG164115|UniProtKB=T1EUY2 T1EUY2 20200382 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192237|UniProtKB=T1FTR0 T1FTR0 20212207 PTHR48407:SF1 CRANIOFACIAL DEVELOPMENT PROTEIN 1 CRANIOFACIAL DEVELOPMENT PROTEIN 1 HELRO|EnsemblGenome=HelroG162670|UniProtKB=T1ESZ9 T1ESZ9 20199699 PTHR19282:SF456 TETRASPANIN CD63 MOLECULE cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG172902|UniProtKB=T1F637 T1F637 20204286 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188119|UniProtKB=T1FPN7 T1FPN7 20210784 PTHR10285:SF224 URIDINE KINASE URIDINE-CYTIDINE KINASE cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 nucleotide kinase#PC00172 Salvage pyrimidine ribonucleotides#P02775>Uridine kinase#P03150;Salvage pyrimidine ribonucleotides#P02775>Cytidine kinase#P03149;Salvage pyrimidine ribonucleotides#P02775>CDP kinase#P03156 HELRO|EnsemblGenome=HelroG119785|UniProtKB=T1EGN6 T1EGN6 20195736 PTHR24351:SF209 RIBOSOMAL PROTEIN S6 KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG158630|UniProtKB=T1EN15 T1EN15 20197965 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166764|UniProtKB=T1EYH6 T1EYH6 20201626 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG108178|UniProtKB=T1EEG2 T1EEG2 20194964 PTHR15627:SF8 NATURAL KILLER CELL-SPECIFIC ANTIGEN KLIP1 TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 1 HELRO|EnsemblGenome=HelroG74811|UniProtKB=T1G1W0 T1G1W0 20215058 PTHR20991:SF0 PARATHYROID HORMONE-RESPONSIVE B1 GENE PROTEIN PTHB1 organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;BBSome#GO:0034464;membrane#GO:0016020;cilium#GO:0005929;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025 HELRO|EnsemblGenome=HelroG102735|UniProtKB=T1EDB3 T1EDB3 20194565 PTHR10536:SF0 DNA PRIMASE SMALL SUBUNIT DNA PRIMASE SMALL SUBUNIT catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;RNA polymerase activity#GO:0097747;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nucleobase-containing compound biosynthetic process#GO:0034654;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated DNA replication#GO:0006261;aromatic compound biosynthetic process#GO:0019438;DNA replication#GO:0006260;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 primase#PC00189 DNA replication#P00017>Primase#P00528 HELRO|EnsemblGenome=HelroG162338|UniProtKB=T1ESI8 T1ESI8 20199538 PTHR11601:SF34 CYSTEINE DESULFURYLASE FAMILY MEMBER CYSTEINE DESULFURASE lyase#PC00144 HELRO|EnsemblGenome=HelroG107695|UniProtKB=T1EEC3 T1EEC3 20194925 PTHR13848:SF2 PROTEIN YIPPEE-LIKE CG15309-RELATED PROTEIN YIPPEE-LIKE ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG195013|UniProtKB=T1FWN4 T1FWN4 20213229 PTHR11850:SF108 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS HOMEOBOX PROTEIN EXTRADENTICLE cellular developmental process#GO:0048869;neurogenesis#GO:0022008;animal organ development#GO:0048513;multicellular organism development#GO:0007275;developmental process#GO:0032502;cellular process#GO:0009987;nervous system development#GO:0007399;cell development#GO:0048468;system development#GO:0048731;embryonic organ development#GO:0048568;cell differentiation#GO:0030154;embryo development#GO:0009790;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;neuron differentiation#GO:0030182;animal organ morphogenesis#GO:0009887;neuron development#GO:0048666;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG182479|UniProtKB=T1FI92 T1FI92 20208541 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG179160|UniProtKB=T1FEA3 T1FEA3 20207152 PTHR10334:SF590 CYSTEINE-RICH SECRETORY PROTEIN-RELATED SCP DOMAIN-CONTAINING PROTEIN extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG192132|UniProtKB=T1FTM0 T1FTM0 20212167 PTHR22950:SF652 AMINO ACID TRANSPORTER TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN L-amino acid transmembrane transporter activity#GO:0015179;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;amino acid transport#GO:0006865;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;nitrogen compound transport#GO:0071705;organic acid transmembrane transport#GO:1903825;carboxylic acid transport#GO:0046942;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039 cellular anatomical entity#GO:0110165;membrane#GO:0016020 amino acid transporter#PC00046;transporter#PC00227 HELRO|EnsemblGenome=HelroG189580|UniProtKB=T1FR61 T1FR61 20211308 PTHR46753:SF3 FYVE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1 PDZ DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190631|UniProtKB=T1FS57 T1FS57 20211654 PTHR10855:SF2 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4 COP9 SIGNALOSOME COMPLEX SUBUNIT 4 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;COP9 signalosome#GO:0008180;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 protease#PC00190 HELRO|EnsemblGenome=HelroG116604|UniProtKB=T1EGG4 T1EGG4 20195666 PTHR24006:SF758 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36 cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG85277|UniProtKB=T1G5V0 T1G5V0 20216447 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG74475|UniProtKB=T1G1R6 T1G1R6 20215014 PTHR22996:SF0 MAHOGUNIN RE60872P-RELATED transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG80823|UniProtKB=T1G460 T1G460 20215858 PTHR19143:SF444 FIBRINOGEN/TENASCIN/ANGIOPOEITIN PROTEIN SCABROUS external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG179323|UniProtKB=T1FEJ6 T1FEJ6 20207245 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG72163|UniProtKB=T1G0W6 T1G0W6 20214714 PTHR11537:SF105 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAL monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG178484|UniProtKB=T1FD89 T1FD89 20206788 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191730|UniProtKB=T1FT86 T1FT86 20212033 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG75909|UniProtKB=T1G2C4 T1G2C4 20215222 PTHR21660:SF1 THIOESTERASE SUPERFAMILY MEMBER-RELATED ACYL-COENZYME A THIOESTERASE 13 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;fatty acyl-CoA hydrolase activity#GO:0047617;catalytic activity#GO:0003824;thiolester hydrolase activity#GO:0016790 esterase#PC00097 HELRO|EnsemblGenome=HelroG86209|UniProtKB=T1G685 T1G685 20216582 PTHR46030:SF1 ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6 ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG194134|UniProtKB=T1FVQ6 T1FVQ6 20212902 PTHR13859:SF11 ATROPHIN-RELATED GRUNGE, ISOFORM J transcription coregulator activity#GO:0003712;molecular adaptor activity#GO:0060090;transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;protein-macromolecule adaptor activity#GO:0030674 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG180380|UniProtKB=T1FFV0 T1FFV0 20207699 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG163386|UniProtKB=T1ETZ6 T1ETZ6 20200046 PTHR31802:SF3 32 KDA HEAT SHOCK PROTEIN-RELATED 32 KDA HEAT SHOCK PROTEIN intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG163577|UniProtKB=T1EU86 T1EU86 20200136 PTHR33244:SF3 INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED PEPTIDASE A2 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165086|UniProtKB=T1EW99 T1EW99 20200849 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG193589|UniProtKB=T1FV54 T1FV54 20212700 PTHR11945:SF23 MADS BOX PROTEIN MYOCYTE-SPECIFIC ENHANCER FACTOR 2D sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;cell differentiation#GO:0030154;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 MADS box transcription factor#PC00250 CCKR signaling map#P06959>MEF2D#P07048;p38 MAPK pathway#P05918>MEF#P06023;CCKR signaling map#P06959>MEF2#P07032 HELRO|EnsemblGenome=HelroG186406|UniProtKB=T1FNZ2 T1FNZ2 20210539 PTHR21229:SF1 LUNG SEVEN TRANSMEMBRANE RECEPTOR GH17801P localization#GO:0051179;establishment of localization#GO:0051234;transport#GO:0006810 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG176744|UniProtKB=T1FAV3 T1FAV3 20205952 PTHR46468:SF1 SENTRIN-SPECIFIC PROTEASE 8 SENTRIN-SPECIFIC PROTEASE 8 hydrolase activity#GO:0016787;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein modification by small protein removal#GO:0070646;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protease#PC00190 HELRO|EnsemblGenome=HelroG190914|UniProtKB=T1FSE9 T1FSE9 20211746 PTHR24214:SF38 PDZ AND LIM DOMAIN PROTEIN ZASP PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG185691|UniProtKB=T1FN56 T1FN56 20210254 PTHR13238:SF0 PROTEIN C21ORF59 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 298 HELRO|EnsemblGenome=HelroG180432|UniProtKB=T1FFX0 T1FFX0 20207719 PTHR12894:SF27 CNH DOMAIN CONTAINING TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1 vesicle fusion#GO:0006906;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular process#GO:0009987;localization#GO:0051179;process utilizing autophagic mechanism#GO:0061919;cellular component organization or biogenesis#GO:0071840;membrane fusion#GO:0061025;establishment of localization#GO:0051234;organelle organization#GO:0006996;catabolic process#GO:0009056;vesicle organization#GO:0016050;autophagy#GO:0006914;organelle fusion#GO:0048284;metabolic process#GO:0008152;cellular catabolic process#GO:0044248 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG161586|UniProtKB=T1ERN6 T1ERN6 20199236 PTHR13297:SF5 TBC1 DOMAIN FAMILY MEMBER 23-RELATED TBC1 DOMAIN FAMILY MEMBER 23 endosomal transport#GO:0016197;cellular localization#GO:0051641;organelle localization#GO:0051640;vesicle localization#GO:0051648;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;vesicle targeting#GO:0006903;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;establishment of vesicle localization#GO:0051650;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;establishment of organelle localization#GO:0051656 cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi apparatus subcompartment#GO:0098791;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG76512|UniProtKB=T1G2K7 T1G2K7 20215305 PTHR22838:SF0 WD REPEAT PROTEIN 26-RELATED WD REPEAT-CONTAINING PROTEIN 26 HELRO|EnsemblGenome=HelroG167572|UniProtKB=T1EZI1 T1EZI1 20201981 PTHR45617:SF170 LEUCINE RICH REPEAT FAMILY PROTEIN MIP14966P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG179275|UniProtKB=T1FEG8 T1FEG8 20207217 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG166276|UniProtKB=T1EXY9 T1EXY9 20201439 PTHR21669:SF28 CAPZ-INTERACTING PROTEIN AND RELATED PROTEINS YEMANUCLEIN cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;protein-DNA complex organization#GO:0071824;cellular component organization#GO:0016043;cellular process#GO:0009987;protein-containing complex organization#GO:0043933 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG167133|UniProtKB=T1EZ24 T1EZ24 20201824 PTHR35936:SF19 MEMBRANE-BOUND LYTIC MUREIN TRANSGLYCOSYLASE F AMINO-ACID-BINDING PROTEIN YXEM-RELATED HELRO|EnsemblGenome=HelroG104028|UniProtKB=T1EDJ2 T1EDJ2 20194644 PTHR19375:SF144 HEAT SHOCK PROTEIN 70KDA ENDOPLASMIC RETICULUM CHAPERONE BIP signal transduction#GO:0007165;endoplasmic reticulum unfolded protein response#GO:0030968;protein catabolic process#GO:0030163;organonitrogen compound catabolic process#GO:1901565;regulation of biological process#GO:0050789;nitrogen compound metabolic process#GO:0006807;response to unfolded protein#GO:0006986;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;signaling#GO:0023052;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;response to organic substance#GO:0010033;macromolecule catabolic process#GO:0009057;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;cellular response to chemical stimulus#GO:0070887;cellular response to organic substance#GO:0071310;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;ERAD pathway#GO:0036503;cell communication#GO:0007154;response to organonitrogen compound#GO:0010243;cellular process#GO:0009987;cellular response to topologically incorrect protein#GO:0035967;primary metabolic process#GO:0044238;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;response to topologically incorrect protein#GO:0035966;cellular response to unfolded protein#GO:0034620;biological regulation#GO:0065007;cellular response to stress#GO:0033554 membrane-enclosed lumen#GO:0031974;endoplasmic reticulum protein-containing complex#GO:0140534;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum lumen#GO:0005788;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783 Hsp70 family chaperone#PC00027 Parkinson disease#P00049>Hsp70#P01208;Apoptosis signaling pathway#P00006>HSP70#P00321 HELRO|EnsemblGenome=HelroG97048|UniProtKB=T1G9F1 T1G9F1 20217698 PTHR10680:SF28 PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 oxygenase#PC00177 HELRO|EnsemblGenome=HelroG97947|UniProtKB=T1G9J7 T1G9J7 20217743 PTHR11700:SF8 30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER 40S RIBOSOMAL PROTEIN S20 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic small ribosomal subunit#GO:0022627;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;small ribosomal subunit#GO:0015935;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG110857|UniProtKB=T1EF57 T1EF57 20195209 PTHR43674:SF2 NITRILASE C965.09-RELATED BETA-UREIDOPROPIONASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824 hydrolase#PC00121 Pyrimidine Metabolism#P02771>Beta-Ureidopropionase#P03127 HELRO|EnsemblGenome=HelroG89946|UniProtKB=T1G7J3 T1G7J3 20217040 PTHR23255:SF98 TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II SERINE_THREONINE-PROTEIN KINASE RECEPTOR signaling receptor activity#GO:0038023;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888;transferase activity#GO:0016740;transmembrane receptor protein kinase activity#GO:0019199;transmembrane receptor protein serine/threonine kinase activity#GO:0004675;protein serine/threonine kinase activity#GO:0004674;molecular transducer activity#GO:0060089;activin binding#GO:0048185;protein-containing complex binding#GO:0044877;catalytic activity, acting on a protein#GO:0140096 signal transduction#GO:0007165;macromolecule modification#GO:0043412;response to growth factor#GO:0070848;protein modification process#GO:0036211;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;response to endogenous stimulus#GO:0009719;nitrogen compound metabolic process#GO:0006807;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular response to stimulus#GO:0051716;cellular response to endogenous stimulus#GO:0071495;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;organonitrogen compound metabolic process#GO:1901564;protein phosphorylation#GO:0006468;cell communication#GO:0007154;cellular process#GO:0009987;activin receptor signaling pathway#GO:0032924;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;cellular response to growth factor stimulus#GO:0071363;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0007178;biological regulation#GO:0065007 receptor complex#GO:0043235;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;plasma membrane signaling receptor complex#GO:0098802;catalytic complex#GO:1902494;transferase complex#GO:1990234;plasma membrane protein complex#GO:0098797;serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886;transferase complex, transferring phosphorus-containing groups#GO:0061695 serine/threonine protein kinase receptor#PC00205 GBB signaling pathway#P06214>PUT#P06304;DPP signaling pathway#P06213>PUT#P06277;ALP23B signaling pathway#P06209>PUT#P06218;BMP/activin signaling pathway-drosophila#P06211>TGFbetaR II#P06255;TGF-beta signaling pathway#P00052>TGFbetareceptors#P01283;SCW signaling pathway#P06216>PUT#P06320;TGF-beta signaling pathway#P00052>TGFbetareceptor II#P01277;Activin beta signaling pathway#P06210>PUT#P06229;DPP-SCW signaling pathway#P06212>PUT#P06270 HELRO|EnsemblGenome=HelroG172968|UniProtKB=T1F683 T1F683 20204332 PTHR46420:SF1 BETA-1,4-GLUCURONYLTRANSFERASE 1 BETA-1,4-GLUCURONYLTRANSFERASE 1 glucuronosyltransferase activity#GO:0015020;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;protein O-linked mannosylation#GO:0035269;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein mannosylation#GO:0035268;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085;mannosylation#GO:0097502 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG160114|UniProtKB=T1EPT7 T1EPT7 20198587 PTHR46880:SF5 RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176190|UniProtKB=T1FAA1 T1FAA1 20205750 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG153353|UniProtKB=T1EL48 T1EL48 20197373 PTHR46289:SF17 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG108507|UniProtKB=T1EEJ6 T1EEJ6 20194998 PTHR10807:SF73 MYOTUBULARIN-RELATED LD06050P hydrolase activity, acting on ester bonds#GO:0016788;phosphatase binding#GO:0019902;phosphatase activity#GO:0016791;binding#GO:0005488;catalytic activity#GO:0003824;phosphatidylinositol-3,5-bisphosphate phosphatase activity#GO:0106018;hydrolase activity#GO:0016787;enzyme binding#GO:0019899;protein binding#GO:0005515;protein phosphatase binding#GO:0019903;phosphoric ester hydrolase activity#GO:0042578 lipid metabolic process#GO:0006629;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of catabolic process#GO:0009894;lipid modification#GO:0030258;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;glycerolipid metabolic process#GO:0046486;negative regulation of cellular process#GO:0048523;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;phospholipid dephosphorylation#GO:0046839;phosphatidylinositol dephosphorylation#GO:0046856;regulation of autophagy#GO:0010506;negative regulation of cellular catabolic process#GO:0031330;cellular metabolic process#GO:0044237;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;negative regulation of metabolic process#GO:0009892;regulation of cellular catabolic process#GO:0031329;negative regulation of autophagy#GO:0010507;cellular process#GO:0009987;primary metabolic process#GO:0044238;negative regulation of catabolic process#GO:0009895;regulation of cellular process#GO:0050794;dephosphorylation#GO:0016311;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG191581|UniProtKB=T1FT37 T1FT37 20211984 PTHR39074:SF1 AGAP007547-PA AGAP007547-PA HELRO|EnsemblGenome=HelroG79879|UniProtKB=T1G3U9 T1G3U9 20215747 PTHR11537:SF155 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 7 monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;delayed rectifier potassium channel activity#GO:0005251;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG62839|UniProtKB=T1FX58 T1FX58 20213406 PTHR10352:SF25 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G FOUND IN NEURONS, ISOFORM A-RELATED translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG186525|UniProtKB=T1FP06 T1FP06 20210553 PTHR13140:SF713 MYOSIN UNCONVENTIONAL MYOSIN ID microfilament motor activity#GO:0000146;cytoskeletal protein binding#GO:0008092;ATP-dependent activity#GO:0140657;binding#GO:0005488;actin filament binding#GO:0051015;cytoskeletal motor activity#GO:0003774;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779 actin filament-based movement#GO:0030048;transport#GO:0006810;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;establishment of localization#GO:0051234;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;import into cell#GO:0098657 microvillus#GO:0005902;actin-based cell projection#GO:0098858;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cell projection#GO:0042995;plasma membrane#GO:0005886 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG159241|UniProtKB=T1ENS4 T1ENS4 20198224 PTHR35578:SF6 PROLINE-RICH TRANSMEMBRANE PROTEIN 4-RELATED PROLINE-RICH TRANSMEMBRANE PROTEIN 4 HELRO|EnsemblGenome=HelroG65936|UniProtKB=T1FYE5 T1FYE5 20213843 PTHR46063:SF1 KELCH DOMAIN-CONTAINING PROTEIN KELCH DOMAIN-CONTAINING PROTEIN 4 HELRO|EnsemblGenome=HelroG186045|UniProtKB=T1FNL2 T1FNL2 20210409 PTHR45752:SF196 LEUCINE-RICH REPEAT-CONTAINING GH17740P scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG184082|UniProtKB=T1FKJ6 T1FKJ6 20209345 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158836|UniProtKB=T1ENB6 T1ENB6 20198066 PTHR22744:SF17 HELIX LOOP HELIX PROTEIN 21-RELATED BTB DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193239|UniProtKB=T1FUS2 T1FUS2 20212568 PTHR19932:SF10 WD REPEAT AND HMG-BOX DNA BINDING PROTEIN WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1 protein-containing complex binding#GO:0044877;binding#GO:0005488;chromatin binding#GO:0003682 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;mitotic cell cycle#GO:0000278;organic cyclic compound metabolic process#GO:1901360;response to stress#GO:0006950;nitrogen compound metabolic process#GO:0006807;DNA-templated DNA replication#GO:0006261;cell cycle#GO:0007049;DNA replication#GO:0006260;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;chromosome#GO:0005694;nuclear replication fork#GO:0043596;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;replication fork#GO:0005657 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG176328|UniProtKB=T1FAE3 T1FAE3 20205792 PTHR24256:SF470 TRYPTASE-RELATED INACTIVE CLIP DOMAIN-CONTAINING SERINE PROTEASE A30 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG172593|UniProtKB=T1F5K7 T1F5K7 20204106 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG83646|UniProtKB=T1G587 T1G587 20216234 PTHR12360:SF12 NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1 TRANSCRIPTIONAL REPRESSOR NF-X1 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG167056|UniProtKB=T1EYY6 T1EYY6 20201786 PTHR31214:SF2 PROTEIN FAM221A-RELATED PROTEIN FAM221A HELRO|EnsemblGenome=HelroG77476|UniProtKB=T1G2Y3 T1G2Y3 20215431 PTHR11920:SF501 GUANYLYL CYCLASE GUANYLATE CYCLASE 32E adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG156059|UniProtKB=T1ELR2 T1ELR2 20197512 PTHR11938:SF91 FAD NADPH DEHYDROGENASE/OXIDOREDUCTASE NADPH:ADRENODOXIN OXIDOREDUCTASE, MITOCHONDRIAL oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 oxidoreductase#PC00176 Vitamin D metabolism and pathway#P04396>FdxR#P04604 HELRO|EnsemblGenome=HelroG105298|UniProtKB=T1EDT5 T1EDT5 20194737 PTHR24390:SF242 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 76 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG175474|UniProtKB=T1F9A6 T1F9A6 20205405 PTHR13362:SF2 MITOCHONDRIAL RIBOSOMAL PROTEIN S33 SMALL RIBOSOMAL SUBUNIT PROTEIN MS33 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG177323|UniProtKB=T1FBH9 T1FBH9 20206178 PTHR42264:SF6 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE PROTEIN HELRO|EnsemblGenome=HelroG172606|UniProtKB=T1F5L9 T1F5L9 20204118 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG174304|UniProtKB=T1F7Z2 T1F7Z2 20204941 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG176487|UniProtKB=T1FAK5 T1FAK5 20205854 PTHR47827:SF3 AHD DOMAIN-CONTAINING PROTEIN AF-9 ANC1 HOMOLOGY DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;protein-containing complex binding#GO:0044877;histone binding#GO:0042393;binding#GO:0005488;chromatin binding#GO:0003682;modification-dependent protein binding#GO:0140030 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;transcription elongation factor complex#GO:0008023;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG163608|UniProtKB=T1EUA0 T1EUA0 20200150 PTHR10367:SF17 MRNA-CAPPING ENZYME MRNA-CAPPING ENZYME catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mRNA processing#GO:0006397;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 RNA processing factor#PC00147;RNA metabolism protein#PC00031;mRNA capping factor#PC00145 HELRO|EnsemblGenome=HelroG172035|UniProtKB=T1F4Z0 T1F4Z0 20203889 PTHR21669:SF28 CAPZ-INTERACTING PROTEIN AND RELATED PROTEINS YEMANUCLEIN cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;protein-DNA complex organization#GO:0071824;cellular component organization#GO:0016043;cellular process#GO:0009987;protein-containing complex organization#GO:0043933 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG193523|UniProtKB=T1FV28 T1FV28 20212674 PTHR19376:SF37 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;RNA polymerase activity#GO:0097747;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;RNA polymerase II activity#GO:0001055 membrane-enclosed lumen#GO:0031974;RNA polymerase II, core complex#GO:0005665;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase II, holoenzyme#GO:0016591;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG171047|UniProtKB=T1F3R0 T1F3R0 20203459 PTHR12751:SF18 PHOSPHATASE AND ACTIN REGULATOR PHACTR PHOSPHATASE AND ACTIN REGULATOR 1 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG99671|UniProtKB=T1G9U3 T1G9U3 20217839 PTHR10880:SF48 MORTALITY FACTOR 4-LIKE PROTEIN MORTALITY FACTOR 4 LIKE 2 histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;protein-DNA complex#GO:0032993;chromatin#GO:0000785;catalytic complex#GO:1902494;NuA4 histone acetyltransferase complex#GO:0035267;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;chromosome#GO:0005694 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG179717|UniProtKB=T1FF25 T1FF25 20207424 PTHR23196:SF1 PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN PAX-INTERACTING PROTEIN 1 HELRO|EnsemblGenome=HelroG177643|UniProtKB=T1FBZ9 T1FBZ9 20206348 PTHR22765:SF416 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE GODZILLA transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG194347|UniProtKB=T1FVY7 T1FVY7 20212983 PTHR11360:SF286 MONOCARBOXYLATE TRANSPORTER GH22266P transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;monocarboxylic acid transmembrane transporter activity#GO:0008028;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;monocarboxylic acid transport#GO:0015718;establishment of localization#GO:0051234;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942 transporter#PC00227 HELRO|EnsemblGenome=HelroG109762|UniProtKB=T1EEW3 T1EEW3 20195115 PTHR22599:SF21 MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB MOB KINASE ACTIVATOR 2 protein kinase activator activity#GO:0030295;protein kinase regulator activity#GO:0019887;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234;kinase activator activity#GO:0019209 positive regulation of nitrogen compound metabolic process#GO:0051173;signal transduction#GO:0007165;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;positive regulation of protein modification process#GO:0031401;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of metabolic process#GO:0009893;positive regulation of biological process#GO:0048518;signaling#GO:0023052;positive regulation of protein phosphorylation#GO:0001934;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;positive regulation of protein metabolic process#GO:0051247;positive regulation of phosphate metabolic process#GO:0045937;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of protein phosphorylation#GO:0001932;biological regulation#GO:0065007;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 kinase modulator#PC00140;kinase activator#PC00138 HELRO|EnsemblGenome=HelroG188214|UniProtKB=T1FPS3 T1FPS3 20210820 PTHR15065:SF4 INSULINOMA-ASSOCIATED 1 LD18634P HELRO|EnsemblGenome=HelroG161090|UniProtKB=T1ER34 T1ER34 20199034 PTHR46145:SF4 HEPARANASE HEPARANASE glycosidase#PC00110;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG81612|UniProtKB=T1G4G5 T1G4G5 20215963 PTHR11728:SF8 GLYCEROL-3-PHOSPHATE DEHYDROGENASE GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;carbohydrate derivative metabolic process#GO:1901135;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;pyridine nucleotide metabolic process#GO:0019362;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;glycerol-3-phosphate metabolic process#GO:0006072;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG175606|UniProtKB=T1F9F0 T1F9F0 20205449 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG127644|UniProtKB=T1EHG1 T1EHG1 20196011 PTHR23235:SF173 KRUEPPEL-LIKE TRANSCRIPTION FACTOR C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG70637|UniProtKB=T1G097 T1G097 20214495 PTHR24073:SF263 DRAB5-RELATED RAB-LIKE PROTEIN 2A-RELATED GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 localization#GO:0051179;organic substance transport#GO:0071702;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;protein transport#GO:0015031;nitrogen compound transport#GO:0071705;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG64397|UniProtKB=T1FXU2 T1FXU2 20213640 PTHR13140:SF857 MYOSIN MYOSIN-11 microfilament motor activity#GO:0000146;cytoskeletal protein binding#GO:0008092;ATP-dependent activity#GO:0140657;binding#GO:0005488;actin filament binding#GO:0051015;cytoskeletal motor activity#GO:0003774;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG84680|UniProtKB=T1G5L9 T1G5L9 20216366 PTHR23304:SF183 SPOT2-RELATED T. BRUCEI SPP.-SPECIFIC PROTEIN HELRO|EnsemblGenome=HelroG184165|UniProtKB=T1FKP6 T1FKP6 20209395 PTHR31395:SF26 SHISA STANLEY-CUP scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG76128|UniProtKB=T1G2F4 T1G2F4 20215252 PTHR10838:SF20 SYNAPTOGYRIN SYNAPTOGYRIN synaptic vesicle membrane#GO:0030672;bounding membrane of organelle#GO:0098588;presynapse#GO:0098793;synapse#GO:0045202;synaptic vesicle#GO:0008021;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;cell junction#GO:0030054;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;vesicle membrane#GO:0012506;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;transport vesicle membrane#GO:0030658;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;transport vesicle#GO:0030133;cytoplasmic vesicle membrane#GO:0030659;secretory vesicle#GO:0099503;neuromuscular junction#GO:0031594 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG192908|UniProtKB=T1FUF0 T1FUF0 20212446 PTHR46370:SF1 GPALPP MOTIFS-CONTAINING PROTEIN 1 GPALPP MOTIFS-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG62376|UniProtKB=T1FWZ9 T1FWZ9 20213347 PTHR21580:SF57 SHIPPO-1-RELATED OUTER DENSE FIBER OF SPERM TAILS 3-LIKE 2-RELATED intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 structural protein#PC00211 HELRO|EnsemblGenome=HelroG179721|UniProtKB=T1FF27 T1FF27 20207426 PTHR24041:SF32 MUCIN ANKYRIN REPEAT-CONTAINING PROTEIN cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG78857|UniProtKB=T1G3G4 T1G3G4 20215612 PTHR12893:SF0 GOLGI REASSEMBLY STACKING PROTEIN GRASP GRASP65 endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cellular process#GO:0009987;Golgi organization#GO:0007030;organelle organization#GO:0006996 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG176761|UniProtKB=T1FAW0 T1FAW0 20205959 PTHR46458:SF1 BLR2807 PROTEIN GEO09476P1 transporter#PC00227 HELRO|EnsemblGenome=HelroG161605|UniProtKB=T1ERP5 T1ERP5 20199245 PTHR24369:SF210 ANTIGEN BSP, PUTATIVE-RELATED CHAOPTIN-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG159618|UniProtKB=T1EP89 T1EP89 20198389 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG113789|UniProtKB=T1EFW5 T1EFW5 20195467 PTHR45920:SF4 FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;cortical cytoskeleton organization#GO:0030865;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;cortical actin cytoskeleton organization#GO:0030866 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG165250|UniProtKB=T1EWH9 T1EWH9 20200929 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG90895|UniProtKB=T1G7X6 T1G7X6 20217173 PTHR45638:SF11 CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A protein-containing complex binding#GO:0044877;binding#GO:0005488 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG158464|UniProtKB=T1EMT8 T1EMT8 20197888 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165749|UniProtKB=T1EX89 T1EX89 20201189 PTHR47027:SF20 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN HELRO|EnsemblGenome=HelroG194130|UniProtKB=T1FVQ3 T1FVQ3 20212899 PTHR10131:SF157 TNF RECEPTOR ASSOCIATED FACTOR RECEPTOR-ASSOCIATED FACTOR, PUTATIVE-RELATED regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;regulation of canonical NF-kappaB signal transduction#GO:0043122;regulation of signaling#GO:0023051;biological regulation#GO:0065007;regulation of intracellular signal transduction#GO:1902531 receptor complex#GO:0043235;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG182794|UniProtKB=T1FIR2 T1FIR2 20208711 PTHR46601:SF1 ULP_PROTEASE DOMAIN-CONTAINING PROTEIN ADF-H DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG62849|UniProtKB=T1FX62 T1FX62 20213410 PTHR11132:SF250 SOLUTE CARRIER FAMILY 35 SOLUTE CARRIER FAMILY 35 MEMBER E3 carbohydrate derivative transmembrane transporter activity#GO:1901505;secondary active transmembrane transporter activity#GO:0015291;antiporter activity#GO:0015297;transmembrane transporter activity#GO:0022857;nucleobase-containing compound transmembrane transporter activity#GO:0015932;nucleotide-sugar transmembrane transporter activity#GO:0005338;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215 localization#GO:0051179;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG193806|UniProtKB=T1FVD6 T1FVD6 20212782 PTHR23107:SF34 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN HTH LA-TYPE RNA-BINDING DOMAIN-CONTAINING PROTEIN transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG180659|UniProtKB=T1FG49 T1FG49 20207798 PTHR10634:SF149 AN1-TYPE ZINC FINGER PROTEIN AN1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG160702|UniProtKB=T1EQM4 T1EQM4 20198874 PTHR48138:SF2 KERATINOCYTE PROLINE-RICH PROTEIN-RELATED KERATINOCYTE PROLINE-RICH PROTEIN HELRO|EnsemblGenome=HelroG185598|UniProtKB=T1FN07 T1FN07 20210206 PTHR21240:SF27 2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE 2-AMINO-3-CARBOXYMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE secondary metabolic process#GO:0019748;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 decarboxylase#PC00089;lyase#PC00144 HELRO|EnsemblGenome=HelroG157626|UniProtKB=T1EME1 T1EME1 20197741 PTHR45986:SF1 ZINC FINGER MATRIN-TYPE PROTEIN 2 ZINC FINGER MATRIN-TYPE PROTEIN 2 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;spliceosomal tri-snRNP complex#GO:0097526;U4/U6 x U5 tri-snRNP complex#GO:0046540;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG179247|UniProtKB=T1FEF4 T1FEF4 20207203 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG176818|UniProtKB=T1FAX9 T1FAX9 20205978 PTHR11785:SF516 AMINO ACID TRANSPORTER AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN L-amino acid transmembrane transporter activity#GO:0015179;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;amino acid transport#GO:0006865;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;nitrogen compound transport#GO:0071705;organic acid transmembrane transport#GO:1903825;carboxylic acid transport#GO:0046942;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039 transporter#PC00227 HELRO|EnsemblGenome=HelroG94727|UniProtKB=T1G925 T1G925 20217572 PTHR46492:SF1 DYNEIN ASSEMBLY FACTOR 4, AXONEMAL DYNEIN AXONEMAL ASSEMBLY FACTOR 4 cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;outer dynein arm assembly#GO:0036158;cell projection organization#GO:0030030;inner dynein arm assembly#GO:0036159;protein-containing complex assembly#GO:0065003;microtubule-based movement#GO:0007018;microtubule cytoskeleton organization#GO:0000226;cellular component organization#GO:0016043;axoneme assembly#GO:0035082;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;cilium movement#GO:0003341;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection assembly#GO:0120031 chaperone#PC00072 HELRO|EnsemblGenome=HelroG159775|UniProtKB=T1EPE2 T1EPE2 20198442 PTHR34349:SF1 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 32 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 32 phosphatase binding#GO:0019902;enzyme binding#GO:0019899;protein binding#GO:0005515;binding#GO:0005488 protein-binding activity modulator#PC00095;phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG178958|UniProtKB=T1FDY8 T1FDY8 20207037 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG157041|UniProtKB=T1EM53 T1EM53 20197653 PTHR11994:SF8 60S RIBOSOMAL PROTEIN L11-RELATED 60S RIBOSOMAL PROTEIN L11 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG66532|UniProtKB=T1FYM5 T1FYM5 20213923 PTHR46367:SF1 ATAXIN-7-LIKE PROTEIN 3 ATAXIN-7-LIKE PROTEIN 3 transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 SAGA-type complex#GO:0070461;peptidase complex#GO:1905368;histone acetyltransferase complex#GO:0000123;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;acetyltransferase complex#GO:1902493;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;chromosome#GO:0005694;SAGA complex#GO:0000124;membrane-bounded organelle#GO:0043227;DUBm complex#GO:0071819;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG182652|UniProtKB=T1FIJ5 T1FIJ5 20208644 PTHR37162:SF1 HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED BED-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178696|UniProtKB=T1FDL0 T1FDL0 20206909 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG88092|UniProtKB=T1G6Y3 T1G6Y3 20216830 PTHR15440:SF0 XRP2 PROTEIN PROTEIN XRP2 nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;Golgi vesicle transport#GO:0048193;post-Golgi vesicle-mediated transport#GO:0006892;transport#GO:0006810 membrane-bounded organelle#GO:0043227;plasma membrane region#GO:0098590;cell projection#GO:0042995;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;cilium#GO:0005929;organelle#GO:0043226;plasma membrane#GO:0005886 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG80629|UniProtKB=T1G430 T1G430 20215828 PTHR46365:SF1 COPPER TRANSPORT PROTEIN ATOX1 COPPER TRANSPORT PROTEIN ATOX1 localization#GO:0051179;monoatomic cation transport#GO:0006812;transition metal ion transport#GO:0000041;metal ion transport#GO:0030001;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG92246|UniProtKB=T1G8D5 T1G8D5 20217332 PTHR45832:SF22 SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED HELRO|EnsemblGenome=HelroG144002|UniProtKB=T1EJD3 T1EJD3 20196683 PTHR48043:SF145 EG:EG0003.4 PROTEIN-RELATED FI06409P-RELATED HELRO|EnsemblGenome=HelroG66280|UniProtKB=T1FYJ0 T1FYJ0 20213888 PTHR12549:SF38 JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN JMJC DOMAIN-CONTAINING HISTONE DEMETHYLASE 2, ISOFORM A histone modifying activity#GO:0140993;nucleic acid binding#GO:0003676;histone demethylase activity#GO:0032452;binding#GO:0005488;catalytic activity#GO:0003824;protein-macromolecule adaptor activity#GO:0030674;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;demethylase activity#GO:0032451;molecular adaptor activity#GO:0060090;chromatin DNA binding#GO:0031490;chromatin binding#GO:0003682;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;protein-containing complex binding#GO:0044877;catalytic activity, acting on a protein#GO:0140096 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;histone deacetylase complex#GO:0000118;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG169169|UniProtKB=T1F1I7 T1F1I7 20202687 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG90362|UniProtKB=T1G7P8 T1G7P8 20217095 PTHR10934:SF2 60S RIBOSOMAL PROTEIN L18 LARGE RIBOSOMAL SUBUNIT PROTEIN EL18 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG107863|UniProtKB=T1EED4 T1EED4 20194936 PTHR11071:SF561 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;catalytic activity#GO:0003824;peptide binding#GO:0042277;amide binding#GO:0033218 macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein peptidyl-prolyl isomerization#GO:0000413;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG93614|UniProtKB=T1G8W9 T1G8W9 20217516 PTHR46041:SF2 MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2 MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2 hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular localization#GO:0051641;mitochondrial protein processing#GO:0034982;macromolecule localization#GO:0033036;gene expression#GO:0010467;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;protein processing#GO:0016485;establishment of localization#GO:0051234;protein targeting to mitochondrion#GO:0006626;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein localization to organelle#GO:0033365;protein metabolic process#GO:0019538;protein processing involved in protein targeting to mitochondrion#GO:0006627;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein targeting#GO:0006605;cellular metabolic process#GO:0044237;establishment of protein localization to organelle#GO:0072594;protein maturation#GO:0051604;organonitrogen compound metabolic process#GO:1901564;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein localization to mitochondrion#GO:0070585;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;cellular macromolecule localization#GO:0070727;establishment of protein localization to mitochondrion#GO:0072655 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;mitochondrial protein-containing complex#GO:0098798 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191771|UniProtKB=T1FTA9 T1FTA9 20212056 PTHR12983:SF9 RING FINGER 10 FAMILY MEMBER E3 UBIQUITIN-PROTEIN LIGASE RNF10 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 HELRO|EnsemblGenome=HelroG159828|UniProtKB=T1EPG1 T1EPG1 20198461 PTHR19325:SF575 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING LOCOMOTION-RELATED PROTEIN HIKARU GENKI complement component#PC00078 HELRO|EnsemblGenome=HelroG160147|UniProtKB=T1EPV9 T1EPV9 20209551 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG103835|UniProtKB=T1EDH8 T1EDH8 20194630 PTHR43381:SF4 TRANSLATION INITIATION FACTOR IF-2-RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 5B nucleic acid binding#GO:0003676;translation regulator activity#GO:0045182;translation regulator activity, nucleic acid binding#GO:0090079;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation initiation factor activity#GO:0003743;translation factor activity, RNA binding#GO:0008135 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;translational initiation#GO:0006413;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG166233|UniProtKB=T1EXX5 T1EXX5 20201425 PTHR22776:SF49 MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN MARVEL DOMAIN-CONTAINING PROTEIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG189327|UniProtKB=T1FQY6 T1FQY6 20211233 PTHR38537:SF8 JITTERBUG, ISOFORM N FILAMIN-A HELRO|EnsemblGenome=HelroG87445|UniProtKB=T1G6Q2 T1G6Q2 20216749 PTHR46010:SF1 PROTEIN IWS1 HOMOLOG PROTEIN IWS1 HOMOLOG poly(A)+ mRNA export from nucleus#GO:0016973;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;mRNA transport#GO:0051028;RNA localization#GO:0006403;localization#GO:0051179;organic substance transport#GO:0071702;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG181343|UniProtKB=T1FGX0 T1FGX0 20208069 PTHR10829:SF25 CORTACTIN AND DREBRIN DREBRIN-LIKE PROTEIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 regulation of anatomical structure size#GO:0090066;regulation of actin filament length#GO:0030832;regulation of organelle organization#GO:0033043;regulation of actin filament organization#GO:0110053;regulation of cellular component organization#GO:0051128;cellular component organization#GO:0016043;regulation of actin polymerization or depolymerization#GO:0008064;cellular process#GO:0009987;regulation of actin filament polymerization#GO:0030833;regulation of cellular component size#GO:0032535;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cytoskeleton organization#GO:0051493;regulation of protein-containing complex assembly#GO:0043254;regulation of biological quality#GO:0065008;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament-based process#GO:0032970;regulation of protein polymerization#GO:0032271 supramolecular complex#GO:0099080;cortical cytoskeleton#GO:0030863;supramolecular polymer#GO:0099081;cellular anatomical entity#GO:0110165;cell cortex#GO:0005938;cell periphery#GO:0071944;supramolecular fiber#GO:0099512;cortical actin cytoskeleton#GO:0030864;organelle#GO:0043226;actin filament#GO:0005884;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG170366|UniProtKB=T1F2Z1 T1F2Z1 20203190 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG114428|UniProtKB=T1EG16 T1EG16 20195518 PTHR11085:SF6 NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2 nucleotide binding#GO:0000166;histone modifying activity#GO:0140993;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;deacetylase activity#GO:0019213;histone deacetylase activity#GO:0004407;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168;catalytic activity, acting on a protein#GO:0140096 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG177514|UniProtKB=T1FBT9 T1FBT9 20206288 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG155693|UniProtKB=T1ELK7 T1ELK7 20197457 PTHR11274:SF0 RAD25/XP-B DNA REPAIR HELICASE GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB DNA metabolism protein#PC00009;DNA helicase#PC00011 HELRO|EnsemblGenome=HelroG62917|UniProtKB=T1FX75 T1FX75 20213423 PTHR46161:SF1 NUCLEOSIDE DIPHOSPHATE KINASE NUCLEOSIDE DIPHOSPHATE KINASE HOMOLOG 5 nucleotide kinase#PC00172 De novo purine biosynthesis#P02738>dADP kinase#P02907;De novo purine biosynthesis#P02738>GDP kinase#P02891 HELRO|EnsemblGenome=HelroG187713|UniProtKB=T1FPC2 T1FPC2 20210669 PTHR12918:SF1 CYSTEINE DIOXYGENASE CYSTEINE DIOXYGENASE TYPE 1 cation binding#GO:0043169;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;ferrous iron binding#GO:0008198;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;iron ion binding#GO:0005506;dioxygenase activity#GO:0051213;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;ion binding#GO:0043167;oxidoreductase activity#GO:0016491 oxygenase#PC00177;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG188488|UniProtKB=T1FQ17 T1FQ17 20210914 PTHR33091:SF29 PROTEIN, PUTATIVE, EXPRESSED-RELATED SUBTILISIN INHIBITOR 1 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG156421|UniProtKB=T1ELW0 T1ELW0 20197560 PTHR12209:SF0 NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE EKC_KEOPS COMPLEX SUBUNIT TP53RK transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG190530|UniProtKB=T1FS28 T1FS28 20211625 PTHR14527:SF2 PROTEIN MIS12 HOMOLOG PROTEIN MIS12 HOMOLOG cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;nuclear chromosome segregation#GO:0098813;protein-DNA complex organization#GO:0071824;kinetochore organization#GO:0051383;sister chromatid segregation#GO:0000819;nuclear division#GO:0000280;cell cycle process#GO:0022402;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;protein-DNA complex assembly#GO:0065004;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047;chromosome segregation#GO:0007059;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;organelle organization#GO:0006996;chromosome organization#GO:0051276;protein-containing complex organization#GO:0043933;cell cycle#GO:0007049;mitotic nuclear division#GO:0140014;organelle fission#GO:0048285;mitotic sister chromatid segregation#GO:0000070;kinetochore assembly#GO:0051382;non-membrane-bounded organelle assembly#GO:0140694 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;non-membrane-bounded organelle#GO:0043228;outer kinetochore#GO:0000940;protein-containing complex#GO:0032991;kinetochore#GO:0000776;chromosome#GO:0005694;condensed chromosome, centromeric region#GO:0000779;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;chromosomal region#GO:0098687;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG65527|UniProtKB=T1FY90 T1FY90 20213788 PTHR43920:SF5 CHLORIDE INTRACELLULAR CHANNEL, ISOFORM A CHLORIDE INTRACELLULAR CHANNEL CLIC inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216 localization#GO:0051179;chloride transport#GO:0006821;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;inorganic anion transport#GO:0015698;monoatomic anion transport#GO:0006820;transport#GO:0006810 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG185291|UniProtKB=T1FMM2 T1FMM2 20210071 PTHR14119:SF3 HYDROLASE ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG171028|UniProtKB=T1F3Q4 T1F3Q4 20203453 PTHR21043:SF0 IOJAP SUPERFAMILY ORTHOLOG MITOCHONDRIAL ASSEMBLY OF RIBOSOMAL LARGE SUBUNIT PROTEIN 1 ribonucleoprotein complex binding#GO:0043021;ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877;binding#GO:0005488 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of protein metabolic process#GO:0051246;negative regulation of biosynthetic process#GO:0009890;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of translation#GO:0017148;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 HELRO|EnsemblGenome=HelroG105243|UniProtKB=T1EDS0 T1EDS0 20194722 PTHR14255:SF4 CEREBLON PROTEIN CEREBLON protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234;Cul4-RING E3 ubiquitin ligase complex#GO:0080008 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG182534|UniProtKB=T1FIB7 T1FIB7 20208566 PTHR19282:SF549 TETRASPANIN TETRASPANIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG178116|UniProtKB=T1FCR6 T1FCR6 20206615 PTHR48033:SF17 RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN RRM DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG189331|UniProtKB=T1FQY9 T1FQY9 20211236 PTHR11533:SF301 PROTEASE M1 ZINC METALLOPROTEASE AMINOPEPTIDASE metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;amide binding#GO:0033218;metal ion binding#GO:0046872;peptidase activity#GO:0008233;metalloaminopeptidase activity#GO:0070006;cation binding#GO:0043169;peptide binding#GO:0042277;hydrolase activity#GO:0016787;aminopeptidase activity#GO:0004177;exopeptidase activity#GO:0008238;ion binding#GO:0043167;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;peptide catabolic process#GO:0043171;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;membrane#GO:0016020;extracellular region#GO:0005576;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG110454|UniProtKB=T1EF22 T1EF22 20195174 PTHR22884:SF498 SET DOMAIN PROTEINS HISTONE-LYSINE N-METHYLTRANSFERASE ASHH3 N-methyltransferase activity#GO:0008170;histone modifying activity#GO:0140993;transferase activity#GO:0016740;catalytic activity#GO:0003824;histone methyltransferase activity#GO:0042054;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;protein-lysine N-methyltransferase activity#GO:0016279;catalytic activity, acting on a protein#GO:0140096;lysine N-methyltransferase activity#GO:0016278;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein methyltransferase activity#GO:0008276 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG168599|UniProtKB=T1F0S2 T1F0S2 20202422 PTHR23121:SF9 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 transmembrane transporter activity#GO:0022857;sugar transmembrane transporter activity#GO:0051119;transporter activity#GO:0005215;carbohydrate transmembrane transporter activity#GO:0015144 transporter#PC00227 HELRO|EnsemblGenome=HelroG177447|UniProtKB=T1FBQ2 T1FBQ2 20206251 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193594|UniProtKB=T1FV55 T1FV55 20212701 PTHR46448:SF1 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN PROTEIN KINASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG160226|UniProtKB=T1EPZ9 T1EPZ9 20198649 PTHR32343:SF22 SERINE/ARGININE-RICH SPLICING FACTOR LD29830P RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG72771|UniProtKB=T1G154 T1G154 20214802 PTHR28672:SF1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 13 ANAPHASE-PROMOTING COMPLEX SUBUNIT 13 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;protein K11-linked ubiquitination#GO:0070979;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234;anaphase-promoting complex#GO:0005680;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear ubiquitin ligase complex#GO:0000152;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG188015|UniProtKB=T1FPJ8 T1FPJ8 20210745 PTHR12958:SF3 FRIEND OF GATA2-RELATED ZINC FINGER PROTEIN USH positive regulation of nitrogen compound metabolic process#GO:0051173;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;heart development#GO:0007507;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of RNA metabolic process#GO:0051253;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;animal organ development#GO:0048513;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;system development#GO:0048731;cell differentiation#GO:0030154;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of transcription by RNA polymerase II#GO:0000122;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;cellular developmental process#GO:0048869;circulatory system development#GO:0072359;negative regulation of biosynthetic process#GO:0009890;regulation of DNA-templated transcription#GO:0006355;multicellular organism development#GO:0007275;negative regulation of metabolic process#GO:0009892;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;negative regulation of nitrogen compound metabolic process#GO:0051172;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;anatomical structure development#GO:0048856;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG90755|UniProtKB=T1G7V8 T1G7V8 20217155 PTHR10682:SF10 POLY A POLYMERASE POLYNUCLEOTIDE ADENYLYLTRANSFERASE adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;mRNA polyadenylation#GO:0006378;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;mRNA 3'-end processing#GO:0031124;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mRNA processing#GO:0006397;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG65589|UniProtKB=T1FYA3 T1FYA3 20213801 PTHR13027:SF7 SAND PROTEIN-RELATED VACUOLAR FUSION PROTEIN MON1 HOMOLOG HELRO|EnsemblGenome=HelroG65985|UniProtKB=T1FYF6 T1FYF6 20213854 PTHR23279:SF36 DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED DEFECTIVE PROBOSCIS EXTENSION RESPONSE 9, ISOFORM A cellular component organization or biogenesis#GO:0071840;synapse organization#GO:0050808;cellular component organization#GO:0016043;cellular process#GO:0009987;cell junction organization#GO:0034330 cell leading edge#GO:0031252;neuron projection#GO:0043005;leading edge membrane#GO:0031256;plasma membrane region#GO:0098590;cell projection membrane#GO:0031253;cell projection#GO:0042995;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG159432|UniProtKB=T1EP11 T1EP11 20198311 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG66888|UniProtKB=T1FYS5 T1FYS5 20213973 PTHR11085:SF9 NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1 nucleotide binding#GO:0000166;histone modifying activity#GO:0140993;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;deacetylase activity#GO:0019213;histone deacetylase activity#GO:0004407;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168;catalytic activity, acting on a protein#GO:0140096 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 p53 pathway#P00059>SIRT-1#P04632 HELRO|EnsemblGenome=HelroG186194|UniProtKB=T1FNS9 T1FNS9 20210476 PTHR21539:SF0 SAGA-ASSOCIATED FACTOR 29 SAGA-ASSOCIATED FACTOR 29 protein binding#GO:0005515;methylated histone binding#GO:0035064;binding#GO:0005488;histone binding#GO:0042393;modification-dependent protein binding#GO:0140030 SAGA-type complex#GO:0070461;peptidase complex#GO:1905368;histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;protein-DNA complex#GO:0032993;chromatin#GO:0000785;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;chromosome#GO:0005694;SAGA complex#GO:0000124 HELRO|EnsemblGenome=HelroG67947|UniProtKB=T1FZ82 T1FZ82 20214130 PTHR24351:SF228 RIBOSOMAL PROTEIN S6 KINASE PROTEIN KINASE C transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG69350|UniProtKB=T1FZT8 T1FZT8 20214336 PTHR10639:SF7 CLATHRIN LIGHT CHAIN CLATHRIN LIGHT CHAIN protein binding#GO:0005515;clathrin binding#GO:0030276;binding#GO:0005488 localization#GO:0051179;establishment of localization#GO:0051234;clathrin-dependent endocytosis#GO:0072583;transport#GO:0006810;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;receptor-mediated endocytosis#GO:0006898;cellular process#GO:0009987;import into cell#GO:0098657 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;clathrin vesicle coat#GO:0030125;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;vesicle coat#GO:0030120;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;clathrin-coated vesicle#GO:0030136;membrane coat#GO:0030117;coated vesicle membrane#GO:0030662;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;coated membrane#GO:0048475;cytoplasmic vesicle membrane#GO:0030659;plasma membrane#GO:0005886 vesicle coat protein#PC00235 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Clathrin#P00738;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Clathrin#P00722;Huntington disease#P00029>Clathrin#P00798 HELRO|EnsemblGenome=HelroG111253|UniProtKB=T1EF99 T1EF99 20195251 PTHR10027:SF10 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN SLOWPOKE 2, ISOFORM D monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;potassium ion transmembrane transporter activity#GO:0015079;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267 localization#GO:0051179;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG177819|UniProtKB=T1FCB6 T1FCB6 20206465 PTHR24020:SF20 COLLAGEN ALPHA PH DOMAIN-CONTAINING PROTEIN extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG84014|UniProtKB=T1G5D3 T1G5D3 20216280 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG66720|UniProtKB=T1FYP2 T1FYP2 20213940 PTHR10032:SF271 ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS RH12261P-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG188031|UniProtKB=T1FPK4 T1FPK4 20210751 PTHR23101:SF104 RAB GDP/GTP EXCHANGE FACTOR PROTEIN SPRINT nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;binding#GO:0005488;molecular function regulator activity#GO:0098772;enzyme binding#GO:0019899;protein binding#GO:0005515;small GTPase binding#GO:0031267;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;endocytic vesicle#GO:0030139;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG165384|UniProtKB=T1EWP4 T1EWP4 20200994 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG165911|UniProtKB=T1EXF9 T1EXF9 20201259 PTHR10947:SF3 PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47 catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG182684|UniProtKB=T1FIK9 T1FIK9 20208658 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG92478|UniProtKB=T1G8H0 T1G8H0 20217367 PTHR45721:SF12 LAMIN DM0-RELATED INTERMEDIATE FILAMENT PROTEIN IFA-1 structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;nuclear migration#GO:0007097;cellular localization#GO:0051641;negative regulation of biological process#GO:0048519;protein-DNA complex organization#GO:0071824;organelle localization#GO:0051640;macromolecule localization#GO:0033036;membrane organization#GO:0061024;transport#GO:0006810;protein localization to nucleus#GO:0034504;nucleus organization#GO:0006997;endomembrane system organization#GO:0010256;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;protein localization to organelle#GO:0033365;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;establishment of organelle localization#GO:0051656;negative regulation of cellular process#GO:0048523;localization within membrane#GO:0051668;negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;cellular process#GO:0009987;negative regulation of gene expression, epigenetic#GO:0045814;epigenetic regulation of gene expression#GO:0040029;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular macromolecule localization#GO:0070727;heterochromatin organization#GO:0070828;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;chromatin organization#GO:0006325;intracellular transport#GO:0046907;nuclear envelope organization#GO:0006998;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323;protein-containing complex localization#GO:0031503 membrane-enclosed lumen#GO:0031974;envelope#GO:0031975;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;nuclear periphery#GO:0034399;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981 HELRO|EnsemblGenome=HelroG169805|UniProtKB=T1F2C3 T1F2C3 20202973 PTHR16021:SF23 MANSC DOMAIN CONTAINING PROTEIN 1 FI18411P1-RELATED HELRO|EnsemblGenome=HelroG145957|UniProtKB=T1EJP3 T1EJP3 20196793 PTHR22883:SF301 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC12 palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular localization#GO:0051641;macromolecule localization#GO:0033036;macromolecule modification#GO:0043412;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;protein palmitoylation#GO:0018345;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;localization within membrane#GO:0051668;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein localization to membrane#GO:0072657;organonitrogen compound biosynthetic process#GO:1901566;protein targeting#GO:0006605;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;protein acylation#GO:0043543;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipoprotein biosynthetic process#GO:0042158;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;lipoprotein metabolic process#GO:0042157 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG187061|UniProtKB=T1FP65 T1FP65 20210612 PTHR44147:SF2 DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 1 DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 1 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG182082|UniProtKB=T1FHP6 T1FHP6 20208345 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG67698|UniProtKB=T1FZ41 T1FZ41 20214089 PTHR11711:SF21 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 6 carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167 cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;cilium assembly#GO:0060271;cell projection organization#GO:0030030;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;establishment of protein localization#GO:0045184;cell projection assembly#GO:0030031;protein localization#GO:0008104;localization#GO:0051179;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;protein localization to cilium#GO:0061512;establishment of localization#GO:0051234;organelle organization#GO:0006996;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365;plasma membrane bounded cell projection assembly#GO:0120031 axoneme#GO:0005930;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;plasma membrane bounded cell projection cytoplasm#GO:0032838;membrane-bounded organelle#GO:0043227;ciliary plasm#GO:0097014;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929 G-protein#PC00020 HELRO|EnsemblGenome=HelroG174641|UniProtKB=T1F8C1 T1F8C1 20205070 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG90722|UniProtKB=T1G7V0 T1G7V0 20217147 PTHR12778:SF10 SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 3 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG171680|UniProtKB=T1F4J6 T1F4J6 20203745 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG73143|UniProtKB=T1G1A8 T1G1A8 20214856 PTHR23122:SF72 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK GUANYLATE KINASE-LIKE DOMAIN-CONTAINING PROTEIN cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;cell-cell junction#GO:0005911;anchoring junction#GO:0070161;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG192049|UniProtKB=T1FTJ5 T1FTJ5 20212142 PTHR13681:SF24 SURVIVAL OF MOTOR NEURON-RELATED-SPLICING FACTOR 30-RELATED TUDOR DOMAIN-CONTAINING PROTEIN 3 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG185810|UniProtKB=T1FNB6 T1FNB6 20210313 PTHR10827:SF52 RETICULOCALBIN IP16409P cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG101345|UniProtKB=T1ED41 T1ED41 20194494 PTHR43715:SF1 GDP-MANNOSE 4,6-DEHYDRATASE GDP-MANNOSE 4,6 DEHYDRATASE dehydratase#PC00091;lyase#PC00144 Mannose metabolism#P02752>GDP-Mannose 4,6-dehydratase#P03015 HELRO|EnsemblGenome=HelroG159110|UniProtKB=T1ENL9 T1ENL9 20198169 PTHR10265:SF45 CYCLIN-DEPENDENT KINASE INHIBITOR 1 DACAPO kinase inhibitor#PC00139 HELRO|EnsemblGenome=HelroG101835|UniProtKB=T1ED72 T1ED72 20194524 PTHR48013:SF15 DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;MAPK cascade#GO:0000165;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Integrin signalling pathway#P00034>Jnk#P00951;FAS signaling pathway#P00020>MKK4#P00610;p38 MAPK pathway#P05918>MKK4#P06034;Huntington disease#P00029>MAPKK4#P00787;Ras Pathway#P04393>MKK4/7#P04565;Gonadotropin-releasing hormone receptor pathway#P06664>MKK4/7#P06760;Huntington disease#P00029>SEK-1#P00792;Apoptosis signaling pathway#P00006>SEK1#P00266;Angiogenesis#P00005>JNKK1#P00199;Toll receptor signaling pathway#P00054>MKK4#P01366;FGF signaling pathway#P00021>MKK4,7#P00637;Integrin signalling pathway#P00034>MEK#P00925;EGF receptor signaling pathway#P00018>MKK4,7#P00555;Oxidative stress response#P00046>MKK4#P01138;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>MEK#P00891 HELRO|EnsemblGenome=HelroG162756|UniProtKB=T1ET34 T1ET34 20199734 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170747|UniProtKB=T1F3D9 T1F3D9 20203338 PTHR24243:SF233 G-PROTEIN COUPLED RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG169864|UniProtKB=T1F2E1 T1F2E1 20202991 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG164675|UniProtKB=T1EVP8 T1EVP8 20200648 PTHR15654:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 113-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN 96 organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 axoneme#GO:0005930;microtubule organizing center#GO:0005815;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;ciliary plasm#GO:0097014;plasma membrane bounded cell projection cytoplasm#GO:0032838;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG62740|UniProtKB=T1FX44 T1FX44 20213392 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG188099|UniProtKB=T1FPM8 T1FPM8 20210775 PTHR12231:SF253 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG191636|UniProtKB=T1FT56 T1FT56 20212003 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG191259|UniProtKB=T1FST3 T1FST3 20211880 PTHR11849:SF304 ETS DNA-BINDING PROTEIN D-ETS-3 transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG187611|UniProtKB=T1FPB0 T1FPB0 20210657 PTHR24247:SF241 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE RECEPTOR 2A-RELATED signaling receptor activity#GO:0038023;G protein-coupled amine receptor activity#GO:0008227;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission#GO:0007268;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;synaptic signaling#GO:0099536;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;cell-cell signaling#GO:0007267 somatodendritic compartment#GO:0036477;neuron projection#GO:0043005;dendrite#GO:0030425;cell periphery#GO:0071944;dendritic tree#GO:0097447;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 5HT2 type receptor mediated signaling pathway#P04374>5HT2 Receptor#P04414;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720 HELRO|EnsemblGenome=HelroG180908|UniProtKB=T1FGE5 T1FGE5 20207894 PTHR47763:SF1 ALPHA-PROTEIN KINASE VWKA DUF659 DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-serine modification#GO:0018209;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG188959|UniProtKB=T1FQI2 T1FQI2 20211079 PTHR46512:SF1 PEPTIDYLPROLYL ISOMERASE PEPTIDYLPROLYL ISOMERASE negative regulation of biological process#GO:0048519;macromolecule biosynthetic process#GO:0009059;regulation of apoptotic process#GO:0042981;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;negative regulation of apoptotic process#GO:0043066;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;negative regulation of programmed cell death#GO:0043069;protein folding#GO:0006457;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;protein metabolic process#GO:0019538;negative regulation of cellular process#GO:0048523;organic substance metabolic process#GO:0071704;regulation of programmed cell death#GO:0043067;metabolic process#GO:0008152 envelope#GO:0031975;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG152497|UniProtKB=T1EKS2 T1EKS2 20197172 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG188308|UniProtKB=T1FPU9 T1FPU9 20210846 PTHR24058:SF17 DUAL SPECIFICITY PROTEIN KINASE HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;peptidyl-threonine phosphorylation#GO:0018107;nitrogen compound metabolic process#GO:0006807;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG179343|UniProtKB=T1FEK8 T1FEK8 20207257 PTHR23316:SF87 IMPORTIN ALPHA IMPORTIN SUBUNIT ALPHA signal sequence binding#GO:0005048;binding#GO:0005488;amide binding#GO:0033218;peptide binding#GO:0042277 cellular localization#GO:0051641;NLS-bearing protein import into nucleus#GO:0006607;macromolecule localization#GO:0033036;transport#GO:0006810;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;protein import into nucleus#GO:0006606;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365;nuclear transport#GO:0051169;import into nucleus#GO:0051170 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG73673|UniProtKB=T1G1H1 T1G1H1 20214919 PTHR24393:SF138 ZINC FINGER PROTEIN IP01201P-RELATED DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG165704|UniProtKB=T1EX70 T1EX70 20201170 PTHR21580:SF28 SHIPPO-1-RELATED BOREALIN N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED structural protein#PC00211 HELRO|EnsemblGenome=HelroG102781|UniProtKB=T1EDB7 T1EDB7 20194569 PTHR23088:SF27 NITRILASE-RELATED DEAMINATED GLUTATHIONE AMIDASE metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG167921|UniProtKB=T1EZY7 T1EZY7 20202137 PTHR21689:SF2 LIN-9 PROTEIN LIN-9 HOMOLOG nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG161790|UniProtKB=T1ERX1 T1ERX1 20199321 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG172987|UniProtKB=T1F690 T1F690 20204339 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193494|UniProtKB=T1FV19 T1FV19 20212665 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG177493|UniProtKB=T1FBS5 T1FBS5 20206274 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165642|UniProtKB=T1EX42 T1EX42 20201142 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG163550|UniProtKB=T1EU70 T1EU70 20200120 PTHR45762:SF3 ZINC FINGER RNA-BINDING PROTEIN ZINC-FINGER PROTEIN AT 72D, ISOFORM B RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG160388|UniProtKB=T1EQ70 T1EQ70 20198720 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168046|UniProtKB=T1F039 T1F039 20202189 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG97843|UniProtKB=T1G9J3 T1G9J3 20217739 PTHR43763:SF6 XAA-PRO AMINOPEPTIDASE 1 XAA-PRO AMINOPEPTIDASE 1 protease#PC00190 HELRO|EnsemblGenome=HelroG82552|UniProtKB=T1G4T9 T1G4T9 20216087 PTHR24340:SF41 HOMEOBOX PROTEIN NKX MUSCLE-SPECIFIC HOMEOBOX PROTEIN TINMAN-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG181659|UniProtKB=T1FH76 T1FH76 20208175 PTHR24229:SF40 NEUROPEPTIDES RECEPTOR ALLATOSTATIN C RECEPTOR 1-RELATED G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HELRO|EnsemblGenome=HelroG180052|UniProtKB=T1FFE6 T1FFE6 20207545 PTHR11412:SF136 MACROGLOBULIN / COMPLEMENT CD109 ANTIGEN protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG178316|UniProtKB=T1FD26 T1FD26 20206725 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED BRCT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG149301|UniProtKB=T1EKC5 T1EKC5 20197025 PTHR22455:SF10 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 91 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 91 HELRO|EnsemblGenome=HelroG186940|UniProtKB=T1FP45 T1FP45 20210592 PTHR24418:SF373 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE SRC42A protein tyrosine kinase activity#GO:0004713;non-membrane spanning protein tyrosine kinase activity#GO:0004715;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein binding#GO:0005515;catalytic activity, acting on a protein#GO:0140096;signaling receptor binding#GO:0005102;kinase activity#GO:0016301;protein kinase activity#GO:0004672 response to external biotic stimulus#GO:0043207;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;immune response#GO:0006955;developmental process#GO:0032502;cell communication#GO:0007154;cellular process#GO:0009987;defense response to symbiont#GO:0140546;regulation of biological process#GO:0050789;immune system process#GO:0002376;response to stimulus#GO:0050896;response to external stimulus#GO:0009605;cell differentiation#GO:0030154;enzyme-linked receptor protein signaling pathway#GO:0007167;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to other organism#GO:0098542;regulation of cellular process#GO:0050794;response to other organism#GO:0051707;cell surface receptor signaling pathway#GO:0007166;biological process involved in interspecies interaction between organisms#GO:0044419;biological regulation#GO:0065007;innate immune response#GO:0045087;defense response#GO:0006952;signaling#GO:0023052;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169 non-receptor tyrosine protein kinase#PC00168 Parkinson disease#P00049>Src kinase#P01230;Integrin signalling pathway#P00034>Src#P00940 HELRO|EnsemblGenome=HelroG94411|UniProtKB=T1G909 T1G909 20217556 PTHR13017:SF0 5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE-RELATED METHENYLTETRAHYDROFOLATE SYNTHASE DOMAIN-CONTAINING PROTEIN cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ligase#PC00142 HELRO|EnsemblGenome=HelroG174237|UniProtKB=T1F7U8 T1F7U8 20204897 PTHR36191:SF1 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188801|UniProtKB=T1FQD6 T1FQD6 20211033 PTHR10589:SF28 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE BAP1 cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG192806|UniProtKB=T1FUB4 T1FUB4 20212410 PTHR22765:SF434 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING GB|AAD18119.1-RELATED transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG181317|UniProtKB=T1FGW1 T1FGW1 20208060 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG96929|UniProtKB=T1G9E4 T1G9E4 20217691 PTHR24302:SF15 CYTOCHROME P450 FAMILY 3 FATTY-ACID PEROXYGENASE oxygenase#PC00177;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG187164|UniProtKB=T1FP74 T1FP74 20210621 PTHR42881:SF2 PROLYL ENDOPEPTIDASE PROLYL ENDOPEPTIDASE hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 serine protease#PC00203;protease#PC00190 Vasopressin synthesis#P04395>Endo Peptidase#P04596 HELRO|EnsemblGenome=HelroG154853|UniProtKB=T1ELG2 T1ELG2 20197412 PTHR24067:SF154 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 G2 ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Parkinson disease#P00049>Ubc7#P01220;Ubiquitin proteasome pathway#P00060>E2#P01491 HELRO|EnsemblGenome=HelroG159947|UniProtKB=T1EPL2 T1EPL2 20198512 PTHR12232:SF15 SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH PROTEIN HOMOLOG cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG179436|UniProtKB=T1FEP7 T1FEP7 20207296 PTHR11801:SF43 SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION SIGNAL TRANSDUCER AND TRANSCRIPTION ACTIVATOR sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 PDGF signaling pathway#P00047>STAT#P01173;EGF receptor signaling pathway#P00018>STAT#P00561 HELRO|EnsemblGenome=HelroG99418|UniProtKB=T1G9S7 T1G9S7 20217823 PTHR13482:SF3 MICRORNA PROCESSOR COMPLEX SUBUNIT DGCR8 MICROPROCESSOR COMPLEX SUBUNIT DGCR8 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;double-stranded RNA binding#GO:0003725;binding#GO:0005488;organic cyclic compound binding#GO:0097159 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;RNA metabolic process#GO:0016070;regulatory ncRNA processing#GO:0070918;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;miRNA processing#GO:0035196;regulatory ncRNA-mediated gene silencing#GO:0031047;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;negative regulation of metabolic process#GO:0009892;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;primary miRNA processing#GO:0031053;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;endoribonuclease complex#GO:1902555;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;endonuclease complex#GO:1905348;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG165853|UniProtKB=T1EXD1 T1EXD1 20201231 PTHR36168:SF1 CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191881|UniProtKB=T1FTD8 T1FTD8 20212085 PTHR12308:SF74 ANOCTAMIN ANOCTAMIN inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216 localization#GO:0051179;inorganic anion transmembrane transport#GO:0098661;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;transport#GO:0006810;chloride transport#GO:0006821;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG70944|UniProtKB=T1G0E7 T1G0E7 20214545 PTHR11845:SF13 5'-DEOXYNUCLEOTIDASE HDDC2 5'-DEOXYNUCLEOTIDASE HDDC2 HELRO|EnsemblGenome=HelroG77494|UniProtKB=T1G2Y6 T1G2Y6 20215434 PTHR48033:SF10 RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN RNA-BINDING PROTEIN SQUID nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG74874|UniProtKB=T1G1W9 T1G1W9 20215067 PTHR18934:SF99 ATP-DEPENDENT RNA HELICASE ATP-DEPENDENT RNA HELICASE DHX37-RELATED nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG62459|UniProtKB=T1FX10 T1FX10 20213358 PTHR43053:SF4 GLYCOSIDASE FAMILY 31 MYOGENESIS-REGULATING GLYCOSIDASE glucosidase#PC00108 HELRO|EnsemblGenome=HelroG78594|UniProtKB=T1G3D6 T1G3D6 20215584 PTHR12609:SF0 MICROTUBULE ASSOCIATED PROTEIN XMAP215 CYTOSKELETON-ASSOCIATED PROTEIN 5 cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;transferase activity#GO:0016740;binding#GO:0005488;catalytic activity#GO:0003824;protein binding#GO:0005515;microtubule binding#GO:0008017;catalytic activity, acting on a protein#GO:0140096 establishment or maintenance of cell polarity#GO:0007163;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;mitotic spindle organization#GO:0007052;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;centrosome cycle#GO:0007098;protein-containing complex assembly#GO:0065003;centrosome duplication#GO:0051298;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular process#GO:0009987;microtubule polymerization or depolymerization#GO:0031109;microtubule organizing center organization#GO:0031023;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;microtubule polymerization#GO:0046785;microtubule-based process#GO:0007017;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;supramolecular fiber organization#GO:0097435;protein polymerization#GO:0051258;cell cycle#GO:0007049;cytoskeleton organization#GO:0007010;spindle organization#GO:0007051 supramolecular complex#GO:0099080;spindle pole#GO:0000922;microtubule organizing center#GO:0005815;kinetochore#GO:0000776;condensed chromosome, centromeric region#GO:0000779;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;centrosome#GO:0005813;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;chromosome#GO:0005694;microtubule cytoskeleton#GO:0015630;chromosomal region#GO:0098687;cytoskeleton#GO:0005856;microtubule plus-end#GO:0035371;spindle#GO:0005819;microtubule#GO:0005874 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG173137|UniProtKB=T1F6F7 T1F6F7 20204406 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168594|UniProtKB=T1F0R9 T1F0R9 20202419 PTHR23064:SF72 TROPONIN TROPONIN C, SKELETAL MUSCLE cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG183997|UniProtKB=T1FKE4 T1FKE4 20209293 PTHR12755:SF3 CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG194324|UniProtKB=T1FVX7 T1FVX7 20212973 PTHR19316:SF35 PROTEIN FOLDING REGULATOR NUCLEOTIDE EXCHANGE FACTOR SIL1 nucleoside phosphate binding#GO:1901265;nucleotide binding#GO:0000166;heterocyclic compound binding#GO:1901363;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;molecular function regulator activity#GO:0098772 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG105775|UniProtKB=T1EDX5 T1EDX5 20194777 PTHR12286:SF5 SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;glycolipid metabolic process#GO:0006664;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;liposaccharide metabolic process#GO:1903509;membrane lipid biosynthetic process#GO:0046467;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;membrane lipid metabolic process#GO:0006643;glycolipid biosynthetic process#GO:0009247;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG166002|UniProtKB=T1EXK4 T1EXK4 20201304 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG177587|UniProtKB=T1FBW6 T1FBW6 20206315 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG169254|UniProtKB=T1F1N1 T1F1N1 20202731 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188995|UniProtKB=T1FQJ5 T1FQJ5 20211092 PTHR12299:SF17 HYALURONIC ACID-BINDING PROTEIN 4 AT19571P-RELATED nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG177552|UniProtKB=T1FBV4 T1FBV4 20206303 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG66203|UniProtKB=T1FYI5 T1FYI5 20213883 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165857|UniProtKB=T1EXD3 T1EXD3 20201233 PTHR19269:SF45 TROPOMYOSIN TROPOMYOSIN-1, ISOFORMS 33_34 cytoskeletal protein#PC00085;actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG167592|UniProtKB=T1EZJ0 T1EZJ0 20201990 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG176352|UniProtKB=T1FAF3 T1FAF3 20205802 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG76709|UniProtKB=T1G2N0 T1G2N0 20215328 PTHR43173:SF28 ABC1 FAMILY PROTEIN AARF DOMAIN CONTAINING KINASE 5 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG165434|UniProtKB=T1EWS4 T1EWS4 20201024 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157349|UniProtKB=T1EMA0 T1EMA0 20197700 PTHR11827:SF103 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium ion transmembrane transporter activity#GO:0015079;sodium ion transmembrane transporter activity#GO:0015081;symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;chloride transmembrane transporter activity#GO:0015108;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 inorganic ion homeostasis#GO:0098771;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;sodium ion homeostasis#GO:0055078;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;inorganic anion transmembrane transport#GO:0098661;import across plasma membrane#GO:0098739;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;inorganic anion transport#GO:0015698;potassium ion transport#GO:0006813;regulation of anatomical structure size#GO:0090066;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;monoatomic anion transmembrane transport#GO:0098656;chloride transport#GO:0006821;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;cellular component organization#GO:0016043;cellular process#GO:0009987;chemical homeostasis#GO:0048878;regulation of cellular component size#GO:0032535;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;sodium ion transport#GO:0006814;regulation of cell size#GO:0008361;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;sodium ion transmembrane transport#GO:0035725;potassium ion import across plasma membrane#GO:1990573 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG192765|UniProtKB=T1FU98 T1FU98 20212394 PTHR16219:SF1 AUGMIN SUBUNIT 4 FAMILY MEMBER HAUS AUGMIN-LIKE COMPLEX SUBUNIT 4 cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;cellular component organization#GO:0016043;cellular process#GO:0009987;chromosome segregation#GO:0007059;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;spindle assembly#GO:0051225;cytoskeleton organization#GO:0007010;cell cycle#GO:0007049;spindle organization#GO:0007051;non-membrane-bounded organelle assembly#GO:0140694 intracellular non-membrane-bounded organelle#GO:0043232;microtubule associated complex#GO:0005875;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;HAUS complex#GO:0070652;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG67981|UniProtKB=T1FZ89 T1FZ89 20214137 PTHR45701:SF3 SYNAPTOBREVIN FAMILY MEMBER SYNAPTOBREVIN syntaxin binding#GO:0019905;molecular adaptor activity#GO:0060090;protein binding#GO:0005515;SNAP receptor activity#GO:0005484;binding#GO:0005488;SNARE binding#GO:0000149;protein-macromolecule adaptor activity#GO:0030674 localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;vesicle fusion#GO:0006906;membrane fusion#GO:0061025;establishment of localization#GO:0051234;membrane organization#GO:0061024;organelle organization#GO:0006996;organelle membrane fusion#GO:0090174;transport#GO:0006810;vesicle-mediated transport#GO:0016192;vesicle organization#GO:0016050;cellular component organization#GO:0016043;cellular process#GO:0009987;organelle fusion#GO:0048284 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;SNARE complex#GO:0031201;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 Opioid proenkephalin pathway#P05915>SNARE Complex#P05986;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066;Thyrotropin-releasing hormone receptor signaling pathway#P04394>SNARE Complex#P04582;Dopamine receptor mediated signaling pathway#P05912>SNARE Complex#P05956;Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072;Beta3 adrenergic receptor signaling pathway#P04379>SNARE Complex#P04447;5HT4 type receptor mediated signaling pathway#P04376>SNARE Complex#P04428;Opioid prodynorphin pathway#P05916>SNARE Complex#P05996;Alpha adrenergic receptor signaling pathway#P00002>SNARE#P00074;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;5HT3 type receptor mediated signaling pathway#P04375>SNARE Complex#P04423;Ionotropic glutamate receptor pathway#P00037>SNARE Complex#P01013;Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049;Opioid proopiomelanocortin pathway#P05917>SNARE Complex#P06005;Beta1 adrenergic receptor signaling pathway#P04377>SNARE Complex#P04435;Cortocotropin releasing factor receptor signaling pathway#P04380>SNARE Complex#P04457;Metabotropic glutamate receptor group III pathway#P00039>SNARE Complex#P01042;Oxytocin receptor mediated signaling pathway#P04391>SNARE Complex#P04532;5HT2 type receptor mediated signaling pathway#P04374>SNARE Complex#P04415;5HT1 type receptor mediated signaling pathway#P04373>SNARE Complex#P04405;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;Beta2 adrenergic receptor signaling pathway#P04378>SNARE Complex#P04442 HELRO|EnsemblGenome=HelroG76268|UniProtKB=T1G2H5 T1G2H5 20215273 PTHR13321:SF2 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 18 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 18 molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;RNA metabolic process#GO:0016070;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;gene expression#GO:0010467;regulation of RNA biosynthetic process#GO:2001141;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;cellular nitrogen compound biosynthetic process#GO:0044271;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;regulation of DNA-templated transcription#GO:0006355;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;regulation of primary metabolic process#GO:0080090;nucleic acid metabolic process#GO:0090304;regulation of cellular biosynthetic process#GO:0031326;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;regulation of metabolic process#GO:0019222;transcription by RNA polymerase II#GO:0006366;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;core mediator complex#GO:0070847;RNA polymerase II transcription regulator complex#GO:0090575;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG81610|UniProtKB=T1G4G3 T1G4G3 20215961 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG79049|UniProtKB=T1G3J3 T1G3J3 20215641 PTHR11909:SF428 CASEIN KINASE-RELATED CASEIN KINASE I ISOFORM EPSILON transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of protein metabolic process#GO:0051246;regulation of catabolic process#GO:0009894;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of signal transduction#GO:0009967;regulation of proteolysis involved in protein catabolic process#GO:1903050;positive regulation of proteolysis#GO:0045862;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;regulation of signal transduction#GO:0009966;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;positive regulation of proteolysis involved in protein catabolic process#GO:1903052;macromolecule metabolic process#GO:0043170;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cellular metabolic process#GO:0044237;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;cell communication#GO:0007154;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;positive regulation of canonical Wnt signaling pathway#GO:0090263;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of catabolic process#GO:0009896;positive regulation of protein catabolic process#GO:0045732;import into cell#GO:0098657;regulation of metabolic process#GO:0019222;positive regulation of nitrogen compound metabolic process#GO:0051173;signal transduction#GO:0007165;macromolecule modification#GO:0043412;regulation of signaling#GO:0023051;transport#GO:0006810;positive regulation of proteasomal protein catabolic process#GO:1901800;protein modification process#GO:0036211;regulation of protein catabolic process#GO:0042176;peptidyl-amino acid modification#GO:0018193;positive regulation of Wnt signaling pathway#GO:0030177;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;positive regulation of response to stimulus#GO:0048584;positive regulation of metabolic process#GO:0009893;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;signaling#GO:0023052;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;metabolic process#GO:0008152;regulation of cell communication#GO:0010646;regulation of proteolysis#GO:0030162;cellular response to stimulus#GO:0051716;organonitrogen compound metabolic process#GO:1901564;protein phosphorylation#GO:0006468;cellular process#GO:0009987;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of proteasomal protein catabolic process#GO:0061136;regulation of primary metabolic process#GO:0080090;localization#GO:0051179;response to stimulus#GO:0050896;positive regulation of protein metabolic process#GO:0051247;regulation of macromolecule metabolic process#GO:0060255;regulation of Wnt signaling pathway#GO:0030111;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;CCKR signaling map#P06959>CK1delta/epsilon#P07089;Hedgehog signaling pathway#P00025>Casein kinase I#P00681;Circadian clock system#P00015>Casein kinase I#P00502;Parkinson disease#P00049>Casein kinase I#P01242 HELRO|EnsemblGenome=HelroG165732|UniProtKB=T1EX80 T1EX80 20201180 PTHR46459:SF1 E1A-BINDING PROTEIN P400-RELATED E1A-BINDING PROTEIN P400 protein-containing complex binding#GO:0044877;binding#GO:0005488;chromatin binding#GO:0003682 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;NuA4 histone acetyltransferase complex#GO:0035267;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;chromosome#GO:0005694 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG190766|UniProtKB=T1FSA0 T1FSA0 20211697 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG73211|UniProtKB=T1G1B8 T1G1B8 20214866 PTHR12760:SF0 TETRATRICOPEPTIDE REPEAT PROTEIN ER MEMBRANE PROTEIN COMPLEX SUBUNIT 2 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein folding#GO:0006457;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane protein complex#GO:0098796;endoplasmic reticulum protein-containing complex#GO:0140534;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;EMC complex#GO:0072546;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 chaperone#PC00072 HELRO|EnsemblGenome=HelroG114688|UniProtKB=T1EG40 T1EG40 20195542 PTHR13195:SF0 PSEUDOURIDINE SYNTHASE-RELATED PSEUDOURIDYLATE SYNTHASE TRUB2, MITOCHONDRIAL lyase#PC00144 HELRO|EnsemblGenome=HelroG113916|UniProtKB=T1EFX4 T1EFX4 20195476 PTHR11785:SF516 AMINO ACID TRANSPORTER AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN L-amino acid transmembrane transporter activity#GO:0015179;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;amino acid transport#GO:0006865;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;nitrogen compound transport#GO:0071705;organic acid transmembrane transport#GO:1903825;carboxylic acid transport#GO:0046942;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039 transporter#PC00227 HELRO|EnsemblGenome=HelroG102089|UniProtKB=T1ED79 T1ED79 20194531 PTHR45697:SF3 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED DEAD END carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168 organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG191784|UniProtKB=T1FTB5 T1FTB5 20212062 PTHR11412:SF136 MACROGLOBULIN / COMPLEMENT CD109 ANTIGEN protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG106545|UniProtKB=T1EE33 T1EE33 20194835 PTHR11599:SF11 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT ALPHA TYPE-6 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;proteasome complex#GO:0000502;membrane-bounded organelle#GO:0043227;endopeptidase complex#GO:1905369;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protease#PC00190;protein modifying enzyme#PC00260 Parkinson disease#P00049>20S proteasome#P01227 HELRO|EnsemblGenome=HelroG179216|UniProtKB=T1FED3 T1FED3 20207182 PTHR13284:SF4 GH01354P C2H2-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159;ribonucleoprotein complex binding#GO:0043021;mRNA binding#GO:0003729;protein-containing complex binding#GO:0044877;mRNA 3'-UTR binding#GO:0003730 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG173235|UniProtKB=T1F6L3 T1F6L3 20204462 PTHR15405:SF0 PROLINE-RICH NUCLEAR RECEPTOR COACTIVATOR AAQUETZALLI, ISOFORM A membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG159690|UniProtKB=T1EPB2 T1EPB2 20198412 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG75625|UniProtKB=T1G277 T1G277 20215175 PTHR22891:SF111 EUKARYOTIC TRANSLATION INITIATION FACTOR 2C PROTEIN ARGONAUTE-3 catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;nuclease activity#GO:0004518;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521 negative regulation of gene expression#GO:0010629;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;P granule#GO:0043186;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG91150|UniProtKB=T1G803 T1G803 20217200 PTHR23064:SF72 TROPONIN TROPONIN C, SKELETAL MUSCLE cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG90797|UniProtKB=T1G7W5 T1G7W5 20217162 PTHR24070:SF416 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY RAS-LIKE PROTEIN 1 GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 small GTPase#PC00208;G-protein#PC00020 TGF-beta signaling pathway#P00052>Ras-GDP#P01291;FGF signaling pathway#P00021>Ras#P00633;TGF-beta signaling pathway#P00052>Ras-GTP#P01280;PDGF signaling pathway#P00047>Ras#P01154;EGF receptor signaling pathway#P00018>Ras#P00552;Angiogenesis#P00005>Ras#P00238;Ras Pathway#P04393>Ras#P04547;PI3 kinase pathway#P00048>Ras#P01182;p53 pathway feedback loops 2#P04398>Ras#P04651;Integrin signalling pathway#P00034>Ras#P00916;VEGF signaling pathway#P00056>Ras#P01411 HELRO|EnsemblGenome=HelroG164568|UniProtKB=T1EVK7 T1EVK7 20200607 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG86699|UniProtKB=T1G6F5 T1G6F5 20216652 PTHR11267:SF196 T-BOX PROTEIN-RELATED T-BOX PROTEIN 30_42-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cell fate commitment#GO:0045165;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;cell fate specification#GO:0001708;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HELRO|EnsemblGenome=HelroG175856|UniProtKB=T1F9S5 T1F9S5 20205574 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161542|UniProtKB=T1ERL7 T1ERL7 20199217 PTHR42790:SF19 AMINOTRANSFERASE KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL transaminase activity#GO:0008483;transferase activity#GO:0016740;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;nitrogen compound metabolic process#GO:0006807;alpha-amino acid metabolic process#GO:1901605;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 transaminase#PC00216 HELRO|EnsemblGenome=HelroG171198|UniProtKB=T1F3X5 T1F3X5 20203524 PTHR47055:SF3 DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 HELRO|EnsemblGenome=HelroG161480|UniProtKB=T1ERI8 T1ERI8 20199188 PTHR24173:SF40 ANKYRIN REPEAT CONTAINING AGAP006757-PA scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG83409|UniProtKB=T1G552 T1G552 20216200 PTHR24346:SF82 MAP/MICROTUBULE AFFINITY-REGULATING KINASE KP78A-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG194025|UniProtKB=T1FVL0 T1FVL0 20212856 PTHR12461:SF104 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 5 tRNA binding#GO:0000049;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;carbohydrate derivative metabolic process#GO:1901135;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;cellular metabolic process#GO:0044237;organonitrogen compound metabolic process#GO:1901564;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nucleic acid metabolic process#GO:0090304;glycosyl compound metabolic process#GO:1901657 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG194553|UniProtKB=T1FW69 T1FW69 20213065 PTHR10625:SF10 HISTONE DEACETYLASE HDAC1-RELATED HISTONE DEACETYLASE HDAC1 histone modifying activity#GO:0140993;histone deacetylase activity#GO:0004407;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;deacetylase activity#GO:0019213;catalytic activity, acting on a protein#GO:0140096 protein-DNA complex organization#GO:0071824;cellular component organization#GO:0016043;cellular process#GO:0009987;epigenetic regulation of gene expression#GO:0040029;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;protein-containing complex organization#GO:0043933;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 Wnt signaling pathway#P00057>Histone deacetylase#P01472;p53 pathway#P00059>HDAC1#P04612 HELRO|EnsemblGenome=HelroG81861|UniProtKB=T1G4J6 T1G4J6 20215994 PTHR23101:SF122 RAB GDP/GTP EXCHANGE FACTOR RABAPTIN-5-ASSOCIATED EXCHANGE FACTOR FOR RAB5 nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;binding#GO:0005488;molecular function regulator activity#GO:0098772;enzyme binding#GO:0019899;protein binding#GO:0005515;small GTPase binding#GO:0031267;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;endocytic vesicle#GO:0030139;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG108727|UniProtKB=T1EEL9 T1EEL9 20195021 PTHR22901:SF0 SIALATE O-ACETYLESTERASE SIALATE O-ACETYLESTERASE hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 carbohydrate metabolic process#GO:0005975;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238;metabolic process#GO:0008152 esterase#PC00097 HELRO|EnsemblGenome=HelroG164483|UniProtKB=T1EVH5 T1EVH5 20200575 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159872|UniProtKB=T1EPH3 T1EPH3 20198473 PTHR12542:SF41 EXOCYST COMPLEX PROTEIN EXO70 EXOCYST COMPLEX COMPONENT 7 localization#GO:0051179;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;export from cell#GO:0140352;secretion by cell#GO:0032940 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;vesicle tethering complex#GO:0099023;exocyst#GO:0000145;cell cortex#GO:0005938;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG109284|UniProtKB=T1EES1 T1EES1 20195073 PTHR13465:SF2 UPF0183 PROTEIN PHAGOSOME ASSEMBLY FACTOR 1 HELRO|EnsemblGenome=HelroG71529|UniProtKB=T1G0M8 T1G0M8 20214626 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG161364|UniProtKB=T1ERE4 T1ERE4 20199144 PTHR19303:SF71 TRANSPOSON ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG167091|UniProtKB=T1EZ05 T1EZ05 20201805 PTHR13454:SF11 PROTEIN MCM10 HOMOLOG PROTEIN MCM10 HOMOLOG sequence-specific double-stranded DNA binding#GO:1990837;DNA replication origin binding#GO:0003688;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;single-stranded DNA binding#GO:0003697;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;DNA-templated DNA replication#GO:0006261;DNA replication#GO:0006260;DNA replication initiation#GO:0006270;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;chromosome#GO:0005694;nuclear replication fork#GO:0043596;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;replication fork#GO:0005657 HELRO|EnsemblGenome=HelroG193557|UniProtKB=T1FV47 T1FV47 20212693 PTHR11134:SF3 ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER AP COMPLEX SUBUNIT BETA localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;cellular process#GO:0009987;transport#GO:0006810 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG165500|UniProtKB=T1EWX2 T1EWX2 20201072 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG90028|UniProtKB=T1G7K0 T1G7K0 20217047 PTHR10024:SF344 SYNAPTOTAGMIN SYNAPTOTAGMIN-7 cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;phosphatidylserine binding#GO:0001786;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;protein binding#GO:0005515;clathrin binding#GO:0030276;lipid binding#GO:0008289;ion binding#GO:0043167;phospholipid binding#GO:0005543;SNARE binding#GO:0000149 vesicle fusion#GO:0006906;cellular localization#GO:0051641;synaptic vesicle cycle#GO:0099504;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;regulated exocytosis#GO:0045055;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;secretion#GO:0046903;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;signal release#GO:0023061;vesicle organization#GO:0016050;calcium-ion regulated exocytosis#GO:0017156;signaling#GO:0023052;cell-cell signaling#GO:0007267;synaptic vesicle exocytosis#GO:0016079;organelle fusion#GO:0048284;secretion by cell#GO:0032940;neurotransmitter secretion#GO:0007269;trans-synaptic signaling#GO:0099537;vesicle-mediated transport#GO:0016192;cell communication#GO:0007154;cellular component organization#GO:0016043;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;membrane fusion#GO:0061025;signal release from synapse#GO:0099643;exocytosis#GO:0006887;organelle organization#GO:0006996;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;export from cell#GO:0140352;vesicle-mediated transport in synapse#GO:0099003 synapse#GO:0045202;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;axon#GO:0030424;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;neuron projection#GO:0043005;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;transport vesicle#GO:0030133;cell projection#GO:0042995;secretory vesicle#GO:0099503;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG194726|UniProtKB=T1FWC6 T1FWC6 20213121 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG70524|UniProtKB=T1G076 T1G076 20214474 PTHR24208:SF105 LIM/HOMEOBOX PROTEIN LHX DLIM1 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;neurogenesis#GO:0022008;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;system development#GO:0048731;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;regulation of macromolecule biosynthetic process#GO:0010556;generation of neurons#GO:0048699;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG172570|UniProtKB=T1F5J3 T1F5J3 20204092 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177298|UniProtKB=T1FBH0 T1FBH0 20206169 PTHR13720:SF14 WD-40 REPEAT PROTEIN CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 52 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG189111|UniProtKB=T1FQN9 T1FQN9 20211136 PTHR24034:SF89 EGF-LIKE DOMAIN-CONTAINING PROTEIN COMPLEMENT COMPONENT C1Q RECEPTOR extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG172281|UniProtKB=T1F564 T1F564 20203963 PTHR28457:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 189 SIMILAR TO 4930578I06RIK PROTEIN HELRO|EnsemblGenome=HelroG190339|UniProtKB=T1FRX1 T1FRX1 20211568 PTHR13322:SF2 C1ORF73 PROTEIN INTEGRATOR COMPLEX SUBUNIT 7 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;snRNA metabolic process#GO:0016073;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;snRNA 3'-end processing#GO:0034472;snRNA processing#GO:0016180;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;integrator complex#GO:0032039 HELRO|EnsemblGenome=HelroG69344|UniProtKB=T1FZT6 T1FZT6 20214334 PTHR24012:SF491 RNA BINDING PROTEIN LD36772P-RELATED nucleic acid binding#GO:0003676;single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159;mRNA binding#GO:0003729;poly(A) binding#GO:0008143;mRNA 3'-UTR binding#GO:0003730 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG71969|UniProtKB=T1G0T7 T1G0T7 20214685 PTHR20971:SF0 U6 SNRNA-ASSOCIATED PROTEIN U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 U6 snRNP#GO:0005688;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;U4/U6 x U5 tri-snRNP complex#GO:0046540;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;protein-containing complex#GO:0032991;small nuclear ribonucleoprotein complex#GO:0030532;spliceosomal tri-snRNP complex#GO:0097526;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG194936|UniProtKB=T1FWL2 T1FWL2 20213207 PTHR21538:SF23 ANILLIN/RHOTEKIN RTKN ANILLIN cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cell division#GO:0051301;actomyosin contractile ring assembly#GO:0000915;cell cycle process#GO:0022402;actomyosin structure organization#GO:0031032;cellular component organization#GO:0016043;cellular process#GO:0009987;cytokinetic process#GO:0032506;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;mitotic cytokinesis#GO:0000281;mitotic cell cycle#GO:0000278;actin filament-based process#GO:0030029;organelle organization#GO:0006996;cortical cytoskeleton organization#GO:0030865;cytoskeleton-dependent cytokinesis#GO:0061640;cell cycle#GO:0007049;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cytokinesis#GO:0000910;cortical actin cytoskeleton organization#GO:0030866;septin cytoskeleton organization#GO:0032185 actomyosin contractile ring#GO:0005826;cortical cytoskeleton#GO:0030863;cell cortex#GO:0005938;cell periphery#GO:0071944;cortical actin cytoskeleton#GO:0030864;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cell division site#GO:0032153;contractile ring#GO:0070938;cytoskeleton#GO:0005856 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG62989|UniProtKB=T1FX90 T1FX90 20213438 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG143881|UniProtKB=T1EJC8 T1EJC8 20196678 PTHR22811:SF184 TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 10 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG170146|UniProtKB=T1F2Q0 T1F2Q0 20203099 PTHR43827:SF13 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE ALDO_KETO REDUCTASE FAMILY PROTEIN oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG179985|UniProtKB=T1FFB1 T1FFB1 20207510 PTHR31144:SF1 UPF0602 PROTEIN C4ORF47 UPF0602 PROTEIN C4ORF47 supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cytoplasmic microtubule#GO:0005881;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG184006|UniProtKB=T1FKE7 T1FKE7 20209296 PTHR31761:SF1 GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEINS-INTERACTING PROTEIN 1 GADD45GIP1 LARGE RIBOSOMAL SUBUNIT PROTEIN ML64 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG168752|UniProtKB=T1F0X5 T1F0X5 20202475 PTHR23024:SF24 ARYLACETAMIDE DEACETYLASE ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN deacetylase#PC00087;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG161712|UniProtKB=T1ERT7 T1ERT7 20199287 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG167215|UniProtKB=T1EZ55 T1EZ55 20201855 PTHR13906:SF14 PORCUPINE LYSOPHOSPHOLIPID ACYLTRANSFERASE 5 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;O-acyltransferase activity#GO:0008374 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;glycerolipid biosynthetic process#GO:0045017;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;glycerophospholipid metabolic process#GO:0006650;organic substance biosynthetic process#GO:1901576;lipid modification#GO:0030258;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;phosphatidylcholine biosynthetic process#GO:0006656;glycerolipid metabolic process#GO:0046486;nitrogen compound metabolic process#GO:0006807;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;phosphatidylcholine metabolic process#GO:0046470;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transferase#PC00220;acetyltransferase#PC00038;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG73817|UniProtKB=T1G1I6 T1G1I6 20214934 PTHR46194:SF1 PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED HELRO|EnsemblGenome=HelroG191890|UniProtKB=T1FTE2 T1FTE2 20212089 PTHR11586:SF33 TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1 translational protein#PC00263 HELRO|EnsemblGenome=HelroG163461|UniProtKB=T1EU29 T1EU29 20200079 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG87798|UniProtKB=T1G6V4 T1G6V4 20216801 PTHR47202:SF2 HISTIDINE-RICH GLYCOPROTEIN G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG64632|UniProtKB=T1G185 T1G185 20214833 PTHR19303:SF71 TRANSPOSON ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG98836|UniProtKB=T1G9Q1 T1G9Q1 20217797 PTHR12126:SF11 NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL protein-containing complex binding#GO:0044877;binding#GO:0005488 cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;ubiquinone biosynthetic process#GO:0006744;small molecule biosynthetic process#GO:0044283;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG185875|UniProtKB=T1FND8 T1FND8 20210335 PTHR43561:SF3 FAMILY NOT NAMED HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 lipid metabolic process#GO:0006629;oxoacid metabolic process#GO:0043436;cellular metabolic process#GO:0044237;lipid oxidation#GO:0034440;lipid modification#GO:0030258;lipid catabolic process#GO:0016042;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;fatty acid catabolic process#GO:0009062;primary metabolic process#GO:0044238;fatty acid metabolic process#GO:0006631;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;fatty acid beta-oxidation#GO:0006635;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;cellular lipid metabolic process#GO:0044255;carboxylic acid catabolic process#GO:0046395;cellular lipid catabolic process#GO:0044242;carboxylic acid metabolic process#GO:0019752;cellular catabolic process#GO:0044248;monocarboxylic acid catabolic process#GO:0072329;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG177365|UniProtKB=T1FBK4 T1FBK4 20206203 PTHR23507:SF1 ZGC:174356 FI18259P1-RELATED Endothelin signaling pathway#P00019>Adenylate cyclase#P00569 HELRO|EnsemblGenome=HelroG171050|UniProtKB=T1F3R2 T1F3R2 20203461 PTHR47086:SF4 BTB DOMAIN-CONTAINING PROTEIN BTB DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179526|UniProtKB=T1FEU5 T1FEU5 20207344 PTHR23301:SF0 CHITIN BINDING PERITROPHIN-A CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG184995|UniProtKB=T1FM89 T1FM89 20209938 PTHR45615:SF40 MYOSIN HEAVY CHAIN, NON-MUSCLE MYOSIN HEAVY CHAIN, NON-MUSCLE microfilament motor activity#GO:0000146;cytoskeletal protein binding#GO:0008092;ATP-dependent activity#GO:0140657;binding#GO:0005488;actin filament binding#GO:0051015;cytoskeletal motor activity#GO:0003774;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779 supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;supramolecular fiber#GO:0099512;supramolecular polymer#GO:0099081;myosin complex#GO:0016459;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Myosin#P00867;Cytoskeletal regulation by Rho GTPase#P00016>Myosin#P00522;Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG156770|UniProtKB=T1EM07 T1EM07 20197607 PTHR11834:SF0 TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED PROTEIN SCALLOPED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG185689|UniProtKB=T1FN55 T1FN55 20210253 PTHR21824:SF4 TRANSMEMBRANE PROTEIN 177 TRANSMEMBRANE PROTEIN 177 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG168029|UniProtKB=T1F028 T1F028 20202178 PTHR24023:SF1115 COLLAGEN ALPHA FIBRILLAR COLLAGEN NC1 DOMAIN-CONTAINING PROTEIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG158447|UniProtKB=T1EMT0 T1EMT0 20197880 PTHR46511:SF1 MORN REPEAT-CONTAINING PROTEIN 3 MORN REPEAT-CONTAINING PROTEIN 3 HELRO|EnsemblGenome=HelroG189769|UniProtKB=T1FRC9 T1FRC9 20211376 PTHR13315:SF0 METALLO PHOSPHOESTERASE RELATED METALLOPHOSPHOESTERASE 1 esterase#PC00097 HELRO|EnsemblGenome=HelroG189399|UniProtKB=T1FR09 T1FR09 20211256 PTHR47705:SF1 AGAP000321-PA PNP_UDP_1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162308|UniProtKB=T1ESH7 T1ESH7 20199527 PTHR33332:SF48 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG79315|UniProtKB=T1G3M6 T1G3M6 20215674 PTHR10223:SF0 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4 protein binding#GO:0005515;binding#GO:0005488;polyubiquitin modification-dependent protein binding#GO:0031593;modification-dependent protein binding#GO:0140030 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 peptidase complex#GO:1905368;proteasome accessory complex#GO:0022624;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;proteasome regulatory particle#GO:0005838;catalytic complex#GO:1902494;proteasome complex#GO:0000502;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endopeptidase complex#GO:1905369;membrane-bounded organelle#GO:0043227 protease#PC00190;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489;Cell cycle#P00013>Proteasome#P00480 HELRO|EnsemblGenome=HelroG183511|UniProtKB=T1FJR8 T1FJR8 20209067 PTHR22802:SF463 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG178835|UniProtKB=T1FDT3 T1FDT3 20206982 PTHR10590:SF4 SODIUM/NUCLEOSIDE COTRANSPORTER SOLUTE CARRIER FAMILY 28 MEMBER 3 carbohydrate derivative transmembrane transporter activity#GO:1901505;secondary active transmembrane transporter activity#GO:0015291;nucleoside transmembrane transporter activity#GO:0005337;transmembrane transporter activity#GO:0022857;symporter activity#GO:0015293;nucleobase-containing compound transmembrane transporter activity#GO:0015932;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215 localization#GO:0051179;organic substance transport#GO:0071702;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;nucleobase-containing compound transport#GO:0015931;transport#GO:0006810;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG176707|UniProtKB=T1FAT1 T1FAT1 20205930 PTHR12622:SF4 DELTEX-RELATED PROTEIN DELTEX transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cell communication#GO:0007154;cellular process#GO:0009987;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;Notch signaling pathway#GO:0007219 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG162689|UniProtKB=T1ET06 T1ET06 20199706 PTHR12449:SF18 DEATH DOMAIN-CONTAINING PROTEIN DEATH DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170216|UniProtKB=T1F2S8 T1F2S8 20203127 PTHR10156:SF0 2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE 2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric diester hydrolase activity#GO:0008081;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 phosphodiesterase#PC00185;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG86099|UniProtKB=T1G672 T1G672 20216569 PTHR45969:SF69 RING ZINC FINGER PROTEIN-RELATED FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG82648|UniProtKB=T1G4U7 T1G4U7 20216095 PTHR24351:SF202 RIBOSOMAL PROTEIN S6 KINASE CHROMOSOMAL SERINE_THREONINE-PROTEIN KINASE JIL-1 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>P90 RSK#P00888;PDGF signaling pathway#P00047>p90RSK#P01142 HELRO|EnsemblGenome=HelroG106711|UniProtKB=T1EE40 T1EE40 20194842 PTHR12358:SF112 SPHINGOSINE KINASE LD11247P-RELATED transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301;lipid kinase activity#GO:0001727 organic hydroxy compound metabolic process#GO:1901615;lipid metabolic process#GO:0006629;alcohol biosynthetic process#GO:0046165;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic hydroxy compound biosynthetic process#GO:1901617;alcohol metabolic process#GO:0006066;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;membrane lipid biosynthetic process#GO:0046467;sphingolipid metabolic process#GO:0006665;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;membrane lipid metabolic process#GO:0006643;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;phosphorylation#GO:0016310;small molecule biosynthetic process#GO:0044283;cellular lipid metabolic process#GO:0044255;sphingolipid biosynthetic process#GO:0030148;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 kinase#PC00137 HELRO|EnsemblGenome=HelroG88112|UniProtKB=T1G6Y6 T1G6Y6 20216833 PTHR10336:SF159 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phospholipase C activity#GO:0004629;phosphoric diester hydrolase activity#GO:0008081;phospholipase activity#GO:0004620;phosphoric ester hydrolase activity#GO:0042578 lipid metabolic process#GO:0006629;negative regulation of biological process#GO:0048519;signal transduction#GO:0007165;regulation of sequestering of calcium ion#GO:0051282;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of localization#GO:0032879;inorganic ion transmembrane transport#GO:0098660;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;calcium ion transport#GO:0006816;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;glycerolipid metabolic process#GO:0046486;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;intracellular signal transduction#GO:0035556;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular response to stimulus#GO:0051716;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;cellular metabolic process#GO:0044237;release of sequestered calcium ion into cytosol#GO:0051209;cell communication#GO:0007154;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;cellular process#GO:0009987;primary metabolic process#GO:0044238;localization#GO:0051179;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;calcium ion transmembrane import into cytosol#GO:0097553;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;monoatomic ion transport#GO:0006811;cellular lipid metabolic process#GO:0044255;negative regulation of sequestering of calcium ion#GO:0051283;monoatomic cation transmembrane transport#GO:0098655 cell leading edge#GO:0031252;ruffle membrane#GO:0032587;ruffle#GO:0001726;leading edge membrane#GO:0031256;plasma membrane region#GO:0098590;cell projection membrane#GO:0031253;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;plasma membrane#GO:0005886 phospholipase#PC00186 VEGF signaling pathway#P00056>PLC-gamma#P01414;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PLCbetagamma#P00874;FGF signaling pathway#P00021>PLCgamma#P00638;Axon guidance mediated by netrin#P00009>Phospholipase C#P00362;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PLC#P04581;Angiogenesis#P00005>PLC-gamma#P00256;EGF receptor signaling pathway#P00018>PLCgamma#P00556;PDGF signaling pathway#P00047>PLCgamma#P01171;Oxytocin receptor mediated signaling pathway#P04391>PLC beta#P04530;5HT2 type receptor mediated signaling pathway#P04374>PLC#P04412;Histamine H1 receptor mediated signaling pathway#P04385>PLC#P04484 HELRO|EnsemblGenome=HelroG82370|UniProtKB=T1G4R4 T1G4R4 20216062 PTHR11409:SF39 ADENOSINE DEAMINASE ADENOSINE DEAMINASE 2 hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;adenosine deaminase activity#GO:0004000;deaminase activity#GO:0019239;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;nucleoside metabolic process#GO:0009116;glycosyl compound catabolic process#GO:1901658;carbohydrate derivative metabolic process#GO:1901135;heterocycle catabolic process#GO:0046700;organonitrogen compound catabolic process#GO:1901565;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase metabolic process#GO:0009112;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;purine-containing compound catabolic process#GO:0072523;organic cyclic compound metabolic process#GO:1901360;purine nucleoside metabolic process#GO:0042278;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;purine-containing compound metabolic process#GO:0072521;catabolic process#GO:0009056;nucleoside catabolic process#GO:0009164;organic substance catabolic process#GO:1901575;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;carbohydrate derivative catabolic process#GO:1901136;purine nucleobase metabolic process#GO:0006144;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;purine nucleoside catabolic process#GO:0006152;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;aromatic compound catabolic process#GO:0019439;nucleobase-containing compound biosynthetic process#GO:0034654;small molecule catabolic process#GO:0044282;nucleobase-containing small molecule catabolic process#GO:0034656;adenosine metabolic process#GO:0046085;organic cyclic compound catabolic process#GO:1901361;aromatic compound biosynthetic process#GO:0019438;small molecule biosynthetic process#GO:0044283;nucleobase-containing compound catabolic process#GO:0034655;glycosyl compound metabolic process#GO:1901657;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 deaminase#PC00088;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG168132|UniProtKB=T1F073 T1F073 20202223 PTHR24118:SF99 POTE ANKYRIN DOMAIN POTE ANKYRIN DOMAIN FAMILY MEMBER 3C-RELATED membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG101631|UniProtKB=T1ED61 T1ED61 20194513 PTHR23115:SF188 TRANSLATION FACTOR HBS1-LIKE PROTEIN GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;translation#GO:0006412;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG138063|UniProtKB=T1EIR1 T1EIR1 20196461 PTHR11849:SF133 ETS ETS DOMAIN-CONTAINING PROTEIN transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>ELK#P00890;Parkinson disease#P00049>Elk-1#P01233 HELRO|EnsemblGenome=HelroG63599|UniProtKB=T1FXI0 T1FXI0 20213528 PTHR11003:SF334 POTASSIUM CHANNEL, SUBFAMILY K FI03418P monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG183297|UniProtKB=T1FJF5 T1FJF5 20208954 PTHR10697:SF13 MAMMALIAN EPENDYMIN-RELATED PROTEIN 1 RICIN B LECTIN DOMAIN-CONTAINING PROTEIN cytoplasm#GO:0005737;lysosome#GO:0005764;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;vacuole#GO:0005773;cellular anatomical entity#GO:0110165;lytic vacuole#GO:0000323;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG82345|UniProtKB=T1G4Q9 T1G4Q9 20216057 PTHR14336:SF15 TANDEM PH DOMAIN CONTAINING PROTEIN DUAL ADAPTER FOR PHOSPHOTYROSINE AND 3-PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDE HELRO|EnsemblGenome=HelroG70006|UniProtKB=T1G014 T1G014 20214412 PTHR47977:SF18 RAS-RELATED PROTEIN RAB RABX5 GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;transport#GO:0006810 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG74189|UniProtKB=T1G1N4 T1G1N4 20214982 PTHR18966:SF422 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED signaling receptor activity#GO:0038023;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;ligand-gated channel activity#GO:0022834 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019 HELRO|EnsemblGenome=HelroG116471|UniProtKB=T1EGF2 T1EGF2 20195654 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED FMRFAMIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG190385|UniProtKB=T1FRY3 T1FRY3 20211580 PTHR32026:SF10 METHYLTRANSFERASE-LIKE PROTEIN 24 METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG80278|UniProtKB=T1G3Z4 T1G3Z4 20215792 PTHR12448:SF0 ATP SYNTHASE EPSILON CHAIN, MITOCHONDRIAL ATP SYNTHASE SUBUNIT EPSILON, MITOCHONDRIAL monoatomic cation channel activity#GO:0005261;ligase activity#GO:0016874;inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;catalytic activity#GO:0003824;proton transmembrane transporter activity#GO:0015078;proton channel activity#GO:0015252;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;inorganic cation transmembrane transporter activity#GO:0022890;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 cellular aromatic compound metabolic process#GO:0006725;ribonucleoside triphosphate metabolic process#GO:0009199;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative metabolic process#GO:1901135;ATP biosynthetic process#GO:0006754;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;energy derivation by oxidation of organic compounds#GO:0015980;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;purine nucleoside triphosphate biosynthetic process#GO:0009145;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;heterocycle metabolic process#GO:0046483;purine ribonucleoside triphosphate metabolic process#GO:0009205;generation of precursor metabolites and energy#GO:0006091;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;ribonucleoside triphosphate biosynthetic process#GO:0009201;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;proton motive force-driven ATP synthesis#GO:0015986;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;oxidative phosphorylation#GO:0006119;aromatic compound biosynthetic process#GO:0019438;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;purine nucleoside triphosphate metabolic process#GO:0009144;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG125154|UniProtKB=T1EH46 T1EH46 20195896 PTHR45787:SF1 LD11652P LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;protein binding#GO:0005515;transcription factor binding#GO:0008134;DNA-binding transcription factor binding#GO:0140297 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG188417|UniProtKB=T1FPZ0 T1FPZ0 20210887 PTHR13318:SF193 PARTNER OF PAIRED, ISOFORM B-RELATED F-BOX_LRR-REPEAT PROTEIN 16 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234 HELRO|EnsemblGenome=HelroG84081|UniProtKB=T1G5E4 T1G5E4 20216291 PTHR11803:SF39 2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA 2-IMINOBUTANOATE_2-IMINOPROPANOATE DEAMINASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;deaminase activity#GO:0019239;catalytic activity#GO:0003824 organonitrogen compound metabolic process#GO:1901564;catabolic process#GO:0009056;organonitrogen compound catabolic process#GO:1901565;organic substance catabolic process#GO:1901575;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 deaminase#PC00088;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG69263|UniProtKB=T1FZS1 T1FZS1 20214319 PTHR24418:SF373 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE SRC42A protein tyrosine kinase activity#GO:0004713;non-membrane spanning protein tyrosine kinase activity#GO:0004715;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein binding#GO:0005515;catalytic activity, acting on a protein#GO:0140096;signaling receptor binding#GO:0005102;kinase activity#GO:0016301;protein kinase activity#GO:0004672 response to external biotic stimulus#GO:0043207;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;immune response#GO:0006955;developmental process#GO:0032502;cell communication#GO:0007154;cellular process#GO:0009987;defense response to symbiont#GO:0140546;regulation of biological process#GO:0050789;immune system process#GO:0002376;response to stimulus#GO:0050896;response to external stimulus#GO:0009605;cell differentiation#GO:0030154;enzyme-linked receptor protein signaling pathway#GO:0007167;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to other organism#GO:0098542;regulation of cellular process#GO:0050794;response to other organism#GO:0051707;cell surface receptor signaling pathway#GO:0007166;biological process involved in interspecies interaction between organisms#GO:0044419;biological regulation#GO:0065007;innate immune response#GO:0045087;defense response#GO:0006952;signaling#GO:0023052;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169 non-receptor tyrosine protein kinase#PC00168 Parkinson disease#P00049>Src kinase#P01230;Integrin signalling pathway#P00034>Src#P00940 HELRO|EnsemblGenome=HelroG73194|UniProtKB=T1G1B6 T1G1B6 20214864 PTHR12964:SF0 NADH-UBIQUINONE OXIDOREDUCTASE B14 SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6 response to stimulus#GO:0050896;response to stress#GO:0006950;response to oxidative stress#GO:0006979 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transporter complex#GO:1990351;oxidoreductase complex#GO:1990204;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;respirasome#GO:0070469;mitochondrial respiratory chain complex I#GO:0005747;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;mitochondrial respirasome#GO:0005746;transmembrane transporter complex#GO:1902495;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;respiratory chain complex I#GO:0045271;NADH dehydrogenase complex#GO:0030964;mitochondrial protein-containing complex#GO:0098798 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG64185|UniProtKB=T1FXR0 T1FXR0 20213608 PTHR10794:SF45 ABHYDROLASE DOMAIN-CONTAINING PROTEIN MONOACYLGLYCEROL LIPASE ABHD2 hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824 male gamete generation#GO:0048232;neutral lipid catabolic process#GO:0046461;lipid catabolic process#GO:0016042;acylglycerol metabolic process#GO:0006639;lipid biosynthetic process#GO:0008610;hormone-mediated signaling pathway#GO:0009755;carboxylic acid biosynthetic process#GO:0046394;neutral lipid metabolic process#GO:0006638;regulation of biological process#GO:0050789;cellular response to hormone stimulus#GO:0032870;spermatogenesis#GO:0007283;reproductive process#GO:0022414;carboxylic acid catabolic process#GO:0046395;cellular lipid catabolic process#GO:0044242;multicellular organismal reproductive process#GO:0048609;organic substance metabolic process#GO:0071704;germ cell development#GO:0007281;organic acid biosynthetic process#GO:0016053;sperm capacitation#GO:0048240;oxoacid metabolic process#GO:0043436;cellular developmental process#GO:0048869;gamete generation#GO:0007276;cellular response to endogenous stimulus#GO:0071495;monocarboxylic acid biosynthetic process#GO:0072330;cellular response to organic substance#GO:0071310;cellular metabolic process#GO:0044237;cell communication#GO:0007154;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;developmental process involved in reproduction#GO:0003006;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;reproduction#GO:0000003;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;sexual reproduction#GO:0019953;multicellular organismal process#GO:0032501;small molecule biosynthetic process#GO:0044283;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329;lipid metabolic process#GO:0006629;signal transduction#GO:0007165;response to organic cyclic compound#GO:0014070;cellular process involved in reproduction in multicellular organism#GO:0022412;cellular response to steroid hormone stimulus#GO:0071383;developmental process#GO:0032502;response to lipid#GO:0033993;spermatid differentiation#GO:0048515;biosynthetic process#GO:0009058;cellular response to lipid#GO:0071396;acylglycerol catabolic process#GO:0046464;cell differentiation#GO:0030154;response to endogenous stimulus#GO:0009719;glycerolipid metabolic process#GO:0046486;cellular response to organic cyclic compound#GO:0071407;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;signaling#GO:0023052;metabolic process#GO:0008152;fatty acid biosynthetic process#GO:0006633;cellular catabolic process#GO:0044248;response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;multicellular organism reproduction#GO:0032504;cellular biosynthetic process#GO:0044249;steroid hormone mediated signaling pathway#GO:0043401;organic substance biosynthetic process#GO:1901576;glycerolipid catabolic process#GO:0046503;cellular process#GO:0009987;fatty acid catabolic process#GO:0009062;cell development#GO:0048468;spermatid development#GO:0007286;response to stimulus#GO:0050896;fatty acid metabolic process#GO:0006631;response to hormone#GO:0009725;response to chemical#GO:0042221;biological regulation#GO:0065007;cellular lipid metabolic process#GO:0044255;carboxylic acid metabolic process#GO:0019752;response to steroid hormone#GO:0048545 motile cilium#GO:0031514;9+2 motile cilium#GO:0097729;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;cell periphery#GO:0071944;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;cilium#GO:0005929;sperm flagellum#GO:0036126;plasma membrane#GO:0005886 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG111140|UniProtKB=T1EF87 T1EF87 20195239 PTHR23429:SF7 GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD GDH_6PGL ENDOPLASMIC BIFUNCTIONAL PROTEIN oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 cellular aromatic compound metabolic process#GO:0006725;monosaccharide metabolic process#GO:0005996;carbohydrate derivative metabolic process#GO:1901135;pyridine nucleotide metabolic process#GO:0019362;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;carbohydrate metabolic process#GO:0005975;NADP metabolic process#GO:0006739;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;organonitrogen compound metabolic process#GO:1901564;nicotinamide nucleotide metabolic process#GO:0046496;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;glucose metabolic process#GO:0006006;glucose 6-phosphate metabolic process#GO:0051156;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;hexose metabolic process#GO:0019318;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG182781|UniProtKB=T1FIQ2 T1FIQ2 20208701 PTHR10155:SF32 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT LP02169P enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;phosphatidylinositol 3-kinase complex#GO:0005942;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;membrane#GO:0016020;transferase complex, transferring phosphorus-containing groups#GO:0061695;extrinsic component of membrane#GO:0019898 kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG66220|UniProtKB=T1FYI6 T1FYI6 20213884 PTHR31107:SF2 APOPTOGENIC PROTEIN 1, MITOCHONDRIAL CYTOCHROME C OXIDASE ASSEMBLY FACTOR 8 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG172460|UniProtKB=T1F5C8 T1F5C8 20204027 PTHR22765:SF416 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE GODZILLA transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG157540|UniProtKB=T1EMC9 T1EMC9 20197729 PTHR46126:SF1 DYNACTIN SUBUNIT 5 DYNACTIN SUBUNIT 5 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG168148|UniProtKB=T1F081 T1F081 20202231 PTHR47577:SF2 THAP DOMAIN-CONTAINING PROTEIN 6 THAP DOMAIN CONTAINING 9 HELRO|EnsemblGenome=HelroG162640|UniProtKB=T1ESY7 T1ESY7 20199687 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG102708|UniProtKB=T1EDB1 T1EDB1 20194563 PTHR46961:SF17 DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN AAA+ ATPASE DOMAIN-CONTAINING PROTEIN microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG169179|UniProtKB=T1F1J1 T1F1J1 20202691 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG158457|UniProtKB=T1EMT4 T1EMT4 20197884 PTHR47972:SF28 KINESIN-LIKE PROTEIN KLP-3 KINESIN-LIKE PROTEIN KLP-3 cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 cellular process#GO:0009987;microtubule-based process#GO:0007017 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG169725|UniProtKB=T1F2A0 T1F2A0 20202950 PTHR45721:SF11 LAMIN DM0-RELATED LAMIN DM0-RELATED FAS signaling pathway#P00020>Nuclear Lamin#P00616 HELRO|EnsemblGenome=HelroG181437|UniProtKB=T1FH03 T1FH03 20208102 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG175054|UniProtKB=T1F8S6 T1F8S6 20205225 PTHR11733:SF133 ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED PHOSPHATE-REGULATING NEUTRAL ENDOPEPTIDASE PHEX hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Endothelin signaling pathway#P00019>ECE1-3#P00585 HELRO|EnsemblGenome=HelroG176735|UniProtKB=T1FAU8 T1FAU8 20205947 PTHR13512:SF2 MEDIATOR COMPLEX SUBUNIT 28 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 28 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mediator complex#GO:0016592;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG156389|UniProtKB=T1ELV2 T1ELV2 20197552 PTHR33668:SF1 PROTEIN BRICK1 PROTEIN BRICK1 regulation of anatomical structure size#GO:0090066;regulation of actin filament length#GO:0030832;regulation of organelle organization#GO:0033043;regulation of actin filament organization#GO:0110053;regulation of cellular component organization#GO:0051128;cellular component organization#GO:0016043;cell motility#GO:0048870;cellular process#GO:0009987;regulation of actin polymerization or depolymerization#GO:0008064;regulation of cellular component size#GO:0032535;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cytoskeleton organization#GO:0051493;regulation of biological quality#GO:0065008;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament-based process#GO:0032970 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG72856|UniProtKB=T1G161 T1G161 20214809 PTHR10582:SF28 TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN NANCHUNG, ISOFORM B calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;inorganic cation transmembrane transporter activity#GO:0022890;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;calcium ion transport#GO:0006816;localization#GO:0051179;calcium ion import#GO:0070509;import across plasma membrane#GO:0098739;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;calcium ion transmembrane import into cytosol#GO:0097553;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG89947|UniProtKB=T1G7J4 T1G7J4 20217041 PTHR23253:SF9 EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2 nucleic acid binding#GO:0003676;translation regulator activity#GO:0045182;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation initiation factor activity#GO:0003743;mRNA binding#GO:0003729;translation regulator activity, nucleic acid binding#GO:0090079;translation factor activity, RNA binding#GO:0008135 cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG162732|UniProtKB=T1ET25 T1ET25 20199725 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171012|UniProtKB=T1F3P6 T1F3P6 20203445 PTHR22878:SF63 DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED DYNEIN AXONEMAL HEAVY CHAIN 10 Huntington disease#P00029>Dynein complex#P00774 HELRO|EnsemblGenome=HelroG88195|UniProtKB=T1G6Z7 T1G6Z7 20216844 PTHR11920:SF501 GUANYLYL CYCLASE GUANYLATE CYCLASE 32E adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG180128|UniProtKB=T1FFH9 T1FFH9 20207578 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG148954|UniProtKB=T1EKC2 T1EKC2 20197022 PTHR10037:SF230 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM CA[2+]-CHANNEL PROTEIN ALPHA[[1]] SUBUNIT T, ISOFORM F calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;voltage-gated channel activity#GO:0022832;sodium ion transmembrane transporter activity#GO:0015081;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated calcium channel activity#GO:0005245;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 localization#GO:0051179;calcium ion import#GO:0070509;metal ion transport#GO:0030001;establishment of localization#GO:0051234;regulation of biological quality#GO:0065008;membrane depolarization#GO:0051899;transport#GO:0006810;regulation of membrane potential#GO:0042391;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;action potential#GO:0001508;monoatomic ion transport#GO:0006811;calcium ion transport#GO:0006816 membrane protein complex#GO:0098796;sodium channel complex#GO:0034706;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron projection#GO:0043005;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell projection#GO:0042995;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG160934|UniProtKB=T1EQV6 T1EQV6 20198956 PTHR23107:SF34 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN HTH LA-TYPE RNA-BINDING DOMAIN-CONTAINING PROTEIN transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG150157|UniProtKB=T1EKE5 T1EKE5 20197045 PTHR46006:SF8 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A DH DOMAIN-CONTAINING PROTEIN regulation of cell communication#GO:0010646;regulation of Rho protein signal transduction#GO:0035023;positive regulation of signal transduction#GO:0009967;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of small GTPase mediated signal transduction#GO:0051056;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;positive regulation of cell communication#GO:0010647;biological regulation#GO:0065007;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG77423|UniProtKB=T1G2X5 T1G2X5 20215423 PTHR13423:SF2 OUT AT FIRST OUT AT FIRST PROTEIN HOMOLOG HELRO|EnsemblGenome=HelroG116111|UniProtKB=T1EGD1 T1EGD1 20195633 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-LIKE 1 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;localization#GO:0051179;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 membrane protein complex#GO:0098796;synapse#GO:0045202;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron projection#GO:0043005;transmembrane transporter complex#GO:1902495;cell projection#GO:0042995;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HELRO|EnsemblGenome=HelroG62307|UniProtKB=T1FWZ2 T1FWZ2 20213340 PTHR24637:SF388 COLLAGEN NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG84811|UniProtKB=T1G5N9 T1G5N9 20216386 PTHR46197:SF3 PROTEIN ABHD14B-LIKE AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG170601|UniProtKB=T1F383 T1F383 20203282 PTHR31542:SF1 39A RIBOSOMAL PROTEIN L50, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN ML50 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrial large ribosomal subunit#GO:0005762;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;organellar ribosome#GO:0000313;protein-containing complex#GO:0032991;large ribosomal subunit#GO:0015934;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840;mitochondrial protein-containing complex#GO:0098798 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG182144|UniProtKB=T1FHT7 T1FHT7 20208386 PTHR47522:SF2 SALVADOR FAMILY WW DOMAIN-CONTAINING PROTEIN 1 PROTEIN SALVADOR HOMOLOG 1 positive regulation of apoptotic process#GO:0043065;signal transduction#GO:0007165;negative regulation of biological process#GO:0048519;cellular response to stimulus#GO:0051716;regulation of apoptotic process#GO:0042981;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;hippo signaling#GO:0035329;response to stimulus#GO:0050896;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;negative regulation of cell population proliferation#GO:0008285;intracellular signal transduction#GO:0035556;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;positive regulation of biological process#GO:0048518;regulation of programmed cell death#GO:0043067 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG75596|UniProtKB=T1G269 T1G269 20215167 PTHR10113:SF10 PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1 EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1 translation release factor#PC00225;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG192269|UniProtKB=T1FTS2 T1FTS2 20212219 PTHR13612:SF0 ENHANCER OF MRNA-DECAPPING PROTEIN 3 ENHANCER OF MRNA-DECAPPING PROTEIN 3 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;negative regulation of cellular metabolic process#GO:0031324;cellular component biogenesis#GO:0044085;negative regulation of biological process#GO:0048519;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;regulation of biological process#GO:0050789;RNA decapping#GO:0110154;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;mRNA catabolic process#GO:0006402;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;P-body assembly#GO:0033962;non-membrane-bounded organelle assembly#GO:0140694;negative regulation of cellular process#GO:0048523;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;nuclear-transcribed mRNA catabolic process#GO:0000956;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;regulation of cellular biosynthetic process#GO:0031326;aromatic compound catabolic process#GO:0019439;regulation of macromolecule metabolic process#GO:0060255;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;P-body#GO:0000932;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic ribonucleoprotein granule#GO:0036464 HELRO|EnsemblGenome=HelroG182783|UniProtKB=T1FIQ3 T1FIQ3 20208702 PTHR21224:SF1 INTEGRATOR COMPLEX SUBUNIT 1 INTEGRATOR COMPLEX SUBUNIT 1 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;snRNA metabolic process#GO:0016073;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;snRNA 3'-end processing#GO:0034472;snRNA processing#GO:0016180;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;integrator complex#GO:0032039 HELRO|EnsemblGenome=HelroG162034|UniProtKB=T1ES61 T1ES61 20199411 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG111980|UniProtKB=T1EFG2 T1EFG2 20195314 PTHR31148:SF1 U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C nucleic acid binding#GO:0003676;RNA binding#GO:0003723;pre-mRNA binding#GO:0036002;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;mRNA cis splicing, via spliceosome#GO:0045292;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;mRNA splice site recognition#GO:0006376;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375;spliceosomal complex assembly#GO:0000245 ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;U1 snRNP#GO:0005685;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG115371|UniProtKB=T1EG77 T1EG77 20195579 PTHR11096:SF1 RNA 3' TERMINAL PHOSPHATE CYCLASE RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;ligase activity#GO:0016874;cyclase activity#GO:0009975;nuclease activity#GO:0004518;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;ribosome biogenesis#GO:0042254;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG90349|UniProtKB=T1G7P5 T1G7P5 20217092 PTHR13049:SF2 DUF814-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN 25 HELRO|EnsemblGenome=HelroG185631|UniProtKB=T1FN25 T1FN25 20210224 PTHR43503:SF4 MCG48959-RELATED PEROXIREDOXIN-6 homeostatic process#GO:0042592;cellular homeostasis#GO:0019725 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 peroxidase#PC00180;oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG192996|UniProtKB=T1FUH8 T1FUH8 20212474 PTHR13140:SF713 MYOSIN UNCONVENTIONAL MYOSIN ID microfilament motor activity#GO:0000146;cytoskeletal protein binding#GO:0008092;ATP-dependent activity#GO:0140657;binding#GO:0005488;actin filament binding#GO:0051015;cytoskeletal motor activity#GO:0003774;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779 actin filament-based movement#GO:0030048;transport#GO:0006810;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;establishment of localization#GO:0051234;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;import into cell#GO:0098657 microvillus#GO:0005902;actin-based cell projection#GO:0098858;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cell projection#GO:0042995;plasma membrane#GO:0005886 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG78376|UniProtKB=T1G3B2 T1G3B2 20215560 PTHR24416:SF580 TYROSINE-PROTEIN KINASE RECEPTOR DISCOIDIN DOMAIN RECEPTOR, ISOFORM F signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888;transferase activity#GO:0016740;transmembrane receptor protein kinase activity#GO:0019199;collagen binding#GO:0005518;molecular transducer activity#GO:0060089;protein-containing complex binding#GO:0044877;catalytic activity, acting on a protein#GO:0140096 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;regulation of cellular component organization#GO:0051128;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;regulation of plasma membrane bounded cell projection organization#GO:0120035;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;regulation of neuron projection development#GO:0010975;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;anatomical structure development#GO:0048856;regulation of cell projection organization#GO:0031344;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG72659|UniProtKB=T1G134 T1G134 20214782 PTHR24302:SF15 CYTOCHROME P450 FAMILY 3 FATTY-ACID PEROXYGENASE oxygenase#PC00177;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG145646|UniProtKB=T1EJL6 T1EJL6 20196766 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN SI:DKEY-17M8.2 HELRO|EnsemblGenome=HelroG161106|UniProtKB=T1ER37 T1ER37 20199037 PTHR23050:SF518 CALCIUM BINDING PROTEIN AT16150P-RELATED cation binding#GO:0043169;small molecule binding#GO:0036094;molecular function regulator activity#GO:0098772;binding#GO:0005488;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;enzyme regulator activity#GO:0030234 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061 B cell activation#P00010>Calmodulin#P00375;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Calmodulin#P00755;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716;T cell activation#P00053>Calmodulin#P01305 HELRO|EnsemblGenome=HelroG192675|UniProtKB=T1FU64 T1FU64 20212360 PTHR21284:SF12 EG:80H7.2 PROTEIN EG:80H7.2 PROTEIN HELRO|EnsemblGenome=HelroG79114|UniProtKB=T1G3K3 T1G3K3 20215651 PTHR46337:SF1 RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN HELRO|EnsemblGenome=HelroG171372|UniProtKB=T1F471 T1F471 20203620 PTHR14732:SF0 RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG174443|UniProtKB=T1F847 T1F847 20204996 PTHR34491:SF150 A-TYPE INCLUSION PROTEIN, PUTATIVE-RELATED WASP-RELATED PROTEIN HELRO|EnsemblGenome=HelroG185385|UniProtKB=T1FMR1 T1FMR1 20210110 PTHR10687:SF2 SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN localization#GO:0051179;organic substance transport#GO:0071702;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;protein transport#GO:0015031;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 bounding membrane of organelle#GO:0098588;trans-Golgi network#GO:0005802;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;trans-Golgi network membrane#GO:0032588;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;recycling endosome membrane#GO:0055038;organelle#GO:0043226;endosome membrane#GO:0010008;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;recycling endosome#GO:0055037;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791;cytoplasmic vesicle membrane#GO:0030659 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG163155|UniProtKB=T1ETQ7 T1ETQ7 20199957 PTHR16213:SF78 SELENOPROTEIN N SELENOPROTEIN N skeletal muscle organ development#GO:0060538;inorganic ion homeostasis#GO:0098771;cellular developmental process#GO:0048869;muscle organ development#GO:0007517;muscle cell differentiation#GO:0042692;calcium ion homeostasis#GO:0055074;animal organ development#GO:0048513;developmental process#GO:0032502;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;cellular process#GO:0009987;tissue development#GO:0009888;muscle tissue development#GO:0060537;monoatomic ion homeostasis#GO:0050801;muscle cell development#GO:0055001;cell development#GO:0048468;muscle structure development#GO:0061061;cell differentiation#GO:0030154;striated muscle cell differentiation#GO:0051146;anatomical structure development#GO:0048856;skeletal muscle tissue development#GO:0007519 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG178474|UniProtKB=T1FD81 T1FD81 20206780 PTHR46123:SF4 MIX-TYPE HOMEOBOX GENE 1-RELATED MIX-TYPE HOMEOBOX GENE 1-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG193420|UniProtKB=T1FUZ0 T1FUZ0 20212636 PTHR45990:SF1 DNA REPAIR PROTEIN REV1 DNA REPAIR PROTEIN REV1 DNA-directed DNA polymerase activity#GO:0003887;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on DNA#GO:0140097;DNA polymerase activity#GO:0034061 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;postreplication repair#GO:0006301;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;translesion synthesis#GO:0019985;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;nucleobase-containing compound biosynthetic process#GO:0034654;DNA biosynthetic process#GO:0071897;DNA synthesis involved in DNA repair#GO:0000731;aromatic compound biosynthetic process#GO:0019438;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG82214|UniProtKB=T1G4P3 T1G4P3 20216041 PTHR44170:SF56 PROTEIN SIDEKICK FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987 cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG133636|UniProtKB=T1EI19 T1EI19 20196219 PTHR24416:SF564 TYROSINE-PROTEIN KINASE RECEPTOR MACROPHAGE-STIMULATING PROTEIN RECEPTOR signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;nervous system development#GO:0007399;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;system development#GO:0048731;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cell motility#GO:0048870;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;cell migration#GO:0016477;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG189498|UniProtKB=T1FR37 T1FR37 20211284 PTHR13140:SF706 MYOSIN DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C microfilament motor activity#GO:0000146;cytoskeletal protein binding#GO:0008092;ATP-dependent activity#GO:0140657;binding#GO:0005488;actin filament binding#GO:0051015;cytoskeletal motor activity#GO:0003774;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;membrane#GO:0016020;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG164616|UniProtKB=T1EVN1 T1EVN1 20200631 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167651|UniProtKB=T1EZM4 T1EZM4 20202024 PTHR46641:SF25 FMRFAMIDE RECEPTOR-RELATED CNMAMIDE RECEPTOR-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG170977|UniProtKB=T1F3N5 T1F3N5 20203434 PTHR11782:SF83 ADENOSINE/GUANOSINE DIPHOSPHATASE GUANOSINE-DIPHOSPHATASE pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;nucleoside diphosphate phosphatase activity#GO:0017110;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;nucleoside phosphate catabolic process#GO:1901292;heterocycle catabolic process#GO:0046700;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleoside diphosphate catabolic process#GO:0009134;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate catabolic process#GO:0046434;phosphate-containing compound metabolic process#GO:0006796;cellular nitrogen compound catabolic process#GO:0044270;aromatic compound catabolic process#GO:0019439;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;organic cyclic compound catabolic process#GO:1901361;catabolic process#GO:0009056;nucleoside diphosphate metabolic process#GO:0009132;organophosphate metabolic process#GO:0019637;organic substance catabolic process#GO:1901575;nucleobase-containing compound catabolic process#GO:0034655;small molecule metabolic process#GO:0044281;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248 cellular anatomical entity#GO:0110165;membrane#GO:0016020 metabolite interconversion enzyme#PC00262;phosphatase#PC00181;nucleotide phosphatase#PC00173 HELRO|EnsemblGenome=HelroG83198|UniProtKB=T1G518 T1G518 20216166 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN SI:DKEY-17M8.2 HELRO|EnsemblGenome=HelroG161766|UniProtKB=T1ERV8 T1ERV8 20199308 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG188509|UniProtKB=T1FQ28 T1FQ28 20210925 PTHR23104:SF17 MULTIPLE COAGULATION FACTOR DEFICIENCY PROTEIN 2 NEURAL STEM CELL DERIVED NEURONAL SURVIVAL PROTEIN EF-HAND DOMAIN-CONTAINING PROTEIN membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG158666|UniProtKB=T1EN38 T1EN38 20197988 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG67273|UniProtKB=T1FYZ2 T1FYZ2 20214040 PTHR28572:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 103 COILED-COIL DOMAIN-CONTAINING PROTEIN 103 cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cell projection organization#GO:0030030;transport#GO:0006810;developmental process#GO:0032502;inner dynein arm assembly#GO:0036159;microtubule cytoskeleton organization#GO:0000226;microtubule-based movement#GO:0007018;protein-containing complex assembly#GO:0065003;axoneme assembly#GO:0035082;plasma membrane bounded cell projection organization#GO:0120036;epithelial cilium movement involved in extracellular fluid movement#GO:0003351;establishment of localization#GO:0051234;determination of left/right symmetry#GO:0007368;cytoskeleton organization#GO:0007010;pattern specification process#GO:0007389;cellular component assembly#GO:0022607;cilium assembly#GO:0060271;left/right pattern formation#GO:0060972;multicellular organism development#GO:0007275;regionalization#GO:0003002;cellular component organization#GO:0016043;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium movement#GO:0003341;localization#GO:0051179;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based transport#GO:0099111;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;anatomical structure development#GO:0048856;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection assembly#GO:0120031 HELRO|EnsemblGenome=HelroG106357|UniProtKB=T1EE24 T1EE24 20194826 PTHR11255:SF48 DIACYLGLYCEROL KINASE DIACYLGLYCEROL KINASE 1 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301;lipid kinase activity#GO:0001727 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transferase#PC00220;kinase#PC00137;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG169917|UniProtKB=T1F2G0 T1F2G0 20203010 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG98264|UniProtKB=T1G9L5 T1G9L5 20217761 PTHR10314:SF194 CYSTATHIONINE BETA-SYNTHASE CYSTATHIONINE BETA-SYNTHASE transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;sulfur compound metabolic process#GO:0006790;proteinogenic amino acid biosynthetic process#GO:0170038;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;alpha-amino acid biosynthetic process#GO:1901607;nitrogen compound metabolic process#GO:0006807;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;small molecule biosynthetic process#GO:0044283;L-amino acid biosynthetic process#GO:0170034;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 lyase#PC00144 Cysteine biosynthesis#P02737>O-Acetylserine-lyase#P02887 HELRO|EnsemblGenome=HelroG162187|UniProtKB=T1ESC2 T1ESC2 20199472 PTHR23353:SF34 RAB-GAP/TBC-RELATED TBC1 DOMAIN FAMILY MEMBER 24 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 N-acetylglucosamine metabolism#P02756>N-acetylglucosamine-6-phosphate deacetylase#P03036 HELRO|EnsemblGenome=HelroG163725|UniProtKB=T1EUE5 T1EUE5 20200195 PTHR13261:SF0 BRCA2 AND CDKN1A INTERACTING PROTEIN BRCA2 AND CDKN1A-INTERACTING PROTEIN membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG97655|UniProtKB=T1G9I3 T1G9I3 20217730 PTHR11932:SF76 CULLIN CULLIN-5 enzyme binding#GO:0019899;molecular adaptor activity#GO:0060090;protein binding#GO:0005515;ubiquitin protein ligase binding#GO:0031625;binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389;protein-macromolecule adaptor activity#GO:0030674 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG178024|UniProtKB=T1FCM3 T1FCM3 20206572 PTHR38537:SF8 JITTERBUG, ISOFORM N FILAMIN-A HELRO|EnsemblGenome=HelroG160824|UniProtKB=T1EQS2 T1EQS2 20198922 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171817|UniProtKB=T1F4Q7 T1F4Q7 20203806 PTHR23107:SF34 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN HTH LA-TYPE RNA-BINDING DOMAIN-CONTAINING PROTEIN transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG169344|UniProtKB=T1F1T1 T1F1T1 20202781 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG116577|UniProtKB=T1EGG2 T1EGG2 20195664 PTHR10185:SF17 PHOSPHOLIPASE D - RELATED GM01519P-RELATED phospholipase#PC00186 HELRO|EnsemblGenome=HelroG139434|UniProtKB=T1EIY8 T1EIY8 20196538 PTHR22762:SF54 ALPHA-GLUCOSIDASE BCDNA.GH04962 hydrolase activity#GO:0016787;glucosidase activity#GO:0015926;hydrolase activity, acting on glycosyl bonds#GO:0016798;alpha-glucosidase activity#GO:0090599;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 carbohydrate derivative metabolic process#GO:1901135;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 glucosidase#PC00108;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG78585|UniProtKB=T1G3D4 T1G3D4 20215582 PTHR12403:SF1 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2-RELATED localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;vesicle tethering complex#GO:0099023;TRAPP complex#GO:0030008;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG88788|UniProtKB=T1G765 T1G765 20216912 PTHR22958:SF1 GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1 lipid metabolic process#GO:0006629;cellular metabolic process#GO:0044237;glycerophospholipid metabolic process#GO:0006650;glycerolipid catabolic process#GO:0046503;glycerophospholipid catabolic process#GO:0046475;lipid catabolic process#GO:0016042;cellular process#GO:0009987;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;organophosphate catabolic process#GO:0046434;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;phospholipid catabolic process#GO:0009395;catabolic process#GO:0009056;organophosphate metabolic process#GO:0019637;organic substance catabolic process#GO:1901575;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 phosphodiesterase#PC00185;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG87998|UniProtKB=T1G6X2 T1G6X2 20216819 PTHR10465:SF3 TRANSMEMBRANE GTPASE FZO1 TRANSMEMBRANE GTPASE MARF-RELATED GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 localization#GO:0051179;mitochondrial fusion#GO:0008053;cellular component organization or biogenesis#GO:0071840;organelle localization#GO:0051640;organelle organization#GO:0006996;cellular component organization#GO:0016043;mitochondrion organization#GO:0007005;cellular process#GO:0009987;organelle fusion#GO:0048284 envelope#GO:0031975;bounding membrane of organelle#GO:0098588;mitochondrial membrane#GO:0031966;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867 HELRO|EnsemblGenome=HelroG116477|UniProtKB=T1EGF3 T1EGF3 20195655 PTHR10414:SF37 ETHANOLAMINEPHOSPHOTRANSFERASE BB IN A BOXCAR, ISOFORM C transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG159966|UniProtKB=T1EPL8 T1EPL8 20198518 PTHR22811:SF218 TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN GOLD DOMAIN-CONTAINING PROTEIN endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;Golgi organization#GO:0007030;macromolecule localization#GO:0033036;transport#GO:0006810;endomembrane system organization#GO:0010256;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;organelle organization#GO:0006996;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;endoplasmic reticulum#GO:0005783;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG132330|UniProtKB=T1EHX8 T1EHX8 20196178 PTHR24247:SF265 5-HYDROXYTRYPTAMINE RECEPTOR MUSCARINIC ACETYLCHOLINE RECEPTOR DM1 signaling receptor activity#GO:0038023;G protein-coupled amine receptor activity#GO:0008227;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 response to organic substance#GO:0010033;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to nitrogen compound#GO:1901699;response to nitrogen compound#GO:1901698;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to oxygen-containing compound#GO:1901701;chemical synaptic transmission#GO:0007268;response to chemical#GO:0042221;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;synaptic signaling#GO:0099536;G protein-coupled receptor signaling pathway#GO:0007186;cell-cell signaling#GO:0007267;signaling#GO:0023052;acetylcholine receptor signaling pathway#GO:0095500 synapse#GO:0045202;somatodendritic compartment#GO:0036477;neuron projection#GO:0043005;cell junction#GO:0030054;dendrite#GO:0030425;cell projection#GO:0042995;cell periphery#GO:0071944;dendritic tree#GO:0097447;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GqPCR#P00730 HELRO|EnsemblGenome=HelroG113060|UniProtKB=T1EFQ0 T1EFQ0 20195402 PTHR13768:SF8 SOLUBLE NSF ATTACHMENT PROTEIN SNAP ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN syntaxin binding#GO:0019905;molecular adaptor activity#GO:0060090;protein binding#GO:0005515;binding#GO:0005488;SNARE binding#GO:0000149;protein-macromolecule adaptor activity#GO:0030674 cellular localization#GO:0051641;protein-containing complex disassembly#GO:0032984;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;cellular component disassembly#GO:0022411;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein-containing complex organization#GO:0043933;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;vacuolar membrane#GO:0005774;SNARE complex#GO:0031201;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG190223|UniProtKB=T1FRS4 T1FRS4 20211521 PTHR19282:SF515 TETRASPANIN TETRASPANIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG164746|UniProtKB=T1EVR8 T1EVR8 20200668 PTHR42264:SF3 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN F-BOX DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG170464|UniProtKB=T1F336 T1F336 20203235 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG171072|UniProtKB=T1F3S3 T1F3S3 20203472 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG165169|UniProtKB=T1EWD2 T1EWD2 20200882 PTHR13817:SF172 TITIN IG-LIKE DOMAIN-CONTAINING PROTEIN structural protein#PC00211 Axon guidance mediated by Slit/Robo#P00008>Robo#P00348 HELRO|EnsemblGenome=HelroG164073|UniProtKB=T1EUV8 T1EUV8 20200358 PTHR46880:SF5 RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190316|UniProtKB=T1FRW4 T1FRW4 20211561 PTHR13663:SF2 SIMILAR TO RIKEN CDNA 6430548M08 SIMILAR TO RIKEN CDNA 6430548M08 HELRO|EnsemblGenome=HelroG119465|UniProtKB=T1EGN3 T1EGN3 20195733 PTHR10352:SF79 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G TRIVET, ISOFORM I translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG70423|UniProtKB=T1G065 T1G065 20214463 PTHR11893:SF36 INNEXIN INNEXIN-5 cell junction protein#PC00070;gap junction#PC00105 HELRO|EnsemblGenome=HelroG180787|UniProtKB=T1FGA0 T1FGA0 20207849 PTHR12231:SF253 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED immunoglobulin superfamily cell adhesion molecule#PC00125 HELRO|EnsemblGenome=HelroG165444|UniProtKB=T1EWT1 T1EWT1 20201031 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171300|UniProtKB=T1F421 T1F421 20203570 PTHR24104:SF57 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED BEE-MILK PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG182307|UniProtKB=T1FI12 T1FI12 20208461 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179462|UniProtKB=T1FER2 T1FER2 20207311 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG160268|UniProtKB=T1EQ12 T1EQ12 20198662 PTHR15830:SF10 TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;telomeric DNA binding#GO:0042162;heat shock protein binding#GO:0031072;protein binding#GO:0005515;Hsp90 protein binding#GO:0051879 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;'de novo' protein folding#GO:0006458;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG65192|UniProtKB=T1FY45 T1FY45 20213743 PTHR45777:SF2 METHIONINE AMINOPEPTIDASE 2 METHIONINE AMINOPEPTIDASE 2 metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;aminopeptidase activity#GO:0004177;exopeptidase activity#GO:0008238;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 protease#PC00190 HELRO|EnsemblGenome=HelroG193091|UniProtKB=T1FUM2 T1FUM2 20212518 PTHR35270:SF2 FUSELESS, ISOFORM A FUSELESS, ISOFORM A HELRO|EnsemblGenome=HelroG180974|UniProtKB=T1FGH1 T1FGH1 20207920 PTHR21461:SF69 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 glycosylation#GO:0070085;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG191341|UniProtKB=T1FSW7 T1FSW7 20211914 PTHR21567:SF87 CLASP CRESCERIN-LIKE PROTEIN CHE-12 cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule-based process#GO:0007017;organelle organization#GO:0006996 supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cytoplasmic microtubule#GO:0005881;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG63958|UniProtKB=T1FXM8 T1FXM8 20213576 PTHR15454:SF35 NISCHARIN RELATED NISCHARIN cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG107263|UniProtKB=T1EE92 T1EE92 20194894 PTHR45716:SF2 BITESIZE, ISOFORM I BITESIZE, ISOFORM I protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 localization#GO:0051179;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;export from cell#GO:0140352;secretion by cell#GO:0032940 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG180154|UniProtKB=T1FFJ1 T1FFJ1 20207590 PTHR46518:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 151 OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 3 cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;outer dynein arm assembly#GO:0036158;cell projection organization#GO:0030030;microtubule cytoskeleton organization#GO:0000226;microtubule-based movement#GO:0007018;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;axoneme assembly#GO:0035082;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;cilium movement#GO:0003341;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection assembly#GO:0120031 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;cilium#GO:0005929;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG192998|UniProtKB=T1FUH9 T1FUH9 20212475 PTHR11215:SF1 METAL DEPENDENT HYDROLASE - RELATED MYG1 EXONUCLEASE metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG100634|UniProtKB=T1ED09 T1ED09 20194461 PTHR11893:SF36 INNEXIN INNEXIN-5 cell junction protein#PC00070;gap junction#PC00105 HELRO|EnsemblGenome=HelroG174576|UniProtKB=T1F897 T1F897 20205046 PTHR10283:SF82 SOLUTE CARRIER FAMILY 13 MEMBER SOLUTE CARRIER FAMILY 13 MEMBER 2 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG194686|UniProtKB=T1FWB5 T1FWB5 20213111 PTHR23220:SF122 INTEGRIN ALPHA INTEGRIN ALPHA-PS1 cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;integrin binding#GO:0005178;binding#GO:0005488;signaling receptor binding#GO:0005102 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;cell adhesion mediated by integrin#GO:0033627;cell-cell adhesion#GO:0098609;cell communication#GO:0007154;cell adhesion#GO:0007155;cell-substrate adhesion#GO:0031589;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cell-matrix adhesion#GO:0007160;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;integrin-mediated signaling pathway#GO:0007229;biological regulation#GO:0065007;signaling#GO:0023052 receptor complex#GO:0043235;membrane protein complex#GO:0098796;external side of plasma membrane#GO:0009897;cell surface#GO:0009986;protein-containing complex#GO:0032991;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;side of membrane#GO:0098552;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;integrin#PC00126 Integrin signalling pathway#P00034>Integrin alpha#P00941 HELRO|EnsemblGenome=HelroG191620|UniProtKB=T1FT49 T1FT49 20211996 PTHR45984:SF1 RNA (RNA) POLYMERASE II ASSOCIATED PROTEIN HOMOLOG SPAG1 AXONEMAL DYNEIN ASSEMBLY FACTOR protein binding#GO:0005515;heat shock protein binding#GO:0031072;binding#GO:0005488 localization#GO:0051179;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;protein targeting to mitochondrion#GO:0006626;establishment of localization#GO:0051234;establishment of protein localization to mitochondrion#GO:0072655;protein targeting#GO:0006605;establishment of protein localization to organelle#GO:0072594;protein localization to organelle#GO:0033365;cellular process#GO:0009987;protein localization to mitochondrion#GO:0070585;establishment of protein localization#GO:0045184;protein localization#GO:0008104 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185164|UniProtKB=T1FMG7 T1FMG7 20210016 PTHR36300:SF1 RAW, ISOFORM A RAW, ISOFORM A cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG82086|UniProtKB=T1G4M6 T1G4M6 20216024 PTHR10024:SF227 SYNAPTOTAGMIN SYNAPTOTAGMIN 1 cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;phosphatidylserine binding#GO:0001786;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;protein binding#GO:0005515;clathrin binding#GO:0030276;lipid binding#GO:0008289;ion binding#GO:0043167;phospholipid binding#GO:0005543;SNARE binding#GO:0000149 cellular localization#GO:0051641;synaptic vesicle cycle#GO:0099504;synaptic vesicle endocytosis#GO:0048488;transport#GO:0006810;regulation of biological process#GO:0050789;regulated exocytosis#GO:0045055;synaptic vesicle recycling#GO:0036465;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;secretion#GO:0046903;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;signal release#GO:0023061;calcium-ion regulated exocytosis#GO:0017156;cell-cell signaling#GO:0007267;signaling#GO:0023052;synaptic vesicle exocytosis#GO:0016079;secretion by cell#GO:0032940;neurotransmitter secretion#GO:0007269;endocytosis#GO:0006897;trans-synaptic signaling#GO:0099537;vesicle-mediated transport#GO:0016192;cell communication#GO:0007154;cellular process#GO:0009987;localization#GO:0051179;signal release from synapse#GO:0099643;exocytosis#GO:0006887;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;import into cell#GO:0098657;export from cell#GO:0140352;vesicle-mediated transport in synapse#GO:0099003 intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;secretory vesicle#GO:0099503;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG181161|UniProtKB=T1FGP2 T1FGP2 20207991 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG93645|UniProtKB=T1G8X1 T1G8X1 20217518 PTHR10984:SF30 ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 2 localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;establishment of localization#GO:0051234;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;transport#GO:0006810;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193 cytoplasm#GO:0005737;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG166059|UniProtKB=T1EXN6 T1EXN6 20201336 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG80203|UniProtKB=T1G3Y7 T1G3Y7 20215785 PTHR24349:SF514 SERINE/THREONINE-PROTEIN KINASE MAP KINASE-ACTIVATED PROTEIN KINASE 2 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein serine/threonine kinase activity#GO:0004674;protein binding#GO:0005515;calmodulin binding#GO:0005516;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Ras Pathway#P04393>MAPKAP#P04564;PDGF signaling pathway#P00047>MAPKAPK2#P01157;VEGF signaling pathway#P00056>MAPKAPK2/3#P01415;Angiogenesis#P00005>MAPKAPK2/3#P00244 HELRO|EnsemblGenome=HelroG103086|UniProtKB=T1EDE2 T1EDE2 20194594 PTHR10763:SF23 CELL DIVISION CONTROL PROTEIN 6-RELATED ORIGIN RECOGNITION COMPLEX SUBUNIT 1 sequence-specific double-stranded DNA binding#GO:1990837;DNA replication origin binding#GO:0003688;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 cellular aromatic compound metabolic process#GO:0006725;negative regulation of biological process#GO:0048519;signal transduction#GO:0007165;mitotic cell cycle checkpoint signaling#GO:0007093;cell cycle process#GO:0022402;negative regulation of cell cycle process#GO:0010948;nucleobase-containing compound metabolic process#GO:0006139;mitotic cell cycle process#GO:1903047;regulation of biological process#GO:0050789;cell cycle checkpoint signaling#GO:0000075;negative regulation of mitotic cell cycle phase transition#GO:1901991;mitotic cell cycle#GO:0000278;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;DNA-templated DNA replication#GO:0006261;mitotic DNA replication checkpoint signaling#GO:0033314;intracellular signal transduction#GO:0035556;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;regulation of cell cycle G2/M phase transition#GO:1902749;negative regulation of cell cycle G2/M phase transition#GO:1902750;regulation of mitotic cell cycle phase transition#GO:1901990;macromolecule metabolic process#GO:0043170;negative regulation of cell cycle#GO:0045786;regulation of cell cycle phase transition#GO:1901987;negative regulation of cell cycle phase transition#GO:1901988;cellular metabolic process#GO:0044237;cell communication#GO:0007154;negative regulation of mitotic cell cycle#GO:0045930;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;regulation of cell cycle process#GO:0010564;response to stimulus#GO:0050896;DNA integrity checkpoint signaling#GO:0031570;nucleic acid metabolic process#GO:0090304;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;DNA replication checkpoint signaling#GO:0000076;regulation of cellular process#GO:0050794;mitotic G2/M transition checkpoint#GO:0044818;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of G2/M transition of mitotic cell cycle#GO:0010389;mitotic DNA integrity checkpoint signaling#GO:0044774;DNA replication#GO:0006260;DNA replication initiation#GO:0006270;regulation of mitotic cell cycle#GO:0007346;DNA metabolic process#GO:0006259 origin recognition complex#GO:0000808;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;nuclear origin of replication recognition complex#GO:0005664;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 DNA metabolism protein#PC00009;replication origin binding protein#PC00199 HELRO|EnsemblGenome=HelroG159919|UniProtKB=T1EPJ9 T1EPJ9 20198499 PTHR24058:SF17 DUAL SPECIFICITY PROTEIN KINASE HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;peptidyl-threonine phosphorylation#GO:0018107;nitrogen compound metabolic process#GO:0006807;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191443|UniProtKB=T1FSZ8 T1FSZ8 20211945 PTHR10117:SF54 TRANSIENT RECEPTOR POTENTIAL CHANNEL TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;small molecule binding#GO:0036094;binding#GO:0005488;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;anion binding#GO:0043168;ion binding#GO:0043167;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;alcohol binding#GO:0043178 inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;regulation of cytosolic calcium ion concentration#GO:0051480;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;calcium ion transport#GO:0006816;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 Alzheimer disease-presenilin pathway#P00004>Capacitative calcium channels#P00124 HELRO|EnsemblGenome=HelroG173789|UniProtKB=T1F783 T1F783 20204682 PTHR18952:SF141 CARBONIC ANHYDRASE CARBONIC ANHYDRASE carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG171168|UniProtKB=T1F3W3 T1F3W3 20203512 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG191785|UniProtKB=T1FTB6 T1FTB6 20212063 PTHR11412:SF136 MACROGLOBULIN / COMPLEMENT CD109 ANTIGEN protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG191296|UniProtKB=T1FSU9 T1FSU9 20211896 PTHR13556:SF2 TRANSCRIPTIONAL ADAPTER 3-RELATED TRANSCRIPTIONAL ADAPTER 3 transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 SAGA-type complex#GO:0070461;peptidase complex#GO:1905368;histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;chromosome#GO:0005694;SAGA complex#GO:0000124 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG159904|UniProtKB=T1EPJ2 T1EPJ2 20198492 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG184962|UniProtKB=T1FM75 T1FM75 20209924 PTHR11073:SF1 CALRETICULIN AND CALNEXIN CALNEXIN 14D-RELATED cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 protein catabolic process#GO:0030163;gene expression#GO:0010467;organonitrogen compound catabolic process#GO:1901565;biosynthetic process#GO:0009058;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;macromolecule catabolic process#GO:0009057;response to endoplasmic reticulum stress#GO:0034976;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;protein maturation#GO:0051604;ERAD pathway#GO:0036503;cellular biosynthetic process#GO:0044249;response to organonitrogen compound#GO:0010243;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;protein folding#GO:0006457;cellular response to stress#GO:0033554 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG187347|UniProtKB=T1FP91 T1FP91 20210638 PTHR11937:SF14 ACTIN ACTIN-RELATED PROTEIN 10 microtubule-based movement#GO:0007018;cellular process#GO:0009987;microtubule-based process#GO:0007017 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 actin and actin related protein#PC00039;cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG181629|UniProtKB=T1FH69 T1FH69 20208168 PTHR10390:SF33 HOMEOBOX PROTEIN SIX PROTEIN OPTIX sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG159142|UniProtKB=T1ENN4 T1ENN4 20198184 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG85437|UniProtKB=T1G5X1 T1G5X1 20216468 PTHR10334:SF498 CYSTEINE-RICH SECRETORY PROTEIN-RELATED MIP16674P defense/immunity protein#PC00090 PI3 kinase pathway#P00048>scl-1#G01545 HELRO|EnsemblGenome=HelroG193782|UniProtKB=T1FVC7 T1FVC7 20212773 PTHR23339:SF98 TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE PRL-1 PHOSPHATASE protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG177393|UniProtKB=T1FBM0 T1FBM0 20206219 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG65100|UniProtKB=T1FY33 T1FY33 20213731 PTHR23077:SF171 AAA-FAMILY ATPASE NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE pyrophosphatase activity#GO:0016462;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG158885|UniProtKB=T1END5 T1END5 20198085 PTHR15644:SF2 OSTEOPETROSIS ASSOCIATED TRANSMEMBRANE PROTEIN 1 OSTEOPETROSIS-ASSOCIATED TRANSMEMBRANE PROTEIN 1 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG167061|UniProtKB=T1EYY8 T1EYY8 20201788 PTHR19972:SF10 CALBINDIN CALBINDIN-32 cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;intracellular monoatomic cation homeostasis#GO:0030003;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic ion homeostasis#GO:0006873;cellular homeostasis#GO:0019725;regulation of cytosolic calcium ion concentration#GO:0051480;intracellular chemical homeostasis#GO:0055082;chemical homeostasis#GO:0048878;intracellular calcium ion homeostasis#GO:0006874;monoatomic ion homeostasis#GO:0050801 cytoplasm#GO:0005737;synapse#GO:0045202;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;neuron projection#GO:0043005;cell junction#GO:0030054;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG177959|UniProtKB=T1FCI7 T1FCI7 20206536 PTHR10174:SF208 ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED CRAL-TRIO DOMAIN-CONTAINING PROTEIN DDB_G0278031 phosphatidylinositol bisphosphate binding#GO:1902936;lipid binding#GO:0008289;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981;binding#GO:0005488 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG67530|UniProtKB=T1FZ23 T1FZ23 20214071 PTHR24347:SF412 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE H1 HOMOLOG-RELATED non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CaMK#P00847;Ionotropic glutamate receptor pathway#P00037>CaMKII#P01023 HELRO|EnsemblGenome=HelroG90450|UniProtKB=T1G7R5 T1G7R5 20217112 PTHR39948:SF1 GEO11419P1 GEO11419P1 HELRO|EnsemblGenome=HelroG142702|UniProtKB=T1EJ69 T1EJ69 20196619 PTHR10231:SF43 NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER UDP-SUGAR TRANSPORTER PROTEIN SLC35A4-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 cytoplasm#GO:0005737;bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG162833|UniProtKB=T1ET86 T1ET86 20199786 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161444|UniProtKB=T1ERH2 T1ERH2 20199172 PTHR13378:SF1 REGULATOR COMPLEX PROTEIN LAMTOR3 RAGULATOR COMPLEX PROTEIN LAMTOR3 positive regulation of signal transduction#GO:0009967;regulation of signaling#GO:0023051;cellular response to nitrogen compound#GO:1901699;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;positive regulation of response to stimulus#GO:0048584;cellular response to oxygen-containing compound#GO:1901701;response to endogenous stimulus#GO:0009719;positive regulation of TOR signaling#GO:0032008;regulation of signal transduction#GO:0009966;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;response to organic substance#GO:0010033;regulation of cell communication#GO:0010646;cellular response to stimulus#GO:0051716;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;cellular response to organic substance#GO:0071310;response to organonitrogen compound#GO:0010243;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;cellular response to organonitrogen compound#GO:0071417;positive regulation of cell communication#GO:0010647;biological regulation#GO:0065007 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;vacuolar membrane#GO:0005774;vacuole#GO:0005773;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;guanyl-nucleotide exchange factor complex#GO:0032045 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG191543|UniProtKB=T1FT24 T1FT24 20211971 PTHR23090:SF9 NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE cellular aromatic compound metabolic process#GO:0006725;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;pyridine nucleotide metabolic process#GO:0019362;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;nucleotide biosynthetic process#GO:0009165;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;nicotinamide nucleotide metabolic process#GO:0046496;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG168899|UniProtKB=T1F141 T1F141 20202541 PTHR24033:SF193 EGF-LIKE DOMAIN-CONTAINING PROTEIN NETRIN-G1-RELATED Axon guidance mediated by netrin#P00009>Netrin#P00357;Axon guidance mediated by Slit/Robo#P00008>Netrin#P00344 HELRO|EnsemblGenome=HelroG194246|UniProtKB=T1FVU8 T1FVU8 20212944 PTHR43806:SF7 PEPTIDASE S8 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-1 PROTEASE hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG76005|UniProtKB=T1G2D9 T1G2D9 20215237 PTHR46473:SF26 GH08155P LRRNT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG62761|UniProtKB=T1FX47 T1FX47 20213395 PTHR14911:SF13 THUMP DOMAIN-CONTAINING TRNA (GUANINE(6)-N2)-METHYLTRANSFERASE THUMP3 tRNA methyltransferase activity#GO:0008175;catalytic activity, acting on RNA#GO:0140098;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;RNA methyltransferase activity#GO:0008173 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;macromolecule methylation#GO:0043414;tRNA methylation#GO:0030488;organic cyclic compound metabolic process#GO:1901360;methylation#GO:0032259;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;RNA methylation#GO:0001510;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 RNA metabolism protein#PC00031;RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG91231|UniProtKB=T1G814 T1G814 20217211 PTHR11225:SF4 NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN NUCLEAR PORE COMPLEX PROTEIN NUP93 structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;protein localization to nucleus#GO:0034504;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;RNA localization#GO:0006403;organic substance transport#GO:0071702;protein import into nucleus#GO:0006606;establishment of localization#GO:0051234;RNA transport#GO:0050658;protein localization to organelle#GO:0033365;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;poly(A)+ mRNA export from nucleus#GO:0016973;mRNA export from nucleus#GO:0006406;macromolecule biosynthetic process#GO:0009059;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;mRNA transport#GO:0051028;cellular process#GO:0009987;protein localization#GO:0008104;localization#GO:0051179;cellular macromolecule localization#GO:0070727;nuclear export#GO:0051168;nucleocytoplasmic transport#GO:0006913;nucleobase-containing compound transport#GO:0015931;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;import into nucleus#GO:0051170 envelope#GO:0031975;nuclear pore#GO:0005643;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG140298|UniProtKB=T1EJ04 T1EJ04 20196554 PTHR24058:SF112 DUAL SPECIFICITY PROTEIN KINASE DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 3 HOMOLOG-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;peptidyl-threonine phosphorylation#GO:0018107;nitrogen compound metabolic process#GO:0006807;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG180247|UniProtKB=T1FFM5 T1FFM5 20207624 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG69644|UniProtKB=T1FZX7 T1FZX7 20214375 PTHR46641:SF25 FMRFAMIDE RECEPTOR-RELATED CNMAMIDE RECEPTOR-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG184964|UniProtKB=T1FM77 T1FM77 20209926 PTHR13011:SF0 TFIIF-ALPHA GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1 basal RNA polymerase II transcription machinery binding#GO:0001099;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;basal transcription machinery binding#GO:0001098;transcription factor binding#GO:0008134;binding#GO:0005488 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;transcription initiation at RNA polymerase II promoter#GO:0006367;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nucleobase-containing compound biosynthetic process#GO:0034654;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;RNA polymerase II transcription regulator complex#GO:0090575;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase II, holoenzyme#GO:0016591;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;transcription regulator complex#GO:0005667;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;general transcription factor#PC00259 General transcription regulation#P00023>TFIIFalpha#P00663;Transcription regulation by bZIP transcription factor#P00055>TFIIFalpha#P01391 HELRO|EnsemblGenome=HelroG109453|UniProtKB=T1EET9 T1EET9 20195091 PTHR24023:SF1112 COLLAGEN ALPHA COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN-RELATED structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922 HELRO|EnsemblGenome=HelroG83982|UniProtKB=T1G5C5 T1G5C5 20216272 PTHR12241:SF161 TUBULIN POLYGLUTAMYLASE TUBULIN POLYGLUTAMYLASE TTLL6 cytoskeletal protein binding#GO:0008092;ligase activity#GO:0016874;protein binding#GO:0005515;tubulin binding#GO:0015631;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;microtubule cytoskeleton organization#GO:0000226;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;cellular component organization#GO:0016043;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;nitrogen compound metabolic process#GO:0006807;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;cilium#GO:0005929;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG107437|UniProtKB=T1EEA6 T1EEA6 20194908 PTHR23083:SF464 TETRATRICOPEPTIDE REPEAT PROTEIN, TPR TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A HELRO|EnsemblGenome=HelroG194659|UniProtKB=T1FWA4 T1FWA4 20213100 PTHR22767:SF3 N-TERMINAL ACETYLTRANSFERASE-RELATED N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;peptidyl-amino acid modification#GO:0018193;protein acylation#GO:0043543;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein acetylation#GO:0006473;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;acetyltransferase complex#GO:1902493;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 acetyltransferase#PC00038 HELRO|EnsemblGenome=HelroG64915|UniProtKB=T1FY12 T1FY12 20213710 PTHR22997:SF3 PIH1 DOMAIN-CONTAINING PROTEIN 1 PROTEIN KINTOUN cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG169264|UniProtKB=T1F1N6 T1F1N6 20202736 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193365|UniProtKB=T1FUX1 T1FUX1 20212617 PTHR25464:SF2 TRIPARTITE MOTIF-CONTAINING PROTEIN 2-LIKE PROTEIN RING-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183621|UniProtKB=T1FJY2 T1FJY2 20209131 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG191609|UniProtKB=T1FT45 T1FT45 20211992 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG173173|UniProtKB=T1F6I3 T1F6I3 20204432 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173260|UniProtKB=T1F6M2 T1F6M2 20204471 PTHR11961:SF12 CYTOCHROME C CYTOCHROME C Apoptosis signaling pathway#P00006>Cytochrome C#P00322;ATP synthesis#P02721>Cyt C#P02798 HELRO|EnsemblGenome=HelroG195101|UniProtKB=T1FWR1 T1FWR1 20213256 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG181531|UniProtKB=T1FH31 T1FH31 20208130 PTHR24107:SF2 YNEIN REGULATORY COMPLEX SUBUNIT 5 NLR FAMILY CARD DOMAIN CONTAINING 3 non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG161124|UniProtKB=T1ER42 T1ER42 20199042 PTHR14418:SF5 CONDENSIN COMPLEX SUBUNIT 3-RELATED CONDENSIN COMPLEX SUBUNIT 3 nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;nuclear division#GO:0000280;cell cycle process#GO:0022402;chromosome condensation#GO:0030261;cellular component organization#GO:0016043;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047;chromosome segregation#GO:0007059;mitotic chromosome condensation#GO:0007076;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;chromosome organization#GO:0051276;organelle organization#GO:0006996;cell cycle#GO:0007049;mitotic nuclear division#GO:0140014;organelle fission#GO:0048285;mitotic sister chromatid segregation#GO:0000070 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;chromosome#GO:0005694;condensed chromosome#GO:0000793;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG67144|UniProtKB=T1FYX4 T1FYX4 20214022 PTHR16058:SF4 DOUBLE ZINC RIBBON AND ANKYRIN REPEAT-CONTAINING PROTEIN 1 DOUBLE ZINC RIBBON AND ANKYRIN REPEAT-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG153367|UniProtKB=T1EL58 T1EL58 20197302 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188533|UniProtKB=T1FQ37 T1FQ37 20210934 PTHR13707:SF23 KETOACID-COENZYME A TRANSFERASE SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE transferase activity#GO:0016740;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity#GO:0003824 cellular metabolic process#GO:0044237;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG164276|UniProtKB=T1EV71 T1EV71 20200471 PTHR22763:SF162 RING ZINC FINGER PROTEIN TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG171404|UniProtKB=T1F484 T1F484 20203633 PTHR46458:SF1 BLR2807 PROTEIN GEO09476P1 transporter#PC00227 HELRO|EnsemblGenome=HelroG91084|UniProtKB=T1G7Z6 T1G7Z6 20217193 PTHR18847:SF0 20 KD NUCLEAR CAP BINDING PROTEIN NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;RNA cap binding#GO:0000339;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG145685|UniProtKB=T1EJM0 T1EJM0 20196770 PTHR24393:SF138 ZINC FINGER PROTEIN IP01201P-RELATED DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG191380|UniProtKB=T1FSY0 T1FSY0 20211927 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185746|UniProtKB=T1FN84 T1FN84 20210282 PTHR13234:SF8 GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 reductase#PC00198;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG185615|UniProtKB=T1FN15 T1FN15 20210214 PTHR10266:SF3 CYTOCHROME C1 CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL ATP synthesis#P02721>Cyt bc1#P02799;FAS signaling pathway#P00020>CytochromeC#P00620;Huntington disease#P00029>Cytochrome c#P00785 HELRO|EnsemblGenome=HelroG163488|UniProtKB=T1EU43 T1EU43 20200093 PTHR23210:SF26 ACTIVATING TRANSCRIPTION FACTOR 7 INTERACTING PROTEIN ACTIVATING TRANSCRIPTION FACTOR 7-INTERACTING PROTEIN 1 molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 regulation of chromosome organization#GO:0033044;positive regulation of organelle organization#GO:0010638;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular component biogenesis#GO:0044087;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;regulation of chromatin organization#GO:1902275;positive regulation of cellular component biogenesis#GO:0044089;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG101643|UniProtKB=T1ED62 T1ED62 20194514 PTHR43272:SF32 LONG-CHAIN-FATTY-ACID--COA LIGASE AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN long-chain fatty acid-CoA ligase activity#GO:0004467;ligase activity#GO:0016874;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG86403|UniProtKB=T1G6B7 T1G6B7 20216614 PTHR10760:SF2 TORSIN LD13476P-RELATED chaperone#PC00072 Parkinson disease#P00049>Torsin A#P01221 HELRO|EnsemblGenome=HelroG184653|UniProtKB=T1FLP3 T1FLP3 20209742 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG107583|UniProtKB=T1EEB5 T1EEB5 20194917 PTHR11502:SF6 40S RIBOSOMAL PROTEIN S6 SMALL RIBOSOMAL SUBUNIT PROTEIN ES6 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG176961|UniProtKB=T1FB25 T1FB25 20206024 PTHR22691:SF8 YEAST SPT2-RELATED PROTEIN SPT2 HOMOLOG nucleic acid binding#GO:0003676;protein binding#GO:0005515;histone binding#GO:0042393;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;nucleosome organization#GO:0034728;nucleosome assembly#GO:0006334;RNA metabolic process#GO:0016070;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;transcription by RNA polymerase I#GO:0006360;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;chromatin organization#GO:0006325;aromatic compound biosynthetic process#GO:0019438;chromatin remodeling#GO:0006338 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG174081|UniProtKB=T1F7K8 T1F7K8 20204807 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170281|UniProtKB=T1F2V6 T1F2V6 20203155 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG76588|UniProtKB=T1G2L8 T1G2L8 20215316 PTHR23115:SF36 TRANSLATION FACTOR G1 TO S PHASE TRANSITION 2 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;nucleic acid binding#GO:0003676;translation regulator activity#GO:0045182;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;translation regulator activity, nucleic acid binding#GO:0090079;translation factor activity, RNA binding#GO:0008135 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG109161|UniProtKB=T1EEQ7 T1EEQ7 20195059 PTHR11561:SF0 PHOSPHOENOLPYRUVATE CARBOXYKINASE PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP]-RELATED cation binding#GO:0043169;carboxy-lyase activity#GO:0016831;carbon-carbon lyase activity#GO:0016830;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;lyase activity#GO:0016829;ion binding#GO:0043167 dicarboxylic acid metabolic process#GO:0043648;alcohol biosynthetic process#GO:0046165;lipid catabolic process#GO:0016042;response to extracellular stimulus#GO:0009991;acylglycerol metabolic process#GO:0006639;lipid biosynthetic process#GO:0008610;neutral lipid metabolic process#GO:0006638;triglyceride biosynthetic process#GO:0019432;carboxylic acid catabolic process#GO:0046395;cellular lipid catabolic process#GO:0044242;organic substance metabolic process#GO:0071704;organic hydroxy compound metabolic process#GO:1901615;oxoacid metabolic process#GO:0043436;response to oxygen-containing compound#GO:1901700;cellular response to organic substance#GO:0071310;cellular metabolic process#GO:0044237;alcohol metabolic process#GO:0006066;intracellular chemical homeostasis#GO:0055082;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;hexose biosynthetic process#GO:0019319;organic acid catabolic process#GO:0016054;response to glucose#GO:0009749;small molecule catabolic process#GO:0044282;response to stress#GO:0006950;small molecule biosynthetic process#GO:0044283;carbohydrate homeostasis#GO:0033500;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329;lipid metabolic process#GO:0006629;monosaccharide metabolic process#GO:0005996;response to lipid#GO:0033993;organic hydroxy compound biosynthetic process#GO:1901617;biosynthetic process#GO:0009058;cellular homeostasis#GO:0019725;cellular response to oxygen-containing compound#GO:1901701;glycerolipid metabolic process#GO:0046486;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carbohydrate metabolic process#GO:0005975;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;response to organic substance#GO:0010033;carbohydrate biosynthetic process#GO:0016051;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;triglyceride metabolic process#GO:0006641;glycerolipid biosynthetic process#GO:0045017;glucose homeostasis#GO:0042593;homeostatic process#GO:0042592;cellular biosynthetic process#GO:0044249;response to nutrient levels#GO:0031667;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;chemical homeostasis#GO:0048878;glucose metabolic process#GO:0006006;fatty acid catabolic process#GO:0009062;response to external stimulus#GO:0009605;response to stimulus#GO:0050896;intracellular glucose homeostasis#GO:0001678;fatty acid metabolic process#GO:0006631;response to chemical#GO:0042221;response to starvation#GO:0042594;hexose metabolic process#GO:0019318;cellular lipid metabolic process#GO:0044255;carboxylic acid metabolic process#GO:0019752 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 kinase#PC00137 Pyruvate metabolism#P02772>Phosphoenolpyruvate Carboxykinase#P03135 HELRO|EnsemblGenome=HelroG185625|UniProtKB=T1FN21 T1FN21 20210220 PTHR11056:SF0 HOMOGENTISATE 1,2-DIOXYGENASE HOMOGENTISATE 1,2-DIOXYGENASE oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;dioxygenase activity#GO:0051213 cellular aromatic compound metabolic process#GO:0006725;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;amino acid catabolic process#GO:0009063;organic acid catabolic process#GO:0016054;aromatic compound catabolic process#GO:0019439;aromatic amino acid metabolic process#GO:0009072;organic cyclic compound metabolic process#GO:1901360;small molecule catabolic process#GO:0044282;nitrogen compound metabolic process#GO:0006807;organic cyclic compound catabolic process#GO:1901361;alpha-amino acid metabolic process#GO:1901605;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;aromatic amino acid family catabolic process#GO:0009074;amino acid metabolic process#GO:0006520;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG172151|UniProtKB=T1F526 T1F526 20203925 PTHR14017:SF1 LYSINE-SPECIFIC DEMETHYLASE LD02225P cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;chromatin DNA binding#GO:0031490;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;protein-containing complex binding#GO:0044877 regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG176332|UniProtKB=T1FAE4 T1FAE4 20205793 PTHR24104:SF54 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED E3 UBIQUITIN-PROTEIN LIGASE TRIM32-LIKE transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG176791|UniProtKB=T1FAX0 T1FAX0 20205969 PTHR15572:SF0 GLIOMA TUMOR SUPPRESSOR CANDIDATE REGION GENE 1 GLUTAMINE-RICH PROTEIN-RELATED positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;ATPase complex#GO:1904949;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;SWI/SNF complex#GO:0016514;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG178781|UniProtKB=T1FDQ5 T1FDQ5 20206954 PTHR43404:SF1 LIPOPOLYSACCHARIDE CHOLINEPHOSPHOTRANSFERASE LICD MNN4P transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG165757|UniProtKB=T1EX93 T1EX93 20201193 PTHR45797:SF1 RAD54-LIKE HELICASE ARIP4 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG81951|UniProtKB=T1G4K9 T1G4K9 20216007 PTHR11764:SF20 TERPENE CYCLASE/MUTASE FAMILY MEMBER LANOSTEROL SYNTHASE cyclase#PC00079;lyase#PC00144 Cholesterol biosynthesis#P00014>Anosterol synthase#P00497 HELRO|EnsemblGenome=HelroG171733|UniProtKB=T1F4L3 T1F4L3 20203762 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175273|UniProtKB=T1F931 T1F931 20205330 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG98248|UniProtKB=T1G9L2 T1G9L2 20217758 PTHR11202:SF22 SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER PROTEIN ENABLED scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG176473|UniProtKB=T1FAJ5 T1FAJ5 20205844 PTHR34009:SF2 PROTEIN STAR PROTEIN STAR localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;endosomal transport#GO:0016197;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987 bounding membrane of organelle#GO:0098588;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;late endosome membrane#GO:0031902;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;endosome membrane#GO:0010008;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle membrane#GO:0030659;endoplasmic reticulum#GO:0005783;late endosome#GO:0005770;plasma membrane#GO:0005886;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG110752|UniProtKB=T1EF51 T1EF51 20195203 PTHR46756:SF18 TRANSGELIN GAS2-LIKE PROTEIN PICKLED EGGS cytoskeletal protein binding#GO:0008092;molecular adaptor activity#GO:0060090;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;actin filament binding#GO:0051015;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 supramolecular complex#GO:0099080;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;supramolecular fiber#GO:0099512;supramolecular polymer#GO:0099081;actin filament#GO:0005884;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG80463|UniProtKB=T1G412 T1G412 20215810 PTHR11406:SF0 PHOSPHOGLYCERATE KINASE PHOSPHOGLYCERATE KINASE carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;transferase activity#GO:0016740;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;transferase activity, transferring phosphorus-containing groups#GO:0016772;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168;kinase activity#GO:0016301;ATP binding#GO:0005524 ribonucleoside triphosphate metabolic process#GO:0009199;nucleoside triphosphate metabolic process#GO:0009141;heterocycle catabolic process#GO:0046700;ribonucleotide catabolic process#GO:0009261;pyridine nucleotide metabolic process#GO:0019362;nucleobase-containing compound metabolic process#GO:0006139;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;purine ribonucleotide catabolic process#GO:0009154;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;oxoacid metabolic process#GO:0043436;nucleoside phosphate catabolic process#GO:1901292;carbohydrate derivative catabolic process#GO:1901136;purine ribonucleoside triphosphate metabolic process#GO:0009205;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;nucleotide catabolic process#GO:0009166;cellular nitrogen compound metabolic process#GO:0034641;nicotinamide nucleotide metabolic process#GO:0046496;nucleoside diphosphate catabolic process#GO:0009134;organic acid metabolic process#GO:0006082;ribonucleotide metabolic process#GO:0009259;monocarboxylic acid metabolic process#GO:0032787;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;organophosphate catabolic process#GO:0046434;hexose biosynthetic process#GO:0019319;glycolytic process#GO:0006096;organophosphate metabolic process#GO:0019637;small molecule biosynthetic process#GO:0044283;nucleobase-containing compound catabolic process#GO:0034655;nucleotide metabolic process#GO:0009117;small molecule metabolic process#GO:0044281;cellular aromatic compound metabolic process#GO:0006725;monosaccharide metabolic process#GO:0005996;carbohydrate derivative metabolic process#GO:1901135;organonitrogen compound catabolic process#GO:1901565;biosynthetic process#GO:0009058;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;purine-containing compound catabolic process#GO:0072523;cellular nitrogen compound catabolic process#GO:0044270;purine nucleotide catabolic process#GO:0006195;organic cyclic compound metabolic process#GO:1901360;carbohydrate catabolic process#GO:0016052;catabolic process#GO:0009056;nucleoside diphosphate metabolic process#GO:0009132;organic substance catabolic process#GO:1901575;carbohydrate metabolic process#GO:0005975;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;carbohydrate biosynthetic process#GO:0016051;heterocycle metabolic process#GO:0046483;organonitrogen compound metabolic process#GO:1901564;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;glucose metabolic process#GO:0006006;aromatic compound catabolic process#GO:0019439;organic cyclic compound catabolic process#GO:1901361;purine nucleoside triphosphate metabolic process#GO:0009144;hexose metabolic process#GO:0019318;carboxylic acid metabolic process#GO:0019752;nucleobase-containing small molecule metabolic process#GO:0055086 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 carbohydrate kinase#PC00065 Glycolysis#P00024>Phosphoglycerate kinase#P00671 HELRO|EnsemblGenome=HelroG170732|UniProtKB=T1F3D2 T1F3D2 20203331 PTHR15911:SF6 WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL basal RNA polymerase II transcription machinery binding#GO:0001099;RNA polymerase binding#GO:0070063;binding#GO:0005488;chromatin binding#GO:0003682;RNA polymerase core enzyme binding#GO:0043175;RNA polymerase II complex binding#GO:0000993;enzyme binding#GO:0019899;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;basal transcription machinery binding#GO:0001098 regulation of cell communication#GO:0010646;positive regulation of TORC1 signaling#GO:1904263;regulation of TORC1 signaling#GO:1903432;regulation of catabolic process#GO:0009894;positive regulation of signal transduction#GO:0009967;regulation of autophagy#GO:0010506;regulation of signaling#GO:0023051;regulation of cellular catabolic process#GO:0031329;regulation of intracellular signal transduction#GO:1902531;regulation of TOR signaling#GO:0032006;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;positive regulation of response to stimulus#GO:0048584;regulation of cellular process#GO:0050794;positive regulation of TOR signaling#GO:0032008;regulation of signal transduction#GO:0009966;positive regulation of cell communication#GO:0010647;biological regulation#GO:0065007;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG183965|UniProtKB=T1FKD2 T1FKD2 20209281 PTHR10656:SF42 CELL FATE DETERMINING PROTEIN MAB21-RELATED CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED transferase#PC00220;nucleotidyltransferase#PC00174;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG192481|UniProtKB=T1FU03 T1FU03 20212299 PTHR10334:SF498 CYSTEINE-RICH SECRETORY PROTEIN-RELATED MIP16674P defense/immunity protein#PC00090 PI3 kinase pathway#P00048>scl-1#G01545 HELRO|EnsemblGenome=HelroG187622|UniProtKB=T1FPB4 T1FPB4 20210661 PTHR10663:SF333 GUANYL-NUCLEOTIDE EXCHANGE FACTOR PROTEIN MON2 HOMOLOG guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG184938|UniProtKB=T1FM67 T1FM67 20209916 PTHR10256:SF0 SELENIDE, WATER DIKINASE INACTIVE SELENIDE, WATER DIKINASE-LIKE PROTEIN-RELATED transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;proteinogenic amino acid biosynthetic process#GO:0170038;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;alpha-amino acid biosynthetic process#GO:1901607;nitrogen compound metabolic process#GO:0006807;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;small molecule biosynthetic process#GO:0044283;L-amino acid biosynthetic process#GO:0170034;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG116695|UniProtKB=T1EGH0 T1EGH0 20195672 PTHR45623:SF11 CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED KISMET, ISOFORM C ATP-dependent activity, acting on DNA#GO:0008094;nucleic acid binding#GO:0003676;binding#GO:0005488;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887;histone binding#GO:0042393;pyrophosphatase activity#GO:0016462;ATP-dependent activity#GO:0140657;chromatin binding#GO:0003682;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity, acting on DNA#GO:0140097;protein-containing complex binding#GO:0044877 cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;protein-DNA complex organization#GO:0071824;cellular component organization#GO:0016043;cellular process#GO:0009987;chromatin remodeling#GO:0006338;protein-containing complex organization#GO:0043933 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG194764|UniProtKB=T1FWE0 T1FWE0 20213135 PTHR12307:SF53 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT phosphatase binding#GO:0019902;enzyme binding#GO:0019899;protein binding#GO:0005515;carbohydrate binding#GO:0030246;protein phosphatase binding#GO:0019903;binding#GO:0005488 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein serine/threonine phosphatase complex#GO:0008287;cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG165875|UniProtKB=T1EXE0 T1EXE0 20201240 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG72578|UniProtKB=T1G121 T1G121 20214769 PTHR20961:SF148 GLYCOSYLTRANSFERASE EGF DOMAIN-SPECIFIC O-LINKED N-ACETYLGLUCOSAMINE TRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG73994|UniProtKB=T1G1K9 T1G1K9 20214957 PTHR11239:SF14 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;RNA polymerase activity#GO:0097747;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;RNA polymerase I activity#GO:0001054 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;transcription by RNA polymerase I#GO:0006360;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;RNA polymerase I complex#GO:0005736;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG166503|UniProtKB=T1EY67 T1EY67 20201517 PTHR12991:SF10 NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4 GATOR COMPLEX PROTEIN NPRL2 nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of TORC1 signaling#GO:1903432;negative regulation of response to stimulus#GO:0048585;regulation of catabolic process#GO:0009894;negative regulation of intracellular signal transduction#GO:1902532;regulation of autophagy#GO:0010506;positive regulation of cellular metabolic process#GO:0031325;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;positive regulation of cellular catabolic process#GO:0031331;regulation of cellular catabolic process#GO:0031329;regulation of intracellular signal transduction#GO:1902531;negative regulation of TOR signaling#GO:0032007;regulation of TOR signaling#GO:0032006;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of catabolic process#GO:0009896;negative regulation of signal transduction#GO:0009968;positive regulation of autophagy#GO:0010508;negative regulation of TORC1 signaling#GO:1904262;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;negative regulation of cell communication#GO:0010648;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;Seh1-associated complex#GO:0035859;intracellular membrane-bounded organelle#GO:0043231;vacuolar membrane#GO:0005774;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG161839|UniProtKB=T1ERY7 T1ERY7 20199337 PTHR22055:SF0 28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN 28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG171677|UniProtKB=T1F4J4 T1F4J4 20203743 PTHR43939:SF125 COILED-COIL DOMAIN-CONTAINING PROTEIN 158 NUP-1 PROTEIN HELRO|EnsemblGenome=HelroG155605|UniProtKB=T1ELJ5 T1ELJ5 20197445 PTHR11028:SF0 VACUOLAR ATP SYNTHASE SUBUNIT AC39 V-TYPE PROTON ATPASE SUBUNIT D 1 regulation of intracellular pH#GO:0051453;cellular localization#GO:0051641;vacuolar transport#GO:0007034;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;regulation of pH#GO:0006885;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;intracellular monoatomic cation homeostasis#GO:0030003;biological regulation#GO:0065007;intracellular pH reduction#GO:0051452;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;intracellular monoatomic ion homeostasis#GO:0006873;regulation of cellular pH#GO:0030641;vacuolar acidification#GO:0007035 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;vacuolar membrane#GO:0005774;ATPase complex#GO:1904949;vacuole#GO:0005773;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;proton-transporting two-sector ATPase complex#GO:0016469;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG102862|UniProtKB=T1EDC5 T1EDC5 20194577 PTHR14190:SF7 SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG syntaxin binding#GO:0019905;protein binding#GO:0005515;binding#GO:0005488;SNARE binding#GO:0000149 endosomal transport#GO:0016197;localization within membrane#GO:0051668;cellular localization#GO:0051641;vesicle-mediated transport to the plasma membrane#GO:0098876;vacuolar transport#GO:0007034;post-Golgi vesicle-mediated transport#GO:0006892;transport#GO:0006810;vesicle-mediated transport#GO:0016192;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147;localization#GO:0051179;endocytic recycling#GO:0032456;establishment of localization#GO:0051234;Golgi to vacuole transport#GO:0006896;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;vesicle tethering complex#GO:0099023;Golgi apparatus#GO:0005794;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG112911|UniProtKB=T1EFN3 T1EFN3 20195385 PTHR11409:SF39 ADENOSINE DEAMINASE ADENOSINE DEAMINASE 2 hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;adenosine deaminase activity#GO:0004000;deaminase activity#GO:0019239;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;nucleoside metabolic process#GO:0009116;glycosyl compound catabolic process#GO:1901658;carbohydrate derivative metabolic process#GO:1901135;heterocycle catabolic process#GO:0046700;organonitrogen compound catabolic process#GO:1901565;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase metabolic process#GO:0009112;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;purine-containing compound catabolic process#GO:0072523;organic cyclic compound metabolic process#GO:1901360;purine nucleoside metabolic process#GO:0042278;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;purine-containing compound metabolic process#GO:0072521;catabolic process#GO:0009056;nucleoside catabolic process#GO:0009164;organic substance catabolic process#GO:1901575;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;carbohydrate derivative catabolic process#GO:1901136;purine nucleobase metabolic process#GO:0006144;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;purine nucleoside catabolic process#GO:0006152;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;aromatic compound catabolic process#GO:0019439;nucleobase-containing compound biosynthetic process#GO:0034654;small molecule catabolic process#GO:0044282;nucleobase-containing small molecule catabolic process#GO:0034656;adenosine metabolic process#GO:0046085;organic cyclic compound catabolic process#GO:1901361;aromatic compound biosynthetic process#GO:0019438;small molecule biosynthetic process#GO:0044283;nucleobase-containing compound catabolic process#GO:0034655;glycosyl compound metabolic process#GO:1901657;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 deaminase#PC00088;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG174608|UniProtKB=T1F8A8 T1F8A8 20205057 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG160693|UniProtKB=T1EQL9 T1EQL9 20198869 PTHR10891:SF918 EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN CALCIUM-BINDING PROTEIN 2 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG166293|UniProtKB=T1EXZ7 T1EXZ7 20201447 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158698|UniProtKB=T1EN50 T1EN50 20198000 PTHR24270:SF62 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 apolipoprotein#PC00052 HELRO|EnsemblGenome=HelroG167639|UniProtKB=T1EZL4 T1EZL4 20202014 PTHR10684:SF4 NUCLEAR RECEPTOR COACTIVATOR TAIMAN, ISOFORM G molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;nuclear receptor coactivator activity#GO:0030374;nuclear receptor binding#GO:0016922;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;transcription coactivator activity#GO:0003713;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515;transcription factor binding#GO:0008134;DNA-binding transcription factor binding#GO:0140297 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;cellular response to endogenous stimulus#GO:0071495;cellular response to chemical stimulus#GO:0070887;cellular response to organic substance#GO:0071310;regulation of DNA-templated transcription#GO:0006355;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;response to hormone#GO:0009725;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;response to chemical#GO:0042221;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG188505|UniProtKB=T1FQ24 T1FQ24 20210921 PTHR11955:SF135 FATTY ACID BINDING PROTEIN FATTY ACID BINDING PROTEIN, ISOFORM C fatty acid binding#GO:0005504;small molecule binding#GO:0036094;binding#GO:0005488;carboxylic acid binding#GO:0031406;lipid binding#GO:0008289;ion binding#GO:0043167;organic acid binding#GO:0043177;anion binding#GO:0043168 localization#GO:0051179;monocarboxylic acid transport#GO:0015718;organic substance transport#GO:0071702;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;organic anion transport#GO:0015711;fatty acid transport#GO:0015908;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;lipid localization#GO:0010876;lipid transport#GO:0006869 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG104797|UniProtKB=T1EDN7 T1EDN7 20194689 PTHR47979:SF33 DRAB11-RELATED DRAB11 GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;anion binding#GO:0043168;ion binding#GO:0043167 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;transport#GO:0006810 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG186407|UniProtKB=T1FNZ3 T1FNZ3 20210540 PTHR24055:SF158 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE P38A-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 TGF-beta signaling pathway#P00052>P38#P01275;Interferon-gamma signaling pathway#P00035>Serine kinase#P00955;EGF receptor signaling pathway#P00018>p38#P00562;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;p53 pathway feedback loops 2#P04398>p38 MAPK#P04648;Ras Pathway#P04393>p38#P04558;Parkinson disease#P00049>p38 MAPK#P01212;Oxidative stress response#P00046>p38#P01135;Parkinson disease#P00049>SAPK#P01219;FGF signaling pathway#P00021>p38#P00644 HELRO|EnsemblGenome=HelroG182592|UniProtKB=T1FIF5 T1FIF5 20208604 PTHR18945:SF865 NEUROTRANSMITTER GATED ION CHANNEL NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA7, ISOFORM E ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG82849|UniProtKB=T1G4X4 T1G4X4 20216122 PTHR42904:SF6 NUDIX HYDROLASE, NUDC SUBFAMILY NAD-CAPPED RNA HYDROLASE NUDT12 pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;heterocycle catabolic process#GO:0046700;organonitrogen compound catabolic process#GO:1901565;pyridine nucleotide metabolic process#GO:0019362;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;cellular nitrogen compound catabolic process#GO:0044270;phosphate-containing compound metabolic process#GO:0006796;purine-containing compound catabolic process#GO:0072523;organic cyclic compound metabolic process#GO:1901360;purine nucleotide catabolic process#GO:0006195;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;NADP metabolic process#GO:0006739;purine nucleotide metabolic process#GO:0006163;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;nucleoside phosphate catabolic process#GO:1901292;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;nucleotide catabolic process#GO:0009166;nicotinamide nucleotide metabolic process#GO:0046496;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organophosphate catabolic process#GO:0046434;primary metabolic process#GO:0044238;aromatic compound catabolic process#GO:0019439;organic cyclic compound catabolic process#GO:1901361;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;nucleotide metabolic process#GO:0009117;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG163760|UniProtKB=T1EUF6 T1EUF6 20200206 PTHR46543:SF1 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;modification-dependent macromolecule catabolic process#GO:0043632;regulation of biological process#GO:0050789;ncRNA metabolic process#GO:0034660;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;mRNA catabolic process#GO:0006402;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;negative regulation of cellular process#GO:0048523;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;snRNA metabolic process#GO:0016073;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;nuclear-transcribed mRNA catabolic process#GO:0000956;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;rRNA metabolic process#GO:0016072;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;polyadenylation-dependent ncRNA catabolic process#GO:0043634;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG107832|UniProtKB=T1EED1 T1EED1 20194933 PTHR19134:SF553 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE 10D-RELATED hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195;protein modifying enzyme#PC00260 Axon guidance mediated by Slit/Robo#P00008>Ptp10D#P00343 HELRO|EnsemblGenome=HelroG184893|UniProtKB=T1FM49 T1FM49 20209898 PTHR12736:SF21 LANC-LIKE PROTEIN LANC-LIKE PROTEIN 2 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG170040|UniProtKB=T1F2K4 T1F2K4 20203053 PTHR47611:SF3 HAT DIMERISATION DOMAIN, C-TERMINAL HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG187989|UniProtKB=T1FPI9 T1FPI9 20210736 PTHR22960:SF0 MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1 lyase activity#GO:0016829;carbon-carbon lyase activity#GO:0016830;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824 heterocycle metabolic process#GO:0046483;macromolecule metabolic process#GO:0043170;organophosphate biosynthetic process#GO:0090407;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organophosphate metabolic process#GO:0019637;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG85712|UniProtKB=T1G621 T1G621 20216518 PTHR11909:SF428 CASEIN KINASE-RELATED CASEIN KINASE I ISOFORM EPSILON transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of protein metabolic process#GO:0051246;regulation of catabolic process#GO:0009894;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of signal transduction#GO:0009967;regulation of proteolysis involved in protein catabolic process#GO:1903050;positive regulation of proteolysis#GO:0045862;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;regulation of signal transduction#GO:0009966;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;positive regulation of proteolysis involved in protein catabolic process#GO:1903052;macromolecule metabolic process#GO:0043170;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cellular metabolic process#GO:0044237;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;cell communication#GO:0007154;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;positive regulation of canonical Wnt signaling pathway#GO:0090263;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of catabolic process#GO:0009896;positive regulation of protein catabolic process#GO:0045732;import into cell#GO:0098657;regulation of metabolic process#GO:0019222;positive regulation of nitrogen compound metabolic process#GO:0051173;signal transduction#GO:0007165;macromolecule modification#GO:0043412;regulation of signaling#GO:0023051;transport#GO:0006810;positive regulation of proteasomal protein catabolic process#GO:1901800;protein modification process#GO:0036211;regulation of protein catabolic process#GO:0042176;peptidyl-amino acid modification#GO:0018193;positive regulation of Wnt signaling pathway#GO:0030177;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;positive regulation of response to stimulus#GO:0048584;positive regulation of metabolic process#GO:0009893;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;signaling#GO:0023052;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;metabolic process#GO:0008152;regulation of cell communication#GO:0010646;regulation of proteolysis#GO:0030162;cellular response to stimulus#GO:0051716;organonitrogen compound metabolic process#GO:1901564;protein phosphorylation#GO:0006468;cellular process#GO:0009987;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of proteasomal protein catabolic process#GO:0061136;regulation of primary metabolic process#GO:0080090;localization#GO:0051179;response to stimulus#GO:0050896;positive regulation of protein metabolic process#GO:0051247;regulation of macromolecule metabolic process#GO:0060255;regulation of Wnt signaling pathway#GO:0030111;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;CCKR signaling map#P06959>CK1delta/epsilon#P07089;Hedgehog signaling pathway#P00025>Casein kinase I#P00681;Circadian clock system#P00015>Casein kinase I#P00502;Parkinson disease#P00049>Casein kinase I#P01242 HELRO|EnsemblGenome=HelroG73100|UniProtKB=T1G1A0 T1G1A0 20214848 PTHR23516:SF23 SAM (S-ADENOSYL METHIONINE) TRANSPORTER MOLYBDATE-ANION TRANSPORTER cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG85694|UniProtKB=T1G618 T1G618 20216515 PTHR24044:SF504 NOTCH LIGAND FAMILY MEMBER EGF-LIKE DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 regulation of cell communication#GO:0010646;signal transduction#GO:0007165;negative regulation of biological process#GO:0048519;cellular response to stimulus#GO:0051716;negative regulation of response to stimulus#GO:0048585;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;cell communication#GO:0007154;cellular process#GO:0009987;negative regulation of Notch signaling pathway#GO:0045746;regulation of Notch signaling pathway#GO:0008593;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of cell communication#GO:0010648;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;Notch signaling pathway#GO:0007219 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG112284|UniProtKB=T1EFI3 T1EFI3 20195335 PTHR24345:SF0 SERINE/THREONINE-PROTEIN KINASE PLK CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191220|UniProtKB=T1FSR3 T1FSR3 20211860 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG181443|UniProtKB=T1FH04 T1FH04 20208103 PTHR10117:SF54 TRANSIENT RECEPTOR POTENTIAL CHANNEL TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;small molecule binding#GO:0036094;binding#GO:0005488;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;anion binding#GO:0043168;ion binding#GO:0043167;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;alcohol binding#GO:0043178 inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;regulation of cytosolic calcium ion concentration#GO:0051480;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;calcium ion transport#GO:0006816;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 Alzheimer disease-presenilin pathway#P00004>Capacitative calcium channels#P00124 HELRO|EnsemblGenome=HelroG105332|UniProtKB=T1EDT8 T1EDT8 20194740 PTHR24006:SF664 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191598|UniProtKB=T1FT42 T1FT42 20211989 PTHR11037:SF21 TRANSCRIPTION FACTOR CP2 GEMINI, ISOFORM C DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG159994|UniProtKB=T1EPM9 T1EPM9 20198529 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG76894|UniProtKB=T1G2Q7 T1G2Q7 20215355 PTHR10537:SF3 DNA PRIMASE LARGE SUBUNIT DNA PRIMASE LARGE SUBUNIT cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated DNA replication#GO:0006261;aromatic compound biosynthetic process#GO:0019438;DNA replication#GO:0006260;DNA replication initiation#GO:0006270;DNA metabolic process#GO:0006259;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 DNA metabolism protein#PC00009;primase#PC00189 DNA replication#P00017>Primase#P00528 HELRO|EnsemblGenome=HelroG91314|UniProtKB=T1G824 T1G824 20217221 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG62592|UniProtKB=T1FX26 T1FX26 20213374 PTHR10357:SF179 ALPHA-AMYLASE FAMILY MEMBER NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 carbohydrate catabolic process#GO:0016052;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carbohydrate metabolic process#GO:0005975;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238;metabolic process#GO:0008152 amylase#PC00048;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG164816|UniProtKB=T1EVU6 T1EVU6 20200696 PTHR24416:SF604 TYROSINE-PROTEIN KINASE RECEPTOR RECEPTOR PROTEIN-TYROSINE KINASE signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;regulation of cell differentiation#GO:0045595;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;regulation of neuron differentiation#GO:0045664;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG122144|UniProtKB=T1EGU2 T1EGU2 20195792 PTHR24418:SF384 TYROSINE-PROTEIN KINASE ACTIVATED CDC42 KINASE 1 protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG168922|UniProtKB=T1F149 T1F149 20202549 PTHR21522:SF32 PROTON CHANNEL OTOP OTOPETRIN-2 monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078;proton channel activity#GO:0015252;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;proton transmembrane transport#GO:1902600;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG130121|UniProtKB=T1EHT1 T1EHT1 20196131 PTHR11537:SF113 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;delayed rectifier potassium channel activity#GO:0005251;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG176070|UniProtKB=T1FA38 T1FA38 20205687 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173902|UniProtKB=T1F7C4 T1F7C4 20204723 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164912|UniProtKB=T1EVY8 T1EVY8 20200738 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG177334|UniProtKB=T1FBI7 T1FBI7 20206186 PTHR10985:SF77 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED GH26014P sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of multicellular organismal process#GO:0051239;regulation of cell development#GO:0060284;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regionalization#GO:0003002;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of RNA biosynthetic process#GO:2001141;regulation of multicellular organismal development#GO:2000026;regulation of cell differentiation#GO:0045595;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of neurogenesis#GO:0050767;regulation of macromolecule metabolic process#GO:0060255;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;regulation of nervous system development#GO:0051960;biological regulation#GO:0065007;anterior/posterior pattern specification#GO:0009952;multicellular organismal process#GO:0032501;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;pattern specification process#GO:0007389;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG190986|UniProtKB=T1FSH1 T1FSH1 20211768 PTHR16195:SF16 ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 14 HELRO|EnsemblGenome=HelroG169759|UniProtKB=T1F2A9 T1F2A9 20202959 PTHR46600:SF1 THAP DOMAIN-CONTAINING THAP DOMAIN-CONTAINING PROTEIN 1 zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG171209|UniProtKB=T1F3Y1 T1F3Y1 20203530 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG163438|UniProtKB=T1EU18 T1EU18 20200068 PTHR46077:SF5 E3 UBIQUITIN-PROTEIN LIGASE TOPORS RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein monoubiquitination#GO:0006513;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG150681|UniProtKB=T1EKG8 T1EKG8 20197068 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG177915|UniProtKB=T1FCG6 T1FCG6 20206515 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG85485|UniProtKB=T1G5X8 T1G5X8 20216475 PTHR12064:SF94 METAL TRANSPORTER CNNM UNEXTENDED PROTEIN ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG183649|UniProtKB=T1FJZ7 T1FJZ7 20209146 PTHR31802:SF50 32 KDA HEAT SHOCK PROTEIN-RELATED DEATH DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG72335|UniProtKB=T1G0Y5 T1G0Y5 20214733 PTHR42985:SF40 SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER LD47995P-RELATED symporter activity#GO:0015293;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;monoatomic cation transport#GO:0006812;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG106302|UniProtKB=T1EE16 T1EE16 20194818 PTHR19842:SF0 G BETA-LIKE PROTEIN GBL TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8 signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;regulation of actin filament-based process#GO:0032970;intracellular signal transduction#GO:0035556;signaling#GO:0023052;TOR signaling#GO:0031929 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG158780|UniProtKB=T1EN91 T1EN91 20198041 PTHR21255:SF23 T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN DYNEIN LIGHT CHAIN protein binding#GO:0005515;binding#GO:0005488 microtubule-based movement#GO:0007018;cellular process#GO:0009987;microtubule-based process#GO:0007017 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;microtubule cytoskeleton#GO:0015630;dynein complex#GO:0030286;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic dynein complex#GO:0005868;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG114375|UniProtKB=T1EG11 T1EG11 20195513 PTHR11085:SF10 NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED nucleotide binding#GO:0000166;histone modifying activity#GO:0140993;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;deacetylase activity#GO:0019213;histone deacetylase activity#GO:0004407;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168;catalytic activity, acting on a protein#GO:0140096 HELRO|EnsemblGenome=HelroG155472|UniProtKB=T1ELI5 T1ELI5 20197435 PTHR16537:SF1 SJOEGREN SYNDROME/SCLERODERMA AUTOANTIGEN 1 PROTEIN ZNRD2 HELRO|EnsemblGenome=HelroG169093|UniProtKB=T1F1D8 T1F1D8 20202638 PTHR11799:SF12 PARAOXONASE PARAOXONASE-RELATED metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG84791|UniProtKB=T1G5N7 T1G5N7 20216384 PTHR11929:SF194 ALPHA- 1,3 -FUCOSYLTRANSFERASE ALPHA-(1,3)-FUCOSYLTRANSFERASE 10 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG88429|UniProtKB=T1G724 T1G724 20216871 PTHR46505:SF1 OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1 OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG160929|UniProtKB=T1EQV5 T1EQV5 20198955 PTHR43250:SF2 EXODEOXYRIBONUCLEASE III EXODEOXYRIBONUCLEASE III HELRO|EnsemblGenome=HelroG177663|UniProtKB=T1FC12 T1FC12 20206361 PTHR45930:SF4 G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN ADHESION G PROTEIN-COUPLED RECEPTOR A3 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG165447|UniProtKB=T1EWT4 T1EWT4 20201034 PTHR19303:SF71 TRANSPOSON ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG105279|UniProtKB=T1EDS8 T1EDS8 20194730 PTHR44111:SF1 ELONGATOR COMPLEX PROTEIN 2 ELONGATOR COMPLEX PROTEIN 2 HELRO|EnsemblGenome=HelroG162572|UniProtKB=T1ESU7 T1ESU7 20199647 PTHR31815:SF1 AGAP005329-PA TRANSMEMBRANE PROTEIN 200C HELRO|EnsemblGenome=HelroG184670|UniProtKB=T1FLQ7 T1FLQ7 20209756 PTHR46169:SF29 DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG67592|UniProtKB=T1FZ27 T1FZ27 20214075 PTHR13129:SF4 VPRBP PROTEIN-RELATED DDB1- AND CUL4-ASSOCIATED FACTOR 1 protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;Cul4-RING E3 ubiquitin ligase complex#GO:0080008 HELRO|EnsemblGenome=HelroG163446|UniProtKB=T1EU22 T1EU22 20200072 PTHR21694:SF18 COILED-COIL DOMAIN-CONTAINING PROTEIN 63 COILED-COIL DOMAIN-CONTAINING PROTEIN 63 HELRO|EnsemblGenome=HelroG191654|UniProtKB=T1FT64 T1FT64 20212011 PTHR23216:SF1 NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1 NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1 HELRO|EnsemblGenome=HelroG86038|UniProtKB=T1G663 T1G663 20216560 PTHR11210:SF60 RING BOX RING-BOX PROTEIN 2 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;cullin family protein binding#GO:0097602;protein binding#GO:0005515;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG165939|UniProtKB=T1EXH4 T1EXH4 20201274 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG191235|UniProtKB=T1FSR9 T1FSR9 20211866 PTHR45740:SF2 POLY [ADP-RIBOSE] POLYMERASE POLY [ADP-RIBOSE] POLYMERASE transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;pentosyltransferase activity#GO:0016763 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG156021|UniProtKB=T1ELQ7 T1ELQ7 20197507 PTHR22069:SF0 MITOCHONDRIAL RIBOSOMAL PROTEIN S18 RADIAL SPOKE HEAD PROTEIN 9 HOMOLOG cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;microtubule cytoskeleton organization#GO:0000226;microtubule-based movement#GO:0007018;cilium or flagellum-dependent cell motility#GO:0001539;cell motility#GO:0048870;cellular component organization#GO:0016043;axoneme assembly#GO:0035082;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;cilium movement involved in cell motility#GO:0060294;cilium movement#GO:0003341;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cilium-dependent cell motility#GO:0060285;microtubule-based process#GO:0007017;organelle organization#GO:0006996;microtubule bundle formation#GO:0001578;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection assembly#GO:0120031;motile cilium assembly#GO:0044458 axoneme#GO:0005930;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;plasma membrane bounded cell projection cytoplasm#GO:0032838;membrane-bounded organelle#GO:0043227;ciliary plasm#GO:0097014;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG72857|UniProtKB=T1G162 T1G162 20214810 PTHR25462:SF305 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG94522|UniProtKB=T1G917 T1G917 20217564 PTHR22748:SF4 AP ENDONUCLEASE DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2 hydrolase activity, acting on ester bonds#GO:0016788;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;3'-5'-DNA exonuclease activity#GO:0008296;nuclease activity#GO:0004518;DNA exonuclease activity#GO:0004529;catalytic activity#GO:0003824;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097;phosphoric diester hydrolase activity#GO:0008081;exonuclease activity#GO:0004527;3'-5' exonuclease activity#GO:0008408;phosphoric ester hydrolase activity#GO:0042578 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;base-excision repair#GO:0006284;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG82208|UniProtKB=T1G4P2 T1G4P2 20216040 PTHR48041:SF116 ABC TRANSPORTER G FAMILY MEMBER 28 PROTEIN BROWN transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG156718|UniProtKB=T1EM02 T1EM02 20197602 PTHR31078:SF1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 300 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 300 structural protein#PC00211 HELRO|EnsemblGenome=HelroG186092|UniProtKB=T1FNN4 T1FNN4 20210431 PTHR11959:SF1 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;dioxygenase activity#GO:0051213 cellular aromatic compound metabolic process#GO:0006725;oxoacid metabolic process#GO:0043436;tyrosine metabolic process#GO:0006570;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;aromatic compound catabolic process#GO:0019439;aromatic amino acid metabolic process#GO:0009072;organic cyclic compound metabolic process#GO:1901360;small molecule catabolic process#GO:0044282;nitrogen compound metabolic process#GO:0006807;alpha-amino acid metabolic process#GO:1901605;organic cyclic compound catabolic process#GO:1901361;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;carboxylic acid metabolic process#GO:0019752;aromatic amino acid family catabolic process#GO:0009074;amino acid metabolic process#GO:0006520;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG68712|UniProtKB=T1FZI7 T1FZI7 20214235 PTHR13417:SF2 E3 UBIQUITIN-PROTEIN LIGASE RNF146 E3 UBIQUITIN-PROTEIN LIGASE RNF146 carbohydrate derivative binding#GO:0097367;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG116079|UniProtKB=T1EGC8 T1EGC8 20195630 PTHR13832:SF699 PROTEIN PHOSPHATASE 2C INTEGRIN-LINKED KINASE-ASSOCIATED SERINE_THREONINE PHOSPHATASE 2C macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;dephosphorylation#GO:0016311;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG90115|UniProtKB=T1G7L2 T1G7L2 20217059 PTHR17605:SF0 RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN RIBOSOME BIOGENESIS PROTEIN BOP1 ribonucleoprotein complex binding#GO:0043021;protein-containing complex binding#GO:0044877;binding#GO:0005488 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of LSU-rRNA#GO:0000470;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;preribosome, large subunit precursor#GO:0030687;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981;90S preribosome#GO:0030686;nuclear protein-containing complex#GO:0140513 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG173374|UniProtKB=T1F6Q8 T1F6Q8 20204507 PTHR11362:SF82 PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4 protease inhibitor#PC00191 EGF receptor signaling pathway#P00018>RKIP#P00548;FGF signaling pathway#P00021>RKIP#P00630 HELRO|EnsemblGenome=HelroG155212|UniProtKB=T1ELH6 T1ELH6 20197426 PTHR34179:SF1 TUMOR PROTEIN P53-INDUCIBLE PROTEIN 13 TUMOR PROTEIN P53-INDUCIBLE PROTEIN 13 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG170808|UniProtKB=T1F3G5 T1F3G5 20203364 PTHR22906:SF55 PROPERDIN EGF-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG155673|UniProtKB=T1ELK3 T1ELK3 20197453 PTHR46012:SF2 IP22168P IP22168P UDP-xylosyltransferase activity#GO:0035252;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;xylosyltransferase activity#GO:0042285;pentosyltransferase activity#GO:0016763;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein glycosylation#GO:0006486;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycosylation#GO:0070085;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG189762|UniProtKB=T1FRC7 T1FRC7 20211374 PTHR12363:SF42 TRANSPORTIN 3 AND IMPORTIN 13 TRANSPORTIN-3 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;protein import into nucleus#GO:0006606;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365;nuclear transport#GO:0051169;import into nucleus#GO:0051170 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG90657|UniProtKB=T1G7U0 T1G7U0 20217137 PTHR24416:SF566 TYROSINE-PROTEIN KINASE RECEPTOR EPIDERMAL GROWTH FACTOR RECEPTOR signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 negative regulation of biological process#GO:0048519;signal transduction#GO:0007165;neurogenesis#GO:0022008;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;positive regulation of cell population proliferation#GO:0008284;regulation of catalytic activity#GO:0050790;nervous system development#GO:0007399;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;system development#GO:0048731;cell differentiation#GO:0030154;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;negative regulation of programmed cell death#GO:0043069;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;regulation of programmed cell death#GO:0043067;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;cellular developmental process#GO:0048869;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;regulation of apoptotic process#GO:0042981;regulation of cell population proliferation#GO:0042127;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;negative regulation of apoptotic process#GO:0043066;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;anatomical structure development#GO:0048856;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 basal plasma membrane#GO:0009925;receptor complex#GO:0043235;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;basal part of cell#GO:0045178;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 EGF receptor signaling pathway#P00018>EGFR#P00542;Cadherin signaling pathway#P00012>EGFR#P00466 HELRO|EnsemblGenome=HelroG65840|UniProtKB=T1FYD3 T1FYD3 20213831 PTHR45832:SF22 SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED HELRO|EnsemblGenome=HelroG193217|UniProtKB=T1FUR5 T1FUR5 20212561 PTHR11003:SF334 POTASSIUM CHANNEL, SUBFAMILY K FI03418P monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG82683|UniProtKB=T1G4V2 T1G4V2 20216100 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183383|UniProtKB=T1FJJ5 T1FJJ5 20208994 PTHR24543:SF291 MULTICOPPER OXIDASE-RELATED SMOKE ALARM, ISOFORM D oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG161513|UniProtKB=T1ERK7 T1ERK7 20199207 PTHR46516:SF1 TRNA-SPECIFIC ADENOSINE DEAMINASE 1 TRNA-SPECIFIC ADENOSINE DEAMINASE 1 hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;adenosine deaminase activity#GO:0004000;tRNA-specific adenosine deaminase activity#GO:0008251;deaminase activity#GO:0019239;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG188680|UniProtKB=T1FQ89 T1FQ89 20210986 PTHR10807:SF128 MYOTUBULARIN-RELATED PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG190087|UniProtKB=T1FRP0 T1FRP0 20211487 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG190373|UniProtKB=T1FRX9 T1FRX9 20211576 PTHR13014:SF3 MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S30/P52 PRO-APOTOTIC PROTEIN LARGE RIBOSOMAL SUBUNIT PROTEIN ML65 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrial large ribosomal subunit#GO:0005762;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;organellar ribosome#GO:0000313;protein-containing complex#GO:0032991;large ribosomal subunit#GO:0015934;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840;mitochondrial protein-containing complex#GO:0098798 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG74951|UniProtKB=T1G1Y4 T1G1Y4 20215082 PTHR19143:SF444 FIBRINOGEN/TENASCIN/ANGIOPOEITIN PROTEIN SCABROUS external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG63046|UniProtKB=T1FXA3 T1FXA3 20213451 PTHR45445:SF2 FAMILY NOT NAMED METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG117141|UniProtKB=T1EGK5 T1EGK5 20195706 PTHR46756:SF18 TRANSGELIN GAS2-LIKE PROTEIN PICKLED EGGS cytoskeletal protein binding#GO:0008092;molecular adaptor activity#GO:0060090;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;actin filament binding#GO:0051015;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 supramolecular complex#GO:0099080;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;supramolecular fiber#GO:0099512;supramolecular polymer#GO:0099081;actin filament#GO:0005884;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG165702|UniProtKB=T1EX69 T1EX69 20201169 PTHR23352:SF2 NEURAL PROLIFERATION DIFFERENTIATION AND CONTROL PROTEIN-1 NPDC-1 PROTEIN NEURAL PROLIFERATION DIFFERENTIATION AND CONTROL PROTEIN 1 HELRO|EnsemblGenome=HelroG73781|UniProtKB=T1G1I3 T1G1I3 20214931 PTHR23119:SF51 DISCS LARGE DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN enzyme binding#GO:0019899;protein binding#GO:0005515;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900 establishment or maintenance of cell polarity#GO:0007163;localization within membrane#GO:0051668;cellular localization#GO:0051641;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;developmental process#GO:0032502;multicellular organism development#GO:0007275;cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987;protein localization#GO:0008104;localization#GO:0051179;embryo development#GO:0009790;cellular macromolecule localization#GO:0070727;anatomical structure development#GO:0048856;establishment or maintenance of apical/basal cell polarity#GO:0035088;multicellular organismal process#GO:0032501;receptor clustering#GO:0043113;establishment or maintenance of bipolar cell polarity#GO:0061245;protein-containing complex localization#GO:0031503 basal plasma membrane#GO:0009925;basolateral plasma membrane#GO:0016323;cell junction#GO:0030054;plasma membrane region#GO:0098590;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;basal part of cell#GO:0045178;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG105347|UniProtKB=T1EDT9 T1EDT9 20194741 PTHR24223:SF443 ATP-BINDING CASSETTE SUB-FAMILY C MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG185793|UniProtKB=T1FNA6 T1FNA6 20210303 PTHR11748:SF111 D-LACTATE DEHYDROGENASE D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;flavin adenine dinucleotide binding#GO:0050660;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 organic hydroxy compound metabolic process#GO:1901615;oxoacid metabolic process#GO:0043436;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;carboxylic acid metabolic process#GO:0019752;small molecule metabolic process#GO:0044281;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;monocarboxylic acid catabolic process#GO:0072329 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG63683|UniProtKB=T1FXJ0 T1FXJ0 20213538 PTHR13463:SF3 PROTEIN C10 PROTEIN C10 multicellular organismal process#GO:0032501;anatomical structure development#GO:0048856;post-embryonic development#GO:0009791;multicellular organism development#GO:0007275;developmental process#GO:0032502 HELRO|EnsemblGenome=HelroG169408|UniProtKB=T1F1W7 T1F1W7 20202817 PTHR46641:SF25 FMRFAMIDE RECEPTOR-RELATED CNMAMIDE RECEPTOR-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG143740|UniProtKB=T1EJC0 T1EJC0 20196670 PTHR13286:SF6 SAP30 HISTONE DEACETYLASE COMPLEX SUBUNIT SAP30L-RELATED molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;histone deacetylase complex#GO:0000118;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG156044|UniProtKB=T1ELR0 T1ELR0 20197510 PTHR34524:SF6 CALCYPHOSIN CALCYPHOSINE LIKE calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG77483|UniProtKB=T1G2Y4 T1G2Y4 20215432 PTHR11920:SF501 GUANYLYL CYCLASE GUANYLATE CYCLASE 32E adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG185344|UniProtKB=T1FMP6 T1FMP6 20210095 PTHR13904:SF0 PRE-MRNA SPLICING FACTOR PRP31 U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical entity#GO:0110165;organelle#GO:0043226;U4 snRNP#GO:0005687;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;spliceosomal tri-snRNP complex#GO:0097526;membrane-bounded organelle#GO:0043227;precatalytic spliceosome#GO:0071011;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG161883|UniProtKB=T1ES00 T1ES00 20199350 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG192257|UniProtKB=T1FTR8 T1FTR8 20212215 PTHR12975:SF6 TRANSPORT PROTEIN TRAPP TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;vesicle tethering complex#GO:0099023;TRAPP complex#GO:0030008;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG191309|UniProtKB=T1FSV4 T1FSV4 20211901 PTHR18934:SF136 ATP-DEPENDENT RNA HELICASE ATP-DEPENDENT RNA HELICASE DHX35-RELATED nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640 cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG157627|UniProtKB=T1EME2 T1EME2 20197742 PTHR16160:SF13 FERMITIN 2-RELATED FERMITIN 2-RELATED cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;integrin binding#GO:0005178;binding#GO:0005488;signaling receptor binding#GO:0005102 cell adhesion#GO:0007155;cellular process#GO:0009987;cell-matrix adhesion#GO:0007160;cell-substrate adhesion#GO:0031589 cell junction#GO:0030054;cell-substrate junction#GO:0030055;cellular anatomical entity#GO:0110165;anchoring junction#GO:0070161 HELRO|EnsemblGenome=HelroG186777|UniProtKB=T1FP34 T1FP34 20210581 PTHR10687:SF2 SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN localization#GO:0051179;organic substance transport#GO:0071702;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;protein transport#GO:0015031;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 bounding membrane of organelle#GO:0098588;trans-Golgi network#GO:0005802;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;trans-Golgi network membrane#GO:0032588;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;recycling endosome membrane#GO:0055038;organelle#GO:0043226;endosome membrane#GO:0010008;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;recycling endosome#GO:0055037;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791;cytoplasmic vesicle membrane#GO:0030659 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG69195|UniProtKB=T1FZQ8 T1FZQ8 20214306 PTHR15454:SF73 NISCHARIN RELATED DYNEIN AXONEMAL LIGHT CHAIN 1 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG177810|UniProtKB=T1FCA8 T1FCA8 20206457 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG185327|UniProtKB=T1FMP1 T1FMP1 20210090 PTHR11627:SF80 FRUCTOSE-BISPHOSPHATE ALDOLASE FRUCTOSE-BISPHOSPHATE ALDOLASE-RELATED aldolase#PC00044;lyase#PC00144 Glycolysis#P00024>Aldolase#P00679;Fructose galactose metabolism#P02744>Fructose bisphosphate aldolase#P02959 HELRO|EnsemblGenome=HelroG156430|UniProtKB=T1ELW5 T1ELW5 20197565 PTHR13180:SF0 SMALL MEMBRANE PROTEIN-RELATED TRANSMEMBRANE PROTEIN 50A endosomal transport#GO:0016197;establishment of protein localization to vacuole#GO:0072666;cellular localization#GO:0051641;macromolecule localization#GO:0033036;protein targeting to vacuole#GO:0006623;vacuolar transport#GO:0007034;transport#GO:0006810;protein localization to vacuole#GO:0072665;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;protein targeting#GO:0006605;nitrogen compound transport#GO:0071705;late endosome to vacuole transport#GO:0045324;establishment of protein localization to organelle#GO:0072594;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;endosome transport via multivesicular body sorting pathway#GO:0032509;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;protein localization to organelle#GO:0033365;intracellular transport#GO:0046907 HELRO|EnsemblGenome=HelroG189206|UniProtKB=T1FQS6 T1FQS6 20211173 PTHR15907:SF204 DUF614 FAMILY PROTEIN-RELATED SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG158537|UniProtKB=T1EMX7 T1EMX7 20197927 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG67067|UniProtKB=T1FYV8 T1FYV8 20214006 PTHR24346:SF74 MAP/MICROTUBULE AFFINITY-REGULATING KINASE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;microtubule cytoskeleton organization#GO:0000226;cell communication#GO:0007154;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;regulation of cellular process#GO:0050794;organelle organization#GO:0006996;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;intracellular signal transduction#GO:0035556;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG169962|UniProtKB=T1F2H5 T1F2H5 20203025 PTHR19282:SF515 TETRASPANIN TETRASPANIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG108429|UniProtKB=T1EEI8 T1EEI8 20194990 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;heme binding#GO:0020037 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG77628|UniProtKB=T1G311 T1G311 20215459 PTHR11920:SF501 GUANYLYL CYCLASE GUANYLATE CYCLASE 32E adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG84128|UniProtKB=T1G5F0 T1G5F0 20216297 PTHR10933:SF9 IMMUNOGLOBULIN-BINDING PROTEIN 1 IMMUNOGLOBULIN-BINDING PROTEIN 1 phosphatase binding#GO:0019902;enzyme binding#GO:0019899;protein binding#GO:0005515;protein phosphatase binding#GO:0019903;binding#GO:0005488 regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;regulation of phosphate metabolic process#GO:0019220;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of dephosphorylation#GO:0035303;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG71418|UniProtKB=T1G0L3 T1G0L3 20214611 PTHR24347:SF393 SERINE/THREONINE-PROTEIN KINASE SPAGHETTI-SQUASH ACTIVATOR, ISOFORM C transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>MLCK#P00877;Cytoskeletal regulation by Rho GTPase#P00016>MLCK#P00514 HELRO|EnsemblGenome=HelroG174170|UniProtKB=T1F7Q5 T1F7Q5 20204854 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG189871|UniProtKB=T1FRF6 T1FRF6 20211403 PTHR13032:SF6 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21 cellular localization#GO:0051641;transmembrane transport#GO:0055085;macromolecule localization#GO:0033036;transport#GO:0006810;protein transmembrane transport#GO:0071806;protein targeting#GO:0006605;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;protein localization to mitochondrion#GO:0070585;cellular process#GO:0009987;protein transmembrane import into intracellular organelle#GO:0044743;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;mitochondrial transport#GO:0006839;organic substance transport#GO:0071702;protein import into mitochondrial matrix#GO:0030150;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein targeting to mitochondrion#GO:0006626;establishment of protein localization to mitochondrion#GO:0072655;protein transport#GO:0015031;protein localization to organelle#GO:0033365;mitochondrial transmembrane transport#GO:1990542 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;TIM23 mitochondrial import inner membrane translocase complex#GO:0005744;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;mitochondrial protein-containing complex#GO:0098798 HELRO|EnsemblGenome=HelroG161270|UniProtKB=T1ER99 T1ER99 20199099 PTHR15073:SF1 MICROTUBULE-ASSOCIATED PROTEIN RETICULOCYTE-BINDING PROTEIN HOMOLOG 2A cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG174066|UniProtKB=T1F7J8 T1F7J8 20204797 PTHR11461:SF211 SERINE PROTEASE INHIBITOR, SERPIN GH10112P-RELATED protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG163142|UniProtKB=T1ETQ0 T1ETQ0 20199950 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG113471|UniProtKB=T1EFS7 T1EFS7 20195429 PTHR11550:SF0 CTP SYNTHASE CTP SYNTHASE-RELATED identical protein binding#GO:0042802;ligase activity#GO:0016874;protein binding#GO:0005515;binding#GO:0005488;catalytic activity#GO:0003824 ribonucleoside triphosphate metabolic process#GO:0009199;cellular aromatic compound metabolic process#GO:0006725;nucleoside triphosphate metabolic process#GO:0009141;pyrimidine nucleotide metabolic process#GO:0006220;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;pyrimidine-containing compound metabolic process#GO:0072527;biosynthetic process#GO:0009058;nucleobase metabolic process#GO:0009112;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;nucleotide biosynthetic process#GO:0009165;pyrimidine nucleobase metabolic process#GO:0006206;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;ribonucleoside triphosphate biosynthetic process#GO:0009201;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 ligase#PC00142;metabolite interconversion enzyme#PC00262 De novo pyrimidine ribonucleotides biosythesis#P02740>CTP synthase#P02931 HELRO|EnsemblGenome=HelroG69274|UniProtKB=T1FZS7 T1FZS7 20214325 PTHR13047:SF0 PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 5 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159;mRNA 3'-UTR binding#GO:0003730 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mRNA processing#GO:0006397;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;mRNA cleavage factor complex#GO:0005849;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG174894|UniProtKB=T1F8L1 T1F8L1 20205160 PTHR22969:SF17 IKB KINASE INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;peptidyl-amino acid modification#GO:0018193;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;nitrogen compound metabolic process#GO:0006807;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Apoptosis signaling pathway#P00006>IKK#P00313 HELRO|EnsemblGenome=HelroG183471|UniProtKB=T1FJQ6 T1FJQ6 20209055 PTHR13145:SF0 SSM4 PROTEIN E3 UBIQUITIN-PROTEIN LIGASE MARCHF6 response to organic substance#GO:0010033;macromolecule catabolic process#GO:0009057;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;response to organonitrogen compound#GO:0010243;ERAD pathway#GO:0036503;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG110881|UniProtKB=T1EF61 T1EF61 20195213 PTHR23069:SF0 AAA DOMAIN-CONTAINING TAT-BINDING HOMOLOG 7 pyrophosphatase activity#GO:0016462;ATP-dependent activity#GO:0140657;chromatin binding#GO:0003682;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;ATP hydrolysis activity#GO:0016887;ribonucleoside triphosphate phosphatase activity#GO:0017111;histone binding#GO:0042393 positive regulation of gene expression#GO:0010628;cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;cellular component biogenesis#GO:0044085;nucleosome organization#GO:0034728;protein-DNA complex organization#GO:0071824;nucleosome assembly#GO:0006334;RNA metabolic process#GO:0016070;positive regulation of cellular metabolic process#GO:0031325;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;transcription initiation at RNA polymerase II promoter#GO:0006367;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;cellular component disassembly#GO:0022411;positive regulation of metabolic process#GO:0009893;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;cellular nitrogen compound biosynthetic process#GO:0044271;DNA-templated transcription initiation#GO:0006352;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;protein-containing complex disassembly#GO:0032984;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;positive regulation of cellular biosynthetic process#GO:0031328;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;organic cyclic compound biosynthetic process#GO:1901362;epigenetic regulation of gene expression#GO:0040029;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;positive regulation of cellular process#GO:0048522;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;transcription by RNA polymerase II#GO:0006366;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG153366|UniProtKB=T1EL51 T1EL51 20197301 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176030|UniProtKB=T1FA20 T1FA20 20205669 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167863|UniProtKB=T1EZW4 T1EZW4 20202114 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG125879|UniProtKB=T1EH74 T1EH74 20195924 PTHR23291:SF47 BAX INHIBITOR-RELATED TRANSMEMBRANE BAX INHIBITOR MOTIF CONTAINING 7 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG184875|UniProtKB=T1FM41 T1FM41 20209890 PTHR10953:SF162 UBIQUITIN-ACTIVATING ENZYME E1 SUMO-ACTIVATING ENZYME SUBUNIT 1 ligase activity#GO:0016874;transferase activity#GO:0016740;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877;nucleotidyltransferase activity#GO:0016779;thiosulfate sulfurtransferase activity#GO:0004792;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity, acting on a protein#GO:0140096;sulfurtransferase activity#GO:0016783 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;protein sumoylation#GO:0016925;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E1#P01492 HELRO|EnsemblGenome=HelroG84764|UniProtKB=T1G5N4 T1G5N4 20216381 PTHR46403:SF1 TP53-REGULATED INHIBITOR OF APOPTOSIS 1 TP53-REGULATED INHIBITOR OF APOPTOSIS 1 phospholipid transporter activity#GO:0005548;lipid transfer activity#GO:0120013;transporter activity#GO:0005215;lipid transporter activity#GO:0005319 organophosphate ester transport#GO:0015748;macromolecule localization#GO:0033036;membrane organization#GO:0061024;transport#GO:0006810;cellular component organization#GO:0016043;regulation of membrane lipid distribution#GO:0097035;phospholipid transport#GO:0015914;cellular process#GO:0009987;lipid transport#GO:0006869;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;biological regulation#GO:0065007;lipid translocation#GO:0034204;lipid localization#GO:0010876;phospholipid translocation#GO:0045332 envelope#GO:0031975;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;cytosol#GO:0005829;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;mitochondrial intermembrane space#GO:0005758 HELRO|EnsemblGenome=HelroG155224|UniProtKB=T1ELH7 T1ELH7 20197427 PTHR12682:SF11 ARCHEASE PROTEIN ARCHEASE HELRO|EnsemblGenome=HelroG159885|UniProtKB=T1EPI0 T1EPI0 20198480 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG67429|UniProtKB=T1FZ08 T1FZ08 20214056 PTHR11630:SF66 DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER DNA REPLICATION LICENSING FACTOR MCM4 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG192619|UniProtKB=T1FU48 T1FU48 20212344 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG116381|UniProtKB=T1EGE4 T1EGE4 20195646 PTHR15822:SF4 TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN TYROSYL-DNA PHOSPHODIESTERASE 2 HELRO|EnsemblGenome=HelroG81148|UniProtKB=T1G4A2 T1G4A2 20215900 PTHR11135:SF0 HISTONE ACETYLTRANSFERASE-RELATED ELONGATOR COMPLEX PROTEIN 3 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;tRNA wobble uridine modification#GO:0002098;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG159578|UniProtKB=T1EP66 T1EP66 20198366 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193353|UniProtKB=T1FUW6 T1FUW6 20212612 PTHR10165:SF174 LIPID PHOSPHATE PHOSPHATASE PHOSPHATIDIC ACID PHOSPHATASE TYPE 2_HALOPEROXIDASE DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 phospholipid dephosphorylation#GO:0046839;lipid metabolic process#GO:0006629;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;cellular metabolic process#GO:0044237;cell communication#GO:0007154;lipid modification#GO:0030258;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;dephosphorylation#GO:0016311;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG87051|UniProtKB=T1G6L1 T1G6L1 20216708 PTHR45746:SF6 LP21163P LP21163P nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of cell communication#GO:0010646;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;regulation of signaling#GO:0023051;positive regulation of molecular function#GO:0044093;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;regulation of molecular function#GO:0065009;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731 HELRO|EnsemblGenome=HelroG81686|UniProtKB=T1G4H4 T1G4H4 20215972 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG75608|UniProtKB=T1G273 T1G273 20215171 PTHR24349:SF179 SERINE/THREONINE-PROTEIN KINASE MAP KINASE-ACTIVATED PROTEIN KINASE 5 transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein serine/threonine kinase activity#GO:0004674;enzyme binding#GO:0019899;protein binding#GO:0005515;calmodulin binding#GO:0005516;protein kinase binding#GO:0019901;mitogen-activated protein kinase binding#GO:0051019;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;kinase binding#GO:0019900;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;small GTPase-mediated signal transduction#GO:0007264;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;Ras protein signal transduction#GO:0007265;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG91570|UniProtKB=T1G857 T1G857 20217254 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;heme binding#GO:0020037 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG165046|UniProtKB=T1EW70 T1EW70 20200820 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180615|UniProtKB=T1FG34 T1FG34 20207783 PTHR11954:SF6 D-DOPACHROME DECARBOXYLASE MACROPHAGE MIGRATION INHIBITORY FACTOR isomerase activity#GO:0016853;catalytic activity#GO:0003824 extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 decarboxylase#PC00089;lyase#PC00144 HELRO|EnsemblGenome=HelroG142999|UniProtKB=T1EJ85 T1EJ85 20196635 PTHR10390:SF61 HOMEOBOX PROTEIN SIX HOMEOBOX PROTEIN SIX2 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG94922|UniProtKB=T1G939 T1G939 20217586 PTHR43294:SF13 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium ion transmembrane transporter activity#GO:0015079;sodium ion transmembrane transporter activity#GO:0015081;P-type ion transporter activity#GO:0015662;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075 inorganic ion homeostasis#GO:0098771;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;proton transmembrane transport#GO:1902600;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;sodium ion homeostasis#GO:0055078;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;import into cell#GO:0098657;monoatomic cation transmembrane transport#GO:0098655;export from cell#GO:0140352;sodium ion transmembrane transport#GO:0035725;potassium ion import across plasma membrane#GO:1990573;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG168024|UniProtKB=T1F027 T1F027 20202177 PTHR47160:SF5 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG91852|UniProtKB=T1G898 T1G898 20217295 PTHR11552:SF147 GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE CHOLINE DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG125499|UniProtKB=T1EH63 T1EH63 20195913 PTHR24393:SF34 ZINC FINGER PROTEIN PR_SET DOMAIN 13 DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG187011|UniProtKB=T1FP56 T1FP56 20210603 PTHR23503:SF8 SOLUTE CARRIER FAMILY 2 FACILITATED GLUCOSE TRANSPORTER PROTEIN 1 transmembrane transporter activity#GO:0022857;sugar transmembrane transporter activity#GO:0051119;transporter activity#GO:0005215;carbohydrate transmembrane transporter activity#GO:0015144 localization#GO:0051179;organic substance transport#GO:0071702;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;cellular process#GO:0009987;carbohydrate transmembrane transport#GO:0034219;carbohydrate transport#GO:0008643 cellular anatomical entity#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG90723|UniProtKB=T1G7V1 T1G7V1 20217148 PTHR43272:SF32 LONG-CHAIN-FATTY-ACID--COA LIGASE AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN long-chain fatty acid-CoA ligase activity#GO:0004467;ligase activity#GO:0016874;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG157365|UniProtKB=T1EMA3 T1EMA3 20197703 PTHR23430:SF7 HISTONE H2A HISTONE H2A.V nucleosome binding#GO:0031491;nucleic acid binding#GO:0003676;chromatin DNA binding#GO:0031490;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;protein-containing complex binding#GO:0044877 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;protein-DNA complex organization#GO:0071824;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;heterochromatin formation#GO:0031507;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;negative regulation of gene expression, epigenetic#GO:0045814;cellular process#GO:0009987;epigenetic regulation of gene expression#GO:0040029;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;heterochromatin organization#GO:0070828;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG192895|UniProtKB=T1FUE2 T1FUE2 20212438 PTHR10671:SF82 EPITHELIAL MEMBRANE PROTEIN-RELATED GH19567P cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG186265|UniProtKB=T1FNW1 T1FNW1 20210508 PTHR12683:SF13 CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1 CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;regulation of DNA-templated transcription#GO:0006355;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;primary metabolic process#GO:0044238;regulation of primary metabolic process#GO:0080090;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;regulation of cellular biosynthetic process#GO:0031326;response to stress#GO:0006950;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;cellular response to stress#GO:0033554;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;DNA-directed RNA polymerase complex#GO:0000428;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nucleoplasm#GO:0005654;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;serine/threonine protein kinase complex#GO:1902554;RNA polymerase II transcription regulator complex#GO:0090575;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;transcription regulator complex#GO:0005667;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;transcription factor TFIIH holo complex#GO:0005675;nuclear protein-containing complex#GO:0140513 chaperone#PC00072 HELRO|EnsemblGenome=HelroG156339|UniProtKB=T1ELU0 T1ELU0 20197540 PTHR15893:SF0 RIBOSOMAL PROTEIN L27 LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG110719|UniProtKB=T1EF44 T1EF44 20195196 PTHR10806:SF6 SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11 SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11 serine protease#PC00203;protein modifying enzyme#PC00260 Endothelin signaling pathway#P00019>signal peptidase#P00573;Vasopressin synthesis#P04395>Signal Peptidase#P04589 HELRO|EnsemblGenome=HelroG76519|UniProtKB=T1G2K9 T1G2K9 20215307 PTHR44899:SF7 CAMK FAMILY PROTEIN KINASE NIMA-RELATED KINASE non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG67821|UniProtKB=T1FZ58 T1FZ58 20214106 PTHR45969:SF69 RING ZINC FINGER PROTEIN-RELATED FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG116840|UniProtKB=T1EGI3 T1EGI3 20195685 PTHR11884:SF1 SELECTIN LIGAND RELATED GOLGI APPARATUS PROTEIN 1 HELRO|EnsemblGenome=HelroG81689|UniProtKB=T1G4H5 T1G4H5 20215973 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG152254|UniProtKB=T1EKQ2 T1EKQ2 20197152 PTHR12276:SF115 EPSIN/ENT-RELATED FI19443P1 protein binding#GO:0005515;lipid binding#GO:0008289;clathrin binding#GO:0030276;phospholipid binding#GO:0005543;binding#GO:0005488 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;import into cell#GO:0098657;transport#GO:0006810;endocytosis#GO:0006897 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;clathrin vesicle coat#GO:0030125;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;vesicle coat#GO:0030120;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;clathrin-coated vesicle#GO:0030136;endomembrane system#GO:0012505;membrane coat#GO:0030117;coated vesicle membrane#GO:0030662;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;coated membrane#GO:0048475;cytoplasmic vesicle membrane#GO:0030659;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG76975|UniProtKB=T1G2S1 T1G2S1 20215369 PTHR48034:SF6 TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED TRANSFORMER-2 SEX-DETERMINING PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 positive regulation of gene expression#GO:0010628;positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of mRNA metabolic process#GO:1903313;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of mRNA processing#GO:0050684;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule biosynthetic process#GO:0010556;regulation of mRNA splicing, via spliceosome#GO:0048024;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG194962|UniProtKB=T1FWL9 T1FWL9 20213214 PTHR21615:SF2 CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN 1 CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN 1 Cell cycle#P00013>Proteasome#P00480 HELRO|EnsemblGenome=HelroG113765|UniProtKB=T1EFW0 T1EFW0 20195462 PTHR23326:SF1 CCR4 NOT-RELATED CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 3 negative regulation of gene expression#GO:0010629;regulation of catabolic process#GO:0009894;heterocycle catabolic process#GO:0046700;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;nucleobase-containing compound metabolic process#GO:0006139;RNA destabilization#GO:0050779;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;regulation of biological quality#GO:0065008;nitrogen compound metabolic process#GO:0006807;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;positive regulation of mRNA catabolic process#GO:0061014;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of catabolic process#GO:0009896;mRNA destabilization#GO:0061157;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323;positive regulation of nitrogen compound metabolic process#GO:0051173;cellular aromatic compound metabolic process#GO:0006725;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;RNA metabolic process#GO:0016070;positive regulation of cellular catabolic process#GO:0031331;cellular nitrogen compound catabolic process#GO:0044270;organic cyclic compound metabolic process#GO:1901360;positive regulation of metabolic process#GO:0009893;mRNA catabolic process#GO:0006402;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;positive regulation of mRNA metabolic process#GO:1903313;heterocycle metabolic process#GO:0046483;negative regulation of biosynthetic process#GO:0009890;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of cellular catabolic process#GO:0031329;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;positive regulation of RNA metabolic process#GO:0051254 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;protein-containing complex#GO:0032991;P-body#GO:0000932;CCR4-NOT complex#GO:0030014;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular anatomical structure#GO:0005622 general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG187144|UniProtKB=T1FP72 T1FP72 20210619 PTHR10218:SF302 GTP-BINDING PROTEIN ALPHA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;ribonucleoside triphosphate phosphatase activity#GO:0017111;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 regulation of biological process#GO:0050789;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;side of membrane#GO:0098552;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;extrinsic component of membrane#GO:0019898 heterotrimeric G-protein#PC00117;G-protein#PC00020 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Galphai#P00828;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Galphai/q#P00873 HELRO|EnsemblGenome=HelroG62336|UniProtKB=T1FWZ7 T1FWZ7 20213345 PTHR43658:SF8 SHORT-CHAIN DEHYDROGENASE/REDUCTASE 17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG191499|UniProtKB=T1FT16 T1FT16 20211963 PTHR33590:SF1 GLUTENIN, HIGH MOLECULAR WEIGHT SUBUNIT PW212-RELATED PROTEIN PDZ DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG70729|UniProtKB=T1G0B3 T1G0B3 20214511 PTHR45793:SF5 HOMEOBOX PROTEIN HOMEOTIC PROTEIN OCELLILESS sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG67009|UniProtKB=T1FYV1 T1FYV1 20213999 PTHR15860:SF0 UNCHARACTERIZED RING FINGER-CONTAINING PROTEIN LP20373P transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 HELRO|EnsemblGenome=HelroG134296|UniProtKB=T1EI40 T1EI40 20196240 PTHR11214:SF364 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE HEXOSYLTRANSFERASE transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG63304|UniProtKB=T1FXD9 T1FXD9 20213487 PTHR45720:SF10 CHLORIDE CHANNEL PROTEIN 2 CHLORIDE CHANNEL PROTEIN 2 voltage-gated monoatomic ion channel activity#GO:0005244;inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267 localization#GO:0051179;chloride transport#GO:0006821;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;inorganic anion transport#GO:0015698;monoatomic anion transport#GO:0006820;transport#GO:0006810 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG67815|UniProtKB=T1FZ57 T1FZ57 20214105 PTHR22997:SF0 PIH1 DOMAIN-CONTAINING PROTEIN 1 PIH1 DOMAIN-CONTAINING PROTEIN 1 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG191912|UniProtKB=T1FTE8 T1FTE8 20212095 PTHR14463:SF5 LIPASE MATURATION FACTOR LIPASE MATURATION FACTOR 2 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG124318|UniProtKB=T1EH10 T1EH10 20195860 PTHR19282:SF534 TETRASPANIN TETRASPANIN FAMILY-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG136387|UniProtKB=T1EID8 T1EID8 20196338 PTHR22978:SF22 B-CELL TRANSLOCATION GENE BTG FAMILY PROTEIN cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG79596|UniProtKB=T1G3Q5 T1G3Q5 20215703 PTHR37079:SF4 SERINE/THREONINE-PROTEIN KINASE ATM SERINE_THREONINE-PROTEIN KINASE ATM non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG189305|UniProtKB=T1FQX9 T1FQX9 20211226 PTHR24408:SF58 ZINC FINGER PROTEIN TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG186276|UniProtKB=T1FNW5 T1FNW5 20210512 PTHR10634:SF149 AN1-TYPE ZINC FINGER PROTEIN AN1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG165464|UniProtKB=T1EWU5 T1EWU5 20201045 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174005|UniProtKB=T1F7G9 T1F7G9 20204768 PTHR11819:SF195 SOLUTE CARRIER FAMILY 5 SODIUM_GLUCOSE COTRANSPORTER 4 inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;carbohydrate transmembrane transporter activity#GO:0015144;symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;sugar transmembrane transporter activity#GO:0051119;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;monoatomic ion transmembrane transporter activity#GO:0015075;inorganic cation transmembrane transporter activity#GO:0022890;solute:monoatomic cation symporter activity#GO:0015294 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG112439|UniProtKB=T1EFK0 T1EFK0 20195352 PTHR43462:SF1 ALANYL-TRNA EDITING PROTEIN ALANYL-TRNA EDITING PROTEIN AARSD1 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG169610|UniProtKB=T1F259 T1F259 20202909 PTHR33332:SF48 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG80866|UniProtKB=T1G465 T1G465 20215863 PTHR11461:SF211 SERINE PROTEASE INHIBITOR, SERPIN GH10112P-RELATED protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG107533|UniProtKB=T1EEB0 T1EEB0 20194912 PTHR11153:SF14 SIDEROFLEXIN SIDEROFLEXIN-2 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 neutral amino acid transport#GO:0015804;transmembrane transport#GO:0055085;organic anion transport#GO:0015711;amino acid transport#GO:0006865;organic acid transport#GO:0015849;transport#GO:0006810;nitrogen compound transport#GO:0071705;carboxylic acid transport#GO:0046942;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039;mitochondrial transport#GO:0006839;localization#GO:0051179;organic substance transport#GO:0071702;amino acid transmembrane transport#GO:0003333;establishment of localization#GO:0051234;organic acid transmembrane transport#GO:1903825;mitochondrial transmembrane transport#GO:1990542 envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;organelle inner membrane#GO:0019866;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG97190|UniProtKB=T1G9F8 T1G9F8 20217705 PTHR23253:SF78 EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA EUKARYOTIC TRANSLATION INITIATION FACTOR 4G1, ISOFORM B-RELATED nucleic acid binding#GO:0003676;translation regulator activity#GO:0045182;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation initiation factor activity#GO:0003743;mRNA binding#GO:0003729;translation regulator activity, nucleic acid binding#GO:0090079;translation factor activity, RNA binding#GO:0008135 cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG85716|UniProtKB=T1G622 T1G622 20216519 PTHR43448:SF2 PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL prenyltransferase activity#GO:0004659;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824 tetrapyrrole metabolic process#GO:0033013;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;porphyrin-containing compound metabolic process#GO:0006778;cellular biosynthetic process#GO:0044249;pigment metabolic process#GO:0042440;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;heme biosynthetic process#GO:0006783;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;pigment biosynthetic process#GO:0046148;aromatic compound biosynthetic process#GO:0019438;heme metabolic process#GO:0042168;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 acyltransferase#PC00042 Heme biosynthesis#P02746>Protoheme IX farnesyl transferase#P02982 HELRO|EnsemblGenome=HelroG170842|UniProtKB=T1F3I1 T1F3I1 20203380 PTHR19964:SF92 MULTIPLE PDZ DOMAIN PROTEIN PATJ HOMOLOG scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG68914|UniProtKB=T1FZL0 T1FZL0 20214258 PTHR13710:SF153 DNA HELICASE RECQ FAMILY MEMBER RECQ-LIKE DNA HELICASE BLM ATP-dependent activity, acting on DNA#GO:0008094;3'-5' DNA helicase activity#GO:0043138;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;double-strand break repair#GO:0006302;nucleobase-containing compound metabolic process#GO:0006139;DNA geometric change#GO:0032392;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;recombinational repair#GO:0000725;DNA duplex unwinding#GO:0032508;DNA-templated DNA replication#GO:0006261;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;DNA unwinding involved in DNA replication#GO:0006268;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;double-strand break repair via homologous recombination#GO:0000724;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;DNA conformation change#GO:0071103;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;organelle organization#GO:0006996;chromosome organization#GO:0051276;cellular response to stress#GO:0033554;DNA replication#GO:0006260;DNA metabolic process#GO:0006259 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA helicase#PC00011;DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG194116|UniProtKB=T1FVP8 T1FVP8 20212894 PTHR10075:SF100 BASIGIN RELATED FASCICLIN-2 cell adhesion molecule binding#GO:0050839;cell-cell adhesion mediator activity#GO:0098632;protein binding#GO:0005515;binding#GO:0005488 neuron projection guidance#GO:0097485;cell recognition#GO:0008037;neurogenesis#GO:0022008;cell projection organization#GO:0030030;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;axonogenesis#GO:0007409;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156;cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cell morphogenesis#GO:0000902;cellular process#GO:0009987;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure development#GO:0048856;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;axon#GO:0030424 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG170968|UniProtKB=T1F3N0 T1F3N0 20203429 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG115530|UniProtKB=T1EG90 T1EG90 20195592 PTHR11252:SF0 POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;transferase activity#GO:0016740;catalytic activity#GO:0003824;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;nucleotidyltransferase activity#GO:0016779;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;3'-5'-RNA exonuclease activity#GO:0000175;exonuclease activity#GO:0004527;3'-5' exonuclease activity#GO:0008408;RNA nuclease activity#GO:0004540 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular nitrogen compound catabolic process#GO:0044270;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic cyclic compound catabolic process#GO:1901361;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;organic substance catabolic process#GO:1901575;nucleobase-containing compound catabolic process#GO:0034655;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 transferase#PC00220;nucleotidyltransferase#PC00174;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG183668|UniProtKB=T1FK06 T1FK06 20209155 PTHR11552:SF147 GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE CHOLINE DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG70505|UniProtKB=T1G073 T1G073 20214471 PTHR10779:SF3 DYNEIN LIGHT CHAIN ROADBLOCK DYNEIN LIGHT CHAIN ROADBLOCK-TYPE 2 protein binding#GO:0005515;binding#GO:0005488 microtubule-based movement#GO:0007018;cellular process#GO:0009987;microtubule-based process#GO:0007017 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;microtubule cytoskeleton#GO:0015630;dynein complex#GO:0030286;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic dynein complex#GO:0005868;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG161317|UniProtKB=T1ERB9 T1ERB9 20199119 PTHR11388:SF142 ORGANIC ANION TRANSPORTER SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 5A1 secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;organic substance transport#GO:0071702;establishment of localization#GO:0051234;organic anion transport#GO:0015711;transport#GO:0006810 basal plasma membrane#GO:0009925;basolateral plasma membrane#GO:0016323;plasma membrane region#GO:0098590;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;basal part of cell#GO:0045178;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG114519|UniProtKB=T1EG23 T1EG23 20195525 PTHR12455:SF0 NUCLEOLAR COMPLEX PROTEIN 4 NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG membrane-enclosed lumen#GO:0031974;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;preribosome, small subunit precursor#GO:0030688;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;preribosome#GO:0030684;nuclear protein-containing complex#GO:0140513;90S preribosome#GO:0030686 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG161469|UniProtKB=T1ERI1 T1ERI1 20199181 PTHR15093:SF1 PROSTATE APOPTOSIS RESPONSE PROTEIN PAR-4 PRKC APOPTOSIS WT1 REGULATOR PROTEIN HELRO|EnsemblGenome=HelroG177261|UniProtKB=T1FBF1 T1FBF1 20206150 PTHR19282:SF431 TETRASPANIN TETRASPANIN 26A, ISOFORM B-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG105809|UniProtKB=T1EDX7 T1EDX7 20194779 PTHR20961:SF38 GLYCOSYLTRANSFERASE PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2 transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG185662|UniProtKB=T1FN39 T1FN39 20210237 PTHR11224:SF10 MAKORIN-RELATED IP09428P-RELATED transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG179184|UniProtKB=T1FEB5 T1FEB5 20207164 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG65850|UniProtKB=T1FYD6 T1FYD6 20213834 PTHR10736:SF65 BESTROPHIN BESTROPHIN 1, ISOFORM C-RELATED inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;channel activity#GO:0015267 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG194640|UniProtKB=T1FW96 T1FW96 20213092 PTHR15688:SF1 KINETOCHORE-ASSOCIATED PROTEIN 1 KINETOCHORE-ASSOCIATED PROTEIN 1 enzyme binding#GO:0019899;protein binding#GO:0005515;small GTPase binding#GO:0031267;binding#GO:0005488 negative regulation of sister chromatid segregation#GO:0033046;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;regulation of mitotic nuclear division#GO:0007088;protein-DNA complex organization#GO:0071824;kinetochore organization#GO:0051383;regulation of chromosome segregation#GO:0051983;mitotic cell cycle checkpoint signaling#GO:0007093;nuclear division#GO:0000280;negative regulation of chromosome organization#GO:2001251;negative regulation of mitotic nuclear division#GO:0045839;regulation of cellular component organization#GO:0051128;protein-DNA complex assembly#GO:0065004;negative regulation of nuclear division#GO:0051784;negative regulation of mitotic sister chromatid segregation#GO:0033048;chromosome segregation#GO:0007059;regulation of biological process#GO:0050789;cell cycle checkpoint signaling#GO:0000075;mitotic cell cycle#GO:0000278;regulation of mitotic sister chromatid segregation#GO:0033047;intracellular signal transduction#GO:0035556;negative regulation of cellular component organization#GO:0051129;cellular component assembly#GO:0022607;nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;negative regulation of cell cycle#GO:0045786;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of organelle organization#GO:0033043;mitotic spindle assembly checkpoint signaling#GO:0007094;negative regulation of chromosome segregation#GO:0051985;regulation of cell cycle phase transition#GO:1901987;cellular component organization#GO:0016043;cell communication#GO:0007154;regulation of mitotic metaphase/anaphase transition#GO:0030071;regulation of cell cycle process#GO:0010564;protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;cellular macromolecule localization#GO:0070727;chromosome organization#GO:0051276;regulation of cellular process#GO:0050794;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100;negative regulation of mitotic sister chromatid separation#GO:2000816;signal transduction#GO:0007165;negative regulation of biological process#GO:0048519;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;macromolecule localization#GO:0033036;regulation of chromosome separation#GO:1905818;cell cycle process#GO:0022402;protein-containing complex assembly#GO:0065003;negative regulation of cell cycle process#GO:0010948;mitotic cell cycle process#GO:1903047;negative regulation of mitotic cell cycle phase transition#GO:1901991;protein localization to kinetochore#GO:0034501;negative regulation of organelle organization#GO:0010639;mitotic nuclear division#GO:0140014;protein localization to organelle#GO:0033365;mitotic sister chromatid segregation#GO:0000070;kinetochore assembly#GO:0051382;non-membrane-bounded organelle assembly#GO:0140694;signaling#GO:0023052;negative regulation of cellular process#GO:0048523;regulation of chromosome organization#GO:0033044;cellular response to stimulus#GO:0051716;regulation of mitotic sister chromatid separation#GO:0010965;regulation of nuclear division#GO:0051783;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of mitotic cell cycle#GO:0045930;cellular process#GO:0009987;localization#GO:0051179;organelle assembly#GO:0070925;response to stimulus#GO:0050896;negative regulation of chromosome separation#GO:1905819;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;organelle fission#GO:0048285;regulation of sister chromatid segregation#GO:0033045;regulation of mitotic cell cycle#GO:0007346 supramolecular complex#GO:0099080;spindle microtubule#GO:0005876;kinetochore#GO:0000776;condensed chromosome, centromeric region#GO:0000779;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;supramolecular fiber#GO:0099512;supramolecular polymer#GO:0099081;cellular anatomical entity#GO:0110165;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;microtubule cytoskeleton#GO:0015630;chromosomal region#GO:0098687;cytoskeleton#GO:0005856;spindle#GO:0005819;microtubule#GO:0005874 HELRO|EnsemblGenome=HelroG186192|UniProtKB=T1FNS8 T1FNS8 20210475 PTHR19300:SF57 BETA-1,4-GALACTOSYLTRANSFERASE BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE galactosyltransferase activity#GO:0008378;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycosylation#GO:0070085;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG178918|UniProtKB=T1FDW4 T1FDW4 20207013 PTHR19981:SF1 TALIN RHEA, ISOFORM B cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;cell-cell adhesion#GO:0098609;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cell adhesion#GO:0007155;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 cytoplasm#GO:0005737;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 Integrin signalling pathway#P00034>Talin#P00943 HELRO|EnsemblGenome=HelroG159456|UniProtKB=T1EP21 T1EP21 20198321 PTHR16008:SF6 F-BOX ONLY PROTEIN 4 SI:DKEY-12E7.1 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234 HELRO|EnsemblGenome=HelroG165195|UniProtKB=T1EWF0 T1EWF0 20200900 PTHR19303:SF71 TRANSPOSON ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG164180|UniProtKB=T1EV19 T1EV19 20200419 PTHR31705:SF4 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 30 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 30 molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HELRO|EnsemblGenome=HelroG87875|UniProtKB=T1G6W3 T1G6W3 20216810 PTHR47980:SF19 LD44762P RAS-RELATED PROTEIN RAB-3 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;cytoskeletal protein binding#GO:0008092;myosin binding#GO:0017022;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;ribonucleoside triphosphate phosphatase activity#GO:0017111 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;protein secretion#GO:0009306;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;establishment of protein localization to extracellular region#GO:0035592;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;protein transport#GO:0015031;protein localization to extracellular region#GO:0071692;export from cell#GO:0140352;secretion by cell#GO:0032940 presynapse#GO:0098793;synapse#GO:0045202;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;secretory vesicle#GO:0099503;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG182519|UniProtKB=T1FIB2 T1FIB2 20208561 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG87582|UniProtKB=T1G6S5 T1G6S5 20216772 PTHR24393:SF34 ZINC FINGER PROTEIN PR_SET DOMAIN 13 DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG193840|UniProtKB=T1FVE8 T1FVE8 20212794 PTHR24201:SF2 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 42 kinase modulator#PC00140;kinase inhibitor#PC00139 HELRO|EnsemblGenome=HelroG191092|UniProtKB=T1FSL1 T1FSL1 20211808 PTHR11309:SF47 FRIZZLED FRIZZLED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;protein binding#GO:0005515;Wnt-protein binding#GO:0017147;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;non-canonical Wnt signaling pathway#GO:0035567;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;cell-cell signaling by wnt#GO:0198738;canonical Wnt signaling pathway#GO:0060070;cell-cell signaling#GO:0007267;signaling#GO:0023052;Wnt signaling pathway#GO:0016055 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Angiogenesis#P00005>Fzd#P00189;Wnt signaling pathway#P00057>Frizzled#P01428;Alzheimer disease-presenilin pathway#P00004>Frizzled#P00119;Cadherin signaling pathway#P00012>Frizzled#P00475 HELRO|EnsemblGenome=HelroG88474|UniProtKB=T1G730 T1G730 20216877 PTHR23504:SF14 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 9 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG73843|UniProtKB=T1G1J1 T1G1J1 20214939 PTHR22951:SF5 CLATHRIN ASSEMBLY PROTEIN PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP phosphatidylinositol bisphosphate binding#GO:1902936;small molecule binding#GO:0036094;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;binding#GO:0005488;protein binding#GO:0005515;clathrin binding#GO:0030276;lipid binding#GO:0008289;ion binding#GO:0043167;anion binding#GO:0043168;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981;SNARE binding#GO:0000149 localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;vesicle budding from membrane#GO:0006900;establishment of localization#GO:0051234;membrane organization#GO:0061024;organelle organization#GO:0006996;clathrin-dependent endocytosis#GO:0072583;transport#GO:0006810;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;vesicle organization#GO:0016050;cellular component organization#GO:0016043;receptor-mediated endocytosis#GO:0006898;cellular process#GO:0009987;import into cell#GO:0098657 cytoplasm#GO:0005737;clathrin-coated vesicle#GO:0030136;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;clathrin-coated pit#GO:0005905;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG154960|UniProtKB=T1ELG7 T1ELG7 20197417 PTHR11848:SF263 TGF-BETA FAMILY PROTEIN DECAPENTAPLEGIC molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;binding#GO:0005488;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;protein binding#GO:0005515;signaling receptor binding#GO:0005102 extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 DPP signaling pathway#P06213>DPP#P06285;BMP/activin signaling pathway-drosophila#P06211>Full-length BMP orthologous ligand#P06256;DPP signaling pathway#P06213>DPP full length#P06282;TGF-beta signaling pathway#P00052>TGFbeta#P01286;DPP-SCW signaling pathway#P06212>DPP full length#P06273;DPP-SCW signaling pathway#P06212>DPP#P06272;BMP/activin signaling pathway-drosophila#P06211>BMP/activin orthologous ligand#P06251 HELRO|EnsemblGenome=HelroG85027|UniProtKB=T1G5R5 T1G5R5 20216412 PTHR13507:SF0 PRKR-INTERACTING PROTEIN 1 PRKR-INTERACTING PROTEIN 1 nucleic acid binding#GO:0003676;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;binding#GO:0005488;enzyme binding#GO:0019899;enzyme inhibitor activity#GO:0004857;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234;kinase binding#GO:0019900;RNA binding#GO:0003723;organic cyclic compound binding#GO:0097159;protein binding#GO:0005515;protein kinase binding#GO:0019901;molecular function inhibitor activity#GO:0140678;double-stranded RNA binding#GO:0003725;protein kinase inhibitor activity#GO:0004860 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;regulation of nitrogen compound metabolic process#GO:0051171;regulation of catalytic activity#GO:0050790;negative regulation of protein phosphorylation#GO:0001933;regulation of phosphorus metabolic process#GO:0051174;regulation of biological process#GO:0050789;negative regulation of protein modification process#GO:0031400;regulation of molecular function#GO:0065009;negative regulation of protein kinase activity#GO:0006469;negative regulation of cellular process#GO:0048523;regulation of kinase activity#GO:0043549;regulation of protein kinase activity#GO:0045859;negative regulation of phosphorus metabolic process#GO:0010563;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of primary metabolic process#GO:0080090;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of phosphorylation#GO:0042326;regulation of protein phosphorylation#GO:0001932;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of phosphate metabolic process#GO:0045936;regulation of phosphorylation#GO:0042325;negative regulation of catalytic activity#GO:0043086;regulation of transferase activity#GO:0051338;regulation of metabolic process#GO:0019222;negative regulation of molecular function#GO:0044092;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG192311|UniProtKB=T1FTT5 T1FTT5 20212232 PTHR22642:SF2 IMIDAZOLONEPROPIONASE PROTEIN LONG AFTER FAR-RED 3 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG161940|UniProtKB=T1ES21 T1ES21 20199371 PTHR21650:SF4 MEMBRALIN/KINETOCHORE PROTEIN NUF2 MEMBRALIN positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of protein metabolic process#GO:0051246;regulation of catabolic process#GO:0009894;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of proteasomal protein catabolic process#GO:1901800;regulation of protein catabolic process#GO:0042176;regulation of proteolysis involved in protein catabolic process#GO:1903050;positive regulation of proteolysis#GO:0045862;regulation of biological process#GO:0050789;positive regulation of response to stimulus#GO:0048584;regulation of cellular response to stress#GO:0080135;positive regulation of metabolic process#GO:0009893;positive regulation of biological process#GO:0048518;regulation of proteolysis#GO:0030162;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;positive regulation of proteolysis involved in protein catabolic process#GO:1903052;regulation of response to endoplasmic reticulum stress#GO:1905897;regulation of response to stress#GO:0080134;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of proteasomal protein catabolic process#GO:0061136;regulation of response to stimulus#GO:0048583;response to stimulus#GO:0050896;positive regulation of protein metabolic process#GO:0051247;response to stress#GO:0006950;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;positive regulation of catabolic process#GO:0009896;cellular response to stress#GO:0033554;positive regulation of protein catabolic process#GO:0045732;regulation of metabolic process#GO:0019222 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG175669|UniProtKB=T1F9I0 T1F9I0 20205479 PTHR15079:SF3 MYD88 MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88 scaffold/adaptor protein#PC00226 Toll pathway-drosophila#P06217>MyD88#P06346;Toll receptor signaling pathway#P00054>MyD88#P01377 HELRO|EnsemblGenome=HelroG147328|UniProtKB=T1EJZ4 T1EJZ4 20196894 PTHR46188:SF1 BOLA-LIKE PROTEIN 3 BOLA-LIKE PROTEIN 3 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG188883|UniProtKB=T1FQF6 T1FQF6 20211053 PTHR14894:SF0 CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3 CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3 biological regulation#GO:0065007;regulation of biological process#GO:0050789;regulation of cell cycle#GO:0051726;regulation of mitotic cell cycle#GO:0007346;regulation of cellular process#GO:0050794 cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG64937|UniProtKB=T1FY16 T1FY16 20213714 PTHR21347:SF14 CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED LIPID SCRAMBLASE CLPTM1-RELATED cellular anatomical entity#GO:0110165;membrane#GO:0016020;endomembrane system#GO:0012505 HELRO|EnsemblGenome=HelroG172749|UniProtKB=T1F5W6 T1F5W6 20204215 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184573|UniProtKB=T1FLI2 T1FLI2 20209681 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG187858|UniProtKB=T1FPF7 T1FPF7 20210704 PTHR20275:SF0 NAD KINASE NAD KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 cellular aromatic compound metabolic process#GO:0006725;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;pyridine nucleotide metabolic process#GO:0019362;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;nucleotide biosynthetic process#GO:0009165;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;NADP metabolic process#GO:0006739;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;nicotinamide nucleotide metabolic process#GO:0046496;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 nucleotide kinase#PC00172 HELRO|EnsemblGenome=HelroG77815|UniProtKB=T1G345 T1G345 20215493 PTHR11183:SF100 GLYCOGENIN SUBFAMILY MEMBER GLYCOGENIN, ISOFORM E transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG192532|UniProtKB=T1FU21 T1FU21 20212317 PTHR14592:SF14 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG153596|UniProtKB=T1EL89 T1EL89 20197339 PTHR12547:SF174 CCCH ZINC FINGER/TIS11-RELATED MRNA DECAY ACTIVATOR PROTEIN ZFP36L2 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG168935|UniProtKB=T1F157 T1F157 20202557 PTHR13802:SF52 MUCIN 4-RELATED MUCIN-4 HELRO|EnsemblGenome=HelroG96778|UniProtKB=T1G9D7 T1G9D7 20217684 PTHR18952:SF265 CARBONIC ANHYDRASE CARBONIC ANHYDRASE dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG185211|UniProtKB=T1FMI5 T1FMI5 20210034 PTHR43943:SF2 DEHYDROGENASE/REDUCTASE (SDR FAMILY) MEMBER 4 DEHYDROGENASE_REDUCTASE 4 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG155996|UniProtKB=T1ELQ6 T1ELQ6 20197506 PTHR11452:SF83 ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE ALPHA-GALACTOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 carbohydrate derivative metabolic process#GO:1901135;glycosyl compound catabolic process#GO:1901658;carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;glycosyl compound metabolic process#GO:1901657;carbohydrate metabolic process#GO:0005975;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 galactosidase#PC00104;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG135299|UniProtKB=T1EI79 T1EI79 20196279 PTHR13356:SF0 OB FOLD NUCLEIC ACID BINDING PROTEIN-RELATED SOSS COMPLEX SUBUNIT B HOMOLOG nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;double-strand break repair via homologous recombination#GO:0000724;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;response to radiation#GO:0009314;nitrogen compound metabolic process#GO:0006807;recombinational repair#GO:0000725;response to abiotic stimulus#GO:0009628;cellular response to stress#GO:0033554;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;organic substance metabolic process#GO:0071704 damaged DNA-binding protein#PC00086 HELRO|EnsemblGenome=HelroG192411|UniProtKB=T1FTX6 T1FTX6 20212273 PTHR21470:SF2 RAB6-INTERACTING PROTEIN GORAB RAB6-INTERACTING GOLGIN HELRO|EnsemblGenome=HelroG88660|UniProtKB=T1G751 T1G751 20216898 PTHR45936:SF1 TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor#GO:0016628 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG191577|UniProtKB=T1FT35 T1FT35 20211982 PTHR24388:SF86 ZINC FINGER PROTEIN BTB DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG70216|UniProtKB=T1G034 T1G034 20214432 PTHR14359:SF6 HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;carboxy-lyase activity#GO:0016831;carbon-carbon lyase activity#GO:0016830;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;lyase activity#GO:0016829;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 decarboxylase#PC00089 Coenzyme A biosynthesis#P02736>Pantothenate cysteine ligase#P02882;Coenzyme A biosynthesis#P02736>Pantothenoylcysteine decarboxylase#P02883 HELRO|EnsemblGenome=HelroG176861|UniProtKB=T1FAZ8 T1FAZ8 20205997 PTHR14596:SF72 ZINC FINGER PROTEIN ZINC FINGER PROTEIN MSN2-RELATED cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to nutrient levels#GO:0031667;response to extracellular stimulus#GO:0009991;response to stress#GO:0006950;response to starvation#GO:0042594 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG193605|UniProtKB=T1FV62 T1FV62 20212708 PTHR14309:SF10 EXPRESSED PROTEIN PH DOMAIN-CONTAINING PROTEIN biological regulation#GO:0065007;regulation of biological process#GO:0050789;regulation of cell differentiation#GO:0045595;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG103862|UniProtKB=T1EDI0 T1EDI0 20194632 PTHR24115:SF472 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF3A pyrophosphatase activity#GO:0016462;cytoskeletal protein binding#GO:0008092;microtubule motor activity#GO:0003777;tubulin binding#GO:0015631;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;cytoskeletal motor activity#GO:0003774;microtubule binding#GO:0008017;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;microtubule associated complex#GO:0005875;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG192784|UniProtKB=T1FUA4 T1FUA4 20212400 PTHR35193:SF5 MUCIN 13A, CELL SURFACE-ASSOCIATED-RELATED FLOCCULATION PROTEIN FLO11 HELRO|EnsemblGenome=HelroG166113|UniProtKB=T1EXS5 T1EXS5 20201375 PTHR47763:SF1 ALPHA-PROTEIN KINASE VWKA DUF659 DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-serine modification#GO:0018209;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG175544|UniProtKB=T1F9D3 T1F9D3 20205432 PTHR23507:SF1 ZGC:174356 FI18259P1-RELATED Endothelin signaling pathway#P00019>Adenylate cyclase#P00569 HELRO|EnsemblGenome=HelroG159054|UniProtKB=T1ENJ4 T1ENJ4 20198144 PTHR10075:SF100 BASIGIN RELATED FASCICLIN-2 cell adhesion molecule binding#GO:0050839;cell-cell adhesion mediator activity#GO:0098632;protein binding#GO:0005515;binding#GO:0005488 neuron projection guidance#GO:0097485;cell recognition#GO:0008037;neurogenesis#GO:0022008;cell projection organization#GO:0030030;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;axonogenesis#GO:0007409;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;homophilic cell adhesion via plasma membrane adhesion molecules#GO:0007156;cell-cell adhesion via plasma-membrane adhesion molecules#GO:0098742;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cell morphogenesis#GO:0000902;cellular process#GO:0009987;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure development#GO:0048856;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;axon#GO:0030424 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG105425|UniProtKB=T1EDU8 T1EDU8 20194750 PTHR10736:SF65 BESTROPHIN BESTROPHIN 1, ISOFORM C-RELATED inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;channel activity#GO:0015267 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG179728|UniProtKB=T1FF30 T1FF30 20207429 PTHR46480:SF1 F20B24.22 VOLTAGE-GATED HYDROGEN CHANNEL 1 monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;voltage-gated channel activity#GO:0022832;proton channel activity#GO:0015252;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;proton transmembrane transport#GO:1902600;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG153267|UniProtKB=T1EL23 T1EL23 20197273 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG81201|UniProtKB=T1G4B1 T1G4B1 20215909 PTHR18945:SF927 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-LIKE 1 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;localization#GO:0051179;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 membrane protein complex#GO:0098796;synapse#GO:0045202;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron projection#GO:0043005;transmembrane transporter complex#GO:1902495;cell projection#GO:0042995;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HELRO|EnsemblGenome=HelroG185887|UniProtKB=T1FNE5 T1FNE5 20210342 PTHR11830:SF0 40S RIBOSOMAL PROTEIN S3A SMALL RIBOSOMAL SUBUNIT PROTEIN ES1 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG184320|UniProtKB=T1FKZ6 T1FKZ6 20209495 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171280|UniProtKB=T1F411 T1F411 20203560 PTHR15073:SF16 MICROTUBULE-ASSOCIATED PROTEIN EGF-LIKE DOMAIN-CONTAINING PROTEIN cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG122766|UniProtKB=T1EGV7 T1EGV7 20195807 PTHR10828:SF76 M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25 M-PHASE INDUCER PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 regulation of cell cycle G2/M phase transition#GO:1902749;mitotic cell cycle phase transition#GO:0044772;regulation of mitotic cell cycle phase transition#GO:1901990;cell cycle process#GO:0022402;regulation of cell cycle phase transition#GO:1901987;positive regulation of cell cycle#GO:0045787;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047;cell cycle phase transition#GO:0044770;positive regulation of cellular process#GO:0048522;regulation of cell cycle process#GO:0010564;regulation of biological process#GO:0050789;G2/M transition of mitotic cell cycle#GO:0000086;mitotic cell cycle#GO:0000278;regulation of meiotic cell cycle#GO:0051445;regulation of cellular process#GO:0050794;positive regulation of cell cycle process#GO:0090068;positive regulation of mitotic cell cycle#GO:0045931;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of G2/M transition of mitotic cell cycle#GO:0010389;positive regulation of biological process#GO:0048518;regulation of mitotic cell cycle#GO:0007346;cell cycle G2/M phase transition#GO:0044839 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG122790|UniProtKB=T1EGV9 T1EGV9 20195809 PTHR10656:SF70 CELL FATE DETERMINING PROTEIN MAB21-RELATED PROTEIN MAB-21-RELATED transferase#PC00220;nucleotidyltransferase#PC00174;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG157491|UniProtKB=T1EMC2 T1EMC2 20197722 PTHR10024:SF227 SYNAPTOTAGMIN SYNAPTOTAGMIN 1 cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;phosphatidylserine binding#GO:0001786;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;protein binding#GO:0005515;clathrin binding#GO:0030276;lipid binding#GO:0008289;ion binding#GO:0043167;phospholipid binding#GO:0005543;SNARE binding#GO:0000149 cellular localization#GO:0051641;synaptic vesicle cycle#GO:0099504;synaptic vesicle endocytosis#GO:0048488;transport#GO:0006810;regulation of biological process#GO:0050789;regulated exocytosis#GO:0045055;synaptic vesicle recycling#GO:0036465;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;secretion#GO:0046903;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;signal release#GO:0023061;calcium-ion regulated exocytosis#GO:0017156;cell-cell signaling#GO:0007267;signaling#GO:0023052;synaptic vesicle exocytosis#GO:0016079;secretion by cell#GO:0032940;neurotransmitter secretion#GO:0007269;endocytosis#GO:0006897;trans-synaptic signaling#GO:0099537;vesicle-mediated transport#GO:0016192;cell communication#GO:0007154;cellular process#GO:0009987;localization#GO:0051179;signal release from synapse#GO:0099643;exocytosis#GO:0006887;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;import into cell#GO:0098657;export from cell#GO:0140352;vesicle-mediated transport in synapse#GO:0099003 intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;secretory vesicle#GO:0099503;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG116524|UniProtKB=T1EGF6 T1EGF6 20195658 PTHR45659:SF4 HOMEOBOX PROTEIN HOX HOMEOBOX PROTEIN ABDOMINAL-A sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regionalization#GO:0003002;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;anterior/posterior pattern specification#GO:0009952;multicellular organismal process#GO:0032501;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;pattern specification process#GO:0007389;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG158769|UniProtKB=T1EN88 T1EN88 20198038 PTHR10256:SF0 SELENIDE, WATER DIKINASE INACTIVE SELENIDE, WATER DIKINASE-LIKE PROTEIN-RELATED transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;proteinogenic amino acid biosynthetic process#GO:0170038;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;alpha-amino acid biosynthetic process#GO:1901607;nitrogen compound metabolic process#GO:0006807;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;small molecule biosynthetic process#GO:0044283;L-amino acid biosynthetic process#GO:0170034;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG72500|UniProtKB=T1G109 T1G109 20214757 PTHR10902:SF0 60S RIBOSOMAL PROTEIN L35A LARGE RIBOSOMAL SUBUNIT PROTEIN EL33 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG79073|UniProtKB=T1G3K0 T1G3K0 20215648 PTHR12442:SF5 DYNEIN INTERMEDIATE CHAIN DYNEIN AXONEMAL INTERMEDIATE CHAIN 3 protein binding#GO:0005515;binding#GO:0005488 cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;inner dynein arm assembly#GO:0036159;microtubule-based movement#GO:0007018;microtubule cytoskeleton organization#GO:0000226;cilium or flagellum-dependent cell motility#GO:0001539;protein-containing complex assembly#GO:0065003;cell motility#GO:0048870;cellular component organization#GO:0016043;axoneme assembly#GO:0035082;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;cilium movement involved in cell motility#GO:0060294;cilium movement#GO:0003341;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cilium-dependent cell motility#GO:0060285;microtubule-based process#GO:0007017;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection assembly#GO:0120031 axoneme#GO:0005930;inner dynein arm#GO:0036156;catalytic complex#GO:1902494;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;microtubule associated complex#GO:0005875;axonemal dynein complex#GO:0005858;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;ciliary plasm#GO:0097014;plasma membrane bounded cell projection cytoplasm#GO:0032838;membrane-bounded organelle#GO:0043227;dynein complex#GO:0030286;cell projection#GO:0042995;cytoskeleton#GO:0005856;cilium#GO:0005929 microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG164230|UniProtKB=T1EV50 T1EV50 20200450 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG189071|UniProtKB=T1FQM1 T1FQM1 20211118 PTHR21567:SF9 CLASP CLIP-ASSOCIATING PROTEIN cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule-based process#GO:0007017;organelle organization#GO:0006996 supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cytoplasmic microtubule#GO:0005881;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG170668|UniProtKB=T1F3A9 T1F3A9 20203308 PTHR12461:SF99 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG156575|UniProtKB=T1ELY6 T1ELY6 20197586 PTHR11021:SF1 SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;mRNA metabolic process#GO:0016071;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;ribosome biogenesis#GO:0042254;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;rRNA metabolic process#GO:0016072;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274 membrane-enclosed lumen#GO:0031974;supramolecular complex#GO:0099080;U6 snRNP#GO:0005688;organelle lumen#GO:0043233;nucleus#GO:0005634;P-body#GO:0000932;intracellular membrane-bounded organelle#GO:0043231;U4/U6 x U5 tri-snRNP complex#GO:0046540;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein complex#GO:1990904;ribonucleoprotein granule#GO:0035770;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;spliceosomal tri-snRNP complex#GO:0097526;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG165965|UniProtKB=T1EXI4 T1EXI4 20201284 PTHR33273:SF4 DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186290|UniProtKB=T1FNX6 T1FNX6 20210523 PTHR11955:SF135 FATTY ACID BINDING PROTEIN FATTY ACID BINDING PROTEIN, ISOFORM C fatty acid binding#GO:0005504;small molecule binding#GO:0036094;binding#GO:0005488;carboxylic acid binding#GO:0031406;lipid binding#GO:0008289;ion binding#GO:0043167;organic acid binding#GO:0043177;anion binding#GO:0043168 localization#GO:0051179;monocarboxylic acid transport#GO:0015718;organic substance transport#GO:0071702;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;organic anion transport#GO:0015711;fatty acid transport#GO:0015908;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;lipid localization#GO:0010876;lipid transport#GO:0006869 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG185575|UniProtKB=T1FMZ8 T1FMZ8 20210197 PTHR23420:SF0 ADENOSYLHOMOCYSTEINASE ADENOSYLHOMOCYSTEINASE hydrolase activity#GO:0016787;catalytic activity#GO:0003824 cellular metabolic process#GO:0044237;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG109225|UniProtKB=T1EER6 T1EER6 20195068 PTHR23235:SF156 KRUEPPEL-LIKE TRANSCRIPTION FACTOR KRUPPEL-LIKE FACTOR 18 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG157496|UniProtKB=T1EMC4 T1EMC4 20197724 PTHR43607:SF1 V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A H(+)-TRANSPORTING TWO-SECTOR ATPASE inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;proton transmembrane transporter activity#GO:0015078;active monoatomic ion transmembrane transporter activity#GO:0022853;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;proton transmembrane transport#GO:1902600;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG121109|UniProtKB=T1EGR0 T1EGR0 20195760 PTHR13906:SF4 PORCUPINE LYSOPHOSPHOLIPID ACYLTRANSFERASE 6 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;cellular metabolic process#GO:0044237;lipid modification#GO:0030258;cellular lipid metabolic process#GO:0044255;cellular process#GO:0009987;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transferase#PC00220;acetyltransferase#PC00038;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG158657|UniProtKB=T1EN35 T1EN35 20197985 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183927|UniProtKB=T1FKB1 T1FKB1 20209260 PTHR10649:SF12 ARYL HYDROCARBON RECEPTOR SPINELESS, ISOFORM C sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;molecular transducer activity#GO:0060089;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG63456|UniProtKB=T1FXG1 T1FXG1 20213509 PTHR13568:SF4 FAM11A, B PROTEIN TRANSMEMBRANE PROTEIN 60 HELRO|EnsemblGenome=HelroG170805|UniProtKB=T1F3G3 T1F3G3 20203362 PTHR24067:SF294 UBIQUITIN-CONJUGATING ENZYME E2 PROTEIN CROSSBRONX-RELATED ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG162999|UniProtKB=T1ETJ1 T1ETJ1 20199891 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG68394|UniProtKB=T1FZE0 T1FZE0 20214188 PTHR12786:SF2 SPLICING FACTOR SF3A-RELATED SPLICING FACTOR 3A SUBUNIT 3 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG185612|UniProtKB=T1FN14 T1FN14 20210213 PTHR44040:SF1 RETINOBLASTOMA-BINDING PROTEIN 5 RETINOBLASTOMA-BINDING PROTEIN 5 membrane-enclosed lumen#GO:0031974;histone methyltransferase complex#GO:0035097;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;methyltransferase complex#GO:0034708;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;Set1C/COMPASS complex#GO:0048188;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG177066|UniProtKB=T1FB70 T1FB70 20206069 PTHR10283:SF136 SOLUTE CARRIER FAMILY 13 MEMBER CITRATE TRANSPORTER-LIKE DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG192855|UniProtKB=T1FUD2 T1FUD2 20212428 PTHR12365:SF7 SPROUTY PROTEIN SPROUTY negative regulation of cellular metabolic process#GO:0031324;regulation of MAPK cascade#GO:0043408;negative regulation of biological process#GO:0048519;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of intracellular signal transduction#GO:1902532;animal organ development#GO:0048513;developmental process#GO:0032502;regulation of signaling#GO:0023051;regulation of catalytic activity#GO:0050790;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;negative regulation of protein phosphorylation#GO:0001933;negative regulation of protein modification process#GO:0031400;negative regulation of MAPK cascade#GO:0043409;regulation of molecular function#GO:0065009;regulation of signal transduction#GO:0009966;regulation of protein serine/threonine kinase activity#GO:0071900;regulation of cellular response to growth factor stimulus#GO:0090287;negative regulation of small GTPase mediated signal transduction#GO:0051058;negative regulation of protein kinase activity#GO:0006469;regulation of MAP kinase activity#GO:0043405;negative regulation of cellular process#GO:0048523;negative regulation of cell communication#GO:0010648;regulation of kinase activity#GO:0043549;regulation of protein kinase activity#GO:0045859;regulation of cell communication#GO:0010646;negative regulation of response to stimulus#GO:0048585;negative regulation of phosphorus metabolic process#GO:0010563;negative regulation of signaling#GO:0023057;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of response to stimulus#GO:0048583;regulation of primary metabolic process#GO:0080090;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of phosphorylation#GO:0042326;regulation of protein phosphorylation#GO:0001932;anatomical structure development#GO:0048856;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of phosphate metabolic process#GO:0045936;negative regulation of signal transduction#GO:0009968;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;negative regulation of catalytic activity#GO:0043086;regulation of metabolic process#GO:0019222;negative regulation of molecular function#GO:0044092;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 EGF receptor signaling pathway#P00018>Spry#P00541;EGF receptor signaling pathway#P00018>SPRY#G01511;FGF signaling pathway#P00021>Spry#P00626 HELRO|EnsemblGenome=HelroG184477|UniProtKB=T1FLA3 T1FLA3 20209602 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG187057|UniProtKB=T1FP64 T1FP64 20210611 PTHR13000:SF0 NUCLEOPORIN P54 NUCLEOPORIN P54 structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056 localization within membrane#GO:0051668;cellular localization#GO:0051641;NLS-bearing protein import into nucleus#GO:0006607;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;transport#GO:0006810;protein localization to nucleus#GO:0034504;nucleus organization#GO:0006997;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;cellular component organization#GO:0016043;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;protein import into nucleus#GO:0006606;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365;nuclear transport#GO:0051169;import into nucleus#GO:0051170 envelope#GO:0031975;nuclear pore#GO:0005643;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG96068|UniProtKB=T1G9A0 T1G9A0 20217647 PTHR10048:SF118 PHOSPHATIDYLINOSITOL KINASE PI-3 KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301;lipid kinase activity#GO:0001727 lipid metabolic process#GO:0006629;signal transduction#GO:0007165;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;glycerolipid metabolic process#GO:0046486;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular response to stimulus#GO:0051716;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;cell communication#GO:0007154;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;cell motility#GO:0048870;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0043491;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;glycerophospholipid biosynthetic process#GO:0046474;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;cell migration#GO:0016477 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;phosphatidylinositol 3-kinase complex#GO:0005942;catalytic complex#GO:1902494;transferase complex#GO:1990234;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;extrinsic component of membrane#GO:0019898 kinase#PC00137 PDGF signaling pathway#P00047>PI3K#P01168;Apoptosis signaling pathway#P00006>PI3K#P00310;Hypoxia response via HIF activation#P00030>PI3K#P00823;Axon guidance mediated by netrin#P00009>PI3K#P00363;PI3 kinase pathway#P00048>p110#P01192;EGF receptor signaling pathway#P00018>PI3K#P00557;VEGF signaling pathway#P00056>PI3K#P01413;FGF signaling pathway#P00021>PI3K#P00640;p53 pathway feedback loops 2#P04398>PI3K#P04661;Endothelin signaling pathway#P00019>PI3K#P00577;Integrin signalling pathway#P00034>PI3K#P00936;Angiogenesis#P00005>PI3K#P00236;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PI3K#P00868;Ras Pathway#P04393>PI3K#P04567;p53 pathway#P00059>PI3K#P04609;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PI3K#P00900;PI3 kinase pathway#P00048>P110ACT#P01177 HELRO|EnsemblGenome=HelroG157859|UniProtKB=T1EMH0 T1EMH0 20197770 PTHR24055:SF158 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE P38A-RELATED transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 TGF-beta signaling pathway#P00052>P38#P01275;Interferon-gamma signaling pathway#P00035>Serine kinase#P00955;EGF receptor signaling pathway#P00018>p38#P00562;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;p53 pathway feedback loops 2#P04398>p38 MAPK#P04648;Ras Pathway#P04393>p38#P04558;Parkinson disease#P00049>p38 MAPK#P01212;Oxidative stress response#P00046>p38#P01135;Parkinson disease#P00049>SAPK#P01219;FGF signaling pathway#P00021>p38#P00644 HELRO|EnsemblGenome=HelroG182318|UniProtKB=T1FI21 T1FI21 20208470 PTHR43250:SF2 EXODEOXYRIBONUCLEASE III EXODEOXYRIBONUCLEASE III HELRO|EnsemblGenome=HelroG142747|UniProtKB=T1EJ72 T1EJ72 20196622 PTHR19303:SF71 TRANSPOSON ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HELRO|EnsemblGenome=HelroG157357|UniProtKB=T1EMA2 T1EMA2 20197702 PTHR10871:SF3 30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18 SMALL RIBOSOMAL SUBUNIT PROTEIN US13 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;small ribosomal subunit#GO:0015935;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG117001|UniProtKB=T1EGJ2 T1EGJ2 20195694 PTHR18945:SF898 NEUROTRANSMITTER GATED ION CHANNEL GLUTAMATE-GATED CHLORIDE CHANNEL inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;chloride transmembrane transporter activity#GO:0015108;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;inorganic anion transmembrane transport#GO:0098661;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic anion transport#GO:0006820;chloride transport#GO:0006821;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;inorganic anion transport#GO:0015698 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG93125|UniProtKB=T1G8U0 T1G8U0 20217487 PTHR24390:SF244 ZINC FINGER PROTEIN LD33778P-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG155963|UniProtKB=T1ELP9 T1ELP9 20197499 PTHR13528:SF2 39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG80813|UniProtKB=T1G459 T1G459 20215857 PTHR23257:SF706 SERINE-THREONINE PROTEIN KINASE PROTO-ONCOGENE SERINE_THREONINE-PROTEIN KINASE MOS transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG90230|UniProtKB=T1G7M6 T1G7M6 20217073 PTHR23304:SF192 SPOT2-RELATED SYNTAXIN-BINDING PROTEIN 2 HELRO|EnsemblGenome=HelroG119038|UniProtKB=T1EGM2 T1EGM2 20195722 PTHR10037:SF288 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM SODIUM CHANNEL PROTEIN PARA monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;sodium channel activity#GO:0005272;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;inorganic cation transmembrane transporter activity#GO:0022890 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;membrane depolarization#GO:0051899;transport#GO:0006810;regulation of membrane potential#GO:0042391;system process#GO:0003008;action potential#GO:0001508;nervous system process#GO:0050877;cell communication#GO:0007154;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;sodium ion transport#GO:0006814;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;multicellular organismal process#GO:0032501;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 membrane protein complex#GO:0098796;sodium channel complex#GO:0034706;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG188181|UniProtKB=T1FPR0 T1FPR0 20210807 PTHR48162:SF4 YALI0A06930P G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG78404|UniProtKB=T1G3B4 T1G3B4 20215562 PTHR11178:SF1 IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL HELRO|EnsemblGenome=HelroG185398|UniProtKB=T1FMR6 T1FMR6 20210115 PTHR15592:SF18 MATRIN 3/NUCLEAR PROTEIN 220-RELATED SMOOTH, ISOFORM T nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nitrogen compound metabolic process#GO:0051171;regulation of biosynthetic process#GO:0009889;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG176885|UniProtKB=T1FB06 T1FB06 20206005 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192380|UniProtKB=T1FTV9 T1FTV9 20212256 PTHR22897:SF8 QUIESCIN Q6-RELATED SULFHYDRYL OXIDASE SULFHYDRYL OXIDASE protein-disulfide reductase activity#GO:0015035;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824;protein disulfide isomerase activity#GO:0003756;disulfide oxidoreductase activity#GO:0015036;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein folding#GO:0006457;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;extracellular region#GO:0005576;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxidase#PC00175;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG104323|UniProtKB=T1EDL0 T1EDL0 20194662 PTHR13532:SF3 FAMILY NOT NAMED INTEGRATOR COMPLEX SUBUNIT 14 HELRO|EnsemblGenome=HelroG186617|UniProtKB=T1FP17 T1FP17 20210564 PTHR24067:SF254 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2-17 KDA ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;macromolecule modification#GO:0043412;protein catabolic process#GO:0030163;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;nucleobase-containing compound metabolic process#GO:0006139;modification-dependent macromolecule catabolic process#GO:0043632;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;cellular response to stimulus#GO:0051716;protein ubiquitination#GO:0016567;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation or removal#GO:0070647;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E2#P01491 HELRO|EnsemblGenome=HelroG167348|UniProtKB=T1EZA3 T1EZA3 20201903 PTHR24543:SF325 MULTICOPPER OXIDASE-RELATED F5_8 TYPE C DOMAIN-CONTAINING PROTEIN oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG108190|UniProtKB=T1EEG6 T1EEG6 20194968 PTHR24056:SF233 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 9 cyclin-dependent protein kinase activity#GO:0097472;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG178952|UniProtKB=T1FDY2 T1FDY2 20207031 PTHR45986:SF1 ZINC FINGER MATRIN-TYPE PROTEIN 2 ZINC FINGER MATRIN-TYPE PROTEIN 2 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;spliceosomal tri-snRNP complex#GO:0097526;U4/U6 x U5 tri-snRNP complex#GO:0046540;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG183640|UniProtKB=T1FJZ1 T1FJZ1 20209140 PTHR21228:SF72 FAST LEU-RICH DOMAIN-CONTAINING LD32258P RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;regulation of mRNA stability#GO:0043488;regulation of mRNA catabolic process#GO:0061013;regulation of catabolic process#GO:0009894;regulation of nitrogen compound metabolic process#GO:0051171;RNA metabolic process#GO:0016070;mitochondrial gene expression#GO:0140053;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;regulation of biological quality#GO:0065008;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;mitochondrial RNA metabolic process#GO:0000959;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;regulation of cellular catabolic process#GO:0031329;regulation of RNA stability#GO:0043487;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;mitochondrial RNA processing#GO:0000963;primary metabolic process#GO:0044238;regulation of primary metabolic process#GO:0080090;nucleic acid metabolic process#GO:0090304;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;supramolecular complex#GO:0099080;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG188909|UniProtKB=T1FQG8 T1FQG8 20211065 PTHR14624:SF0 DFG10 PROTEIN POLYPRENOL REDUCTASE oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;macromolecule modification#GO:0043412;alcohol biosynthetic process#GO:0046165;protein modification process#GO:0036211;organic hydroxy compound biosynthetic process#GO:1901617;lipid catabolic process#GO:0016042;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;cellular lipid catabolic process#GO:0044242;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;organic hydroxy compound metabolic process#GO:1901615;isoprenoid catabolic process#GO:0008300;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein glycosylation#GO:0006486;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;alcohol metabolic process#GO:0006066;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;isoprenoid metabolic process#GO:0006720;primary metabolic process#GO:0044238;isoprenoid biosynthetic process#GO:0008299;carbohydrate derivative biosynthetic process#GO:1901137;small molecule catabolic process#GO:0044282;protein N-linked glycosylation#GO:0006487;small molecule biosynthetic process#GO:0044283;cellular lipid metabolic process#GO:0044255;glycosylation#GO:0070085;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG89783|UniProtKB=T1G7H6 T1G7H6 20217023 PTHR11909:SF155 CASEIN KINASE-RELATED GILGAMESH, ISOFORM L transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 signal transduction#GO:0007165;macromolecule modification#GO:0043412;transport#GO:0006810;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;endocytosis#GO:0006897;cellular metabolic process#GO:0044237;vesicle-mediated transport#GO:0016192;organonitrogen compound metabolic process#GO:1901564;protein phosphorylation#GO:0006468;cell communication#GO:0007154;cellular process#GO:0009987;primary metabolic process#GO:0044238;localization#GO:0051179;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;import into cell#GO:0098657 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Parkinson disease#P00049>Casein kinase I#P01242 HELRO|EnsemblGenome=HelroG174986|UniProtKB=T1F8P4 T1F8P4 20205193 PTHR46641:SF2 FMRFAMIDE RECEPTOR-RELATED FMRFAMIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG68267|UniProtKB=T1FZC3 T1FZC3 20214171 PTHR31547:SF1 MULTIVESICULAR BODY SUBUNIT 12B MULTIVESICULAR BODY SUBUNIT 12B regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;regulation of signaling#GO:0023051;biological regulation#GO:0065007;regulation of ERBB signaling pathway#GO:1901184 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;vesicle membrane#GO:0012506;organelle#GO:0043226;membrane#GO:0016020;endosome membrane#GO:0010008;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ESCRT I complex#GO:0000813;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770 HELRO|EnsemblGenome=HelroG192742|UniProtKB=T1FU91 T1FU91 20212387 PTHR23043:SF39 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA DYSFUSION, ISOFORM D sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG80450|UniProtKB=T1G408 T1G408 20215806 PTHR10574:SF365 NETRIN/LAMININ-RELATED NETRIN-A-RELATED neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;cell projection organization#GO:0030030;animal organ development#GO:0048513;developmental process#GO:0032502;dendrite development#GO:0016358;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;axonogenesis#GO:0007409;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization#GO:0016043;cell morphogenesis#GO:0000902;cellular process#GO:0009987;tissue development#GO:0009888;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;motor neuron axon guidance#GO:0008045;anatomical structure development#GO:0048856;animal organ morphogenesis#GO:0009887;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;collagen-containing extracellular matrix#GO:0062023;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;basement membrane#GO:0005604 extracellular matrix protein#PC00102 Axon guidance mediated by netrin#P00009>Netrin#P00357;Axon guidance mediated by Slit/Robo#P00008>Netrin#P00344 HELRO|EnsemblGenome=HelroG183893|UniProtKB=T1FKA6 T1FKA6 20209255 PTHR44307:SF2 PHOSPHOETHANOLAMINE METHYLTRANSFERASE PHOSPHOETHANOLAMINE METHYLTRANSFERASE ISOFORM X1 methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG185515|UniProtKB=T1FMX2 T1FMX2 20210171 PTHR14186:SF19 INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 7 regulation of response to stimulus#GO:0048583;biological regulation#GO:0065007;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;regulation of signaling#GO:0023051 HELRO|EnsemblGenome=HelroG90779|UniProtKB=T1G7W0 T1G7W0 20217157 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG180007|UniProtKB=T1FFC2 T1FFC2 20207521 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172144|UniProtKB=T1F524 T1F524 20203923 PTHR10915:SF1 SYNDECAN SYNDECAN cell motility#GO:0048870;cellular process#GO:0009987;cell migration#GO:0016477 cell surface#GO:0009986;cellular anatomical entity#GO:0110165 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG83724|UniProtKB=T1G596 T1G596 20216243 PTHR42985:SF2 SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER SODIUM-DEPENDENT MULTIVITAMIN TRANSPORTER symporter activity#GO:0015293;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;monoatomic cation transport#GO:0006812;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG64646|UniProtKB=T1FXX4 T1FXX4 20213672 PTHR12649:SF11 PEPTIDYL-TRNA HYDROLASE 2 PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL HELRO|EnsemblGenome=HelroG168079|UniProtKB=T1F052 T1F052 20202202 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165686|UniProtKB=T1EX62 T1EX62 20201162 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG177270|UniProtKB=T1FBF7 T1FBF7 20206156 PTHR28588:SF1 HAUS AUGMIN-LIKE COMPLEX SUBUNIT 5 HAUS AUGMIN-LIKE COMPLEX SUBUNIT 5 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cell cycle process#GO:0022402;centrosome cycle#GO:0007098;microtubule cytoskeleton organization#GO:0000226;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule organizing center organization#GO:0031023;chromosome segregation#GO:0007059;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;spindle assembly#GO:0051225;cell cycle#GO:0007049;cytoskeleton organization#GO:0007010;spindle organization#GO:0007051;non-membrane-bounded organelle assembly#GO:0140694 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;microtubule organizing center#GO:0005815;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;HAUS complex#GO:0070652;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;centrosome#GO:0005813;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG83313|UniProtKB=T1G540 T1G540 20216188 PTHR15241:SF386 TRANSFORMER-2-RELATED RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN-RELATED RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG163001|UniProtKB=T1ETJ3 T1ETJ3 20199893 PTHR31598:SF1 IQ DOMAIN-CONTAINING PROTEIN D DYNEIN REGULATORY COMPLEX PROTEIN 10 HELRO|EnsemblGenome=HelroG174618|UniProtKB=T1F8A9 T1F8A9 20205058 PTHR15341:SF3 SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;ribosome biogenesis#GO:0042254;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;maturation of 5.8S rRNA#GO:0000460;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;exosome (RNase complex)#GO:0000178 transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG184883|UniProtKB=T1FM47 T1FM47 20209896 PTHR11571:SF224 GLUTATHIONE S-TRANSFERASE HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE glutathione transferase activity#GO:0004364;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824 sulfur compound metabolic process#GO:0006790;nitrogen compound metabolic process#GO:0006807;peptide metabolic process#GO:0006518;cellular modified amino acid metabolic process#GO:0006575;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular process#GO:0009987;glutathione metabolic process#GO:0006749;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG173102|UniProtKB=T1F6C6 T1F6C6 20204375 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186145|UniProtKB=T1FNQ4 T1FNQ4 20210451 PTHR11774:SF4 GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA prenyltransferase activity#GO:0004659;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;protein modification process#GO:0036211;cellular process#GO:0009987;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234 acyltransferase#PC00042;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG185001|UniProtKB=T1FM93 T1FM93 20209942 PTHR30244:SF34 TRANSAMINASE DTDP-4-AMINO-4,6-DIDEOXYGALACTOSE TRANSAMINASE transferase activity#GO:0016740;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;transaminase activity#GO:0008483;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168 polysaccharide metabolic process#GO:0005976;carbohydrate biosynthetic process#GO:0016051;macromolecule biosynthetic process#GO:0009059;polysaccharide biosynthetic process#GO:0000271;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;carbohydrate metabolic process#GO:0005975;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238 transaminase#PC00216;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG176798|UniProtKB=T1FAX2 T1FAX2 20205971 PTHR14596:SF72 ZINC FINGER PROTEIN ZINC FINGER PROTEIN MSN2-RELATED cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to nutrient levels#GO:0031667;response to extracellular stimulus#GO:0009991;response to stress#GO:0006950;response to starvation#GO:0042594 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG157306|UniProtKB=T1EM92 T1EM92 20197692 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG188108|UniProtKB=T1FPN2 T1FPN2 20210779 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG119364|UniProtKB=T1EGN0 T1EGN0 20195730 PTHR10110:SF187 SODIUM/HYDROGEN EXCHANGER SODIUM_HYDROGEN EXCHANGER secondary active transmembrane transporter activity#GO:0015291;inorganic molecular entity transmembrane transporter activity#GO:0015318;antiporter activity#GO:0015297;transmembrane transporter activity#GO:0022857;potassium ion transmembrane transporter activity#GO:0015079;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;proton transmembrane transporter activity#GO:0015078;metal cation:proton antiporter activity#GO:0051139;active monoatomic ion transmembrane transporter activity#GO:0022853;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;inorganic cation transmembrane transporter activity#GO:0022890;transporter activity#GO:0005215 regulation of intracellular pH#GO:0051453;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;regulation of pH#GO:0006885;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;regulation of cellular pH#GO:0030641;import into cell#GO:0098657;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG175287|UniProtKB=T1F941 T1F941 20205340 PTHR46513:SF13 VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG78010|UniProtKB=T1G367 T1G367 20215515 PTHR45630:SF8 CATION-TRANSPORTING ATPASE-RELATED CATION-TRANSPORTING ATPASE transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;active monoatomic ion transmembrane transporter activity#GO:0022853;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation transmembrane transporter activity#GO:0008324 localization#GO:0051179;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG184944|UniProtKB=T1FM71 T1FM71 20209920 PTHR10551:SF9 FASCIN FASCIN-2 cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 establishment or maintenance of cell polarity#GO:0007163;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;actin filament bundle assembly#GO:0051017;cell motility#GO:0048870;cellular component organization#GO:0016043;actin filament bundle organization#GO:0061572;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cell migration#GO:0016477 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG160596|UniProtKB=T1EQG7 T1EQG7 20198817 PTHR11097:SF9 EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN EXOSOME COMPLEX COMPONENT RRP43 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159;mRNA 3'-UTR binding#GO:0003730 negative regulation of gene expression#GO:0010629;tRNA metabolic process#GO:0006399;cellular component biogenesis#GO:0044085;regulation of catabolic process#GO:0009894;heterocycle catabolic process#GO:0046700;regulation of nitrogen compound metabolic process#GO:0051171;rRNA processing#GO:0006364;positive regulation of cellular metabolic process#GO:0031325;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA destabilization#GO:0050779;modification-dependent macromolecule catabolic process#GO:0043632;regulation of biological process#GO:0050789;ncRNA metabolic process#GO:0034660;mRNA metabolic process#GO:0016071;regulation of biological quality#GO:0065008;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;snRNA 3'-end processing#GO:0034472;ribosome biogenesis#GO:0042254;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;cellular component organization or biogenesis#GO:0071840;positive regulation of mRNA catabolic process#GO:0061014;regulation of cellular process#GO:0050794;rRNA metabolic process#GO:0016072;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of catabolic process#GO:0009896;mRNA destabilization#GO:0061157;nucleobase-containing compound catabolic process#GO:0034655;polyadenylation-dependent ncRNA catabolic process#GO:0043634;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323;positive regulation of nitrogen compound metabolic process#GO:0051173;cellular aromatic compound metabolic process#GO:0006725;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;regulation of mRNA stability#GO:0043488;regulation of mRNA catabolic process#GO:0061013;RNA metabolic process#GO:0016070;positive regulation of cellular catabolic process#GO:0031331;RNA processing#GO:0006396;biosynthetic process#GO:0009058;cellular nitrogen compound catabolic process#GO:0044270;positive regulation of metabolic process#GO:0009893;organic cyclic compound metabolic process#GO:1901360;mRNA catabolic process#GO:0006402;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;snRNA processing#GO:0016180;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;organic substance catabolic process#GO:1901575;maturation of 5.8S rRNA#GO:0000460;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;positive regulation of mRNA metabolic process#GO:1903313;heterocycle metabolic process#GO:0046483;snRNA metabolic process#GO:0016073;macromolecule biosynthetic process#GO:0009059;negative regulation of biosynthetic process#GO:0009890;RNA 3'-end processing#GO:0031123;cellular biosynthetic process#GO:0044249;nuclear-transcribed mRNA catabolic process#GO:0000956;organic substance biosynthetic process#GO:1901576;regulation of cellular catabolic process#GO:0031329;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;regulation of cellular biosynthetic process#GO:0031326;aromatic compound catabolic process#GO:0019439;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;ribonucleoprotein complex biogenesis#GO:0022613;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;positive regulation of RNA metabolic process#GO:0051254 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513;exosome (RNase complex)#GO:0000178 RNA metabolism protein#PC00031;exoribonuclease#PC00099 HELRO|EnsemblGenome=HelroG165700|UniProtKB=T1EX67 T1EX67 20201167 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG79878|UniProtKB=T1G3U8 T1G3U8 20215746 PTHR10159:SF533 DUAL SPECIFICITY PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE VHP-1 hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 regulation of MAPK cascade#GO:0043408;negative regulation of biological process#GO:0048519;peptidyl-tyrosine dephosphorylation#GO:0035335;macromolecule modification#GO:0043412;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;protein modification process#GO:0036211;regulation of intracellular signal transduction#GO:1902531;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;negative regulation of MAPK cascade#GO:0043409;nitrogen compound metabolic process#GO:0006807;regulation of signal transduction#GO:0009966;protein metabolic process#GO:0019538;negative regulation of cellular process#GO:0048523;negative regulation of cell communication#GO:0010648;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;regulation of cell communication#GO:0010646;negative regulation of response to stimulus#GO:0048585;macromolecule metabolic process#GO:0043170;negative regulation of signaling#GO:0023057;cellular metabolic process#GO:0044237;protein dephosphorylation#GO:0006470;organonitrogen compound metabolic process#GO:1901564;cellular process#GO:0009987;primary metabolic process#GO:0044238;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;dephosphorylation#GO:0016311;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 Oxidative stress response#P00046>MKP5#P01131 HELRO|EnsemblGenome=HelroG81219|UniProtKB=T1G4B4 T1G4B4 20215912 PTHR46321:SF1 KIF1-BINDING PROTEIN KIF-BINDING PROTEIN HELRO|EnsemblGenome=HelroG194138|UniProtKB=T1FVQ9 T1FVQ9 20212905 PTHR10829:SF56 CORTACTIN AND DREBRIN ADF-H DOMAIN-CONTAINING PROTEIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 regulation of anatomical structure size#GO:0090066;regulation of actin filament length#GO:0030832;regulation of organelle organization#GO:0033043;regulation of actin filament organization#GO:0110053;regulation of cellular component organization#GO:0051128;cellular component organization#GO:0016043;regulation of actin polymerization or depolymerization#GO:0008064;cellular process#GO:0009987;regulation of actin filament polymerization#GO:0030833;regulation of cellular component size#GO:0032535;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cytoskeleton organization#GO:0051493;regulation of protein-containing complex assembly#GO:0043254;regulation of biological quality#GO:0065008;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament-based process#GO:0032970;regulation of protein polymerization#GO:0032271 supramolecular complex#GO:0099080;cortical cytoskeleton#GO:0030863;supramolecular polymer#GO:0099081;cellular anatomical entity#GO:0110165;cell cortex#GO:0005938;cell periphery#GO:0071944;supramolecular fiber#GO:0099512;cortical actin cytoskeleton#GO:0030864;organelle#GO:0043226;actin filament#GO:0005884;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;site of polarized growth#GO:0030427 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG185440|UniProtKB=T1FMT9 T1FMT9 20210138 PTHR12299:SF17 HYALURONIC ACID-BINDING PROTEIN 4 AT19571P-RELATED nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG90827|UniProtKB=T1G7W7 T1G7W7 20217164 PTHR24068:SF33 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2Q 2 ISOFORM 1 ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG85645|UniProtKB=T1G610 T1G610 20216507 PTHR24299:SF21 CYTOCHROME P450 FAMILY 1 OS09G0441600 PROTEIN oxygenase#PC00177;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG95474|UniProtKB=T1G961 T1G961 20217608 PTHR12480:SF6 ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD 2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE JMJD4 sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;dioxygenase activity#GO:0051213;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491 positive regulation of gene expression#GO:0010628;positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;macromolecule modification#GO:0043412;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;protein modification process#GO:0036211;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;protein hydroxylation#GO:0018126;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;protein metabolic process#GO:0019538;positive regulation of biological process#GO:0048518;positive regulation of translation#GO:0045727;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;regulation of protein-containing complex disassembly#GO:0043244;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;primary metabolic process#GO:0044238;regulation of primary metabolic process#GO:0080090;positive regulation of protein metabolic process#GO:0051247;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;regulation of translation#GO:0006417;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG177743|UniProtKB=T1FC63 T1FC63 20206412 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG111546|UniProtKB=T1EFC3 T1EFC3 20195275 PTHR10514:SF27 ANGIOTENSIN-CONVERTING ENZYME ANGIOTENSIN-CONVERTING ENZYME metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG155500|UniProtKB=T1ELI6 T1ELI6 20197436 PTHR18945:SF865 NEUROTRANSMITTER GATED ION CHANNEL NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA7, ISOFORM E ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG170902|UniProtKB=T1F3K7 T1F3K7 20203406 PTHR25462:SF291 BONUS, ISOFORM C-RELATED E3 UBIQUITIN-PROTEIN LIGASE TRIM45 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG89932|UniProtKB=T1G7J2 T1G7J2 20217039 PTHR17600:SF2 MESODERM DEVELOPMENT CANDIDATE 2 LRP CHAPERONE MESD HELRO|EnsemblGenome=HelroG160514|UniProtKB=T1EQC5 T1EQC5 20198775 PTHR15683:SF8 SCAFFOLD ATTACHMENT FACTOR B-RELATED SCAFFOLD ATTACHMENT FACTOR B, ISOFORM B sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of mRNA processing#GO:0050684;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;regulation of mRNA metabolic process#GO:1903311 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG139427|UniProtKB=T1EIY7 T1EIY7 20196537 PTHR10082:SF60 INTEGRIN BETA SUBUNIT INTEGRIN BETA-PS cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;integrin binding#GO:0005178;binding#GO:0005488;signaling receptor binding#GO:0005102 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;cell adhesion mediated by integrin#GO:0033627;cell-cell adhesion#GO:0098609;cell motility#GO:0048870;cell adhesion#GO:0007155;cell communication#GO:0007154;cell-substrate adhesion#GO:0031589;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cell-matrix adhesion#GO:0007160;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;integrin-mediated signaling pathway#GO:0007229;cell migration#GO:0016477;signaling#GO:0023052 receptor complex#GO:0043235;membrane protein complex#GO:0098796;cell surface#GO:0009986;protein-containing complex#GO:0032991;plasma membrane signaling receptor complex#GO:0098802;anchoring junction#GO:0070161;plasma membrane protein complex#GO:0098797;focal adhesion#GO:0005925;cell junction#GO:0030054;cell-substrate junction#GO:0030055;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;integrin#PC00126 Integrin signalling pathway#P00034>Integrin beta#P00931 HELRO|EnsemblGenome=HelroG73944|UniProtKB=T1G1K5 T1G1K5 20214953 PTHR11003:SF334 POTASSIUM CHANNEL, SUBFAMILY K FI03418P monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG123629|UniProtKB=T1EGY3 T1EGY3 20195833 PTHR45939:SF5 PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED PEROXISOMAL MEMBRANE PROTEIN PMP34 carbohydrate derivative transmembrane transporter activity#GO:1901505;purine nucleotide transmembrane transporter activity#GO:0015216;nucleobase-containing compound transmembrane transporter activity#GO:0015932;transmembrane transporter activity#GO:0022857;organic anion transmembrane transporter activity#GO:0008514;organic cation transmembrane transporter activity#GO:0015101;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;transport#GO:0006810 peroxisomal membrane#GO:0005778;cytoplasm#GO:0005737;bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;microbody#GO:0042579;peroxisome#GO:0005777;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG102838|UniProtKB=T1EDC2 T1EDC2 20194574 PTHR10782:SF94 ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN SUPPRESSOR OF VARIEGATION 2-10, ISOFORM I molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;SUMO transferase activity#GO:0019789;protein-macromolecule adaptor activity#GO:0030674;ubiquitin-like protein ligase activity#GO:0061659;SUMO ligase activity#GO:0061665;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;regulation of DNA-templated transcription#GO:0006355;macromolecule metabolic process#GO:0043170;regulation of nitrogen compound metabolic process#GO:0051171;protein sumoylation#GO:0016925;regulation of transcription by RNA polymerase II#GO:0006357;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;regulation of RNA biosynthetic process#GO:2001141;post-translational protein modification#GO:0043687;regulation of RNA metabolic process#GO:0051252;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Interferon-gamma signaling pathway#P00035>PIAS#P00958 HELRO|EnsemblGenome=HelroG67684|UniProtKB=T1FZ39 T1FZ39 20214087 PTHR15710:SF160 E3 UBIQUITIN-PROTEIN LIGASE PRAJA E3 UBIQUITIN-PROTEIN LIGASE RNF181 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG177964|UniProtKB=T1FCJ0 T1FCJ0 20206539 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG174084|UniProtKB=T1F7L0 T1F7L0 20204809 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG191003|UniProtKB=T1FSH6 T1FSH6 20211773 PTHR31703:SF2 UPF0669 PROTEIN C6ORF120 UPF0669 PROTEIN C6ORF120 HELRO|EnsemblGenome=HelroG103307|UniProtKB=T1EDF5 T1EDF5 20194607 PTHR48092:SF26 KNIRPS-RELATED PROTEIN-RELATED NR LBD DOMAIN-CONTAINING PROTEIN cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;signaling receptor activity#GO:0038023;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG179517|UniProtKB=T1FEU0 T1FEU0 20207339 PTHR36191:SF1 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG87471|UniProtKB=T1G6Q5 T1G6Q5 20216752 PTHR11850:SF108 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS HOMEOBOX PROTEIN EXTRADENTICLE cellular developmental process#GO:0048869;neurogenesis#GO:0022008;animal organ development#GO:0048513;multicellular organism development#GO:0007275;developmental process#GO:0032502;cellular process#GO:0009987;nervous system development#GO:0007399;cell development#GO:0048468;system development#GO:0048731;embryonic organ development#GO:0048568;cell differentiation#GO:0030154;embryo development#GO:0009790;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;neuron differentiation#GO:0030182;animal organ morphogenesis#GO:0009887;neuron development#GO:0048666;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG169160|UniProtKB=T1F1I1 T1F1I1 20202681 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175974|UniProtKB=T1F9Z5 T1F9Z5 20205644 PTHR20956:SF12 HEH2P FLYWCH-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194532|UniProtKB=T1FW59 T1FW59 20213055 PTHR25462:SF305 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG172219|UniProtKB=T1F555 T1F555 20203954 PTHR14596:SF72 ZINC FINGER PROTEIN ZINC FINGER PROTEIN MSN2-RELATED cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to nutrient levels#GO:0031667;response to extracellular stimulus#GO:0009991;response to stress#GO:0006950;response to starvation#GO:0042594 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG191173|UniProtKB=T1FSP6 T1FSP6 20211843 PTHR15036:SF85 PIKACHURIN-LIKE PROTEIN SP2353, ISOFORM A cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG109594|UniProtKB=T1EEV1 T1EEV1 20195103 PTHR24115:SF1004 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF15 pyrophosphatase activity#GO:0016462;cytoskeletal protein binding#GO:0008092;microtubule motor activity#GO:0003777;tubulin binding#GO:0015631;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;cytoskeletal motor activity#GO:0003774;microtubule binding#GO:0008017;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;microtubule associated complex#GO:0005875;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG181207|UniProtKB=T1FGQ7 T1FGQ7 20208006 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185731|UniProtKB=T1FN77 T1FN77 20210275 PTHR11615:SF6 NITRATE, FORMATE, IRON DEHYDROGENASE NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG68122|UniProtKB=T1FZA5 T1FZA5 20214153 PTHR45798:SF97 RING-H2 FINGER PROTEIN ATL61-RELATED-RELATED ALCOHOL-SENSITIVE RING FINGER PROTEIN 1 HELRO|EnsemblGenome=HelroG76296|UniProtKB=T1G2I0 T1G2I0 20215278 PTHR10048:SF22 PHOSPHATIDYLINOSITOL KINASE PHOSPHATIDYLINOSITOL 4-KINASE BETA transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301;lipid kinase activity#GO:0001727 lipid metabolic process#GO:0006629;signal transduction#GO:0007165;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;glycerolipid metabolic process#GO:0046486;intracellular signal transduction#GO:0035556;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular response to stimulus#GO:0051716;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;cell communication#GO:0007154;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;glycerophospholipid biosynthetic process#GO:0046474;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 kinase#PC00137 HELRO|EnsemblGenome=HelroG108097|UniProtKB=T1EEF4 T1EEF4 20194956 PTHR21351:SF0 BARDET-BIEDL SYNDROME PROTEIN 5 BARDET-BIEDL SYNDROME 5 PROTEIN phosphatidylinositol-3-phosphate binding#GO:0032266;lipid binding#GO:0008289;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981;binding#GO:0005488 cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;cilium assembly#GO:0060271;cell projection organization#GO:0030030;transport#GO:0006810;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;localization#GO:0051179;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;plasma membrane bounded cell projection assembly#GO:0120031 microtubule organizing center#GO:0005815;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;BBSome#GO:0034464;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG188572|UniProtKB=T1FQ50 T1FQ50 20210947 PTHR24023:SF1095 COLLAGEN ALPHA EGF-LIKE DOMAIN-CONTAINING PROTEIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Integrin alpha#P00941;Integrin signalling pathway#P00034>Collagen#P00922 HELRO|EnsemblGenome=HelroG105390|UniProtKB=T1EDU3 T1EDU3 20194745 PTHR12537:SF12 RNA BINDING PROTEIN PUMILIO-RELATED MATERNAL PROTEIN PUMILIO nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG190297|UniProtKB=T1FRV6 T1FRV6 20211553 PTHR46896:SF3 SENTRIN-SPECIFIC PROTEASE FI06413P-RELATED cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG105287|UniProtKB=T1EDT1 T1EDT1 20194733 PTHR45746:SF6 LP21163P LP21163P nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of cell communication#GO:0010646;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;regulation of signaling#GO:0023051;positive regulation of molecular function#GO:0044093;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;regulation of molecular function#GO:0065009;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731 HELRO|EnsemblGenome=HelroG116356|UniProtKB=T1EGE2 T1EGE2 20195644 PTHR23226:SF416 ZINC FINGER AND SCAN DOMAIN-CONTAINING FI01424P C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG187537|UniProtKB=T1FPA5 T1FPA5 20210652 PTHR43658:SF8 SHORT-CHAIN DEHYDROGENASE/REDUCTASE 17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG190267|UniProtKB=T1FRU2 T1FRU2 20211539 PTHR22957:SF661 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN GH16847P nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;activation of GTPase activity#GO:0090630;biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG169150|UniProtKB=T1F1H2 T1F1H2 20202672 PTHR36191:SF1 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG68015|UniProtKB=T1FZ92 T1FZ92 20214140 PTHR13385:SF0 AUTOPHAGY PROTEIN 12 UBIQUITIN-LIKE PROTEIN ATG12 ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824 microautophagy#GO:0016237;cellular component biogenesis#GO:0044085;macroautophagy#GO:0016236;macromolecule modification#GO:0043412;protein modification process#GO:0036211;autophagy of mitochondrion#GO:0000422;biosynthetic process#GO:0009058;post-translational protein modification#GO:0043687;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;cellular component disassembly#GO:0022411;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;mitochondrion organization#GO:0007005;autophagosome maturation#GO:0097352;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;protein-containing complex disassembly#GO:0032984;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular component organization#GO:0016043;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organelle disassembly#GO:1903008;lipoprotein biosynthetic process#GO:0042158;primary metabolic process#GO:0044238;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;autophagosome assembly#GO:0000045;lipoprotein metabolic process#GO:0042157;piecemeal microautophagy of the nucleus#GO:0034727;autophagy#GO:0006914 bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;vacuolar membrane#GO:0005774;vacuole#GO:0005773;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;autophagosome#GO:0005776;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;autophagosome membrane#GO:0000421;protein-containing complex#GO:0032991;phagophore assembly site#GO:0000407;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG72282|UniProtKB=T1G0Y0 T1G0Y0 20214728 PTHR24637:SF377 COLLAGEN COLLAGEN TYPE IX ALPHA 1 CHAIN HELRO|EnsemblGenome=HelroG106331|UniProtKB=T1EE21 T1EE21 20194823 PTHR24390:SF242 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 76 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG103469|UniProtKB=T1EDG3 T1EDG3 20194615 PTHR12203:SF35 KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED PROTEIN O-GLUCOSYLTRANSFERASE 1 HELRO|EnsemblGenome=HelroG188595|UniProtKB=T1FQ56 T1FQ56 20210953 PTHR10337:SF6 SHC TRANSFORMING PROTEIN CENTROSOMAL PROTEIN OF 152 KDA scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG179157|UniProtKB=T1FEA0 T1FEA0 20207149 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG103959|UniProtKB=T1EDI8 T1EDI8 20194640 PTHR11035:SF35 VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;monocarboxylic acid biosynthetic process#GO:0072330;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;organic acid metabolic process#GO:0006082;membrane lipid biosynthetic process#GO:0046467;sphingolipid metabolic process#GO:0006665;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;fatty acid metabolic process#GO:0006631;membrane lipid metabolic process#GO:0006643;nitrogen compound metabolic process#GO:0006807;small molecule biosynthetic process#GO:0044283;cellular lipid metabolic process#GO:0044255;carboxylic acid metabolic process#GO:0019752;sphingolipid biosynthetic process#GO:0030148;fatty acid biosynthetic process#GO:0006633;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG66647|UniProtKB=T1FYN5 T1FYN5 20213933 PTHR11686:SF9 GAMMA GLUTAMYL TRANSPEPTIDASE RE13973P hydrolase activity#GO:0016787;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 sulfur compound metabolic process#GO:0006790;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;peptide catabolic process#GO:0043171;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;cellular process#GO:0009987;glutathione metabolic process#GO:0006749;sulfur compound catabolic process#GO:0044273;nitrogen compound metabolic process#GO:0006807;cellular modified amino acid metabolic process#GO:0006575;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG193653|UniProtKB=T1FV82 T1FV82 20212728 PTHR45710:SF26 C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 180 RH26557P defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG157435|UniProtKB=T1EMB4 T1EMB4 20197714 PTHR10466:SF0 PHOSPHOMANNOMUTASE PHOSPHOMANNOMUTASE isomerase activity#GO:0016853;intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;monosaccharide metabolic process#GO:0005996;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;hexose metabolic process#GO:0019318;protein metabolic process#GO:0019538;carbohydrate metabolic process#GO:0005975;glycoprotein metabolic process#GO:0009100;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 mutase#PC00160 Mannose metabolism#P02752>P-Mannose mutase#P03019 HELRO|EnsemblGenome=HelroG190508|UniProtKB=T1FS21 T1FS21 20211618 PTHR48162:SF4 YALI0A06930P G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG121655|UniProtKB=T1EGS6 T1EGS6 20195776 PTHR12428:SF66 OXA1 MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L localization within membrane#GO:0051668;cellular localization#GO:0051641;macromolecule localization#GO:0033036;membrane organization#GO:0061024;protein localization to membrane#GO:0072657;establishment of protein localization to organelle#GO:0072594;cellular component organization#GO:0016043;protein localization to mitochondrion#GO:0070585;cellular process#GO:0009987;establishment of protein localization#GO:0045184;inner mitochondrial membrane organization#GO:0007007;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to membrane#GO:0090150;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;establishment of protein localization to mitochondrion#GO:0072655;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;protein localization to organelle#GO:0033365;mitochondrion organization#GO:0007005;mitochondrial membrane organization#GO:0007006;protein insertion into membrane#GO:0051205 envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;organelle inner membrane#GO:0019866;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227 transporter#PC00227 HELRO|EnsemblGenome=HelroG97481|UniProtKB=T1G9H0 T1G9H0 20217717 PTHR23065:SF11 PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1 SYNDAPIN, ISOFORM C lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488 regulation of endocytosis#GO:0030100;membrane organization#GO:0061024;plasma membrane organization#GO:0007009;endomembrane system organization#GO:0010256;regulation of localization#GO:0032879;regulation of cellular component organization#GO:0051128;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of transport#GO:0051049;regulation of cellular process#GO:0050794;organelle organization#GO:0006996;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG130916|UniProtKB=T1EHU7 T1EHU7 20196147 PTHR12172:SF0 CELL CYCLE CHECKPOINT PROTEIN RAD17 CELL CYCLE CHECKPOINT PROTEIN RAD17 ATP-dependent activity, acting on DNA#GO:0008094;ATP-dependent activity#GO:0140657;chromatin binding#GO:0003682;binding#GO:0005488;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on DNA#GO:0140097;protein-containing complex binding#GO:0044877 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;negative regulation of biological process#GO:0048519;signal transduction#GO:0007165;DNA damage checkpoint signaling#GO:0000077;mitotic cell cycle checkpoint signaling#GO:0007093;cell cycle process#GO:0022402;negative regulation of cell cycle process#GO:0010948;nucleobase-containing compound metabolic process#GO:0006139;mitotic cell cycle process#GO:1903047;regulation of biological process#GO:0050789;cell cycle checkpoint signaling#GO:0000075;negative regulation of mitotic cell cycle phase transition#GO:1901991;DNA damage response#GO:0006974;mitotic cell cycle#GO:0000278;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;signal transduction in response to DNA damage#GO:0042770;mitotic DNA replication checkpoint signaling#GO:0033314;intracellular signal transduction#GO:0035556;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;regulation of cell cycle G2/M phase transition#GO:1902749;negative regulation of cell cycle G2/M phase transition#GO:1902750;regulation of mitotic cell cycle phase transition#GO:1901990;macromolecule metabolic process#GO:0043170;negative regulation of cell cycle#GO:0045786;regulation of cell cycle phase transition#GO:1901987;negative regulation of cell cycle phase transition#GO:1901988;cellular metabolic process#GO:0044237;cell communication#GO:0007154;negative regulation of mitotic cell cycle#GO:0045930;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;regulation of cell cycle process#GO:0010564;response to stimulus#GO:0050896;DNA integrity checkpoint signaling#GO:0031570;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;DNA replication checkpoint signaling#GO:0000076;regulation of cellular process#GO:0050794;mitotic G2/M transition checkpoint#GO:0044818;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of G2/M transition of mitotic cell cycle#GO:0010389;mitotic DNA integrity checkpoint signaling#GO:0044774;cellular response to stress#GO:0033554;regulation of mitotic cell cycle#GO:0007346;DNA metabolic process#GO:0006259 HELRO|EnsemblGenome=HelroG165838|UniProtKB=T1EXC5 T1EXC5 20201225 PTHR12692:SF0 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED GH11935P glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;protein metabolic process#GO:0019538;protein N-linked glycosylation via asparagine#GO:0018279;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 membrane protein complex#GO:0098796;endoplasmic reticulum protein-containing complex#GO:0140534;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;oligosaccharyltransferase complex#GO:0008250;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG182602|UniProtKB=T1FIG3 T1FIG3 20208612 PTHR42264:SF3 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN F-BOX DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG161833|UniProtKB=T1ERY6 T1ERY6 20199336 PTHR33150:SF1 EXTRACELLULAR MATRIX-BINDING PROTEIN EBH EXTRACELLULAR MATRIX-BINDING PROTEIN EBH HELRO|EnsemblGenome=HelroG176792|UniProtKB=T1FAX1 T1FAX1 20205970 PTHR22545:SF0 CENTROSOMAL PROTEIN OF 95 KDA CENTROSOMAL PROTEIN OF 95 KDA intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;spindle pole#GO:0000922;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;spindle#GO:0005819;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG174434|UniProtKB=T1F844 T1F844 20204993 PTHR11818:SF42 BETA/GAMMA CRYSTALLIN VOLTAGE-GATED HYDROGEN CHANNEL 1 structural protein#PC00211 HELRO|EnsemblGenome=HelroG178284|UniProtKB=T1FD12 T1FD12 20206711 PTHR24173:SF83 ANKYRIN REPEAT CONTAINING SOCS BOX DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG178752|UniProtKB=T1FDN8 T1FDN8 20206937 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167440|UniProtKB=T1EZD8 T1EZD8 20201938 PTHR22605:SF16 RZ-TYPE DOMAIN-CONTAINING PROTEIN E3 UBIQUITIN-PROTEIN LIGASE RNF213 HELRO|EnsemblGenome=HelroG167613|UniProtKB=T1EZK2 T1EZK2 20202002 PTHR32026:SF10 METHYLTRANSFERASE-LIKE PROTEIN 24 METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG188155|UniProtKB=T1FPP9 T1FPP9 20210796 PTHR45828:SF42 CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE DEFENSE PROTEIN L(2)34FC cellular anatomical entity#GO:0110165;membrane#GO:0016020 reductase#PC00198;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG70686|UniProtKB=T1G0A6 T1G0A6 20214504 PTHR43028:SF5 3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1 3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1 hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG153266|UniProtKB=T1EL22 T1EL22 20197272 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG89720|UniProtKB=T1G7G5 T1G7G5 20217012 PTHR13723:SF200 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE ADAM METALLOPEPTIDASE WITH THROMBOSPONDIN TYPE 1 MOTIF B, ISOFORM B hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;cellular component organization#GO:0016043;cellular process#GO:0009987;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG190105|UniProtKB=T1FRP5 T1FRP5 20211492 PTHR43785:SF14 GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE GLUTAMINE SYNTHETASE metabolite interconversion enzyme#PC00262;ligase#PC00142 HELRO|EnsemblGenome=HelroG165175|UniProtKB=T1EWD7 T1EWD7 20200887 PTHR45982:SF1 REGULATOR OF CHROMOSOME CONDENSATION REGULATOR OF CHROMOSOME CONDENSATION HELRO|EnsemblGenome=HelroG190655|UniProtKB=T1FS62 T1FS62 20211659 PTHR22692:SF33 MYOSIN VII, XV MYOSIN actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG102358|UniProtKB=T1ED96 T1ED96 20194548 PTHR19865:SF0 U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2 U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2 snoRNA binding#GO:0030515;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 small-subunit processome#GO:0032040;ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG71670|UniProtKB=T1G0P9 T1G0P9 20214647 PTHR23404:SF2 MOLYBDOPTERIN SYNTHASE RELATED MOLYBDOPTERIN SYNTHASE CATALYTIC SUBUNIT cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG62052|UniProtKB=T1FWU8 T1FWU8 20213296 PTHR13563:SF13 TRNA (GUANINE-9-) METHYLTRANSFERASE TRNA METHYLTRANSFERASE 10 HOMOLOG A RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG185664|UniProtKB=T1FN41 T1FN41 20210239 PTHR12758:SF19 APOPTOSIS INHIBITOR 5-RELATED APOPTOSIS INHIBITOR 5 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG182973|UniProtKB=T1FJ08 T1FJ08 20208807 PTHR13297:SF9 TBC1 DOMAIN FAMILY MEMBER 23-RELATED ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG160670|UniProtKB=T1EQL0 T1EQL0 20198860 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG88841|UniProtKB=T1G770 T1G770 20216917 PTHR24416:SF580 TYROSINE-PROTEIN KINASE RECEPTOR DISCOIDIN DOMAIN RECEPTOR, ISOFORM F signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888;transferase activity#GO:0016740;transmembrane receptor protein kinase activity#GO:0019199;collagen binding#GO:0005518;molecular transducer activity#GO:0060089;protein-containing complex binding#GO:0044877;catalytic activity, acting on a protein#GO:0140096 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;regulation of cellular component organization#GO:0051128;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;regulation of plasma membrane bounded cell projection organization#GO:0120035;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;regulation of neuron projection development#GO:0010975;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;anatomical structure development#GO:0048856;regulation of cell projection organization#GO:0031344;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG153320|UniProtKB=T1EL37 T1EL37 20197287 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG188516|UniProtKB=T1FQ30 T1FQ30 20210927 PTHR11267:SF204 T-BOX PROTEIN-RELATED SPADETAIL sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cell fate commitment#GO:0045165;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;cell fate specification#GO:0001708;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HELRO|EnsemblGenome=HelroG110634|UniProtKB=T1EF37 T1EF37 20195189 PTHR42923:SF3 PROTOPORPHYRINOGEN OXIDASE PROTOPORPHYRINOGEN OXIDASE oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 oxidase#PC00175;oxidoreductase#PC00176 Heme biosynthesis#P02746>Protoporphyrinogen oxidase#P02976 HELRO|EnsemblGenome=HelroG158471|UniProtKB=T1EMU1 T1EMU1 20197891 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180594|UniProtKB=T1FG28 T1FG28 20207777 PTHR13099:SF0 NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B14.5B NADH DEHYDROGENASE [UBIQUINONE] 1 SUBUNIT C2-RELATED envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transporter complex#GO:1990351;oxidoreductase complex#GO:1990204;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;respirasome#GO:0070469;mitochondrial respiratory chain complex I#GO:0005747;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;transmembrane transporter complex#GO:1902495;mitochondrial respirasome#GO:0005746;membrane-bounded organelle#GO:0043227;respiratory chain complex I#GO:0045271;NADH dehydrogenase complex#GO:0030964;mitochondrial protein-containing complex#GO:0098798 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG68977|UniProtKB=T1FZM9 T1FZM9 20214277 PTHR46473:SF26 GH08155P LRRNT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG74602|UniProtKB=T1G1T3 T1G1T3 20215031 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG162420|UniProtKB=T1ESM6 T1ESM6 20199576 PTHR12318:SF0 TESTOSTERONE-REGULATED PROTEIN RP2 ACYL-COENZYME A DIPHOSPHATASE NUDT19 HELRO|EnsemblGenome=HelroG174143|UniProtKB=T1F7P3 T1F7P3 20204842 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177528|UniProtKB=T1FBU5 T1FBU5 20206294 PTHR23227:SF85 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2 HELRO|EnsemblGenome=HelroG167481|UniProtKB=T1EZF0 T1EZF0 20201950 PTHR14454:SF11 GRB2-ASSOCIATED AND REGULATOR OF MAPK PROTEIN FAMILY MEMBER SERRANO, ISOFORM F HELRO|EnsemblGenome=HelroG168693|UniProtKB=T1F0V3 T1F0V3 20202453 PTHR42264:SF3 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN F-BOX DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG177728|UniProtKB=T1FC52 T1FC52 20206401 PTHR11559:SF370 CARBOXYLESTERASE ACETYLCHOLINESTERASE esterase#PC00097;hydrolase#PC00121 Nicotinic acetylcholine receptor signaling pathway#P00044>AChE#P01093;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>AChE#P01067;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>AChE#P01080 HELRO|EnsemblGenome=HelroG180130|UniProtKB=T1FFI1 T1FFI1 20207580 PTHR43404:SF1 LIPOPOLYSACCHARIDE CHOLINEPHOSPHOTRANSFERASE LICD MNN4P transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG74642|UniProtKB=T1G1T5 T1G1T5 20215033 PTHR24637:SF377 COLLAGEN COLLAGEN TYPE IX ALPHA 1 CHAIN HELRO|EnsemblGenome=HelroG183559|UniProtKB=T1FJU6 T1FJU6 20209095 PTHR23004:SF23 DOUBLECORTIN DOMAIN CONTAINING 2 DOUBLECORTIN DOMAIN-CONTAINING PROTEIN supramolecular complex#GO:0099080;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG191734|UniProtKB=T1FT88 T1FT88 20212035 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175137|UniProtKB=T1F8W9 T1F8W9 20205268 PTHR10985:SF77 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED GH26014P sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of multicellular organismal process#GO:0051239;regulation of cell development#GO:0060284;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regionalization#GO:0003002;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of RNA biosynthetic process#GO:2001141;regulation of multicellular organismal development#GO:2000026;regulation of cell differentiation#GO:0045595;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of neurogenesis#GO:0050767;regulation of macromolecule metabolic process#GO:0060255;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;regulation of nervous system development#GO:0051960;biological regulation#GO:0065007;anterior/posterior pattern specification#GO:0009952;multicellular organismal process#GO:0032501;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;pattern specification process#GO:0007389;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG76166|UniProtKB=T1G2G0 T1G2G0 20215258 PTHR10155:SF10 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT PI3K21B, ISOFORM B enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;phosphatidylinositol 3-kinase complex#GO:0005942;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;membrane#GO:0016020;transferase complex, transferring phosphorus-containing groups#GO:0061695;extrinsic component of membrane#GO:0019898 kinase modulator#PC00140 p53 pathway feedback loops 2#P04398>PI3K#P04661;p53 pathway#P00059>PI3K#P04609;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PI3K#P00900;Endothelin signaling pathway#P00019>PI3K#P00577;Angiogenesis#P00005>PI3K#P00236;Integrin signalling pathway#P00034>PI3K#P00936;VEGF signaling pathway#P00056>PI3K#P01413 HELRO|EnsemblGenome=HelroG159202|UniProtKB=T1ENQ8 T1ENQ8 20198208 PTHR13063:SF10 ENOS INTERACTING PROTEIN NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG194011|UniProtKB=T1FVK5 T1FVK5 20212851 PTHR11699:SF302 ALDEHYDE DEHYDROGENASE-RELATED ALDEHYDE DEHYDROGENASE 2-RELATED oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 dehydrogenase#PC00092;oxidoreductase#PC00176 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HELRO|EnsemblGenome=HelroG179939|UniProtKB=T1FF98 T1FF98 20207497 PTHR13843:SF12 MICROTUBULE-ASSOCIATED PROTEIN ATPASE F1_V1_A1 COMPLEX ALPHA_BETA SUBUNIT NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG194703|UniProtKB=T1FWC1 T1FWC1 20213117 PTHR11304:SF29 EPHRIN EPHRIN protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 neuron projection guidance#GO:0097485;signal transduction#GO:0007165;neurogenesis#GO:0022008;cell projection organization#GO:0030030;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;regulation of biological process#GO:0050789;system development#GO:0048731;cell differentiation#GO:0030154;axon guidance#GO:0007411;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;axonogenesis#GO:0007409;plasma membrane bounded cell projection morphogenesis#GO:0120039;signaling#GO:0023052;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;multicellular organism development#GO:0007275;cell morphogenesis#GO:0000902;cellular component organization#GO:0016043;cell communication#GO:0007154;cellular process#GO:0009987;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;neuron projection development#GO:0031175;axon development#GO:0061564;enzyme-linked receptor protein signaling pathway#GO:0007167;cell morphogenesis involved in neuron differentiation#GO:0048667;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 membrane-bound signaling molecule#PC00152;intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG186073|UniProtKB=T1FNM7 T1FNM7 20210424 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG81275|UniProtKB=T1G4C4 T1G4C4 20215922 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG151400|UniProtKB=T1EKK2 T1EKK2 20197102 PTHR10032:SF271 ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS RH12261P-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG194521|UniProtKB=T1FW56 T1FW56 20213052 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG166571|UniProtKB=T1EY95 T1EY95 20201545 PTHR13101:SF1 PHOSPHOMEVALONATE KINASE PHOSPHOMEVALONATE KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;phosphotransferase activity, phosphate group as acceptor#GO:0016776 sterol metabolic process#GO:0016125;cellular aromatic compound metabolic process#GO:0006725;lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;sulfur compound metabolic process#GO:0006790;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;alcohol biosynthetic process#GO:0046165;cholesterol biosynthetic process#GO:0006695;cholesterol metabolic process#GO:0008203;organic hydroxy compound biosynthetic process#GO:1901617;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;steroid metabolic process#GO:0008202;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;secondary alcohol biosynthetic process#GO:1902653;secondary alcohol metabolic process#GO:1902652;amide metabolic process#GO:0043603;purine nucleotide metabolic process#GO:0006163;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;organic hydroxy compound metabolic process#GO:1901615;heterocycle metabolic process#GO:0046483;acyl-CoA metabolic process#GO:0006637;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;alcohol metabolic process#GO:0006066;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;isoprenoid metabolic process#GO:0006720;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;isoprenoid biosynthetic process#GO:0008299;organophosphate metabolic process#GO:0019637;small molecule biosynthetic process#GO:0044283;cellular lipid metabolic process#GO:0044255;nucleotide metabolic process#GO:0009117;steroid biosynthetic process#GO:0006694;sterol biosynthetic process#GO:0016126;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 kinase#PC00137 Cholesterol biosynthesis#P00014>Phosphomevalonate kinase#P00500 HELRO|EnsemblGenome=HelroG175453|UniProtKB=T1F997 T1F997 20205396 PTHR43437:SF3 HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL-RELATED HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;catalytic activity#GO:0003824;hydro-lyase activity#GO:0016836 organic acid biosynthetic process#GO:0016053;lipid metabolic process#GO:0006629;oxoacid metabolic process#GO:0043436;monocarboxylic acid biosynthetic process#GO:0072330;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;fatty acid metabolic process#GO:0006631;small molecule biosynthetic process#GO:0044283;cellular lipid metabolic process#GO:0044255;carboxylic acid metabolic process#GO:0019752;small molecule metabolic process#GO:0044281;fatty acid biosynthetic process#GO:0006633;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG157371|UniProtKB=T1EMA4 T1EMA4 20197704 PTHR24351:SF249 RIBOSOMAL PROTEIN S6 KINASE PROTEIN KINASE C transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG84240|UniProtKB=T1G5G2 T1G5G2 20216309 PTHR21100:SF9 PREFOLDIN SUBUNIT 4 PREFOLDIN SUBUNIT 4 protein binding#GO:0005515;unfolded protein binding#GO:0051082;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG183591|UniProtKB=T1FJW3 T1FJW3 20209112 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170248|UniProtKB=T1F2U0 T1F2U0 20203139 PTHR24250:SF67 CHYMOTRYPSIN-RELATED PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG189500|UniProtKB=T1FR38 T1FR38 20211285 PTHR22881:SF27 BROMODOMAIN CONTAINING PROTEIN BROMODOMAIN CONTAINING 7_9 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG79826|UniProtKB=T1G3T9 T1G3T9 20215737 PTHR12294:SF13 EF HAND DOMAIN FAMILY A1,A2-RELATED MITOCHONDRIAL CALCIUM UPTAKE 3, ISOFORM D cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;calcium ion transport#GO:0006816;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;mitochondrial transport#GO:0006839;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation transport#GO:0006812;mitochondrial calcium ion homeostasis#GO:0051560;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;mitochondrial transmembrane transport#GO:1990542;monoatomic cation transmembrane transport#GO:0098655 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;transporter complex#GO:1990351;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;calcium channel complex#GO:0034704;membrane#GO:0016020;organelle envelope#GO:0031967;cation channel complex#GO:0034703;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;mitochondrial envelope#GO:0005740;transmembrane transporter complex#GO:1902495;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;mitochondrial protein-containing complex#GO:0098798 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG191091|UniProtKB=T1FSL0 T1FSL0 20211807 PTHR45960:SF2 GRB2-ASSOCIATED-BINDING PROTEIN PROTEIN DAUGHTER OF SEVENLESS scaffold/adaptor protein#PC00226 EGF receptor signaling pathway#P00018>Gab#P00563 HELRO|EnsemblGenome=HelroG162697|UniProtKB=T1ET09 T1ET09 20199709 PTHR46601:SF1 ULP_PROTEASE DOMAIN-CONTAINING PROTEIN ADF-H DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG85944|UniProtKB=T1G648 T1G648 20216545 PTHR10778:SF10 SOLUTE CARRIER FAMILY 35 MEMBER B SOLUTE CARRIER FAMILY 35 MEMBER B1 carbohydrate derivative transmembrane transporter activity#GO:1901505;nucleobase-containing compound transmembrane transporter activity#GO:0015932;transmembrane transporter activity#GO:0022857;UDP-galactose transmembrane transporter activity#GO:0005459;nucleotide-sugar transmembrane transporter activity#GO:0005338;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215 localization#GO:0051179;organic substance transport#GO:0071702;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;organic anion transport#GO:0015711;nucleobase-containing compound transport#GO:0015931;nucleotide-sugar transmembrane transport#GO:0015780;transport#GO:0006810;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264 bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;Golgi membrane#GO:0000139;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG111950|UniProtKB=T1EFF9 T1EFF9 20195311 PTHR13872:SF1 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG160835|UniProtKB=T1EQS9 T1EQS9 20198929 PTHR23507:SF1 ZGC:174356 FI18259P1-RELATED Endothelin signaling pathway#P00019>Adenylate cyclase#P00569 HELRO|EnsemblGenome=HelroG188091|UniProtKB=T1FPM2 T1FPM2 20210769 PTHR43215:SF14 RADIAL SPOKE HEAD 1 HOMOLOG RADIAL SPOKE HEAD 1 HOMOLOG HELRO|EnsemblGenome=HelroG87830|UniProtKB=T1G6W0 T1G6W0 20216807 PTHR11214:SF364 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE HEXOSYLTRANSFERASE transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG185582|UniProtKB=T1FN03 T1FN03 20210202 PTHR13313:SF0 CYTOCHROME C OXIDASE SUBUNIT VIIC CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL mitochondrial ATP synthesis coupled electron transport#GO:0042775;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;respiratory electron transport chain#GO:0022904;generation of precursor metabolites and energy#GO:0006091;aerobic electron transport chain#GO:0019646;oxidative phosphorylation#GO:0006119;electron transport chain#GO:0022900;ATP synthesis coupled electron transport#GO:0042773;cellular metabolic process#GO:0044237;cellular process#GO:0009987;mitochondrial electron transport, cytochrome c to oxygen#GO:0006123;energy derivation by oxidation of organic compounds#GO:0015980;metabolic process#GO:0008152 oxidase#PC00175;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG189197|UniProtKB=T1FQS0 T1FQS0 20211167 PTHR11516:SF60 PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;sulfur compound metabolic process#GO:0006790;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;amide metabolic process#GO:0043603;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;heterocycle metabolic process#GO:0046483;acyl-CoA metabolic process#GO:0006637;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;monocarboxylic acid metabolic process#GO:0032787;purine ribonucleotide metabolic process#GO:0009150;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;carboxylic acid metabolic process#GO:0019752;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 dehydrogenase#PC00092;oxidoreductase#PC00176 TCA cycle#P00051>Pyruvate Dehydrogenase#P01266;Pyruvate metabolism#P02772>Pyruvate Dehydrogenase#P03133 HELRO|EnsemblGenome=HelroG95795|UniProtKB=T1G977 T1G977 20217624 PTHR12745:SF6 SUPPRESSION OF TUMORIGENICITY 7 PROTEIN ST7 HOMOLOG HELRO|EnsemblGenome=HelroG163691|UniProtKB=T1EUD0 T1EUD0 20200180 PTHR24072:SF192 RHO FAMILY GTPASE CDC42 HOMOLOG GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;enzyme binding#GO:0019899;ribonucleoside triphosphate phosphatase activity#GO:0017111;kinase binding#GO:0019900;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817;heterocyclic compound binding#GO:1901363;protein kinase binding#GO:0019901;anion binding#GO:0043168;ion binding#GO:0043167 small GTPase#PC00208 TGF-beta signaling pathway#P00052>Ras-GDP#P01291;Huntington disease#P00029>Rac#P00775;Cytoskeletal regulation by Rho GTPase#P00016>Cdc42#P00515;Ras Pathway#P04393>Cdc42#P04569;p38 MAPK pathway#P05918>Cdc42#P06041;TGF-beta signaling pathway#P00052>Ras-GTP#P01280;Axon guidance mediated by netrin#P00009>cdc42#P00364;Integrin signalling pathway#P00034>Cdc42#P00938;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Cdc42#P00834;Axon guidance mediated by Slit/Robo#P00008>Cdc42#P00349;FGF signaling pathway#P00021>Rac#P00645 HELRO|EnsemblGenome=HelroG183706|UniProtKB=T1FK31 T1FK31 20209180 PTHR36191:SF1 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177776|UniProtKB=T1FC87 T1FC87 20206436 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG144663|UniProtKB=T1EJF6 T1EJF6 20196706 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG142806|UniProtKB=T1EJ77 T1EJ77 20196627 PTHR47978:SF40 FAMILY NOT NAMED RAS-RELATED PROTEIN RAB-33 GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 cytoplasm#GO:0005737;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG62237|UniProtKB=T1FWX6 T1FWX6 20213324 PTHR24248:SF185 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR DOPAMINE RECEPTOR 2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;regulation of cell communication#GO:0010646;cellular response to stimulus#GO:0051716;regulation of MAPK cascade#GO:0043408;signal transduction#GO:0007165;positive regulation of signal transduction#GO:0009967;regulation of signaling#GO:0023051;cell communication#GO:0007154;cellular process#GO:0009987;regulation of intracellular signal transduction#GO:1902531;positive regulation of MAPK cascade#GO:0043410;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;positive regulation of response to stimulus#GO:0048584;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;positive regulation of cell communication#GO:0010647;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HELRO|EnsemblGenome=HelroG173575|UniProtKB=T1F6Z4 T1F6Z4 20204593 PTHR24230:SF75 G-PROTEIN COUPLED RECEPTOR RELAXIN FAMILY PEPTIDE RECEPTOR 3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;neuropeptide signaling pathway#GO:0007218;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG194865|UniProtKB=T1FWI1 T1FWI1 20213176 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG173408|UniProtKB=T1F6S4 T1F6S4 20204523 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG103347|UniProtKB=T1EDF6 T1EDF6 20194608 PTHR30389:SF0 FUMARATE HYDRATASE-RELATED FUMARATE HYDRATASE CLASS I, AEROBIC lyase#PC00144;hydratase#PC00120 HELRO|EnsemblGenome=HelroG166858|UniProtKB=T1EYN2 T1EYN2 20201682 PTHR47510:SF3 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194305|UniProtKB=T1FVW8 T1FVW8 20212964 PTHR22883:SF452 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular localization#GO:0051641;macromolecule localization#GO:0033036;macromolecule modification#GO:0043412;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;biosynthetic process#GO:0009058;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;protein palmitoylation#GO:0018345;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;localization within membrane#GO:0051668;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein localization to membrane#GO:0072657;organonitrogen compound biosynthetic process#GO:1901566;protein targeting#GO:0006605;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;protein acylation#GO:0043543;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipoprotein biosynthetic process#GO:0042158;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;lipoprotein metabolic process#GO:0042157 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG183309|UniProtKB=T1FJG0 T1FJG0 20208959 PTHR32141:SF179 FAMILY NOT NAMED F-BOX DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159973|UniProtKB=T1EPL9 T1EPL9 20198519 PTHR21838:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 137 COILED-COIL DOMAIN-CONTAINING PROTEIN 137 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG173604|UniProtKB=T1F710 T1F710 20204609 PTHR47032:SF1 UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG95765|UniProtKB=T1G974 T1G974 20217621 PTHR46314:SF2 SOLUTE CARRIER FAMILY 25 MEMBER 44 SOLUTE CARRIER FAMILY 25 MEMBER 44 transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;branched-chain amino acid transmembrane transporter activity#GO:0015658;amino acid transmembrane transporter activity#GO:0015171;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;establishment of localization#GO:0051234;amino acid transport#GO:0006865;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;branched-chain amino acid transport#GO:0015803;nitrogen compound transport#GO:0071705;carboxylic acid transport#GO:0046942 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG189222|UniProtKB=T1FQT6 T1FQT6 20211183 PTHR23120:SF0 MAESTRO-RELATED HEAT DOMAIN-CONTAINING MAESTRO HEAT-LIKE REPEAT FAMILY MEMBER 1 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG85046|UniProtKB=T1G5S0 T1G5S0 20216417 PTHR15323:SF6 D123 PROTEIN CELL DIVISION CYCLE PROTEIN 123 HOMOLOG cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG67329|UniProtKB=T1FYZ7 T1FYZ7 20214045 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161769|UniProtKB=T1ERW1 T1ERW1 20199311 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED BRCT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190005|UniProtKB=T1FRK9 T1FRK9 20211456 PTHR23119:SF44 DISCS LARGE PROTEIN LAP4 enzyme binding#GO:0019899;protein binding#GO:0005515;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900 establishment or maintenance of cell polarity#GO:0007163;localization within membrane#GO:0051668;cellular localization#GO:0051641;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;developmental process#GO:0032502;multicellular organism development#GO:0007275;cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987;protein localization#GO:0008104;localization#GO:0051179;embryo development#GO:0009790;cellular macromolecule localization#GO:0070727;anatomical structure development#GO:0048856;establishment or maintenance of apical/basal cell polarity#GO:0035088;multicellular organismal process#GO:0032501;receptor clustering#GO:0043113;establishment or maintenance of bipolar cell polarity#GO:0061245;protein-containing complex localization#GO:0031503 basal plasma membrane#GO:0009925;anchoring junction#GO:0070161;cell-cell junction#GO:0005911;basolateral plasma membrane#GO:0016323;cell junction#GO:0030054;plasma membrane region#GO:0098590;adherens junction#GO:0005912;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;basal part of cell#GO:0045178;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG177326|UniProtKB=T1FBI1 T1FBI1 20206180 PTHR31199:SF1 ARPIN ARPIN negative regulation of biological process#GO:0048519;regulation of organelle organization#GO:0033043;regulation of actin filament organization#GO:0110053;regulation of cellular component organization#GO:0051128;negative regulation of supramolecular fiber organization#GO:1902904;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;negative regulation of organelle organization#GO:0010639;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;regulation of actin filament-based process#GO:0032970;negative regulation of cellular component organization#GO:0051129;negative regulation of cytoskeleton organization#GO:0051494;negative regulation of cellular process#GO:0048523 HELRO|EnsemblGenome=HelroG190606|UniProtKB=T1FS46 T1FS46 20211643 PTHR12480:SF19 ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD CUPIN-LIKE DOMAIN-CONTAINING PROTEIN sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;dioxygenase activity#GO:0051213;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491 positive regulation of gene expression#GO:0010628;positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;macromolecule modification#GO:0043412;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;protein modification process#GO:0036211;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;protein hydroxylation#GO:0018126;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;protein metabolic process#GO:0019538;positive regulation of biological process#GO:0048518;positive regulation of translation#GO:0045727;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;regulation of protein-containing complex disassembly#GO:0043244;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;primary metabolic process#GO:0044238;regulation of primary metabolic process#GO:0080090;positive regulation of protein metabolic process#GO:0051247;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;regulation of translation#GO:0006417;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185711|UniProtKB=T1FN66 T1FN66 20210264 PTHR21141:SF5 60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER LARGE RIBOSOMAL SUBUNIT PROTEIN P2 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG180356|UniProtKB=T1FFT4 T1FFT4 20207683 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN SI:DKEY-17M8.2 HELRO|EnsemblGenome=HelroG65652|UniProtKB=T1FYB1 T1FYB1 20213809 PTHR11783:SF100 SULFOTRANSFERASE SULT SULFOTRANSFERASE SSU-1 sulfotransferase activity#GO:0008146;transferase activity#GO:0016740;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity#GO:0003824 cellular metabolic process#GO:0044237;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG169960|UniProtKB=T1F2H3 T1F2H3 20203023 PTHR19282:SF516 TETRASPANIN TETRASPANIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185802|UniProtKB=T1FNB1 T1FNB1 20210308 PTHR10551:SF9 FASCIN FASCIN-2 cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 establishment or maintenance of cell polarity#GO:0007163;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;actin filament bundle assembly#GO:0051017;cell motility#GO:0048870;cellular component organization#GO:0016043;actin filament bundle organization#GO:0061572;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cell migration#GO:0016477 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG180343|UniProtKB=T1FFS5 T1FFS5 20207674 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168118|UniProtKB=T1F067 T1F067 20202217 PTHR23322:SF96 FAS-ASSOCIATED PROTEIN FAS-ASSOCIATED FACTOR 1 protein binding#GO:0005515;ubiquitin-like protein binding#GO:0032182;binding#GO:0005488;ubiquitin binding#GO:0043130 response to organic substance#GO:0010033;macromolecule catabolic process#GO:0009057;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;response to organonitrogen compound#GO:0010243;ERAD pathway#GO:0036503;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 FAS signaling pathway#P00020>FAF1#P00609 HELRO|EnsemblGenome=HelroG127781|UniProtKB=T1EHH9 T1EHH9 20196029 PTHR23235:SF148 KRUEPPEL-LIKE TRANSCRIPTION FACTOR ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 5B-LIKE sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG180732|UniProtKB=T1FG78 T1FG78 20207827 PTHR43725:SF32 UDP-GLUCOSE 4-EPIMERASE NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN racemase and epimerase activity, acting on carbohydrates and derivatives#GO:0016857;isomerase activity#GO:0016853;catalytic activity#GO:0003824 monosaccharide metabolic process#GO:0005996;carbohydrate metabolic process#GO:0005975;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 epimerase/racemase#PC00096;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG79613|UniProtKB=T1G3Q8 T1G3Q8 20215706 PTHR33332:SF48 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194811|UniProtKB=T1FWF8 T1FWF8 20213153 PTHR11905:SF159 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG187231|UniProtKB=T1FP79 T1FP79 20210626 PTHR11223:SF2 EXPORTIN 1/5 EXPORTIN-1 cellular component biogenesis#GO:0044085;ribosomal subunit export from nucleus#GO:0000054;cellular localization#GO:0051641;organelle localization#GO:0051640;transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;ribonucleoprotein complex biogenesis#GO:0022613;establishment of localization in cell#GO:0051649;ribosome biogenesis#GO:0042254;intracellular transport#GO:0046907;establishment of organelle localization#GO:0051656;nuclear transport#GO:0051169;protein-containing complex localization#GO:0031503 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG186312|UniProtKB=T1FNY4 T1FNY4 20210531 PTHR24250:SF27 CHYMOTRYPSIN-RELATED ELASTASE 2 LIKE hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG180872|UniProtKB=T1FGC8 T1FGC8 20207877 PTHR31816:SF3 MICOS COMPLEX SUBUNIT MIC13 MICOS COMPLEX SUBUNIT MIC13 cellular component organization or biogenesis#GO:0071840;membrane organization#GO:0061024;organelle organization#GO:0006996;cellular component organization#GO:0016043;mitochondrial membrane organization#GO:0007006;mitochondrion organization#GO:0007005;cellular process#GO:0009987;inner mitochondrial membrane organization#GO:0007007 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle membrane contact site#GO:0044232;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;mitochondrial protein-containing complex#GO:0098798 HELRO|EnsemblGenome=HelroG166651|UniProtKB=T1EYB8 T1EYB8 20201568 PTHR24104:SF47 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED E3 UBIQUITIN-PROTEIN LIGASE NHLRC1 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG179818|UniProtKB=T1FF67 T1FF67 20207466 PTHR31534:SF11 ATAXIN 7, ISOFORM A ATAXIN 7, ISOFORM A HELRO|EnsemblGenome=HelroG167648|UniProtKB=T1EZM1 T1EZM1 20202021 PTHR31804:SF2 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15 CUE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG108638|UniProtKB=T1EEL2 T1EEL2 20195014 PTHR11616:SF321 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;organic acid:sodium symporter activity#GO:0005343;organic acid transmembrane transporter activity#GO:0005342;symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;organic anion transmembrane transporter activity#GO:0008514;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;amino acid:sodium symporter activity#GO:0005283;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;amino acid transmembrane transporter activity#GO:0015171;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;organic anion transport#GO:0015711;amino acid transport#GO:0006865;organic acid transport#GO:0015849;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;nitrogen compound transport#GO:0071705;carboxylic acid transport#GO:0046942;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;amino acid import across plasma membrane#GO:0089718;carboxylic acid transmembrane transport#GO:1905039;localization#GO:0051179;organic substance transport#GO:0071702;import across plasma membrane#GO:0098739;amino acid transmembrane transport#GO:0003333;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transport#GO:0006812;organic acid transmembrane transport#GO:1903825;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>CHT1#P01084 HELRO|EnsemblGenome=HelroG185292|UniProtKB=T1FMM3 T1FMM3 20210072 PTHR21064:SF1 AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED HYDROXYLYSINE KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301 HELRO|EnsemblGenome=HelroG97665|UniProtKB=T1G9I5 T1G9I5 20217732 PTHR11388:SF100 ORGANIC ANION TRANSPORTER SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 4A1 transporter#PC00227 HELRO|EnsemblGenome=HelroG92624|UniProtKB=T1G8J0 T1G8J0 20217387 PTHR12270:SF25 GLYCOSYLTRANSFERASE-RELATED GLYCOSYLTRANSFERASE-LIKE PROTEIN LARGE glucuronosyltransferase activity#GO:0015020;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;UDP-glycosyltransferase activity#GO:0008194;pentosyltransferase activity#GO:0016763;xylosyltransferase activity#GO:0042285;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;protein O-linked mannosylation#GO:0035269;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein mannosylation#GO:0035268;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085;mannosylation#GO:0097502 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG175607|UniProtKB=T1F9F1 T1F9F1 20205450 PTHR25462:SF305 BONUS, ISOFORM C-RELATED RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG194439|UniProtKB=T1FW20 T1FW20 20213016 PTHR43049:SF1 EARLY ENDOSOME ANTIGEN EARLY ENDOSOME ANTIGEN HELRO|EnsemblGenome=HelroG188241|UniProtKB=T1FPT0 T1FPT0 20210827 PTHR13462:SF10 CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;secondary active transmembrane transporter activity#GO:0015291;inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;inorganic cation transmembrane transporter activity#GO:0022890 inorganic ion homeostasis#GO:0098771;metal ion transport#GO:0030001;calcium ion homeostasis#GO:0055074;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;inorganic ion transmembrane transport#GO:0098660;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;calcium ion transport#GO:0006816;intracellular calcium ion homeostasis#GO:0006874;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;mitochondrial transport#GO:0006839;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation transport#GO:0006812;mitochondrial calcium ion homeostasis#GO:0051560;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;mitochondrial transmembrane transport#GO:1990542;monoatomic cation transmembrane transport#GO:0098655 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;transporter complex#GO:1990351;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;calcium channel complex#GO:0034704;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;cation channel complex#GO:0034703;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;mitochondrial envelope#GO:0005740;transmembrane transporter complex#GO:1902495;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;mitochondrial protein-containing complex#GO:0098798 HELRO|EnsemblGenome=HelroG185906|UniProtKB=T1FNF3 T1FNF3 20210350 PTHR12329:SF16 BCL2-ASSOCIATED ATHANOGENE BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1 nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;molecular function regulator activity#GO:0098772;nucleoside phosphate binding#GO:1901265;protein binding#GO:0005515;heterocyclic compound binding#GO:1901363;protein-folding chaperone binding#GO:0051087 biological regulation#GO:0065007;regulation of protein stability#GO:0031647;regulation of biological quality#GO:0065008;protein stabilization#GO:0050821 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 Apoptosis signaling pathway#P00006>Bag#P00278 HELRO|EnsemblGenome=HelroG195043|UniProtKB=T1FWP5 T1FWP5 20213240 PTHR21284:SF12 EG:80H7.2 PROTEIN EG:80H7.2 PROTEIN HELRO|EnsemblGenome=HelroG162424|UniProtKB=T1ESM8 T1ESM8 20199578 PTHR11686:SF9 GAMMA GLUTAMYL TRANSPEPTIDASE RE13973P hydrolase activity#GO:0016787;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 sulfur compound metabolic process#GO:0006790;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;peptide catabolic process#GO:0043171;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;cellular process#GO:0009987;glutathione metabolic process#GO:0006749;sulfur compound catabolic process#GO:0044273;nitrogen compound metabolic process#GO:0006807;cellular modified amino acid metabolic process#GO:0006575;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG177300|UniProtKB=T1FBH2 T1FBH2 20206171 PTHR23011:SF41 CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG163338|UniProtKB=T1ETX7 T1ETX7 20200027 PTHR47023:SF1 SEX PEPTIDE RECEPTOR SEX PEPTIDE RECEPTOR transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG192725|UniProtKB=T1FU83 T1FU83 20212379 PTHR14326:SF44 TARGETING PROTEIN FOR XKLP2 TARGETING PROTEIN FOR XKLP2 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG190619|UniProtKB=T1FS53 T1FS53 20211650 PTHR10026:SF7 CYCLIN CYCLIN-C protein kinase regulator activity#GO:0019887;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 kinase activator#PC00138 HELRO|EnsemblGenome=HelroG140021|UniProtKB=T1EIZ8 T1EIZ8 20196548 PTHR11616:SF321 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;organic acid:sodium symporter activity#GO:0005343;organic acid transmembrane transporter activity#GO:0005342;symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;organic anion transmembrane transporter activity#GO:0008514;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;amino acid:sodium symporter activity#GO:0005283;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;amino acid transmembrane transporter activity#GO:0015171;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;organic anion transport#GO:0015711;amino acid transport#GO:0006865;organic acid transport#GO:0015849;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;nitrogen compound transport#GO:0071705;carboxylic acid transport#GO:0046942;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;amino acid import across plasma membrane#GO:0089718;carboxylic acid transmembrane transport#GO:1905039;localization#GO:0051179;organic substance transport#GO:0071702;import across plasma membrane#GO:0098739;amino acid transmembrane transport#GO:0003333;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transport#GO:0006812;organic acid transmembrane transport#GO:1903825;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>CHT1#P01084 HELRO|EnsemblGenome=HelroG170381|UniProtKB=T1F2Z2 T1F2Z2 20203191 PTHR24379:SF127 KRAB AND ZINC FINGER DOMAIN-CONTAINING BLOODY FINGERS-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG157613|UniProtKB=T1EMD9 T1EMD9 20197739 PTHR13256:SF16 N-ACETYLTRANSFERASE 9 ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9 HELRO|EnsemblGenome=HelroG165411|UniProtKB=T1EWQ9 T1EWQ9 20201009 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG108893|UniProtKB=T1EEN5 T1EEN5 20195037 PTHR48092:SF30 KNIRPS-RELATED PROTEIN-RELATED ECDYSONE RECEPTOR cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;signaling receptor activity#GO:0038023;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG169161|UniProtKB=T1F1I2 T1F1I2 20202682 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168451|UniProtKB=T1F0L8 T1F0L8 20202368 PTHR45818:SF3 PROTEIN VAV PROTEIN VAV nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;regulation of GTPase activity#GO:0043087;regulation of molecular function#GO:0065009 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 PDGF signaling pathway#P00047>Vav#P01169 HELRO|EnsemblGenome=HelroG84564|UniProtKB=T1G5K4 T1G5K4 20216351 PTHR20934:SF0 TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG basal RNA polymerase II transcription machinery binding#GO:0001099;RNA polymerase binding#GO:0070063;binding#GO:0005488;RNA polymerase core enzyme binding#GO:0043175;RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515;enzyme binding#GO:0019899;basal transcription machinery binding#GO:0001098 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;DNA-templated transcription elongation#GO:0006354;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nucleobase-containing compound biosynthetic process#GO:0034654;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;transcription elongation by RNA polymerase II#GO:0006368;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 HELRO|EnsemblGenome=HelroG116286|UniProtKB=T1EGE0 T1EGE0 20195642 PTHR24392:SF49 ZINC FINGER PROTEIN PROTEIN HUNCHBACK C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG97005|UniProtKB=T1G9E9 T1G9E9 20217696 PTHR20856:SF7 DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;RNA polymerase activity#GO:0097747;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG113698|UniProtKB=T1EFV3 T1EFV3 20195455 PTHR12558:SF9 CELL DIVISION CYCLE 16,23,27 CELL DIVISION CYCLE PROTEIN 16 HOMOLOG cell division#GO:0051301;regulation of mitotic nuclear division#GO:0007088;regulation of chromosome segregation#GO:0051983;positive regulation of organelle organization#GO:0010638;macromolecule modification#GO:0043412;regulation of chromosome separation#GO:1905818;protein catabolic process#GO:0030163;organonitrogen compound catabolic process#GO:1901565;protein modification process#GO:0036211;regulation of cellular component organization#GO:0051128;positive regulation of cell cycle#GO:0045787;post-translational protein modification#GO:0043687;modification-dependent macromolecule catabolic process#GO:0043632;regulation of biological process#GO:0050789;nitrogen compound metabolic process#GO:0006807;positive regulation of cell cycle process#GO:0090068;positive regulation of mitotic cell cycle#GO:0045931;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;positive regulation of biological process#GO:0048518;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;regulation of chromosome organization#GO:0033044;macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;regulation of mitotic sister chromatid separation#GO:0010965;regulation of nuclear division#GO:0051783;protein modification by small protein conjugation or removal#GO:0070647;regulation of mitotic cell cycle phase transition#GO:1901990;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of organelle organization#GO:0033043;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;positive regulation of mitotic nuclear division#GO:0045840;regulation of cell cycle phase transition#GO:1901987;organonitrogen compound metabolic process#GO:1901564;cellular process#GO:0009987;regulation of mitotic metaphase/anaphase transition#GO:0030071;primary metabolic process#GO:0044238;regulation of cell cycle process#GO:0010564;positive regulation of cellular process#GO:0048522;ubiquitin-dependent protein catabolic process#GO:0006511;anaphase-promoting complex-dependent catabolic process#GO:0031145;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;regulation of cell cycle#GO:0051726;regulation of sister chromatid segregation#GO:0033045;regulation of mitotic cell cycle#GO:0007346 ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234;anaphase-promoting complex#GO:0005680;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG77936|UniProtKB=T1G356 T1G356 20215504 PTHR24006:SF887 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG73126|UniProtKB=T1G1A5 T1G1A5 20214853 PTHR12689:SF4 A1 CISTRON SPLICING FACTOR AAR2-RELATED PROTEIN AAR2 HOMOLOG cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;spliceosomal snRNP assembly#GO:0000387;organic substance metabolic process#GO:0071704;mRNA splicing, via spliceosome#GO:0000398;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG184873|UniProtKB=T1FM40 T1FM40 20209889 PTHR10980:SF3 RHO GDP-DISSOCIATION INHIBITOR LD16419P nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052;Rho protein signal transduction#GO:0007266 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG76830|UniProtKB=T1G2P8 T1G2P8 20215346 PTHR45659:SF4 HOMEOBOX PROTEIN HOX HOMEOBOX PROTEIN ABDOMINAL-A sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regionalization#GO:0003002;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;anterior/posterior pattern specification#GO:0009952;multicellular organismal process#GO:0032501;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;pattern specification process#GO:0007389;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG181782|UniProtKB=T1FHB4 T1FHB4 20208213 PTHR48012:SF18 STERILE20-LIKE KINASE, ISOFORM B-RELATED HAPPYHOUR, ISOFORM A transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Apoptosis signaling pathway#P00006>GCKR#P00311;Apoptosis signaling pathway#P00006>GCK#P00268 HELRO|EnsemblGenome=HelroG89804|UniProtKB=T1G7H9 T1G7H9 20217026 PTHR45810:SF17 HISTONE H3.2 HISTONE H3-LIKE CENTROMERIC PROTEIN A chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG174211|UniProtKB=T1F7T0 T1F7T0 20204879 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG66975|UniProtKB=T1FYU4 T1FYU4 20213992 PTHR23280:SF21 4.1 G PROTEIN PROTEIN 4.1 HOMOLOG cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG192241|UniProtKB=T1FTR2 T1FTR2 20212209 PTHR24104:SF51 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG99525|UniProtKB=T1G9T2 T1G9T2 20217828 PTHR12233:SF1 VACUOLAR PROTEIN SORTING 26 RELATED VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 26 endosomal transport#GO:0016197;cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;cytosolic transport#GO:0016482;establishment of protein localization#GO:0045184;retrograde transport, endosome to Golgi#GO:0042147;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;endosome#GO:0005768;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG181388|UniProtKB=T1FGY4 T1FGY4 20208083 PTHR22792:SF131 LUPUS LA PROTEIN-RELATED LA-RELATED PROTEIN LARP4B nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159;mRNA 3'-UTR binding#GO:0003730 positive regulation of gene expression#GO:0010628;positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of protein metabolic process#GO:0051247;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biological process#GO:0048518;positive regulation of translation#GO:0045727;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;cytosol#GO:0005829;cytoplasmic stress granule#GO:0010494;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG108901|UniProtKB=T1EEN6 T1EEN6 20195038 PTHR32546:SF25 G-PROTEIN COUPLED RECEPTOR 158-RELATED MIP05539P G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG194240|UniProtKB=T1FVU7 T1FVU7 20212943 PTHR14728:SF2 PROTEIN AURORA BOREALIS PROTEIN AURORA BOREALIS enzyme binding#GO:0019899;protein binding#GO:0005515;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of microtubule-based process#GO:0032886;regulation of mitotic nuclear division#GO:0007088;regulation of protein modification process#GO:0031399;regulation of phosphate metabolic process#GO:0019220;regulation of protein metabolic process#GO:0051246;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;positive regulation of molecular function#GO:0044093;activation of protein kinase activity#GO:0032147;regulation of cellular component organization#GO:0051128;regulation of catalytic activity#GO:0050790;positive regulation of protein modification process#GO:0031401;regulation of mitotic spindle organization#GO:0060236;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;regulation of cytoskeleton organization#GO:0051493;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;regulation of microtubule cytoskeleton organization#GO:0070507;positive regulation of biological process#GO:0048518;regulation of kinase activity#GO:0043549;regulation of protein kinase activity#GO:0045859;positive regulation of protein phosphorylation#GO:0001934;positive regulation of phosphorylation#GO:0042327;regulation of nuclear division#GO:0051783;positive regulation of catalytic activity#GO:0043085;regulation of organelle organization#GO:0033043;positive regulation of phosphorus metabolic process#GO:0010562;positive regulation of macromolecule metabolic process#GO:0010604;regulation of cell cycle process#GO:0010564;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;positive regulation of protein metabolic process#GO:0051247;positive regulation of phosphate metabolic process#GO:0045937;regulation of macromolecule metabolic process#GO:0060255;positive regulation of protein kinase activity#GO:0045860;regulation of cellular process#GO:0050794;regulation of protein phosphorylation#GO:0001932;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;regulation of cell cycle#GO:0051726;regulation of transferase activity#GO:0051338;regulation of mitotic cell cycle#GO:0007346;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG194796|UniProtKB=T1FWF2 T1FWF2 20213147 PTHR46575:SF1 AMYLOID PROTEIN-BINDING PROTEIN 2 AMYLOID PROTEIN-BINDING PROTEIN 2 ubiquitin ligase-substrate adaptor activity#GO:1990756;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234 HELRO|EnsemblGenome=HelroG175147|UniProtKB=T1F8X1 T1F8X1 20205270 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG161572|UniProtKB=T1ERM7 T1ERM7 20199227 PTHR11003:SF334 POTASSIUM CHANNEL, SUBFAMILY K FI03418P monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG186115|UniProtKB=T1FNP0 T1FNP0 20210437 PTHR12234:SF0 FORMIMINOTRANSFERASE-CYCLODEAMINASE FORMIMIDOYLTRANSFERASE-CYCLODEAMINASE HELRO|EnsemblGenome=HelroG178130|UniProtKB=T1FCT0 T1FCT0 20206629 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG156393|UniProtKB=T1ELV3 T1ELV3 20197553 PTHR11879:SF22 ASPARTATE AMINOTRANSFERASE ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL transaminase#PC00216;transferase#PC00220;metabolite interconversion enzyme#PC00262 Tyrosine biosynthesis#P02784>Aromatic amino acid aminotransferase#P03213;Asparagine and aspartate biosynthesis#P02730>Aspartate aminotransferase#P02854 HELRO|EnsemblGenome=HelroG117028|UniProtKB=T1EGJ4 T1EGJ4 20195696 PTHR10196:SF57 SUGAR KINASE XYLULOSE KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;carbohydrate kinase activity#GO:0019200;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 organic hydroxy compound metabolic process#GO:1901615;monosaccharide metabolic process#GO:0005996;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;alcohol metabolic process#GO:0006066;cellular process#GO:0009987;carbohydrate metabolic process#GO:0005975;phosphorus metabolic process#GO:0006793;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 carbohydrate kinase#PC00065 Ascorbate degradation#P02729>L-xylulose kinase#P02849 HELRO|EnsemblGenome=HelroG70454|UniProtKB=T1G066 T1G066 20214464 PTHR15858:SF0 IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1 IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1 localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987 bounding membrane of organelle#GO:0098588;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;Golgi membrane#GO:0000139;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG156380|UniProtKB=T1ELU9 T1ELU9 20197549 PTHR10772:SF0 10 KDA HEAT SHOCK PROTEIN 10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL cation binding#GO:0043169;unfolded protein binding#GO:0051082;small molecule binding#GO:0036094;binding#GO:0005488;metal ion binding#GO:0046872;protein binding#GO:0005515;protein-folding chaperone binding#GO:0051087;ion binding#GO:0043167 macromolecule biosynthetic process#GO:0009059;chaperone cofactor-dependent protein refolding#GO:0051085;chaperone-mediated protein folding#GO:0061077;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein folding#GO:0006457;nitrogen compound metabolic process#GO:0006807;'de novo' protein folding#GO:0006458;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperonin#PC00073 HELRO|EnsemblGenome=HelroG183289|UniProtKB=T1FJF1 T1FJF1 20208950 PTHR21522:SF68 PROTON CHANNEL OTOP G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078;proton channel activity#GO:0015252;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;proton transmembrane transport#GO:1902600;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG73207|UniProtKB=T1G1B7 T1G1B7 20214865 PTHR11945:SF534 MADS BOX PROTEIN MYOCYTE-SPECIFIC ENHANCER FACTOR 2 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 MADS box transcription factor#PC00250 p38 MAPK pathway#P05918>MEF#P06023;Oxidative stress response#P00046>MEF-2#P01128 HELRO|EnsemblGenome=HelroG188452|UniProtKB=T1FQ02 T1FQ02 20210899 PTHR34031:SF1 CENTROSOMAL PROTEIN OF 162 KDA CENTROSOMAL PROTEIN OF 162 KDA organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031 supramolecular complex#GO:0099080;axoneme#GO:0005930;microtubule organizing center#GO:0005815;cytoplasmic microtubule#GO:0005881;cytoplasmic region#GO:0099568;supramolecular polymer#GO:0099081;cellular anatomical entity#GO:0110165;supramolecular fiber#GO:0099512;centriole#GO:0005814;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;ciliary plasm#GO:0097014;plasma membrane bounded cell projection cytoplasm#GO:0032838;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cytoskeleton#GO:0005856;cilium#GO:0005929;microtubule#GO:0005874;axonemal microtubule#GO:0005879 HELRO|EnsemblGenome=HelroG185604|UniProtKB=T1FN11 T1FN11 20210210 PTHR10019:SF5 SNF5 SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY B MEMBER 1 molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 protein-DNA complex organization#GO:0071824;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;cellular component organization#GO:0016043;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG155825|UniProtKB=T1ELM9 T1ELM9 20197479 PTHR10218:SF362 GTP-BINDING PROTEIN ALPHA SUBUNIT G PROTEIN ALPHA O SUBUNIT GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;ribonucleoside triphosphate phosphatase activity#GO:0017111;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 regulation of biological process#GO:0050789;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;side of membrane#GO:0098552;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;extrinsic component of membrane#GO:0019898 heterotrimeric G-protein#PC00117;G-protein#PC00020 Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Enkephalin release#P05913>G-Protein (i)#P05974;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;Opioid prodynorphin pathway#P05916>G-protein#P06002;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047 HELRO|EnsemblGenome=HelroG153318|UniProtKB=T1EL36 T1EL36 20197286 PTHR46289:SF17 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175224|UniProtKB=T1F914 T1F914 20205313 PTHR23119:SF51 DISCS LARGE DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN enzyme binding#GO:0019899;protein binding#GO:0005515;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900 establishment or maintenance of cell polarity#GO:0007163;localization within membrane#GO:0051668;cellular localization#GO:0051641;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;developmental process#GO:0032502;multicellular organism development#GO:0007275;cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987;protein localization#GO:0008104;localization#GO:0051179;embryo development#GO:0009790;cellular macromolecule localization#GO:0070727;anatomical structure development#GO:0048856;establishment or maintenance of apical/basal cell polarity#GO:0035088;multicellular organismal process#GO:0032501;receptor clustering#GO:0043113;establishment or maintenance of bipolar cell polarity#GO:0061245;protein-containing complex localization#GO:0031503 basal plasma membrane#GO:0009925;basolateral plasma membrane#GO:0016323;cell junction#GO:0030054;plasma membrane region#GO:0098590;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;basal part of cell#GO:0045178;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG108208|UniProtKB=T1EEG9 T1EEG9 20194971 PTHR11767:SF102 INWARD RECTIFIER POTASSIUM CHANNEL INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic cation channel activity#GO:0099094;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of localization#GO:0032879;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;import across plasma membrane#GO:0098739;regulation of transport#GO:0051049;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;regulation of monoatomic ion transport#GO:0043269;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;potassium ion transport#GO:0006813;potassium ion import across plasma membrane#GO:1990573 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG152110|UniProtKB=T1EKP1 T1EKP1 20197141 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG194683|UniProtKB=T1FWB2 T1FWB2 20213108 PTHR33395:SF21 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED PERICARDIN heart morphogenesis#GO:0003007;system development#GO:0048731;heart development#GO:0007507;circulatory system development#GO:0072359;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;animal organ development#GO:0048513;multicellular organism development#GO:0007275;developmental process#GO:0032502;animal organ morphogenesis#GO:0009887;multicellular organismal process#GO:0032501;cell adhesion#GO:0007155;cellular process#GO:0009987;post-embryonic development#GO:0009791 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG132793|UniProtKB=T1EHZ5 T1EHZ5 20196195 PTHR11893:SF36 INNEXIN INNEXIN-5 cell junction protein#PC00070;gap junction#PC00105 HELRO|EnsemblGenome=HelroG158911|UniProtKB=T1ENE2 T1ENE2 20198092 PTHR47160:SF5 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG87401|UniProtKB=T1G6P6 T1G6P6 20216743 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG107946|UniProtKB=T1EEE2 T1EEE2 20194944 PTHR42884:SF3 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED FURIN-LIKE PROTEASE 1, ISOFORMS 1_1-X_2 hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;protein metabolic process#GO:0019538;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 bounding membrane of organelle#GO:0098588;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791;Golgi membrane#GO:0000139 serine protease#PC00203;protein modifying enzyme#PC00260 Activin beta signaling pathway#P06210>FUR1#P06238;Endothelin signaling pathway#P00019>furin#P00575;GBB signaling pathway#P06214>FUR1#P06298;SCW signaling pathway#P06216>FUR1#P06333;DPP-SCW signaling pathway#P06212>FUR1#P06263;DPP signaling pathway#P06213>FUR1#P06290;ALP23B signaling pathway#P06209>FUR1#P06227;Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105;BMP/activin signaling pathway-drosophila#P06211>Furin#P06244;Alzheimer disease-presenilin pathway#P00004>Furin#P00157;MYO signaling pathway#P06215>FUR1#P06318 HELRO|EnsemblGenome=HelroG183160|UniProtKB=T1FJ85 T1FJ85 20208884 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG88580|UniProtKB=T1G740 T1G740 20216887 PTHR43691:SF11 URIDINE PHOSPHORYLASE FI09636P-RELATED cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 nucleotide kinase#PC00172 Salvage pyrimidine ribonucleotides#P02775>Uridine phosphorylase#P03152 HELRO|EnsemblGenome=HelroG172868|UniProtKB=T1F618 T1F618 20204267 PTHR11412:SF136 MACROGLOBULIN / COMPLEMENT CD109 ANTIGEN protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG168368|UniProtKB=T1F0H6 T1F0H6 20202326 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG152883|UniProtKB=T1EKX7 T1EKX7 20197227 PTHR33690:SF3 DUF4605 DOMAIN-CONTAINING PROTEIN UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG184051|UniProtKB=T1FKH6 T1FKH6 20209325 PTHR22765:SF416 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE GODZILLA transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG192304|UniProtKB=T1FTT3 T1FTT3 20212230 PTHR23119:SF44 DISCS LARGE PROTEIN LAP4 enzyme binding#GO:0019899;protein binding#GO:0005515;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900 establishment or maintenance of cell polarity#GO:0007163;localization within membrane#GO:0051668;cellular localization#GO:0051641;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;developmental process#GO:0032502;multicellular organism development#GO:0007275;cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987;protein localization#GO:0008104;localization#GO:0051179;embryo development#GO:0009790;cellular macromolecule localization#GO:0070727;anatomical structure development#GO:0048856;establishment or maintenance of apical/basal cell polarity#GO:0035088;multicellular organismal process#GO:0032501;receptor clustering#GO:0043113;establishment or maintenance of bipolar cell polarity#GO:0061245;protein-containing complex localization#GO:0031503 basal plasma membrane#GO:0009925;anchoring junction#GO:0070161;cell-cell junction#GO:0005911;basolateral plasma membrane#GO:0016323;cell junction#GO:0030054;plasma membrane region#GO:0098590;adherens junction#GO:0005912;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;basal part of cell#GO:0045178;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG176430|UniProtKB=T1FAI0 T1FAI0 20205829 PTHR43979:SF1 PRE-MRNA-PROCESSING FACTOR 17 PRE-MRNA-PROCESSING FACTOR 17 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;catalytic step 2 spliceosome#GO:0071013;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG76488|UniProtKB=T1G2K6 T1G2K6 20215304 PTHR10997:SF9 IMPORTIN-7, 8, 11 IMPORTIN-9 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;protein import into nucleus#GO:0006606;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;protein localization to organelle#GO:0033365;intracellular transport#GO:0046907;nuclear transport#GO:0051169;import into nucleus#GO:0051170 envelope#GO:0031975;cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG159767|UniProtKB=T1EPD9 T1EPD9 20198439 PTHR21268:SF2 NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5 NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5 HELRO|EnsemblGenome=HelroG110729|UniProtKB=T1EF46 T1EF46 20195198 PTHR45918:SF1 ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2 ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG143032|UniProtKB=T1EJ87 T1EJ87 20196637 PTHR10828:SF76 M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25 M-PHASE INDUCER PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 regulation of cell cycle G2/M phase transition#GO:1902749;mitotic cell cycle phase transition#GO:0044772;regulation of mitotic cell cycle phase transition#GO:1901990;cell cycle process#GO:0022402;regulation of cell cycle phase transition#GO:1901987;positive regulation of cell cycle#GO:0045787;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047;cell cycle phase transition#GO:0044770;positive regulation of cellular process#GO:0048522;regulation of cell cycle process#GO:0010564;regulation of biological process#GO:0050789;G2/M transition of mitotic cell cycle#GO:0000086;mitotic cell cycle#GO:0000278;regulation of meiotic cell cycle#GO:0051445;regulation of cellular process#GO:0050794;positive regulation of cell cycle process#GO:0090068;positive regulation of mitotic cell cycle#GO:0045931;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of G2/M transition of mitotic cell cycle#GO:0010389;positive regulation of biological process#GO:0048518;regulation of mitotic cell cycle#GO:0007346;cell cycle G2/M phase transition#GO:0044839 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG170108|UniProtKB=T1F2M8 T1F2M8 20203077 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189171|UniProtKB=T1FQR0 T1FQR0 20211157 PTHR10336:SF149 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phospholipase C activity#GO:0004629;phospholipase activity#GO:0004620;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578 lipid metabolic process#GO:0006629;signal transduction#GO:0007165;negative regulation of biological process#GO:0048519;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of sequestering of calcium ion#GO:0051282;regulation of localization#GO:0032879;inorganic ion transmembrane transport#GO:0098660;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;calcium ion transport#GO:0006816;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;glycerolipid metabolic process#GO:0046486;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;intracellular signal transduction#GO:0035556;signaling#GO:0023052;negative regulation of cellular process#GO:0048523;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular response to stimulus#GO:0051716;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;cellular metabolic process#GO:0044237;release of sequestered calcium ion into cytosol#GO:0051209;cell communication#GO:0007154;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;cellular process#GO:0009987;primary metabolic process#GO:0044238;localization#GO:0051179;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;calcium ion transmembrane import into cytosol#GO:0097553;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;organophosphate metabolic process#GO:0019637;monoatomic ion transport#GO:0006811;cellular lipid metabolic process#GO:0044255;negative regulation of sequestering of calcium ion#GO:0051283;monoatomic cation transmembrane transport#GO:0098655 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 phospholipase#PC00186 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PLCbetagamma#P00874;Wnt signaling pathway#P00057>Phospholipase C#P01443;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PLC#P04581;Endothelin signaling pathway#P00019>PLCbeta#P00591;Alpha adrenergic receptor signaling pathway#P00002>PLC#P00073;Oxytocin receptor mediated signaling pathway#P04391>PLC beta#P04530;5HT2 type receptor mediated signaling pathway#P04374>PLC#P04412;Histamine H1 receptor mediated signaling pathway#P04385>PLC#P04484 HELRO|EnsemblGenome=HelroG169800|UniProtKB=T1F2C0 T1F2C0 20202970 PTHR46593:SF1 TRANSMEMBRANE PROTEIN 64 TRANSMEMBRANE PROTEIN 64 inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;chemical homeostasis#GO:0048878;regulation of cytosolic calcium ion concentration#GO:0051480;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;monoatomic ion homeostasis#GO:0050801 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG192189|UniProtKB=T1FTN9 T1FTN9 20212186 PTHR23189:SF45 RNA RECOGNITION MOTIF-CONTAINING RNA-BINDING PROTEIN SPENITO RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG119394|UniProtKB=T1EGN1 T1EGN1 20195731 PTHR11946:SF109 VALYL-TRNA SYNTHETASES VALINE--TRNA LIGASE catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG171867|UniProtKB=T1F4S5 T1F4S5 20203824 PTHR39408:SF3 MUCIN-21 MUCIN-21 HELRO|EnsemblGenome=HelroG171191|UniProtKB=T1F3X1 T1F3X1 20203520 PTHR11920:SF501 GUANYLYL CYCLASE GUANYLATE CYCLASE 32E adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 HELRO|EnsemblGenome=HelroG69964|UniProtKB=T1G006 T1G006 20214404 PTHR22811:SF50 TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 2 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;Golgi organization#GO:0007030;macromolecule localization#GO:0033036;transport#GO:0006810;endomembrane system organization#GO:0010256;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;organelle organization#GO:0006996;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;endoplasmic reticulum#GO:0005783;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG161791|UniProtKB=T1ERX2 T1ERX2 20199322 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG190302|UniProtKB=T1FRV8 T1FRV8 20211555 PTHR12675:SF12 MUSCLEBLIND-LIKE PROTEIN PROTEIN MUSCLEBLIND nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nitrogen compound metabolic process#GO:0051171;regulation of biosynthetic process#GO:0009889;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG88291|UniProtKB=T1G712 T1G712 20216859 PTHR23505:SF79 SPINSTER PROTEIN SPINSTER cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG85596|UniProtKB=T1G602 T1G602 20216499 PTHR24240:SF85 OPSIN OPSIN RH1-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;response to light stimulus#GO:0009416;cellular response to stimulus#GO:0051716;detection of stimulus#GO:0051606;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to external stimulus#GO:0009605;regulation of cellular process#GO:0050794;response to radiation#GO:0009314;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;response to abiotic stimulus#GO:0009628;signaling#GO:0023052;cellular response to light stimulus#GO:0071482 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Rhodopsin#P00747 HELRO|EnsemblGenome=HelroG123705|UniProtKB=T1EGY6 T1EGY6 20195836 PTHR11214:SF314 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE HEXOSYLTRANSFERASE transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG91171|UniProtKB=T1G806 T1G806 20217203 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG175358|UniProtKB=T1F969 T1F969 20205368 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG165615|UniProtKB=T1EX31 T1EX31 20201131 PTHR10544:SF0 60S RIBOSOMAL PROTEIN L28 LARGE RIBOSOMAL SUBUNIT PROTEIN EL28 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG111417|UniProtKB=T1EFB2 T1EFB2 20195264 PTHR43580:SF2 OXIDOREDUCTASE GLYR1-RELATED CYTOKINE-LIKE NUCLEAR FACTOR N-PAC oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG175725|UniProtKB=T1F9K8 T1F9K8 20205507 PTHR18952:SF141 CARBONIC ANHYDRASE CARBONIC ANHYDRASE carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG194428|UniProtKB=T1FW17 T1FW17 20213013 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG177475|UniProtKB=T1FBR4 T1FBR4 20206263 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG160567|UniProtKB=T1EQF5 T1EQF5 20198805 PTHR12483:SF115 SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS COPPER TRANSPORT PROTEIN secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG163101|UniProtKB=T1ETN3 T1ETN3 20199933 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG177751|UniProtKB=T1FC70 T1FC70 20206419 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG88787|UniProtKB=T1G764 T1G764 20216911 PTHR22957:SF657 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN PH DOMAIN-CONTAINING PROTEIN nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;activation of GTPase activity#GO:0090630;biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG169289|UniProtKB=T1F1Q7 T1F1Q7 20202757 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG83783|UniProtKB=T1G5A3 T1G5A3 20216250 PTHR11255:SF80 DIACYLGLYCEROL KINASE EYE-SPECIFIC DIACYLGLYCEROL KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301;lipid kinase activity#GO:0001727 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transferase#PC00220;kinase#PC00137;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG72764|UniProtKB=T1G152 T1G152 20214800 PTHR12820:SF0 VACUOLAR SORTING PROTEIN 53 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG localization#GO:0051179;endosomal transport#GO:0016197;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular process#GO:0009987;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;vesicle tethering complex#GO:0099023;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG156381|UniProtKB=T1ELV0 T1ELV0 20197550 PTHR47507:SF6 BARRIER TO AUTOINTEGRATION FACTOR 2 BARRIER-TO-AUTOINTEGRATION FACTOR nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cellular process#GO:0009987;organelle organization#GO:0006996;chromosome organization#GO:0051276 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;condensed chromosome#GO:0000793;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG113091|UniProtKB=T1EFQ1 T1EFQ1 20195403 PTHR22168:SF3 TMEM26 PROTEIN TRANSMEMBRANE PROTEIN 26 HELRO|EnsemblGenome=HelroG172338|UniProtKB=T1F575 T1F575 20203974 PTHR13055:SF12 TUMOR ENDOTHELIAL MARKER 7 RELATED LD40707P HELRO|EnsemblGenome=HelroG163912|UniProtKB=T1EUM1 T1EUM1 20200271 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171475|UniProtKB=T1F4C1 T1F4C1 20203670 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG96179|UniProtKB=T1G9A5 T1G9A5 20217652 PTHR24031:SF727 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX47-RELATED RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG173825|UniProtKB=T1F7A3 T1F7A3 20204702 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG126731|UniProtKB=T1EHA8 T1EHA8 20195958 PTHR24248:SF199 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR IP13425P-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;regulation of cell communication#GO:0010646;cellular response to stimulus#GO:0051716;regulation of MAPK cascade#GO:0043408;signal transduction#GO:0007165;positive regulation of signal transduction#GO:0009967;regulation of signaling#GO:0023051;cell communication#GO:0007154;cellular process#GO:0009987;regulation of intracellular signal transduction#GO:1902531;positive regulation of MAPK cascade#GO:0043410;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;positive regulation of response to stimulus#GO:0048584;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;positive regulation of cell communication#GO:0010647;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG186418|UniProtKB=T1FNZ4 T1FNZ4 20210541 PTHR15735:SF12 FCH AND DOUBLE SH3 DOMAINS PROTEIN CDC42-INTERACTING PROTEIN 4, ISOFORM B cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG99171|UniProtKB=T1G9R2 T1G9R2 20217808 PTHR11390:SF20 PROKARYOTIC DNA TOPOISOMERASE DNA TOPOISOMERASE 3-BETA-1 catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on DNA#GO:0140097;isomerase activity#GO:0016853;catalytic activity#GO:0003824 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;DNA conformation change#GO:0071103;nucleic acid metabolic process#GO:0090304;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;response to stress#GO:0006950;organelle organization#GO:0006996;chromosome organization#GO:0051276;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG181073|UniProtKB=T1FGK9 T1FGK9 20207958 PTHR32026:SF10 METHYLTRANSFERASE-LIKE PROTEIN 24 METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG183766|UniProtKB=T1FK62 T1FK62 20209211 PTHR10623:SF6 MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER EB1, ISOFORM F-RELATED cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;microtubule plus-end binding#GO:0051010;binding#GO:0005488 regulation of microtubule-based process#GO:0032886;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;macromolecule localization#GO:0033036;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;regulation of cellular component organization#GO:0051128;chromosome segregation#GO:0007059;regulation of biological process#GO:0050789;regulation of cytoskeleton organization#GO:0051493;regulation of microtubule cytoskeleton organization#GO:0070507;spindle assembly#GO:0051225;cytoskeleton organization#GO:0007010;spindle organization#GO:0007051;protein localization to organelle#GO:0033365;non-membrane-bounded organelle assembly#GO:0140694;cellular component assembly#GO:0022607;regulation of organelle organization#GO:0033043;cellular component organization#GO:0016043;regulation of microtubule polymerization or depolymerization#GO:0031110;cellular process#GO:0009987;protein localization#GO:0008104;organelle assembly#GO:0070925;localization#GO:0051179;protein localization to cytoskeleton#GO:0044380;cellular component organization or biogenesis#GO:0071840;cellular macromolecule localization#GO:0070727;microtubule-based process#GO:0007017;regulation of cellular process#GO:0050794;organelle organization#GO:0006996;biological regulation#GO:0065007;cell cycle#GO:0007049 supramolecular complex#GO:0099080;spindle midzone#GO:0051233;microtubule organizing center#GO:0005815;cytoplasmic microtubule#GO:0005881;supramolecular polymer#GO:0099081;cellular anatomical entity#GO:0110165;supramolecular fiber#GO:0099512;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cytoskeleton#GO:0005856;microtubule plus-end#GO:0035371;spindle#GO:0005819;microtubule#GO:0005874 non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG80430|UniProtKB=T1G406 T1G406 20215804 PTHR13460:SF0 FAMILY NOT NAMED MALECTIN cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG66265|UniProtKB=T1FYI8 T1FYI8 20213886 PTHR11537:SF259 VOLTAGE-GATED POTASSIUM CHANNEL KCNQ POTASSIUM CHANNEL, ISOFORM F monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;binding#GO:0005488;calmodulin binding#GO:0005516;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;protein binding#GO:0005515;monoatomic ion channel activity#GO:0005216;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG101065|UniProtKB=T1ED28 T1ED28 20194480 PTHR21646:SF24 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG114251|UniProtKB=T1EG04 T1EG04 20195506 PTHR11363:SF5 60S RIBOSOMAL PROTEIN L3-RELATED LARGE RIBOSOMAL SUBUNIT PROTEIN UL3 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG153314|UniProtKB=T1EL33 T1EL33 20197283 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192579|UniProtKB=T1FU32 T1FU32 20212328 PTHR24115:SF546 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF14 pyrophosphatase activity#GO:0016462;cytoskeletal protein binding#GO:0008092;microtubule motor activity#GO:0003777;tubulin binding#GO:0015631;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;cytoskeletal motor activity#GO:0003774;microtubule binding#GO:0008017;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;microtubule associated complex#GO:0005875;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG135179|UniProtKB=T1EI71 T1EI71 20196271 PTHR15698:SF10 PROTEIN CBG15099 PHYTANOYL-COA HYDROXYLASE-INTERACTING PROTEIN-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194684|UniProtKB=T1FWB3 T1FWB3 20213109 PTHR11360:SF260 MONOCARBOXYLATE TRANSPORTER MFS DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;monocarboxylic acid transmembrane transporter activity#GO:0008028;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;monocarboxylic acid transport#GO:0015718;establishment of localization#GO:0051234;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942 transporter#PC00227 HELRO|EnsemblGenome=HelroG105912|UniProtKB=T1EDY6 T1EDY6 20194788 PTHR10901:SF6 TROPOMODULIN TROPOMODULIN, ISOFORM N cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;binding#GO:0005488 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG191424|UniProtKB=T1FSZ1 T1FSZ1 20211938 PTHR34365:SF7 ENOLASE (DUF1399) GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG179778|UniProtKB=T1FF51 T1FF51 20207450 PTHR14596:SF76 ZINC FINGER PROTEIN DEFECTIVE CHORION PROTEIN, FC177 ISOFORM cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to nutrient levels#GO:0031667;response to extracellular stimulus#GO:0009991;response to stress#GO:0006950;response to starvation#GO:0042594 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG75893|UniProtKB=T1G2C2 T1G2C2 20215220 PTHR11537:SF259 VOLTAGE-GATED POTASSIUM CHANNEL KCNQ POTASSIUM CHANNEL, ISOFORM F monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;binding#GO:0005488;calmodulin binding#GO:0005516;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;protein binding#GO:0005515;monoatomic ion channel activity#GO:0005216;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG132750|UniProtKB=T1EHZ4 T1EHZ4 20196194 PTHR32073:SF7 GH11358P GH11358P HELRO|EnsemblGenome=HelroG170970|UniProtKB=T1F3N1 T1F3N1 20203430 PTHR31996:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 115 COILED-COIL DOMAIN-CONTAINING PROTEIN 115 protein binding#GO:0005515;unfolded protein binding#GO:0051082;binding#GO:0005488 HELRO|EnsemblGenome=HelroG186053|UniProtKB=T1FNL8 T1FNL8 20210415 PTHR48043:SF145 EG:EG0003.4 PROTEIN-RELATED FI06409P-RELATED HELRO|EnsemblGenome=HelroG140634|UniProtKB=T1EJ16 T1EJ16 20196566 PTHR24247:SF222 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE (SEROTONIN) RECEPTOR 2B, ISOFORM E signaling receptor activity#GO:0038023;G protein-coupled amine receptor activity#GO:0008227;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;response to organic cyclic compound#GO:0014070;signal transduction#GO:0007165;cellular response to endogenous stimulus#GO:0071495;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;cellular response to organic substance#GO:0071310;trans-synaptic signaling#GO:0099537;response to organonitrogen compound#GO:0010243;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to nitrogen compound#GO:1901699;response to nitrogen compound#GO:1901698;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to oxygen-containing compound#GO:1901701;response to endogenous stimulus#GO:0009719;chemical synaptic transmission#GO:0007268;response to chemical#GO:0042221;anterograde trans-synaptic signaling#GO:0098916;cellular response to organonitrogen compound#GO:0071417;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;synaptic signaling#GO:0099536;cellular response to organic cyclic compound#GO:0071407;G protein-coupled receptor signaling pathway#GO:0007186;cell-cell signaling#GO:0007267;signaling#GO:0023052 somatodendritic compartment#GO:0036477;neuron projection#GO:0043005;dendrite#GO:0030425;cell periphery#GO:0071944;dendritic tree#GO:0097447;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG162453|UniProtKB=T1ESP2 T1ESP2 20199592 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG93158|UniProtKB=T1G8U2 T1G8U2 20217489 PTHR11787:SF8 RAB GDP-DISSOCIATION INHIBITOR RAB GDP DISSOCIATION INHIBITOR nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;cellular process#GO:0009987;transport#GO:0006810 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG70064|UniProtKB=T1G021 T1G021 20214419 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG159075|UniProtKB=T1ENK0 T1ENK0 20198150 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG97488|UniProtKB=T1G9H3 T1G9H3 20217720 PTHR24253:SF182 TRANSMEMBRANE PROTEASE SERINE PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG110053|UniProtKB=T1EEY8 T1EEY8 20195140 PTHR10887:SF5 DNA2/NAM7 HELICASE FAMILY RNA HELICASE AQUARIUS nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 ribonucleoprotein complex#GO:1990904;catalytic step 2 spliceosome#GO:0071013;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG126387|UniProtKB=T1EH97 T1EH97 20195947 PTHR17453:SF0 SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular component assembly#GO:0022607;localization within membrane#GO:0051668;cotranslational protein targeting to membrane#GO:0006613;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;protein localization to endoplasmic reticulum#GO:0070972;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;protein-containing complex assembly#GO:0065003;protein targeting#GO:0006605;protein targeting to ER#GO:0045047;establishment of protein localization to organelle#GO:0072594;cellular component organization#GO:0016043;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;SRP-dependent cotranslational protein targeting to membrane#GO:0006614;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to membrane#GO:0090150;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein-containing complex organization#GO:0043933;protein localization to organelle#GO:0033365;establishment of protein localization to endoplasmic reticulum#GO:0072599 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG174239|UniProtKB=T1F7V0 T1F7V0 20204899 PTHR46169:SF27 DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A SI:DKEY-13N23.3-RELATED regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG170651|UniProtKB=T1F3A4 T1F3A4 20203303 PTHR16172:SF2 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG67786|UniProtKB=T1FZ52 T1FZ52 20214100 PTHR45888:SF4 HL01030P-RELATED PHD FINGER PROTEIN 10 HELRO|EnsemblGenome=HelroG157477|UniProtKB=T1EMB8 T1EMB8 20197718 PTHR23506:SF13 GH10249P VESICULAR ACETYLCHOLINE TRANSPORTER transmembrane transporter activity#GO:0022857;organic cation transmembrane transporter activity#GO:0015101;transporter activity#GO:0005215 regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;anterograde trans-synaptic signaling#GO:0098916;biological regulation#GO:0065007;trans-synaptic signaling#GO:0099537;synaptic signaling#GO:0099536;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052;cell-cell signaling#GO:0007267 bounding membrane of organelle#GO:0098588;synapse#GO:0045202;intracellular membrane-bounded organelle#GO:0043231;plasma membrane protein complex#GO:0098797;terminal bouton#GO:0043195;clathrin vesicle coat#GO:0030125;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;AP-type membrane coat adaptor complex#GO:0030119;transport vesicle membrane#GO:0030658;clathrin-coated vesicle#GO:0030136;axon terminus#GO:0043679;membrane coat#GO:0030117;neuron projection terminus#GO:0044306;distal axon#GO:0150034;coated membrane#GO:0048475;cytoplasmic vesicle membrane#GO:0030659;cell projection#GO:0042995;trans-Golgi network transport vesicle#GO:0030140;clathrin-coated pit#GO:0005905;membrane protein complex#GO:0098796;presynapse#GO:0098793;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;cell junction#GO:0030054;cell periphery#GO:0071944;coated vesicle#GO:0030135;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;vesicle coat#GO:0030120;axon#GO:0030424;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;Golgi-associated vesicle membrane#GO:0030660;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;coated vesicle membrane#GO:0030662;neuron projection#GO:0043005;Golgi-associated vesicle#GO:0005798;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;endocytic vesicle#GO:0030139;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>VAChT#P01078;Nicotinic acetylcholine receptor signaling pathway#P00044>VAChT#P01089;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>VAChT#P01065 HELRO|EnsemblGenome=HelroG194759|UniProtKB=T1FWD7 T1FWD7 20213132 PTHR11969:SF99 MAX DIMERIZATION, MAD MAX-BINDING PROTEIN MNT sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG180252|UniProtKB=T1FFN0 T1FFN0 20207629 PTHR21588:SF18 COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 6 MICOS COMPLEX SUBUNIT MIC19 cellular component organization or biogenesis#GO:0071840;membrane organization#GO:0061024;organelle organization#GO:0006996;cellular component organization#GO:0016043;mitochondrial membrane organization#GO:0007006;mitochondrion organization#GO:0007005;cellular process#GO:0009987;inner mitochondrial membrane organization#GO:0007007 envelope#GO:0031975;membrane protein complex#GO:0098796;mitochondrial membrane#GO:0031966;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;organelle inner membrane#GO:0019866;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;inner mitochondrial membrane protein complex#GO:0098800;membrane-bounded organelle#GO:0043227;mitochondrial protein-containing complex#GO:0098798 HELRO|EnsemblGenome=HelroG182344|UniProtKB=T1FI34 T1FI34 20208483 PTHR24345:SF91 SERINE/THREONINE-PROTEIN KINASE PLK SERINE_THREONINE-PROTEIN KINASE PLK4 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG64675|UniProtKB=T1FXX9 T1FXX9 20213677 PTHR23292:SF6 LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR FI16602P1-RELATED cation binding#GO:0043169;metal ion binding#GO:0046872;ion binding#GO:0043167;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;binding#GO:0005488;transition metal ion binding#GO:0046914 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG101473|UniProtKB=T1ED49 T1ED49 20194501 PTHR19876:SF1 COATOMER COATOMER SUBUNIT ALPHA endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;intra-Golgi vesicle-mediated transport#GO:0006891;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;vesicle coat#GO:0030120;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;Golgi-associated vesicle membrane#GO:0030660;protein-containing complex#GO:0032991;COPI vesicle coat#GO:0030126;endomembrane system#GO:0012505;membrane coat#GO:0030117;coated vesicle membrane#GO:0030662;COPI-coated vesicle#GO:0030137;Golgi-associated vesicle#GO:0005798;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;coated membrane#GO:0048475;cytoplasmic vesicle membrane#GO:0030659 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG165981|UniProtKB=T1EXJ1 T1EXJ1 20201291 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182651|UniProtKB=T1FIJ4 T1FIJ4 20208643 PTHR10649:SF12 ARYL HYDROCARBON RECEPTOR SPINELESS, ISOFORM C sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;molecular transducer activity#GO:0060089;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG190667|UniProtKB=T1FS70 T1FS70 20211667 PTHR19890:SF10 FIBROBLAST GROWTH FACTOR RECEPTOR FIBROBLAST GROWTH FACTOR RECEPTOR-LIKE 1 transmembrane signal receptor#PC00197;tyrosine protein kinase receptor#PC00233 HELRO|EnsemblGenome=HelroG66158|UniProtKB=T1FYH6 T1FYH6 20213874 PTHR10652:SF0 ADENYLYL CYCLASE-ASSOCIATED PROTEIN ADENYLYL CYCLASE-ASSOCIATED PROTEIN cytoskeletal protein binding#GO:0008092;enzyme binding#GO:0019899;protein binding#GO:0005515;actin binding#GO:0003779;binding#GO:0005488 signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;actin filament-based process#GO:0030029;regulation of cellular process#GO:0050794;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;biological regulation#GO:0065007;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;intracellular signaling cassette#GO:0141124;intracellular signal transduction#GO:0035556;actin cytoskeleton organization#GO:0030036;signaling#GO:0023052;cAMP-mediated signaling#GO:0019933;cyclic-nucleotide-mediated signaling#GO:0019935 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG182785|UniProtKB=T1FIQ4 T1FIQ4 20208703 PTHR20963:SF8 MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE 1 hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG85865|UniProtKB=T1G636 T1G636 20216533 PTHR11819:SF150 SOLUTE CARRIER FAMILY 5 SODIUM_MYO-INOSITOL COTRANSPORTER inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;carbohydrate transmembrane transporter activity#GO:0015144;symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;sugar transmembrane transporter activity#GO:0051119;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;monoatomic ion transmembrane transporter activity#GO:0015075;inorganic cation transmembrane transporter activity#GO:0022890;solute:monoatomic cation symporter activity#GO:0015294 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG107544|UniProtKB=T1EEB1 T1EEB1 20194913 PTHR43721:SF9 ELONGATION FACTOR TU-RELATED GTP-BINDING PROTEIN 1 nucleic acid binding#GO:0003676;translation regulator activity#GO:0045182;translation regulator activity, nucleic acid binding#GO:0090079;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation elongation factor activity#GO:0003746;translation factor activity, RNA binding#GO:0008135 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;translational elongation#GO:0006414;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 translation elongation factor#PC00222;translational protein#PC00263 HELRO|EnsemblGenome=HelroG166204|UniProtKB=T1EXW6 T1EXW6 20201416 PTHR16231:SF0 COMM DOMAIN-CONTAINING PROTEIN 4-8 FAMILY MEMBER COMM DOMAIN-CONTAINING PROTEIN 8 HELRO|EnsemblGenome=HelroG162936|UniProtKB=T1ETD8 T1ETD8 20199838 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG73641|UniProtKB=T1G1G7 T1G1G7 20214915 PTHR45817:SF4 LYSYL OXIDASE-LIKE-RELATED LYSYL OXIDASE-LIKE-RELATED catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 oxidase#PC00175;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG166882|UniProtKB=T1EYP7 T1EYP7 20201697 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG67136|UniProtKB=T1FYX2 T1FYX2 20214020 PTHR23245:SF25 TRNA METHYLTRANSFERASE TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 2 HOMOLOG tRNA methyltransferase activity#GO:0008175;catalytic activity, acting on RNA#GO:0140098;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;RNA methyltransferase activity#GO:0008173 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;carbohydrate derivative metabolic process#GO:1901135;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;ncRNA metabolic process#GO:0034660;tRNA methylation#GO:0030488;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nucleic acid metabolic process#GO:0090304;methylation#GO:0032259;macromolecule methylation#GO:0043414;RNA methylation#GO:0001510;glycosyl compound metabolic process#GO:1901657 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG185597|UniProtKB=T1FN06 T1FN06 20210205 PTHR10926:SF0 CELL CYCLE CONTROL PROTEIN 50 CDC50, ISOFORM A cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG170716|UniProtKB=T1F3C6 T1F3C6 20203325 PTHR31872:SF4 TRANSMEMBRANE PROTEIN 179 TRANSMEMBRANE PROTEIN 179 HELRO|EnsemblGenome=HelroG112809|UniProtKB=T1EFM3 T1EFM3 20195375 PTHR11785:SF531 AMINO ACID TRANSPORTER LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 1 L-amino acid transmembrane transporter activity#GO:0015179;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;amino acid transport#GO:0006865;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;nitrogen compound transport#GO:0071705;organic acid transmembrane transport#GO:1903825;carboxylic acid transport#GO:0046942;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039 transporter#PC00227 HELRO|EnsemblGenome=HelroG190270|UniProtKB=T1FRU4 T1FRU4 20211541 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG164040|UniProtKB=T1EUT3 T1EUT3 20200333 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184267|UniProtKB=T1FKV8 T1FKV8 20209457 PTHR19963:SF30 CCHC-TYPE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG90057|UniProtKB=T1G7K4 T1G7K4 20217051 PTHR24064:SF577 SOLUTE CARRIER FAMILY 22 MEMBER GH09241P secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG182842|UniProtKB=T1FIU6 T1FIU6 20208745 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174039|UniProtKB=T1F7I4 T1F7I4 20204783 PTHR22950:SF652 AMINO ACID TRANSPORTER TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN L-amino acid transmembrane transporter activity#GO:0015179;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;amino acid transport#GO:0006865;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;nitrogen compound transport#GO:0071705;organic acid transmembrane transport#GO:1903825;carboxylic acid transport#GO:0046942;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039 cellular anatomical entity#GO:0110165;membrane#GO:0016020 amino acid transporter#PC00046;transporter#PC00227 HELRO|EnsemblGenome=HelroG64794|UniProtKB=T1FXZ4 T1FXZ4 20213692 PTHR24033:SF218 EGF-LIKE DOMAIN-CONTAINING PROTEIN EGF-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG74778|UniProtKB=T1G1V4 T1G1V4 20215052 PTHR45881:SF6 CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED FORK-HEAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168913|UniProtKB=T1F145 T1F145 20202545 PTHR11571:SF230 GLUTATHIONE S-TRANSFERASE GLUTATHIONE TRANSFERASE glutathione transferase activity#GO:0004364;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824 sulfur compound metabolic process#GO:0006790;nitrogen compound metabolic process#GO:0006807;peptide metabolic process#GO:0006518;cellular modified amino acid metabolic process#GO:0006575;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular process#GO:0009987;glutathione metabolic process#GO:0006749;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG163804|UniProtKB=T1EUH6 T1EUH6 20200226 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG167244|UniProtKB=T1EZ61 T1EZ61 20201861 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG180025|UniProtKB=T1FFD0 T1FFD0 20207529 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG188640|UniProtKB=T1FQ75 T1FQ75 20210972 PTHR21625:SF1 NYD-SP28 PROTEIN DYNEIN REGULATORY COMPLEX PROTEIN 1 regulation of microtubule-based process#GO:0032886;cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;microtubule cytoskeleton organization#GO:0000226;cilium or flagellum-dependent cell motility#GO:0001539;protein-containing complex assembly#GO:0065003;cell motility#GO:0048870;cellular component organization#GO:0016043;axoneme assembly#GO:0035082;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;regulation of biological process#GO:0050789;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cilium-dependent cell motility#GO:0060285;microtubule-based process#GO:0007017;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection assembly#GO:0120031 axoneme#GO:0005930;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;plasma membrane bounded cell projection cytoplasm#GO:0032838;membrane-bounded organelle#GO:0043227;ciliary plasm#GO:0097014;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929 HELRO|EnsemblGenome=HelroG71441|UniProtKB=T1G0L8 T1G0L8 20214616 PTHR47992:SF150 PROTEIN PHOSPHATASE PROTEIN PHOSPHATASE 1D hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;dephosphorylation#GO:0016311;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein phosphatase#PC00195;protein modifying enzyme#PC00260 p53 pathway feedback loops 2#P04398>WIP-1#P04650;p53 pathway#P00059>WIP-1#G04693;p53 pathway feedback loops 2#P04398>WIP-1#G04708 HELRO|EnsemblGenome=HelroG87424|UniProtKB=T1G6P8 T1G6P8 20216745 PTHR24322:SF736 PKSB RETINOL DEHYDROGENASE 10 oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG81245|UniProtKB=T1G4C1 T1G4C1 20215919 PTHR31792:SF3 VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21 VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21 protein-containing complex assembly#GO:0065003;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cellular process#GO:0009987;protein-containing complex organization#GO:0043933 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG193739|UniProtKB=T1FVB0 T1FVB0 20212756 PTHR13455:SF7 TRANSCRIPTIONAL REPRESSOR P66-RELATED SIMJANG, ISOFORM E negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;chromosome#GO:0005694;histone deacetylase complex#GO:0000118;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG185589|UniProtKB=T1FN04 T1FN04 20210203 PTHR13266:SF1 PROTEASOME INHIBITOR PROTEASOME INHIBITOR PI31 SUBUNIT macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG68721|UniProtKB=T1FZI8 T1FZI8 20214236 PTHR10285:SF70 URIDINE KINASE URIDINE KINASE cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 nucleotide kinase#PC00172 Salvage pyrimidine ribonucleotides#P02775>Uridine kinase#P03150;Salvage pyrimidine ribonucleotides#P02775>Cytidine kinase#P03149;Salvage pyrimidine ribonucleotides#P02775>CDP kinase#P03156 HELRO|EnsemblGenome=HelroG128637|UniProtKB=T1EHP5 T1EHP5 20196095 PTHR23430:SF50 HISTONE H2A HISTONE H2A.1-RELATED nucleosome binding#GO:0031491;nucleic acid binding#GO:0003676;chromatin DNA binding#GO:0031490;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;protein-containing complex binding#GO:0044877 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;protein-DNA complex organization#GO:0071824;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;heterochromatin formation#GO:0031507;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;negative regulation of gene expression, epigenetic#GO:0045814;cellular process#GO:0009987;epigenetic regulation of gene expression#GO:0040029;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;heterochromatin organization#GO:0070828;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG194432|UniProtKB=T1FW18 T1FW18 20213014 PTHR10242:SF2 8-OXOGUANINE DNA GLYCOSYLASE N-GLYCOSYLASE_DNA LYASE DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG194041|UniProtKB=T1FVL6 T1FVL6 20212862 PTHR12460:SF0 CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN CID DOMAIN-CONTAINING PROTEIN-RELATED basal RNA polymerase II transcription machinery binding#GO:0001099;RNA polymerase binding#GO:0070063;binding#GO:0005488;RNA polymerase core enzyme binding#GO:0043175;RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515;enzyme binding#GO:0019899;basal transcription machinery binding#GO:0001098 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;mRNA 3'-end processing#GO:0031124;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mRNA processing#GO:0006397;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 kinase modulator#PC00140;kinase inhibitor#PC00139 HELRO|EnsemblGenome=HelroG165385|UniProtKB=T1EWP5 T1EWP5 20200995 PTHR46880:SF5 RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG190637|UniProtKB=T1FS58 T1FS58 20211655 PTHR13025:SF6 EF-HAND DOMAIN-CONTAINING PROTEIN D EF-HAND DOMAIN-CONTAINING PROTEIN-RELATED cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG176546|UniProtKB=T1FAM9 T1FAM9 20205878 PTHR33332:SF48 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164378|UniProtKB=T1EVC6 T1EVC6 20200526 PTHR31508:SF2 PROTEIN PITCHFORK PROTEIN PITCHFORK cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;binding#GO:0005488 biological regulation#GO:0065007;regulation of biological process#GO:0050789;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of cell projection organization#GO:0031344 HELRO|EnsemblGenome=HelroG163668|UniProtKB=T1EUC2 T1EUC2 20200172 PTHR43048:SF3 METHYLMALONYL-COA EPIMERASE METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL isomerase activity#GO:0016853;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;carbohydrate derivative metabolic process#GO:1901135;sulfur compound metabolic process#GO:0006790;acyl-CoA metabolic process#GO:0006637;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;phosphate-containing compound metabolic process#GO:0006796;primary metabolic process#GO:0044238;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;amide metabolic process#GO:0043603;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 epimerase/racemase#PC00096 Methylmalonyl pathway#P02755>Methylmalonyl-CoA epimerase#P03032 HELRO|EnsemblGenome=HelroG164275|UniProtKB=T1EV70 T1EV70 20200470 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164805|UniProtKB=T1EVU0 T1EVU0 20200690 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED BRCT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG93198|UniProtKB=T1G8U3 T1G8U3 20217490 PTHR46042:SF1 DIPHTHINE METHYLTRANSFERASE DIPHTHINE METHYLTRANSFERASE hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG93760|UniProtKB=T1G8X6 T1G8X6 20217523 PTHR13812:SF19 KETIMINE REDUCTASE MU-CRYSTALLIN KETIMINE REDUCTASE MU-CRYSTALLIN reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG190537|UniProtKB=T1FS30 T1FS30 20211627 PTHR12107:SF0 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT STARGAZIN (MAMMALIAN CALCIUM CHANNEL) HOMOLOG calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;voltage-gated channel activity#GO:0022832;molecular function regulator activity#GO:0098772;transporter regulator activity#GO:0141108;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;channel regulator activity#GO:0016247;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;inorganic cation transmembrane transporter activity#GO:0022890 cellular localization#GO:0051641;macromolecule localization#GO:0033036;receptor internalization#GO:0031623;system process#GO:0003008;transport#GO:0006810;regulation of signaling#GO:0023051;nitrogen compound transport#GO:0071705;regulation of localization#GO:0032879;endosome to lysosome transport#GO:0008333;lysosomal transport#GO:0007041;establishment of protein localization#GO:0045184;regulation of biological process#GO:0050789;organic substance transport#GO:0071702;regulation of transport#GO:0051049;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;regulation of molecular function#GO:0065009;regulation of signal transduction#GO:0009966;receptor-mediated endocytosis#GO:0006898;regulation of monoatomic ion transmembrane transporter activity#GO:0032412;regulation of transmembrane transporter activity#GO:0022898;protein localization to organelle#GO:0033365;regulation of transporter activity#GO:0032409;positive regulation of signaling#GO:0023056;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;positive regulation of biological process#GO:0048518;localization within membrane#GO:0051668;regulation of cell communication#GO:0010646;establishment of protein localization to vacuole#GO:0072666;regulation of transmembrane transport#GO:0034762;vacuolar transport#GO:0007034;endocytosis#GO:0006897;protein localization to vacuole#GO:0072665;vesicle-mediated transport#GO:0016192;establishment of protein localization to organelle#GO:0072594;nervous system process#GO:0050877;cell communication#GO:0007154;cellular process#GO:0009987;regulation of synaptic transmission, glutamatergic#GO:0051966;protein localization#GO:0008104;positive regulation of cellular process#GO:0048522;localization#GO:0051179;regulation of response to stimulus#GO:0048583;protein localization to lysosome#GO:0061462;cellular macromolecule localization#GO:0070727;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;positive regulation of cell communication#GO:0010647;protein transport#GO:0015031;biological regulation#GO:0065007;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;regulation of trans-synaptic signaling#GO:0099177;multicellular organismal process#GO:0032501;intracellular transport#GO:0046907;positive regulation of synaptic transmission#GO:0050806;import into cell#GO:0098657;protein-containing complex localization#GO:0031503 membrane protein complex#GO:0098796;synapse#GO:0045202;postsynaptic specialization#GO:0099572;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;plasma membrane signaling receptor complex#GO:0098802;transporter complex#GO:1990351;plasma membrane protein complex#GO:0098797;cell junction#GO:0030054;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;neuron to neuron synapse#GO:0098984;membrane#GO:0016020;synaptic membrane#GO:0097060;asymmetric synapse#GO:0032279;receptor complex#GO:0043235;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;transmembrane transporter complex#GO:1902495;postsynaptic density membrane#GO:0098839;postsynaptic specialization membrane#GO:0099634;plasma membrane region#GO:0098590;postsynapse#GO:0098794;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG91097|UniProtKB=T1G7Z8 T1G7Z8 20217195 PTHR24247:SF238 5-HYDROXYTRYPTAMINE RECEPTOR DOPAMINE RECEPTOR 1 signaling receptor activity#GO:0038023;G protein-coupled amine receptor activity#GO:0008227;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission#GO:0007268;regulation of cellular process#GO:0050794;synaptic signaling#GO:0099536;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;cell-cell signaling#GO:0007267 somatodendritic compartment#GO:0036477;neuron projection#GO:0043005;dendrite#GO:0030425;cell periphery#GO:0071944;dendritic tree#GO:0097447;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Dopamine receptor mediated signaling pathway#P05912>D1/D5#P05948 HELRO|EnsemblGenome=HelroG63797|UniProtKB=T1FXK3 T1FXK3 20213551 PTHR43097:SF4 GLUTAMINE-TRNA LIGASE GLUTAMINE--TRNA LIGASE catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 Heme biosynthesis#P02746>Glutamyl-tRNA-synthetase#P02977 HELRO|EnsemblGenome=HelroG174976|UniProtKB=T1F8N9 T1F8N9 20205188 PTHR22805:SF2 WDR41-RELATED WD REPEAT-CONTAINING PROTEIN 41 HELRO|EnsemblGenome=HelroG194836|UniProtKB=T1FWG9 T1FWG9 20213164 PTHR47160:SF5 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194517|UniProtKB=T1FW54 T1FW54 20213050 PTHR11905:SF159 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM METALLOPROTEASE metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG112541|UniProtKB=T1EFK6 T1EFK6 20195358 PTHR45735:SF2 CLEAVAGE STIMULATION FACTOR SUBUNIT 2 CLEAVAGE STIMULATION FACTOR SUBUNIT 2 nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;mRNA cleavage factor complex#GO:0005849;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG97753|UniProtKB=T1G9I8 T1G9I8 20217735 PTHR10603:SF7 FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN FRAGILE X MESSENGER RIBONUCLEOPROTEIN 1 HOMOLOG RNA binding#GO:0003723;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159;mRNA 3'-UTR binding#GO:0003730 positive regulation of gene expression#GO:0010628;positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;regulation of mRNA stability#GO:0043488;regulation of mRNA catabolic process#GO:0061013;regulation of catabolic process#GO:0009894;macromolecule localization#GO:0033036;regulation of nitrogen compound metabolic process#GO:0051171;animal organ development#GO:0048513;positive regulation of cellular metabolic process#GO:0031325;transport#GO:0006810;developmental process#GO:0032502;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;RNA localization#GO:0006403;regulation of biological process#GO:0050789;organic substance transport#GO:0071702;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;RNA transport#GO:0050658;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;positive regulation of translation#GO:0045727;establishment of RNA localization#GO:0051236;positive regulation of cellular biosynthetic process#GO:0031328;regulation of cellular catabolic process#GO:0031329;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;mRNA transport#GO:0051028;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;localization#GO:0051179;regulation of primary metabolic process#GO:0080090;positive regulation of protein metabolic process#GO:0051247;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleobase-containing compound transport#GO:0015931;post-transcriptional regulation of gene expression#GO:0010608;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of metabolic process#GO:0019222;regulation of mRNA metabolic process#GO:1903311;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytoplasmic stress granule#GO:0010494;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic ribonucleoprotein granule#GO:0036464 translation factor#PC00223 HELRO|EnsemblGenome=HelroG88449|UniProtKB=T1G727 T1G727 20216874 PTHR24044:SF417 NOTCH LIGAND FAMILY MEMBER WEARY, ISOFORM B protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG158265|UniProtKB=T1EML3 T1EML3 20197813 PTHR19376:SF37 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;RNA polymerase activity#GO:0097747;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;RNA polymerase II activity#GO:0001055 membrane-enclosed lumen#GO:0031974;RNA polymerase II, core complex#GO:0005665;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase II, holoenzyme#GO:0016591;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG107834|UniProtKB=T1EED2 T1EED2 20194934 PTHR45736:SF1 ZINC FINGER MYM-TYPE PROTEIN WITHOUT CHILDREN, ISOFORM B zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG193150|UniProtKB=T1FUN8 T1FUN8 20212534 PTHR10098:SF108 RAPSYN-RELATED TETRATRICOPEPTIDE REPEAT PROTEIN 28 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG77074|UniProtKB=T1G2T0 T1G2T0 20215378 PTHR31233:SF6 BICAUDAL D FAMILY MEMBER PROTEIN BICAUDAL D cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;dynein complex binding#GO:0070840 regulation of microtubule-based process#GO:0032886;cellular localization#GO:0051641;macromolecule localization#GO:0033036;regulation of organelle organization#GO:0033043;microtubule cytoskeleton organization#GO:0000226;regulation of cellular component organization#GO:0051128;cellular component organization#GO:0016043;cellular process#GO:0009987;protein localization#GO:0008104;localization#GO:0051179;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cytoskeleton organization#GO:0051493;cellular macromolecule localization#GO:0070727;microtubule-based process#GO:0007017;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;regulation of microtubule cytoskeleton organization#GO:0070507;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;protein localization to organelle#GO:0033365 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG63383|UniProtKB=T1FXF1 T1FXF1 20213499 PTHR13624:SF6 RE42071P EMEI HELRO|EnsemblGenome=HelroG186161|UniProtKB=T1FNR0 T1FNR0 20210457 PTHR13403:SF6 SNURPORTIN1 RNUT1 PROTEIN RNA, U TRANSPORTER 1 SNURPORTIN-1 transporter#PC00227 HELRO|EnsemblGenome=HelroG178121|UniProtKB=T1FCS1 T1FCS1 20206620 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG87604|UniProtKB=T1G6S8 T1G6S8 20216775 PTHR11006:SF53 PROTEIN ARGININE N-METHYLTRANSFERASE PROTEIN ARGININE N-METHYLTRANSFERASE 3 N-methyltransferase activity#GO:0008170;histone modifying activity#GO:0140993;transferase activity#GO:0016740;catalytic activity#GO:0003824;histone methyltransferase activity#GO:0042054;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a protein#GO:0140096;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein methyltransferase activity#GO:0008276 protein-DNA complex organization#GO:0071824;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;cellular component organization#GO:0016043;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;methylation#GO:0032259;macromolecule methylation#GO:0043414;nitrogen compound metabolic process#GO:0006807;protein-containing complex organization#GO:0043933;chromatin organization#GO:0006325;protein metabolic process#GO:0019538;chromatin remodeling#GO:0006338;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG172168|UniProtKB=T1F538 T1F538 20203937 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG90358|UniProtKB=T1G7P6 T1G7P6 20217093 PTHR24189:SF50 MYOTROPHIN ANKYRIN REPEAT AND SOCS BOX PROTEIN 2 HELRO|EnsemblGenome=HelroG176405|UniProtKB=T1FAH6 T1FAH6 20205825 PTHR31159:SF1 COMM DOMAIN-CONTAINING PROTEIN 3 COMM DOMAIN-CONTAINING PROTEIN 3 HELRO|EnsemblGenome=HelroG194731|UniProtKB=T1FWC9 T1FWC9 20213124 PTHR14453:SF67 PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN POLY [ADP-RIBOSE] POLYMERASE molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;protein-macromolecule adaptor activity#GO:0030674 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG103432|UniProtKB=T1EDG1 T1EDG1 20194613 PTHR11060:SF0 PROTEIN MEMO1 PROTEIN MEMO1 HELRO|EnsemblGenome=HelroG168825|UniProtKB=T1F105 T1F105 20202505 PTHR11360:SF260 MONOCARBOXYLATE TRANSPORTER MFS DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;monocarboxylic acid transmembrane transporter activity#GO:0008028;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;monocarboxylic acid transport#GO:0015718;establishment of localization#GO:0051234;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942 transporter#PC00227 HELRO|EnsemblGenome=HelroG81117|UniProtKB=T1G496 T1G496 20215894 PTHR13168:SF0 ASSOCIATE OF C-MYC AMY-1 C-MYC-BINDING PROTEIN transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;protein-macromolecule adaptor activity#GO:0030674 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transcription cofactor#PC00217 PDGF signaling pathway#P00047>c-Myc#P01172 HELRO|EnsemblGenome=HelroG159371|UniProtKB=T1ENY6 T1ENY6 20198286 PTHR24241:SF193 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;binding#GO:0005488;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888;amide binding#GO:0033218 response to organic substance#GO:0010033;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;response to hormone#GO:0009725;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG95386|UniProtKB=T1G955 T1G955 20217602 PTHR10218:SF362 GTP-BINDING PROTEIN ALPHA SUBUNIT G PROTEIN ALPHA O SUBUNIT GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;ribonucleoside triphosphate phosphatase activity#GO:0017111;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 regulation of biological process#GO:0050789;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;side of membrane#GO:0098552;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;extrinsic component of membrane#GO:0019898 heterotrimeric G-protein#PC00117;G-protein#PC00020 Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Enkephalin release#P05913>G-Protein (i)#P05974;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;Opioid prodynorphin pathway#P05916>G-protein#P06002;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047 HELRO|EnsemblGenome=HelroG74931|UniProtKB=T1G1Y0 T1G1Y0 20215078 PTHR21451:SF0 HISTONE H3 METHYLTRANSFERASE HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC N-methyltransferase activity#GO:0008170;histone modifying activity#GO:0140993;transferase activity#GO:0016740;catalytic activity#GO:0003824;histone methyltransferase activity#GO:0042054;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;protein-lysine N-methyltransferase activity#GO:0016279;catalytic activity, acting on a protein#GO:0140096;lysine N-methyltransferase activity#GO:0016278;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein methyltransferase activity#GO:0008276 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;signal transduction#GO:0007165;negative regulation of biological process#GO:0048519;DNA damage checkpoint signaling#GO:0000077;negative regulation of cell cycle process#GO:0010948;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;cell cycle checkpoint signaling#GO:0000075;DNA damage response#GO:0006974;organic cyclic compound metabolic process#GO:1901360;regulation of molecular function#GO:0065009;nitrogen compound metabolic process#GO:0006807;signal transduction in response to DNA damage#GO:0042770;intracellular signal transduction#GO:0035556;signaling#GO:0023052;negative regulation of cellular process#GO:0048523;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;negative regulation of cell cycle#GO:0045786;macromolecule metabolic process#GO:0043170;negative regulation of cell cycle phase transition#GO:1901988;regulation of cell cycle phase transition#GO:1901987;cellular metabolic process#GO:0044237;cell communication#GO:0007154;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;regulation of cell cycle process#GO:0010564;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;DNA integrity checkpoint signaling#GO:0031570;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG173773|UniProtKB=T1F777 T1F777 20204676 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG104891|UniProtKB=T1EDP1 T1EDP1 20194693 PTHR45745:SF1 PHOSPHOMANNOMUTASE 45A PHOSPHOGLUCOMUTASE 2B-RELATED isomerase activity#GO:0016853;intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;nucleoside metabolic process#GO:0009116;carbohydrate derivative metabolic process#GO:1901135;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;purine-containing compound biosynthetic process#GO:0072522;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;organic cyclic compound metabolic process#GO:1901360;nucleobase-containing compound biosynthetic process#GO:0034654;purine nucleoside metabolic process#GO:0042278;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;purine-containing compound metabolic process#GO:0072521;aromatic compound biosynthetic process#GO:0019438;small molecule biosynthetic process#GO:0044283;glycosyl compound metabolic process#GO:1901657;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;nucleobase-containing small molecule metabolic process#GO:0055086 mutase#PC00160 HELRO|EnsemblGenome=HelroG108278|UniProtKB=T1EEI0 T1EEI0 20194982 PTHR15316:SF1 SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED SPLICING FACTOR 3A SUBUNIT 1 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of mRNA processing#GO:0050684;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of metabolic process#GO:0019222;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;regulation of cellular metabolic process#GO:0031323;regulation of mRNA metabolic process#GO:1903311 catalytic step 2 spliceosome#GO:0071013;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;U2-type spliceosomal complex#GO:0005684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;U2 snRNP#GO:0005686;U2-type prespliceosome#GO:0071004;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG113207|UniProtKB=T1EFQ8 T1EFQ8 20195410 PTHR43205:SF7 PROSTAGLANDIN REDUCTASE PROSTAGLANDIN REDUCTASE 1 reductase#PC00198;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG164974|UniProtKB=T1EW18 T1EW18 20200768 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG153281|UniProtKB=T1EL25 T1EL25 20197275 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG81901|UniProtKB=T1G4K5 T1G4K5 20216003 PTHR11675:SF131 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 9-RELATED transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG185197|UniProtKB=T1FMH8 T1FMH8 20210027 PTHR12489:SF1 LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN LP10272P cellular anatomical entity#GO:0110165;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG185861|UniProtKB=T1FND2 T1FND2 20210329 PTHR14063:SF2 PROTEIN LIN-7 HOMOLOG PROTEIN LIN-7 HOMOLOG establishment or maintenance of cell polarity#GO:0007163;cellular localization#GO:0051641;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;macromolecule localization#GO:0033036;transport#GO:0006810;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;secretion#GO:0046903;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;signal release#GO:0023061;establishment or maintenance of apical/basal cell polarity#GO:0035088;cell-cell signaling#GO:0007267;signaling#GO:0023052;secretion by cell#GO:0032940;neurotransmitter secretion#GO:0007269;localization within membrane#GO:0051668;protein localization to membrane#GO:0072657;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;protein localization#GO:0008104;protein localization to cell periphery#GO:1990778;localization#GO:0051179;cellular macromolecule localization#GO:0070727;signal release from synapse#GO:0099643;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;establishment or maintenance of bipolar cell polarity#GO:0061245;export from cell#GO:0140352 basal plasma membrane#GO:0009925;synapse#GO:0045202;anchoring junction#GO:0070161;cell-cell junction#GO:0005911;basolateral plasma membrane#GO:0016323;cell junction#GO:0030054;plasma membrane region#GO:0098590;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;basal part of cell#GO:0045178;membrane#GO:0016020;plasma membrane#GO:0005886 cell junction protein#PC00070 HELRO|EnsemblGenome=HelroG182048|UniProtKB=T1FHN2 T1FHN2 20208331 PTHR45784:SF5 C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED HELRO|EnsemblGenome=HelroG113770|UniProtKB=T1EFW2 T1EFW2 20195464 PTHR45702:SF2 ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER KUZBANIAN, ISOFORM A hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 membrane protein proteolysis#GO:0033619;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;membrane protein ectodomain proteolysis#GO:0006509;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-amyloid secretase pathway#P00003>ADAM10#P00108 HELRO|EnsemblGenome=HelroG190288|UniProtKB=T1FRV2 T1FRV2 20211549 PTHR13723:SF306 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG158463|UniProtKB=T1EMT7 T1EMT7 20197887 PTHR46150:SF3 RHO GTPASE-ACTIVATING PROTEIN 100F RHO GTPASE-ACTIVATING PROTEIN 100F nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;regulation of signaling#GO:0023051;biological regulation#GO:0065007;cell motility#GO:0048870;cellular process#GO:0009987;cell migration#GO:0016477;regulation of intracellular signal transduction#GO:1902531;regulation of small GTPase mediated signal transduction#GO:0051056 synapse#GO:0045202;cell junction#GO:0030054;plasma membrane region#GO:0098590;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;synaptic membrane#GO:0097060;plasma membrane#GO:0005886 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG174654|UniProtKB=T1F8C7 T1F8C7 20205076 PTHR10288:SF171 KH DOMAIN CONTAINING RNA BINDING PROTEIN P-ELEMENT SOMATIC INHIBITOR, ISOFORM C nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG177374|UniProtKB=T1FBL1 T1FBL1 20206210 PTHR12027:SF77 WNT RELATED PROTEIN WNT-5 molecular function activator activity#GO:0140677;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;protein binding#GO:0005515;cytokine activity#GO:0005125;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;neurogenesis#GO:0022008;developmental process#GO:0032502;multicellular organism development#GO:0007275;cell communication#GO:0007154;cell fate commitment#GO:0045165;cell-cell signaling by wnt#GO:0198738;nervous system development#GO:0007399;cellular process#GO:0009987;regulation of biological process#GO:0050789;system development#GO:0048731;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;cell-cell signaling#GO:0007267;signaling#GO:0023052;canonical Wnt signaling pathway#GO:0060070;Wnt signaling pathway#GO:0016055 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Angiogenesis#P00005>Wnt#P00206;Cadherin signaling pathway#P00012>Wnt#P00474 HELRO|EnsemblGenome=HelroG108467|UniProtKB=T1EEJ4 T1EEJ4 20194996 PTHR11635:SF152 CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 kinase modulator#PC00140 Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Cell cycle#P00013>Protein kinase subunit#P00482;GABA-B receptor II signaling#P05731>PKA#P05752;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Enkephalin release#P05913>PKA#P05972;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Transcription regulation by bZIP transcription factor#P00055>PKA#P01384;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Hedgehog signaling pathway#P00025>PKA#P00682;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059;Endothelin signaling pathway#P00019>PKA#P00570 HELRO|EnsemblGenome=HelroG170858|UniProtKB=T1F3I7 T1F3I7 20203386 PTHR42264:SF6 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE PROTEIN HELRO|EnsemblGenome=HelroG179816|UniProtKB=T1FF66 T1FF66 20207465 PTHR15315:SF64 RING FINGER PROTEIN 41, 151 RING FINGER PROTEIN 151 HELRO|EnsemblGenome=HelroG191655|UniProtKB=T1FT65 T1FT65 20212012 PTHR25462:SF291 BONUS, ISOFORM C-RELATED E3 UBIQUITIN-PROTEIN LIGASE TRIM45 transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG82119|UniProtKB=T1G4N1 T1G4N1 20216029 PTHR46167:SF1 N-LYSINE METHYLTRANSFERASE KMT5A N-LYSINE METHYLTRANSFERASE KMT5A N-methyltransferase activity#GO:0008170;histone modifying activity#GO:0140993;transferase activity#GO:0016740;catalytic activity#GO:0003824;histone methyltransferase activity#GO:0042054;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;protein-lysine N-methyltransferase activity#GO:0016279;catalytic activity, acting on a protein#GO:0140096;lysine N-methyltransferase activity#GO:0016278;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein methyltransferase activity#GO:0008276 regulation of cell communication#GO:0010646;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of signaling#GO:0023051;regulation of response to stress#GO:0080134;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of intracellular signal transduction#GO:1902531;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular response to stress#GO:0080135;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG65967|UniProtKB=T1FYF4 T1FYF4 20213852 PTHR42790:SF19 AMINOTRANSFERASE KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL transaminase activity#GO:0008483;transferase activity#GO:0016740;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;nitrogen compound metabolic process#GO:0006807;alpha-amino acid metabolic process#GO:1901605;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 transaminase#PC00216 HELRO|EnsemblGenome=HelroG104724|UniProtKB=T1EDN4 T1EDN4 20194686 PTHR11540:SF16 MALATE AND LACTATE DEHYDROGENASE MALATE DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 Pyruvate metabolism#P02772>Lactate Dehydrogenase#P03139 HELRO|EnsemblGenome=HelroG104310|UniProtKB=T1EDK9 T1EDK9 20194661 PTHR22870:SF155 REGULATOR OF CHROMOSOME CONDENSATION E3 UBIQUITIN-PROTEIN LIGASE HERC1-RELATED guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG185172|UniProtKB=T1FMG8 T1FMG8 20210017 PTHR11588:SF462 TUBULIN TUBULIN ALPHA CHAIN carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;structural molecule activity#GO:0005198;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;structural constituent of cytoskeleton#GO:0005200 cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;microtubule-based process#GO:0007017;organelle organization#GO:0006996;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;cell cycle#GO:0007049;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 tubulin#PC00228;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG185174|UniProtKB=T1FMG9 T1FMG9 20210018 PTHR14205:SF15 WD-REPEAT PROTEIN EARP AND GARP COMPLEX-INTERACTING PROTEIN 1 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG174251|UniProtKB=T1F7W0 T1F7W0 20204909 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG77586|UniProtKB=T1G302 T1G302 20215450 PTHR11265:SF0 S-ADENOSYL-METHYLTRANSFERASE MRAW 12S RRNA N4-METHYLCYTIDINE METHYLTRANSFERASE catalytic activity, acting on RNA#GO:0140098;N-methyltransferase activity#GO:0008170;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on a rRNA#GO:0140102;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;rRNA methyltransferase activity#GO:0008649;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;RNA methyltransferase activity#GO:0008173 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA modification#GO:0009451;rRNA modification#GO:0000154;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;ribosome biogenesis#GO:0042254;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;rRNA methylation#GO:0031167;nucleic acid metabolic process#GO:0090304;methylation#GO:0032259;macromolecule methylation#GO:0043414;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;rRNA base methylation#GO:0070475;RNA methylation#GO:0001510 methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG178735|UniProtKB=T1FDN1 T1FDN1 20206930 PTHR19890:SF10 FIBROBLAST GROWTH FACTOR RECEPTOR FIBROBLAST GROWTH FACTOR RECEPTOR-LIKE 1 transmembrane signal receptor#PC00197;tyrosine protein kinase receptor#PC00233 HELRO|EnsemblGenome=HelroG184902|UniProtKB=T1FM54 T1FM54 20209903 PTHR11353:SF94 CHAPERONIN T-COMPLEX PROTEIN 1 SUBUNIT EPSILON protein binding#GO:0005515;unfolded protein binding#GO:0051082;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 chaperonin#PC00073 HELRO|EnsemblGenome=HelroG88926|UniProtKB=T1G774 T1G774 20216921 PTHR14273:SF0 LYR MOTIF-CONTAINING PROTEIN 1 LYR MOTIF-CONTAINING PROTEIN 1 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG97320|UniProtKB=T1G9G4 T1G9G4 20217711 PTHR45911:SF4 C2 DOMAIN-CONTAINING PROTEIN MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG178532|UniProtKB=T1FDB7 T1FDB7 20206816 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184292|UniProtKB=T1FKX4 T1FKX4 20209473 PTHR45698:SF1 TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG193389|UniProtKB=T1FUX9 T1FUX9 20212625 PTHR24241:SF76 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR NEUROPEPTIDE SIFAMIDE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;binding#GO:0005488;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888;amide binding#GO:0033218 response to organic substance#GO:0010033;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;response to hormone#GO:0009725;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG77249|UniProtKB=T1G2V0 T1G2V0 20215398 PTHR21178:SF8 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61 structural protein#PC00211 HELRO|EnsemblGenome=HelroG183592|UniProtKB=T1FJW4 T1FJW4 20209113 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185073|UniProtKB=T1FMD1 T1FMD1 20209980 PTHR10672:SF3 ADDUCIN PROTEIN HU-LI TAI SHAO cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG173089|UniProtKB=T1F6B7 T1F6B7 20204366 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG116733|UniProtKB=T1EGH4 T1EGH4 20195676 PTHR44395:SF1 FAMILY NOT NAMED PROTEIN O-MANNOSYL-TRANSFERASE TMTC3 HELRO|EnsemblGenome=HelroG184120|UniProtKB=T1FKM3 T1FKM3 20209372 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159218|UniProtKB=T1ENR3 T1ENR3 20198213 PTHR12496:SF0 CGI-41 METHYLTRANSFERASE METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN RNA metabolism protein#PC00031;RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG155340|UniProtKB=T1ELI0 T1ELI0 20197430 PTHR11941:SF45 ENOYL-COA HYDRATASE-RELATED ENOYL-COA DELTA ISOMERASE 1, MITOCHONDRIAL oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;lipid oxidation#GO:0034440;cellular metabolic process#GO:0044237;lipid catabolic process#GO:0016042;lipid modification#GO:0030258;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;fatty acid catabolic process#GO:0009062;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;fatty acid metabolic process#GO:0006631;small molecule catabolic process#GO:0044282;fatty acid beta-oxidation#GO:0006635;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;carboxylic acid metabolic process#GO:0019752;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 hydratase#PC00120 HELRO|EnsemblGenome=HelroG161908|UniProtKB=T1ES12 T1ES12 20199362 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG193233|UniProtKB=T1FUR9 T1FUR9 20212565 PTHR42264:SF3 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN F-BOX DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG183999|UniProtKB=T1FKE6 T1FKE6 20209295 PTHR34009:SF2 PROTEIN STAR PROTEIN STAR localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;endosomal transport#GO:0016197;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987 bounding membrane of organelle#GO:0098588;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;late endosome membrane#GO:0031902;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;endosome membrane#GO:0010008;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle membrane#GO:0030659;endoplasmic reticulum#GO:0005783;late endosome#GO:0005770;plasma membrane#GO:0005886;endoplasmic reticulum membrane#GO:0005789 HELRO|EnsemblGenome=HelroG174936|UniProtKB=T1F8M8 T1F8M8 20205177 PTHR13108:SF9 CONDENSIN COMPLEX SUBUNIT 2 CONDENSIN COMPLEX SUBUNIT 2 protein-containing complex binding#GO:0044877;binding#GO:0005488;chromatin binding#GO:0003682 nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;nuclear division#GO:0000280;cell cycle process#GO:0022402;chromosome condensation#GO:0030261;cellular component organization#GO:0016043;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047;chromosome segregation#GO:0007059;mitotic chromosome condensation#GO:0007076;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;chromosome organization#GO:0051276;organelle organization#GO:0006996;cell cycle#GO:0007049;mitotic nuclear division#GO:0140014;organelle fission#GO:0048285;mitotic sister chromatid segregation#GO:0000070 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG194585|UniProtKB=T1FW81 T1FW81 20213077 PTHR14058:SF8 AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B PROTEIN FE65 HOMOLOG amyloid-beta binding#GO:0001540;protein binding#GO:0005515;transcription factor binding#GO:0008134;binding#GO:0005488;peptide binding#GO:0042277;amide binding#GO:0033218 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG163252|UniProtKB=T1ETU4 T1ETU4 20199994 PTHR45698:SF1 TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG170742|UniProtKB=T1F3D6 T1F3D6 20203335 PTHR10749:SF7 PHOSPHORYLASE B KINASE REGULATORY SUBUNIT PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA-RELATED cytoplasm#GO:0005737;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622 kinase modulator#PC00140;kinase activator#PC00138 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716 HELRO|EnsemblGenome=HelroG155722|UniProtKB=T1ELL5 T1ELL5 20197465 PTHR10556:SF28 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE VERY-LONG-CHAIN ENOYL-COA REDUCTASE catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 organic acid biosynthetic process#GO:0016053;lipid metabolic process#GO:0006629;oxoacid metabolic process#GO:0043436;monocarboxylic acid biosynthetic process#GO:0072330;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;fatty acid metabolic process#GO:0006631;small molecule biosynthetic process#GO:0044283;cellular lipid metabolic process#GO:0044255;carboxylic acid metabolic process#GO:0019752;small molecule metabolic process#GO:0044281;fatty acid biosynthetic process#GO:0006633;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG170439|UniProtKB=T1F326 T1F326 20203225 PTHR16238:SF7 GEM-ASSOCIATED PROTEIN 8 GEM-ASSOCIATED PROTEIN 8 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;spliceosomal snRNP assembly#GO:0000387;organic substance metabolic process#GO:0071704;mRNA splicing, via spliceosome#GO:0000398;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375 SMN-Sm protein complex#GO:0034719;cytoplasm#GO:0005737;SMN complex#GO:0032797;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;Sm-like protein family complex#GO:0120114;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG166730|UniProtKB=T1EYF9 T1EYF9 20201609 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG99580|UniProtKB=T1G9T8 T1G9T8 20217834 PTHR21706:SF15 TRANSMEMBRANE PROTEIN 65 TRANSMEMBRANE PROTEIN 65 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG91651|UniProtKB=T1G872 T1G872 20217269 PTHR19321:SF41 PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED FASCETTO-RELATED cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule-based process#GO:0007017;organelle organization#GO:0006996 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;spindle#GO:0005819;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG74793|UniProtKB=T1G1V8 T1G1V8 20215056 PTHR15722:SF2 IFT140/172-RELATED INTRAFLAGELLAR TRANSPORT PROTEIN 172 HOMOLOG cilium organization#GO:0044782;cellular localization#GO:0051641;cell projection organization#GO:0030030;transport#GO:0006810;microtubule-based movement#GO:0007018;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;transport along microtubule#GO:0010970;intraciliary transport#GO:0042073;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;microtubule-based transport#GO:0099111;establishment of localization#GO:0051234;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;protein-containing complex localization#GO:0031503 axoneme#GO:0005930;microtubule organizing center#GO:0005815;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;intraciliary transport particle B#GO:0030992;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;ciliary plasm#GO:0097014;plasma membrane bounded cell projection cytoplasm#GO:0032838;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cytoskeleton#GO:0005856;cilium#GO:0005929;intraciliary transport particle#GO:0030990 structural protein#PC00211 HELRO|EnsemblGenome=HelroG193706|UniProtKB=T1FVA2 T1FVA2 20212748 PTHR43016:SF13 PRESEQUENCE PROTEASE PRESEQUENCE PROTEASE, MITOCHONDRIAL metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG166455|UniProtKB=T1EY55 T1EY55 20201505 PTHR11842:SF10 MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2 MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B DNA polymerase complex#GO:0042575;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234 HELRO|EnsemblGenome=HelroG156526|UniProtKB=T1ELY0 T1ELY0 20197580 PTHR10792:SF8 60S RIBOSOMAL PROTEIN L24 RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;ribosome biogenesis#GO:0042254;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;ribonucleoprotein complex biogenesis#GO:0022613 membrane-enclosed lumen#GO:0031974;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG124458|UniProtKB=T1EH15 T1EH15 20195865 PTHR24044:SF502 NOTCH LIGAND FAMILY MEMBER ANTERIOR PHARYNX IN EXCESS PROTEIN 1-RELATED protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG170239|UniProtKB=T1F2T5 T1F2T5 20203134 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192366|UniProtKB=T1FTV2 T1FTV2 20212249 PTHR10749:SF8 PHOSPHORYLASE B KINASE REGULATORY SUBUNIT PHOSPHORYLASE B KINASE REGULATORY SUBUNIT BETA cytoplasm#GO:0005737;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622 kinase modulator#PC00140;kinase activator#PC00138 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716 HELRO|EnsemblGenome=HelroG168124|UniProtKB=T1F071 T1F071 20202221 PTHR13098:SF3 WOLFRAMIN WOLFRAMIN response to organic substance#GO:0010033;inorganic ion homeostasis#GO:0098771;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;endoplasmic reticulum unfolded protein response#GO:0030968;calcium ion homeostasis#GO:0055074;response to endoplasmic reticulum stress#GO:0034976;cellular response to chemical stimulus#GO:0070887;cellular response to organic substance#GO:0071310;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;cell communication#GO:0007154;chemical homeostasis#GO:0048878;cellular process#GO:0009987;cellular response to topologically incorrect protein#GO:0035967;monoatomic ion homeostasis#GO:0050801;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;cellular response to unfolded protein#GO:0034620;response to unfolded protein#GO:0006986;response to topologically incorrect protein#GO:0035966;biological regulation#GO:0065007;cellular response to stress#GO:0033554;signaling#GO:0023052 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG179569|UniProtKB=T1FEW0 T1FEW0 20207359 PTHR43104:SF2 L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 dehydrogenase#PC00092;oxidoreductase#PC00176 Ornithine degradation#P02758>Aminobutyraldehyde dehydrogenase#P03055 HELRO|EnsemblGenome=HelroG71319|UniProtKB=T1G0J5 T1G0J5 20214593 PTHR24347:SF393 SERINE/THREONINE-PROTEIN KINASE SPAGHETTI-SQUASH ACTIVATOR, ISOFORM C transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>MLCK#P00877;Cytoskeletal regulation by Rho GTPase#P00016>MLCK#P00514 HELRO|EnsemblGenome=HelroG179757|UniProtKB=T1FF45 T1FF45 20207444 PTHR23198:SF6 NUCLEOPORIN NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96 transporter#PC00227 HELRO|EnsemblGenome=HelroG185476|UniProtKB=T1FMV3 T1FMV3 20210152 PTHR42738:SF7 HYDROXYMETHYLGLUTARYL-COA LYASE HYDROXYMETHYLGLUTARYL-COA LYASE lyase activity#GO:0016829;carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;branched-chain amino acid metabolic process#GO:0009081;generation of precursor metabolites and energy#GO:0006091;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;organic acid metabolic process#GO:0006082;primary metabolic process#GO:0044238;amino acid catabolic process#GO:0009063;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;nitrogen compound metabolic process#GO:0006807;alpha-amino acid metabolic process#GO:1901605;catabolic process#GO:0009056;small molecule biosynthetic process#GO:0044283;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 lyase#PC00144 HELRO|EnsemblGenome=HelroG175359|UniProtKB=T1F970 T1F970 20205369 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164081|UniProtKB=T1EUW3 T1EUW3 20200363 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG63981|UniProtKB=T1FXN2 T1FXN2 20213580 PTHR11909:SF155 CASEIN KINASE-RELATED GILGAMESH, ISOFORM L transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 signal transduction#GO:0007165;macromolecule modification#GO:0043412;transport#GO:0006810;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;endocytosis#GO:0006897;cellular metabolic process#GO:0044237;vesicle-mediated transport#GO:0016192;organonitrogen compound metabolic process#GO:1901564;protein phosphorylation#GO:0006468;cell communication#GO:0007154;cellular process#GO:0009987;primary metabolic process#GO:0044238;localization#GO:0051179;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;import into cell#GO:0098657 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Parkinson disease#P00049>Casein kinase I#P01242 HELRO|EnsemblGenome=HelroG189687|UniProtKB=T1FR93 T1FR93 20211340 PTHR24388:SF53 ZINC FINGER PROTEIN CHORION TRANSCRIPTION FACTOR CF2-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG171907|UniProtKB=T1F4T8 T1F4T8 20203837 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG175922|UniProtKB=T1F9W3 T1F9W3 20205612 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG156892|UniProtKB=T1EM27 T1EM27 20197627 PTHR23089:SF33 HISTIDINE TRIAD HIT PROTEIN ADENOSINE 5'-MONOPHOSPHORAMIDASE HINT1 hydrolase activity#GO:0016787;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 nucleotide phosphatase#PC00173 HELRO|EnsemblGenome=HelroG192229|UniProtKB=T1FTQ8 T1FTQ8 20212205 PTHR24030:SF0 PROTEIN CMSS1 PROTEIN CMSS1 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;90S preribosome#GO:0030686;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG73845|UniProtKB=T1G1J2 T1G1J2 20214940 PTHR21220:SF0 DNA-DEPENDENT METALLOPROTEASE SPRTN DNA-DEPENDENT METALLOPROTEASE SPRTN protein binding#GO:0005515;binding#GO:0005488;polyubiquitin modification-dependent protein binding#GO:0031593;modification-dependent protein binding#GO:0140030 response to stimulus#GO:0050896;DNA damage response#GO:0006974;cellular response to stimulus#GO:0051716;response to stress#GO:0006950;cellular process#GO:0009987;cellular response to stress#GO:0033554 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG173161|UniProtKB=T1F6H3 T1F6H3 20204422 PTHR47027:SF20 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN HELRO|EnsemblGenome=HelroG165229|UniProtKB=T1EWG8 T1EWG8 20200918 PTHR10877:SF183 POLYCYSTIN FAMILY MEMBER AT14535P-RELATED ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG185038|UniProtKB=T1FMB4 T1FMB4 20209963 PTHR13395:SF6 SISTER CHROMATID COHESION PROTEIN DCC1-RELATED SISTER CHROMATID COHESION PROTEIN DCC1 cellular component organization or biogenesis#GO:0071840;sister chromatid cohesion#GO:0007062;mitotic sister chromatid cohesion#GO:0007064;organelle organization#GO:0006996;chromosome organization#GO:0051276;cell cycle process#GO:0022402;cell cycle#GO:0007049;cellular component organization#GO:0016043;cellular process#GO:0009987 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;chromatin#GO:0000785;chromosome, centromeric region#GO:0000775;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;chromosomal region#GO:0098687;nuclear protein-containing complex#GO:0140513 DNA metabolism protein#PC00009;replication origin binding protein#PC00199 HELRO|EnsemblGenome=HelroG170340|UniProtKB=T1F2X9 T1F2X9 20203178 PTHR21420:SF9 GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1 GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG181830|UniProtKB=T1FHE0 T1FHE0 20208239 PTHR16528:SF2 GOLGI-ASSOCIATED PDZ AND COILED-COIL MOTIF-CONTAINING GOLGI-ASSOCIATED PDZ AND COILED-COIL MOTIF-CONTAINING PROTEIN protein binding#GO:0005515;transmembrane transporter binding#GO:0044325;binding#GO:0005488 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of localization#GO:0032879;regulation of cellular localization#GO:0060341;negative regulation of cellular process#GO:0048523;regulation of protein localization#GO:0032880 intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;coated vesicle#GO:0030135;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;clathrin-coated vesicle#GO:0030136;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;Golgi-associated vesicle#GO:0005798;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;trans-Golgi network transport vesicle#GO:0030140 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG108840|UniProtKB=T1EEM9 T1EEM9 20195031 PTHR46070:SF1 PINSTRIPE, ISOFORM A PINSTRIPE, ISOFORM A nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;binding#GO:0005488;enzyme binding#GO:0019899;protein binding#GO:0005515;small GTPase binding#GO:0031267;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 HELRO|EnsemblGenome=HelroG159178|UniProtKB=T1ENP9 T1ENP9 20198199 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG167700|UniProtKB=T1EZP6 T1EZP6 20202046 PTHR46232:SF1 SMARCE1 REGULATOR OF CHROMATIN SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1 nucleosome binding#GO:0031491;nucleic acid binding#GO:0003676;chromatin DNA binding#GO:0031490;nuclear receptor binding#GO:0016922;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;DNA binding#GO:0003677;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;transcription factor binding#GO:0008134;DNA-binding transcription factor binding#GO:0140297 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;ATPase complex#GO:1904949;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;SWI/SNF complex#GO:0016514;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG183694|UniProtKB=T1FK21 T1FK21 20209170 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG105135|UniProtKB=T1EDR2 T1EDR2 20194714 PTHR20952:SF0 ADP-RIBOSYLATION-LIKE FACTOR 6-INTERACTING PROTEIN ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 6-INTERACTING PROTEIN 1 HELRO|EnsemblGenome=HelroG154764|UniProtKB=T1ELG0 T1ELG0 20197410 PTHR13691:SF16 RIBOSOMAL PROTEIN L2 LARGE RIBOSOMAL SUBUNIT PROTEIN UL2 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cytoplasmic translation#GO:0002181;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG159369|UniProtKB=T1ENY4 T1ENY4 20198284 PTHR24243:SF233 G-PROTEIN COUPLED RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG169261|UniProtKB=T1F1N3 T1F1N3 20202733 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189781|UniProtKB=T1FRD4 T1FRD4 20211381 PTHR15495:SF7 NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED GPI INOSITOL-DEACYLASE hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;lipid metabolic process#GO:0006629;cellular localization#GO:0051641;carbohydrate derivative metabolic process#GO:1901135;transport#GO:0006810;glycolipid metabolic process#GO:0006664;vesicle-mediated transport#GO:0016192;cellular metabolic process#GO:0044237;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;liposaccharide metabolic process#GO:1903509;Golgi vesicle transport#GO:0048193;GPI anchor metabolic process#GO:0006505;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;localization#GO:0051179;glycerolipid metabolic process#GO:0046486;membrane lipid metabolic process#GO:0006643;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;organophosphate metabolic process#GO:0019637;intracellular transport#GO:0046907;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG107370|UniProtKB=T1EEA1 T1EEA1 20194903 PTHR12726:SF0 CERAMIDE GLUCOSYLTRANSFERASE CERAMIDE GLUCOSYLTRANSFERASE UDP-glucosyltransferase activity#GO:0035251;glucosyltransferase activity#GO:0046527;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;glycosphingolipid biosynthetic process#GO:0006688;glycolipid metabolic process#GO:0006664;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;liposaccharide metabolic process#GO:1903509;membrane lipid biosynthetic process#GO:0046467;sphingolipid metabolic process#GO:0006665;primary metabolic process#GO:0044238;ceramide metabolic process#GO:0006672;amide biosynthetic process#GO:0043604;carbohydrate derivative biosynthetic process#GO:1901137;membrane lipid metabolic process#GO:0006643;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;ceramide biosynthetic process#GO:0046513;glycolipid biosynthetic process#GO:0009247;cellular lipid metabolic process#GO:0044255;amide metabolic process#GO:0043603;sphingolipid biosynthetic process#GO:0030148;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;membrane#GO:0016020 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG177979|UniProtKB=T1FCK2 T1FCK2 20206551 PTHR19411:SF0 PROTEIN BUD31-RELATED PROTEIN BUD31 HOMOLOG cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG90408|UniProtKB=T1G7R0 T1G7R0 20217107 PTHR31606:SF1 WW DOMAIN BINDING PROTEIN 2, ISOFORM E WW DOMAIN BINDING PROTEIN 2, ISOFORM E molecular adaptor activity#GO:0060090;nucleic acid binding#GO:0003676;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;chromatin DNA binding#GO:0031490;binding#GO:0005488;organic cyclic compound binding#GO:0097159;chromatin binding#GO:0003682;protein-macromolecule adaptor activity#GO:0030674;DNA binding#GO:0003677;transcription coactivator activity#GO:0003713;protein-containing complex binding#GO:0044877 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG165876|UniProtKB=T1EXE1 T1EXE1 20201241 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG69911|UniProtKB=T1FZZ5 T1FZZ5 20214393 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158131|UniProtKB=T1EMJ7 T1EMJ7 20197797 PTHR10352:SF25 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G FOUND IN NEURONS, ISOFORM A-RELATED translation initiation factor#PC00224;translation factor#PC00223 HELRO|EnsemblGenome=HelroG185026|UniProtKB=T1FMA8 T1FMA8 20209957 PTHR19923:SF0 WD40 REPEAT PROTEINPRL1/PRL2-RELATED PLEIOTROPIC REGULATOR 1 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;catalytic step 2 spliceosome#GO:0071013;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;precatalytic spliceosome#GO:0071011;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;Prp19 complex#GO:0000974;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185061|UniProtKB=T1FMC3 T1FMC3 20209972 PTHR12710:SF0 NUCLEAR PROTEIN LOCALIZATION 4 NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG enzyme binding#GO:0019899;protein binding#GO:0005515;ubiquitin-like protein binding#GO:0032182;ubiquitin protein ligase binding#GO:0031625;binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389;ubiquitin binding#GO:0043130 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG165282|UniProtKB=T1EWJ1 T1EWJ1 20200941 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182086|UniProtKB=T1FHQ0 T1FHQ0 20208349 PTHR31196:SF2 RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED HELRO|EnsemblGenome=HelroG187369|UniProtKB=T1FP94 T1FP94 20210641 PTHR28570:SF3 ASPARTYL AMINOPEPTIDASE ASPARTYL AMINOPEPTIDASE metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG159552|UniProtKB=T1EP55 T1EP55 20198355 PTHR22655:SF2 ATP-DEPENDENT RNA HELICASE TDRD12-RELATED ATP-DEPENDENT RNA HELICASE TDRD12-RELATED germ cell development#GO:0007281;cellular developmental process#GO:0048869;cell division#GO:0051301;gamete generation#GO:0007276;cellular process involved in reproduction in multicellular organism#GO:0022412;multicellular organism reproduction#GO:0032504;developmental process#GO:0032502;cellular process#GO:0009987;developmental process involved in reproduction#GO:0003006;cell development#GO:0048468;cell differentiation#GO:0030154;reproduction#GO:0000003;anatomical structure development#GO:0048856;sexual reproduction#GO:0019953;reproductive process#GO:0022414;multicellular organismal process#GO:0032501;multicellular organismal reproductive process#GO:0048609 HELRO|EnsemblGenome=HelroG90898|UniProtKB=T1G7X7 T1G7X7 20217174 PTHR14413:SF16 RIBOSOMAL PROTEIN L17 LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;large ribosomal subunit#GO:0015934;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG193660|UniProtKB=T1FV87 T1FV87 20212733 PTHR32385:SF15 MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1 mannosyltransferase activity#GO:0000030;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;glycosphingolipid biosynthetic process#GO:0006688;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;glycolipid metabolic process#GO:0006664;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;liposaccharide metabolic process#GO:1903509;membrane lipid biosynthetic process#GO:0046467;sphingolipid metabolic process#GO:0006665;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;carbohydrate derivative biosynthetic process#GO:1901137;membrane lipid metabolic process#GO:0006643;nitrogen compound metabolic process#GO:0006807;glycolipid biosynthetic process#GO:0009247;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;sphingolipid biosynthetic process#GO:0030148;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG84403|UniProtKB=T1G5I4 T1G5I4 20216331 PTHR11999:SF70 GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE MIP05841P decarboxylase#PC00089 5-Hydroxytryptamine biosynthesis#P04371>Aromatic L-amino acid decarboxylase#P04400;Dopamine receptor mediated signaling pathway#P05912>DOPA decarb.#P05961;Adrenaline and noradrenaline biosynthesis#P00001>DOPA decarb.#P00066 HELRO|EnsemblGenome=HelroG178771|UniProtKB=T1FDQ0 T1FDQ0 20206949 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG190175|UniProtKB=T1FRR6 T1FRR6 20211513 PTHR23202:SF124 WASP INTERACTING PROTEIN-RELATED C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG88168|UniProtKB=T1G6Z3 T1G6Z3 20216840 PTHR12411:SF929 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN Z cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197 macromolecule catabolic process#GO:0009057;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;proteolysis#GO:0006508;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;catabolic process#GO:0009056;organonitrogen compound catabolic process#GO:1901565;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;lysosome#GO:0005764;intracellular membrane-bounded organelle#GO:0043231;extracellular region#GO:0005576;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;organelle#GO:0043226;lytic vacuole#GO:0000323;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG165139|UniProtKB=T1EWC1 T1EWC1 20200871 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG115644|UniProtKB=T1EG97 T1EG97 20195599 PTHR11188:SF144 ARRESTIN DOMAIN CONTAINING PROTEIN ARRESTIN C-TERMINAL-LIKE DOMAIN-CONTAINING PROTEIN localization#GO:0051179;organic substance transport#GO:0071702;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;protein transport#GO:0015031;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG72949|UniProtKB=T1G177 T1G177 20214825 PTHR12377:SF0 CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;gene expression#GO:0010467;protein maturation#GO:0051604;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;primary metabolic process#GO:0044238 HELRO|EnsemblGenome=HelroG171241|UniProtKB=T1F3Z5 T1F3Z5 20203544 PTHR14058:SF8 AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B PROTEIN FE65 HOMOLOG amyloid-beta binding#GO:0001540;protein binding#GO:0005515;transcription factor binding#GO:0008134;binding#GO:0005488;peptide binding#GO:0042277;amide binding#GO:0033218 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG77167|UniProtKB=T1G2T7 T1G2T7 20215385 PTHR22811:SF45 TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 6 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;Golgi organization#GO:0007030;macromolecule localization#GO:0033036;transport#GO:0006810;endomembrane system organization#GO:0010256;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;organelle organization#GO:0006996;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;endoplasmic reticulum#GO:0005783;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG83374|UniProtKB=T1G549 T1G549 20216197 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG194672|UniProtKB=T1FWA8 T1FWA8 20213104 PTHR11731:SF193 PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED DIPEPTIDYL PEPTIDASE 9 hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;metabolic process#GO:0008152;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG174754|UniProtKB=T1F8F8 T1F8F8 20205107 PTHR12864:SF3 RAN BINDING PROTEIN 9-RELATED GLUCOSE-INDUCED DEGRADATION PROTEIN 8 HOMOLOG macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG84435|UniProtKB=T1G5I6 T1G5I6 20216333 PTHR14388:SF17 T CELL-SPECIFIC ADAPTER PROTEIN TSAD SH2 DOMAIN-CONTAINING PROTEIN cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG115173|UniProtKB=T1EG69 T1EG69 20195571 PTHR10856:SF0 CORONIN CORONIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG170768|UniProtKB=T1F3E4 T1F3E4 20203343 PTHR15117:SF24 ATAXIN 7 RELATED SCA7 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG96072|UniProtKB=T1G9A1 T1G9A1 20217648 PTHR12131:SF7 ATP-DEPENDENT RNA AND DNA HELICASE EXOSOME RNA HELICASE MTR4 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of 5.8S rRNA#GO:0000460;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG194469|UniProtKB=T1FW33 T1FW33 20213029 PTHR11814:SF257 SULFATE TRANSPORTER ANION TRANSPORTER SULP-7D inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;organic acid transmembrane transporter activity#GO:0005342;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;organic anion transmembrane transporter activity#GO:0008514;inorganic anion transmembrane transporter activity#GO:0015103;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG179923|UniProtKB=T1FF92 T1FF92 20207491 PTHR21568:SF0 TRNA PSEUDOURIDINE SYNTHASE PUS10 TRNA PSEUDOURIDINE SYNTHASE PUS10 isomerase activity#GO:0016853;intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;tRNA metabolic process#GO:0006399;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;pseudouridine synthesis#GO:0001522;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 HELRO|EnsemblGenome=HelroG155381|UniProtKB=T1ELI1 T1ELI1 20197431 PTHR32026:SF10 METHYLTRANSFERASE-LIKE PROTEIN 24 METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG145945|UniProtKB=T1EJP1 T1EJP1 20196791 PTHR33332:SF40 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159794|UniProtKB=T1EPE9 T1EPE9 20198449 PTHR42264:SF3 EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN F-BOX DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG90622|UniProtKB=T1G7T5 T1G7T5 20217132 PTHR11360:SF260 MONOCARBOXYLATE TRANSPORTER MFS DOMAIN-CONTAINING PROTEIN transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;monocarboxylic acid transmembrane transporter activity#GO:0008028;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;monocarboxylic acid transport#GO:0015718;establishment of localization#GO:0051234;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942 transporter#PC00227 HELRO|EnsemblGenome=HelroG168627|UniProtKB=T1F0T3 T1F0T3 20202433 PTHR24020:SF84 COLLAGEN ALPHA VWFA DOMAIN-CONTAINING PROTEIN extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG172157|UniProtKB=T1F530 T1F530 20203929 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG160319|UniProtKB=T1EQ33 T1EQ33 20198683 PTHR19972:SF10 CALBINDIN CALBINDIN-32 cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;intracellular monoatomic cation homeostasis#GO:0030003;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic ion homeostasis#GO:0006873;cellular homeostasis#GO:0019725;regulation of cytosolic calcium ion concentration#GO:0051480;intracellular chemical homeostasis#GO:0055082;chemical homeostasis#GO:0048878;intracellular calcium ion homeostasis#GO:0006874;monoatomic ion homeostasis#GO:0050801 cytoplasm#GO:0005737;synapse#GO:0045202;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;neuron projection#GO:0043005;cell junction#GO:0030054;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG194864|UniProtKB=T1FWI0 T1FWI0 20213175 PTHR44196:SF1 DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B cellular anatomical entity#GO:0110165;membrane#GO:0016020 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG180520|UniProtKB=T1FG02 T1FG02 20207751 PTHR15712:SF23 ARMADILLO REPEAT CONTAINING PROTEIN ARMADILLO REPEAT CONTAINING 10 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG127865|UniProtKB=T1EHJ0 T1EHJ0 20196040 PTHR11849:SF304 ETS DNA-BINDING PROTEIN D-ETS-3 transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG105218|UniProtKB=T1EDR8 T1EDR8 20194720 PTHR11566:SF21 DYNAMIN DYNAMIN RELATED PROTEIN 1, ISOFORM A GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;microtubule binding#GO:0008017;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;ribonucleoside triphosphate phosphatase activity#GO:0017111 supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;organelle#GO:0043226;membrane#GO:0016020;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG76345|UniProtKB=T1G2I5 T1G2I5 20215283 PTHR23073:SF12 26S PROTEASOME REGULATORY SUBUNIT 26S PROTEASOME REGULATORY SUBUNIT 8 ATP-dependent activity#GO:0140657 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 peptidase complex#GO:1905368;protein-containing complex#GO:0032991;proteasome accessory complex#GO:0022624;proteasome regulatory particle#GO:0005838;catalytic complex#GO:1902494;proteasome complex#GO:0000502;endopeptidase complex#GO:1905369;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 protease#PC00190;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HELRO|EnsemblGenome=HelroG121430|UniProtKB=T1EGS0 T1EGS0 20195770 PTHR11229:SF8 50S RIBOSOMAL PROTEIN L3 LARGE RIBOSOMAL SUBUNIT PROTEIN UL3M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrial large ribosomal subunit#GO:0005762;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;organellar ribosome#GO:0000313;protein-containing complex#GO:0032991;large ribosomal subunit#GO:0015934;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840;mitochondrial protein-containing complex#GO:0098798 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG74572|UniProtKB=T1G1T0 T1G1T0 20215028 PTHR45695:SF26 LEUCOKININ RECEPTOR-RELATED NEUROPEPTIDE CCHAMIDE-1 RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG72073|UniProtKB=T1G0V1 T1G0V1 20214699 PTHR12681:SF0 ZINC FINGER-CONTAINING PROTEIN P48ZNF ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cytoplasmic translation#GO:0002181;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG77115|UniProtKB=T1G2T3 T1G2T3 20215381 PTHR11127:SF2 60S RIBOSOMAL PROTEIN L14 LARGE RIBOSOMAL SUBUNIT PROTEIN EL14 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;ribosome biogenesis#GO:0042254;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;ribonucleoprotein complex biogenesis#GO:0022613 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG179523|UniProtKB=T1FEU4 T1FEU4 20207343 PTHR31547:SF1 MULTIVESICULAR BODY SUBUNIT 12B MULTIVESICULAR BODY SUBUNIT 12B regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;regulation of signaling#GO:0023051;biological regulation#GO:0065007;regulation of ERBB signaling pathway#GO:1901184 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;vesicle membrane#GO:0012506;organelle#GO:0043226;membrane#GO:0016020;endosome membrane#GO:0010008;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ESCRT I complex#GO:0000813;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770 HELRO|EnsemblGenome=HelroG90077|UniProtKB=T1G7K9 T1G7K9 20217056 PTHR44085:SF2 SEPIAPTERIN REDUCTASE SEPIAPTERIN REDUCTASE oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 cellular aromatic compound metabolic process#GO:0006725;organic hydroxy compound metabolic process#GO:1901615;heterocycle metabolic process#GO:0046483;alcohol biosynthetic process#GO:0046165;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic hydroxy compound biosynthetic process#GO:1901617;alcohol metabolic process#GO:0006066;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;small molecule biosynthetic process#GO:0044283;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 reductase#PC00198;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG191216|UniProtKB=T1FSR1 T1FSR1 20211858 PTHR24073:SF1125 DRAB5-RELATED RE48347P GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;macroautophagy#GO:0016236;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organelle assembly#GO:0070925;process utilizing autophagic mechanism#GO:0061919;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;vacuole organization#GO:0007033;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;organelle organization#GO:0006996;protein transport#GO:0015031;autophagosome assembly#GO:0000045;catabolic process#GO:0009056;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;autophagy#GO:0006914;metabolic process#GO:0008152;cellular catabolic process#GO:0044248 cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG63562|UniProtKB=T1FXH5 T1FXH5 20213523 PTHR19836:SF19 30S RIBOSOMAL PROTEIN S14 SMALL RIBOSOMAL SUBUNIT PROTEIN US14M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;small ribosomal subunit#GO:0015935;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG179278|UniProtKB=T1FEH0 T1FEH0 20207219 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG109966|UniProtKB=T1EEX8 T1EEX8 20195130 PTHR10682:SF10 POLY A POLYMERASE POLYNUCLEOTIDE ADENYLYLTRANSFERASE adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;RNA processing#GO:0006396;mRNA polyadenylation#GO:0006378;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;mRNA 3'-end processing#GO:0031124;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mRNA processing#GO:0006397;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG82844|UniProtKB=T1G4X2 T1G4X2 20216120 PTHR19229:SF250 ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;lipid transporter activity#GO:0005319;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;organic substance transport#GO:0071702;lipid localization#GO:0010876;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;lipid transport#GO:0006869;transport#GO:0006810 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG171105|UniProtKB=T1F3T4 T1F3T4 20203483 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG159697|UniProtKB=T1EPB6 T1EPB6 20198416 PTHR42650:SF1 TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1 protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 protein insertion into ER membrane#GO:0045048;localization within membrane#GO:0051668;cellular localization#GO:0051641;endoplasmic reticulum organization#GO:0007029;macromolecule localization#GO:0033036;membrane organization#GO:0061024;protein localization to membrane#GO:0072657;endomembrane system organization#GO:0010256;cellular component organization#GO:0016043;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to membrane#GO:0090150;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;organelle organization#GO:0006996;protein localization to organelle#GO:0033365;protein insertion into membrane#GO:0051205 cytoplasm#GO:0005737;endoplasmic reticulum protein-containing complex#GO:0140534;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG184900|UniProtKB=T1FM52 T1FM52 20209901 PTHR11902:SF1 ENOLASE ENOLASE lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;ribonucleoside triphosphate metabolic process#GO:0009199;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative metabolic process#GO:1901135;heterocycle catabolic process#GO:0046700;organonitrogen compound catabolic process#GO:1901565;ribonucleotide catabolic process#GO:0009261;pyridine nucleotide metabolic process#GO:0019362;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;cellular nitrogen compound catabolic process#GO:0044270;purine-containing compound catabolic process#GO:0072523;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;purine nucleotide catabolic process#GO:0006195;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;purine ribonucleotide catabolic process#GO:0009154;nucleoside phosphate metabolic process#GO:0006753;carbohydrate catabolic process#GO:0016052;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound metabolic process#GO:0072524;catabolic process#GO:0009056;nucleoside diphosphate metabolic process#GO:0009132;organic substance catabolic process#GO:1901575;carbohydrate metabolic process#GO:0005975;purine nucleotide metabolic process#GO:0006163;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;oxoacid metabolic process#GO:0043436;nucleoside phosphate catabolic process#GO:1901292;carbohydrate derivative catabolic process#GO:1901136;purine ribonucleoside triphosphate metabolic process#GO:0009205;generation of precursor metabolites and energy#GO:0006091;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;nucleotide catabolic process#GO:0009166;cellular nitrogen compound metabolic process#GO:0034641;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;nucleoside diphosphate catabolic process#GO:0009134;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;organophosphate catabolic process#GO:0046434;aromatic compound catabolic process#GO:0019439;glycolytic process#GO:0006096;organic cyclic compound catabolic process#GO:1901361;organophosphate metabolic process#GO:0019637;purine nucleoside triphosphate metabolic process#GO:0009144;nucleobase-containing compound catabolic process#GO:0034655;nucleotide metabolic process#GO:0009117;carboxylic acid metabolic process#GO:0019752;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 lyase#PC00144 Glycolysis#P00024>Enolase#P00678 HELRO|EnsemblGenome=HelroG172284|UniProtKB=T1F565 T1F565 20203964 PTHR23216:SF1 NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1 NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1 HELRO|EnsemblGenome=HelroG180527|UniProtKB=T1FG07 T1FG07 20207756 PTHR21444:SF14 COILED-COIL DOMAIN-CONTAINING PROTEIN 180 COILED-COIL DOMAIN-CONTAINING PROTEIN 180 HELRO|EnsemblGenome=HelroG192218|UniProtKB=T1FTQ2 T1FTQ2 20212199 PTHR23427:SF2 SURFEIT LOCUS PROTEIN SURFEIT LOCUS PROTEIN 1 chaperone#PC00072 HELRO|EnsemblGenome=HelroG111475|UniProtKB=T1EFB6 T1EFB6 20195268 PTHR23025:SF3 TRIACYLGLYCEROL LIPASE HORMONE-SENSITIVE LIPASE hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824;triglyceride lipase activity#GO:0004806 lipid metabolic process#GO:0006629;triglyceride metabolic process#GO:0006641;neutral lipid catabolic process#GO:0046461;cellular metabolic process#GO:0044237;glycerolipid catabolic process#GO:0046503;triglyceride catabolic process#GO:0019433;lipid catabolic process#GO:0016042;cellular process#GO:0009987;acylglycerol metabolic process#GO:0006639;primary metabolic process#GO:0044238;acylglycerol catabolic process#GO:0046464;neutral lipid metabolic process#GO:0006638;glycerolipid metabolic process#GO:0046486;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 lipase#PC00143 Triacylglycerol metabolism#P02782>Triacylglycerol lipase#P03205 HELRO|EnsemblGenome=HelroG173544|UniProtKB=T1F6Y7 T1F6Y7 20204586 PTHR11046:SF0 OLIGORIBONUCLEASE, MITOCHONDRIAL OLIGORIBONUCLEASE, MITOCHONDRIAL endoribonuclease#PC00094;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG169003|UniProtKB=T1F189 T1F189 20202589 PTHR37002:SF10 AGAP007005-PA TRANSGLUTAMINASE-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179508|UniProtKB=T1FET4 T1FET4 20207333 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162134|UniProtKB=T1ES99 T1ES99 20199449 PTHR11324:SF16 IL16-RELATED PDZ DOMAIN-CONTAINING PROTEIN 2 cytokine#PC00083;interleukin superfamily#PC00128 HELRO|EnsemblGenome=HelroG173799|UniProtKB=T1F787 T1F787 20204686 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG177499|UniProtKB=T1FBT1 T1FBT1 20206280 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG71557|UniProtKB=T1G0N3 T1G0N3 20214631 PTHR10953:SF5 UBIQUITIN-ACTIVATING ENZYME E1 SUMO-ACTIVATING ENZYME SUBUNIT 2 ligase activity#GO:0016874;transferase activity#GO:0016740;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877;nucleotidyltransferase activity#GO:0016779;thiosulfate sulfurtransferase activity#GO:0004792;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity, acting on a protein#GO:0140096;sulfurtransferase activity#GO:0016783 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;protein sumoylation#GO:0016925;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E1#P01492 HELRO|EnsemblGenome=HelroG184274|UniProtKB=T1FKW4 T1FKW4 20209463 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG168802|UniProtKB=T1F0Z8 T1F0Z8 20202498 PTHR13802:SF52 MUCIN 4-RELATED MUCIN-4 HELRO|EnsemblGenome=HelroG179637|UniProtKB=T1FEY9 T1FEY9 20207388 PTHR10912:SF7 ADP-RIBOSYL CYCLASE ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE lyase activity#GO:0016829;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824 regulation of multicellular organismal process#GO:0051239;regulation of cell population proliferation#GO:0042127;positive regulation of cell population proliferation#GO:0008284;positive regulation of immune system process#GO:0002684;positive regulation of lymphocyte activation#GO:0051251;positive regulation of leukocyte activation#GO:0002696;positive regulation of cellular process#GO:0048522;regulation of cell activation#GO:0050865;regulation of biological process#GO:0050789;regulation of leukocyte activation#GO:0002694;regulation of mononuclear cell proliferation#GO:0032944;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of lymphocyte proliferation#GO:0050670;regulation of immune system process#GO:0002682;regulation of leukocyte proliferation#GO:0070663;positive regulation of cell activation#GO:0050867;regulation of lymphocyte activation#GO:0051249;positive regulation of biological process#GO:0048518;regulation of B cell proliferation#GO:0030888;positive regulation of multicellular organismal process#GO:0051240 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 cyclase#PC00079;lyase#PC00144 HELRO|EnsemblGenome=HelroG180632|UniProtKB=T1FG38 T1FG38 20207787 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG63728|UniProtKB=T1FXJ3 T1FXJ3 20213541 PTHR23355:SF9 RIBONUCLEASE DIS3-LIKE EXONUCLEASE 2 negative regulation of gene expression#GO:0010629;cellular aromatic compound metabolic process#GO:0006725;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;heterocycle catabolic process#GO:0046700;RNA metabolic process#GO:0016070;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;mRNA catabolic process#GO:0006402;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;organic substance catabolic process#GO:1901575;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;heterocycle metabolic process#GO:0046483;macromolecule catabolic process#GO:0009057;negative regulation of biosynthetic process#GO:0009890;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;negative regulation of metabolic process#GO:0009892;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid metabolic process#GO:0090304;aromatic compound catabolic process#GO:0019439;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 RNA metabolism protein#PC00031;exoribonuclease#PC00099 HELRO|EnsemblGenome=HelroG189609|UniProtKB=T1FR72 T1FR72 20211319 PTHR19964:SF92 MULTIPLE PDZ DOMAIN PROTEIN PATJ HOMOLOG scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG161995|UniProtKB=T1ES48 T1ES48 20199398 PTHR43696:SF9 COILED-COIL DOMAIN-CONTAINING PROTEIN 157 COILED-COIL DOMAIN-CONTAINING PROTEIN 157 HELRO|EnsemblGenome=HelroG74848|UniProtKB=T1G1W4 T1G1W4 20215062 PTHR11695:SF294 ALCOHOL DEHYDROGENASE RELATED RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG100036|UniProtKB=T1ECY3 T1ECY3 20194435 PTHR13123:SF7 LD30288P LD30288P protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 SCF ubiquitin ligase complex#GO:0019005;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG182572|UniProtKB=T1FID6 T1FID6 20208585 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG81078|UniProtKB=T1G487 T1G487 20215885 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG156503|UniProtKB=T1ELX8 T1ELX8 20197578 PTHR24023:SF1097 COLLAGEN ALPHA COLLAGEN ALPHA-1(VII) CHAIN ISOFORM X1 structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG157973|UniProtKB=T1EMI4 T1EMI4 20197784 PTHR14068:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B nucleic acid binding#GO:0003676;translation regulator activity#GO:0045182;translation regulator activity, nucleic acid binding#GO:0090079;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation initiation factor activity#GO:0003743;translation factor activity, RNA binding#GO:0008135 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;translational initiation#GO:0006413;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;eukaryotic translation initiation factor 3 complex#GO:0005852;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG178014|UniProtKB=T1FCL9 T1FCL9 20206568 PTHR10334:SF498 CYSTEINE-RICH SECRETORY PROTEIN-RELATED MIP16674P defense/immunity protein#PC00090 PI3 kinase pathway#P00048>scl-1#G01545 HELRO|EnsemblGenome=HelroG103731|UniProtKB=T1EDH0 T1EDH0 20194622 PTHR43382:SF2 PROLYL-TRNA SYNTHETASE BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 Heme biosynthesis#P02746>Glutamyl-tRNA-synthetase#P02977 HELRO|EnsemblGenome=HelroG161763|UniProtKB=T1ERV6 T1ERV6 20199306 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG180976|UniProtKB=T1FGH3 T1FGH3 20207922 PTHR22802:SF463 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG169276|UniProtKB=T1F1P5 T1F1P5 20202745 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG152723|UniProtKB=T1EKW3 T1EKW3 20197213 PTHR12490:SF4 GSK3B-INTERACTING PROTEIN GSK3B-INTERACTING PROTEIN protein kinase A binding#GO:0051018;protein binding#GO:0005515;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;binding#GO:0005488;enzyme regulator activity#GO:0030234 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG164018|UniProtKB=T1EUS0 T1EUS0 20200320 PTHR33395:SF21 TRANSCRIPTASE, PUTATIVE-RELATED-RELATED PERICARDIN heart morphogenesis#GO:0003007;system development#GO:0048731;heart development#GO:0007507;circulatory system development#GO:0072359;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;animal organ development#GO:0048513;multicellular organism development#GO:0007275;developmental process#GO:0032502;animal organ morphogenesis#GO:0009887;multicellular organismal process#GO:0032501;cell adhesion#GO:0007155;cellular process#GO:0009987;post-embryonic development#GO:0009791 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944 HELRO|EnsemblGenome=HelroG116244|UniProtKB=T1EGD7 T1EGD7 20195639 PTHR45662:SF2 PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1 PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 phospholipid dephosphorylation#GO:0046839;lipid metabolic process#GO:0006629;phosphatidylinositol dephosphorylation#GO:0046856;cellular metabolic process#GO:0044237;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;lipid modification#GO:0030258;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;dephosphorylation#GO:0016311;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG65312|UniProtKB=T1FY58 T1FY58 20213756 PTHR10155:SF32 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT LP02169P enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 lipid metabolic process#GO:0006629;phospholipid biosynthetic process#GO:0008654;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol biosynthetic process#GO:0006661;glycerolipid biosynthetic process#GO:0045017;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;phosphatidylinositol 3-kinase complex#GO:0005942;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;membrane#GO:0016020;transferase complex, transferring phosphorus-containing groups#GO:0061695;extrinsic component of membrane#GO:0019898 kinase modulator#PC00140 HELRO|EnsemblGenome=HelroG189841|UniProtKB=T1FRE9 T1FRE9 20211396 PTHR21522:SF68 PROTON CHANNEL OTOP G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078;proton channel activity#GO:0015252;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;proton transmembrane transport#GO:1902600;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG90848|UniProtKB=T1G7W9 T1G7W9 20217166 PTHR11732:SF506 ALDO/KETO REDUCTASE ALDO-KETO REDUCTASE 1B, ISOFORM C-RELATED oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 reductase#PC00198;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG185672|UniProtKB=T1FN46 T1FN46 20210244 PTHR18952:SF141 CARBONIC ANHYDRASE CARBONIC ANHYDRASE carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG136695|UniProtKB=T1EIF3 T1EIF3 20196353 PTHR11644:SF2 CYTIDINE DEAMINASE CYTIDINE DEAMINASE cation binding#GO:0043169;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;metal ion binding#GO:0046872;deaminase activity#GO:0019239;ion binding#GO:0043167 cellular aromatic compound metabolic process#GO:0006725;nucleoside metabolic process#GO:0009116;glycosyl compound catabolic process#GO:1901658;carbohydrate derivative metabolic process#GO:1901135;heterocycle catabolic process#GO:0046700;pyrimidine-containing compound metabolic process#GO:0072527;organonitrogen compound catabolic process#GO:1901565;nucleobase-containing compound metabolic process#GO:0006139;cellular nitrogen compound catabolic process#GO:0044270;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;nucleoside catabolic process#GO:0009164;organic substance catabolic process#GO:1901575;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;cellular catabolic process#GO:0044248;heterocycle metabolic process#GO:0046483;carbohydrate derivative catabolic process#GO:1901136;cellular metabolic process#GO:0044237;organonitrogen compound metabolic process#GO:1901564;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;small molecule catabolic process#GO:0044282;aromatic compound catabolic process#GO:0019439;nucleobase-containing small molecule catabolic process#GO:0034656;organic cyclic compound catabolic process#GO:1901361;nucleobase-containing compound catabolic process#GO:0034655;glycosyl compound metabolic process#GO:1901657;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 deaminase#PC00088;hydrolase#PC00121 Salvage pyrimidine ribonucleotides#P02775>Cytidine deaminase#P03154;Salvage pyrimidine deoxyribonucleotides#P02774>Cytidine deaminase#P03144;Pyrimidine Metabolism#P02771>Cytidine Deaminase#P03130 HELRO|EnsemblGenome=HelroG68923|UniProtKB=T1FZL7 T1FZL7 20214265 PTHR13622:SF8 THIAMIN PYROPHOSPHOKINASE THIAMIN PYROPHOSPHOKINASE 1 kinase#PC00137 Thiamin metabolism#P02780>Thiamine kinase#P03176 HELRO|EnsemblGenome=HelroG178769|UniProtKB=T1FDP8 T1FDP8 20206947 PTHR33332:SF48 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161686|UniProtKB=T1ERS6 T1ERS6 20199276 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG185982|UniProtKB=T1FNI6 T1FNI6 20210383 PTHR11141:SF0 PROTEIN TRANSPORT PROTEIN SEC23 PROTEIN TRANSPORT PROTEIN SEC23 nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;membrane organization#GO:0061024;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;vesicle budding from membrane#GO:0006900;organelle organization#GO:0006996;COPII-coated vesicle budding#GO:0090114;establishment of localization in cell#GO:0051649;vesicle organization#GO:0016050;intracellular transport#GO:0046907 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;ER to Golgi transport vesicle membrane#GO:0012507;endoplasmic reticulum exit site#GO:0070971;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;vesicle coat#GO:0030120;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;transport vesicle membrane#GO:0030658;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane coat#GO:0030117;coated vesicle membrane#GO:0030662;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;coated membrane#GO:0048475;cytoplasmic vesicle membrane#GO:0030659;endoplasmic reticulum#GO:0005783 vesicle coat protein#PC00235 HELRO|EnsemblGenome=HelroG156728|UniProtKB=T1EM04 T1EM04 20197604 PTHR11805:SF1 CYSTEINE-RICH PDZ-BINDING PROTEIN CYSTEINE-RICH PDZ-BINDING PROTEIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;microtubule binding#GO:0008017;tubulin binding#GO:0015631;binding#GO:0005488 cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987;cytoplasmic microtubule organization#GO:0031122 HELRO|EnsemblGenome=HelroG181382|UniProtKB=T1FGY1 T1FGY1 20208080 PTHR22802:SF463 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG177878|UniProtKB=T1FCE7 T1FCE7 20206496 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG178674|UniProtKB=T1FDJ9 T1FDJ9 20206898 PTHR10270:SF161 SOX TRANSCRIPTION FACTOR SEX-DETERMINING REGION Y PROTEIN DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;cell differentiation#GO:0030154;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG65269|UniProtKB=T1FY52 T1FY52 20213750 PTHR12086:SF9 EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN EF-HAND DOMAIN-CONTAINING PROTEIN 1 cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;tubulin binding#GO:0015631;alpha-tubulin binding#GO:0043014;binding#GO:0005488 cell division#GO:0051301;mitotic spindle organization#GO:0007052;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;cilium or flagellum-dependent cell motility#GO:0001539;cell motility#GO:0048870;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;cilium-dependent cell motility#GO:0060285;mitotic cytokinesis#GO:0000281;mitotic cell cycle#GO:0000278;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cytoskeleton-dependent cytokinesis#GO:0061640;cell cycle#GO:0007049;cytoskeleton organization#GO:0007010;spindle organization#GO:0007051;cytokinesis#GO:0000910 axoneme#GO:0005930;cytoplasmic region#GO:0099568;cellular anatomical entity#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;mitotic spindle#GO:0072686;microtubule cytoskeleton#GO:0015630;ciliary plasm#GO:0097014;plasma membrane bounded cell projection cytoplasm#GO:0032838;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;cell projection#GO:0042995;cilium#GO:0005929;spindle#GO:0005819 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG185319|UniProtKB=T1FMN6 T1FMN6 20210085 PTHR12277:SF72 ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN BAT5L PROTEIN hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;phospholipase activity#GO:0004620;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;neutral lipid catabolic process#GO:0046461;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;glycerophospholipid metabolic process#GO:0006650;glycerolipid catabolic process#GO:0046503;lipid catabolic process#GO:0016042;glycerophospholipid catabolic process#GO:0046475;phospholipid metabolic process#GO:0006644;cellular process#GO:0009987;acylglycerol metabolic process#GO:0006639;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate catabolic process#GO:0046434;acylglycerol catabolic process#GO:0046464;phosphate-containing compound metabolic process#GO:0006796;neutral lipid metabolic process#GO:0006638;glycerolipid metabolic process#GO:0046486;nitrogen compound metabolic process#GO:0006807;cellular modified amino acid metabolic process#GO:0006575;phospholipid catabolic process#GO:0009395;catabolic process#GO:0009056;organophosphate metabolic process#GO:0019637;organic substance catabolic process#GO:1901575;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248 cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG182201|UniProtKB=T1FHX2 T1FHX2 20208421 PTHR15036:SF85 PIKACHURIN-LIKE PROTEIN SP2353, ISOFORM A cell adhesion molecule#PC00069 HELRO|EnsemblGenome=HelroG156791|UniProtKB=T1EM11 T1EM11 20197611 PTHR11945:SF23 MADS BOX PROTEIN MYOCYTE-SPECIFIC ENHANCER FACTOR 2D sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;cell differentiation#GO:0030154;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 MADS box transcription factor#PC00250 CCKR signaling map#P06959>MEF2D#P07048;p38 MAPK pathway#P05918>MEF#P06023;CCKR signaling map#P06959>MEF2#P07032 HELRO|EnsemblGenome=HelroG173514|UniProtKB=T1F6X1 T1F6X1 20204570 PTHR10884:SF14 NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3 NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG183270|UniProtKB=T1FJE2 T1FJE2 20208941 PTHR16019:SF5 SYNAPSE-ASSOCIATED PROTEIN BSD DOMAIN-CONTAINING PROTEIN 1 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG109416|UniProtKB=T1EET6 T1EET6 20195088 PTHR22780:SF4 ADAPTIN, ALPHA/GAMMA/EPSILON AP-2 COMPLEX SUBUNIT ALPHA molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 localization#GO:0051179;establishment of localization#GO:0051234;clathrin-dependent endocytosis#GO:0072583;transport#GO:0006810;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;receptor-mediated endocytosis#GO:0006898;cellular process#GO:0009987;import into cell#GO:0098657 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;plasma membrane protein complex#GO:0098797;clathrin vesicle coat#GO:0030125;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;vesicle coat#GO:0030120;intracellular anatomical structure#GO:0005622;AP-type membrane coat adaptor complex#GO:0030119;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;clathrin-coated vesicle#GO:0030136;endomembrane system#GO:0012505;membrane coat#GO:0030117;coated vesicle membrane#GO:0030662;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;coated membrane#GO:0048475;endocytic vesicle#GO:0030139;cytoplasmic vesicle membrane#GO:0030659;clathrin-coated pit#GO:0005905;plasma membrane#GO:0005886 membrane traffic protein#PC00150 Huntington disease#P00029>alpha-Adaptin#P00782 HELRO|EnsemblGenome=HelroG161916|UniProtKB=T1ES15 T1ES15 20199365 PTHR15577:SF2 ZINC FINGER CONTAINING PROTEIN ZINC FINGER PROTEIN 318 positive regulation of nitrogen compound metabolic process#GO:0051173;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of RNA metabolic process#GO:0051253;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of cellular metabolic process#GO:0031325;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;negative regulation of DNA-templated transcription#GO:0045892;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;regulation of DNA-templated transcription#GO:0006355;negative regulation of metabolic process#GO:0009892;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185540|UniProtKB=T1FMY3 T1FMY3 20210182 PTHR43238:SF1 GDP-L-FUCOSE SYNTHASE GDP-L-FUCOSE SYNTHASE oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG159293|UniProtKB=T1ENU6 T1ENU6 20198246 PTHR24256:SF571 TRYPTASE-RELATED PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN hydrolase activity#GO:0016787;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG116728|UniProtKB=T1EGH3 T1EGH3 20195675 PTHR10778:SF4 SOLUTE CARRIER FAMILY 35 MEMBER B NUCLEOTIDE SUGAR TRANSPORTER SLC35B4 carbohydrate derivative transmembrane transporter activity#GO:1901505;nucleobase-containing compound transmembrane transporter activity#GO:0015932;transmembrane transporter activity#GO:0022857;nucleotide-sugar transmembrane transporter activity#GO:0005338;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215 localization#GO:0051179;organic substance transport#GO:0071702;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;organic anion transport#GO:0015711;nucleobase-containing compound transport#GO:0015931;nucleotide-sugar transmembrane transport#GO:0015780;transport#GO:0006810;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264 bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;Golgi membrane#GO:0000139;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG186226|UniProtKB=T1FNU3 T1FNU3 20210490 PTHR10827:SF52 RETICULOCALBIN IP16409P cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG80515|UniProtKB=T1G416 T1G416 20215814 PTHR45798:SF97 RING-H2 FINGER PROTEIN ATL61-RELATED-RELATED ALCOHOL-SENSITIVE RING FINGER PROTEIN 1 HELRO|EnsemblGenome=HelroG180449|UniProtKB=T1FFX7 T1FFX7 20207726 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG115966|UniProtKB=T1EGC1 T1EGC1 20195623 PTHR23354:SF122 NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED GTPASE-ACTIVATING PROTEIN SKYWALKER HELRO|EnsemblGenome=HelroG163610|UniProtKB=T1EUA1 T1EUA1 20200151 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG94029|UniProtKB=T1G8Y6 T1G8Y6 20217533 PTHR48102:SF7 ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887;pyrophosphatase activity#GO:0016462;ATP-dependent activity#GO:0140657;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;anion binding#GO:0043168;ion binding#GO:0043167;ATP binding#GO:0005524 macromolecule catabolic process#GO:0009057;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;proteolysis#GO:0006508;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;catabolic process#GO:0009056;organonitrogen compound catabolic process#GO:1901565;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;primary metabolic process#GO:0044238 protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG85971|UniProtKB=T1G652 T1G652 20216549 PTHR11533:SF299 PROTEASE M1 ZINC METALLOPROTEASE AMINOPEPTIDASE metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;amide binding#GO:0033218;metal ion binding#GO:0046872;peptidase activity#GO:0008233;metalloaminopeptidase activity#GO:0070006;cation binding#GO:0043169;peptide binding#GO:0042277;hydrolase activity#GO:0016787;aminopeptidase activity#GO:0004177;exopeptidase activity#GO:0008238;ion binding#GO:0043167;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;peptide catabolic process#GO:0043171;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;membrane#GO:0016020;extracellular region#GO:0005576;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG115704|UniProtKB=T1EGA1 T1EGA1 20195603 PTHR11909:SF428 CASEIN KINASE-RELATED CASEIN KINASE I ISOFORM EPSILON transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of protein metabolic process#GO:0051246;regulation of catabolic process#GO:0009894;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of signal transduction#GO:0009967;regulation of proteolysis involved in protein catabolic process#GO:1903050;positive regulation of proteolysis#GO:0045862;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;regulation of signal transduction#GO:0009966;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;organic substance metabolic process#GO:0071704;positive regulation of proteolysis involved in protein catabolic process#GO:1903052;macromolecule metabolic process#GO:0043170;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cellular metabolic process#GO:0044237;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;cell communication#GO:0007154;positive regulation of macromolecule metabolic process#GO:0010604;primary metabolic process#GO:0044238;positive regulation of cellular process#GO:0048522;positive regulation of canonical Wnt signaling pathway#GO:0090263;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of catabolic process#GO:0009896;positive regulation of protein catabolic process#GO:0045732;import into cell#GO:0098657;regulation of metabolic process#GO:0019222;positive regulation of nitrogen compound metabolic process#GO:0051173;signal transduction#GO:0007165;macromolecule modification#GO:0043412;regulation of signaling#GO:0023051;transport#GO:0006810;positive regulation of proteasomal protein catabolic process#GO:1901800;protein modification process#GO:0036211;regulation of protein catabolic process#GO:0042176;peptidyl-amino acid modification#GO:0018193;positive regulation of Wnt signaling pathway#GO:0030177;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;positive regulation of response to stimulus#GO:0048584;positive regulation of metabolic process#GO:0009893;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;signaling#GO:0023052;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;metabolic process#GO:0008152;regulation of cell communication#GO:0010646;regulation of proteolysis#GO:0030162;cellular response to stimulus#GO:0051716;organonitrogen compound metabolic process#GO:1901564;protein phosphorylation#GO:0006468;cellular process#GO:0009987;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of proteasomal protein catabolic process#GO:0061136;regulation of primary metabolic process#GO:0080090;localization#GO:0051179;response to stimulus#GO:0050896;positive regulation of protein metabolic process#GO:0051247;regulation of macromolecule metabolic process#GO:0060255;regulation of Wnt signaling pathway#GO:0030111;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;CCKR signaling map#P06959>CK1delta/epsilon#P07089;Hedgehog signaling pathway#P00025>Casein kinase I#P00681;Circadian clock system#P00015>Casein kinase I#P00502;Parkinson disease#P00049>Casein kinase I#P01242 HELRO|EnsemblGenome=HelroG176814|UniProtKB=T1FAX8 T1FAX8 20205977 PTHR16220:SF0 WD REPEAT PROTEIN 8-RELATED WD REPEAT-CONTAINING PROTEIN WRAP73 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;nuclear chromosome segregation#GO:0098813;mitotic spindle organization#GO:0007052;sister chromatid segregation#GO:0000819;nuclear division#GO:0000280;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047;chromosome segregation#GO:0007059;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;microtubule-based process#GO:0007017;organelle organization#GO:0006996;chromosome organization#GO:0051276;mitotic spindle assembly#GO:0090307;spindle assembly#GO:0051225;cell cycle#GO:0007049;mitotic nuclear division#GO:0140014;organelle fission#GO:0048285;cytoskeleton organization#GO:0007010;spindle organization#GO:0007051;mitotic sister chromatid segregation#GO:0000070;non-membrane-bounded organelle assembly#GO:0140694 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG95740|UniProtKB=T1G972 T1G972 20217619 PTHR10554:SF12 SYNTROPHIN IP02644P membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;plasma membrane protein complex#GO:0098797;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG104861|UniProtKB=T1EDP0 T1EDP0 20194692 PTHR16515:SF19 PR DOMAIN ZINC FINGER PROTEIN PR DOMAIN ZINC FINGER PROTEIN 14 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG173693|UniProtKB=T1F746 T1F746 20204645 PTHR31780:SF10 STRESS RESPONSE PROTEIN NST1-RELATED LD36051P HELRO|EnsemblGenome=HelroG179276|UniProtKB=T1FEG9 T1FEG9 20207218 PTHR21461:SF69 GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824 glycosylation#GO:0070085;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG159579|UniProtKB=T1EP67 T1EP67 20198367 PTHR23107:SF34 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN HTH LA-TYPE RNA-BINDING DOMAIN-CONTAINING PROTEIN transcription coactivator activity#GO:0003713;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG91145|UniProtKB=T1G802 T1G802 20217199 PTHR13336:SF3 OVARIAN CARCINOMA IMMUNOREACTIVE ANTIGEN OCIA DOMAIN-CONTAINING PROTEIN 1 cytoplasm#GO:0005737;endosome#GO:0005768;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG192824|UniProtKB=T1FUC2 T1FUC2 20212418 PTHR48153:SF4 UFM1-SPECIFIC PROTEASE 2 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MUG105 cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG192019|UniProtKB=T1FTI4 T1FTI4 20212131 PTHR24416:SF623 TYROSINE-PROTEIN KINASE RECEPTOR PROTEIN KINASE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG189860|UniProtKB=T1FRF4 T1FRF4 20211401 PTHR13832:SF827 PROTEIN PHOSPHATASE 2C PROTEIN PHOSPHATASE 1L macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;dephosphorylation#GO:0016311;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG183224|UniProtKB=T1FJC2 T1FJC2 20208921 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG194973|UniProtKB=T1FWM1 T1FWM1 20213216 PTHR15463:SF2 AP1 GAMMA SUBUNIT BINDING PROTEIN 1 SYNERGIN GAMMA bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;clathrin vesicle coat#GO:0030125;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;vesicle membrane#GO:0012506;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;vesicle coat#GO:0030120;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;transport vesicle membrane#GO:0030658;Golgi-associated vesicle membrane#GO:0030660;clathrin-coated vesicle#GO:0030136;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane coat#GO:0030117;coated vesicle membrane#GO:0030662;membrane-bounded organelle#GO:0043227;Golgi-associated vesicle#GO:0005798;cytoplasmic vesicle#GO:0031410;transport vesicle#GO:0030133;coated membrane#GO:0048475;cytoplasmic vesicle membrane#GO:0030659;trans-Golgi network transport vesicle#GO:0030140 HELRO|EnsemblGenome=HelroG143271|UniProtKB=T1EJ98 T1EJ98 20196648 PTHR46010:SF1 PROTEIN IWS1 HOMOLOG PROTEIN IWS1 HOMOLOG poly(A)+ mRNA export from nucleus#GO:0016973;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;mRNA transport#GO:0051028;RNA localization#GO:0006403;localization#GO:0051179;organic substance transport#GO:0071702;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG62880|UniProtKB=T1FX65 T1FX65 20213413 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG69589|UniProtKB=T1FZW9 T1FZW9 20214367 PTHR12345:SF3 SYNTENIN RELATED PDZ DOMAIN-CONTAINING PROTEIN cytoplasm#GO:0005737;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG164897|UniProtKB=T1EVX9 T1EVX9 20200729 PTHR33273:SF4 DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG172670|UniProtKB=T1F5R7 T1F5R7 20204166 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG96436|UniProtKB=T1G9C1 T1G9C1 20217668 PTHR22878:SF63 DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED DYNEIN AXONEMAL HEAVY CHAIN 10 Huntington disease#P00029>Dynein complex#P00774 HELRO|EnsemblGenome=HelroG73116|UniProtKB=T1G1A4 T1G1A4 20214852 PTHR13229:SF2 PROTEIN KISH-A PROTEIN KISH-A-RELATED cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;protein secretion#GO:0009306;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;establishment of protein localization to extracellular region#GO:0035592;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;secretion#GO:0046903;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;protein localization to extracellular region#GO:0071692;export from cell#GO:0140352;secretion by cell#GO:0032940 HELRO|EnsemblGenome=HelroG138770|UniProtKB=T1EIX5 T1EIX5 20196525 PTHR28520:SF2 MITOTIC-SPINDLE ORGANIZING PROTEIN 1 MITOTIC-SPINDLE ORGANIZING PROTEIN 1 cellular component biogenesis#GO:0044085;mitotic spindle organization#GO:0007052;nuclear division#GO:0000280;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;protein-containing complex assembly#GO:0065003;microtubule cytoskeleton organization involved in mitosis#GO:1902850;microtubule polymerization or depolymerization#GO:0031109;mitotic cell cycle process#GO:1903047;chromosome segregation#GO:0007059;mitotic cell cycle#GO:0000278;microtubule polymerization#GO:0046785;supramolecular fiber organization#GO:0097435;mitotic spindle assembly#GO:0090307;spindle assembly#GO:0051225;mitotic nuclear division#GO:0140014;cytoskeleton organization#GO:0007010;mitotic sister chromatid segregation#GO:0000070;spindle organization#GO:0007051;non-membrane-bounded organelle assembly#GO:0140694;cellular component assembly#GO:0022607;nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;cellular component organization#GO:0016043;cellular process#GO:0009987;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;chromosome organization#GO:0051276;organelle organization#GO:0006996;protein polymerization#GO:0051258;cell cycle#GO:0007049;organelle fission#GO:0048285;microtubule nucleation#GO:0007020 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;spindle#GO:0005819;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG111022|UniProtKB=T1EF71 T1EF71 20195223 PTHR45919:SF1 GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE mannosyltransferase activity#GO:0000030;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;cellular lipid metabolic process#GO:0044255;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG189320|UniProtKB=T1FQY3 T1FQY3 20211230 PTHR13693:SF102 CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE 2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL transaminase#PC00216;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG100536|UniProtKB=T1ED02 T1ED02 20194454 PTHR45664:SF12 PROTEIN ZERKNUELLT 1-RELATED PANCREAS_DUODENUM HOMEOBOX PROTEIN 1 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG174094|UniProtKB=T1F7L5 T1F7L5 20204814 PTHR23257:SF706 SERINE-THREONINE PROTEIN KINASE PROTO-ONCOGENE SERINE_THREONINE-PROTEIN KINASE MOS transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG131960|UniProtKB=T1EHW9 T1EHW9 20196169 PTHR13233:SF0 MICROSPHERULE PROTEIN 1 MICROSPHERULE PROTEIN 1 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;chromosome#GO:0005694 HELRO|EnsemblGenome=HelroG89193|UniProtKB=T1G799 T1G799 20216946 PTHR45630:SF8 CATION-TRANSPORTING ATPASE-RELATED CATION-TRANSPORTING ATPASE transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;active monoatomic ion transmembrane transporter activity#GO:0022853;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation transmembrane transporter activity#GO:0008324 localization#GO:0051179;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG133665|UniProtKB=T1EI22 T1EI22 20196222 PTHR15750:SF2 VASOHIBIN-1-LIKE ISOFORM X2 VASOHIBIN HELRO|EnsemblGenome=HelroG162969|UniProtKB=T1ETG4 T1ETG4 20199864 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG176859|UniProtKB=T1FAZ6 T1FAZ6 20205995 PTHR33604:SF3 OSJNBA0004B13.7 PROTEIN OSJNBA0004B13.7 PROTEIN HELRO|EnsemblGenome=HelroG176383|UniProtKB=T1FAG7 T1FAG7 20205816 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG162815|UniProtKB=T1ET75 T1ET75 20199775 PTHR11850:SF295 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS ACHINTYA, ISOFORM C-RELATED DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG185638|UniProtKB=T1FN27 T1FN27 20210226 PTHR43294:SF13 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium ion transmembrane transporter activity#GO:0015079;sodium ion transmembrane transporter activity#GO:0015081;P-type ion transporter activity#GO:0015662;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075 inorganic ion homeostasis#GO:0098771;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;proton transmembrane transport#GO:1902600;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;sodium ion homeostasis#GO:0055078;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;import into cell#GO:0098657;monoatomic cation transmembrane transport#GO:0098655;export from cell#GO:0140352;sodium ion transmembrane transport#GO:0035725;potassium ion import across plasma membrane#GO:1990573;potassium ion transport#GO:0006813 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG158326|UniProtKB=T1EMN6 T1EMN6 20197836 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG173977|UniProtKB=T1F7F8 T1F7F8 20204757 PTHR33332:SF48 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG110575|UniProtKB=T1EF33 T1EF33 20195185 PTHR47958:SF24 ATP-DEPENDENT RNA HELICASE DBP3 RNA HELICASE catalytic activity, acting on RNA#GO:0140098;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640;mRNA binding#GO:0003729 membrane-enclosed lumen#GO:0031974;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG177262|UniProtKB=T1FBF2 T1FBF2 20206151 PTHR19282:SF544 TETRASPANIN TETRASPANIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG194398|UniProtKB=T1FW07 T1FW07 20213003 PTHR15081:SF1 NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED NUCLEAR AUTOANTIGENIC SPERM PROTEIN protein binding#GO:0005515;binding#GO:0005488;histone binding#GO:0042393 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-DNA complex organization#GO:0071824;organelle organization#GO:0006996;chromosome organization#GO:0051276;protein-containing complex organization#GO:0043933;protein-containing complex assembly#GO:0065003;chromatin organization#GO:0006325;cellular component organization#GO:0016043;cellular process#GO:0009987;chromatin remodeling#GO:0006338;protein-DNA complex assembly#GO:0065004 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG80426|UniProtKB=T1G405 T1G405 20215803 PTHR13318:SF257 PARTNER OF PAIRED, ISOFORM B-RELATED F-BOX DOMAIN-CONTAINING PROTEIN macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234 HELRO|EnsemblGenome=HelroG85938|UniProtKB=T1G647 T1G647 20216544 PTHR11800:SF2 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;RNA polymerase activity#GO:0097747;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388;General transcription regulation#P00023>RNA Polymerase II#P00660 HELRO|EnsemblGenome=HelroG90523|UniProtKB=T1G7S5 T1G7S5 20217122 PTHR48027:SF18 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED HELRO|EnsemblGenome=HelroG101736|UniProtKB=T1ED66 T1ED66 20194518 PTHR10799:SF879 SNF2/RAD54 HELICASE FAMILY CHROMATIN-REMODELING COMPLEX ATPASE CHAIN ISWI ATP-dependent activity, acting on DNA#GO:0008094;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on DNA#GO:0140097 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;chromosome#GO:0005694;chromatin#GO:0000785;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA helicase#PC00011;DNA metabolism protein#PC00009 Wnt signaling pathway#P00057>SWI/SNF#P01435 HELRO|EnsemblGenome=HelroG110370|UniProtKB=T1EF18 T1EF18 20195170 PTHR44156:SF6 SUPERNUMERARY LIMBS, ISOFORM B-RELATED DYNEIN ASSEMBLY FACTOR WITH WDR REPEAT DOMAINS 1 HELRO|EnsemblGenome=HelroG158915|UniProtKB=T1ENE3 T1ENE3 20198093 PTHR24126:SF14 ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED ANK_REP_REGION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG160122|UniProtKB=T1EPU1 T1EPU1 20198591 PTHR47763:SF1 ALPHA-PROTEIN KINASE VWKA DUF659 DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-serine modification#GO:0018209;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG101134|UniProtKB=T1ED31 T1ED31 20194483 PTHR12093:SF10 NCK-ASSOCIATED PROTEIN 1 MEMBRANE-ASSOCIATED PROTEIN HEM cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cell projection organization#GO:0030030;developmental process#GO:0032502;cell morphogenesis#GO:0000902;cellular component organization#GO:0016043;cell motility#GO:0048870;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;anatomical structure morphogenesis#GO:0009653;organelle organization#GO:0006996;anatomical structure development#GO:0048856;cortical cytoskeleton organization#GO:0030865;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cell migration#GO:0016477;cortical actin cytoskeleton organization#GO:0030866 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG189070|UniProtKB=T1FQM0 T1FQM0 20211117 PTHR22760:SF4 GLYCOSYLTRANSFERASE GPI MANNOSYLTRANSFERASE 3 mannosyltransferase activity#GO:0000030;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 lipid metabolic process#GO:0006629;carbohydrate derivative metabolic process#GO:1901135;phospholipid biosynthetic process#GO:0008654;macromolecule modification#GO:0043412;phosphatidylinositol biosynthetic process#GO:0006661;organophosphate biosynthetic process#GO:0090407;glycolipid metabolic process#GO:0006664;protein modification process#GO:0036211;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;glycerolipid biosynthetic process#GO:0045017;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;organic substance biosynthetic process#GO:1901576;liposaccharide metabolic process#GO:1903509;cellular process#GO:0009987;membrane lipid biosynthetic process#GO:0046467;GPI anchor metabolic process#GO:0006505;lipoprotein biosynthetic process#GO:0042158;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;GPI anchor biosynthetic process#GO:0006506;membrane lipid metabolic process#GO:0006643;glycerophospholipid biosynthetic process#GO:0046474;glycolipid biosynthetic process#GO:0009247;organophosphate metabolic process#GO:0019637;lipoprotein metabolic process#GO:0042157;cellular lipid metabolic process#GO:0044255 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;endoplasmic reticulum membrane#GO:0005789 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG145168|UniProtKB=T1EJJ1 T1EJJ1 20196741 PTHR45880:SF1 RNA-BINDING MOTIF PROTEIN, X-LINKED 2 RNA-BINDING MOTIF PROTEIN, X-LINKED 2 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 catalytic step 2 spliceosome#GO:0071013;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;U2 snRNP#GO:0005686;membrane-bounded organelle#GO:0043227;precatalytic spliceosome#GO:0071011;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG193162|UniProtKB=T1FUP2 T1FUP2 20212538 PTHR15189:SF7 BRISC AND BRCA1-A COMPLEX MEMBER 2 BRISC AND BRCA1-A COMPLEX MEMBER 2 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;DNA damage response#GO:0006974;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;BRCA1-A complex#GO:0070531;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG169371|UniProtKB=T1F1V1 T1F1V1 20202801 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG86767|UniProtKB=T1G6G8 T1G6G8 20216665 PTHR19818:SF163 ZINC FINGER PROTEIN ZIC AND GLI C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG193727|UniProtKB=T1FVA7 T1FVA7 20212753 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG180065|UniProtKB=T1FFF6 T1FFF6 20207555 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG189974|UniProtKB=T1FRJ8 T1FRJ8 20211445 PTHR12630:SF6 N-LINKED OLIGOSACCHARIDE PROCESSING N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNIT GAMMA carbohydrate derivative metabolic process#GO:1901135;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;endoplasmic reticulum protein-containing complex#GO:0140534;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;catalytic complex#GO:1902494;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG189105|UniProtKB=T1FQN6 T1FQN6 20211133 PTHR21359:SF1 DUF5577 DOMAIN-CONTAINING PROTEIN DUF5577 DOMAIN-CONTAINING PROTEIN membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG183643|UniProtKB=T1FJZ4 T1FJZ4 20209143 PTHR18945:SF865 NEUROTRANSMITTER GATED ION CHANNEL NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA7, ISOFORM E ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG173257|UniProtKB=T1F6L9 T1F6L9 20204468 PTHR45627:SF16 ADENYLATE CYCLASE TYPE 1 ADENYLATE CYCLASE adenylate cyclase activity#GO:0004016;lyase activity#GO:0016829;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824 regulation of biological process#GO:0050789;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 cyclase#PC00079;adenylate cyclase#PC00043;lyase#PC00144 HELRO|EnsemblGenome=HelroG183195|UniProtKB=T1FJA2 T1FJA2 20208901 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG173812|UniProtKB=T1F795 T1F795 20204694 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG87810|UniProtKB=T1G6V7 T1G6V7 20216804 PTHR45695:SF23 LEUCOKININ RECEPTOR-RELATED GALANIN-LIKE G-PROTEIN COUPLED RECEPTOR NPR-9 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG62561|UniProtKB=T1FX24 T1FX24 20213372 PTHR12064:SF94 METAL TRANSPORTER CNNM UNEXTENDED PROTEIN ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG105779|UniProtKB=T1EDX6 T1EDX6 20194778 PTHR46342:SF1 ALPHA-CATULIN ALPHA-CATULIN regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signaling#GO:0023052;Rho protein signal transduction#GO:0007266 Wnt signaling pathway#P00057>alpha-catenin#P01471 HELRO|EnsemblGenome=HelroG192864|UniProtKB=T1FUD5 T1FUD5 20212431 PTHR45857:SF4 FORMIN-LIKE PROTEIN FORMIN-LIKE PROTEIN HELRO|EnsemblGenome=HelroG74348|UniProtKB=T1G1P8 T1G1P8 20214996 PTHR24246:SF27 OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR ADENOSINE RECEPTOR, ISOFORM A G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HELRO|EnsemblGenome=HelroG64508|UniProtKB=T1FXV7 T1FXV7 20213655 PTHR18934:SF119 ATP-DEPENDENT RNA HELICASE ATP-DEPENDENT RNA HELICASE A nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640 cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG91786|UniProtKB=T1G889 T1G889 20217286 PTHR23339:SF27 TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE PROTEIN-TYROSINE-PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 regulation of mitotic cell cycle phase transition#GO:1901990;microtubule cytoskeleton organization#GO:0000226;regulation of cell cycle phase transition#GO:1901987;positive regulation of cell cycle#GO:0045787;cellular component organization#GO:0016043;regulation of cell division#GO:0051302;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;regulation of cell cycle process#GO:0010564;regulation of biological process#GO:0050789;positive regulation of cell division#GO:0051781;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;positive regulation of cell cycle process#GO:0090068;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of cell cycle#GO:0051726;regulation of cytokinesis#GO:0032465;regulation of mitotic cell cycle#GO:0007346;positive regulation of biological process#GO:0048518 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG157348|UniProtKB=T1EM99 T1EM99 20197699 PTHR10176:SF3 GLYCOGEN SYNTHASE GLYCOGEN [STARCH] SYNTHASE UDP-glucosyltransferase activity#GO:0035251;transferase activity#GO:0016740;glucosyltransferase activity#GO:0046527;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758 glucan metabolic process#GO:0044042;carbohydrate biosynthetic process#GO:0016051;macromolecule biosynthetic process#GO:0009059;polysaccharide biosynthetic process#GO:0000271;macromolecule metabolic process#GO:0043170;glycogen metabolic process#GO:0005977;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;glycogen biosynthetic process#GO:0005978;energy derivation by oxidation of organic compounds#GO:0015980;primary metabolic process#GO:0044238;polysaccharide metabolic process#GO:0005976;glucan biosynthetic process#GO:0009250;energy reserve metabolic process#GO:0006112;carbohydrate metabolic process#GO:0005975;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG180180|UniProtKB=T1FFJ7 T1FFJ7 20207596 PTHR45775:SF6 RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C HELRO|EnsemblGenome=HelroG173801|UniProtKB=T1F788 T1F788 20204687 PTHR21600:SF40 MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE PSEUDOURIDYLATE SYNTHASE RPUSD2 isomerase activity#GO:0016853;intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA modification#GO:0009451;rRNA modification#GO:0000154;RNA processing#GO:0006396;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;ribosome biogenesis#GO:0042254;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;pseudouridine synthesis#GO:0001522;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG169786|UniProtKB=T1F2B6 T1F2B6 20202966 PTHR46478:SF1 VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3A VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3A HELRO|EnsemblGenome=HelroG184933|UniProtKB=T1FM65 T1FM65 20209914 PTHR12027:SF112 WNT RELATED PROTEIN WNT-2 molecular function activator activity#GO:0140677;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;protein binding#GO:0005515;cytokine activity#GO:0005125;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;neurogenesis#GO:0022008;developmental process#GO:0032502;multicellular organism development#GO:0007275;cell communication#GO:0007154;cell fate commitment#GO:0045165;cell-cell signaling by wnt#GO:0198738;nervous system development#GO:0007399;cellular process#GO:0009987;regulation of biological process#GO:0050789;system development#GO:0048731;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;cell-cell signaling#GO:0007267;signaling#GO:0023052;canonical Wnt signaling pathway#GO:0060070;Wnt signaling pathway#GO:0016055 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Angiogenesis#P00005>Wnt#P00206;Cadherin signaling pathway#P00012>Wnt#P00474 HELRO|EnsemblGenome=HelroG179125|UniProtKB=T1FE73 T1FE73 20207122 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193172|UniProtKB=T1FUP7 T1FUP7 20212543 PTHR46542:SF1 X-BOX BINDING PROTEIN 1 X-BOX BINDING PROTEIN 1 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG186752|UniProtKB=T1FP29 T1FP29 20210576 PTHR24056:SF472 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 4, ISOFORM A transferase activity#GO:0016740;cyclin-dependent protein kinase activity#GO:0097472;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein serine/threonine kinase activity#GO:0004674;protein binding#GO:0005515;cyclin binding#GO:0030332;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 signal transduction#GO:0007165;mitotic cell cycle phase transition#GO:0044772;macromolecule modification#GO:0043412;cell cycle G1/S phase transition#GO:0044843;cell cycle process#GO:0022402;protein modification process#GO:0036211;mitotic cell cycle process#GO:1903047;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;G1/S transition of mitotic cell cycle#GO:0000082;regulation of biological process#GO:0050789;mitotic cell cycle#GO:0000278;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;phosphorylation#GO:0016310;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;response to organic substance#GO:0010033;cellular response to stimulus#GO:0051716;regulation of cell cycle G2/M phase transition#GO:1902749;regulation of mitotic cell cycle phase transition#GO:1901990;macromolecule metabolic process#GO:0043170;regulation of cell cycle phase transition#GO:1901987;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;cell cycle phase transition#GO:0044770;primary metabolic process#GO:0044238;regulation of cell cycle process#GO:0010564;response to stimulus#GO:0050896;regulation of cellular biosynthetic process#GO:0031326;response to chemical#GO:0042221;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of G2/M transition of mitotic cell cycle#GO:0010389;regulation of mitotic cell cycle#GO:0007346;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695 non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG190600|UniProtKB=T1FS44 T1FS44 20211641 PTHR13634:SF0 RIBOSOME BIOGENESIS PROTEIN BRIX RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;organelle assembly#GO:0070925;protein-RNA complex assembly#GO:0022618;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;ribosomal large subunit assembly#GO:0000027;ribonucleoprotein complex biogenesis#GO:0022613;protein-RNA complex organization#GO:0071826;ribosome biogenesis#GO:0042254;non-membrane-bounded organelle assembly#GO:0140694 intracellular non-membrane-bounded organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG178276|UniProtKB=T1FD09 T1FD09 20206708 PTHR24347:SF427 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE DCLK3 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG188893|UniProtKB=T1FQG3 T1FQG3 20211060 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG117169|UniProtKB=T1EGK8 T1EGK8 20195708 PTHR14025:SF20 FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER FANCONI ANEMIA GROUP M PROTEIN DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG180727|UniProtKB=T1FG76 T1FG76 20207825 PTHR13008:SF7 MAP-KINASE ACTIVATING DEATH DOMAIN PROTEIN MADD /DENN/AEX-3 C.ELEGANS MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of apoptotic process#GO:0042981;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;regulation of signaling#GO:0023051;biological regulation#GO:0065007;regulation of intracellular signal transduction#GO:1902531;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of programmed cell death#GO:0043067 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 Apoptosis signaling pathway#P00006>MADD#P00267 HELRO|EnsemblGenome=HelroG120145|UniProtKB=T1EGP6 T1EGP6 20195746 PTHR24345:SF0 SERINE/THREONINE-PROTEIN KINASE PLK CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG104441|UniProtKB=T1EDL7 T1EDL7 20194669 PTHR23153:SF38 UBX-RELATED UBX DOMAIN-CONTAINING PROTEIN 6 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG86856|UniProtKB=T1G6I3 T1G6I3 20216680 PTHR24351:SF249 RIBOSOMAL PROTEIN S6 KINASE PROTEIN KINASE C transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG165535|UniProtKB=T1EWZ3 T1EWZ3 20201093 PTHR46010:SF1 PROTEIN IWS1 HOMOLOG PROTEIN IWS1 HOMOLOG poly(A)+ mRNA export from nucleus#GO:0016973;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;mRNA transport#GO:0051028;RNA localization#GO:0006403;localization#GO:0051179;organic substance transport#GO:0071702;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG89337|UniProtKB=T1G7C3 T1G7C3 20216970 PTHR24349:SF527 SERINE/THREONINE-PROTEIN KINASE LD17393P transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;binding#GO:0005488;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein serine/threonine kinase activity#GO:0004674;protein binding#GO:0005515;calmodulin binding#GO:0005516;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG183330|UniProtKB=T1FJG9 T1FJG9 20208968 PTHR10223:SF0 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4 protein binding#GO:0005515;binding#GO:0005488;polyubiquitin modification-dependent protein binding#GO:0031593;modification-dependent protein binding#GO:0140030 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 peptidase complex#GO:1905368;proteasome accessory complex#GO:0022624;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;proteasome regulatory particle#GO:0005838;catalytic complex#GO:1902494;proteasome complex#GO:0000502;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endopeptidase complex#GO:1905369;membrane-bounded organelle#GO:0043227 protease#PC00190;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489;Cell cycle#P00013>Proteasome#P00480 HELRO|EnsemblGenome=HelroG148404|UniProtKB=T1EK77 T1EK77 20196977 PTHR24333:SF8 HOMEO BOX HB9 LIKE A-RELATED HOMEOBOX PROTEIN CEH-62 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG191631|UniProtKB=T1FT55 T1FT55 20212002 PTHR19324:SF33 PERFORIN-LIKE PROTEIN 1 MUCIN-5AC HELRO|EnsemblGenome=HelroG146310|UniProtKB=T1EJR7 T1EJR7 20196817 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG160914|UniProtKB=T1EQU7 T1EQU7 20198947 PTHR24119:SF10 ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6 SH2 DOMAIN-CONTAINING PROTEIN nucleotide binding#GO:0000166;carbohydrate derivative binding#GO:0097367;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;amide binding#GO:0033218;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;lipid binding#GO:0008289;ion binding#GO:0043167;anion binding#GO:0043168 HELRO|EnsemblGenome=HelroG106017|UniProtKB=T1EDZ2 T1EDZ2 20194794 PTHR45639:SF4 HSC70CB, ISOFORM G-RELATED HSC70CB, ISOFORM G macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 Hsp70 family chaperone#PC00027 HELRO|EnsemblGenome=HelroG172326|UniProtKB=T1F573 T1F573 20203972 PTHR13391:SF0 MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO PROTEIN MISATO HOMOLOG 1 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG190335|UniProtKB=T1FRX0 T1FRX0 20211567 PTHR43358:SF4 ALPHA/BETA-HYDROLASE ALPHA_BETA HYDROLASE FOLD-1 DOMAIN-CONTAINING PROTEIN metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG174804|UniProtKB=T1F8H9 T1F8H9 20205128 PTHR45762:SF3 ZINC FINGER RNA-BINDING PROTEIN ZINC-FINGER PROTEIN AT 72D, ISOFORM B RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG91230|UniProtKB=T1G813 T1G813 20217210 PTHR13832:SF803 PROTEIN PHOSPHATASE 2C PROTEIN PHOSPHATASE 1G macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;dephosphorylation#GO:0016311;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein dephosphorylation#GO:0006470;cellular metabolic process#GO:0044237;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG136779|UniProtKB=T1EIF7 T1EIF7 20196357 PTHR23167:SF46 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED EPS15 HOMOLOGY DOMAIN CONTAINING PROTEIN-BINDING PROTEIN 1, ISOFORM F scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG182508|UniProtKB=T1FIA5 T1FIA5 20208554 PTHR36191:SF8 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG106294|UniProtKB=T1EE15 T1EE15 20194817 PTHR12537:SF12 RNA BINDING PROTEIN PUMILIO-RELATED MATERNAL PROTEIN PUMILIO nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG193153|UniProtKB=T1FUN9 T1FUN9 20212535 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162896|UniProtKB=T1ETC2 T1ETC2 20199822 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180050|UniProtKB=T1FFE4 T1FFE4 20207543 PTHR11412:SF136 MACROGLOBULIN / COMPLEMENT CD109 ANTIGEN protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG115162|UniProtKB=T1EG68 T1EG68 20195570 PTHR10856:SF0 CORONIN CORONIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG69621|UniProtKB=T1FZX3 T1FZX3 20214371 PTHR13720:SF13 WD-40 REPEAT PROTEIN CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 251 membrane-bounded organelle#GO:0043227;motile cilium#GO:0031514;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cilium#GO:0005929;organelle#GO:0043226 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG64842|UniProtKB=T1FY01 T1FY01 20213699 PTHR19338:SF0 TRANSLOCASE OF INNER MITOCHONDRIAL MEMBRANE 13 HOMOLOG MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM13 HELRO|EnsemblGenome=HelroG162248|UniProtKB=T1ESE7 T1ESE7 20199497 PTHR23351:SF24 FOS TRANSCRIPTION FACTOR-RELATED ACTIVATING TRANSCRIPTION FACTOR 3-RELATED DNA-binding transcription factor#PC00218;basic leucine zipper transcription factor#PC00056 HELRO|EnsemblGenome=HelroG83278|UniProtKB=T1G532 T1G532 20216180 PTHR11058:SF9 NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3 NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3 transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;electron transfer activity#GO:0009055;catalytic activity#GO:0003824;oxidoreductase activity, acting on NAD(P)H#GO:0016651;NADH dehydrogenase activity#GO:0003954;active transmembrane transporter activity#GO:0022804;oxidoreductase activity#GO:0016491;transporter activity#GO:0005215 oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;membrane#GO:0016020;NADH dehydrogenase complex#GO:0030964;catalytic complex#GO:1902494 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG95757|UniProtKB=T1G973 T1G973 20217620 PTHR45625:SF4 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1 peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein peptidyl-prolyl isomerization#GO:0000413;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 chaperone#PC00072 HELRO|EnsemblGenome=HelroG105143|UniProtKB=T1EDR4 T1EDR4 20194716 PTHR10778:SF4 SOLUTE CARRIER FAMILY 35 MEMBER B NUCLEOTIDE SUGAR TRANSPORTER SLC35B4 carbohydrate derivative transmembrane transporter activity#GO:1901505;nucleobase-containing compound transmembrane transporter activity#GO:0015932;transmembrane transporter activity#GO:0022857;nucleotide-sugar transmembrane transporter activity#GO:0005338;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215 localization#GO:0051179;organic substance transport#GO:0071702;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;organic anion transport#GO:0015711;nucleobase-containing compound transport#GO:0015931;nucleotide-sugar transmembrane transport#GO:0015780;transport#GO:0006810;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264 bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;Golgi membrane#GO:0000139;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG159478|UniProtKB=T1EP29 T1EP29 20198329 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG102275|UniProtKB=T1ED92 T1ED92 20194544 PTHR43720:SF2 2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE 2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HELRO|EnsemblGenome=HelroG186015|UniProtKB=T1FNJ9 T1FNJ9 20210396 PTHR12411:SF16 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN B cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197 macromolecule catabolic process#GO:0009057;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;proteolysis#GO:0006508;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;catabolic process#GO:0009056;organonitrogen compound catabolic process#GO:1901565;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;lysosome#GO:0005764;intracellular membrane-bounded organelle#GO:0043231;extracellular region#GO:0005576;vacuole#GO:0005773;membrane-bounded organelle#GO:0043227;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;organelle#GO:0043226;lytic vacuole#GO:0000323;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG163344|UniProtKB=T1ETX8 T1ETX8 20200028 PTHR24223:SF454 ATP-BINDING CASSETTE SUB-FAMILY C SUBFAMILY NOT NAMED transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227 HELRO|EnsemblGenome=HelroG163523|UniProtKB=T1EU60 T1EU60 20200110 PTHR31283:SF5 EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER EKC_KEOPS COMPLEX SUBUNIT LAGE3 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;tRNA threonylcarbamoyladenosine metabolic process#GO:0070525;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 protein-containing complex#GO:0032991 HELRO|EnsemblGenome=HelroG163311|UniProtKB=T1ETW4 T1ETW4 20200014 PTHR11188:SF176 ARRESTIN DOMAIN CONTAINING PROTEIN ARRESTIN DOMAIN-CONTAINING PROTEIN 1 localization#GO:0051179;organic substance transport#GO:0071702;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;protein transport#GO:0015031;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG164188|UniProtKB=T1EV27 T1EV27 20200427 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185871|UniProtKB=T1FND6 T1FND6 20210333 PTHR21646:SF16 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2 cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG180890|UniProtKB=T1FGD3 T1FGD3 20207882 PTHR15075:SF2 ALPHA-MANNOSIDE BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE ALPHA-1,6-MANNOSYLGLYCOPROTEIN 6-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE acetylglucosaminyltransferase activity#GO:0008375;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG80480|UniProtKB=T1G415 T1G415 20215813 PTHR12454:SF11 TRIMERIC INTRACELLULAR CATION CHANNEL GH25683P ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG181856|UniProtKB=T1FHE6 T1FHE6 20208245 PTHR10426:SF88 STRICTOSIDINE SYNTHASE-RELATED ADIPOCYTE PLASMA MEMBRANE-ASSOCIATED PROTEIN HEMOMUCIN-RELATED hydrolase activity#GO:0016787;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG193797|UniProtKB=T1FVD1 T1FVD1 20212777 PTHR12955:SF1 SARCOMA ANTIGEN NY-SAR-95-RELATED INTEGRATOR COMPLEX SUBUNIT 13 localization#GO:0051179;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;centrosome localization#GO:0051642;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;integrator complex#GO:0032039;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG175670|UniProtKB=T1F9I1 T1F9I1 20205480 PTHR13866:SF29 SPARC OSTEONECTIN FOLLISTATIN cation binding#GO:0043169;extracellular matrix binding#GO:0050840;small molecule binding#GO:0036094;binding#GO:0005488;collagen binding#GO:0005518;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;protein-containing complex binding#GO:0044877;ion binding#GO:0043167 anatomical structure development#GO:0048856;developmental process#GO:0032502 extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 extracellular matrix glycoprotein#PC00100 HELRO|EnsemblGenome=HelroG167884|UniProtKB=T1EZX2 T1EZX2 20202122 PTHR15545:SF8 PDZ DOMAIN CONTAINING RING FINGER PROTEIN 3, 4 SLO-INTERACTING PROTEIN 1 HELRO|EnsemblGenome=HelroG193074|UniProtKB=T1FUL6 T1FUL6 20212512 PTHR45710:SF26 C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 180 RH26557P defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG160108|UniProtKB=T1EPT1 T1EPT1 20198581 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG171186|UniProtKB=T1F3W9 T1F3W9 20203518 PTHR44755:SF8 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide hormone binding#GO:0017046;hormone binding#GO:0042562;binding#GO:0005488;peptide binding#GO:0042277;amide binding#GO:0033218 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG185206|UniProtKB=T1FMI3 T1FMI3 20210032 PTHR43888:SF31 DNAJ-LIKE-2, ISOFORM A-RELATED DNAJ HOMOLOG SUBFAMILY A MEMBER 2 protein binding#GO:0005515;protein-folding chaperone binding#GO:0051087;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HELRO|EnsemblGenome=HelroG84353|UniProtKB=T1G5H8 T1G5H8 20216325 PTHR23105:SF101 RIBOSOMAL PROTEIN L7AE FAMILY MEMBER LARGE RIBOSOMAL SUBUNIT PROTEIN UL1 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202 HELRO|EnsemblGenome=HelroG124011|UniProtKB=T1EGZ9 T1EGZ9 20195849 PTHR10390:SF61 HOMEOBOX PROTEIN SIX HOMEOBOX PROTEIN SIX2 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG66410|UniProtKB=T1FYK8 T1FYK8 20213906 PTHR21530:SF7 PHEROMONE SHUTDOWN PROTEIN TRAB DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG64824|UniProtKB=T1FXZ8 T1FXZ8 20213696 PTHR12645:SF0 ALR/ERV FAD-LINKED SULFHYDRYL OXIDASE ALR nucleotide binding#GO:0000166;protein-disulfide reductase activity#GO:0015035;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;flavin adenine dinucleotide binding#GO:0050660;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;disulfide oxidoreductase activity#GO:0015036;ion binding#GO:0043167;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxidase#PC00175;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG173990|UniProtKB=T1F7G4 T1F7G4 20204763 PTHR11927:SF9 GALACTOSIDE 2-L-FUCOSYLTRANSFERASE L-FUCOSYLTRANSFERASE transferase activity#GO:0016740;fucosyltransferase activity#GO:0008417;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein glycosylation#GO:0006486;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycosylation#GO:0070085;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG175667|UniProtKB=T1F9H8 T1F9H8 20205477 PTHR28495:SF1 HYPOTHETICAL PROTEIN LOC100359752 GENE, 17266-RELATED HELRO|EnsemblGenome=HelroG179686|UniProtKB=T1FF11 T1FF11 20207410 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG172557|UniProtKB=T1F5I5 T1F5I5 20204084 PTHR12877:SF15 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 17 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022 HELRO|EnsemblGenome=HelroG165062|UniProtKB=T1EW84 T1EW84 20200834 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161910|UniProtKB=T1ES14 T1ES14 20199364 PTHR11051:SF8 GLYCOSYL HYDROLASE-RELATED PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 carbohydrate metabolic process#GO:0005975;organic substance metabolic process#GO:0071704;primary metabolic process#GO:0044238;metabolic process#GO:0008152 glycosidase#PC00110;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG184048|UniProtKB=T1FKH4 T1FKH4 20209323 PTHR37404:SF1 HCG1796489 HCG1796489 HELRO|EnsemblGenome=HelroG177629|UniProtKB=T1FBY7 T1FBY7 20206336 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157129|UniProtKB=T1EM68 T1EM68 20197668 PTHR23339:SF98 TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE PRL-1 PHOSPHATASE protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG176388|UniProtKB=T1FAG9 T1FAG9 20205818 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG159024|UniProtKB=T1ENH7 T1ENH7 20198127 PTHR11324:SF16 IL16-RELATED PDZ DOMAIN-CONTAINING PROTEIN 2 cytokine#PC00083;interleukin superfamily#PC00128 HELRO|EnsemblGenome=HelroG182698|UniProtKB=T1FIL4 T1FIL4 20208663 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG174907|UniProtKB=T1F8L7 T1F8L7 20205166 PTHR12692:SF0 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED GH11935P glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein N-linked glycosylation#GO:0006487;protein metabolic process#GO:0019538;protein N-linked glycosylation via asparagine#GO:0018279;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 membrane protein complex#GO:0098796;endoplasmic reticulum protein-containing complex#GO:0140534;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endoplasmic reticulum subcompartment#GO:0098827;oligosaccharyltransferase complex#GO:0008250;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG190832|UniProtKB=T1FSC2 T1FSC2 20211719 PTHR12988:SF6 SPHINGOMYELIN PHOSPHODIESTERASE 4 SPHINGOMYELIN PHOSPHODIESTERASE 4 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;phosphoric diester hydrolase activity#GO:0008081;phospholipase activity#GO:0004620;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 lipid metabolic process#GO:0006629;organonitrogen compound catabolic process#GO:1901565;lipid catabolic process#GO:0016042;glycerophospholipid catabolic process#GO:0046475;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;sphingolipid metabolic process#GO:0006665;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;sphingolipid catabolic process#GO:0030149;cellular lipid catabolic process#GO:0044242;amide metabolic process#GO:0043603;sphingolipid biosynthetic process#GO:0030148;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;glycerophospholipid metabolic process#GO:0006650;cellular biosynthetic process#GO:0044249;glycerolipid catabolic process#GO:0046503;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;membrane lipid biosynthetic process#GO:0046467;ceramide metabolic process#GO:0006672;organophosphate catabolic process#GO:0046434;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;membrane lipid metabolic process#GO:0006643;ceramide biosynthetic process#GO:0046513;phospholipid catabolic process#GO:0009395;organophosphate metabolic process#GO:0019637;cellular lipid metabolic process#GO:0044255 phosphodiesterase#PC00185;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG166769|UniProtKB=T1EYI1 T1EYI1 20201631 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179263|UniProtKB=T1FEG3 T1FEG3 20207212 PTHR24260:SF132 FAMILY NOT NAMED PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG85683|UniProtKB=T1G616 T1G616 20216513 PTHR10117:SF54 TRANSIENT RECEPTOR POTENTIAL CHANNEL TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;small molecule binding#GO:0036094;binding#GO:0005488;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;anion binding#GO:0043168;ion binding#GO:0043167;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;alcohol binding#GO:0043178 inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;regulation of cytosolic calcium ion concentration#GO:0051480;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;calcium ion transport#GO:0006816;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 Alzheimer disease-presenilin pathway#P00004>Capacitative calcium channels#P00124 HELRO|EnsemblGenome=HelroG175668|UniProtKB=T1F9H9 T1F9H9 20205478 PTHR24418:SF294 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE BTK29A protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 non-receptor tyrosine protein kinase#PC00168 HELRO|EnsemblGenome=HelroG102185|UniProtKB=T1ED87 T1ED87 20194539 PTHR12856:SF0 TRANSCRIPTION INITIATION FACTOR IIH-RELATED GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 1 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;RNA metabolic process#GO:0016070;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;transcription by RNA polymerase I#GO:0006360;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;cellular response to stress#GO:0033554;transcription by RNA polymerase II#GO:0006366;DNA metabolic process#GO:0006259 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;DNA-directed RNA polymerase complex#GO:0000428;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;nucleoplasm#GO:0005654;transferase complex#GO:1990234;intracellular organelle lumen#GO:0070013;serine/threonine protein kinase complex#GO:1902554;RNA polymerase II transcription regulator complex#GO:0090575;protein kinase complex#GO:1902911;transcription factor TFIIH core complex#GO:0000439;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;transcription regulator complex#GO:0005667;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;transcription factor TFIIH holo complex#GO:0005675;nuclear protein-containing complex#GO:0140513 general transcription factor#PC00259 Transcription regulation by bZIP transcription factor#P00055>TFIIH complex#P01392;General transcription regulation#P00023>TFIIH complex#P00664 HELRO|EnsemblGenome=HelroG114062|UniProtKB=T1EFY6 T1EFY6 20195488 PTHR11920:SF494 GUANYLYL CYCLASE ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2 adenylate cyclase activity#GO:0004016;signaling receptor activity#GO:0038023;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;lyase activity#GO:0016829;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653 cellular aromatic compound metabolic process#GO:0006725;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cyclic nucleotide metabolic process#GO:0009187;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;signaling#GO:0023052;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cell communication#GO:0007154;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organic cyclic compound biosynthetic process#GO:1901362;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide metabolic process#GO:0009150;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;carbohydrate derivative biosynthetic process#GO:1901137;response to stimulus#GO:0050896;ribonucleotide biosynthetic process#GO:0009260;enzyme-linked receptor protein signaling pathway#GO:0007167;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cGMP biosynthetic process#GO:0006182;biological regulation#GO:0065007;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleotide biosynthetic process#GO:0009152;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 guanylate cyclase#PC00114 Gonadotropin-releasing hormone receptor pathway#P06664>Npr2#P06796;Endothelin signaling pathway#P00019>Guanylate cyclase#P00581 HELRO|EnsemblGenome=HelroG183181|UniProtKB=T1FJ96 T1FJ96 20208895 PTHR12298:SF4 PCDC2 PROGRAMMED CELL DEATH PROTEIN 2 -RELATED PROGRAMMED CELL DEATH PROTEIN 2 HELRO|EnsemblGenome=HelroG86325|UniProtKB=T1G6A5 T1G6A5 20216602 PTHR18966:SF422 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED signaling receptor activity#GO:0038023;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;ligand-gated channel activity#GO:0022834 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019 HELRO|EnsemblGenome=HelroG166057|UniProtKB=T1EXN4 T1EXN4 20201334 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG100431|UniProtKB=T1ECZ7 T1ECZ7 20194449 PTHR15588:SF9 LSM1 U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;mRNA splicing, via spliceosome#GO:0000398;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 U6 snRNP#GO:0005688;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;U4/U6 x U5 tri-snRNP complex#GO:0046540;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;spliceosomal tri-snRNP complex#GO:0097526;membrane-bounded organelle#GO:0043227;precatalytic spliceosome#GO:0071011;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG174587|UniProtKB=T1F8A0 T1F8A0 20205049 PTHR14369:SF0 SURFEIT LOCUS PROTEIN 6 SURFEIT LOCUS PROTEIN 6 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;ribosome biogenesis#GO:0042254;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;ribosomal small subunit biogenesis#GO:0042274;ribonucleoprotein complex biogenesis#GO:0022613 membrane-enclosed lumen#GO:0031974;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG193546|UniProtKB=T1FV40 T1FV40 20212686 PTHR46402:SF2 SET AND MYND DOMAIN-CONTAINING PROTEIN 5 HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5 N-methyltransferase activity#GO:0008170;histone modifying activity#GO:0140993;transferase activity#GO:0016740;catalytic activity#GO:0003824;histone methyltransferase activity#GO:0042054;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;protein-lysine N-methyltransferase activity#GO:0016279;catalytic activity, acting on a protein#GO:0140096;lysine N-methyltransferase activity#GO:0016278;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein methyltransferase activity#GO:0008276 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;protein-DNA complex organization#GO:0071824;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;negative regulation of gene expression, epigenetic#GO:0045814;cellular process#GO:0009987;epigenetic regulation of gene expression#GO:0040029;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;protein-containing complex organization#GO:0043933;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;chromatin remodeling#GO:0006338;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 HELRO|EnsemblGenome=HelroG178681|UniProtKB=T1FDK3 T1FDK3 20206902 PTHR47958:SF104 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE WM6 catalytic activity, acting on RNA#GO:0140098;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640;mRNA binding#GO:0003729 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG64113|UniProtKB=T1FXP6 T1FXP6 20213594 PTHR11055:SF1 BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE PAPS SYNTHETASE, ISOFORM D transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 Sulfate assimilation#P02778>Sulfate adenylyltransferase#P03167;Sulfate assimilation#P02778>Adenylylsulfate kinase#P03164 HELRO|EnsemblGenome=HelroG190218|UniProtKB=T1FRS2 T1FRS2 20211519 PTHR45737:SF5 VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A POLY [ADP-RIBOSE] POLYMERASE-RELATED HELRO|EnsemblGenome=HelroG172299|UniProtKB=T1F569 T1F569 20203968 PTHR44942:SF4 METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG194361|UniProtKB=T1FVZ5 T1FVZ5 20212991 PTHR31802:SF45 32 KDA HEAT SHOCK PROTEIN-RELATED AGAP002961-PA HELRO|EnsemblGenome=HelroG191270|UniProtKB=T1FST6 T1FST6 20211883 PTHR12549:SF38 JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN JMJC DOMAIN-CONTAINING HISTONE DEMETHYLASE 2, ISOFORM A histone modifying activity#GO:0140993;nucleic acid binding#GO:0003676;histone demethylase activity#GO:0032452;binding#GO:0005488;catalytic activity#GO:0003824;protein-macromolecule adaptor activity#GO:0030674;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;demethylase activity#GO:0032451;molecular adaptor activity#GO:0060090;chromatin DNA binding#GO:0031490;chromatin binding#GO:0003682;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;protein-containing complex binding#GO:0044877;catalytic activity, acting on a protein#GO:0140096 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;nucleoplasm#GO:0005654;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;histone deacetylase complex#GO:0000118;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HELRO|EnsemblGenome=HelroG182100|UniProtKB=T1FHR1 T1FHR1 20208360 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG158731|UniProtKB=T1EN60 T1EN60 20198010 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG74633|UniProtKB=T1G1T4 T1G1T4 20215032 PTHR24637:SF388 COLLAGEN NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG180923|UniProtKB=T1FGF3 T1FGF3 20207902 PTHR13174:SF3 D-GLUCURONYL C5-EPIMERASE D-GLUCURONYL C5-EPIMERASE racemase and epimerase activity, acting on carbohydrates and derivatives#GO:0016857;isomerase activity#GO:0016853;catalytic activity#GO:0003824 glycoprotein biosynthetic process#GO:0009101;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;sulfur compound metabolic process#GO:0006790;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;proteoglycan metabolic process#GO:0006029;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;proteoglycan biosynthetic process#GO:0030166;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 isomerase#PC00135;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG124292|UniProtKB=T1EH08 T1EH08 20195858 PTHR12121:SF34 CARBON CATABOLITE REPRESSOR PROTEIN 4 PROTEIN ANGEL catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787;3'-5'-RNA exonuclease activity#GO:0000175;exonuclease activity#GO:0004527;3'-5' exonuclease activity#GO:0008408;RNA nuclease activity#GO:0004540 mRNA polyadenylation factor#PC00146 HELRO|EnsemblGenome=HelroG66965|UniProtKB=T1FYU0 T1FYU0 20213988 PTHR15852:SF54 PLASTID TRANSCRIPTIONALLY ACTIVE PROTEIN PROTEIN SSUH2 HOMOLOG HELRO|EnsemblGenome=HelroG83212|UniProtKB=T1G521 T1G521 20216169 PTHR46289:SF17 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG107038|UniProtKB=T1EE68 T1EE68 20194870 PTHR11705:SF91 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B FI01817P-RELATED metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metallocarboxypeptidase activity#GO:0004181;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;carboxypeptidase activity#GO:0004180 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 metalloprotease#PC00153;protease#PC00190 HELRO|EnsemblGenome=HelroG96551|UniProtKB=T1G9C8 T1G9C8 20217675 PTHR12558:SF10 CELL DIVISION CYCLE 16,23,27 CELL DIVISION CYCLE PROTEIN 23 HOMOLOG cell division#GO:0051301;regulation of mitotic nuclear division#GO:0007088;regulation of chromosome segregation#GO:0051983;positive regulation of organelle organization#GO:0010638;macromolecule modification#GO:0043412;regulation of chromosome separation#GO:1905818;protein catabolic process#GO:0030163;organonitrogen compound catabolic process#GO:1901565;protein modification process#GO:0036211;regulation of cellular component organization#GO:0051128;positive regulation of cell cycle#GO:0045787;post-translational protein modification#GO:0043687;modification-dependent macromolecule catabolic process#GO:0043632;regulation of biological process#GO:0050789;nitrogen compound metabolic process#GO:0006807;positive regulation of cell cycle process#GO:0090068;positive regulation of mitotic cell cycle#GO:0045931;proteolysis#GO:0006508;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;positive regulation of biological process#GO:0048518;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;regulation of chromosome organization#GO:0033044;macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;regulation of mitotic sister chromatid separation#GO:0010965;regulation of nuclear division#GO:0051783;protein modification by small protein conjugation or removal#GO:0070647;regulation of mitotic cell cycle phase transition#GO:1901990;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of organelle organization#GO:0033043;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;positive regulation of mitotic nuclear division#GO:0045840;regulation of cell cycle phase transition#GO:1901987;organonitrogen compound metabolic process#GO:1901564;cellular process#GO:0009987;regulation of mitotic metaphase/anaphase transition#GO:0030071;primary metabolic process#GO:0044238;regulation of cell cycle process#GO:0010564;positive regulation of cellular process#GO:0048522;ubiquitin-dependent protein catabolic process#GO:0006511;anaphase-promoting complex-dependent catabolic process#GO:0031145;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;regulation of cell cycle#GO:0051726;regulation of sister chromatid segregation#GO:0033045;regulation of mitotic cell cycle#GO:0007346 ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234;anaphase-promoting complex#GO:0005680;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG193092|UniProtKB=T1FUM3 T1FUM3 20212519 PTHR15077:SF12 FAS-ASSOCIATING DEATH DOMAIN-CONTAINING PROTEIN FADD DEATH DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG174505|UniProtKB=T1F871 T1F871 20205020 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG183103|UniProtKB=T1FJ54 T1FJ54 20208853 PTHR10024:SF374 SYNAPTOTAGMIN C2 DOMAIN-CONTAINING PROTEIN cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;phosphatidylserine binding#GO:0001786;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;protein binding#GO:0005515;clathrin binding#GO:0030276;lipid binding#GO:0008289;ion binding#GO:0043167;phospholipid binding#GO:0005543;SNARE binding#GO:0000149 localization#GO:0051179;regulated exocytosis#GO:0045055;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;calcium-ion regulated exocytosis#GO:0017156;export from cell#GO:0140352;secretion by cell#GO:0032940 intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;secretory vesicle#GO:0099503;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG185649|UniProtKB=T1FN33 T1FN33 20210232 PTHR13299:SF0 PEROXISOMAL MEMBRANE PROTEIN PEX16 PEROXISOMAL MEMBRANE PROTEIN PEX16 cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cellular process#GO:0009987;organelle organization#GO:0006996;peroxisome organization#GO:0007031 peroxisomal membrane#GO:0005778;cytoplasm#GO:0005737;bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;microbody#GO:0042579;peroxisome#GO:0005777;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG193655|UniProtKB=T1FV84 T1FV84 20212730 PTHR31002:SF34 SERIPAUPERIN CELL WALL PROTEIN CWP1-RELATED HELRO|EnsemblGenome=HelroG166856|UniProtKB=T1EYN0 T1EYN0 20201680 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG113546|UniProtKB=T1EFT3 T1EFT3 20195435 PTHR15949:SF3 TESTIS-EXPRESSED PROTEIN 264 TESTIS-EXPRESSED PROTEIN 264 HELRO|EnsemblGenome=HelroG159073|UniProtKB=T1ENJ9 T1ENJ9 20198149 PTHR23043:SF17 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA PROTEIN SIMILAR basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG188709|UniProtKB=T1FQA3 T1FQA3 20211000 PTHR11827:SF73 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS KAZACHOC, ISOFORM G inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium ion transmembrane transporter activity#GO:0015079;symporter activity#GO:0015293;chloride transmembrane transporter activity#GO:0015108;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 inorganic ion homeostasis#GO:0098771;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;chloride transmembrane transport#GO:1902476;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;inorganic anion transmembrane transport#GO:0098661;import across plasma membrane#GO:0098739;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;inorganic anion transport#GO:0015698;potassium ion transport#GO:0006813;regulation of anatomical structure size#GO:0090066;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;monoatomic anion transmembrane transport#GO:0098656;chloride transport#GO:0006821;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;cellular component organization#GO:0016043;cellular process#GO:0009987;chemical homeostasis#GO:0048878;regulation of cellular component size#GO:0032535;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;regulation of cell size#GO:0008361;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;potassium ion import across plasma membrane#GO:1990573 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG92165|UniProtKB=T1G8C6 T1G8C6 20217323 PTHR24208:SF127 LIM/HOMEOBOX PROTEIN LHX LIM_HOMEOBOX PROTEIN AWH sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;neurogenesis#GO:0022008;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;system development#GO:0048731;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;regulation of macromolecule biosynthetic process#GO:0010556;generation of neurons#GO:0048699;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG177433|UniProtKB=T1FBP4 T1FBP4 20206243 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179908|UniProtKB=T1FF88 T1FF88 20207487 PTHR31802:SF49 32 KDA HEAT SHOCK PROTEIN-RELATED TRANSMEMBRANE PROTEIN HELRO|EnsemblGenome=HelroG161792|UniProtKB=T1ERX3 T1ERX3 20199323 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG190172|UniProtKB=T1FRR4 T1FRR4 20211511 PTHR22590:SF5 MYOSIN MOTOR DOMAIN-CONTAINING PROTEIN MYOSIN MOTOR DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG168397|UniProtKB=T1F0J6 T1F0J6 20202346 PTHR46114:SF1 APPLE DOMAIN-CONTAINING PROTEIN ZAD DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG85228|UniProtKB=T1G5U5 T1G5U5 20216442 PTHR12027:SF102 WNT RELATED PROTEIN WNT molecular function activator activity#GO:0140677;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;protein binding#GO:0005515;cytokine activity#GO:0005125;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102 cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;neurogenesis#GO:0022008;developmental process#GO:0032502;multicellular organism development#GO:0007275;cell communication#GO:0007154;cell fate commitment#GO:0045165;cell-cell signaling by wnt#GO:0198738;nervous system development#GO:0007399;cellular process#GO:0009987;regulation of biological process#GO:0050789;system development#GO:0048731;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;cell-cell signaling#GO:0007267;signaling#GO:0023052;canonical Wnt signaling pathway#GO:0060070;Wnt signaling pathway#GO:0016055 cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Cadherin signaling pathway#P00012>Wnt#P00474 HELRO|EnsemblGenome=HelroG82753|UniProtKB=T1G4W2 T1G4W2 20216110 PTHR48112:SF22 HIGH MOBILITY GROUP PROTEIN DSP1 MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG190503|UniProtKB=T1FS18 T1FS18 20211615 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG190906|UniProtKB=T1FSE7 T1FSE7 20211744 PTHR10670:SF0 DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A hydrolase activity, acting on ester bonds#GO:0016788;nucleic acid binding#GO:0003676;DNA-directed DNA polymerase activity#GO:0003887;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;3'-5'-DNA exonuclease activity#GO:0008296;nuclease activity#GO:0004518;DNA exonuclease activity#GO:0004529;binding#GO:0005488;catalytic activity#GO:0003824;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters#GO:0016796;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;exonuclease activity#GO:0004527;transferase activity#GO:0016740;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;hydrolase activity#GO:0016787;catalytic activity, acting on DNA#GO:0140097;DNA nuclease activity#GO:0004536;3'-5' exonuclease activity#GO:0008408;DNA polymerase activity#GO:0034061 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;nucleotide-excision repair#GO:0006289;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;base-excision repair#GO:0006284;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;DNA damage response#GO:0006974;mitotic cell cycle#GO:0000278;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;DNA-templated DNA replication#GO:0006261;cell cycle#GO:0007049;cellular response to stress#GO:0033554;DNA replication#GO:0006260;metabolic process#GO:0008152;DNA strand elongation involved in DNA replication#GO:0006271;DNA metabolic process#GO:0006259;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;epsilon DNA polymerase complex#GO:0008622;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear chromosome#GO:0000228;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;DNA polymerase complex#GO:0042575;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG122015|UniProtKB=T1EGT6 T1EGT6 20195786 PTHR12223:SF28 VESICULAR MANNOSE-BINDING LECTIN LECTIN, MANNOSE BINDING 1 LIKE carbohydrate binding#GO:0030246;small molecule binding#GO:0036094;binding#GO:0005488;monosaccharide binding#GO:0048029 localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987 bounding membrane of organelle#GO:0098588;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;coated vesicle#GO:0030135;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;Golgi membrane#GO:0000139;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG188234|UniProtKB=T1FPS9 T1FPS9 20210826 PTHR15960:SF5 LD44032P LD44032P protein binding#GO:0005515;ubiquitin-like protein binding#GO:0032182;binding#GO:0005488;ubiquitin binding#GO:0043130 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endosome membrane#GO:0010008;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ESCRT I complex#GO:0000813;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle membrane#GO:0030659 HELRO|EnsemblGenome=HelroG109253|UniProtKB=T1EER9 T1EER9 20195071 PTHR10972:SF205 OXYSTEROL-BINDING PROTEIN-RELATED OXYSTEROL-BINDING PROTEIN 1 binding#GO:0005488;organic cyclic compound binding#GO:0097159;steroid binding#GO:0005496;sterol transporter activity#GO:0015248;sterol binding#GO:0032934;lipid binding#GO:0008289;lipid transporter activity#GO:0005319;transporter activity#GO:0005215 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG125362|UniProtKB=T1EH55 T1EH55 20195905 PTHR24155:SF11 OSTEOCLAST-STIMULATING FACTOR 1 CASKIN, ISOFORM B phosphatase binding#GO:0019902;molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;protein binding#GO:0005515;enzyme binding#GO:0019899;protein phosphatase binding#GO:0019903 signal transduction#GO:0007165;neurogenesis#GO:0022008;cell projection organization#GO:0030030;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular anatomical entity morphogenesis#GO:0032989;regulation of biological process#GO:0050789;system development#GO:0048731;cell differentiation#GO:0030154;anatomical structure morphogenesis#GO:0009653;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;axonogenesis#GO:0007409;signaling#GO:0023052;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;multicellular organism development#GO:0007275;cellular component organization#GO:0016043;cell communication#GO:0007154;cell morphogenesis#GO:0000902;cellular process#GO:0009987;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;response to stimulus#GO:0050896;neuron projection development#GO:0031175;enzyme-linked receptor protein signaling pathway#GO:0007167;axon development#GO:0061564;cell morphogenesis involved in neuron differentiation#GO:0048667;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 anchoring junction#GO:0070161;neuron projection#GO:0043005;focal adhesion#GO:0005925;cell junction#GO:0030054;cell-substrate junction#GO:0030055;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;axon#GO:0030424 HELRO|EnsemblGenome=HelroG163822|UniProtKB=T1EUI4 T1EUI4 20200234 PTHR11567:SF110 ACID PHOSPHATASE-RELATED 2-PHOSPHOXYLOSE PHOSPHATASE 1 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 cellular metabolic process#GO:0044237;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;dephosphorylation#GO:0016311;metabolic process#GO:0008152 metabolite interconversion enzyme#PC00262;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG166864|UniProtKB=T1EYN5 T1EYN5 20201685 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG183421|UniProtKB=T1FJM2 T1FJM2 20209021 PTHR46641:SF25 FMRFAMIDE RECEPTOR-RELATED CNMAMIDE RECEPTOR-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG185301|UniProtKB=T1FMM9 T1FMM9 20210078 PTHR11458:SF0 DELTA-AMINOLEVULINIC ACID DEHYDRATASE DELTA-AMINOLEVULINIC ACID DEHYDRATASE cation binding#GO:0043169;carbon-oxygen lyase activity#GO:0016835;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;hydro-lyase activity#GO:0016836;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;lyase activity#GO:0016829;ion binding#GO:0043167 tetrapyrrole metabolic process#GO:0033013;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;pigment metabolic process#GO:0042440;porphyrin-containing compound metabolic process#GO:0006778;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;heme biosynthetic process#GO:0006783;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;pigment biosynthetic process#GO:0046148;aromatic compound biosynthetic process#GO:0019438;organic substance metabolic process#GO:0071704;heme metabolic process#GO:0042168;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 dehydratase#PC00091;lyase#PC00144 Heme biosynthesis#P02746>porphobilinogen synthase#P02979 HELRO|EnsemblGenome=HelroG107172|UniProtKB=T1EE84 T1EE84 20194886 PTHR12944:SF2 SOLUBLE LIVER ANTIGEN/LIVER PANCREAS ANTIGEN O-PHOSPHOSERYL-TRNA(SEC) SELENIUM TRANSFERASE tRNA binding#GO:0000049;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of protein metabolic process#GO:0051246;regulation of amide metabolic process#GO:0034248;regulation of nitrogen compound metabolic process#GO:0051171;peptide metabolic process#GO:0006518;gene expression#GO:0010467;biosynthetic process#GO:0009058;translation#GO:0006412;regulation of biological process#GO:0050789;nitrogen compound metabolic process#GO:0006807;regulation of biosynthetic process#GO:0009889;cellular nitrogen compound biosynthetic process#GO:0044271;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;regulation of primary metabolic process#GO:0080090;peptide biosynthetic process#GO:0043043;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of translation#GO:0006417;translational elongation#GO:0006414;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 HELRO|EnsemblGenome=HelroG156985|UniProtKB=T1EM44 T1EM44 20197644 PTHR43389:SF4 V-TYPE PROTON ATPASE SUBUNIT B V-TYPE PROTON ATPASE SUBUNIT B ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG187100|UniProtKB=T1FP70 T1FP70 20210617 PTHR24353:SF111 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE SUBFAMILY NOT NAMED non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Endothelin signaling pathway#P00019>PKG#P00567 HELRO|EnsemblGenome=HelroG71174|UniProtKB=T1G0H4 T1G0H4 20214572 PTHR11616:SF321 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;organic acid:sodium symporter activity#GO:0005343;organic acid transmembrane transporter activity#GO:0005342;symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;organic anion transmembrane transporter activity#GO:0008514;monoatomic cation transmembrane transporter activity#GO:0008324;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;amino acid:sodium symporter activity#GO:0005283;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;metal ion transmembrane transporter activity#GO:0046873;active monoatomic ion transmembrane transporter activity#GO:0022853;amino acid transmembrane transporter activity#GO:0015171;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;organic anion transport#GO:0015711;amino acid transport#GO:0006865;organic acid transport#GO:0015849;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;nitrogen compound transport#GO:0071705;carboxylic acid transport#GO:0046942;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;amino acid import across plasma membrane#GO:0089718;carboxylic acid transmembrane transport#GO:1905039;localization#GO:0051179;organic substance transport#GO:0071702;import across plasma membrane#GO:0098739;amino acid transmembrane transport#GO:0003333;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transport#GO:0006812;organic acid transmembrane transport#GO:1903825;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;import into cell#GO:0098657;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>CHT1#P01084 HELRO|EnsemblGenome=HelroG91526|UniProtKB=T1G849 T1G849 20217246 PTHR31655:SF7 PROTEIN FAM78A PROTEIN FAM78A HELRO|EnsemblGenome=HelroG147404|UniProtKB=T1EK00 T1EK00 20196900 PTHR19965:SF82 RNA AND EXPORT FACTOR BINDING PROTEIN THO COMPLEX SUBUNIT 4 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;macromolecule metabolic process#GO:0043170;transport#GO:0006810;nucleic acid transport#GO:0050657;nitrogen compound transport#GO:0071705;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;mRNA transport#GO:0051028;RNA localization#GO:0006403;localization#GO:0051179;organic substance transport#GO:0071702;nuclear export#GO:0051168;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;nuclear transport#GO:0051169;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG158150|UniProtKB=T1EMJ8 T1EMJ8 20197798 PTHR11785:SF528 AMINO ACID TRANSPORTER AMINO ACID TRANSPORTER PROTEIN JHI-21 L-amino acid transmembrane transporter activity#GO:0015179;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;amino acid transport#GO:0006865;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;nitrogen compound transport#GO:0071705;organic acid transmembrane transport#GO:1903825;carboxylic acid transport#GO:0046942;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039 transporter#PC00227 HELRO|EnsemblGenome=HelroG183536|UniProtKB=T1FJT3 T1FJT3 20209082 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182120|UniProtKB=T1FHS4 T1FHS4 20208373 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG95367|UniProtKB=T1G954 T1G954 20217601 PTHR11675:SF133 N-ACETYLGALACTOSAMINYLTRANSFERASE GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG193538|UniProtKB=T1FV37 T1FV37 20212683 PTHR23512:SF5 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1 HELRO|EnsemblGenome=HelroG158421|UniProtKB=T1EMR8 T1EMR8 20197868 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG68834|UniProtKB=T1FZK3 T1FZK3 20214251 PTHR11347:SF226 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE DUAL SPECIFICITY CALCIUM_CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric diester hydrolase activity#GO:0008081;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;cAMP-mediated signaling#GO:0019933;signaling#GO:0023052;cyclic-nucleotide-mediated signaling#GO:0019935 phosphodiesterase#PC00185 HELRO|EnsemblGenome=HelroG100627|UniProtKB=T1ED08 T1ED08 20194460 PTHR12785:SF6 SPLICING FACTOR 3B SPLICING FACTOR 3B SUBUNIT 2 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG70335|UniProtKB=T1G050 T1G050 20214448 PTHR19960:SF11 TEKTIN TEKTIN cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cilium or flagellum-dependent cell motility#GO:0001539;cell motility#GO:0048870;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;cilium movement involved in cell motility#GO:0060294;cilium movement#GO:0003341;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cilium-dependent cell motility#GO:0060285;microtubule-based process#GO:0007017;organelle organization#GO:0006996;plasma membrane bounded cell projection assembly#GO:0120031 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG193553|UniProtKB=T1FV45 T1FV45 20212691 PTHR24083:SF46 NUCLEAR HORMONE RECEPTOR STEROID RECEPTOR SEVEN-UP, ISOFORM A cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;signaling receptor activity#GO:0038023;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG167615|UniProtKB=T1EZK4 T1EZK4 20202004 PTHR24238:SF75 G-PROTEIN COUPLED RECEPTOR CHOLECYSTOKININ-LIKE RECEPTOR AT 17D1-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;neuropeptide signaling pathway#GO:0007218;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG74316|UniProtKB=T1G1P7 T1G1P7 20214995 PTHR11452:SF14 ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE ALPHA-GALACTOSIDASE A hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 carbohydrate derivative metabolic process#GO:1901135;glycosyl compound catabolic process#GO:1901658;carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;glycosyl compound metabolic process#GO:1901657;carbohydrate metabolic process#GO:0005975;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 galactosidase#PC00104;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG94284|UniProtKB=T1G8Z9 T1G8Z9 20217546 PTHR12940:SF0 ES-2 PROTEIN - RELATED SPLICING FACTOR ESS-2 HOMOLOG ribonucleoprotein complex#GO:1990904;catalytic step 2 spliceosome#GO:0071013;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG75878|UniProtKB=T1G2C0 T1G2C0 20215218 PTHR11075:SF54 PEPTIDE CHAIN RELEASE FACTOR LARGE RIBOSOMAL SUBUNIT PROTEIN ML62 catalytic activity, acting on RNA#GO:0140098;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;translation regulator activity#GO:0045182;nucleic acid binding#GO:0003676;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787;translation regulator activity, nucleic acid binding#GO:0090079;translation factor activity, RNA binding#GO:0008135 translation release factor#PC00225;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG176307|UniProtKB=T1FAD7 T1FAD7 20205786 PTHR14445:SF46 GRB10 INTERACTING GYF PROTEIN SUBFAMILY NOT NAMED cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG156036|UniProtKB=T1ELQ9 T1ELQ9 20197509 PTHR48015:SF21 SERINE/THREONINE-PROTEIN KINASE TAO MISSHAPEN, ISOFORM A transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 regulation of MAPK cascade#GO:0043408;signal transduction#GO:0007165;neurogenesis#GO:0022008;cell projection organization#GO:0030030;macromolecule modification#GO:0043412;developmental process#GO:0032502;regulation of signaling#GO:0023051;protein modification process#GO:0036211;MAPK cascade#GO:0000165;cell projection morphogenesis#GO:0048858;nervous system development#GO:0007399;regulation of intracellular signal transduction#GO:1902531;plasma membrane bounded cell projection organization#GO:0120036;phosphorus metabolic process#GO:0006793;cellular anatomical entity morphogenesis#GO:0032989;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;system development#GO:0048731;cell differentiation#GO:0030154;anatomical structure morphogenesis#GO:0009653;nitrogen compound metabolic process#GO:0006807;regulation of signal transduction#GO:0009966;neuron differentiation#GO:0030182;phosphorylation#GO:0016310;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;plasma membrane bounded cell projection morphogenesis#GO:0120039;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular developmental process#GO:0048869;regulation of cell communication#GO:0010646;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;multicellular organism development#GO:0007275;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;cell communication#GO:0007154;cell morphogenesis#GO:0000902;cellular component organization#GO:0016043;cellular process#GO:0009987;primary metabolic process#GO:0044238;cell development#GO:0048468;regulation of response to stimulus#GO:0048583;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;biological regulation#GO:0065007;neuron development#GO:0048666;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG171666|UniProtKB=T1F4J0 T1F4J0 20203739 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG182101|UniProtKB=T1FHR2 T1FHR2 20208361 PTHR21490:SF2 ENKURIN-RELATED ENKURIN DOMAIN-CONTAINING PROTEIN 1 supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cytoplasmic microtubule#GO:0005881;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG66489|UniProtKB=T1FYM1 T1FYM1 20213919 PTHR12879:SF8 SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2 SPHINGOLIPID DELTA(4)-DESATURASE DES1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 lipid metabolic process#GO:0006629;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;membrane lipid biosynthetic process#GO:0046467;sphingolipid metabolic process#GO:0006665;ceramide metabolic process#GO:0006672;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;membrane lipid metabolic process#GO:0006643;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;ceramide biosynthetic process#GO:0046513;cellular lipid metabolic process#GO:0044255;amide metabolic process#GO:0043603;sphingolipid biosynthetic process#GO:0030148;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 hydroxylase#PC00122 HELRO|EnsemblGenome=HelroG63872|UniProtKB=T1FXL4 T1FXL4 20213562 PTHR11849:SF190 ETS ETS-DOMAIN PROTEIN transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG143678|UniProtKB=T1EJB7 T1EJB7 20196667 PTHR22957:SF497 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN ECOTROPIC VIRAL INTEGRATION SITE 5 ORTHOLOG nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of molecular function#GO:0065009;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;activation of GTPase activity#GO:0090630;biological regulation#GO:0065007;positive regulation of molecular function#GO:0044093;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;positive regulation of hydrolase activity#GO:0051345 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG181329|UniProtKB=T1FGW4 T1FGW4 20208063 PTHR19960:SF25 TEKTIN TEKTIN-1 cellular component assembly#GO:0022607;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cilium or flagellum-dependent cell motility#GO:0001539;cell motility#GO:0048870;cellular component organization#GO:0016043;cellular process#GO:0009987;plasma membrane bounded cell projection organization#GO:0120036;cell projection assembly#GO:0030031;cilium movement involved in cell motility#GO:0060294;cilium movement#GO:0003341;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cilium-dependent cell motility#GO:0060285;microtubule-based process#GO:0007017;organelle organization#GO:0006996;plasma membrane bounded cell projection assembly#GO:0120031 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG173224|UniProtKB=T1F6L1 T1F6L1 20204460 PTHR34203:SF15 METHYLTRANSFERASE, FKBM FAMILY PROTEIN SLL1173 PROTEIN methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG169012|UniProtKB=T1F193 T1F193 20202593 PTHR11465:SF9 CATALASE CATALASE antioxidant activity#GO:0016209;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;tetrapyrrole binding#GO:0046906;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;oxidoreductase activity#GO:0016491;heme binding#GO:0020037 response to stimulus#GO:0050896;response to stress#GO:0006950;response to chemical#GO:0042221;response to oxygen-containing compound#GO:1901700;catabolic process#GO:0009056;cellular metabolic process#GO:0044237;response to reactive oxygen species#GO:0000302;response to oxidative stress#GO:0006979;cellular process#GO:0009987;cellular catabolic process#GO:0044248;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 peroxidase#PC00180;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG158533|UniProtKB=T1EMX5 T1EMX5 20197925 PTHR45749:SF21 FAMILY NOT NAMED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193928|UniProtKB=T1FVH4 T1FVH4 20212820 PTHR14388:SF17 T CELL-SPECIFIC ADAPTER PROTEIN TSAD SH2 DOMAIN-CONTAINING PROTEIN cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG163980|UniProtKB=T1EUP9 T1EUP9 20200299 PTHR28584:SF1 FAMILY WITH SEQUENCE SIMILARITY 228 MEMBER A PROTEIN FAM228B HELRO|EnsemblGenome=HelroG155397|UniProtKB=T1ELI2 T1ELI2 20197432 PTHR10188:SF6 L-ASPARAGINASE N(4)-(BETA-N-ACETYLGLUCOSAMINYL)-L-ASPARAGINASE protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG91842|UniProtKB=T1G897 T1G897 20217294 PTHR11552:SF147 GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE CHOLINE DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG193378|UniProtKB=T1FUX7 T1FUX7 20212623 PTHR15398:SF4 BROMODOMAIN-CONTAINING PROTEIN 8 BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1 HELRO|EnsemblGenome=HelroG170116|UniProtKB=T1F2N5 T1F2N5 20203084 PTHR47160:SF5 PUTATIVE-RELATED MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG112773|UniProtKB=T1EFM1 T1EFM1 20195373 PTHR15892:SF2 MITOCHONDRIAL RIBOSOMAL PROTEIN L30 LARGE RIBOSOMAL SUBUNIT PROTEIN UL30M ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG62517|UniProtKB=T1FX18 T1FX18 20213366 PTHR11584:SF394 SERINE/THREONINE PROTEIN KINASE APOPTOTIC SIGNAL-REGULATING KINASE 1, ISOFORM C transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 FGF signaling pathway#P00021>MEKK1-5#P00634;EGF receptor signaling pathway#P00018>MEKK1-5#P00553 HELRO|EnsemblGenome=HelroG160109|UniProtKB=T1EPT2 T1EPT2 20198582 PTHR46880:SF5 RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG68814|UniProtKB=T1FZJ9 T1FZJ9 20214247 PTHR24388:SF100 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 423 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG83777|UniProtKB=T1G5A1 T1G5A1 20216248 PTHR35268:SF1 PROTEIN CCSMST1 UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 4 HELRO|EnsemblGenome=HelroG75092|UniProtKB=T1G203 T1G203 20215101 PTHR12141:SF1 ARFAPTIN-RELATED PRKCA-BINDING PROTEIN enzyme binding#GO:0019899;protein binding#GO:0005515;lipid binding#GO:0008289;protein kinase binding#GO:0019901;phospholipid binding#GO:0005543;binding#GO:0005488;kinase binding#GO:0019900 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;regulation of localization#GO:0032879;regulation of cellular component organization#GO:0051128;establishment of protein localization#GO:0045184;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;organic substance transport#GO:0071702;regulation of cytoskeleton organization#GO:0051493;regulation of transport#GO:0051049;establishment of localization#GO:0051234;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament-based process#GO:0032970;positive regulation of biological process#GO:0048518;localization within membrane#GO:0051668;regulation of endocytosis#GO:0030100;protein localization to membrane#GO:0072657;regulation of organelle organization#GO:0033043;regulation of actin filament organization#GO:0110053;positive regulation of transport#GO:0051050;cellular process#GO:0009987;protein localization#GO:0008104;positive regulation of cellular process#GO:0048522;regulation of supramolecular fiber organization#GO:1902903;localization#GO:0051179;cellular macromolecule localization#GO:0070727;positive regulation of endocytosis#GO:0045807;regulation of cellular process#GO:0050794;protein transport#GO:0015031;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;receptor clustering#GO:0043113;regulation of receptor-mediated endocytosis#GO:0048259 cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;trans-Golgi network membrane#GO:0032588;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;Golgi apparatus subcompartment#GO:0098791;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 vesicle coat protein#PC00235 Ionotropic glutamate receptor pathway#P00037>PICK#P01012 HELRO|EnsemblGenome=HelroG73759|UniProtKB=T1G1I1 T1G1I1 20214929 PTHR11850:SF108 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS HOMEOBOX PROTEIN EXTRADENTICLE cellular developmental process#GO:0048869;neurogenesis#GO:0022008;animal organ development#GO:0048513;multicellular organism development#GO:0007275;developmental process#GO:0032502;cellular process#GO:0009987;nervous system development#GO:0007399;cell development#GO:0048468;system development#GO:0048731;embryonic organ development#GO:0048568;cell differentiation#GO:0030154;embryo development#GO:0009790;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;neuron differentiation#GO:0030182;animal organ morphogenesis#GO:0009887;neuron development#GO:0048666;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG138707|UniProtKB=T1EIW9 T1EIW9 20196519 PTHR19290:SF164 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED BHLH DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;neurogenesis#GO:0022008;positive regulation of RNA biosynthetic process#GO:1902680;cell projection organization#GO:0030030;regulation of nitrogen compound metabolic process#GO:0051171;animal organ development#GO:0048513;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;regulation of biological process#GO:0050789;system development#GO:0048731;cell differentiation#GO:0030154;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;neuron differentiation#GO:0030182;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;multicellular organism development#GO:0007275;cellular component organization#GO:0016043;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;cell development#GO:0048468;cellular component organization or biogenesis#GO:0071840;neuron projection development#GO:0031175;axon development#GO:0061564;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;anatomical structure development#GO:0048856;biological regulation#GO:0065007;neuron development#GO:0048666;multicellular organismal process#GO:0032501;positive regulation of RNA metabolic process#GO:0051254;generation of neurons#GO:0048699;sensory organ development#GO:0007423;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG74746|UniProtKB=T1G1V2 T1G1V2 20215050 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG105012|UniProtKB=T1EDP8 T1EDP8 20194700 PTHR45689:SF5 I[[H]] CHANNEL, ISOFORM E I[[H]] CHANNEL, ISOFORM E monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;channel activity#GO:0015267;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;sodium ion transport#GO:0006814;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;regulation of cellular process#GO:0050794;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;regulation of membrane depolarization#GO:0003254;sodium ion transmembrane transport#GO:0035725;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG107587|UniProtKB=T1EEB6 T1EEB6 20194918 PTHR11082:SF31 TRNA-DIHYDROURIDINE SYNTHASE TRNA-DIHYDROURIDINE(20A_20B) SYNTHASE [NAD(P)+]-LIKE catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor#GO:0016628 RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG82368|UniProtKB=T1G4R3 T1G4R3 20216061 PTHR19964:SF92 MULTIPLE PDZ DOMAIN PROTEIN PATJ HOMOLOG scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG80861|UniProtKB=T1G464 T1G464 20215862 PTHR14187:SF39 ALPHA KINASE/ELONGATION FACTOR 2 KINASE HEAT SHOCK 70 KDA PROTEIN 12B HELRO|EnsemblGenome=HelroG71510|UniProtKB=T1G0M4 T1G0M4 20214622 PTHR10845:SF259 REGULATOR OF G PROTEIN SIGNALING RGS DOMAIN-CONTAINING PROTEIN-RELATED G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG166292|UniProtKB=T1EXZ6 T1EXZ6 20201446 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG179365|UniProtKB=T1FEL9 T1FEL9 20207268 PTHR15921:SF3 PRE-MRNA CLEAVAGE COMPLEX II PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11 nucleic acid binding#GO:0003676;basal RNA polymerase II transcription machinery binding#GO:0001099;RNA binding#GO:0003723;RNA polymerase binding#GO:0070063;binding#GO:0005488;organic cyclic compound binding#GO:0097159;RNA polymerase core enzyme binding#GO:0043175;RNA polymerase II complex binding#GO:0000993;enzyme binding#GO:0019899;protein binding#GO:0005515;mRNA binding#GO:0003729;basal transcription machinery binding#GO:0001098 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;mRNA cleavage factor complex#GO:0005849;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG164120|UniProtKB=T1EUY4 T1EUY4 20200384 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG102273|UniProtKB=T1ED91 T1ED91 20194543 PTHR12686:SF8 3'-5' EXORIBONUCLEASE CSL4-RELATED EXOSOME COMPLEX COMPONENT CSL4 RNA metabolism protein#PC00031;exoribonuclease#PC00099 HELRO|EnsemblGenome=HelroG167266|UniProtKB=T1EZ70 T1EZ70 20201870 PTHR12534:SF0 30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR SMALL RIBOSOMAL SUBUNIT PROTEIN US2M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;translation#GO:0006412;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG63612|UniProtKB=T1FXI2 T1FXI2 20213530 PTHR24072:SF73 RHO FAMILY GTPASE MITOCHONDRIAL RHO GTPASE GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;anion binding#GO:0043168;ion binding#GO:0043167 mitochondrion organization#GO:0007005 envelope#GO:0031975;bounding membrane of organelle#GO:0098588;mitochondrial membrane#GO:0031966;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;mitochondrion#GO:0005739;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867 small GTPase#PC00208 HELRO|EnsemblGenome=HelroG173912|UniProtKB=T1F7D2 T1F7D2 20204731 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG165184|UniProtKB=T1EWE4 T1EWE4 20200894 PTHR33091:SF29 PROTEIN, PUTATIVE, EXPRESSED-RELATED SUBTILISIN INHIBITOR 1 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG116148|UniProtKB=T1EGD3 T1EGD3 20195635 PTHR23182:SF1 BREAKPOINT CLUSTER REGION PROTEIN BCR RHO GTPASE ACTIVATING PROTEIN AT 1A, ISOFORM E G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG120046|UniProtKB=T1EGP4 T1EGP4 20195744 PTHR24241:SF193 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;binding#GO:0005488;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888;amide binding#GO:0033218 response to organic substance#GO:0010033;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;cellular response to organic substance#GO:0071310;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to endogenous stimulus#GO:0009719;cellular response to hormone stimulus#GO:0032870;response to hormone#GO:0009725;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG192851|UniProtKB=T1FUC9 T1FUC9 20212425 PTHR10671:SF108 EPITHELIAL MEMBRANE PROTEIN-RELATED CLAUDIN FAMILY PROTEIN-RELATED cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG190612|UniProtKB=T1FS48 T1FS48 20211645 PTHR13620:SF104 3-5 EXONUCLEASE EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;nuclease activity#GO:0004518;3'-5' exonuclease activity#GO:0008408;exonuclease activity#GO:0004527;catalytic activity#GO:0003824 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG178095|UniProtKB=T1FCQ5 T1FCQ5 20206604 PTHR33539:SF1 UPF0764 PROTEIN C16ORF89 UPF0764 PROTEIN C16ORF89 HELRO|EnsemblGenome=HelroG177704|UniProtKB=T1FC40 T1FC40 20206389 PTHR23309:SF49 3-HYDROXYACYL-COA DEHYROGENASE PEROXISOMAL BIFUNCTIONAL ENZYME oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;lipid oxidation#GO:0034440;cellular metabolic process#GO:0044237;lipid catabolic process#GO:0016042;lipid modification#GO:0030258;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;fatty acid catabolic process#GO:0009062;primary metabolic process#GO:0044238;organic acid catabolic process#GO:0016054;fatty acid metabolic process#GO:0006631;small molecule catabolic process#GO:0044282;fatty acid beta-oxidation#GO:0006635;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;cellular lipid metabolic process#GO:0044255;cellular lipid catabolic process#GO:0044242;carboxylic acid metabolic process#GO:0019752;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG167542|UniProtKB=T1EZG9 T1EZG9 20201969 PTHR13465:SF2 UPF0183 PROTEIN PHAGOSOME ASSEMBLY FACTOR 1 HELRO|EnsemblGenome=HelroG174556|UniProtKB=T1F892 T1F892 20205041 PTHR12472:SF0 RAB3-GAP REGULATORY DOMAIN RAB3 GTPASE-ACTIVATING PROTEIN NON-CATALYTIC SUBUNIT biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;regulation of GTPase activity#GO:0043087;regulation of molecular function#GO:0065009 G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG179998|UniProtKB=T1FFB5 T1FFB5 20207514 PTHR46601:SF1 ULP_PROTEASE DOMAIN-CONTAINING PROTEIN ADF-H DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG93977|UniProtKB=T1G8Y4 T1G8Y4 20217531 PTHR10196:SF69 SUGAR KINASE GLYCEROL KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;kinase activity#GO:0016301 organic hydroxy compound metabolic process#GO:1901615;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;alcohol metabolic process#GO:0006066;cellular process#GO:0009987;carbohydrate metabolic process#GO:0005975;phosphorus metabolic process#GO:0006793;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 carbohydrate kinase#PC00065 HELRO|EnsemblGenome=HelroG185092|UniProtKB=T1FMD9 T1FMD9 20209988 PTHR47977:SF107 RAS-RELATED PROTEIN RAB RAB GTPASE-RELATED GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;transport#GO:0006810 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG162491|UniProtKB=T1ESQ9 T1ESQ9 20199609 PTHR13473:SF0 MITOCHONDRIAL RIBOSOMAL PROTEIN L48 LARGE RIBOSOMAL SUBUNIT PROTEIN ML48 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;organellar ribosome#GO:0000313;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG84578|UniProtKB=T1G5K5 T1G5K5 20216352 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG94361|UniProtKB=T1G905 T1G905 20217552 PTHR11630:SF46 DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER DNA REPLICATION LICENSING FACTOR MCM3-RELATED ATP-dependent activity, acting on DNA#GO:0008094;nucleic acid binding#GO:0003676;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;single-stranded DNA binding#GO:0003697;DNA binding#GO:0003677;catalytic activity, acting on a nucleic acid#GO:0140640;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097;single-stranded DNA helicase activity#GO:0017116 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;double-strand break repair#GO:0006302;cell cycle process#GO:0022402;nucleobase-containing compound metabolic process#GO:0006139;mitotic cell cycle process#GO:1903047;DNA damage response#GO:0006974;mitotic cell cycle#GO:0000278;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;recombinational repair#GO:0000725;DNA-templated DNA replication#GO:0006261;cell cycle DNA replication#GO:0044786;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;nuclear DNA replication#GO:0033260;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;double-strand break repair via homologous recombination#GO:0000724;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;mitotic DNA replication initiation#GO:1902975;response to stress#GO:0006950;double-strand break repair via break-induced replication#GO:0000727;mitotic DNA replication#GO:1902969;cell cycle#GO:0007049;cellular response to stress#GO:0033554;DNA replication#GO:0006260;DNA replication initiation#GO:0006270;DNA strand elongation involved in DNA replication#GO:0006271;DNA metabolic process#GO:0006259 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;MCM complex#GO:0042555;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG89924|UniProtKB=T1G7J1 T1G7J1 20217038 PTHR45646:SF11 SERINE/THREONINE-PROTEIN KINASE DOA-RELATED SERINE_THREONINE-PROTEIN KINASE DOA transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG184323|UniProtKB=T1FKZ9 T1FKZ9 20209498 PTHR46600:SF1 THAP DOMAIN-CONTAINING THAP DOMAIN-CONTAINING PROTEIN 1 zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG112374|UniProtKB=T1EFJ2 T1EFJ2 20195344 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG65374|UniProtKB=T1FY67 T1FY67 20213765 PTHR10809:SF6 VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN AT11025P-RELATED localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organelle localization#GO:0051640;endoplasmic reticulum organization#GO:0007029;membrane organization#GO:0061024;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;plasma membrane#GO:0005886;endoplasmic reticulum membrane#GO:0005789 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG145007|UniProtKB=T1EJI0 T1EJI0 20196730 PTHR11267:SF204 T-BOX PROTEIN-RELATED SPADETAIL sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cell fate commitment#GO:0045165;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;cell fate specification#GO:0001708;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HELRO|EnsemblGenome=HelroG155958|UniProtKB=T1ELP6 T1ELP6 20197496 PTHR45928:SF1 RE38146P RE38146P HELRO|EnsemblGenome=HelroG177759|UniProtKB=T1FC74 T1FC74 20206423 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG180680|UniProtKB=T1FG59 T1FG59 20207808 PTHR42912:SF83 METHYLTRANSFERASE METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN methyltransferase activity#GO:0008168;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824 methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG168967|UniProtKB=T1F174 T1F174 20202574 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG185980|UniProtKB=T1FNI4 T1FNI4 20210381 PTHR15907:SF223 DUF614 FAMILY PROTEIN-RELATED SUBFAMILY NOT NAMED HELRO|EnsemblGenome=HelroG63524|UniProtKB=T1FXG9 T1FXG9 20213517 PTHR24416:SF527 TYROSINE-PROTEIN KINASE RECEPTOR PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of phosphate metabolic process#GO:0019220;positive regulation of cellular metabolic process#GO:0031325;developmental process#GO:0032502;regulation of signaling#GO:0023051;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;regulation of phosphorus metabolic process#GO:0051174;positive regulation of transferase activity#GO:0051347;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;regulation of signal transduction#GO:0009966;positive regulation of biological process#GO:0048518;signaling#GO:0023052;regulation of kinase activity#GO:0043549;transmembrane receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cell communication#GO:0010646;positive regulation of phosphorylation#GO:0042327;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;multicellular organism development#GO:0007275;positive regulation of phosphorus metabolic process#GO:0010562;cell communication#GO:0007154;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;response to stimulus#GO:0050896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of phosphate metabolic process#GO:0045937;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of kinase activity#GO:0033674;multicellular organismal process#GO:0032501;regulation of transferase activity#GO:0051338;regulation of phosphorylation#GO:0042325;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG191248|UniProtKB=T1FSS6 T1FSS6 20211873 PTHR12688:SF0 DYNEIN LIGHT INTERMEDIATE CHAIN DYNEIN LIGHT INTERMEDIATE CHAIN protein binding#GO:0005515;binding#GO:0005488 cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;microtubule cytoskeleton organization#GO:0000226;microtubule-based movement#GO:0007018;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule associated complex#GO:0005875;microtubule organizing center#GO:0005815;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;microtubule cytoskeleton#GO:0015630;dynein complex#GO:0030286;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic dynein complex#GO:0005868;centrosome#GO:0005813;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Dynein complex#P00774 HELRO|EnsemblGenome=HelroG104527|UniProtKB=T1EDM1 T1EDM1 20194673 PTHR19134:SF562 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE PROTEIN-TYROSINE-PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein tyrosine phosphatase activity#GO:0004725;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG83227|UniProtKB=T1G524 T1G524 20216172 PTHR10848:SF0 MEIOTIC RECOMBINATION PROTEIN SPO11 MEIOTIC RECOMBINATION PROTEIN SPO11 endodeoxyribonuclease#PC00093 HELRO|EnsemblGenome=HelroG113778|UniProtKB=T1EFW3 T1EFW3 20195465 PTHR10997:SF18 IMPORTIN-7, 8, 11 D-IMPORTIN 7_RANBP7 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;protein import into nucleus#GO:0006606;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;protein localization to organelle#GO:0033365;intracellular transport#GO:0046907;nuclear transport#GO:0051169;import into nucleus#GO:0051170 envelope#GO:0031975;cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transporter#PC00227 HELRO|EnsemblGenome=HelroG194276|UniProtKB=T1FVW0 T1FVW0 20212956 PTHR10677:SF3 UBIQUILIN FI07626P-RELATED protein binding#GO:0005515;binding#GO:0005488;polyubiquitin modification-dependent protein binding#GO:0031593;modification-dependent protein binding#GO:0140030 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG74301|UniProtKB=T1G1P5 T1G1P5 20214993 PTHR24112:SF9 LEUCINE-RICH REPEAT, ISOFORM F-RELATED PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 37 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG173497|UniProtKB=T1F6W3 T1F6W3 20204562 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG178669|UniProtKB=T1FDJ4 T1FDJ4 20206893 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG180666|UniProtKB=T1FG52 T1FG52 20207801 PTHR42918:SF9 LYSYL-TRNA SYNTHETASE LYSINE--TRNA LIGASE catalytic activity, acting on RNA#GO:0140098;tRNA binding#GO:0000049;ligase activity#GO:0016874;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;catalytic activity, acting on a nucleic acid#GO:0140640 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;peptide biosynthetic process#GO:0043043;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HELRO|EnsemblGenome=HelroG84705|UniProtKB=T1G5M6 T1G5M6 20216373 PTHR16719:SF0 CYTOCHROME C OXIDASE COPPER CHAPERONE CYTOCHROME C OXIDASE COPPER CHAPERONE chaperone#PC00072 HELRO|EnsemblGenome=HelroG148094|UniProtKB=T1EK46 T1EK46 20196946 PTHR24068:SF33 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2Q 2 ISOFORM 1 ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG191142|UniProtKB=T1FSN0 T1FSN0 20211827 PTHR18945:SF914 NEUROTRANSMITTER GATED ION CHANNEL NEUROTRANSMITTER-GATED ION-CHANNEL LIGAND-BINDING DOMAIN-CONTAINING PROTEIN transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834 transmembrane transport#GO:0055085;transport#GO:0006810;regulation of membrane potential#GO:0042391;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;localization#GO:0051179;regulation of biological process#GO:0050789;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission#GO:0007268;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;synaptic signaling#GO:0099536;monoatomic ion transport#GO:0006811;signaling#GO:0023052;cell-cell signaling#GO:0007267 cell junction#GO:0030054;synapse#GO:0045202;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;neuron projection#GO:0043005 ligand-gated ion channel#PC00141;ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG176189|UniProtKB=T1FAA0 T1FAA0 20205749 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157135|UniProtKB=T1EM70 T1EM70 20197670 PTHR42854:SF3 EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED tRNA binding#GO:0000049;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG109533|UniProtKB=T1EEU5 T1EEU5 20195097 PTHR45827:SF1 SORTING NEXIN SORTING NEXIN lipid binding#GO:0008289;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;binding#GO:0005488 endosomal transport#GO:0016197;cellular localization#GO:0051641;membrane organization#GO:0061024;plasma membrane organization#GO:0007009;transport#GO:0006810;endocytosis#GO:0006897;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;import into cell#GO:0098657 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG164053|UniProtKB=T1EUU3 T1EUU3 20200343 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178985|UniProtKB=T1FE05 T1FE05 20207054 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG110223|UniProtKB=T1EF06 T1EF06 20195158 PTHR23122:SF7 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK PERIPHERAL PLASMA MEMBRANE PROTEIN CASK protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 regulation of cell communication#GO:0010646;cellular localization#GO:0051641;macromolecule localization#GO:0033036;regulation of signaling#GO:0023051;regulation of localization#GO:0032879;regulation of secretion by cell#GO:1903530;cellular process#GO:0009987;regulation of neurotransmitter secretion#GO:0046928;protein localization#GO:0008104;regulation of biological process#GO:0050789;localization#GO:0051179;regulation of transport#GO:0051049;cellular macromolecule localization#GO:0070727;regulation of cellular process#GO:0050794;regulation of secretion#GO:0051046;modulation of chemical synaptic transmission#GO:0050804;biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177 cell junction#GO:0030054;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911;anchoring junction#GO:0070161;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 Parkinson disease#P00049>CASK#P01232;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CaMK#P00847 HELRO|EnsemblGenome=HelroG182418|UniProtKB=T1FI59 T1FI59 20208508 PTHR31780:SF10 STRESS RESPONSE PROTEIN NST1-RELATED LD36051P HELRO|EnsemblGenome=HelroG184502|UniProtKB=T1FLC3 T1FLC3 20209622 PTHR46113:SF1 SNAC DOMAIN-CONTAINING PROTEIN PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG65752|UniProtKB=T1FYC3 T1FYC3 20213821 PTHR11562:SF84 CATION EFFLUX PROTEIN/ ZINC TRANSPORTER LD05335P inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075 localization#GO:0051179;response to stimulus#GO:0050896;metal ion transport#GO:0030001;response to chemical#GO:0042221;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;transition metal ion transport#GO:0000041;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG80719|UniProtKB=T1G444 T1G444 20215842 PTHR24300:SF403 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 306A1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;tetrapyrrole binding#GO:0046906;steroid hydroxylase activity#GO:0008395;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;heme binding#GO:0020037 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG185262|UniProtKB=T1FMK7 T1FMK7 20210056 PTHR45761:SF1 EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG80599|UniProtKB=T1G426 T1G426 20215824 PTHR24543:SF334 MULTICOPPER OXIDASE-RELATED F5_8 TYPE C DOMAIN-CONTAINING PROTEIN oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG151695|UniProtKB=T1EKL9 T1EKL9 20197119 PTHR11158:SF30 MSF1/PX19 RELATED SEC14-LIKE PROTEIN 1 phospholipid transporter activity#GO:0005548;lipid transfer activity#GO:0120013;transporter activity#GO:0005215;lipid transporter activity#GO:0005319 localization#GO:0051179;organic substance transport#GO:0071702;organophosphate ester transport#GO:0015748;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;lipid localization#GO:0010876;phospholipid transport#GO:0015914;lipid transport#GO:0006869 envelope#GO:0031975;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;mitochondrial envelope#GO:0005740;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;mitochondrial intermembrane space#GO:0005758;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG165799|UniProtKB=T1EXA8 T1EXA8 20201208 PTHR14949:SF54 EGF-LIKE-DOMAIN, MULTIPLE 7, 8 VWFD DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 anatomical structure development#GO:0048856;developmental process#GO:0032502 cell surface#GO:0009986;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG191819|UniProtKB=T1FTC3 T1FTC3 20212070 PTHR23220:SF133 INTEGRIN ALPHA INTEGRIN ALPHA-PS2 cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;integrin binding#GO:0005178;binding#GO:0005488;signaling receptor binding#GO:0005102 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;cell adhesion mediated by integrin#GO:0033627;cell-cell adhesion#GO:0098609;cell communication#GO:0007154;cell adhesion#GO:0007155;cell-substrate adhesion#GO:0031589;cellular process#GO:0009987;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cell-matrix adhesion#GO:0007160;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;integrin-mediated signaling pathway#GO:0007229;biological regulation#GO:0065007;signaling#GO:0023052 receptor complex#GO:0043235;membrane protein complex#GO:0098796;external side of plasma membrane#GO:0009897;cell surface#GO:0009986;protein-containing complex#GO:0032991;plasma membrane signaling receptor complex#GO:0098802;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;side of membrane#GO:0098552;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;integrin#PC00126 Integrin signalling pathway#P00034>Integrin alpha#P00941 HELRO|EnsemblGenome=HelroG173534|UniProtKB=T1F6Y4 T1F6Y4 20204583 PTHR15666:SF1 COMM DOMAIN CONTAINING PROTEIN 5 COMM DOMAIN-CONTAINING PROTEIN 5 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 protein-binding activity modulator#PC00095 HELRO|EnsemblGenome=HelroG82775|UniProtKB=T1G4W3 T1G4W3 20216111 PTHR10605:SF65 HEPARAN SULFATE SULFOTRANSFERASE GH20068P sulfotransferase activity#GO:0008146;transferase activity#GO:0016740;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity#GO:0003824 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG178944|UniProtKB=T1FDX8 T1FDX8 20207027 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG88642|UniProtKB=T1G747 T1G747 20216894 PTHR24115:SF576 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF17 pyrophosphatase activity#GO:0016462;cytoskeletal protein binding#GO:0008092;microtubule motor activity#GO:0003777;tubulin binding#GO:0015631;ATP-dependent activity#GO:0140657;binding#GO:0005488;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;cytoskeletal motor activity#GO:0003774;microtubule binding#GO:0008017;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;microtubule associated complex#GO:0005875;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG138329|UniProtKB=T1EIT9 T1EIT9 20196489 PTHR11849:SF191 ETS ECDYSONE-INDUCED PROTEIN 74EF ISOFORM B transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 PDGF signaling pathway#P00047>Ets#P01167 HELRO|EnsemblGenome=HelroG103151|UniProtKB=T1EDE4 T1EDE4 20194596 PTHR10333:SF89 INHIBITOR OF GROWTH PROTEIN INHIBITOR OF GROWTH PROTEIN protein binding#GO:0005515;methylated histone binding#GO:0035064;histone binding#GO:0042393;binding#GO:0005488;modification-dependent protein binding#GO:0140030 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG182151|UniProtKB=T1FHU1 T1FHU1 20208390 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178814|UniProtKB=T1FDS2 T1FDS2 20206971 PTHR46513:SF13 VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG83132|UniProtKB=T1G508 T1G508 20216156 PTHR12375:SF30 RNA-BINDING PROTEIN LUC7-RELATED LD04387P nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;mRNA splice site recognition#GO:0006376;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375;spliceosomal complex assembly#GO:0000245 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;U1 snRNP#GO:0005685;U2-type spliceosomal complex#GO:0005684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;U2-type prespliceosome#GO:0071004;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG106059|UniProtKB=T1EDZ8 T1EDZ8 20194800 PTHR11468:SF13 GLYCOGEN PHOSPHORYLASE GLYCOGEN PHOSPHORYLASE transferase activity#GO:0016740;small molecule binding#GO:0036094;glycosyltransferase activity#GO:0016757;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168;hexosyltransferase activity#GO:0016758 glucan metabolic process#GO:0044042;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;glycogen metabolic process#GO:0005977;generation of precursor metabolites and energy#GO:0006091;cellular metabolic process#GO:0044237;cellular process#GO:0009987;energy derivation by oxidation of organic compounds#GO:0015980;primary metabolic process#GO:0044238;polysaccharide metabolic process#GO:0005976;carbohydrate catabolic process#GO:0016052;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;energy reserve metabolic process#GO:0006112;carbohydrate metabolic process#GO:0005975;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HELRO|EnsemblGenome=HelroG182628|UniProtKB=T1FII0 T1FII0 20208629 PTHR46888:SF1 ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED RIBONUCLEASE H HELRO|EnsemblGenome=HelroG185444|UniProtKB=T1FMU1 T1FMU1 20210140 PTHR13242:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;translation#GO:0006412;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;translational initiation#GO:0006413;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;eukaryotic translation initiation factor 3 complex#GO:0005852;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG182276|UniProtKB=T1FI08 T1FI08 20208457 PTHR23227:SF67 BUCENTAUR RELATED CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE HELRO|EnsemblGenome=HelroG185628|UniProtKB=T1FN23 T1FN23 20210222 PTHR43920:SF5 CHLORIDE INTRACELLULAR CHANNEL, ISOFORM A CHLORIDE INTRACELLULAR CHANNEL CLIC inorganic molecular entity transmembrane transporter activity#GO:0015318;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;inorganic anion transmembrane transporter activity#GO:0015103;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216 localization#GO:0051179;chloride transport#GO:0006821;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;inorganic anion transport#GO:0015698;monoatomic anion transport#GO:0006820;transport#GO:0006810 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG171432|UniProtKB=T1F498 T1F498 20203647 PTHR24096:SF149 LONG-CHAIN-FATTY-ACID--COA LIGASE AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED ligase activity#GO:0016874;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 metabolite interconversion enzyme#PC00262;ligase#PC00142 HELRO|EnsemblGenome=HelroG74789|UniProtKB=T1G1Z2 T1G1Z2 20215090 PTHR12629:SF0 DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;phosphatase#PC00181;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG183929|UniProtKB=T1FKB2 T1FKB2 20209261 PTHR10390:SF61 HOMEOBOX PROTEIN SIX HOMEOBOX PROTEIN SIX2 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HELRO|EnsemblGenome=HelroG189158|UniProtKB=T1FQQ4 T1FQQ4 20211151 PTHR11937:SF526 ACTIN ACTIN, CYTOPLASMIC 1-RELATED intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 actin and actin related protein#PC00039;cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Integrin signalling pathway#P00034>Actin#P00944;Alzheimer disease-presenilin pathway#P00004>actin#P00114;Nicotinic acetylcholine receptor signaling pathway#P00044>Actin#P01090;Huntington disease#P00029>Actin#P00807;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>F-actin#P00858;Cadherin signaling pathway#P00012>F-actin#P00470;Cytoskeletal regulation by Rho GTPase#P00016>Actin#P00512 HELRO|EnsemblGenome=HelroG180186|UniProtKB=T1FFJ9 T1FFJ9 20207598 PTHR14592:SF12 UNCHARACTERIZED FAM3 ILEI_PANDER DOMAIN-CONTAINING PROTEIN extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HELRO|EnsemblGenome=HelroG179198|UniProtKB=T1FEC5 T1FEC5 20207174 PTHR12694:SF8 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;gene expression#GO:0010467;cellular metabolic process#GO:0044237;RNA biosynthetic process#GO:0032774;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;transcription by RNA polymerase II#GO:0006366;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 RNA metabolism protein#PC00031;general transcription factor#PC00259 General transcription regulation#P00023>TFIIA complex#P00662;Transcription regulation by bZIP transcription factor#P00055>TFIIA complex#P01390 HELRO|EnsemblGenome=HelroG165072|UniProtKB=T1EW91 T1EW91 20200841 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG192348|UniProtKB=T1FTU7 T1FTU7 20212244 PTHR33995:SF7 PROTEIN CBG18546 BURSICON SUBUNIT ALPHA-RELATED HELRO|EnsemblGenome=HelroG192809|UniProtKB=T1FUB7 T1FUB7 20212413 PTHR22917:SF6 HEMOPEXIN DOMAIN-CONTAINING PROTEIN EG:8D8.2 PROTEIN-RELATED HELRO|EnsemblGenome=HelroG178635|UniProtKB=T1FDH2 T1FDH2 20206871 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG85671|UniProtKB=T1G612 T1G612 20216509 PTHR21192:SF2 NUCLEAR PROTEIN E3-3 NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3 HELRO|EnsemblGenome=HelroG161801|UniProtKB=T1ERX5 T1ERX5 20199325 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG185556|UniProtKB=T1FMZ3 T1FMZ3 20210192 PTHR23055:SF178 CALCIUM BINDING PROTEINS NEUROCALCIN HOMOLOG cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG168363|UniProtKB=T1F0H2 T1F0H2 20202322 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG180792|UniProtKB=T1FGA2 T1FGA2 20207851 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG182517|UniProtKB=T1FIB1 T1FIB1 20208560 PTHR19302:SF27 GAMMA TUBULIN COMPLEX PROTEIN GAMMA-TUBULIN COMPLEX COMPONENT 4 cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;meiotic cell cycle#GO:0051321;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule polymerization or depolymerization#GO:0031109;chromosome segregation#GO:0007059;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;reproduction#GO:0000003;microtubule polymerization#GO:0046785;microtubule-based process#GO:0007017;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;supramolecular fiber organization#GO:0097435;sexual reproduction#GO:0019953;protein polymerization#GO:0051258;spindle assembly#GO:0051225;reproductive process#GO:0022414;cell cycle#GO:0007049;cytoskeleton organization#GO:0007010;spindle organization#GO:0007051;non-membrane-bounded organelle assembly#GO:0140694;microtubule nucleation#GO:0007020;cytoplasmic microtubule organization#GO:0031122 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG91302|UniProtKB=T1G822 T1G822 20217219 PTHR11735:SF6 TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG158422|UniProtKB=T1EMR9 T1EMR9 20197869 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG65295|UniProtKB=T1FY56 T1FY56 20213754 PTHR11909:SF300 CASEIN KINASE-RELATED TAU-TUBULIN KINASE HOMOLOG ASATOR transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cell communication#GO:0007154;protein phosphorylation#GO:0006468;cellular process#GO:0009987;peptidyl-serine phosphorylation#GO:0018105;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;peptidyl-serine modification#GO:0018209;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;signaling#GO:0023052;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Parkinson disease#P00049>Casein kinase I#P01242 HELRO|EnsemblGenome=HelroG189432|UniProtKB=T1FR19 T1FR19 20211266 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG135646|UniProtKB=T1EI99 T1EI99 20196299 PTHR23235:SF60 KRUEPPEL-LIKE TRANSCRIPTION FACTOR STRIPE, ISOFORM D sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG191080|UniProtKB=T1FSK6 T1FSK6 20211803 PTHR14911:SF1 THUMP DOMAIN-CONTAINING THUMP DOMAIN-CONTAINING PROTEIN 2 tRNA methyltransferase activity#GO:0008175;catalytic activity, acting on RNA#GO:0140098;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;RNA methyltransferase activity#GO:0008173 cellular aromatic compound metabolic process#GO:0006725;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;tRNA processing#GO:0008033;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;macromolecule methylation#GO:0043414;tRNA methylation#GO:0030488;organic cyclic compound metabolic process#GO:1901360;methylation#GO:0032259;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;RNA methylation#GO:0001510;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 RNA metabolism protein#PC00031;RNA methyltransferase#PC00033 HELRO|EnsemblGenome=HelroG166083|UniProtKB=T1EXQ4 T1EXQ4 20201354 PTHR31383:SF2 OXIDATIVE STRESS-RESPONSE SERINE-RICH PROTEIN 1 OXIDATIVE STRESS-RESPONSIVE SERINE-RICH PROTEIN 1 response to stimulus#GO:0050896;cellular response to oxygen-containing compound#GO:1901701;cellular response to stimulus#GO:0051716;response to stress#GO:0006950;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;response to chemical#GO:0042221;cellular response to oxidative stress#GO:0034599;response to reactive oxygen species#GO:0000302;response to oxidative stress#GO:0006979;cellular process#GO:0009987;cellular response to stress#GO:0033554 HELRO|EnsemblGenome=HelroG170304|UniProtKB=T1F2W6 T1F2W6 20203165 PTHR44324:SF3 WD40 REPEAT DOMAIN 95 WD REPEAT-CONTAINING PROTEIN 49-LIKE HELRO|EnsemblGenome=HelroG181506|UniProtKB=T1FH26 T1FH26 20208125 PTHR24104:SF57 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED BEE-MILK PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein polyubiquitination#GO:0000209;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG66271|UniProtKB=T1FYI9 T1FYI9 20213887 PTHR44566:SF1 TRANSDUCIN/WD40 REPEAT-LIKE SUPERFAMILY PROTEIN WD REPEAT-CONTAINING PROTEIN 25 HELRO|EnsemblGenome=HelroG92607|UniProtKB=T1G8I9 T1G8I9 20217386 PTHR11537:SF252 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;voltage-gated channel activity#GO:0022832;potassium ion transmembrane transporter activity#GO:0015079;delayed rectifier potassium channel activity#GO:0005251;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated potassium channel activity#GO:0005249;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;regulation of membrane potential#GO:0042391;action potential#GO:0001508;inorganic ion transmembrane transport#GO:0098660;cellular process#GO:0009987;localization#GO:0051179;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;potassium ion transmembrane transport#GO:0071805;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG160028|UniProtKB=T1EPP1 T1EPP1 20198541 PTHR10258:SF8 CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA CALCIUM-ACTIVATED POTASSIUM CHANNEL BK ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;molecular function regulator activity#GO:0098772;transporter regulator activity#GO:0141108;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic ion-gated channel activity#GO:0022839;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium-activated cation channel activity#GO:0005227;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;potassium channel regulator activity#GO:0015459;ligand-gated monoatomic cation channel activity#GO:0099094;channel regulator activity#GO:0016247;monoatomic ion channel activity#GO:0005216;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 detection of stimulus#GO:0051606;response to stimulus#GO:0050896;response to chemical#GO:0042221;detection of chemical stimulus#GO:0009593 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG99384|UniProtKB=T1G9S4 T1G9S4 20217820 PTHR15422:SF45 OS05G0565100 PROTEIN CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG146547|UniProtKB=T1EJT1 T1EJT1 20196831 PTHR11544:SF60 COLD SHOCK DOMAIN CONTAINING PROTEINS LD37574P nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 HELRO|EnsemblGenome=HelroG189219|UniProtKB=T1FQT3 T1FQT3 20211180 PTHR46077:SF5 E3 UBIQUITIN-PROTEIN LIGASE TOPORS RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein monoubiquitination#GO:0006513;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG190893|UniProtKB=T1FSE4 T1FSE4 20211741 PTHR12659:SF7 RHO-TYPE GTPASE ACTIVATING PROTEIN CROSSVEINLESS C, ISOFORM C nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of cell communication#GO:0010646;regulation of Rho protein signal transduction#GO:0035023;regulation of signaling#GO:0023051;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of intracellular signal transduction#GO:1902531;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;regulation of cellular process#GO:0050794;organelle organization#GO:0006996;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG190932|UniProtKB=T1FSF7 T1FSF7 20211754 PTHR12984:SF16 SCY1-RELATED S/T PROTEIN KINASE-LIKE BLACK MATCH, ISOFORM H non-receptor serine/threonine protein kinase#PC00167 HELRO|EnsemblGenome=HelroG189261|UniProtKB=T1FQV9 T1FQV9 20211206 PTHR18966:SF422 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1-RELATED signaling receptor activity#GO:0038023;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;ligand-gated channel activity#GO:0022834 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019 HELRO|EnsemblGenome=HelroG179678|UniProtKB=T1FF08 T1FF08 20207407 PTHR12483:SF27 SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS COPPER TRANSPORT PROTEIN CTR1 inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG173920|UniProtKB=T1F7D8 T1F7D8 20209519 PTHR16148:SF14 NF-KAPPA-B-REPRESSING FACTOR-RELATED MYND-TYPE DOMAIN-CONTAINING PROTEIN DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG159100|UniProtKB=T1ENL2 T1ENL2 20198162 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG74048|UniProtKB=T1G1L6 T1G1L6 20214964 PTHR45695:SF26 LEUCOKININ RECEPTOR-RELATED NEUROPEPTIDE CCHAMIDE-1 RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG68539|UniProtKB=T1FZG5 T1FZG5 20214213 PTHR46461:SF1 KELCH DOMAIN-CONTAINING PROTEIN 3 KELCH DOMAIN-CONTAINING PROTEIN 3 protein-containing complex binding#GO:0044877;binding#GO:0005488;chromatin binding#GO:0003682 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG167728|UniProtKB=T1EZQ5 T1EZQ5 20202055 PTHR10838:SF20 SYNAPTOGYRIN SYNAPTOGYRIN synaptic vesicle membrane#GO:0030672;bounding membrane of organelle#GO:0098588;presynapse#GO:0098793;synapse#GO:0045202;synaptic vesicle#GO:0008021;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;cell junction#GO:0030054;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;vesicle membrane#GO:0012506;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;transport vesicle membrane#GO:0030658;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;transport vesicle#GO:0030133;cytoplasmic vesicle membrane#GO:0030659;secretory vesicle#GO:0099503;neuromuscular junction#GO:0031594 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG194826|UniProtKB=T1FWG4 T1FWG4 20213159 PTHR46876:SF1 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 11 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 11 HELRO|EnsemblGenome=HelroG95981|UniProtKB=T1G996 T1G996 20217643 PTHR22792:SF140 LUPUS LA PROTEIN-RELATED ACHILLES, ISOFORM A nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG176820|UniProtKB=T1FAY0 T1FAY0 20205979 PTHR10809:SF6 VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN AT11025P-RELATED localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organelle localization#GO:0051640;endoplasmic reticulum organization#GO:0007029;membrane organization#GO:0061024;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;plasma membrane#GO:0005886;endoplasmic reticulum membrane#GO:0005789 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG179229|UniProtKB=T1FEE1 T1FEE1 20207190 PTHR13667:SF5 HOMOLOC-13 WD REPEAT-CONTAINING AND PLANAR CELL POLARITY EFFECTOR PROTEIN FRITZ HOMOLOG HELRO|EnsemblGenome=HelroG191239|UniProtKB=T1FSS1 T1FSS1 20211868 PTHR18839:SF0 MITOTIC INTERACTOR AND SUBSTRATE OF PLK1 MISP FAMILY MEMBER MITOTIC INTERACTOR AND SUBSTRATE OF PLK1 ISOFORM X1-RELATED HELRO|EnsemblGenome=HelroG161297|UniProtKB=T1ERB1 T1ERB1 20199111 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG193600|UniProtKB=T1FV59 T1FV59 20212705 PTHR21077:SF5 EME1 PROTEIN CROSSOVER JUNCTION ENDONUCLEASE MMS4 HELRO|EnsemblGenome=HelroG192733|UniProtKB=T1FU87 T1FU87 20212383 PTHR22600:SF21 BETA-HEXOSAMINIDASE BETA-HEXOSAMINIDASE A hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 glycosaminoglycan metabolic process#GO:0030203;carbohydrate derivative metabolic process#GO:1901135;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;aminoglycan metabolic process#GO:0006022;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cellular anatomical entity#GO:0110165;membrane#GO:0016020 glycosidase#PC00110;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG75857|UniProtKB=T1G2B4 T1G2B4 20215212 PTHR45712:SF30 AGAP008170-PA LRRNT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG68975|UniProtKB=T1FZM8 T1FZM8 20214276 PTHR24390:SF237 ZINC FINGER PROTEIN FI23536P1-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG180902|UniProtKB=T1FGE3 T1FGE3 20207892 PTHR22902:SF9 SESQUIPEDALIAN PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY J MEMBER 1 endosomal transport#GO:0016197;cellular localization#GO:0051641;macromolecule metabolic process#GO:0043170;transport#GO:0006810;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;endosome organization#GO:0007032;establishment of localization#GO:0051234;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;vesicle organization#GO:0016050;intracellular transport#GO:0046907;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 trans-Golgi network#GO:0005802;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;Golgi apparatus#GO:0005794;early endosome#GO:0005769;organelle subcompartment#GO:0031984;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;endomembrane system#GO:0012505;recycling endosome#GO:0055037;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG180819|UniProtKB=T1FGB6 T1FGB6 20207865 PTHR22802:SF379 C-TYPE LECTIN SUPERFAMILY MEMBER CHONDROITIN SULFATE PROTEOGLYCAN 2 ISOFORM X1 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG188605|UniProtKB=T1FQ62 T1FQ62 20210959 PTHR24070:SF263 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY RAS-RELATED PROTEIN RAP1 GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 small GTPase#PC00208;G-protein#PC00020 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Rap1#P00703;Integrin signalling pathway#P00034>Rap1#P00906;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Rap1#P00734 HELRO|EnsemblGenome=HelroG181046|UniProtKB=T1FGK1 T1FGK1 20207950 PTHR24217:SF0 PUTATIVE-RELATED PDZ DOMAIN-CONTAINING PROTEIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;actin binding#GO:0003779;binding#GO:0005488 positive regulation of organelle organization#GO:0010638;regulation of organelle organization#GO:0033043;regulation of actin filament organization#GO:0110053;regulation of cellular component organization#GO:0051128;positive regulation of cellular process#GO:0048522;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of cytoskeleton organization#GO:0051493;positive regulation of actin filament bundle assembly#GO:0032233;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament-based process#GO:0032970;positive regulation of cellular component biogenesis#GO:0044089;regulation of actin filament bundle assembly#GO:0032231;positive regulation of biological process#GO:0048518 supramolecular complex#GO:0099080;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;Z disc#GO:0030018;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;organelle#GO:0043226;contractile fiber#GO:0043292;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;sarcomere#GO:0030017;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;myofibril#GO:0030016;I band#GO:0031674 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG166363|UniProtKB=T1EY21 T1EY21 20201471 PTHR46560:SF5 CYPHER, ISOFORM B CYPHER, ISOFORM B HELRO|EnsemblGenome=HelroG181378|UniProtKB=T1FGX8 T1FGX8 20208077 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG177268|UniProtKB=T1FBF6 T1FBF6 20206155 PTHR14454:SF11 GRB2-ASSOCIATED AND REGULATOR OF MAPK PROTEIN FAMILY MEMBER SERRANO, ISOFORM F HELRO|EnsemblGenome=HelroG109402|UniProtKB=T1EET4 T1EET4 20195086 PTHR43884:SF12 ACYL-COA DEHYDROGENASE ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 dehydrogenase#PC00092;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG175645|UniProtKB=T1F9G8 T1F9G8 20205467 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG192737|UniProtKB=T1FU88 T1FU88 20212384 PTHR11588:SF4 TUBULIN TUBULIN DELTA CHAIN carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;structural molecule activity#GO:0005198;small molecule binding#GO:0036094;binding#GO:0005488;organic cyclic compound binding#GO:0097159;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167;structural constituent of cytoskeleton#GO:0005200 cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;microtubule-based process#GO:0007017;organelle organization#GO:0006996;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;cell cycle#GO:0007049;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 tubulin#PC00228;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG143940|UniProtKB=T1EJD1 T1EJD1 20196681 PTHR16320:SF24 SPHINGOMYELINASE FAMILY MEMBER PHOSPHODIESTERASE, PUTATIVE-RELATED hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;phospholipase activity#GO:0004620;catalytic activity#GO:0003824 HELRO|EnsemblGenome=HelroG185265|UniProtKB=T1FML0 T1FML0 20210059 PTHR16505:SF8 PROTEIN LZIC PROTEIN LZIC HELRO|EnsemblGenome=HelroG80714|UniProtKB=T1G442 T1G442 20215840 PTHR24179:SF29 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12 LD46604P phosphatase regulator activity#GO:0019208;enzyme inhibitor activity#GO:0004857;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG112893|UniProtKB=T1EFN0 T1EFN0 20195382 PTHR12124:SF47 POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED EXOSOME COMPONENT 10 HELRO|EnsemblGenome=HelroG169404|UniProtKB=T1F1W5 T1F1W5 20202815 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG97497|UniProtKB=T1G9H4 T1G9H4 20217721 PTHR10953:SF4 UBIQUITIN-ACTIVATING ENZYME E1 UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN ligase activity#GO:0016874;transferase activity#GO:0016740;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877;nucleotidyltransferase activity#GO:0016779;thiosulfate sulfurtransferase activity#GO:0004792;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity, acting on a protein#GO:0140096;sulfurtransferase activity#GO:0016783 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;cellular response to stimulus#GO:0051716;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;cellular process#GO:0009987;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;response to stimulus#GO:0050896;DNA damage response#GO:0006974;response to stress#GO:0006950;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E1#P01492 HELRO|EnsemblGenome=HelroG168674|UniProtKB=T1F0U7 T1F0U7 20202447 PTHR43157:SF31 PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG184994|UniProtKB=T1FM88 T1FM88 20209937 PTHR13509:SF3 SEC61 SUBUNIT BETA PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT BETA nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 cotranslational protein targeting to membrane#GO:0006613;cellular localization#GO:0051641;intracellular protein transmembrane transport#GO:0065002;macromolecule localization#GO:0033036;post-translational protein targeting to membrane, translocation#GO:0031204;transport#GO:0006810;protein transmembrane transport#GO:0071806;nitrogen compound transport#GO:0071705;establishment of protein localization#GO:0045184;SRP-dependent cotranslational protein targeting to membrane#GO:0006614;organic substance transport#GO:0071702;establishment of protein localization to membrane#GO:0090150;post-translational protein targeting to endoplasmic reticulum membrane#GO:0006620;establishment of localization#GO:0051234;protein localization to organelle#GO:0033365;establishment of protein localization to endoplasmic reticulum#GO:0072599;localization within membrane#GO:0051668;protein localization to endoplasmic reticulum#GO:0070972;transmembrane transport#GO:0055085;protein localization to membrane#GO:0072657;protein targeting#GO:0006605;establishment of protein localization to organelle#GO:0072594;protein targeting to ER#GO:0045047;cellular process#GO:0009987;protein localization#GO:0008104;localization#GO:0051179;protein targeting to membrane#GO:0006612;cellular macromolecule localization#GO:0070727;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 cellular anatomical entity#GO:0110165;membrane#GO:0016020 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG99321|UniProtKB=T1G9S2 T1G9S2 20217818 PTHR11373:SF4 DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578 cellular aromatic compound metabolic process#GO:0006725;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative metabolic process#GO:1901135;heterocycle catabolic process#GO:0046700;organonitrogen compound catabolic process#GO:1901565;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;purine-containing compound catabolic process#GO:0072523;phosphate-containing compound metabolic process#GO:0006796;cellular nitrogen compound catabolic process#GO:0044270;organic cyclic compound metabolic process#GO:1901360;purine nucleotide catabolic process#GO:0006195;nitrogen compound metabolic process#GO:0006807;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;purine nucleotide metabolic process#GO:0006163;cellular catabolic process#GO:0044248;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;nucleoside phosphate catabolic process#GO:1901292;carbohydrate derivative catabolic process#GO:1901136;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;nucleotide catabolic process#GO:0009166;nucleoside triphosphate catabolic process#GO:0009143;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;organophosphate catabolic process#GO:0046434;primary metabolic process#GO:0044238;aromatic compound catabolic process#GO:0019439;organic cyclic compound catabolic process#GO:1901361;organophosphate metabolic process#GO:0019637;purine nucleoside triphosphate metabolic process#GO:0009144;nucleobase-containing compound catabolic process#GO:0034655;nucleotide metabolic process#GO:0009117;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG71342|UniProtKB=T1G0J9 T1G0J9 20214597 PTHR22809:SF5 METHYLTRANSFERASE-RELATED TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL6 methyltransferase#PC00155 HELRO|EnsemblGenome=HelroG190041|UniProtKB=T1FRM3 T1FRM3 20211470 PTHR13155:SF1 A-KINASE ANCHOR PROTEINS A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG174842|UniProtKB=T1F8J2 T1F8J2 20205141 PTHR31395:SF23 SHISA GEO05642P1 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG179340|UniProtKB=T1FEK6 T1FEK6 20207255 PTHR24211:SF20 LIM DOMAIN-CONTAINING PROTEIN PROTEIN ESPINAS-RELATED scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG161868|UniProtKB=T1ERZ4 T1ERZ4 20199344 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG189672|UniProtKB=T1FR89 T1FR89 20211336 PTHR13451:SF0 CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81 CROSSOVER JUNCTION ENDONUCLEASE MUS81 hydrolase activity, acting on ester bonds#GO:0016788;DNA endonuclease activity#GO:0004520;nuclease activity#GO:0004518;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787;endonuclease activity#GO:0004519;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097 DNA repair#GO:0006281;DNA damage checkpoint signaling#GO:0000077;mitotic cell cycle checkpoint signaling#GO:0007093;nuclear division#GO:0000280;nucleobase-containing compound metabolic process#GO:0006139;regulation of biological process#GO:0050789;cell cycle checkpoint signaling#GO:0000075;DNA damage response#GO:0006974;mitotic cell cycle#GO:0000278;nitrogen compound metabolic process#GO:0006807;recombinational repair#GO:0000725;meiosis I cell cycle process#GO:0061982;reproductive process#GO:0022414;intracellular signal transduction#GO:0035556;meiosis I#GO:0007127;organic substance metabolic process#GO:0071704;negative regulation of cell cycle#GO:0045786;macromolecule metabolic process#GO:0043170;meiotic cell cycle#GO:0051321;regulation of cell cycle phase transition#GO:1901987;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cell communication#GO:0007154;cellular nitrogen compound metabolic process#GO:0034641;double-strand break repair via homologous recombination#GO:0000724;DNA recombination#GO:0006310;primary metabolic process#GO:0044238;regulation of cell cycle process#GO:0010564;resolution of meiotic recombination intermediates#GO:0000712;cellular component organization or biogenesis#GO:0071840;response to stress#GO:0006950;reproduction#GO:0000003;regulation of cellular process#GO:0050794;sexual reproduction#GO:0019953;cellular response to stress#GO:0033554;cellular aromatic compound metabolic process#GO:0006725;signal transduction#GO:0007165;negative regulation of biological process#GO:0048519;double-strand break repair#GO:0006302;mitotic intra-S DNA damage checkpoint signaling#GO:0031573;cell cycle process#GO:0022402;negative regulation of cell cycle process#GO:0010948;mitotic cell cycle process#GO:1903047;reciprocal homologous recombination#GO:0140527;organic cyclic compound metabolic process#GO:1901360;meiotic cell cycle process#GO:1903046;signal transduction in response to DNA damage#GO:0042770;reciprocal meiotic recombination#GO:0007131;signaling#GO:0023052;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of mitotic cell cycle#GO:0045930;cellular process#GO:0009987;DNA integrity checkpoint signaling#GO:0031570;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;double-strand break repair via break-induced replication#GO:0000727;organelle organization#GO:0006996;meiotic nuclear division#GO:0140013;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;organelle fission#GO:0048285;mitotic DNA integrity checkpoint signaling#GO:0044774;homologous recombination#GO:0035825;mitotic DNA damage checkpoint signaling#GO:0044773;regulation of mitotic cell cycle#GO:0007346;DNA metabolic process#GO:0006259 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;endonuclease complex#GO:1905348;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG76282|UniProtKB=T1G2H8 T1G2H8 20215276 PTHR24637:SF377 COLLAGEN COLLAGEN TYPE IX ALPHA 1 CHAIN HELRO|EnsemblGenome=HelroG177390|UniProtKB=T1FBL7 T1FBL7 20206216 PTHR14445:SF52 GRB10 INTERACTING GYF PROTEIN SUBFAMILY NOT NAMED cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG107639|UniProtKB=T1EEB8 T1EEB8 20194920 PTHR21581:SF6 D-ALANYL-D-ALANINE CARBOXYPEPTIDASE TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 12 serine protease#PC00203 HELRO|EnsemblGenome=HelroG187875|UniProtKB=T1FPF9 T1FPF9 20210706 PTHR46345:SF8 INVERTED FORMIN-2 FORMIN 3, ISOFORM B HELRO|EnsemblGenome=HelroG158928|UniProtKB=T1ENF1 T1ENF1 20198101 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170384|UniProtKB=T1F2Z5 T1F2Z5 20203194 PTHR46641:SF25 FMRFAMIDE RECEPTOR-RELATED CNMAMIDE RECEPTOR-RELATED transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG188139|UniProtKB=T1FPP3 T1FPP3 20210790 PTHR11256:SF47 BCL-2 RELATED BCL-2-LIKE PROTEIN 10 protein binding#GO:0005515;binding#GO:0005488 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of cysteine-type endopeptidase activity involved in apoptotic process#GO:0043280;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;signal transduction#GO:0007165;positive regulation of cysteine-type endopeptidase activity#GO:2001056;regulation of protein metabolic process#GO:0051246;apoptotic mitochondrial changes#GO:0008637;regulation of cysteine-type endopeptidase activity#GO:2000116;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;positive regulation of proteolysis#GO:0045862;regulation of biological process#GO:0050789;activation of cysteine-type endopeptidase activity involved in apoptotic process#GO:0006919;DNA damage response#GO:0006974;positive regulation of metabolic process#GO:0009893;regulation of molecular function#GO:0065009;apoptotic process#GO:0006915;cell death#GO:0008219;regulation of hydrolase activity#GO:0051336;mitochondrion organization#GO:0007005;intracellular signal transduction#GO:0035556;positive regulation of biological process#GO:0048518;positive regulation of peptidase activity#GO:0010952;signaling#GO:0023052;regulation of proteolysis#GO:0030162;cellular response to stimulus#GO:0051716;positive regulation of catalytic activity#GO:0043085;programmed cell death#GO:0012501;cell communication#GO:0007154;cellular component organization#GO:0016043;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of hydrolase activity#GO:0051345;regulation of primary metabolic process#GO:0080090;cellular component organization or biogenesis#GO:0071840;intrinsic apoptotic signaling pathway#GO:0097193;apoptotic signaling pathway#GO:0097190;response to stimulus#GO:0050896;positive regulation of protein metabolic process#GO:0051247;response to stress#GO:0006950;extrinsic apoptotic signaling pathway#GO:0097191;regulation of macromolecule metabolic process#GO:0060255;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;regulation of endopeptidase activity#GO:0052548;regulation of cysteine-type endopeptidase activity involved in apoptotic process#GO:0043281;regulation of peptidase activity#GO:0052547;release of cytochrome c from mitochondria#GO:0001836;cellular response to stress#GO:0033554;positive regulation of endopeptidase activity#GO:0010950;regulation of metabolic process#GO:0019222 bounding membrane of organelle#GO:0098588;envelope#GO:0031975;mitochondrial membrane#GO:0031966;mitochondrial outer membrane#GO:0005741;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867 Apoptosis signaling pathway#P00006>Diva#P00285 HELRO|EnsemblGenome=HelroG190060|UniProtKB=T1FRM9 T1FRM9 20211476 PTHR39063:SF1 ORAL-FACIAL-DIGITAL SYNDROME 1 PROTEIN HOMOLOG OFD1 CENTRIOLE AND CENTRIOLAR SATELLITE PROTEIN left/right pattern formation#GO:0060972;multicellular organism development#GO:0007275;transport#GO:0006810;regionalization#GO:0003002;developmental process#GO:0032502;microtubule-based movement#GO:0007018;cellular process#GO:0009987;cilium movement#GO:0003341;localization#GO:0051179;epithelial cilium movement involved in extracellular fluid movement#GO:0003351;microtubule-based transport#GO:0099111;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;anatomical structure development#GO:0048856;multicellular organismal process#GO:0032501;determination of left/right symmetry#GO:0007368;pattern specification process#GO:0007389 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule organizing center#GO:0005815;microtubule cytoskeleton#GO:0015630;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;cell projection#GO:0042995;cellular anatomical entity#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cilium#GO:0005929;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG106488|UniProtKB=T1EE29 T1EE29 20194831 PTHR45679:SF5 ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2 ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1 HELRO|EnsemblGenome=HelroG167146|UniProtKB=T1EZ27 T1EZ27 20201827 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;peptide-lysine-N-acetyltransferase activity#GO:0061733;peptide N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-acyltransferase activity#GO:0016410 HELRO|EnsemblGenome=HelroG174382|UniProtKB=T1F823 T1F823 20204972 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG190772|UniProtKB=T1FSA2 T1FSA2 20211699 PTHR24253:SF185 TRANSMEMBRANE PROTEASE SERINE PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN serine protease#PC00203;protease#PC00190 HELRO|EnsemblGenome=HelroG100728|UniProtKB=T1ED15 T1ED15 20194467 PTHR10102:SF0 DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL catalytic activity, acting on RNA#GO:0140098;5'-3' RNA polymerase activity#GO:0034062;transferase activity#GO:0016740;DNA-directed 5'-3' RNA polymerase activity#GO:0003899;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;RNA polymerase activity#GO:0097747;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;heterocycle metabolic process#GO:0046483;mitochondrial RNA metabolic process#GO:0000959;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;mitochondrial gene expression#GO:0140053;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;mitochondrial transcription#GO:0006390;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nucleobase-containing compound biosynthetic process#GO:0034654;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;aromatic compound biosynthetic process#GO:0019438;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;catalytic complex#GO:1902494;transferase complex#GO:1990234;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;membrane-bounded organelle#GO:0043227;mitochondrial protein-containing complex#GO:0098798 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG194445|UniProtKB=T1FW23 T1FW23 20213019 PTHR42996:SF1 PHOSPHATE-BINDING PROTEIN PSTS PHOSPHATE-BINDING PROTEIN PSTS ATP-binding cassette (ABC) transporter#PC00003;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG165883|UniProtKB=T1EXE5 T1EXE5 20201245 PTHR21207:SF2 PARKIN COREGULATED GENE PROTEIN PARK2 COREGULATED PARKIN COREGULATED GENE PROTEIN heat shock protein binding#GO:0031072;protein binding#GO:0005515;protein-folding chaperone binding#GO:0051087;binding#GO:0005488;Hsp70 protein binding#GO:0030544;Hsp90 protein binding#GO:0051879 HELRO|EnsemblGenome=HelroG159622|UniProtKB=T1EP91 T1EP91 20198391 PTHR13136:SF16 TESTIS DEVELOPMENT PROTEIN PRTD KAT8 REGULATORY NSL COMPLEX SUBUNIT 3 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 histone acetyltransferase complex#GO:0000123;acetyltransferase complex#GO:1902493;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein acetyltransferase complex#GO:0031248;protein-containing complex#GO:0032991;chromosome#GO:0005694 HELRO|EnsemblGenome=HelroG86102|UniProtKB=T1G673 T1G673 20216570 PTHR10739:SF13 CYTIDYLYLTRANSFERASE CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE cation binding#GO:0043169;transferase activity#GO:0016740;phosphatidylcholine binding#GO:0031210;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772;lipid binding#GO:0008289;ion binding#GO:0043167;phospholipid binding#GO:0005543 transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG179960|UniProtKB=T1FFA5 T1FFA5 20207504 PTHR45713:SF6 FTP DOMAIN-CONTAINING PROTEIN F5_8 TYPE C DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162380|UniProtKB=T1ESL0 T1ESL0 20199560 PTHR10725:SF74 THAP DOMAIN-CONTAINING PROTEIN 9 ERAP1-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG169548|UniProtKB=T1F230 T1F230 20202880 PTHR10117:SF54 TRANSIENT RECEPTOR POTENTIAL CHANNEL TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;calcium channel activity#GO:0005262;small molecule binding#GO:0036094;binding#GO:0005488;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;anion binding#GO:0043168;ion binding#GO:0043167;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;alcohol binding#GO:0043178 inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;calcium ion transmembrane transport#GO:0070588;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;regulation of cytosolic calcium ion concentration#GO:0051480;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;calcium ion transport#GO:0006816;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;cation channel complex#GO:0034703;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 Alzheimer disease-presenilin pathway#P00004>Capacitative calcium channels#P00124 HELRO|EnsemblGenome=HelroG65557|UniProtKB=T1FY96 T1FY96 20213794 PTHR45956:SF6 RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN RUN DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170089|UniProtKB=T1F2M0 T1F2M0 20203069 PTHR12233:SF1 VACUOLAR PROTEIN SORTING 26 RELATED VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 26 endosomal transport#GO:0016197;cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;cytosolic transport#GO:0016482;establishment of protein localization#GO:0045184;retrograde transport, endosome to Golgi#GO:0042147;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 cytoplasm#GO:0005737;membrane protein complex#GO:0098796;endosome#GO:0005768;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG125565|UniProtKB=T1EH66 T1EH66 20195916 PTHR10270:SF161 SOX TRANSCRIPTION FACTOR SEX-DETERMINING REGION Y PROTEIN DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of RNA biosynthetic process#GO:2001141;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;cell differentiation#GO:0030154;positive regulation of metabolic process#GO:0009893;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;positive regulation of cellular biosynthetic process#GO:0031328;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;positive regulation of RNA metabolic process#GO:0051254;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;HMG box transcription factor#PC00024 HELRO|EnsemblGenome=HelroG78053|UniProtKB=T1G372 T1G372 20215520 PTHR12936:SF0 ANAPHASE-PROMOTING COMPLEX 10 ANAPHASE-PROMOTING COMPLEX SUBUNIT 10 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;post-translational protein modification#GO:0043687;protein K11-linked ubiquitination#GO:0070979;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234;anaphase-promoting complex#GO:0005680;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Cell cycle#P00013>APC#P00481 HELRO|EnsemblGenome=HelroG73487|UniProtKB=T1G1E3 T1G1E3 20214891 PTHR14453:SF67 PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN POLY [ADP-RIBOSE] POLYMERASE molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;protein-macromolecule adaptor activity#GO:0030674 negative regulation of gene expression#GO:0010629;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG91552|UniProtKB=T1G853 T1G853 20217250 PTHR19858:SF0 WD40 REPEAT PROTEIN PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;ncRNA metabolic process#GO:0034660;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;ribosome biogenesis#GO:0042254;non-membrane-bounded organelle assembly#GO:0140694;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;protein-RNA complex organization#GO:0071826;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274 membrane-enclosed lumen#GO:0031974;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981;90S preribosome#GO:0030686;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG112372|UniProtKB=T1EFJ1 T1EFJ1 20195343 PTHR12375:SF47 RNA-BINDING PROTEIN LUC7-RELATED LUC7-LIKE PROTEIN 3 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;mRNA splice site recognition#GO:0006376;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375;spliceosomal complex assembly#GO:0000245 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;U1 snRNP#GO:0005685;U2-type spliceosomal complex#GO:0005684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;spliceosomal snRNP complex#GO:0097525;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;U2-type prespliceosome#GO:0071004;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG89568|UniProtKB=T1G7E3 T1G7E3 20216990 PTHR45725:SF1 FORMIN HOMOLOGY 2 FAMILY MEMBER DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HELRO|EnsemblGenome=HelroG162356|UniProtKB=T1ESJ8 T1ESJ8 20199548 PTHR23077:SF9 AAA-FAMILY ATPASE PEROXISOMAL ATPASE PEX6 pyrophosphatase activity#GO:0016462;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ATP hydrolysis activity#GO:0016887;ribonucleoside triphosphate phosphatase activity#GO:0017111 cellular localization#GO:0051641;intracellular protein transmembrane transport#GO:0065002;transmembrane transport#GO:0055085;macromolecule localization#GO:0033036;protein import into peroxisome matrix#GO:0016558;transport#GO:0006810;protein transmembrane transport#GO:0071806;nitrogen compound transport#GO:0071705;establishment of protein localization to organelle#GO:0072594;cellular component organization#GO:0016043;cellular process#GO:0009987;protein transmembrane import into intracellular organelle#GO:0044743;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;organelle organization#GO:0006996;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365;peroxisome organization#GO:0007031 bounding membrane of organelle#GO:0098588;peroxisomal membrane#GO:0005778;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;peroxisome#GO:0005777;microbody#GO:0042579;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG173620|UniProtKB=T1F722 T1F722 20204621 PTHR46582:SF1 ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 18 ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 18 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;precatalytic spliceosome#GO:0071011;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG100710|UniProtKB=T1ED14 T1ED14 20194466 PTHR11246:SF5 PRE-MRNA SPLICING FACTOR PRE-MRNA-SPLICING FACTOR SYF1 cellular aromatic compound metabolic process#GO:0006725;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-RNA complex assembly#GO:0022618;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;organic substance metabolic process#GO:0071704;mRNA splicing, via spliceosome#GO:0000398;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;ribonucleoprotein complex biogenesis#GO:0022613;mRNA processing#GO:0006397;protein-RNA complex organization#GO:0071826;RNA splicing, via transesterification reactions#GO:0000375 catalytic step 2 spliceosome#GO:0071013;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;U2-type spliceosomal complex#GO:0005684;cellular anatomical entity#GO:0110165;organelle#GO:0043226;post-mRNA release spliceosomal complex#GO:0071014;spliceosomal complex#GO:0005681;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;Prp19 complex#GO:0000974;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG66868|UniProtKB=T1FYS1 T1FYS1 20213969 PTHR46273:SF4 MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED AT19640P signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG181653|UniProtKB=T1FH73 T1FH73 20208172 PTHR24247:SF202 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE RECEPTOR 1 signaling receptor activity#GO:0038023;G protein-coupled amine receptor activity#GO:0008227;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;chemical synaptic transmission#GO:0007268;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;synaptic signaling#GO:0099536;trans-synaptic signaling#GO:0099537;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;cell-cell signaling#GO:0007267;signaling#GO:0023052 somatodendritic compartment#GO:0036477;neuron projection#GO:0043005;dendrite#GO:0030425;cell periphery#GO:0071944;dendritic tree#GO:0097447;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720 HELRO|EnsemblGenome=HelroG160694|UniProtKB=T1EQM0 T1EQM0 20198870 PTHR15414:SF5 OS-9-RELATED PROTEIN OS-9 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;protein catabolic process#GO:0030163;nitrogen compound transport#GO:0071705;organonitrogen compound catabolic process#GO:1901565;establishment of protein localization#GO:0045184;organic substance transport#GO:0071702;establishment of localization#GO:0051234;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;proteasomal protein catabolic process#GO:0010498;protein metabolic process#GO:0019538;proteolysis involved in protein catabolic process#GO:0051603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;response to organic substance#GO:0010033;macromolecule catabolic process#GO:0009057;cellular response to stimulus#GO:0051716;response to endoplasmic reticulum stress#GO:0034976;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;ERAD pathway#GO:0036503;response to organonitrogen compound#GO:0010243;cellular process#GO:0009987;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;response to nitrogen compound#GO:1901698;response to stimulus#GO:0050896;response to stress#GO:0006950;cellular macromolecule localization#GO:0070727;response to chemical#GO:0042221;protein transport#GO:0015031;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular response to stress#GO:0033554 membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;endoplasmic reticulum lumen#GO:0005788;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG135186|UniProtKB=T1EI72 T1EI72 20196272 PTHR12775:SF0 PROTEIN C20ORF43 HOMOLOG REPLICATION TERMINATION FACTOR 2 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;DNA-templated DNA replication#GO:0006261;DNA replication#GO:0006260;organic substance metabolic process#GO:0071704;DNA metabolic process#GO:0006259;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG182052|UniProtKB=T1FHN6 T1FHN6 20208335 PTHR19282:SF516 TETRASPANIN TETRASPANIN cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG182367|UniProtKB=T1FI40 T1FI40 20208489 PTHR37862:SF1 FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 20 FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 20 HELRO|EnsemblGenome=HelroG165387|UniProtKB=T1EWP7 T1EWP7 20200997 PTHR47510:SF3 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG93617|UniProtKB=T1G8X0 T1G8X0 20217517 PTHR10288:SF340 KH DOMAIN CONTAINING RNA BINDING PROTEIN HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG87124|UniProtKB=T1G6M0 T1G6M0 20216717 PTHR10529:SF340 AP COMPLEX SUBUNIT MU CARMINE, ISOFORM A localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;import into cell#GO:0098657;transport#GO:0006810;endocytosis#GO:0006897 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HELRO|EnsemblGenome=HelroG79008|UniProtKB=T1G3I3 T1G3I3 20215631 PTHR48012:SF2 STERILE20-LIKE KINASE, ISOFORM B-RELATED STERILE20-LIKE KINASE, ISOFORM B transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;phosphorylation#GO:0016310;protein phosphorylation#GO:0006468;cellular process#GO:0009987;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG168556|UniProtKB=T1F0Q3 T1F0Q3 20202403 PTHR24117:SF9 AGAP007537-PB BCL-6 COREPRESSOR PCGF1 BINDING DOMAIN-CONTAINING PROTEIN molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;protein-macromolecule adaptor activity#GO:0030674 negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of RNA metabolic process#GO:0051253;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of RNA biosynthetic process#GO:1902679;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of DNA-templated transcription#GO:0045892;regulation of gene expression#GO:0010468;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG181812|UniProtKB=T1FHD1 T1FHD1 20208230 PTHR45818:SF3 PROTEIN VAV PROTEIN VAV nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336;regulation of catalytic activity#GO:0050790;regulation of GTPase activity#GO:0043087;regulation of molecular function#GO:0065009 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 PDGF signaling pathway#P00047>Vav#P01169 HELRO|EnsemblGenome=HelroG186995|UniProtKB=T1FP52 T1FP52 20210599 PTHR11524:SF16 60S RIBOSOMAL PROTEIN L7 LARGE RIBOSOMAL SUBUNIT PROTEIN UL30 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;RNA processing#GO:0006396;gene expression#GO:0010467;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of LSU-rRNA#GO:0000470;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;cytosolic ribosome#GO:0022626;protein-containing complex#GO:0032991;cytosolic large ribosomal subunit#GO:0022625;large ribosomal subunit#GO:0015934;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;intracellular organelle#GO:0043229;ribosomal subunit#GO:0044391;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG82362|UniProtKB=T1G4R1 T1G4R1 20216059 PTHR24208:SF105 LIM/HOMEOBOX PROTEIN LHX DLIM1 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;neurogenesis#GO:0022008;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;system development#GO:0048731;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;regulation of macromolecule biosynthetic process#GO:0010556;generation of neurons#GO:0048699;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG193526|UniProtKB=T1FV30 T1FV30 20212676 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG183411|UniProtKB=T1FJL3 T1FJL3 20209012 PTHR23275:SF100 CABRIOLET.-RELATED EGF-LIKE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG91402|UniProtKB=T1G832 T1G832 20217229 PTHR23423:SF17 ORGANIC SOLUTE TRANSPORTER-RELATED IP17403P localization#GO:0051179;establishment of localization#GO:0051234;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG173092|UniProtKB=T1F6C0 T1F6C0 20204369 PTHR46409:SF1 HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG87564|UniProtKB=T1G6S3 T1G6S3 20216770 PTHR21266:SF32 IRON-SULFUR DOMAIN CONTAINING PROTEIN CHOLESTEROL 7-DESATURASE NVD oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG176718|UniProtKB=T1FAT7 T1FAT7 20205936 PTHR34306:SF3 RAD60-SLD DOMAIN-CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN DDB_G0278469-RELATED HELRO|EnsemblGenome=HelroG68663|UniProtKB=T1FZH8 T1FZH8 20214226 PTHR43788:SF16 DNA2/NAM7 HELICASE FAMILY MEMBER HELICASE WITH ZINC FINGER 2 catalytic activity, acting on a nucleic acid#GO:0140640;ATP-dependent activity, acting on DNA#GO:0008094;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG187654|UniProtKB=T1FPB5 T1FPB5 20210662 PTHR10724:SF10 30S RIBOSOMAL PROTEIN S1 S1 RNA-BINDING DOMAIN-CONTAINING PROTEIN 1 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;translation#GO:0006412;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG189800|UniProtKB=T1FRD5 T1FRD5 20211382 PTHR24113:SF12 RAN GTPASE-ACTIVATING PROTEIN 1 RAN GTPASE-ACTIVATING PROTEIN 1 nucleoside-triphosphatase regulator activity#GO:0060589;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;binding#GO:0005488;molecular function regulator activity#GO:0098772;enzyme binding#GO:0019899;protein binding#GO:0005515;enzyme activator activity#GO:0008047;small GTPase binding#GO:0031267;enzyme regulator activity#GO:0030234 cellular localization#GO:0051641;regulation of GTPase activity#GO:0043087;positive regulation of catalytic activity#GO:0043085;positive regulation of GTPase activity#GO:0043547;transport#GO:0006810;activation of GTPase activity#GO:0090630;positive regulation of molecular function#GO:0044093;regulation of catalytic activity#GO:0050790;cellular process#GO:0009987;positive regulation of hydrolase activity#GO:0051345;localization#GO:0051179;establishment of localization#GO:0051234;nucleocytoplasmic transport#GO:0006913;regulation of molecular function#GO:0065009;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;regulation of hydrolase activity#GO:0051336;intracellular transport#GO:0046907;nuclear transport#GO:0051169 cytoplasm#GO:0005737;perinuclear region of cytoplasm#GO:0048471;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG177109|UniProtKB=T1FB85 T1FB85 20206084 PTHR23227:SF83 BUCENTAUR RELATED ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG170399|UniProtKB=T1F304 T1F304 20203203 PTHR13989:SF16 REPLICATION PROTEIN A-RELATED REPLICATION PROTEIN A2 DNA replication#P00017>RPA#P00537 HELRO|EnsemblGenome=HelroG87358|UniProtKB=T1G6P3 T1G6P3 20216740 PTHR10202:SF13 PRESENILIN PRESENILIN HOMOLOG hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 membrane protein proteolysis#GO:0033619;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;membrane protein ectodomain proteolysis#GO:0006509;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 aspartic protease#PC00053;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Presenilin N-terminal fragment#P00140;Notch signaling pathway#P00045>Presenilin#P01110;Alzheimer disease-amyloid secretase pathway#P00003>Presenilin N-terminal fragment#P00088;Alzheimer disease-amyloid secretase pathway#P00003>Presenilin C-terminal fragment#P00102;Alzheimer disease-presenilin pathway#P00004>Presenilin C-terminal fragment#P00155;Alzheimer disease-presenilin pathway#P00004>Presenilin#P00129;Alzheimer disease-amyloid secretase pathway#P00003>Presenilin#P00098 HELRO|EnsemblGenome=HelroG186760|UniProtKB=T1FP31 T1FP31 20210578 PTHR48105:SF19 THIOREDOXIN REDUCTASE 1-RELATED-RELATED THIOREDOXIN-DISULFIDE REDUCTASE protein-disulfide reductase activity#GO:0015035;disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;antioxidant activity#GO:0016209;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 homeostatic process#GO:0042592;cellular homeostasis#GO:0019725 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 reductase#PC00198;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG83340|UniProtKB=T1G545 T1G545 20216193 PTHR34524:SF6 CALCYPHOSIN CALCYPHOSINE LIKE calmodulin-related#PC00061 HELRO|EnsemblGenome=HelroG190840|UniProtKB=T1FSC9 T1FSC9 20211726 PTHR24092:SF175 PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE PHOSPHOLIPID-TRANSPORTING ATPASE ATPase-coupled intramembrane lipid transporter activity#GO:0140326;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;lipid transporter activity#GO:0005319 organophosphate ester transport#GO:0015748;macromolecule localization#GO:0033036;membrane organization#GO:0061024;transport#GO:0006810;cellular component organization#GO:0016043;regulation of membrane lipid distribution#GO:0097035;phospholipid transport#GO:0015914;cellular process#GO:0009987;lipid transport#GO:0006869;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organic substance transport#GO:0071702;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;biological regulation#GO:0065007;lipid translocation#GO:0034204;lipid localization#GO:0010876;phospholipid translocation#GO:0045332 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG194580|UniProtKB=T1FW78 T1FW78 20213074 PTHR24083:SF98 NUCLEAR HORMONE RECEPTOR NUCLEAR RECEPTOR SUBFAMILY 2 GROUP E MEMBER 1 cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;signaling receptor activity#GO:0038023;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG183155|UniProtKB=T1FJ81 T1FJ81 20208880 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG72374|UniProtKB=T1G0Z0 T1G0Z0 20214738 PTHR46392:SF1 DUAL SERINE/THREONINE AND TYROSINE PROTEIN KINASE DUAL SERINE_THREONINE AND TYROSINE PROTEIN KINASE regulation of MAPK cascade#GO:0043408;negative regulation of biological process#GO:0048519;response to growth factor#GO:0070848;positive regulation of signal transduction#GO:0009967;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of MAPK cascade#GO:0043410;regulation of biological process#GO:0050789;response to fibroblast growth factor#GO:0071774;positive regulation of response to stimulus#GO:0048584;response to endogenous stimulus#GO:0009719;negative regulation of programmed cell death#GO:0043069;regulation of signal transduction#GO:0009966;regulation of cellular response to growth factor stimulus#GO:0090287;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;negative regulation of cellular process#GO:0048523;regulation of programmed cell death#GO:0043067;regulation of cell communication#GO:0010646;cellular response to endogenous stimulus#GO:0071495;regulation of apoptotic process#GO:0042981;negative regulation of apoptotic process#GO:0043066;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;response to stimulus#GO:0050896;cellular response to growth factor stimulus#GO:0071363;regulation of cellular process#GO:0050794;regulation of ERK1 and ERK2 cascade#GO:0070372;positive regulation of cell communication#GO:0010647;biological regulation#GO:0065007;positive regulation of ERK1 and ERK2 cascade#GO:0070374;cellular response to fibroblast growth factor stimulus#GO:0044344 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG169282|UniProtKB=T1F1Q1 T1F1Q1 20202751 PTHR10201:SF291 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED hydrolase activity#GO:0016787;metalloendopeptidase activity#GO:0004222;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HELRO|EnsemblGenome=HelroG172104|UniProtKB=T1F512 T1F512 20203911 PTHR24390:SF233 ZINC FINGER PROTEIN C2H2-TYPE DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG182707|UniProtKB=T1FIM2 T1FIM2 20208671 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG155666|UniProtKB=T1ELK1 T1ELK1 20197451 PTHR24347:SF412 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE H1 HOMOLOG-RELATED non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CaMK#P00847;Ionotropic glutamate receptor pathway#P00037>CaMKII#P01023 HELRO|EnsemblGenome=HelroG192210|UniProtKB=T1FTP6 T1FTP6 20212193 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG162417|UniProtKB=T1ESM4 T1ESM4 20199574 PTHR23081:SF36 RNA POLYMERASE II CTD PHOSPHATASE RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578 protein phosphatase#PC00195;protein modifying enzyme#PC00260 General transcription regulation#P00023>TFIIF#P00665;Transcription regulation by bZIP transcription factor#P00055>TFIIF#P01394 HELRO|EnsemblGenome=HelroG161517|UniProtKB=T1ERL0 T1ERL0 20199210 PTHR20963:SF8 MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE 1 hydrolase#PC00121;phosphatase#PC00181 HELRO|EnsemblGenome=HelroG63527|UniProtKB=T1FXH0 T1FXH0 20213518 PTHR14005:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A nucleic acid binding#GO:0003676;RNA binding#GO:0003723;translation regulator activity#GO:0045182;binding#GO:0005488;organic cyclic compound binding#GO:0097159;translation initiation factor activity#GO:0003743;mRNA binding#GO:0003729;translation regulator activity, nucleic acid binding#GO:0090079;translation factor activity, RNA binding#GO:0008135 cellular component biogenesis#GO:0044085;peptide metabolic process#GO:0006518;protein-containing complex assembly#GO:0065003;gene expression#GO:0010467;biosynthetic process#GO:0009058;translation#GO:0006412;protein-RNA complex assembly#GO:0022618;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cytoplasmic translation#GO:0002181;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;cytoplasmic translational initiation#GO:0002183;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;primary metabolic process#GO:0044238;amide biosynthetic process#GO:0043604;cellular component organization or biogenesis#GO:0071840;peptide biosynthetic process#GO:0043043;protein-containing complex organization#GO:0043933;ribonucleoprotein complex biogenesis#GO:0022613;translational initiation#GO:0006413;protein-RNA complex organization#GO:0071826 cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;cellular anatomical entity#GO:0110165;protein-containing complex#GO:0032991;eukaryotic translation initiation factor 3 complex#GO:0005852;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG161341|UniProtKB=T1ERD1 T1ERD1 20199131 PTHR24073:SF285 DRAB5-RELATED RAS-RELATED PROTEIN RAB-18 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 localization#GO:0051179;organic substance transport#GO:0071702;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;protein transport#GO:0015031;nitrogen compound transport#GO:0071705;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG65843|UniProtKB=T1FYD4 T1FYD4 20213832 PTHR13163:SF0 SPINAL CORD EXPRESSION PROTEIN 4 NOVEL ACETYLCHOLINE RECEPTOR CHAPERONE cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;protein-containing complex assembly#GO:0065003;regulation of localization#GO:0032879;chaperone-mediated protein complex assembly#GO:0051131;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of cellular localization#GO:0060341;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of cellular process#GO:0050794;protein-containing complex organization#GO:0043933;biological regulation#GO:0065007;positive regulation of protein localization#GO:1903829;positive regulation of biological process#GO:0048518;regulation of protein localization#GO:0032880 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG192414|UniProtKB=T1FTX8 T1FTX8 20212275 PTHR23167:SF46 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED EPS15 HOMOLOGY DOMAIN CONTAINING PROTEIN-BINDING PROTEIN 1, ISOFORM F scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG177495|UniProtKB=T1FBS7 T1FBS7 20206276 PTHR45823:SF1 T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG110189|UniProtKB=T1EF03 T1EF03 20195155 PTHR43684:SF1 FAMILY NOT NAMED ENOYL-COA DELTA ISOMERASE 2 HELRO|EnsemblGenome=HelroG188104|UniProtKB=T1FPN0 T1FPN0 20210777 PTHR37431:SF3 PROTEIN CBG06927 DUF19 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG115400|UniProtKB=T1EG79 T1EG79 20195581 PTHR10672:SF3 ADDUCIN PROTEIN HU-LI TAI SHAO cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;cytoskeleton#GO:0005856;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG188142|UniProtKB=T1FPP6 T1FPP6 20210793 PTHR24543:SF334 MULTICOPPER OXIDASE-RELATED F5_8 TYPE C DOMAIN-CONTAINING PROTEIN oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG191158|UniProtKB=T1FSN8 T1FSN8 20211835 PTHR18952:SF265 CARBONIC ANHYDRASE CARBONIC ANHYDRASE dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG152141|UniProtKB=T1EKP6 T1EKP6 20197146 PTHR12357:SF89 YTH YT521-B HOMOLOGY DOMAIN-CONTAINING YTH DOMAIN-CONTAINING FAMILY PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 positive regulation of nitrogen compound metabolic process#GO:0051173;regulation of mRNA stability#GO:0043488;regulation of catabolic process#GO:0009894;regulation of mRNA catabolic process#GO:0061013;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;positive regulation of cellular catabolic process#GO:0031331;RNA destabilization#GO:0050779;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of biological process#GO:0048518;positive regulation of mRNA metabolic process#GO:1903313;regulation of RNA stability#GO:0043487;regulation of cellular catabolic process#GO:0031329;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;positive regulation of mRNA catabolic process#GO:0061014;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;positive regulation of catabolic process#GO:0009896;positive regulation of RNA metabolic process#GO:0051254;mRNA destabilization#GO:0061157;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;regulation of mRNA metabolic process#GO:1903311 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG78789|UniProtKB=T1G3F9 T1G3F9 20215607 PTHR21377:SF0 PROTEIN FAM210B, MITOCHONDRIAL PROTEIN FAM210B, MITOCHONDRIAL cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG134781|UniProtKB=T1EI58 T1EI58 20196258 PTHR24390:SF230 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 362 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HELRO|EnsemblGenome=HelroG106596|UniProtKB=T1EE36 T1EE36 20194838 PTHR10953:SF6 UBIQUITIN-ACTIVATING ENZYME E1 NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT ligase activity#GO:0016874;transferase activity#GO:0016740;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877;nucleotidyltransferase activity#GO:0016779;thiosulfate sulfurtransferase activity#GO:0004792;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity, acting on a protein#GO:0140096;sulfurtransferase activity#GO:0016783 protein neddylation#GO:0045116;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;nitrogen compound metabolic process#GO:0006807;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E1#P01492 HELRO|EnsemblGenome=HelroG161724|UniProtKB=T1ERU2 T1ERU2 20199292 PTHR35069:SF1 PROTEIN C9ORF135 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 95 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG193551|UniProtKB=T1FV43 T1FV43 20212689 PTHR10520:SF12 TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3 ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;biosynthetic process#GO:0009058;nucleobase metabolic process#GO:0009112;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;purine nucleobase metabolic process#GO:0006144;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 De novo purine biosynthesis#P02738>Phosphoribosylamine glycine ligase#P02908 HELRO|EnsemblGenome=HelroG171831|UniProtKB=T1F4R4 T1F4R4 20203813 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG88458|UniProtKB=T1G729 T1G729 20216876 PTHR13952:SF6 U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD U11_U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 35 KDA PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;snRNA binding#GO:0017069;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;precatalytic spliceosome#GO:0071011;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG70217|UniProtKB=T1G035 T1G035 20214433 PTHR45829:SF4 MITOCHONDRIAL CARRIER PROTEIN RIM2 MITOCHONDRIAL CARRIER PROTEIN RIM2 nucleobase-containing compound transmembrane transporter activity#GO:0015932;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 mitochondrial genome maintenance#GO:0000002;organophosphate ester transport#GO:0015748;transmembrane transport#GO:0055085;transport#GO:0006810;nitrogen compound transport#GO:0071705;cellular component organization#GO:0016043;cellular process#GO:0009987;mitochondrial transport#GO:0006839;localization#GO:0051179;organic substance transport#GO:0071702;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;organelle organization#GO:0006996;nucleobase-containing compound transport#GO:0015931;mitochondrion organization#GO:0007005;mitochondrial transmembrane transport#GO:1990542 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 mitochondrial carrier protein#PC00158;secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG157109|UniProtKB=T1EM62 T1EM62 20197662 PTHR10585:SF14 ER LUMEN PROTEIN RETAINING RECEPTOR ER LUMEN PROTEIN-RETAINING RECEPTOR signal sequence binding#GO:0005048;binding#GO:0005488;amide binding#GO:0033218;peptide binding#GO:0042277 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;protein localization to endoplasmic reticulum#GO:0070972;macromolecule localization#GO:0033036;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;protein localization#GO:0008104;localization#GO:0051179;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;maintenance of location#GO:0051235;maintenance of location in cell#GO:0051651;establishment of localization in cell#GO:0051649;protein localization to organelle#GO:0033365;intracellular transport#GO:0046907 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cis-Golgi network#GO:0005801;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG147374|UniProtKB=T1EJZ6 T1EJZ6 20196896 PTHR11849:SF289 ETS ETS-LIKE PROTEIN POINTED transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 PDGF signaling pathway#P00047>Ets#P01167 HELRO|EnsemblGenome=HelroG163106|UniProtKB=T1ETN6 T1ETN6 20199936 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG153284|UniProtKB=T1EL26 T1EL26 20197276 PTHR46289:SF14 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED DUF4371 DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157213|UniProtKB=T1EM82 T1EM82 20197682 PTHR23077:SF171 AAA-FAMILY ATPASE NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE pyrophosphatase activity#GO:0016462;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP hydrolysis activity#GO:0016887 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG185778|UniProtKB=T1FNA1 T1FNA1 20210298 PTHR24073:SF212 DRAB5-RELATED FI01544P GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824 localization#GO:0051179;organic substance transport#GO:0071702;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;transport#GO:0006810;protein transport#GO:0015031;nitrogen compound transport#GO:0071705;intracellular protein transport#GO:0006886;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104 cellular anatomical entity#GO:0110165;endomembrane system#GO:0012505 small GTPase#PC00208;G-protein#PC00020 HELRO|EnsemblGenome=HelroG167387|UniProtKB=T1EZC0 T1EZC0 20201920 PTHR16133:SF0 SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG185955|UniProtKB=T1FNH3 T1FNH3 20210370 PTHR10183:SF433 CALPAIN CALPAIN-A-RELATED cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197 macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;organonitrogen compound metabolic process#GO:1901564;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protease#PC00190 Huntington disease#P00029>Calpain#P00788 HELRO|EnsemblGenome=HelroG171296|UniProtKB=T1F417 T1F417 20203566 PTHR15698:SF10 PROTEIN CBG15099 PHYTANOYL-COA HYDROXYLASE-INTERACTING PROTEIN-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG179189|UniProtKB=T1FEB9 T1FEB9 20207168 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG114881|UniProtKB=T1EG52 T1EG52 20195554 PTHR24205:SF4 FOUR AND A HALF LIM DOMAINS PROTEIN PROTEIN ESPINAS molecular adaptor activity#GO:0060090;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;protein-macromolecule adaptor activity#GO:0030674 supramolecular complex#GO:0099080;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;Z disc#GO:0030018;cellular anatomical entity#GO:0110165;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;contractile fiber#GO:0043292;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;sarcomere#GO:0030017;membrane-bounded organelle#GO:0043227;myofibril#GO:0030016;I band#GO:0031674 transcription cofactor#PC00217 HELRO|EnsemblGenome=HelroG190259|UniProtKB=T1FRT8 T1FRT8 20211535 PTHR15744:SF0 BLOM7 KH HOMOLOGY DOMAIN-CONTAINING PROTEIN 4 nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG166191|UniProtKB=T1EXV9 T1EXV9 20201409 PTHR14739:SF9 MICROTUBULE-ASSOCIATED PROTEIN 9 MICROTUBULE-ASSOCIATED PROTEIN 9 cytoskeletal protein binding#GO:0008092;microtubule binding#GO:0008017;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 cellular component biogenesis#GO:0044085;mitotic spindle organization#GO:0007052;nuclear division#GO:0000280;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;microtubule cytoskeleton organization involved in mitosis#GO:1902850;regulation of cell division#GO:0051302;mitotic cell cycle process#GO:1903047;chromosome segregation#GO:0007059;regulation of biological process#GO:0050789;mitotic cell cycle#GO:0000278;mitotic spindle assembly#GO:0090307;spindle assembly#GO:0051225;mitotic nuclear division#GO:0140014;cytoskeleton organization#GO:0007010;mitotic sister chromatid segregation#GO:0000070;spindle organization#GO:0007051;non-membrane-bounded organelle assembly#GO:0140694;regulation of cytokinesis#GO:0032465;cellular component assembly#GO:0022607;nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of cell cycle process#GO:0010564;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;regulation of cellular process#GO:0050794;chromosome organization#GO:0051276;organelle organization#GO:0006996;biological regulation#GO:0065007;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;organelle fission#GO:0048285 supramolecular complex#GO:0099080;spindle microtubule#GO:0005876;cytoplasmic microtubule#GO:0005881;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cytoskeleton#GO:0005856;microtubule#GO:0005874;spindle#GO:0005819 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG86431|UniProtKB=T1G6C0 T1G6C0 20216617 PTHR23349:SF112 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST 48 RELATED 1, ISOFORM B sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of nitrogen compound metabolic process#GO:0051171;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG164792|UniProtKB=T1EVT4 T1EVT4 20200684 PTHR37445:SF3 PROTEIN CBG24663 ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG187806|UniProtKB=T1FPE1 T1FPE1 20210688 PTHR31804:SF2 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15 CUE DOMAIN-CONTAINING PROTEIN-RELATED HELRO|EnsemblGenome=HelroG182920|UniProtKB=T1FIX5 T1FIX5 20208774 PTHR11375:SF0 ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER A protein binding#GO:0005515;binding#GO:0005488;histone binding#GO:0042393 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HELRO|EnsemblGenome=HelroG177420|UniProtKB=T1FBN6 T1FBN6 20206235 PTHR15572:SF0 GLIOMA TUMOR SUPPRESSOR CANDIDATE REGION GENE 1 GLUTAMINE-RICH PROTEIN-RELATED positive regulation of nitrogen compound metabolic process#GO:0051173;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;positive regulation of cellular metabolic process#GO:0031325;regulation of RNA biosynthetic process#GO:2001141;positive regulation of cellular biosynthetic process#GO:0031328;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;positive regulation of nucleobase-containing compound metabolic process#GO:0045935;positive regulation of macromolecule biosynthetic process#GO:0010557;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;catalytic complex#GO:1902494;ATPase complex#GO:1904949;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;SWI/SNF complex#GO:0016514;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 HELRO|EnsemblGenome=HelroG190717|UniProtKB=T1FS83 T1FS83 20211680 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG85562|UniProtKB=T1G5Z3 T1G5Z3 20216490 PTHR14614:SF164 HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN HISTONE-ARGININE METHYLTRANSFERASE METTL23 protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG86957|UniProtKB=T1G6J9 T1G6J9 20216696 PTHR24340:SF35 HOMEOBOX PROTEIN NKX HGTX, ISOFORM C sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HELRO|EnsemblGenome=HelroG185933|UniProtKB=T1FNG3 T1FNG3 20210360 PTHR13691:SF73 RIBOSOMAL PROTEIN L2 LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;organic cyclic compound binding#GO:0097159 macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;mitochondrial gene expression#GO:0140053;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;gene expression#GO:0010467;mitochondrial translation#GO:0032543;cellular metabolic process#GO:0044237;cytoplasmic translation#GO:0002181;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;primary metabolic process#GO:0044238;translation#GO:0006412;amide biosynthetic process#GO:0043604;peptide biosynthetic process#GO:0043043;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrial large ribosomal subunit#GO:0005762;mitochondrion#GO:0005739;cellular anatomical entity#GO:0110165;organelle#GO:0043226;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;organellar ribosome#GO:0000313;protein-containing complex#GO:0032991;large ribosomal subunit#GO:0015934;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840;mitochondrial protein-containing complex#GO:0098798 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG176338|UniProtKB=T1FAE5 T1FAE5 20205794 PTHR46186:SF2 CYSTATIN CYSTATIN peptidase inhibitor activity#GO:0030414;molecular function regulator activity#GO:0098772;cysteine-type endopeptidase inhibitor activity#GO:0004869;peptidase regulator activity#GO:0061134;enzyme inhibitor activity#GO:0004857;endopeptidase regulator activity#GO:0061135;endopeptidase inhibitor activity#GO:0004866;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 regulation of proteolysis#GO:0030162;negative regulation of hydrolase activity#GO:0051346;negative regulation of biological process#GO:0048519;regulation of protein metabolic process#GO:0051246;regulation of cysteine-type endopeptidase activity#GO:2000116;regulation of nitrogen compound metabolic process#GO:0051171;negative regulation of cysteine-type endopeptidase activity#GO:2000117;negative regulation of peptidase activity#GO:0010466;negative regulation of endopeptidase activity#GO:0010951;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of proteolysis#GO:0045861;regulation of catalytic activity#GO:0050790;negative regulation of nitrogen compound metabolic process#GO:0051172;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of molecular function#GO:0065009;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;regulation of hydrolase activity#GO:0051336;regulation of endopeptidase activity#GO:0052548;regulation of peptidase activity#GO:0052547;negative regulation of catalytic activity#GO:0043086;regulation of metabolic process#GO:0019222;negative regulation of molecular function#GO:0044092 cytoplasm#GO:0005737;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622 protease inhibitor#PC00191 HELRO|EnsemblGenome=HelroG191153|UniProtKB=T1FSN6 T1FSN6 20211833 PTHR23423:SF17 ORGANIC SOLUTE TRANSPORTER-RELATED IP17403P localization#GO:0051179;establishment of localization#GO:0051234;transport#GO:0006810 cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG185503|UniProtKB=T1FMW6 T1FMW6 20210165 PTHR19139:SF199 AQUAPORIN TRANSPORTER MIP17260P cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transporter#PC00227 HELRO|EnsemblGenome=HelroG62260|UniProtKB=T1FWY0 T1FWY0 20213328 PTHR11453:SF36 ANION EXCHANGE PROTEIN ANION EXCHANGE PROTEIN secondary active transmembrane transporter activity#GO:0015291;inorganic molecular entity transmembrane transporter activity#GO:0015318;transmembrane transporter activity#GO:0022857;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;symporter activity#GO:0015293;active monoatomic ion transmembrane transporter activity#GO:0022853;solute:sodium symporter activity#GO:0015370;organic anion transmembrane transporter activity#GO:0008514;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;inorganic cation transmembrane transporter activity#GO:0022890;transporter activity#GO:0005215;solute:monoatomic cation symporter activity#GO:0015294 regulation of intracellular pH#GO:0051453;transmembrane transport#GO:0055085;organic anion transport#GO:0015711;transport#GO:0006810;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;regulation of pH#GO:0006885;organic substance transport#GO:0071702;regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;intracellular monoatomic cation homeostasis#GO:0030003;biological regulation#GO:0065007;intracellular monoatomic ion homeostasis#GO:0006873;regulation of cellular pH#GO:0030641 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG180354|UniProtKB=T1FFT2 T1FFT2 20207681 PTHR47510:SF3 REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG157327|UniProtKB=T1EM98 T1EM98 20197698 PTHR12838:SF0 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED membrane-enclosed lumen#GO:0031974;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG179315|UniProtKB=T1FEJ2 T1FEJ2 20207241 PTHR24261:SF7 PLASMINOGEN-RELATED KRINGLE DOMAIN-CONTAINING PROTEIN serine protease#PC00203;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG170504|UniProtKB=T1F351 T1F351 20203250 PTHR15549:SF6 PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR MID2 DOMAIN-CONTAINING PROTEIN immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG185003|UniProtKB=T1FM95 T1FM95 20209944 PTHR23415:SF29 CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7 CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT-RELATED protein kinase regulator activity#GO:0019887;molecular function activator activity#GO:0140677;binding#GO:0005488;molecular function regulator activity#GO:0098772;enzyme binding#GO:0019899;enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;histone binding#GO:0042393;kinase regulator activity#GO:0019207;kinase binding#GO:0019900;kinase activator activity#GO:0019209;protein kinase activator activity#GO:0030295;ubiquitin-like protein binding#GO:0032182;protein serine/threonine kinase activator activity#GO:0043539;ubiquitin binding#GO:0043130;protein binding#GO:0005515;protein kinase binding#GO:0019901 biological regulation#GO:0065007;regulation of biological process#GO:0050789;regulation of cell cycle#GO:0051726;regulation of mitotic cell cycle#GO:0007346;regulation of cellular process#GO:0050794 SCF ubiquitin ligase complex#GO:0019005;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;transferase complex, transferring phosphorus-containing groups#GO:0061695 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG159694|UniProtKB=T1EPB5 T1EPB5 20198415 PTHR13124:SF12 39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED LARGE RIBOSOMAL SUBUNIT PROTEIN ML46 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrial large ribosomal subunit#GO:0005762;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;ribosomal subunit#GO:0044391;intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;organellar ribosome#GO:0000313;protein-containing complex#GO:0032991;large ribosomal subunit#GO:0015934;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840;mitochondrial protein-containing complex#GO:0098798 ribosomal protein#PC00202;translational protein#PC00263 HELRO|EnsemblGenome=HelroG87913|UniProtKB=T1G6W8 T1G6W8 20216815 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG158018|UniProtKB=T1EMI8 T1EMI8 20197788 PTHR11528:SF34 HEAT SHOCK PROTEIN 90 FAMILY MEMBER HEAT SHOCK PROTEIN 83 protein binding#GO:0005515;unfolded protein binding#GO:0051082;binding#GO:0005488 cellular response to stimulus#GO:0051716;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;response to heat#GO:0009408;organonitrogen compound metabolic process#GO:1901564;protein maturation#GO:0051604;regulation of protein stability#GO:0031647;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;protein stabilization#GO:0050821;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;response to stress#GO:0006950;regulation of biological quality#GO:0065008;nitrogen compound metabolic process#GO:0006807;protein folding#GO:0006457;cellular response to heat#GO:0034605;biological regulation#GO:0065007;response to temperature stimulus#GO:0009266;response to abiotic stimulus#GO:0009628;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;perinuclear region of cytoplasm#GO:0048471;cytosol#GO:0005829;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 Hsp90 family chaperone#PC00028 HELRO|EnsemblGenome=HelroG146672|UniProtKB=T1EJT7 T1EJT7 20196837 PTHR11829:SF388 FORKHEAD BOX PROTEIN FORK HEAD DOMAIN-CONTAINING PROTEIN L1-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;cellular process#GO:0009987;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;cell differentiation#GO:0030154;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;anatomical structure morphogenesis#GO:0009653;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;anatomical structure development#GO:0048856;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HELRO|EnsemblGenome=HelroG131399|UniProtKB=T1EHV8 T1EHV8 20196158 PTHR10782:SF94 ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN SUPPRESSOR OF VARIEGATION 2-10, ISOFORM I molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;SUMO transferase activity#GO:0019789;protein-macromolecule adaptor activity#GO:0030674;ubiquitin-like protein ligase activity#GO:0061659;SUMO ligase activity#GO:0061665;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;regulation of DNA-templated transcription#GO:0006355;macromolecule metabolic process#GO:0043170;regulation of nitrogen compound metabolic process#GO:0051171;protein sumoylation#GO:0016925;regulation of transcription by RNA polymerase II#GO:0006357;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-amino acid modification#GO:0018193;regulation of RNA biosynthetic process#GO:2001141;post-translational protein modification#GO:0043687;regulation of RNA metabolic process#GO:0051252;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;nitrogen compound metabolic process#GO:0006807;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromatin#GO:0000785;protein-DNA complex#GO:0032993;chromosome#GO:0005694;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Interferon-gamma signaling pathway#P00035>PIAS#P00958 HELRO|EnsemblGenome=HelroG164735|UniProtKB=T1EVR5 T1EVR5 20200665 PTHR14063:SF1 PROTEIN LIN-7 HOMOLOG PDZ DOMAIN-CONTAINING PROTEIN 11 establishment or maintenance of cell polarity#GO:0007163;cellular localization#GO:0051641;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;macromolecule localization#GO:0033036;transport#GO:0006810;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;secretion#GO:0046903;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;signal release#GO:0023061;establishment or maintenance of apical/basal cell polarity#GO:0035088;cell-cell signaling#GO:0007267;signaling#GO:0023052;secretion by cell#GO:0032940;neurotransmitter secretion#GO:0007269;localization within membrane#GO:0051668;protein localization to membrane#GO:0072657;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;protein localization#GO:0008104;protein localization to cell periphery#GO:1990778;localization#GO:0051179;cellular macromolecule localization#GO:0070727;signal release from synapse#GO:0099643;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;establishment or maintenance of bipolar cell polarity#GO:0061245;export from cell#GO:0140352 basal plasma membrane#GO:0009925;synapse#GO:0045202;anchoring junction#GO:0070161;cell-cell junction#GO:0005911;basolateral plasma membrane#GO:0016323;cell junction#GO:0030054;plasma membrane region#GO:0098590;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;basal part of cell#GO:0045178;membrane#GO:0016020;plasma membrane#GO:0005886 cell junction protein#PC00070 HELRO|EnsemblGenome=HelroG84274|UniProtKB=T1G5G8 T1G5G8 20216315 PTHR22589:SF14 CARNITINE O-ACYLTRANSFERASE CHOLINE O-ACETYLTRANSFERASE transferase activity#GO:0016740;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acetyltransferase activity#GO:0016407;catalytic activity#GO:0003824;O-acyltransferase activity#GO:0008374 trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission#GO:0007268;nitrogen compound metabolic process#GO:0006807;synaptic signaling#GO:0099536;biological regulation#GO:0065007;neuromuscular synaptic transmission#GO:0007274;signaling#GO:0023052;cell-cell signaling#GO:0007267;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;neuron projection#GO:0043005;intracellular anatomical structure#GO:0005622 transferase#PC00220;acyltransferase#PC00042;metabolite interconversion enzyme#PC00262 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>CAT#P01076;Nicotinic acetylcholine receptor signaling pathway#P00044>CAT#P01087;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>CAT#P01063 HELRO|EnsemblGenome=HelroG66255|UniProtKB=T1FYI7 T1FYI7 20213885 PTHR10640:SF7 METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;sulfur compound metabolic process#GO:0006790;proteinogenic amino acid biosynthetic process#GO:0170038;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;aspartate family amino acid biosynthetic process#GO:0009067;alpha-amino acid biosynthetic process#GO:1901607;nitrogen compound metabolic process#GO:0006807;amino acid biosynthetic process#GO:0008652;alpha-amino acid metabolic process#GO:1901605;aspartate family amino acid metabolic process#GO:0009066;small molecule biosynthetic process#GO:0044283;L-amino acid biosynthetic process#GO:0170034;carboxylic acid metabolic process#GO:0019752;L-amino acid metabolic process#GO:0170033;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 dehydratase#PC00091;lyase#PC00144 HELRO|EnsemblGenome=HelroG114138|UniProtKB=T1EFZ5 T1EFZ5 20195497 PTHR10876:SF0 ZINC FINGER PROTEIN ZPR1 ZINC FINGER PROTEIN ZPR1 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG185747|UniProtKB=T1FN85 T1FN85 20210283 PTHR47979:SF38 DRAB11-RELATED GH01619P GTPase activity#GO:0003924;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;organic cyclic compound binding#GO:0097159;hydrolase activity#GO:0016787;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;anion binding#GO:0043168 localization#GO:0051179;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization#GO:0051234;transport#GO:0006810 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 small GTPase#PC00208 PDGF signaling pathway#P00047>Ras#P01154 HELRO|EnsemblGenome=HelroG108518|UniProtKB=T1EEJ7 T1EEJ7 20194999 PTHR46624:SF4 AGAP002036-PA FYVE-TYPE DOMAIN-CONTAINING PROTEIN phosphatidylinositol-3-phosphate binding#GO:0032266;small molecule binding#GO:0036094;binding#GO:0005488;lipid binding#GO:0008289;ion binding#GO:0043167;phosphatidylinositol binding#GO:0035091;anion binding#GO:0043168;phosphatidylinositol phosphate binding#GO:1901981;phospholipid binding#GO:0005543 localization#GO:0051179;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036;maintenance of location#GO:0051235;organelle organization#GO:0006996;cellular component organization#GO:0016043;lipid localization#GO:0010876;lipid storage#GO:0019915;cellular process#GO:0009987;non-membrane-bounded organelle assembly#GO:0140694 intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;lipid droplet#GO:0005811;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG72896|UniProtKB=T1G169 T1G169 20214817 PTHR19300:SF57 BETA-1,4-GALACTOSYLTRANSFERASE BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE galactosyltransferase activity#GO:0008378;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycosylation#GO:0070085;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG160724|UniProtKB=T1EQN1 T1EQN1 20198881 PTHR14166:SF17 SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN RHO-GAP DOMAIN-CONTAINING PROTEIN GTPase-activating protein#PC00257 PDGF signaling pathway#P00047>Rho#P01174 HELRO|EnsemblGenome=HelroG106966|UniProtKB=T1EE64 T1EE64 20194866 PTHR45703:SF36 DYNEIN HEAVY CHAIN DYNEIN HEAVY CHAIN, CYTOPLASMIC microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG187063|UniProtKB=T1FP66 T1FP66 20210613 PTHR13237:SF9 SOMETHING ABOUT SILENCING PROTEIN 10-RELATED NEUROGUIDIN cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;rRNA processing#GO:0006364;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;organic cyclic compound metabolic process#GO:1901360;ncRNA processing#GO:0034470;nitrogen compound metabolic process#GO:0006807;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;maturation of SSU-rRNA#GO:0030490;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;ribonucleoprotein complex#GO:1990904;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nuclear lumen#GO:0031981 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG183433|UniProtKB=T1FJN1 T1FJN1 20209030 PTHR15493:SF9 F-BOX ONLY PROTEIN 5 AND 43 GH14043P HELRO|EnsemblGenome=HelroG190569|UniProtKB=T1FS36 T1FS36 20211633 PTHR23353:SF23 RAB-GAP/TBC-RELATED PROTEIN HAIRLESS G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HELRO|EnsemblGenome=HelroG180295|UniProtKB=T1FFP6 T1FFP6 20207645 PTHR47763:SF1 ALPHA-PROTEIN KINASE VWKA DUF659 DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;protein serine/threonine kinase activity#GO:0004674;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;peptidyl-serine modification#GO:0018209;peptidyl-amino acid modification#GO:0018193;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG194337|UniProtKB=T1FVY2 T1FVY2 20212978 PTHR12751:SF18 PHOSPHATASE AND ACTIN REGULATOR PHACTR PHOSPHATASE AND ACTIN REGULATOR 1 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG170048|UniProtKB=T1F2K9 T1F2K9 20203058 PTHR12945:SF0 TRANSLATION INITIATION FACTOR EIF3-RELATED TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6 protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;membrane-bounded organelle#GO:0043227;methyltransferase complex#GO:0034708;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HELRO|EnsemblGenome=HelroG185187|UniProtKB=T1FMH5 T1FMH5 20210024 PTHR10589:SF17 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843 protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein modification by small protein removal#GO:0070646;protein deubiquitination#GO:0016579;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protease#PC00190 HELRO|EnsemblGenome=HelroG85425|UniProtKB=T1G5W9 T1G5W9 20216466 PTHR23503:SF8 SOLUTE CARRIER FAMILY 2 FACILITATED GLUCOSE TRANSPORTER PROTEIN 1 transmembrane transporter activity#GO:0022857;sugar transmembrane transporter activity#GO:0051119;transporter activity#GO:0005215;carbohydrate transmembrane transporter activity#GO:0015144 localization#GO:0051179;organic substance transport#GO:0071702;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;cellular process#GO:0009987;carbohydrate transmembrane transport#GO:0034219;carbohydrate transport#GO:0008643 cellular anatomical entity#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HELRO|EnsemblGenome=HelroG67040|UniProtKB=T1FYV6 T1FYV6 20214004 PTHR24235:SF12 NEUROPEPTIDE Y RECEPTOR G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG191383|UniProtKB=T1FSY1 T1FSY1 20211928 PTHR47163:SF2 DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN SI:DKEY-17M8.2 HELRO|EnsemblGenome=HelroG159992|UniProtKB=T1EPM7 T1EPM7 20198527 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED BRCT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG186286|UniProtKB=T1FNX2 T1FNX2 20210519 PTHR23389:SF3 CHROMOSOME TRANSMISSION FIDELITY FACTOR 18 CHROMOSOME TRANSMISSION FIDELITY PROTEIN 18 HOMOLOG nucleic acid binding#GO:0003676;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HELRO|EnsemblGenome=HelroG185559|UniProtKB=T1FMZ4 T1FMZ4 20210193 PTHR24067:SF157 UBIQUITIN-CONJUGATING ENZYME E2 FI11905P ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;modification-dependent protein catabolic process#GO:0019941;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;organonitrogen compound catabolic process#GO:1901565;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;modification-dependent macromolecule catabolic process#GO:0043632;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;proteolysis involved in protein catabolic process#GO:0051603;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG110971|UniProtKB=T1EF67 T1EF67 20195219 PTHR11785:SF528 AMINO ACID TRANSPORTER AMINO ACID TRANSPORTER PROTEIN JHI-21 L-amino acid transmembrane transporter activity#GO:0015179;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171;organic anion transmembrane transporter activity#GO:0008514;transporter activity#GO:0005215;organic acid transmembrane transporter activity#GO:0005342 localization#GO:0051179;organic substance transport#GO:0071702;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;amino acid transport#GO:0006865;organic anion transport#GO:0015711;organic acid transport#GO:0015849;transport#GO:0006810;nitrogen compound transport#GO:0071705;organic acid transmembrane transport#GO:1903825;carboxylic acid transport#GO:0046942;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039 transporter#PC00227 HELRO|EnsemblGenome=HelroG186024|UniProtKB=T1FNK1 T1FNK1 20210398 PTHR23359:SF70 NUCLEOTIDE KINASE ADENYLATE KINASE 1, ISOFORM B transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, phosphate group as acceptor#GO:0016776;catalytic activity#GO:0003824;kinase activity#GO:0016301 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 nucleotide kinase#PC00172;kinase#PC00137 De novo purine biosynthesis#P02738>Adenylate kinase#P02896 HELRO|EnsemblGenome=HelroG184849|UniProtKB=T1FM29 T1FM29 20209878 PTHR15907:SF161 DUF614 FAMILY PROTEIN-RELATED PLAC8 FAMILY PROTEIN HELRO|EnsemblGenome=HelroG86284|UniProtKB=T1G699 T1G699 20216596 PTHR23147:SF245 SERINE/ARGININE RICH SPLICING FACTOR CCHC-TYPE DOMAIN-CONTAINING PROTEIN nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;organic cyclic compound binding#GO:0097159 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981;cellular anatomical entity#GO:0110165;nuclear speck#GO:0016607;organelle#GO:0043226;nuclear body#GO:0016604;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG180234|UniProtKB=T1FFL5 T1FFL5 20207614 PTHR11690:SF248 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED PICKPOCKET 17, ISOFORM A monoatomic cation channel activity#GO:0005261;inorganic molecular entity transmembrane transporter activity#GO:0015318;sodium ion transmembrane transporter activity#GO:0015081;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;inorganic cation transmembrane transporter activity#GO:0022890;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834 localization#GO:0051179;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;monoatomic cation transport#GO:0006812;inorganic ion transmembrane transport#GO:0098660;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;sodium ion transmembrane transport#GO:0035725 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG78664|UniProtKB=T1G3E3 T1G3E3 20215591 PTHR23505:SF79 SPINSTER PROTEIN SPINSTER cellular anatomical entity#GO:0110165;membrane#GO:0016020 transporter#PC00227 HELRO|EnsemblGenome=HelroG94668|UniProtKB=T1G921 T1G921 20217568 PTHR48033:SF10 RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN RNA-BINDING PROTEIN SQUID nucleic acid binding#GO:0003676;RNA binding#GO:0003723;binding#GO:0005488;organic cyclic compound binding#GO:0097159 regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;chromatin#GO:0000785;protein-DNA complex#GO:0032993;nucleoplasm#GO:0005654;intracellular organelle lumen#GO:0070013;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;protein-containing complex#GO:0032991;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;nuclear lumen#GO:0031981 RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG194961|UniProtKB=T1FWL8 T1FWL8 20213213 PTHR24020:SF84 COLLAGEN ALPHA VWFA DOMAIN-CONTAINING PROTEIN extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HELRO|EnsemblGenome=HelroG135351|UniProtKB=T1EI81 T1EI81 20196281 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG175028|UniProtKB=T1F8Q9 T1F8Q9 20205208 PTHR46780:SF22 PROTEIN EVA-1 MIP32738P1 HELRO|EnsemblGenome=HelroG87041|UniProtKB=T1G6K8 T1G6K8 20216705 PTHR31488:SF3 DPY-19-LIKE 1, LIKE (H. SAPIENS) C-MANNOSYLTRANSFERASE DPY19L3 mannosyltransferase activity#GO:0000030;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule glycosylation#GO:0043413;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;protein glycosylation#GO:0006486;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;peptidyl-amino acid modification#GO:0018193;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nitrogen compound metabolic process#GO:0006807;protein metabolic process#GO:0019538;protein mannosylation#GO:0035268;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704;glycosylation#GO:0070085;mannosylation#GO:0097502 envelope#GO:0031975;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;organelle membrane#GO:0031090;organelle inner membrane#GO:0019866;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;nuclear membrane#GO:0031965;endomembrane system#GO:0012505;nuclear inner membrane#GO:0005637;membrane-bounded organelle#GO:0043227 HELRO|EnsemblGenome=HelroG140157|UniProtKB=T1EJ01 T1EJ01 20196551 PTHR24028:SF146 CADHERIN-87A CADHERIN 96CB, ISOFORM D-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 HELRO|EnsemblGenome=HelroG191177|UniProtKB=T1FSP7 T1FSP7 20211844 PTHR10316:SF40 MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED LD27118P regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;signaling#GO:0023052 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG164756|UniProtKB=T1EVS0 T1EVS0 20200670 PTHR45632:SF3 LD33804P KELCH-LIKE PROTEIN 32 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG191939|UniProtKB=T1FTF4 T1FTF4 20212101 PTHR15741:SF37 BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR LD38259P sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HELRO|EnsemblGenome=HelroG187002|UniProtKB=T1FP53 T1FP53 20210600 PTHR24031:SF25 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX46-RELATED cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;cellular process#GO:0009987;RNA splicing#GO:0008380;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions#GO:0000375;metabolic process#GO:0008152;mRNA splicing, via spliceosome#GO:0000398;organic substance metabolic process#GO:0071704 membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG191106|UniProtKB=T1FSL3 T1FSL3 20211810 PTHR22906:SF53 PROPERDIN HEMICENTIN-1 HELRO|EnsemblGenome=HelroG184992|UniProtKB=T1FM87 T1FM87 20209936 PTHR11523:SF28 SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT NA_K-ATPASE BETA SUBUNIT ISOFORM 4-RELATED molecular function activator activity#GO:0140677;ATPase activator activity#GO:0001671;molecular function regulator activity#GO:0098772 inorganic ion homeostasis#GO:0098771;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;inorganic cation transmembrane transport#GO:0098662;transport#GO:0006810;sodium ion homeostasis#GO:0055078;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;inorganic ion transmembrane transport#GO:0098660;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;localization#GO:0051179;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;intracellular monoatomic cation homeostasis#GO:0030003;potassium ion transmembrane transport#GO:0071805;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;import into cell#GO:0098657;monoatomic cation transmembrane transport#GO:0098655;export from cell#GO:0140352;sodium ion transmembrane transport#GO:0035725;potassium ion import across plasma membrane#GO:1990573;potassium ion transport#GO:0006813 membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG188199|UniProtKB=T1FPR8 T1FPR8 20210815 PTHR43807:SF20 FI04487P FI04487P transaminase activity#GO:0008483;transferase activity#GO:0016740;catalytic activity#GO:0003824 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 transaminase#PC00216;transferase#PC00220;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG188628|UniProtKB=T1FQ70 T1FQ70 20210967 PTHR11157:SF69 FATTY ACID ACYL TRANSFERASE-RELATED ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 7 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824 organic acid biosynthetic process#GO:0016053;oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;monocarboxylic acid biosynthetic process#GO:0072330;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;biosynthetic process#GO:0009058;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;organic acid metabolic process#GO:0006082;membrane lipid biosynthetic process#GO:0046467;sphingolipid metabolic process#GO:0006665;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;fatty acid metabolic process#GO:0006631;membrane lipid metabolic process#GO:0006643;nitrogen compound metabolic process#GO:0006807;small molecule biosynthetic process#GO:0044283;cellular lipid metabolic process#GO:0044255;carboxylic acid metabolic process#GO:0019752;sphingolipid biosynthetic process#GO:0030148;fatty acid biosynthetic process#GO:0006633;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 acyltransferase#PC00042 HELRO|EnsemblGenome=HelroG98483|UniProtKB=T1G9N2 T1G9N2 20217778 PTHR11452:SF14 ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE ALPHA-GALACTOSIDASE A hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 carbohydrate derivative metabolic process#GO:1901135;glycosyl compound catabolic process#GO:1901658;carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;glycosyl compound metabolic process#GO:1901657;carbohydrate metabolic process#GO:0005975;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 galactosidase#PC00104;hydrolase#PC00121 HELRO|EnsemblGenome=HelroG63054|UniProtKB=T1FXA4 T1FXA4 20213452 PTHR24248:SF125 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR DOPAMINE D2-LIKE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HELRO|EnsemblGenome=HelroG185925|UniProtKB=T1FNG1 T1FNG1 20210358 PTHR11227:SF18 WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED WD REPEAT DOMAIN PHOSPHOINOSITIDE-INTERACTING PROTEIN 3 phosphatidylinositol-3-phosphate binding#GO:0032266;phosphatidylinositol bisphosphate binding#GO:1902936;small molecule binding#GO:0036094;binding#GO:0005488;lipid binding#GO:0008289;phosphatidylinositol binding#GO:0035091;anion binding#GO:0043168;ion binding#GO:0043167;phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981 cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;macroautophagy#GO:0016236;macromolecule localization#GO:0033036;macromolecule modification#GO:0043412;protein modification process#GO:0036211;autophagy of mitochondrion#GO:0000422;biosynthetic process#GO:0009058;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;cellular component disassembly#GO:0022411;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;mitochondrion organization#GO:0007005;protein metabolic process#GO:0019538;protein lipidation#GO:0006497;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;cellular catabolic process#GO:0044248;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular component organization#GO:0016043;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organelle disassembly#GO:1903008;lipoprotein biosynthetic process#GO:0042158;protein localization#GO:0008104;primary metabolic process#GO:0044238;localization#GO:0051179;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular macromolecule localization#GO:0070727;organelle organization#GO:0006996;autophagosome assembly#GO:0000045;lipoprotein metabolic process#GO:0042157;autophagy#GO:0006914 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;phagophore assembly site#GO:0000407;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;extrinsic component of membrane#GO:0019898 scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG178337|UniProtKB=T1FD32 T1FD32 20206731 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG169885|UniProtKB=T1F2E6 T1F2E6 20202996 PTHR16172:SF2 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6 cellular anatomical entity#GO:0110165;membrane#GO:0016020 HELRO|EnsemblGenome=HelroG194638|UniProtKB=T1FW95 T1FW95 20213091 PTHR13002:SF1 C3ORF1 PROTEIN-RELATED COMPLEX I ASSEMBLY FACTOR TIMMDC1, MITOCHONDRIAL cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG139499|UniProtKB=T1EIZ0 T1EIZ0 20196540 PTHR19297:SF185 GLYCOSYLTRANSFERASE 14 FAMILY MEMBER BETA-1,3-GALACTOSYL-O-GLYCOSYL-GLYCOPROTEIN BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE 3 acetylglucosaminyltransferase activity#GO:0008375;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HELRO|EnsemblGenome=HelroG132162|UniProtKB=T1EHX3 T1EHX3 20196173 PTHR10887:SF419 DNA2/NAM7 HELICASE FAMILY RNA HELICASE MOV10L1 negative regulation of gene expression#GO:0010629;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular metabolic process#GO:0031324;negative regulation of biological process#GO:0048519;negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulatory ncRNA-mediated post-transcriptional gene silencing#GO:0035194;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of cellular process#GO:0048523;regulation of metabolic process#GO:0019222;negative regulation of cellular biosynthetic process#GO:0031327;regulation of cellular metabolic process#GO:0031323 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;P granule#GO:0043186;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HELRO|EnsemblGenome=HelroG104986|UniProtKB=T1EDP6 T1EDP6 20194698 PTHR11740:SF0 CASEIN KINASE II SUBUNIT BETA CASEIN KINASE II SUBUNIT BETA protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622 kinase modulator#PC00140 Cadherin signaling pathway#P00012>Casein kinase II#P00462;Wnt signaling pathway#P00057>Casein Kinase 2#P01459;Parkinson disease#P00049>Casein kinase II#P01236 HELRO|EnsemblGenome=HelroG115050|UniProtKB=T1EG60 T1EG60 20195562 PTHR11947:SF3 PYRUVATE DEHYDROGENASE KINASE [PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;kinase activity#GO:0016301;protein kinase activity#GO:0004672 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;cellular metabolic process#GO:0044237;protein phosphorylation#GO:0006468;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phosphate-containing compound metabolic process#GO:0006796;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;nitrogen compound metabolic process#GO:0006807;biological regulation#GO:0065007;phosphorylation#GO:0016310;protein metabolic process#GO:0019538;regulation of metabolic process#GO:0019222;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG185740|UniProtKB=T1FN80 T1FN80 20210278 PTHR37164:SF1 BACTERIOHEMERYTHRIN BACTERIOHEMERYTHRIN HELRO|EnsemblGenome=HelroG183654|UniProtKB=T1FK00 T1FK00 20209149 PTHR12069:SF0 DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5 DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5 cellular aromatic compound metabolic process#GO:0006725;DNA-templated transcription#GO:0006351;tRNA metabolic process#GO:0006399;heterocycle metabolic process#GO:0046483;transcription by RNA polymerase III#GO:0006383;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;organic substance biosynthetic process#GO:1901576;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;heterocycle biosynthetic process#GO:0018130;ncRNA metabolic process#GO:0034660;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound biosynthetic process#GO:0034654;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;ncRNA transcription#GO:0098781;aromatic compound biosynthetic process#GO:0019438;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;DNA-directed RNA polymerase complex#GO:0000428;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;RNA polymerase III complex#GO:0005666;nuclear DNA-directed RNA polymerase complex#GO:0055029;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HELRO|EnsemblGenome=HelroG112342|UniProtKB=T1EFI9 T1EFI9 20195341 PTHR10241:SF29 LETHAL 2 GIANT LARVAE PROTEIN LETHAL(2) GIANT LARVAE PROTEIN nucleoside-triphosphatase regulator activity#GO:0060589;cytoskeletal protein binding#GO:0008092;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;myosin binding#GO:0017022;GTPase activator activity#GO:0005096;molecular function regulator activity#GO:0098772;binding#GO:0005488;syntaxin binding#GO:0019905;protein binding#GO:0005515;enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;SNARE binding#GO:0000149 establishment or maintenance of cell polarity#GO:0007163;cellular localization#GO:0051641;organelle localization#GO:0051640;post-Golgi vesicle-mediated transport#GO:0006892;transport#GO:0006810;establishment of spindle orientation#GO:0051294;regulation of signaling#GO:0023051;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;regulation of Notch signaling pathway#GO:0008593;Golgi to plasma membrane transport#GO:0006893;regulation of biological process#GO:0050789;establishment of cell polarity#GO:0030010;actin filament-based process#GO:0030029;establishment of localization#GO:0051234;secretion#GO:0046903;regulation of signal transduction#GO:0009966;cytoskeleton organization#GO:0007010;establishment of organelle localization#GO:0051656;spindle localization#GO:0051653;secretion by cell#GO:0032940;localization within membrane#GO:0051668;regulation of cell communication#GO:0010646;vesicle-mediated transport to the plasma membrane#GO:0098876;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;establishment of spindle localization#GO:0051293;localization#GO:0051179;regulation of response to stimulus#GO:0048583;cellular component organization or biogenesis#GO:0071840;exocytosis#GO:0006887;microtubule-based process#GO:0007017;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;cortical cytoskeleton organization#GO:0030865;biological regulation#GO:0065007;cell cycle#GO:0007049;establishment of localization in cell#GO:0051649;actin cytoskeleton organization#GO:0030036;export from cell#GO:0140352;cortical actin cytoskeleton organization#GO:0030866 intracellular non-membrane-bounded organelle#GO:0043232;cytoplasm#GO:0005737;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;cytoskeleton#GO:0005856;cortical actin cytoskeleton#GO:0030864;cellular anatomical entity#GO:0110165;cell cortex#GO:0005938;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 HELRO|EnsemblGenome=HelroG193921|UniProtKB=T1FVH2 T1FVH2 20212818 PTHR19325:SF574 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING SUSHI, VON WILLEBRAND FACTOR TYPE A, EGF AND PENTRAXIN DOMAIN-CONTAINING PROTEIN 1 complement component#PC00078 HELRO|EnsemblGenome=HelroG191748|UniProtKB=T1FT95 T1FT95 20212042 PTHR19269:SF45 TROPOMYOSIN TROPOMYOSIN-1, ISOFORMS 33_34 cytoskeletal protein#PC00085;actin binding motor protein#PC00040 HELRO|EnsemblGenome=HelroG72567|UniProtKB=T1G119 T1G119 20214767 PTHR13806:SF46 FLOTILLIN-RELATED FLOTILLIN-1-RELATED enzyme binding#GO:0019899;protein binding#GO:0005515;protease binding#GO:0002020;binding#GO:0005488 localization#GO:0051179;protein localization to plasma membrane#GO:0072659;protein localization to cell periphery#GO:1990778;localization within membrane#GO:0051668;cellular localization#GO:0051641;cellular macromolecule localization#GO:0070727;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;cellular process#GO:0009987;protein localization#GO:0008104 cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886 HELRO|EnsemblGenome=HelroG194423|UniProtKB=T1FW15 T1FW15 20213011 PTHR16487:SF0 PPP4R2-RELATED PROTEIN PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2-RELATED phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG101454|UniProtKB=T1ED46 T1ED46 20194498 PTHR48109:SF4 DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cellular aromatic compound metabolic process#GO:0006725;pyrimidine nucleotide metabolic process#GO:0006220;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;pyrimidine-containing compound metabolic process#GO:0072527;biosynthetic process#GO:0009058;nucleobase metabolic process#GO:0009112;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;phosphate-containing compound metabolic process#GO:0006796;pyrimidine nucleobase metabolic process#GO:0006206;organic cyclic compound metabolic process#GO:1901360;ribose phosphate metabolic process#GO:0019693;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;nucleoside phosphate metabolic process#GO:0006753;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152;heterocycle metabolic process#GO:0046483;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;organic substance biosynthetic process#GO:1901576;organic cyclic compound biosynthetic process#GO:1901362;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide metabolic process#GO:0009259;heterocycle biosynthetic process#GO:0018130;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound biosynthetic process#GO:0034654;aromatic compound biosynthetic process#GO:0019438;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;small molecule metabolic process#GO:0044281 dehydrogenase#PC00092;oxidoreductase#PC00176 De novo pyrimidine ribonucleotides biosythesis#P02740>Dihydrooratate oxidase#P02927 HELRO|EnsemblGenome=HelroG158644|UniProtKB=T1EN27 T1EN27 20197977 PTHR36191:SF11 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED BRCT DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG178923|UniProtKB=T1FDW6 T1FDW6 20207015 PTHR12307:SF36 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT GLYCOGEN-BINDING SUBUNIT 76A phosphatase binding#GO:0019902;enzyme binding#GO:0019899;protein binding#GO:0005515;protein phosphatase binding#GO:0019903;binding#GO:0005488 protein serine/threonine phosphatase complex#GO:0008287;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical entity#GO:0110165;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 phosphatase modulator#PC00184 HELRO|EnsemblGenome=HelroG178829|UniProtKB=T1FDT1 T1FDT1 20206980 PTHR10334:SF590 CYSTEINE-RICH SECRETORY PROTEIN-RELATED SCP DOMAIN-CONTAINING PROTEIN extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HELRO|EnsemblGenome=HelroG93271|UniProtKB=T1G8U7 T1G8U7 20217494 PTHR11482:SF6 ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE ORNITHINE DECARBOXYLASE 1-RELATED lyase activity#GO:0016829;carboxy-lyase activity#GO:0016831;carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824 amine metabolic process#GO:0009308;oxoacid metabolic process#GO:0043436;biogenic amine metabolic process#GO:0006576;organonitrogen compound biosynthetic process#GO:1901566;organonitrogen compound metabolic process#GO:1901564;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;polyamine metabolic process#GO:0006595;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;cellular nitrogen compound biosynthetic process#GO:0044271;alpha-amino acid metabolic process#GO:1901605;polyamine biosynthetic process#GO:0006596;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 decarboxylase#PC00089 Ornithine degradation#P02758>Ornithine decarboxylase#P03053 HELRO|EnsemblGenome=HelroG185541|UniProtKB=T1FMY4 T1FMY4 20210183 PTHR15241:SF304 TRANSFORMER-2-RELATED RRM DOMAIN-CONTAINING PROTEIN RNA splicing factor#PC00148;RNA processing factor#PC00147 HELRO|EnsemblGenome=HelroG159709|UniProtKB=T1EPC1 T1EPC1 20198421 PTHR11941:SF27 ENOYL-COA HYDRATASE-RELATED ETHYLMALONYL-COA DECARBOXYLASE lipid metabolic process#GO:0006629;oxoacid metabolic process#GO:0043436;cellular metabolic process#GO:0044237;lipid oxidation#GO:0034440;lipid modification#GO:0030258;lipid catabolic process#GO:0016042;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;fatty acid catabolic process#GO:0009062;primary metabolic process#GO:0044238;fatty acid metabolic process#GO:0006631;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;fatty acid beta-oxidation#GO:0006635;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;cellular lipid metabolic process#GO:0044255;carboxylic acid catabolic process#GO:0046395;cellular lipid catabolic process#GO:0044242;carboxylic acid metabolic process#GO:0019752;cellular catabolic process#GO:0044248;monocarboxylic acid catabolic process#GO:0072329;small molecule metabolic process#GO:0044281;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 cytoplasm#GO:0005737;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;intracellular anatomical structure#GO:0005622 hydratase#PC00120 Succinate to proprionate conversion#P02777>Methylmalonyl-CoA decarboxylase#P03163 HELRO|EnsemblGenome=HelroG101525|UniProtKB=T1ED52 T1ED52 20194504 PTHR16189:SF0 TRANSMEMBRANE PROTEIN 104-RELATED TRANSMEMBRANE PROTEIN 104 HELRO|EnsemblGenome=HelroG137215|UniProtKB=T1EII2 T1EII2 20196382 PTHR19143:SF462 FIBRINOGEN/TENASCIN/ANGIOPOEITIN APPLE DOMAIN-CONTAINING PROTEIN external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG135395|UniProtKB=T1EI86 T1EI86 20196286 PTHR12932:SF9 P25 ALPHA-RELATED TUBULIN POLYMERIZATION-PROMOTING PROTEIN HOMOLOG cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;tubulin binding#GO:0015631;binding#GO:0005488 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;microtubule cytoskeleton organization#GO:0000226;protein-containing complex assembly#GO:0065003;regulation of cellular component organization#GO:0051128;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule polymerization or depolymerization#GO:0031109;positive regulation of protein polymerization#GO:0032273;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of protein-containing complex assembly#GO:0043254;microtubule polymerization#GO:0046785;microtubule-based process#GO:0007017;organelle organization#GO:0006996;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;protein-containing complex organization#GO:0043933;supramolecular fiber organization#GO:0097435;microtubule bundle formation#GO:0001578;biological regulation#GO:0065007;protein polymerization#GO:0051258;positive regulation of cellular component organization#GO:0051130;cytoskeleton organization#GO:0007010;positive regulation of cellular component biogenesis#GO:0044089;regulation of protein polymerization#GO:0032271;positive regulation of biological process#GO:0048518 intracellular non-membrane-bounded organelle#GO:0043232;supramolecular complex#GO:0099080;non-membrane-bounded organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cellular anatomical entity#GO:0110165;cytoskeleton#GO:0005856;organelle#GO:0043226;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HELRO|EnsemblGenome=HelroG79299|UniProtKB=T1G3M3 T1G3M3 20215671 PTHR10367:SF17 MRNA-CAPPING ENZYME MRNA-CAPPING ENZYME catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;RNA processing#GO:0006396;gene expression#GO:0010467;cellular metabolic process#GO:0044237;cellular biosynthetic process#GO:0044249;cellular nitrogen compound metabolic process#GO:0034641;biosynthetic process#GO:0009058;organic substance biosynthetic process#GO:1901576;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;mRNA processing#GO:0006397;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 RNA processing factor#PC00147;RNA metabolism protein#PC00031;mRNA capping factor#PC00145 HELRO|EnsemblGenome=HelroG68680|UniProtKB=T1FZI2 T1FZI2 20214230 PTHR45622:SF56 UBIQUITIN-PROTEIN LIGASE E3A-RELATED E3 UBIQUITIN-PROTEIN LIGASE HECTD2-RELATED transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG65497|UniProtKB=T1FY87 T1FY87 20213785 PTHR46961:SF17 DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN AAA+ ATPASE DOMAIN-CONTAINING PROTEIN microtubule or microtubule-binding cytoskeletal protein#PC00157 HELRO|EnsemblGenome=HelroG85035|UniProtKB=T1G5R6 T1G5R6 20216413 PTHR11533:SF299 PROTEASE M1 ZINC METALLOPROTEASE AMINOPEPTIDASE metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;small molecule binding#GO:0036094;zinc ion binding#GO:0008270;binding#GO:0005488;catalytic activity#GO:0003824;transition metal ion binding#GO:0046914;amide binding#GO:0033218;metal ion binding#GO:0046872;peptidase activity#GO:0008233;metalloaminopeptidase activity#GO:0070006;cation binding#GO:0043169;peptide binding#GO:0042277;hydrolase activity#GO:0016787;aminopeptidase activity#GO:0004177;exopeptidase activity#GO:0008238;ion binding#GO:0043167;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;peptide catabolic process#GO:0043171;cellular process#GO:0009987;primary metabolic process#GO:0044238;nitrogen compound metabolic process#GO:0006807;proteolysis#GO:0006508;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;protein metabolic process#GO:0019538;amide metabolic process#GO:0043603;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;cellular anatomical entity#GO:0110165;extracellular space#GO:0005615;membrane#GO:0016020;extracellular region#GO:0005576;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG74654|UniProtKB=T1G1T7 T1G1T7 20215035 PTHR20955:SF1 PROTEIN JAGUNAL HOMOLOG 1 PROTEIN JAGUNAL HOMOLOG 1 localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;endoplasmic reticulum organization#GO:0007029;establishment of localization#GO:0051234;organelle organization#GO:0006996;transport#GO:0006810;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;cellular component organization#GO:0016043;cellular process#GO:0009987 cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622 HELRO|EnsemblGenome=HelroG75568|UniProtKB=T1G266 T1G266 20215164 PTHR10972:SF209 OXYSTEROL-BINDING PROTEIN-RELATED OXYSTEROL-BINDING PROTEIN binding#GO:0005488;organic cyclic compound binding#GO:0097159;sterol transporter activity#GO:0015248;steroid binding#GO:0005496;sterol binding#GO:0032934;lipid binding#GO:0008289;lipid transporter activity#GO:0005319;transporter activity#GO:0005215 cytoplasm#GO:0005737;perinuclear region of cytoplasm#GO:0048471;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical entity#GO:0110165;cell periphery#GO:0071944;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 transfer/carrier protein#PC00219 HELRO|EnsemblGenome=HelroG161674|UniProtKB=T1ERS1 T1ERS1 20199271 PTHR24269:SF16 KREMEN PROTEIN PROTEIN SLG1 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HELRO|EnsemblGenome=HelroG87388|UniProtKB=T1G6P5 T1G6P5 20216742 PTHR11743:SF70 VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL GH26960P-RELATED voltage-gated monoatomic ion channel activity#GO:0005244;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216 envelope#GO:0031975;bounding membrane of organelle#GO:0098588;mitochondrial membrane#GO:0031966;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867 ion channel#PC00133;transporter#PC00227;voltage-gated ion channel#PC00241 HELRO|EnsemblGenome=HelroG100933|UniProtKB=T1ED21 T1ED21 20194473 PTHR11629:SF63 VACUOLAR PROTON ATPASES V-TYPE PROTON ATPASE SUBUNIT A enzyme binding#GO:0019899;protein binding#GO:0005515;binding#GO:0005488 regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;regulation of biological quality#GO:0065008;intracellular monoatomic cation homeostasis#GO:0030003;biological regulation#GO:0065007;intracellular pH reduction#GO:0051452;homeostatic process#GO:0042592;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic ion homeostasis#GO:0006873;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;vacuolar acidification#GO:0007035;regulation of cellular pH#GO:0030641;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801 bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;vacuolar membrane#GO:0005774;ATPase complex#GO:1904949;vacuole#GO:0005773;organelle membrane#GO:0031090;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;proton-transporting two-sector ATPase complex#GO:0016469;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HELRO|EnsemblGenome=HelroG169281|UniProtKB=T1F1Q0 T1F1Q0 20202750 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG172937|UniProtKB=T1F660 T1F660 20204309 PTHR33776:SF3 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN PHD-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG184907|UniProtKB=T1FM58 T1FM58 20209907 PTHR24291:SF175 CYTOCHROME P450 FAMILY 4 CYTOCHROME P450 oxygenase#PC00177;oxidoreductase#PC00176 HELRO|EnsemblGenome=HelroG114909|UniProtKB=T1EG53 T1EG53 20195555 PTHR43206:SF1 AMINOTRANSFERASE 4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL transferase activity#GO:0016740;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;organic cyclic compound binding#GO:0097159;transaminase activity#GO:0008483;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;ion binding#GO:0043167 oxoacid metabolic process#GO:0043436;organonitrogen compound metabolic process#GO:1901564;organonitrogen compound catabolic process#GO:1901565;cellular metabolic process#GO:0044237;cellular process#GO:0009987;organic acid metabolic process#GO:0006082;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;amino acid catabolic process#GO:0009063;organic acid catabolic process#GO:0016054;small molecule catabolic process#GO:0044282;nitrogen compound metabolic process#GO:0006807;catabolic process#GO:0009056;organic substance catabolic process#GO:1901575;carboxylic acid catabolic process#GO:0046395;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;cellular catabolic process#GO:0044248;metabolic process#GO:0008152;organic substance metabolic process#GO:0071704 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;mitochondrion#GO:0005739;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 transaminase#PC00216 Aminobutyrate degradation#P02726>4-aminobutyrate aminotransferase#P02825;Pyrimidine Metabolism#P02771>Aminotransferase#P03129;Gamma-aminobutyric acid synthesis#P04384>GABA aminotransferase#P04480 HELRO|EnsemblGenome=HelroG171529|UniProtKB=T1F4D8 T1F4D8 20203687 PTHR31196:SF2 RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED HELRO|EnsemblGenome=HelroG101195|UniProtKB=T1ED35 T1ED35 20194487 PTHR11915:SF447 SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN SPECTRIN BETA CHAIN cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;actin binding#GO:0003779;binding#GO:0005488;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;organelle organization#GO:0006996 cortical cytoskeleton#GO:0030863;cell junction#GO:0030054;cellular anatomical entity#GO:0110165;cell cortex#GO:0005938;cell periphery#GO:0071944;cortical actin cytoskeleton#GO:0030864;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoskeleton#GO:0005856;cell projection#GO:0042995;plasma membrane#GO:0005886 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HELRO|EnsemblGenome=HelroG64541|UniProtKB=T1FXW2 T1FXW2 20213660 PTHR23189:SF45 RNA RECOGNITION MOTIF-CONTAINING RNA-BINDING PROTEIN SPENITO RNA metabolism protein#PC00031 HELRO|EnsemblGenome=HelroG191970|UniProtKB=T1FTG8 T1FTG8 20212115 PTHR23280:SF21 4.1 G PROTEIN PROTEIN 4.1 HOMOLOG cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG180127|UniProtKB=T1FFH8 T1FFH8 20207577 PTHR37162:SF1 HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED BED-TYPE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG164456|UniProtKB=T1EVF8 T1EVF8 20200558 PTHR46077:SF5 E3 UBIQUITIN-PROTEIN LIGASE TOPORS RING-TYPE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;nitrogen compound metabolic process#GO:0006807;protein monoubiquitination#GO:0006513;organonitrogen compound metabolic process#GO:1901564;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HELRO|EnsemblGenome=HelroG170682|UniProtKB=T1F3B3 T1F3B3 20203312 PTHR46601:SF1 ULP_PROTEASE DOMAIN-CONTAINING PROTEIN ADF-H DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG161638|UniProtKB=T1ERQ8 T1ERQ8 20199258 PTHR10649:SF12 ARYL HYDROCARBON RECEPTOR SPINELESS, ISOFORM C sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;organic cyclic compound binding#GO:0097159;DNA binding#GO:0003677;molecular transducer activity#GO:0060089;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of nitrogen compound metabolic process#GO:0051171;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular biosynthetic process#GO:0031326;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cellular metabolic process#GO:0031323 receptor complex#GO:0043235;protein-containing complex#GO:0032991;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical entity#GO:0110165;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 basic helix-loop-helix transcription factor#PC00055 HELRO|EnsemblGenome=HelroG71611|UniProtKB=T1G0P0 T1G0P0 20214638 PTHR12159:SF9 G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity, acting on DNA#GO:0140097;DNA N-glycosylase activity#GO:0019104;catalytic activity#GO:0003824 DNA repair#GO:0006281;cellular aromatic compound metabolic process#GO:0006725;heterocycle metabolic process#GO:0046483;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular metabolic process#GO:0044237;base-excision repair#GO:0006284;cellular nitrogen compound metabolic process#GO:0034641;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;DNA damage response#GO:0006974;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;organic cyclic compound metabolic process#GO:1901360;nitrogen compound metabolic process#GO:0006807;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259;organic substance metabolic process#GO:0071704;metabolic process#GO:0008152 DNA glycosylase#PC00010 HELRO|EnsemblGenome=HelroG166878|UniProtKB=T1EYP4 T1EYP4 20201694 PTHR33776:SF4 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN HELRO|EnsemblGenome=HelroG65797|UniProtKB=T1FYC7 T1FYC7 20213825 PTHR10024:SF227 SYNAPTOTAGMIN SYNAPTOTAGMIN 1 cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;phosphatidylserine binding#GO:0001786;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;protein binding#GO:0005515;clathrin binding#GO:0030276;lipid binding#GO:0008289;ion binding#GO:0043167;phospholipid binding#GO:0005543;SNARE binding#GO:0000149 cellular localization#GO:0051641;synaptic vesicle cycle#GO:0099504;synaptic vesicle endocytosis#GO:0048488;transport#GO:0006810;regulation of biological process#GO:0050789;regulated exocytosis#GO:0045055;synaptic vesicle recycling#GO:0036465;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;anterograde trans-synaptic signaling#GO:0098916;secretion#GO:0046903;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;signal release#GO:0023061;calcium-ion regulated exocytosis#GO:0017156;cell-cell signaling#GO:0007267;signaling#GO:0023052;synaptic vesicle exocytosis#GO:0016079;secretion by cell#GO:0032940;neurotransmitter secretion#GO:0007269;endocytosis#GO:0006897;trans-synaptic signaling#GO:0099537;vesicle-mediated transport#GO:0016192;cell communication#GO:0007154;cellular process#GO:0009987;localization#GO:0051179;signal release from synapse#GO:0099643;exocytosis#GO:0006887;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;import into cell#GO:0098657;export from cell#GO:0140352;vesicle-mediated transport in synapse#GO:0099003 intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;vesicle#GO:0031982;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;exocytic vesicle#GO:0070382;endomembrane system#GO:0012505;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transport vesicle#GO:0030133;secretory vesicle#GO:0099503;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HELRO|EnsemblGenome=HelroG166584|UniProtKB=T1EY99 T1EY99 20201549 PTHR14559:SF11 CASPASE RECRUITMENT DOMAIN FAMILY SECRETED PROTEIN scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG89118|UniProtKB=T1G789 T1G789 20216936 PTHR22906:SF53 PROPERDIN HEMICENTIN-1 HELRO|EnsemblGenome=HelroG186439|UniProtKB=T1FNZ6 T1FNZ6 20210543 PTHR10857:SF102 COPINE C2 DOMAIN-CONTAINING PROTEIN lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;cellular process#GO:0009987;response to chemical#GO:0042221 cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 calcium-binding protein#PC00060 HELRO|EnsemblGenome=HelroG83876|UniProtKB=T1G5B2 T1G5B2 20216259 PTHR19143:SF458 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell periphery#GO:0071944;collagen-containing extracellular matrix#GO:0062023;extracellular space#GO:0005615;cellular anatomical entity#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HELRO|EnsemblGenome=HelroG71602|UniProtKB=T1G0N9 T1G0N9 20214637 PTHR14167:SF81 SH3 DOMAIN-CONTAINING ENDOPHILIN-A scaffold/adaptor protein#PC00226 HELRO|EnsemblGenome=HelroG84784|UniProtKB=T1G5N6 T1G5N6 20216383 PTHR10877:SF183 POLYCYSTIN FAMILY MEMBER AT14535P-RELATED ion channel#PC00133;transporter#PC00227 HELRO|EnsemblGenome=HelroG95214|UniProtKB=T1G951 T1G951 20217598 PTHR21538:SF23 ANILLIN/RHOTEKIN RTKN ANILLIN cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cell division#GO:0051301;actomyosin contractile ring assembly#GO:0000915;cell cycle process#GO:0022402;actomyosin structure organization#GO:0031032;cellular component organization#GO:0016043;cellular process#GO:0009987;cytokinetic process#GO:0032506;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;mitotic cytokinesis#GO:0000281;mitotic cell cycle#GO:0000278;actin filament-based process#GO:0030029;organelle organization#GO:0006996;cortical cytoskeleton organization#GO:0030865;cytoskeleton-dependent cytokinesis#GO:0061640;cell cycle#GO:0007049;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cytokinesis#GO:0000910;cortical actin cytoskeleton organization#GO:0030866;septin cytoskeleton organization#GO:0032185 actomyosin contractile ring#GO:0005826;cortical cytoskeleton#GO:0030863;cell cortex#GO:0005938;cell periphery#GO:0071944;cortical actin cytoskeleton#GO:0030864;cellular anatomical entity#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular non-membrane-bounded organelle#GO:0043232;non-membrane-bounded organelle#GO:0043228;actin cytoskeleton#GO:0015629;cell division site#GO:0032153;contractile ring#GO:0070938;cytoskeleton#GO:0005856 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HELRO|EnsemblGenome=HelroG185104|UniProtKB=T1FME5 T1FME5 20209994 PTHR10264:SF19 BAND 7 PROTEIN-RELATED AT06885P-RELATED cell periphery#GO:0071944;cellular anatomical entity#GO:0110165;membrane#GO:0016020;plasma membrane#GO:0005886 cytoskeletal protein#PC00085 HELRO|EnsemblGenome=HelroG194330|UniProtKB=T1FVY0 T1FVY0 20212976 PTHR11679:SF3 VESICLE PROTEIN SORTING-ASSOCIATED VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 45 cellular localization#GO:0051641;macromolecule localization#GO:0033036;transport#GO:0006810;nitrogen compound transport#GO:0071705;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein localization#GO:0008104;localization#GO:0051179;organic substance transport#GO:0071702;cellular macromolecule localization#GO:0070727;establishment of localization#GO:0051234;protein transport#GO:0015031;establishment of localization in cell#GO:0051649;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907 cytoplasm#GO:0005737;bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;cellular anatomical entity#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 membrane trafficking regulatory protein#PC00151